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Douglas A. Melton - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Development
Website:
http://www.hsci.harvard.edu/node/723

211 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Leite NC, Pelayo GC, Melton DA. Genetic manipulation of stress pathways can protect stem-cell-derived islets from apoptosis in vitro. Stem Cell Reports. 17: 766-774. PMID 35245439 DOI: 10.1016/j.stemcr.2022.01.018  0.314
2021 Gerace D, Kenty JH, Melton DA. 209.2: Engineering Immune-evasive Human Stem Cell-derived Islet Cells. Transplantation. 105: S13. PMID 34908313 DOI: 10.1097/01.tp.0000804344.89342.14  0.32
2021 Sintov E, Gerace D, Melton DA. A human ESC line for efficient CRISPR editing of pluripotent stem cells. Stem Cell Research. 57: 102591. PMID 34741877 DOI: 10.1016/j.scr.2021.102591  0.421
2021 Gerace D, Boulanger KR, Hyoje-Ryu Kenty J, Melton DA. Generation of a heterozygous GAPDH-Luciferase human ESC line (HVRDe008-A-1) for in vivo monitoring of stem cells and their differentiated progeny. Stem Cell Research. 53: 102371. PMID 34088000 DOI: 10.1016/j.scr.2021.102371  0.419
2020 Cai EP, Ishikawa Y, Zhang W, Leite NC, Li J, Hou S, Kiaf B, Hollister-Lock J, Yilmaz NK, Schiffer CA, Melton DA, Kissler S, Yi P. Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes. Nature Metabolism. PMID 32719542 DOI: 10.1038/s42255-020-0254-1  0.538
2020 Leite NC, Sintov E, Meissner TB, Brehm MA, Greiner DL, Harlan DM, Melton DA. Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells. Cell Reports. 32: 107894. PMID 32668238 DOI: 10.1016/j.celrep.2020.107894  0.479
2020 Rasouli N, Melton DA, Alvarez-Dominguez JR. Purification of Live Stem-Cell-Derived Islet Lineage Intermediates. Current Protocols in Stem Cell Biology. 53: e111. PMID 32521122 DOI: 10.1002/cpsc.111  0.49
2020 Davis JC, Alves TC, Helman A, Chen JC, Kenty JH, Cardone RL, Liu DR, Kibbey RG, Melton DA. Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis. Cell Reports. 31: 107623. PMID 32402282 DOI: 10.1016/J.Celrep.2020.107623  0.415
2020 Peterson QP, Veres A, Chen L, Slama MQ, Kenty JHR, Hassoun S, Brown MR, Dou H, Duffy CD, Zhou Q, Matveyenko AV, Tyrberg B, Sörhede-Winzell M, Rorsman P, Melton DA. A method for the generation of human stem cell-derived alpha cells. Nature Communications. 11: 2241. PMID 32382023 DOI: 10.1038/S41467-020-16049-3  0.782
2020 Helman A, Cangelosi AL, Davis JC, Pham Q, Rothman A, Faust AL, Straubhaar JR, Sabatini DM, Melton DA. A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion. Cell Metabolism. PMID 32375022 DOI: 10.1016/j.cmet.2020.04.004  0.379
2020 Helman A, Melton DA. A Stem Cell Approach to Cure Type 1 Diabetes. Cold Spring Harbor Perspectives in Biology. PMID 32122884 DOI: 10.1101/cshperspect.a035741  0.426
2020 Rosado-Olivieri EA, Aigha II, Kenty JH, Melton DA. Identification of a LIF-Responsive, Replication-Competent Subpopulation of Human β Cells. Cell Metabolism. PMID 31928884 DOI: 10.1016/j.cmet.2019.12.009  0.444
2019 Alvarez-Dominguez JR, Donaghey J, Rasouli N, Kenty JHR, Helman A, Charlton J, Straubhaar JR, Meissner A, Melton DA. Circadian Entrainment Triggers Maturation of Human In Vitro Islets. Cell Stem Cell. PMID 31839570 DOI: 10.1016/J.Stem.2019.11.011  0.437
2019 Davis JC, Helman A, Rivera-Feliciano J, Langston CM, Engquist EN, Melton DA. Live Cell Monitoring and Enrichment of Stem Cell-Derived β Cells Using Intracellular Zinc Content as a Population Marker. Current Protocols in Stem Cell Biology. 51: e99. PMID 31756031 DOI: 10.1002/cpsc.99  0.83
