Paul K. Brindle, Ph.D - Publications

Affiliations: 
Biochemistry St Jude Children's Research Hospital, New York, NY, United States 

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Zheng F, Kasper LH, Bedford DC, Lerach S, Teubner BJ, Brindle PK. Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice. Plos One. 11: e0146366. PMID 26730956 DOI: 10.1371/journal.pone.0146366  0.6
2014 Paz JC, Park S, Phillips N, Matsumura S, Tsai WW, Kasper L, Brindle PK, Zhang G, Zhou MM, Wright PE, Montminy M. Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation. Proceedings of the National Academy of Sciences of the United States of America. 111: 17116-21. PMID 25404345 DOI: 10.1073/pnas.1420389111  0.6
2014 Kasper LH, Qu C, Obenauer JC, McGoldrick DJ, Brindle PK. Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression. Nucleic Acids Research. 42: 11363-82. PMID 25249627 DOI: 10.1093/nar/gku827  0.6
2014 Liu Y, Wang L, Han R, Beier UH, Akimova T, Bhatti T, Xiao H, Cole PA, Brindle PK, Hancock WW. Two histone/protein acetyltransferases, CBP and p300, are indispensable for Foxp3+ T-regulatory cell development and function. Molecular and Cellular Biology. 34: 3993-4007. PMID 25154413 DOI: 10.1128/MCB.00919-14  0.6
2014 Kasper LH, Fukuyama T, Brindle PK. T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs. Plos One. 9: e102076. PMID 25054639 DOI: 10.1371/journal.pone.0102076  0.6
2014 Boussouar F, Goudarzi A, Buchou T, Shiota H, Barral S, Debernardi A, Guardiola P, Brindle P, Martinez G, Arnoult C, Khochbin S, Rousseaux S. A specific CBP/p300-dependent gene expression programme drives the metabolic remodelling in late stages of spermatogenesis. Andrology. 2: 351-9. PMID 24522976 DOI: 10.1111/j.2047-2927.2014.00184.x  0.6
2014 Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B. Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development (Cambridge, England). 141: 538-47. PMID 24449835 DOI: 10.1242/dev.099481  0.6
2013 Kasper LH, Fukuyama T, Lerach S, Chang Y, Xu W, Wu S, Boyd KL, Brindle PK. Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression. Plos One. 8: e82684. PMID 24340053 DOI: 10.1371/journal.pone.0082684  0.6
2013 Wolf L, Harrison W, Huang J, Xie Q, Xiao N, Sun J, Kong L, Lachke SA, Kuracha MR, Govindarajan V, Brindle PK, Ashery-Padan R, Beebe DC, Overbeek PA, Cvekl A. Histone posttranslational modifications and cell fate determination: lens induction requires the lysine acetyltransferases CBP and p300. Nucleic Acids Research. 41: 10199-214. PMID 24038357 DOI: 10.1093/nar/gkt824  0.6
2013 Liu Y, Wang L, Predina J, Han R, Beier UH, Wang LC, Kapoor V, Bhatti TR, Akimova T, Singhal S, Brindle PK, Cole PA, Albelda SM, Hancock WW. Inhibition of p300 impairs Foxp3⁺ T regulatory cell function and promotes antitumor immunity. Nature Medicine. 19: 1173-7. PMID 23955711 DOI: 10.1038/nm.3286  0.6
2012 Peifer M, Fernández-Cuesta L, Sos ML, George J, Seidel D, Kasper LH, Plenker D, Leenders F, Sun R, Zander T, Menon R, Koker M, Dahmen I, Müller C, Di Cerbo V, ... ... Brindle PK, et al. Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. Nature Genetics. 44: 1104-10. PMID 22941188 DOI: 10.1038/ng.2396  0.44
2012 Bedford DC, Brindle PK. Is histone acetylation the most important physiological function for CBP and p300? Aging. 4: 247-55. PMID 22511639  0.6
2011 Bedford DC, Kasper LH, Wang R, Chang Y, Green DR, Brindle PK. Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control. Cell Metabolism. 14: 219-30. PMID 21803292 DOI: 10.1016/j.cmet.2011.06.010  0.6
2011 Mullighan CG, Zhang J, Kasper LH, Lerach S, Payne-Turner D, Phillips LA, Heatley SL, Holmfeldt L, Collins-Underwood JR, Ma J, Buetow KH, Pui CH, Baker SD, Brindle PK, Downing JR. CREBBP mutations in relapsed acute lymphoblastic leukaemia. Nature. 471: 235-9. PMID 21390130 DOI: 10.1038/nature09727  0.6
2011 Pasqualucci L, Dominguez-Sola D, Chiarenza A, Fabbri G, Grunn A, Trifonov V, Kasper LH, Lerach S, Tang H, Ma J, Rossi D, Chadburn A, Murty VV, Mullighan CG, Gaidano G, ... ... Brindle PK, et al. Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature. 471: 189-95. PMID 21390126 DOI: 10.1038/nature09730  0.6
2011 Oliveira AM, Estévez MA, Hawk JD, Grimes S, Brindle PK, Abel T. Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments. Learning & Memory (Cold Spring Harbor, N.Y.). 18: 161-9. PMID 21345974 DOI: 10.1101/lm.1939811  0.6
2011 Kasper LH, Thomas MC, Zambetti GP, Brindle PK. Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathways. Cell Cycle (Georgetown, Tex.). 10: 212-21. PMID 21220944 DOI: 10.4161/cc.10.2.14542  0.6
2011 Jin Q, Yu LR, Wang L, Zhang Z, Kasper LH, Lee JE, Wang C, Brindle PK, Dent SY, Ge K. Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation. The Embo Journal. 30: 249-62. PMID 21131905 DOI: 10.1038/emboj.2010.318  0.6
2010 Kasper LH, Lerach S, Wang J, Wu S, Jeevan T, Brindle PK. CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation. The Embo Journal. 29: 3660-72. PMID 20859256 DOI: 10.1038/emboj.2010.235  0.6
2010 Bedford DC, Kasper LH, Fukuyama T, Brindle PK. Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases. Epigenetics : Official Journal of the Dna Methylation Society. 5: 9-15. PMID 20110770 DOI: 10.4161/epi.5.1.10449  0.6
2010 Brindle PK. Transcriptional regulation via the camp responsive activator CREB Handbook of Cell Signaling, 2/E. 3: 2077-2081. DOI: 10.1016/B978-0-12-374145-5.00253-9  0.6
2009 Fukuyama T, Kasper LH, Boussouar F, Jeevan T, van Deursen J, Brindle PK. Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Molecular and Cellular Biology. 29: 3894-904. PMID 19433445 DOI: 10.1128/MCB.01598-08  0.6
2007 Vecsey CG, Hawk JD, Lattal KM, Stein JM, Fabian SA, Attner MA, Cabrera SM, McDonough CB, Brindle PK, Abel T, Wood MA. Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6128-40. PMID 17553985 DOI: 10.1523/JNEUROSCI.0296-07.2007  0.6
2007 Xu W, Kasper LH, Lerach S, Jeevan T, Brindle PK. Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms. The Embo Journal. 26: 2890-903. PMID 17525731 DOI: 10.1038/sj.emboj.7601734  0.6
2006 Wood MA, Attner MA, Oliveira AM, Brindle PK, Abel T. A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes. Learning & Memory (Cold Spring Harbor, N.Y.). 13: 609-17. PMID 16980541 DOI: 10.1101/lm.213906  0.6
2006 Oliveira AM, Abel T, Brindle PK, Wood MA. Differential role for CBP and p300 CREB-binding domain in motor skill learning. Behavioral Neuroscience. 120: 724-9. PMID 16768624 DOI: 10.1037/0735-7044.120.3.724  0.6
2006 Kasper LH, Fukuyama T, Biesen MA, Boussouar F, Tong C, de Pauw A, Murray PJ, van Deursen JM, Brindle PK. Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Molecular and Cellular Biology. 26: 789-809. PMID 16428436 DOI: 10.1128/MCB.26.3.789-809.2006  0.6
2006 Xu W, Fukuyama T, Ney PA, Wang D, Rehg J, Boyd K, van Deursen JM, Brindle PK. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood. 107: 4407-16. PMID 16424387 DOI: 10.1182/blood-2005-08-3263  0.6
2006 Kasper LH, Brindle PK. Mammalian gene expression program resiliency: the roles of multiple coactivator mechanisms in hypoxia-responsive transcription. Cell Cycle (Georgetown, Tex.). 5: 142-6. PMID 16357535  0.6
2005 Kasper LH, Boussouar F, Boyd K, Xu W, Biesen M, Rehg J, Baudino TA, Cleveland JL, Brindle PK. Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression. The Embo Journal. 24: 3846-58. PMID 16237459 DOI: 10.1038/sj.emboj.7600846  0.6
2005 Koo SH, Flechner L, Qi L, Zhang X, Screaton RA, Jeffries S, Hedrick S, Xu W, Boussouar F, Brindle P, Takemori H, Montminy M. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature. 437: 1109-11. PMID 16148943 DOI: 10.1038/nature03967  0.6
2004 Kang-Decker N, Tong C, Boussouar F, Baker DJ, Xu W, Leontovich AA, Taylor WR, Brindle PK, van Deursen JM. Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency. Cancer Cell. 5: 177-89. PMID 14998493 DOI: 10.1016/S1535-6108(04)00022-4  0.6
2002 Kasper LH, Boussouar F, Ney PA, Jackson CW, Rehg J, van Deursen JM, Brindle PK. A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature. 419: 738-43. PMID 12384703 DOI: 10.1038/nature01062  0.6
2001 Nakajima H, Brindle PK, Handa M, Ihle JN. Functional interaction of STAT5 and nuclear receptor co-repressor SMRT: implications in negative regulation of STAT5-dependent transcription. The Embo Journal. 20: 6836-44. PMID 11726519 DOI: 10.1093/emboj/20.23.6836  0.6
1999 Parker D, Rivera M, Zor T, Henrion-Caude A, Radhakrishnan I, Kumar A, Shapiro LH, Wright PE, Montminy M, Brindle PK. Role of secondary structure in discrimination between constitutive and inducible activators. Molecular and Cellular Biology. 19: 5601-7. PMID 10409749 DOI: 10.1128/MCB.19.8.5601  0.6
1999 Kasper LH, Brindle PK, Schnabel CA, Pritchard CE, Cleary ML, van Deursen JM. CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity. Molecular and Cellular Biology. 19: 764-76. PMID 9858599  0.6
1998 Yang C, Shapiro LH, Rivera M, Kumar A, Brindle PK. A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functions. Molecular and Cellular Biology. 18: 2218-29. PMID 9528793  0.6
1996 Montminy M, Brindle P, Arias J, Ferreri K, Armstrong R. Regulation of somatostatin gene transcription by cyclic adenosine monophosphate Metabolism: Clinical and Experimental. 45: 4-7. PMID 8769368  0.6
1995 Montminy M, Brindle P, Arias J, Ferreri K, Armstrong R. Regulation of somatostatin gene transcription by cAMP Ciba Foundation Symposium. 190: 7-20; discussion 20. PMID 7587654  0.6
1995 Carmen AA, Brindle PK, Park CS, Holland MJ. Transcriptional regulation by an upstream repression sequence from the yeast enolase gene ENO1. Yeast (Chichester, England). 11: 1031-43. PMID 7502579 DOI: 10.1002/yea.320111105  0.6
1995 Brindle P, Nakajima T, Montminy M. Multiple protein kinase A-regulated events are required for transcriptional induction by cAMP Proceedings of the National Academy of Sciences of the United States of America. 92: 10521-10525. PMID 7479832 DOI: 10.1073/pnas.92.23.10521  0.6
1994 Arias J, Alberts AS, Brindle P, Claret FX, Smeal T, Karin M, Feramisco J, Montminy M. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature. 370: 226-9. PMID 8028671 DOI: 10.1038/370226a0  0.6
1993 Hagiwara M, Brindle P, Harootunian A, Armstrong R, Rivier J, Vale W, Tsien R, Montminy MR. Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Molecular and Cellular Biology. 13: 4852-9. PMID 8336722 DOI: 10.1128/MCB.13.8.4852  0.6
1993 Brindle P, Linke S, Montminy M. Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors Nature. 364: 821-824. PMID 8102791 DOI: 10.1038/364821a0  0.6
1992 Brindle PK, Montminy MR. The CREB family of transcription activators. Current Opinion in Genetics & Development. 2: 199-204. PMID 1386267 DOI: 10.1016/S0959-437X(05)80274-6  0.6
1992 Hagiwara M, Alberts A, Brindle P, Meinkoth J, Feramisco J, Deng T, Karin M, Shenolikar S, Montminy M. Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell. 70: 105-13. PMID 1352481 DOI: 10.1016/0092-8674(92)90537-M  0.6
1990 Brindle PK, Holland JP, Willett CE, Innis MA, Holland MJ. Multiple factors bind the upstream activation sites of the yeast enolase genes ENO1 and ENO2: ABFI protein, like repressor activator protein RAP1, binds cis-acting sequences which modulate repression or activation of transcription. Molecular and Cellular Biology. 10: 4872-85. PMID 2201905  0.6
1990 Holland JP, Brindle PK, Holland MJ. Sequences within an upstream activation site in the yeast enolase gene ENO2 modulate repression of ENO2 expression in strains carrying a null mutation in the positive regulatory gene GCR1. Molecular and Cellular Biology. 10: 4863-71. PMID 2201904  0.6
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