| Year |
Citation |
Score |
| 2020 |
Winnay JN, Solheim MH, Sakaguchi M, Njølstad PR, Kahn CR. Inhibition of the PI 3-kinase pathway disrupts the unfolded protein response and reduces sensitivity to ER stress-dependent apoptosis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32744782 DOI: 10.1096/Fj.202000892R |
0.454 |
|
| 2018 |
Solheim MH, Winnay JN, Batista TM, Molven A, Njølstad PR, Kahn CR. Mice Carrying a Dominant-Negative Human PI 3-Kinase Mutation are Protected From Obesity and Hepatic Steatosis But Not Diabetes. Diabetes. PMID 29724723 DOI: 10.2337/Db17-1509 |
0.427 |
|
| 2017 |
Solheim MH, Clermont AC, Winnay JN, Hallstensen E, Molven A, Njølstad PR, Rødahl E, Kahn CR. Iris Malformation and Anterior Segment Dysgenesis in Mice and Humans With a Mutation in PI 3-Kinase. Investigative Ophthalmology & Visual Science. 58: 3100-3106. PMID 28632845 DOI: 10.1167/Iovs.16-21347 |
0.303 |
|
| 2017 |
Cai W, Sakaguchi M, Kleinridders A, Gonzalez-Del Pino G, Dreyfuss JM, O'Neill BT, Ramirez AK, Pan H, Winnay JN, Boucher J, Eck MJ, Kahn CR. Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nature Communications. 8: 14892. PMID 28345670 DOI: 10.1038/Ncomms14892 |
0.491 |
|
| 2017 |
Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, Gorden P, Kahn CR. Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature. PMID 28199304 DOI: 10.1038/Nature21365 |
0.315 |
|
| 2017 |
Sakaguchi M, Fujisaka S, Cai W, Winnay JN, Konishi M, O'Neill BT, Li M, García-Martín R, Takahashi H, Hu J, Kulkarni RN, Kahn CR. Adipocyte Dynamics and Reversible Metabolic Syndrome in Mice with an Inducible Adipocyte-Specific Deletion of the Insulin Receptor. Cell Metabolism. PMID 28065828 DOI: 10.1016/J.Cmet.2016.12.008 |
0.433 |
|
| 2016 |
Palsgaard J, Emanuelli B, Winnay JN, Sumara G, Karsenty G, Kahn CR. Cross-talk between insulin and Wnt signaling in preadipocytes. ROLE OF Wnt CO-RECEPTOR LDL RECEPTOR-RELATED PROTEIN-5 (LRP5). The Journal of Biological Chemistry. 291: 16878. PMID 27496960 DOI: 10.1074/Jbc.A111.337048 |
0.475 |
|
| 2016 |
Softic S, Boucher J, Solheim MH, Fujisaka S, Haering MF, Homan EP, Winnay J, Perez-Atayde AR, Kahn CR. Lipodystrophy Due to Adipose Tissue Specific Insulin Receptor Knockout Results in Progressive NAFLD. Diabetes. PMID 27207510 DOI: 10.2337/Db16-0213 |
0.346 |
|
| 2016 |
Winnay JN, Solheim MH, Dirice E, Sakaguchi M, Noh HL, Kang HJ, Takahashi H, Chudasama KK, Kim JK, Molven A, Kahn CR, Njølstad PR. PI3-kinase mutation linked to insulin and growth factor resistance in vivo. The Journal of Clinical Investigation. PMID 26974159 DOI: 10.1172/Jci84005 |
0.446 |
|
| 2014 |
Winnay JN, Dirice E, Liew CW, Kulkarni RN, Kahn CR. p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 111: 1192-7. PMID 24395790 DOI: 10.1073/Pnas.1322564111 |
0.407 |
|
| 2013 |
Chudasama KK, Winnay J, Johansson S, Claudi T, König R, Haldorsen I, Johansson B, Woo JR, Aarskog D, Sagen JV, Kahn CR, Molven A, Njølstad PR. SHORT syndrome with partial lipodystrophy due to impaired phosphatidylinositol 3 kinase signaling. American Journal of Human Genetics. 93: 150-7. PMID 23810379 DOI: 10.1016/J.Ajhg.2013.05.023 |
0.459 |
|
| 2013 |
Lee KY, Yamamoto Y, Boucher J, Winnay JN, Gesta S, Cobb J, Blüher M, Kahn CR. Shox2 is a molecular determinant of depot-specific adipocyte function. Proceedings of the National Academy of Sciences of the United States of America. 110: 11409-14. PMID 23798383 DOI: 10.1073/Pnas.1310331110 |
0.391 |
|
| 2013 |
Park K, Li Q, Rask-Madsen C, Mima A, Mizutani K, Winnay J, Maeda Y, D'Aquino K, White MF, Feener EP, King GL. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Molecular and Cellular Biology. 33: 3227-41. PMID 23775122 DOI: 10.1128/Mcb.00506-13 |
0.373 |
|
| 2012 |
Palsgaard J, Emanuelli B, Winnay JN, Sumara G, Karsenty G, Kahn CR. Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5). The Journal of Biological Chemistry. 287: 12016-26. PMID 22337886 DOI: 10.1074/Jbc.M111.337048 |
0.473 |
|
| 2011 |
Winnay JN, Kahn CR. PI 3-kinase regulatory subunits as regulators of the unfolded protein response. Methods in Enzymology. 490: 147-58. PMID 21266249 DOI: 10.1016/B978-0-12-385114-7.00009-X |
0.38 |
|
| 2010 |
Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR. The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. Cancer Research. 70: 5305-15. PMID 20530665 DOI: 10.1158/0008-5472.Can-09-3399 |
0.432 |
|
| 2010 |
Winnay JN, Boucher J, Mori MA, Ueki K, Kahn CR. A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nature Medicine. 16: 438-45. PMID 20348923 DOI: 10.1038/Nm.2121 |
0.473 |
|
| 2010 |
Sopasakis VR, Liu P, Suzuki R, Kondo T, Winnay J, Tran TT, Asano T, Smyth G, Sajan MP, Farese RV, Kahn CR, Zhao JJ. Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation. Cell Metabolism. 11: 220-30. PMID 20197055 DOI: 10.1016/J.Cmet.2010.02.002 |
0.443 |
|
| 2009 |
Assmann A, Ueki K, Winnay JN, Kadowaki T, Kulkarni RN. Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. Molecular and Cellular Biology. 29: 3219-28. PMID 19273608 DOI: 10.1128/Mcb.01489-08 |
0.454 |
|
| 2008 |
Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature. 454: 1000-4. PMID 18719589 DOI: 10.1038/Nature07221 |
0.422 |
|
| 2006 |
Winnay JN, Xu J, O'Malley BW, Hammer GD. Steroid receptor coactivator-1-deficient mice exhibit altered hypothalamic-pituitary-adrenal axis function. Endocrinology. 147: 1322-32. PMID 16339206 DOI: 10.1210/En.2005-0751 |
0.631 |
|
| 2006 |
Winnay JN, Hammer GD. Adrenocorticotropic hormone-mediated signaling cascades coordinate a cyclic pattern of steroidogenic factor 1-dependent transcriptional activation. Molecular Endocrinology (Baltimore, Md.). 20: 147-66. PMID 16109736 DOI: 10.1210/Me.2005-0215 |
0.673 |
|
| 2004 |
Kulkarni RN, Jhala US, Winnay JN, Krajewski S, Montminy M, Kahn CR. PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance. The Journal of Clinical Investigation. 114: 828-36. PMID 15372107 DOI: 10.1172/Jci21845 |
0.4 |
|
| 2004 |
Ross SE, Radomska HS, Wu B, Zhang P, Winnay JN, Bajnok L, Wright WS, Schaufele F, Tenen DG, MacDougald OA. Phosphorylation of C/EBPalpha inhibits granulopoiesis. Molecular and Cellular Biology. 24: 675-86. PMID 14701740 DOI: 10.1128/Mcb.24.2.675-686.2004 |
0.337 |
|
| 2003 |
Kulkarni RN, Almind K, Goren HJ, Winnay JN, Ueki K, Okada T, Kahn CR. Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice. Diabetes. 52: 1528-34. PMID 12765966 DOI: 10.2337/Diabetes.52.6.1528 |
0.402 |
|
| 2003 |
Gummow BM, Winnay JN, Hammer GD. Convergence of Wnt signaling and steroidogenic factor-1 (SF-1) on transcription of the rat inhibin alpha gene. The Journal of Biological Chemistry. 278: 26572-9. PMID 12732619 DOI: 10.1074/Jbc.M212677200 |
0.471 |
|
| 2000 |
Mauvais-Jarvis F, Virkamaki A, Michael MD, Winnay JN, Zisman A, Kulkarni RN, Kahn CR. A model to explore the interaction between muscle insulin resistance and β-cell dysfunction in the development of type 2 diabetes Diabetes. 49: 2126-2134. PMID 11118016 DOI: 10.2337/Diabetes.49.12.2126 |
0.381 |
|
| 2000 |
Winnay JN, Brüning JC, Burks DJ, Kahn CR. Gab-1-mediated IGF-1 signaling in IRS-1-deficient 3T3 fibroblasts Journal of Biological Chemistry. 275: 10545-10550. PMID 10744748 DOI: 10.1074/Jbc.275.14.10545 |
0.527 |
|
| 1999 |
Kulkarni RN, Winnay JN, Daniels M, Brüning JC, Flier SN, Hanahan D, Kahn CR. Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines. The Journal of Clinical Investigation. 104: R69-75. PMID 10606633 DOI: 10.1172/Jci8339 |
0.447 |
|
| 1999 |
Kulkarni RN, Brüning JC, Winnay JN, Postic C, Magnuson MA, Kahn CR. Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell. 96: 329-39. PMID 10025399 DOI: 10.1016/S0092-8674(00)80546-2 |
0.443 |
|
| 1998 |
Brüning JC, Michael MD, Winnay JN, Hayashi T, Hörsch D, Accili D, Goodyear LJ, Kahn CR. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance Molecular Cell. 2: 559-569. PMID 9844629 DOI: 10.1016/S1097-2765(00)80155-0 |
0.38 |
|
| 1997 |
Brüning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR. Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles Cell. 88: 561-572. PMID 9038347 DOI: 10.1016/S0092-8674(00)81896-6 |
0.425 |
|
| 1997 |
Brüning JC, Winnay J, Cheatham B, Kahn CR. Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Molecular and Cellular Biology. 17: 1513-21. PMID 9032279 DOI: 10.1128/Mcb.17.3.1513 |
0.455 |
|
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