| Year |
Citation |
Score |
| 2024 |
Horvath RM, Brumme ZL, Sadowski I. Small molecule inhibitors of transcriptional cyclin-dependent kinases impose HIV-1 latency, presenting "block and lock" treatment strategies. Antimicrobial Agents and Chemotherapy. 68: e0107223. PMID 38319085 DOI: 10.1128/aac.01072-23 |
0.304 |
|
| 2023 |
Horvath RM, Brumme ZL, Sadowski I. CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells. Journal of Virology. 97: e0092323. PMID 37671866 DOI: 10.1128/jvi.00923-23 |
0.35 |
|
| 2023 |
Horvath RM, Sadowski I. Upstream Stimulatory Factors Regulate HIV-1 Latency and Are Required for Robust T Cell Activation. Viruses. 15. PMID 37515158 DOI: 10.3390/v15071470 |
0.402 |
|
| 2023 |
Horvath RM, Dahabieh M, Malcolm T, Sadowski I. TRIM24 controls induction of latent HIV-1 by stimulating transcriptional elongation. Communications Biology. 6: 86. PMID 36690785 DOI: 10.1038/s42003-023-04484-z |
0.373 |
|
| 2023 |
Horvath RM, Brumme ZL, Sadowski I. Inhibition of the TRIM24 bromodomain reactivates latent HIV-1. Scientific Reports. 13: 556. PMID 36631514 DOI: 10.1038/s41598-023-27765-3 |
0.309 |
|
| 2021 |
Horvath R, Hawe N, Lam C, Mestnikov K, Eji-Lasisi M, Rohde J, Sadowski I. TORC1 signaling modulates Cdk8-dependent GAL gene expression in Saccharomyces cerevisiae. Genetics. PMID 34849833 DOI: 10.1093/genetics/iyab168 |
0.672 |
|
| 2019 |
Hashemi P, Sadowski I. Diversity of small molecule HIV-1 latency reversing agents identified in low- and high-throughput small molecule screens. Medicinal Research Reviews. PMID 31608481 DOI: 10.1002/Med.21638 |
0.322 |
|
| 2019 |
Aristizabal MJ, Dever K, Negri GL, Shen M, Hawe N, Benschop JJ, Holstege FC, Krogran NJ, Sadowski I, Kobor MS. Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA Polymerase II-CTD phosphatase, Fcp1 and Mediator kinase subunit, Cdk8 in yeast. The Journal of Biological Chemistry. PMID 31506296 DOI: 10.1074/Jbc.Ra119.008515 |
0.464 |
|
| 2019 |
Sadowski I, Hashemi FB. Strategies to eradicate HIV from infected patients: elimination of latent provirus reservoirs. Cellular and Molecular Life Sciences : Cmls. PMID 31129856 DOI: 10.1007/S00018-019-03156-8 |
0.333 |
|
| 2017 |
Hashemi P, Barreto K, Bernhard W, Lomness A, Honson N, Pfeifer TA, Harrigan PR, Sadowski I. Compounds producing an effective combinatorial regimen for disruption of HIV-1 latency. Embo Molecular Medicine. PMID 29246970 DOI: 10.15252/Emmm.201708193 |
0.345 |
|
| 2016 |
Hashemi FB, Barreto K, Bernhard W, Hashemi P, Lomness A, Sadowski I. HIV Provirus Stably Reproduces Parental Latent and Induced Transcription Phenotypes Regardless of the Chromosomal Integration Site. Journal of Virology. 90: 5302-14. PMID 26984732 DOI: 10.1128/Jvi.02842-15 |
0.376 |
|
| 2014 |
Dahabieh MS, Ooms M, Brumme C, Taylor J, Harrigan PR, Simon V, Sadowski I. Direct non-productive HIV-1 infection in a T-cell line is driven by cellular activation state and NFκB. Retrovirology. 11: 17. PMID 24502247 DOI: 10.1186/1742-4690-11-17 |
0.36 |
|
| 2013 |
Bernhard W, Barreto K, Raithatha S, Sadowski I. An Upstream YY1 Binding Site on the HIV-1 LTR Contributes to Latent Infection Plos One. 8. PMID 24116200 DOI: 10.1371/Journal.Pone.0077052 |
0.398 |
|
| 2013 |
Sadowski I, Breitkreutz BJ, Stark C, Su TC, Dahabieh M, Raithatha S, Bernhard W, Oughtred R, Dolinski K, Barreto K, Tyers M. The PhosphoGRID Saccharomyces cerevisiae protein phosphorylation site database: Version 2.0 update Database. 2013. PMID 23674503 DOI: 10.1093/Database/Bat026 |
0.378 |
|
| 2013 |
Dahabieh MS, Ooms M, Simon V, Sadowski I. A doubly fluorescent HIV-1 reporter shows that the majority of integrated HIV-1 is latent shortly after infection. Journal of Virology. 87: 4716-27. PMID 23408629 DOI: 10.1128/Jvi.03478-12 |
0.336 |
|
| 2012 |