2019 Garbern JC, Helman A, Sereda R, Sarikhani M, Ahmed A, Escalante GO, Ogurlu R, Kim SL, Zimmerman JF, Cho A, MacQueen L, Bezzerides VJ, Parker KK, Melton DA, Lee RT. Inhibition of mTOR Signaling Enhances Maturation of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells via p53-Induced Quiescence. Circulation. PMID 31707831 DOI: 10.1161/Circulationaha.119.044205  0.403
2019 Kotliar D, Veres A, Nagy MA, Tabrizi S, Hodis E, Melton DA, Sabeti PC. Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq. Elife. 8. PMID 31282856 DOI: 10.7554/eLife.43803  0.403
2019 Sharon N, Vanderhooft J, Straubhaar J, Mueller J, Chawla R, Zhou Q, Engquist EN, Trapnell C, Gifford DK, Melton DA. Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development. Cell Reports. 27: 2281-2291.e5. PMID 31116975 DOI: 10.1016/J.Celrep.2019.04.083  0.517
2019 Veres A, Faust AL, Bushnell HL, Engquist EN, Kenty JH, Harb G, Poh YC, Sintov E, Gürtler M, Pagliuca FW, Peterson QP, Melton DA. Charting cellular identity during human in vitro β-cell differentiation. Nature. PMID 31068696 DOI: 10.1038/s41586-019-1168-5  0.817
2019 Han X, Wang M, Duan S, Franco PJ, Kenty JH, Hedrick P, Xia Y, Allen A, Ferreira LMR, Strominger JL, Melton DA, Meissner TB, Cowan CA. Generation of hypoimmunogenic human pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 31040209 DOI: 10.1073/Pnas.1902566116  0.642
2019 Rosado-Olivieri EA, Anderson K, Kenty JH, Melton DA. YAP inhibition enhances the differentiation of functional stem cell-derived insulin-producing β cells. Nature Communications. 10: 1464. PMID 30931946 DOI: 10.1038/s41467-019-09404-6  0.504
2019 Chien KR, Frisén J, Fritsche-Danielson R, Melton DA, Murry CE, Weissman IL. Regenerating the field of cardiovascular cell therapy. Nature Biotechnology. PMID 30778231 DOI: 10.1038/S41587-019-0042-1  0.302
2019 Alagpulinsa DA, Cao JJL, Driscoll RK, Sîrbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns TA, Markmann JF, Melton DA, Poznansky MC. Alginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 30748094 DOI: 10.1111/Ajt.15308  0.441
2019 Tsai SL, Baselga-Garriga C, Melton DA. Blastemal progenitors modulate immune signaling during early limb regeneration. Development (Cambridge, England). 146. PMID 30602532 DOI: 10.1242/dev.169128  0.42
2019 Kotliar D, Veres A, Nagy MA, Tabrizi S, Hodis E, Melton DA, Sabeti PC. Author response: Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq Elife. DOI: 10.7554/Elife.43803.044  0.4
2019 HELMAN A, MELTON D. 331-LB: A Switch in Nutrient Sensing Controls Functional Maturation of Pancreatic Beta Cells Diabetes. 68: 331-LB. DOI: 10.2337/DB19-331-LB  0.402
2018 Mahmoud AI, Galdos FX, Dinan KA, Jedrychowski MP, Davis JC, Vujic A, Rachmin I, Shigley C, Pancoast JR, Lee S, Hollister-Lock J, MacGillivray CM, Gygi SP, Melton DA, Weir GC, et al. Apolipoprotein E is a pancreatic extracellular factor that maintains mature β-cell gene expression. Plos One. 13: e0204595. PMID 30303984 DOI: 10.1371/Journal.Pone.0204595  0.461
2018 Zhou Q, Melton DA. Author Correction: Pancreas regeneration. Nature. PMID 29925956 DOI: 10.1038/s41586-018-0294-9  0.606
2018 Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, et al. Report of the Key Opinion Leaders Meeting on Stem Cell-Derived Beta Cells. Transplantation. PMID 29781950 DOI: 10.1097/Tp.0000000000002217  0.79
2018 Zhou Q, Melton DA. Pancreas regeneration. Nature. 557: 351-358. PMID 29769672 DOI: 10.1038/s41586-018-0088-0  0.576
2018 Ma H, Wert KJ, Shvartsman D, Melton DA, Jaenisch R. Establishment of human pluripotent stem cell-derived pancreatic β-like cells in the mouse pancreas. Proceedings of the National Academy of Sciences of the United States of America. PMID 29599125 DOI: 10.1073/Pnas.1702059115  0.462
2016 Yi P, Park JS, Melton DA. Retraction Notice to: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation. Cell. PMID 28038792 DOI: 10.1016/j.cell.2016.12.017  0.588
2016 Baron M, Veres A, Wolock SL, Faust AL, Gaujoux R, Vetere A, Ryu JH, Wagner BK, Shen-Orr SS, Klein AM, Melton DA, Yanai I. A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure. Cell Systems. PMID 27667365 DOI: 10.1016/J.Cels.2016.08.011  0.506
2016 Millman JR, Xie C, Van Dervort A, Gürtler M, Pagliuca FW, Melton DA. Corrigendum: Generation of stem cell-derived β-cells from patients with type 1 diabetes. Nature Communications. 7: 12379. PMID 27487970 DOI: 10.1038/ncomms12379  0.396
2016 Cox AR, Barrandon O, Cai EP, Rios JS, Chavez J, Bonnyman CW, Lam CJ, Yi P, Melton DA, Kushner JA. Resolving Discrepant Findings on ANGPTL8 in β-Cell Proliferation: A Collaborative Approach to Resolving the Betatrophin Controversy. Plos One. 11: e0159276. PMID 27410263 DOI: 10.1371/journal.pone.0159276  0.584
2016 Millman JR, Xie C, Van Dervort A, Gürtler M, Pagliuca FW, Melton DA. Generation of stem cell-derived β-cells from patients with type 1 diabetes. Nature Communications. 7: 11463. PMID 27163171 DOI: 10.1038/ncomms11463  0.407
2016 Vegas AJ, Veiseh O, G M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, ... ... Melton DA, et al. Corrigendum: Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nature Medicine. 22: 446. PMID 27050590 DOI: 10.1038/Nm0416-446E  0.404
2016 Melton DA. Applied Developmental Biology: Making Human Pancreatic Beta Cells for Diabetics. Current Topics in Developmental Biology. 117: 65-73. PMID 26969972 DOI: 10.1016/bs.ctdb.2015.11.013  0.456
2016 Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q. Reprogrammed Stomach Tissue as a Renewable Source of Functional β Cells for Blood Glucose Regulation. Cell Stem Cell. PMID 26908146 DOI: 10.1016/J.Stem.2016.01.003  0.651
2016 Vegas AJ, Veiseh O, Gürtler M, Millman JR, Pagliuca FW, Bader AR, Doloff JC, Li J, Chen M, Olejnik K, Tam HH, Jhunjhunwala S, Langan E, Aresta-Dasilva S, Gandham S, ... ... Melton DA, et al. Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nature Medicine. PMID 26808346 DOI: 10.1038/Nm.4030  0.423
2015 Ben-Zvi D, Barrandon O, Hadley S, Blum B, Peterson QP, Melton DA. Angptl4 links α-cell proliferation following glucagon receptor inhibition with adipose tissue triglyceride metabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 26621734 DOI: 10.1073/Pnas.1513872112  0.788
2015 Chetty S, Engquist EN, Mehanna E, Lui KO, Tsankov AM, Melton DA. A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation. The Journal of Cell Biology. 210: 1257-68. PMID 26416968 DOI: 10.1083/Jcb.201502035  0.458
2015 Kenty JH, Melton DA. Testing pancreatic islet function at the single cell level by calcium influx with associated marker expression. Plos One. 10: e0122044. PMID 25853429 DOI: 10.1371/journal.pone.0122044  0.439
2015 Ben-Zvi D, Melton DA. Modeling human nutrition using human embryonic stem cells. Cell. 161: 12-7. PMID 25815980 DOI: 10.1016/J.Cell.2015.02.039  0.677
2015 Chetty S, Engquist E, Mehanna E, Lui K, Tsankov A, Melton D. A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation The Journal of Experimental Medicine. 212: 21211OIA91. DOI: 10.1084/jem.21211OIA91  0.369
2014 Yi P, Park JS, Melton DA. Perspectives on the activities of ANGPTL8/betatrophin. Cell. 159: 467-8. PMID 25417096 DOI: 10.1016/j.cell.2014.09.028  0.557
2014 Pagliuca FW, Millman JR, Gürtler M, Segel M, Van Dervort A, Ryu JH, Peterson QP, Greiner D, Melton DA. Generation of functional human pancreatic β cells in vitro. Cell. 159: 428-39. PMID 25303535 DOI: 10.1016/J.Cell.2014.09.040  0.799
2014 Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, Davis JC, Peterson QP, Rubin LL, Melton DA. Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway. Elife. 3: e02809. PMID 25233132 DOI: 10.7554/Elife.02809  0.806
2014 Li W, Nakanishi M, Zumsteg A, Shear M, Wright C, Melton DA, Zhou Q. In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes. Elife. 3: e01846. PMID 24714494 DOI: 10.7554/eLife.01846.027  0.652
2014 Hrvatin S, Deng F, O'Donnell CW, Gifford DK, Melton DA. MARIS: method for analyzing RNA following intracellular sorting. Plos One. 9: e89459. PMID 24594682 DOI: 10.1371/Journal.Pone.0089459  0.746
2014 Hrvatin S, O'Donnell CW, Deng F, Millman JR, Pagliuca FW, DiIorio P, Rezania A, Gifford DK, Melton DA. Differentiated human stem cells resemble fetal, not adult, β cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 3038-43. PMID 24516164 DOI: 10.1073/Pnas.1400709111  0.795
2014 Blum B, Roose AN, Barrandon O, Maehr R, Arvanites AC, Davidow LS, Davis JC, Peterson QP, Rubin LL, Melton DA. Author response: Reversal of β cell de-differentiation by a small molecule inhibitor of the TGFβ pathway Elife. DOI: 10.7554/Elife.02809.018  0.786
2014 Li W, Nakanishi M, Zumsteg A, Shear M, Wright C, Melton DA, Zhou Q. Re: In vivo reprogramming of pancreatic acinar cells to three islet endocrine subtypes Elife. 2014. DOI: 10.7554/eLife.01846.028  0.611
2013 Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA. Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. Stem Cells (Dayton, Ohio). 31: 2833-41. PMID 23765749 DOI: 10.1002/Stem.1445  0.795
2013 Pagliuca FW, Melton DA. How to make a functional β-cell. Development (Cambridge, England). 140: 2472-83. PMID 23715541 DOI: 10.1242/dev.093187  0.515
2013 Yi P, Park JS, Melton DA. Betatrophin: a hormone that controls pancreatic β cell proliferation. Cell. 153: 747-58. PMID 23623304 DOI: 10.1016/j.cell.2013.04.008  0.603
2013 Chetty S, Pagliuca FW, Honore C, Kweudjeu A, Rezania A, Melton DA. A simple tool to improve pluripotent stem cell differentiation. Nature Methods. 10: 553-6. PMID 23584186 DOI: 10.1038/Nmeth.2442  0.486
2013 Chen AE, Borowiak M, Sherwood RI, Kweudjeu A, Melton DA. Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation. Development (Cambridge, England). 140: 675-86. PMID 23293299 DOI: 10.1242/Dev.085431  0.78
2013 Carolan PJ, Melton DA. New findings in pancreatic and intestinal endocrine development to advance regenerative medicine. Current Opinion in Endocrinology, Diabetes, and Obesity. 20: 1-7. PMID 23249759 DOI: 10.1097/MED.0b013e32835bc380  0.503
2013 Chetty S, Pagliuca FW, Honore C, Melton DA. A protocol to improve pluripotent stem cell differentiation Protocol Exchange. DOI: 10.1038/Protex.2013.050  0.433
2013 Yamanaka S, Wagers A, Muotri A, Srivastava D, Melton D, Blanpain C, Gurdon J, Fuchs E, Jaenisch R. XStem cells in translation Cell. 153: X1177-1179. DOI: 10.1016/J.Cell.2013.05.036  0.564
2013 Dor Y, Melton DA. Pancreatic Stem Cells Handbook of Stem Cells. 2: 819-826. DOI: 10.1016/B978-0-12-385942-6.00068-8  0.627
2012 Sneddon JB, Borowiak M, Melton DA. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme. Nature. 491: 765-8. PMID 23041930 DOI: 10.1038/Nature11463  0.515
2012 Blum B, Hrvatin SS, Schuetz C, Bonal C, Rezania A, Melton DA. Functional beta-cell maturation is marked by an increased glucose threshold and by expression of urocortin 3. Nature Biotechnology. 30: 261-4. PMID 22371083 DOI: 10.1038/Nbt.2141  0.813
2012 Annes JP, Ryu JH, Lam K, Carolan PJ, Utz K, Hollister-Lock J, Arvanites AC, Rubin LL, Weir G, Melton DA. Adenosine kinase inhibition selectively promotes rodent and porcine islet β-cell replication. Proceedings of the National Academy of Sciences of the United States of America. 109: 3915-20. PMID 22345561 DOI: 10.1073/pnas.1201149109  0.43
2011 Egli D, Chen AE, Saphier G, Powers D, Alper M, Katz K, Berger B, Goland R, Leibel RL, Melton DA, Eggan K. Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell. 9: 293-4. PMID 21982228 DOI: 10.1016/J.Stem.2011.08.002  0.637
2011 Egli D, Chen AE, Saphier G, Ichida J, Fitzgerald C, Go KJ, Acevedo N, Patel J, Baetscher M, Kearns WG, Goland R, Leibel RL, Melton DA, Eggan K. Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nature Communications. 2: 488. PMID 21971503 DOI: 10.1038/Ncomms1503  0.624
2011 Sherwood RI, Maehr R, Mazzoni EO, Melton DA. Wnt signaling specifies and patterns intestinal endoderm. Mechanisms of Development. 128: 387-400. PMID 21854845 DOI: 10.1016/J.Mod.2011.07.005  0.811
2011 Melton DA. Using stem cells to study and possibly treat type 1 diabetes. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 366: 2307-11. PMID 21727136 DOI: 10.1098/rstb.2011.0019  0.431
2011 Cohen DE, Melton D. Turning straw into gold: directing cell fate for regenerative medicine. Nature Reviews. Genetics. 12: 243-52. PMID 21386864 DOI: 10.1038/nrg2938  0.494
2010 Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K. Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes & Development. 24: 312-26. PMID 20123909 DOI: 10.1101/Gad.1833510  0.824
2010 Chen S, Rajagopal J, Zhou Q, Melton DA, Koh A, Senior P, Shapiro AMJ, Barbu AR, Welsh N. Other Future Directions Textbook of Diabetes: Fourth Edition. 1045-1069. DOI: 10.1002/9781444324808.ch61  0.57
2009 Borowiak M, Melton DA. How to make beta cells? Current Opinion in Cell Biology. 21: 727-32. PMID 19781928 DOI: 10.1016/j.ceb.2009.08.006  0.448
2009 Maehr R, Chen S, Snitow M, Ludwig T, Yagasaki L, Goland R, Leibel RL, Melton DA. Generation of pluripotent stem cells from patients with type 1 diabetes. Proceedings of the National Academy of Sciences of the United States of America. 106: 15768-73. PMID 19720998 DOI: 10.1073/Pnas.0906894106  0.755
2009 Brennand K, Melton D. Slow and steady is the key to β-cell replication Journal of Cellular and Molecular Medicine. 13: 472-487. PMID 19379145 DOI: 10.1111/J.1582-4934.2008.00635.X  0.624
2009 Guseh JS, Bores SA, Stanger BZ, Zhou Q, Anderson WJ, Melton DA, Rajagopal J. Notch signaling promotes airway mucous metaplasia and inhibits alveolar development. Development (Cambridge, England). 136: 1751-9. PMID 19369400 DOI: 10.1242/Dev.029249  0.809
2009 Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell. 4: 348-58. PMID 19341624 DOI: 10.1016/J.Stem.2009.01.014  0.758
2009 Chen S, Borowiak M, Fox JL, Maehr R, Osafune K, Davidow L, Lam K, Peng LF, Schreiber SL, Rubin LL, Melton D. A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nature Chemical Biology. 5: 258-65. PMID 19287398 DOI: 10.1038/Nchembio.154  0.776
2009 Chen AE, Egli D, Niakan K, Deng J, Akutsu H, Yamaki M, Cowan C, Fitz-Gerald C, Zhang K, Melton DA, Eggan K. Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell. 4: 103-6. PMID 19200798 DOI: 10.1016/J.Stem.2008.12.001  0.759
2009 Sherwood RI, Chen TY, Melton DA. Transcriptional dynamics of endodermal organ formation. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 29-42. PMID 19097184 DOI: 10.1002/Dvdy.21810  0.708
2009 Lanza R, Gearhart J, Hogan B, Melton D, Pedersen R, Thomas ED, Thomson J, Wilmut SI. Essentials of Stem Cell Biology Essentials of Stem Cell Biology 0.353
2008 Zhou Q, Melton DA. Pathways to new beta cells. Cold Spring Harbor Symposia On Quantitative Biology. 73: 175-81. PMID 19478324 DOI: 10.1101/sqb.2008.73.002  0.595
2008 Gurdon JB, Melton DA. Nuclear reprogramming in cells. Science (New York, N.Y.). 322: 1811-5. PMID 19095934 DOI: 10.1126/Science.1160810  0.636
2008 Zhou Q, Melton DA. Extreme makeover: converting one cell into another. Cell Stem Cell. 3: 382-8. PMID 18940730 DOI: 10.1016/j.stem.2008.09.015  0.64
2008 Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S, Muhlestein W, Melton DA. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nature Biotechnology. 26: 1269-75. PMID 18849973 DOI: 10.1038/Nbt.1502  0.823
2008 Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature. 455: 627-32. PMID 18754011 DOI: 10.1038/Nature07314  0.835
2008 Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, Melton DA. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nature Biotechnology. 26: 795-7. PMID 18568017 DOI: 10.1038/Nbt1418  0.8
2008 Rajagopal J, Carroll TJ, Guseh JS, Bores SA, Blank LJ, Anderson WJ, Yu J, Zhou Q, McMahon AP, Melton DA. Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development (Cambridge, England). 135: 1625-34. PMID 18367557 DOI: 10.1242/Dev.015495  0.795
2008 Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, Sato Y, Cowan CA, Chien KR, Melton DA. Marked differences in differentiation propensity among human embryonic stem cell lines. Nature Biotechnology. 26: 313-5. PMID 18278034 DOI: 10.1038/Nbt1383  0.68
2008 Dor Y, Melton DA. Facultative endocrine progenitor cells in the adult pancreas. Cell. 132: 183-4. PMID 18243094 DOI: 10.1016/J.Cell.2008.01.004  0.661
2008 Anderson WJ, Zhou Q, Alcalde V, Kaneko OF, Blank LJ, Sherwood RI, Guseh JS, Rajagopal J, Melton DA. Genetic targeting of the endoderm with claudin-6CreER. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 237: 504-12. PMID 18213590 DOI: 10.1002/Dvdy.21437  0.822
2007 Chen AE, Melton DA. Derivation of human embryonic stem cells by immunosurgery. Journal of Visualized Experiments : Jove. 574. PMID 18989406 DOI: 10.3791/574  0.479
2007 Zhou Q, Chipperfield H, Melton DA, Wong WH. A gene regulatory network in mouse embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 16438-43. PMID 17940043 DOI: 10.1073/pnas.0701014104  0.369
2007 Nir T, Melton DA, Dor Y. Recovery from diabetes in mice by beta cell regeneration. The Journal of Clinical Investigation. 117: 2553-61. PMID 17786244 DOI: 10.1172/Jci32959  0.637
2007 Zhou Q, Law AC, Rajagopal J, Anderson WJ, Gray PA, Melton DA. A multipotent progenitor domain guides pancreatic organogenesis. Developmental Cell. 13: 103-14. PMID 17609113 DOI: 10.1016/J.Devcel.2007.06.001  0.822
2007 Brennand K, Huangfu D, Melton D. All beta cells contribute equally to islet growth and maintenance. Plos Biology. 5: e163. PMID 17535113 DOI: 10.1371/Journal.Pbio.0050163  0.784
2007 Sherwood RI, Jitianu C, Cleaver O, Shaywitz DA, Lamenzo JO, Chen AE, Golub TR, Melton DA. Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Developmental Biology. 304: 541-55. PMID 17328885 DOI: 10.1016/J.Ydbio.2007.01.011  0.728
2007 Stanger BZ, Tanaka AJ, Melton DA. Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature. 445: 886-91. PMID 17259975 DOI: 10.1038/Nature05537  0.371
2007 Greenwood AL, Li S, Jones K, Melton DA. Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate. Mechanisms of Development. 124: 97-107. PMID 17196797 DOI: 10.1016/j.mod.2006.11.002  0.722
2007 Brennand K, Huangfu D, Melton D. Correction: All ß Cells Contribute Equally to Islet Growth and Maintenance Plos Biology. 5: e240. DOI: 10.1371/Journal.Pbio.0050240  0.741
2007 Osafune K, Chen AE, Melton DA. Part A: Directed Differentiation of Human Embryonic Stem Cells into Early Endoderm Cells Human Embryonic Stem Cells: the Practical Handbook. 179-186. DOI: 10.1002/9780470511619.ch12a  0.401
2006 Akutsu H, Cowan CA, Melton D. Human Embryonic Stem Cells Methods in Enzymology. 418: 78-92. PMID 17141030 DOI: 10.1016/S0076-6879(06)18005-2  0.694
2006 Melton DA. Reversal of type 1 diabetes in mice. The New England Journal of Medicine. 355: 89-90. PMID 16823003 DOI: 10.1056/NEJMcibr062559  0.346
2006 Lee TI, Jenner RG, Boyer LA, Guenther MG, Levine SS, Kumar RM, Chevalier B, Johnstone SE, Cole MF, Isono K, Koseki H, Fuchikami T, Abe K, Murray HL, Zucker JP, ... ... Melton DA, et al. Control of developmental regulators by Polycomb in human embryonic stem cells. Cell. 125: 301-13. PMID 16630818 DOI: 10.1016/J.Cell.2006.02.043  0.485
2006 Nikolova G, Jabs N, Konstantinova I, Domogatskaya A, Tryggvason K, Sorokin L, Fässler R, Gu G, Gerber HP, Ferrara N, Melton DA, Lammert E. The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation. Developmental Cell. 10: 397-405. PMID 16516842 DOI: 10.1016/j.devcel.2006.01.015  0.404
2006 Yang X, Eggan K, Seidel G, Jaenisch R, Melton D. A simple system of checks and balances to cut fraud. Nature. 439: 782. PMID 16482128 DOI: 10.1038/439782B  0.498
2005 Murtaugh LC, Law AC, Dor Y, Melton DA. Beta-catenin is essential for pancreatic acinar but not islet development. Development (Cambridge, England). 132: 4663-74. PMID 16192304 DOI: 10.1242/Dev.02063  0.651
2005 Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 8: 185-95. PMID 16169464 DOI: 10.1016/J.Ccr.2005.07.015  0.762
2005 Boyer LA, Lee TI, Cole MF, Johnstone SE, Levine SS, Zucker JP, Guenther MG, Kumar RM, Murray HL, Jenner RG, Gifford DK, Melton DA, Jaenisch R, Young RA. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 122: 947-56. PMID 16153702 DOI: 10.1016/J.Cell.2005.08.020  0.466
2005 Cowan CA, Atienza J, Melton DA, Eggan K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science (New York, N.Y.). 309: 1369-73. PMID 16123299 DOI: 10.1126/Science.1116447  0.792
2005 Stanger BZ, Datar R, Murtaugh LC, Melton DA. Direct regulation of intestinal fate by Notch. Proceedings of the National Academy of Sciences of the United States of America. 102: 12443-8. PMID 16107537 DOI: 10.1073/Pnas.0505690102  0.417
2004 Melton DA, Daley GQ, Jennings CG. Altered nuclear transfer in stem-cell research - a flawed proposal. The New England Journal of Medicine. 351: 2791-2. PMID 15625329 DOI: 10.1056/Nejmp048348  0.4
2004 Hansson M, Tonning A, Frandsen U, Petri A, Rajagopal J, Englund MCO, Heller RS, Håkansson J, Fleckner J, Sköld HN, Melton D, Semb H, Serup P. Artifactual insulin release from differentiated embryonic stem cells Diabetes. 53: 2603-2609. PMID 15448090 DOI: 10.2337/Diabetes.53.10.2603  0.7
2004 Dor Y, Melton DA. How important are adult stem cells for tissue maintenance? Cell Cycle (Georgetown, Tex.). 3: 1104-6. PMID 15326371 DOI: 10.4161/Cc.3.9.1096  0.674
2004 Annerén C, Cowan CA, Melton DA. The Src family of tyrosine kinases is important for embryonic stem cell self-renewal. The Journal of Biological Chemistry. 279: 31590-8. PMID 15148312 DOI: 10.1074/jbc.M403547200  0.644
2004 Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature. 429: 41-6. PMID 15129273 DOI: 10.1038/Nature02520  0.778
2004 Cowan CA, Klimanskaya I, McMahon J, Atienza J, Witmyer J, Zucker JP, Wang S, Morton CC, McMahon AP, Powers D, Melton DA. Derivation of embryonic stem-cell lines from human blastocysts. The New England Journal of Medicine. 350: 1353-6. PMID 14999088 DOI: 10.1056/Nejmsr040330  0.683
2004 Gu G, Wells JM, Dombkowski D, Preffer F, Aronow B, Melton DA. Global expression analysis of gene regulatory pathways during endocrine pancreatic development. Development (Cambridge, England). 131: 165-79. PMID 14660441 DOI: 10.1242/dev.00921  0.479
2003 Murtaugh LC, Stanger BZ, Kwan KM, Melton DA. Notch signaling controls multiple steps of pancreatic differentiation. Proceedings of the National Academy of Sciences of the United States of America. 100: 14920-5. PMID 14657333 DOI: 10.1073/Pnas.2436557100  0.481
2003 Murtaugh LC, Melton DA. Genes, signals, and lineages in pancreas development. Annual Review of Cell and Developmental Biology. 19: 71-89. PMID 14570564 DOI: 10.1146/annurev.cellbio.19.111301.144752  0.47
2003 Kumar M, Melton D. Pancreas specification: A budding question Current Opinion in Genetics and Development. 13: 401-407. PMID 12888014 DOI: 10.1016/S0959-437X(03)00089-3  0.733
2003 Kumar M, Jordan N, Melton D, Grapin-Botton A. Signals from lateral plate mesoderm instruct endoderm toward a pancreatic fate Developmental Biology. 259: 109-122. PMID 12812792 DOI: 10.1016/S0012-1606(03)00183-0  0.762
2003 Cleaver O, Melton DA. Endothelial signaling during development. Nature Medicine. 9: 661-8. PMID 12778164 DOI: 10.1038/nm0603-661  0.379
2003 Brivanlou AH, Gage FH, Jaenisch R, Jessell T, Melton D, Rossant J. Stem cells. Setting standards for human embryonic stem cells. Science (New York, N.Y.). 300: 913-6. PMID 12738841 DOI: 10.1126/Science.1082940  0.724
2003 Chiang MK, Melton DA. Single-cell transcript analysis of pancreas development. Developmental Cell. 4: 383-93. PMID 12636919 DOI: 10.1016/S1534-5807(03)00035-2  0.497
2003 Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA. Insulin staining of ES cell progeny from insulin uptake. Science (New York, N.Y.). 299: 363. PMID 12532008 DOI: 10.1126/science.1077838  0.718
2003 Lammert E, Cleaver O, Melton D. Role of endothelial cells in early pancreas and liver development Mechanisms of Development. 120: 59-64. PMID 12490296 DOI: 10.1016/S0925-4773(02)00332-5  0.391
2003 Gu G, Brown JR, Melton DA. Direct lineage tracing reveals the ontogeny of pancreatic cell fates during mouse embryogenesis. Mechanisms of Development. 120: 35-43. PMID 12490294 DOI: 10.1016/S0925-4773(02)00330-1  0.719
2002 Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA. "Stemness": transcriptional profiling of embryonic and adult stem cells. Science (New York, N.Y.). 298: 597-600. PMID 12228720 DOI: 10.1126/Science.1072530  0.494
2002 Scearce LM, Brestelli JE, McWeeney SK, Lee CS, Mazzarelli J, Pinney DF, Pizarro A, Stoeckert CJ, Clifton SW, Permutt MA, Brown J, Melton DA, Kaestner KH. Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research. Diabetes. 51: 1997-2004. PMID 12086925 DOI: 10.2337/Diabetes.51.7.1997  0.579
2002 Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development (Cambridge, England). 129: 2447-57. PMID 11973276  0.411
2002 Fishman MP, Melton DA. Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells. The International Journal of Developmental Biology. 46: 201-7. PMID 11934148 DOI: 10.1387/ijdb.011552  0.5
2001 Lammert E, Cleaver O, Melton D. Induction of Pancreatic Differentiation by Signals from Blood Vessels Science. 294: 564-567. PMID 11577200 DOI: 10.1126/Science.1064344  0.338
2001 Grapin-Botton A, Majithia AR, Melton DA. Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes. Genes & Development. 15: 444-54. PMID 11230152 DOI: 10.1101/gad.846001  0.487
2000 Hebrok M, Kim SK, St Jacques B, McMahon AP, Melton DA. Regulation of pancreas development by hedgehog signaling. Development (Cambridge, England). 127: 4905-13. PMID 11044404  0.614
2000 Schuldiner M, Yanuka O, Itskovitz-Eldor J, Melton DA, Benvenisty N. Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 11307-12. PMID 11027332 DOI: 10.1073/Pnas.97.21.11307  0.655
2000 Kim SK, