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Philip J. Laipis - Publications

Affiliations: 
University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Genetics, Molecular Biology, Pathology
Website:
https://biochem.med.ufl.edu/research/emeritus-faculty/philip-laipis/
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Zeile WL, McCune HC, Musson DG, O'Donnell B, O'Neill CA, Tsuruda LS, Zori RT, Laipis PJ. Maternal Phenylketonuria syndrome: Studies in mice suggest a potential approach to a continuing problem. Pediatric Research. PMID 29278642 DOI: 10.1038/Pr.2017.323  0.318
2007 Elder I, Fisher Z, Laipis PJ, Tu C, McKenna R, Silverman DN. Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III. Proteins. 68: 337-43. PMID 17427958 DOI: 10.1002/Prot.21403  0.657
2007 Embury JE, Charron CE, Martynyuk A, Zori AG, Liu B, Ali SF, Rowland NE, Laipis PJ. PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah(enu2) mice. Brain Research. 1127: 136-50. PMID 17112485 DOI: 10.1016/J.Brainres.2006.09.101  0.709
2006 Yang S, Lee YJ, Kim JM, Park S, Peris J, Laipis P, Park YS, Chung JH, Oh SP. A murine model for human sepiapterin-reductase deficiency. American Journal of Human Genetics. 78: 575-87. PMID 16532389 DOI: 10.1086/501372  0.339
2006 Zori A, Yang DD, Knapp J, Charron CE, Embury JE, Porvasnik SL, Laipis PJ. 214. Dominant-Negative Interference in the Pahenu2 Mouse: Modified Forms of PAH Molecular Therapy. 13: S82-S83. DOI: 10.1016/J.Ymthe.2006.08.239  0.742
2005 Embury JE, Reep RR, Laipis PJ. Pathologic and immunohistochemical findings in hypothalamic and mesencephalic regions in the pah(enu2) mouse model for phenylketonuria. Pediatric Research. 58: 283-7. PMID 16055931 DOI: 10.1203/01.Pdr.0000170000.78670.44  0.304
2005 Duda DM, Tu C, Fisher SZ, An H, Yoshioka C, Govindasamy L, Laipis PJ, Agbandje-McKenna M, Silverman DN, McKenna R. Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer. Biochemistry. 44: 10046-53. PMID 16042381 DOI: 10.1021/Bi050610H  0.647
2005 Embury JE, Charron CE, Laipis PJ. 423. Increased Incidence of Hepatocellular Change and Neoplastic Disease in AAV-WPRE Treated Pahenu2 Mice Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.425  0.71
2005 Charron CE, Perera OP, Porvasnik SL, Blackburn M, Lewin AS, Laipis PJ. 422. Dominant-Negative Interference in the Pahenu2 Mouse Model of PKU: Effectiveness of Vectors Expressing Either Modified Forms of Phenylalanine Hydroxylase (PAH) or Ribozymes Plus a Hardened PAH mRNA Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.424  0.731
2004 Kang SH, Levings PP, Andersen F, Laipis PJ, Berns KI, Zori RT, Bungert J. Locus control region elements HS2 and HS3 in combination with chromatin boundaries confer high-level expression of a human beta-globin transgene in a centromeric region. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 9: 1043-53. PMID 15507116 DOI: 10.1111/J.1365-2443.2004.00788.X  0.315
2004 Elder I, Han S, Tu C, Steele H, Laipis PJ, Viola RE, Silverman DN. Activation of carbonic anhydrase II by active-site incorporation of histidine analogs. Archives of Biochemistry and Biophysics. 421: 283-9. PMID 14984209 DOI: 10.1016/J.Abb.2003.11.006  0.681
2004 Embury JE, Charron CE, Laipis PJ. 879. Morphologic and Immunohistochemical Evaluation of Dopaminergic Regions of Pahenu2 Mouse Brains Following Adminstration of rAAV-mPAH-WPRE Vector Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.785  0.691