Raithatha S, Su TC, Lourenco P, Goto S, Sadowski I. Cdk8 regulates stability of the transcription factor Phd1 to control pseudohyphal differentiation of Saccharomyces cerevisiae. Molecular and Cellular Biology. 32: 664-74. PMID 22124158 DOI: 10.1128/Mcb.05420-11 |
0.496 |
|
| 2011 |
Bernhard W, Barreto K, Saunders A, Dahabieh MS, Johnson P, Sadowski I. The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response Febs Letters. 585: 3549-3554. PMID 22020221 DOI: 10.1016/J.Febslet.2011.10.018 |
0.35 |
|
| 2011 |
Dahabieh MS, Ooms M, Malcolm T, Simon V, Sadowski I. Identification and functional analysis of a second RBF-2 binding site within the HIV-1 promoter. Virology. 418: 57-66. PMID 21813151 DOI: 10.1016/J.Virol.2011.07.002 |
0.459 |
|
| 2010 |
Su TC, Tamarkina E, Sadowski I. Organizational constraints on Ste12 cis-elements for a pheromone response in Saccharomyces cerevisiae. The Febs Journal. 277: 3235-48. PMID 20584076 DOI: 10.1111/J.1742-4658.2010.07728.X |
0.438 |
|
| 2010 |
Stark C, Su TC, Breitkreutz A, Lourenco P, Dahabieh M, Breitkreutz BJ, Tyers M, Sadowski I. PhosphoGRID: a database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae. Database : the Journal of Biological Databases and Curation. 2010: bap026. PMID 20428315 DOI: 10.1093/Database/Bap026 |
0.435 |
|
| 2008 |
Malcolm T, Kam J, Pour PS, Sadowski I. Specific interaction of TFII-I with an upstream element on the HIV-1 LTR regulates induction of latent provirus Febs Letters. 582: 3903-3908. PMID 18976654 DOI: 10.1016/J.Febslet.2008.10.032 |
0.435 |
|
| 2008 |
Sadowski I, Lourenco P, Malcolm T. Factors controlling chromatin organization and nucleosome positioning for establishment and maintenance of HIV latency. Current Hiv Research. 6: 286-95. PMID 18691027 DOI: 10.2174/157016208785132563 |
0.435 |
|
| 2007 |
Malcolm T, Chen J, Chang C, Sadowski I. Induction of chromosomally integrated HIV-1 LTR requires RBF-2 (USF/TFII-I) and Ras/MAPK signaling. Virus Genes. 35: 215-23. PMID 17546494 DOI: 10.1007/S11262-007-0109-9 |
0.439 |
|
| 2007 |
Joshi PB, Hirst M, Malcolm T, Parent J, Mitchell D, Lund K, Sadowski I. Identification of protein interaction antagonists using the repressed transactivator two-hybrid system. Biotechniques. 42: 635-44. PMID 17515203 DOI: 10.2144/000112434 |
0.326 |
|
| 2005 |
Sadowski I, Mitchell DA. TFII-I and USF (RBF-2) regulate Ras/MAPK-responsive HIV-1 transcription in T cells. European Journal of Cancer (Oxford, England : 1990). 41: 2528-36. PMID 16223582 DOI: 10.1016/J.Ejca.2005.08.011 |
0.456 |
|
| 2005 |
Chen J, Sadowski I. Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements. Proceedings of the National Academy of Sciences of the United States of America. 102: 4813-8. PMID 15781865 DOI: 10.1073/Pnas.0407069102 |
0.383 |
|
| 2005 |
Chen J, Malcolm T, Estable MC, Roeder RG, Sadowski I. TFII-I regulates induction of chromosomally integrated human immunodeficiency virus type 1 long terminal repeat in cooperation with USF. Journal of Virology. 79: 4396-406. PMID 15767439 DOI: 10.1128/Jvi.79.7.4396-4406.2005 |
0.455 |
|
| 2004 |
Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, ... ... Sadowski I, et al. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Molecular Cell. 14: 553-7. PMID 15175151 DOI: 10.1016/J.Molcel.2004.05.011 |
0.389 |
|
| 2003 |
Malcolm T, Ettehadieh E, Sadowski I. Mitogen-responsive expression of RhoB is regulated by RNA stability. Oncogene. 22: 6142-50. PMID 13679852 DOI: 10.1038/Sj.Onc.1206638 |
0.431 |
|
| 2003 |
Wafa LA, Cheng H, Rao MA, Nelson CC, Cox M, Hirst M, Sadowski I, Rennie PS. Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system. The Biochemical Journal. 375: 373-83. PMID 12864730 DOI: 10.1042/Bj20030689 |
0.34 |
|
| 2003 |
Nelson C, Goto S, Lund K, Hung W, Sadowski I. Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12. Nature. 421: 187-90. PMID 12520306 DOI: 10.1038/Nature01243 |
0.502 |
|
| 2002 |
Leng E, Malcolm T, Tai G, Estable M, Sadowski I. Organization and expression of the Cyr61 gene in normal human fibroblasts. Journal of Biomedical Science. 9: 59-67. PMID 11810026 DOI: 10.1159/000048200 |
0.402 |
|
| 2001 |
Hirst M, Ho C, Sabourin L, Rudnicki M, Penn L, Sadowski I. A two-hybrid system for transactivator bait proteins Proceedings of the National Academy of Sciences of the United States of America. 98: 8726-8731. PMID 11447261 DOI: 10.1073/Pnas.141413598 |
0.392 |
|
| 2000 |
Olson KA, Nelson C, Tai G, Hung W, Yong C, Astell C, Sadowski I. Two regulators of Ste12p inhibit pheromone-responsive transcription by separate mechanisms. Molecular and Cellular Biology. 20: 4199-209. PMID 10825185 DOI: 10.1128/Mcb.20.12.4199-4209.2000 |
0.476 |
|
| 2000 |
Rohde JR, Trinh J, Sadowski I. Multiple signals regulate GAL transcription in yeast Molecular and Cellular Biology. 20: 3880-3886. PMID 10805731 DOI: 10.1128/Mcb.20.11.3880-3886.2000 |
0.666 |
|
| 1999 |
Estable MC, Hirst M, Bell B, O'Shaughnessy MV, Sadowski I. Purification of RBF-2, a transcription factor with specificity for the most conserved cis-element of naturally occurring HIV-1 LTRs. Journal of Biomedical Science. 6: 320-32. PMID 10494039 DOI: 10.1007/Bf02253521 |
0.421 |
|
| 1999 |
Hirst M, Kobor MS, Kuriakose N, Greenblatt J, Sadowski I. GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8. Molecular Cell. 3: 673-8. PMID 10360183 DOI: 10.1016/S1097-2765(00)80360-3 |
0.493 |
|
| 1998 |
Yokota H, Nickerson DA, Trask BJ, van den Engh G, Hirst M, Sadowski I, Aebersold R. Mapping a protein-binding site on straightened DNA by atomic force microscopy. Analytical Biochemistry. 264: 158-64. PMID 9866677 DOI: 10.1006/Abio.1998.2851 |
0.318 |
|
| 1998 |
Estable MC, Bell B, Hirst M, Sadowski I. Naturally occurring human immunodeficiency virus type 1 long terminal repeats have a frequently observed duplication that binds RBF-2 and represses transcription. Journal of Virology. 72: 6465-74. PMID 9658089 DOI: 10.1128/Jvi.72.8.6465-6474.1998 |
0.445 |
|
| 1997 |
Hung W, Olson KA, Breitkreutz A, Sadowski I. Characterization of the basal and pheromone-stimulated phosphorylation states of Ste12p European Journal of Biochemistry. 245: 241-251. PMID 9151949 DOI: 10.1111/J.1432-1033.1997.00241.X |
0.498 |
|
| 1996 |
Sadowski I, Costa C, Dhanawansa R. Phosphorylation of Ga14p at a single C-terminal residue is necessary for galactose-inducible transcription. Molecular and Cellular Biology. 16: 4879-87. PMID 8756647 DOI: 10.1128/Mcb.16.9.4879 |
0.527 |
|
| 1993 |
Murray MG, Hung W, Sadowski I, Das Mahapatra B. Inactivation of a yeast transactivator by the fused HIV-1 proteinase: a simple assay for inhibitors of the viral enzyme activity. Gene. 134: 123-8. PMID 8244023 DOI: 10.1016/0378-1119(93)90185-6 |
0.406 |
|
| 1992 |
Sadowski I, Bell B, Broad P, Hollis M. GAL4 fusion vectors for expression in yeast or mammalian cells. Gene. 118: 137-41. PMID 1511877 DOI: 10.1016/0378-1119(92)90261-M |
0.407 |
|
| 1991 |
Sadowski I, Niedbala D, Wood K, Ptashne M. GAL4 is phosphorylated as a consequence of transcriptional activation. Proceedings of the National Academy of Sciences of the United States of America. 88: 10510-4. PMID 1961715 DOI: 10.1073/Pnas.88.23.10510 |
0.497 |
|
| 1990 |
Gill G, Sadowski I, Ptashne M. Mutations that increase the activity of a transcriptional activator in yeast and mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 87: 2127-31. PMID 2179950 DOI: 10.1073/Pnas.87.6.2127 |
0.349 |
|
| 1988 |
Sadowski I, Ma J, Triezenberg S, Ptashne M. GAL4-VP16 is an unusually potent transcriptional activator. Nature. 335: 563-4. PMID 3047590 DOI: 10.1038/335563A0 |
0.444 |
|
| 1986 |
Sadowski I, Stone JC, Pawson T. A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130(gag-fps) Molecular and Cellular Biology. 6: 4396-4408. PMID 3025655 DOI: 10.1128/Mcb.6.12.4396 |
0.403 |
|
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