2004 Laipis PJ, Charron CE, Embury JE, Perera OP, Porvasnik SL, Fields CR, Zori RT. 878. Correction of maternal phenylketonuria syndrome in the Pahenu2 Missense Mutant mouse by r-AAV mediated gene therapy Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.784  0.725
2004 Charron CE, Lewin AS, Laipis PJ. 877. Evidence for dominant-negative interference in the Pahenu2 mouse model of PKU Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.783  0.734
2004 Embury JE, Charron CE, Laipis PJ. 874. Hepatocellular Morphology in the Pahenu2 Mouse Model of PKU Is Altered Following Portal Vein Administration of rAAV-mPAH-WPRE Vectors Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.781  0.725
2003 Knudsen B, Miyamoto MM, Laipis PJ, Silverman DN. Using evolutionary rates to investigate protein functional divergence and conservation. A case study of the carbonic anhydrases. Genetics. 164: 1261-9. PMID 12930737  0.528
2002 An H, Tu C, Ren K, Laipis PJ, Silverman DN. Proton transfer within the active-site cavity of carbonic anhydrase III. Biochimica Et Biophysica Acta. 1599: 21-7. PMID 12484342 DOI: 10.1016/S0167-4838(02)00374-6  0.667
2002 Tu C, Qian M, An H, Wadhwa NR, Duda D, Yoshioka C, Pathak Y, McKenna R, Laipis PJ, Silverman DN. Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase. The Journal of Biological Chemistry. 277: 38870-6. PMID 12171926 DOI: 10.1074/Jbc.M205791200  0.663
2002 An H, Tu C, Duda D, Montanez-Clemente I, Math K, Laipis PJ, McKenna R, Silverman DN. Chemical rescue in catalysis by human carbonic anhydrases II and III. Biochemistry. 41: 3235-42. PMID 11863462 DOI: 10.1021/Bi0120695  0.633
2001 Wingo T, Tu C, Laipis PJ, Silverman DN. The catalytic properties of human carbonic anhydrase IX. Biochemical and Biophysical Research Communications. 288: 666-9. PMID 11676494 DOI: 10.1006/Bbrc.2001.5824  0.587
2001 Song S, Embury J, Laipis PJ, Berns KI, Crawford JM, Flotte TR. Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors. Gene Therapy. 8: 1299-306. PMID 11571566 DOI: 10.1038/Sj.Gt.3301422  0.344
2001 Duda D, Tu C, Qian M, Laipis P, Agbandje-McKenna M, Silverman DN, McKenna R. Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II. Biochemistry. 40: 1741-8. PMID 11327835 DOI: 10.1021/Bi002295Z  0.635
1999 Trachtenberg MC, Tu CK, Landers RA, Willson RC, McGregor ML, Laipis PJ, Kennedy JF, Paterson M, Silverman DN, Thomas D, Smith RL, Rudolph FB. Carbon dioxide transport by proteic and facilitated transport membranes. Life Support & Biosphere Science : International Journal of Earth Space. 6: 293-302. PMID 11543269  0.52
1999 Qian M, Earnhardt JN, Wadhwa NR, Tu C, Laipis PJ, Silverman DN. Proton transfer to residues of basic pK(a) during catalysis by carbonic anhydrase. Biochimica Et Biophysica Acta. 1434: 1-5. PMID 10556554 DOI: 10.1016/S0167-4838(99)00170-3  0.647
1999 Earnhardt JN, Wright SK, Qian M, Tu C, Laipis PJ, Viola RE, Silverman DN. Introduction of histidine analogs leads to enhanced proton transfer in carbonic anhydrase V. Archives of Biochemistry and Biophysics. 361: 264-70. PMID 9882455 DOI: 10.1006/Abbi.1998.0984  0.646
1998 Earnhardt JN, Qian M, Tu C, Lakkis MM, Bergenhem NCH, Laipis PJ, Tashian RE, Silverman DN. The catalytic properties of murine carbonic anhydrase VII Biochemistry. 37: 10837-10845. PMID 9692974 DOI: 10.1021/Bi980046T  0.622
1998 Tu C, Qian M, Earnhardt JN, Laipis PJ, Silverman DN. Properties of intramolecular proton transfer in carbonic anhydrase III. Biophysical Journal. 74: 3182-9. PMID 9635771 DOI: 10.1016/S0006-3495(98)78024-5  0.629
1998 Earnhardt JN, Qian M, Tu C, Laipis PJ, Silverman DN. Intramolecular proton transfer from multiple sites in catalysis by murine carbonic anhydrase V. Biochemistry. 37: 7649-55. PMID 9585580 DOI: 10.1021/bi9729209  0.623
1998 Stams T, Chen Y, Boriack-Sjodin PA, Hurt JD, Liao J, May JA, Dean T, Laipis P, Silverman DN, Christianson DW. Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination. Protein Science : a Publication of the Protein Society. 7: 556-63. PMID 9541386 DOI: 10.1002/Pro.5560070303  0.595
1998 Hurt JD, Tu C, Laipis PJ. Isolation and expression of murine carbonic anhydrase IV Protein Expression and Purification. 12: 7-16. PMID 9473451 DOI: 10.1006/Prep.1997.0801  0.357
1997 Qian M, Tu C, Earnhardt JN, Laipis PJ, Silverman DN. Glutamate and aspartate as proton shuttles in mutants of carbonic anhydrase. Biochemistry. 36: 15758-64. PMID 9398305 DOI: 10.1021/bi972081q  0.601
1997 Hurt JD, Tu C, Laipis PJ, Silverman DN. Catalytic properties of murine carbonic anhydrase IV Journal of Biological Chemistry. 272: 13512-13518. PMID 9153196 DOI: 10.1074/Jbc.272.21.13512  0.652
1996 Laipis PJ. Construction of heteroplasmic mice containing two mitochondrial DNA genotypes by micromanipulation of single-cell embryos. Methods in Enzymology. 264: 345-57. PMID 8965708 DOI: 10.1016/S0076-6879(96)64033-6  0.309
1996 Heck RW, Boriack-Sjodin PA, Qian M, Tu C, Christianson DW, Laipis PJ, Silverman DN. Structure-based design of an intramolecular proton transfer site in murine carbonic anhydrase V. Biochemistry. 35: 11605-11. PMID 8794740 DOI: 10.1021/bi9608018  0.619
1995 Ren X, Tu C, Laipis PJ, Silverman DN. Proton transfer by histidine 67 in site-directed mutants of human carbonic anhydrase III. Biochemistry. 34: 8492-8. PMID 7599138 DOI: 10.1021/Bi00026A033  0.653
1995 Tanhauser SM, Laipis PJ. Multiple deletions are detectable in mitochondrial DNA of aging mice. The Journal of Biological Chemistry. 270: 24769-75. PMID 7559594 DOI: 10.1074/Jbc.270.42.24769  0.314
1995 Boriack-Sjodin PA, Heck RW, Laipis PJ, Silverman DN, Christianson DW. Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor design. Proceedings of the National Academy of Sciences of the United States of America. 92: 10949-53. PMID 7479916 DOI: 10.1073/Pnas.92.24.10949  0.614
1994 Tu C, Chen X, Ren X, LoGrasso PV, Jewell DA, Laipis PJ, Silverman DN. Interactions of active-site residues and catalytic activity of human carbonic anhydrase III Journal of Biological Chemistry. 269: 23002-23006. PMID 8083199  0.74
1994 Heck RW, Tanhauser SM, Manda R, Tu C, Laipis PJ, Silverman DN. Catalytic properties of mouse carbonic anhydrase V. The Journal of Biological Chemistry. 269: 24742-6. PMID 7929150  0.55
1993 LoGrasso PV, Tu C, Chen X, Taoka S, Laipis PJ, Silverman DN. Influence of amino acid replacement at position 198 on catalytic properties of zinc-bound water in human carbonic anhydrase III. Biochemistry. 32: 5786-91. PMID 8504098 DOI: 10.1021/Bi00073A010  0.651
1993 Silverman DN, Tu C, Chen X, Tanhauser SM, Kresge AJ, Laipis PJ. Rate-equilibria relationships in intramolecular proton transfer in human carbonic anhydrase III. Biochemistry. 32: 10757-62. PMID 8399223 DOI: 10.1021/Bi00091A029  0.627
1993 Chen X, Tu C, LoGrasso PV, Laipis PJ, Silverman DN. Interaction and influence of phenylalanine-198 and threonine-199 on catalysis by human carbonic anhydrase III. Biochemistry. 32: 7861-5. PMID 8347590 DOI: 10.1021/Bi00082A004  0.656
1992 Tanhauser SM, Jewell DA, Tu CK, Silverman DN, Laipis PJ. A T7 expression vector optimized for site-directed mutagenesis using oligodeoxyribonucleotide cassettes Gene. 117: 113-117. PMID 1644301 DOI: 10.1016/0378-1119(92)90498-E  0.731
1991 LoGrasso PV, Tu CK, Jewell DA, Wynns GC, Laipis PJ, Silverman DN. Catalytic enhancement of human carbonic anhydrase III by replacement of phenylalanine-198 with leucine. Biochemistry. 30: 8463-70. PMID 1909176 DOI: 10.1021/Bi00098A025  0.77
1991 Jewell DA, Tu C, Paranawithana SR, Tanhauser SM, LoGrasso PV, Laipis PJ, Silverman DN. Enhancement of the catalytic properties of human carbonic anhydrase III by site-directed mutagenesis Biochemistry. 30: 1484-1490. PMID 1899618 DOI: 10.1021/Bi00220A006  0.771
1990 Tu C, Paranawithana SR, Jewell DA, Tanhauser SM, LoGrasso PV, Wynns GC, Laipis PJ, Silverman DN. Buffer enhancement of proton transfer in catalysis by human carbonic anhydrase III Biochemistry. 29: 6400-6405. PMID 2169869 DOI: 10.1021/Bi00479A009  0.768
1990 Paranawithana SR, Tu CK, Laipis PJ, Silverman DN. Enhancement of the catalytic activity of carbonic anhydrase III by phosphates. The Journal of Biological Chemistry. 265: 22270-4. PMID 2125046  0.626
1986 Tanhauser SM, Hauswirth WW, Laipis PJ. Conserved restriction sites within the ribosomal RNA genes of vertebrates. Biochimica Et Biophysica Acta. 866: 19-25. PMID 3004584 DOI: 10.1016/0167-4781(86)90095-3  0.31
1975 Sen A, Laipis PJ, Levine AJ. DNA replication in SV40-infected cells. XI. The properties of SV40 DNA and nucleoprotein complex synthesized in the presence of cycloheximide. Intervirology. 5: 122-36. PMID 172469 DOI: 10.1159/000149890  0.351
1975 Laipis PJ, Sen A, Levine AJ, Mulder C. DNA replication in SV40 infected cells X. The structure of the 16 S gap circle intermediate in SV40 DNA synthesis. Virology. 68: 115-23. PMID 171842 DOI: 10.1016/0042-6822(75)90153-1  0.33
1973 Laipis PJ, Levine AJ. DNA replication in SV40-infected cells. IX. The inhibition of a gap-filling step during discontinuous synthesis of SV40 DNA. Virology. 56: 580-94. PMID 4357056 DOI: 10.1016/0042-6822(73)90059-7  0.328
1972 Laipis PJ, Ganesan AT. In vitro repair of x-irradiated DNA extracted from Bacillus subtilis deficient in polymerase I. Proceedings of the National Academy of Sciences of the United States of America. 69: 3211-4. PMID 4628873 DOI: 10.1073/Pnas.69.11.3211  0.655
1972 Laipis PJ, Ganesan AT. A deoxyribonucleic acid polymerase I-deficient mutant of Bacillus subtilis. The Journal of Biological Chemistry. 247: 5867-71. PMID 4626881  0.645
1969 Laipis PJ, Olivera BM, Ganesan AT. Enzymatic cleabage and repair of transforming DNA. Proceedings of the National Academy of Sciences of the United States of America. 62: 289-96. PMID 4976949 DOI: 10.1073/pnas.62.1.289  0.643
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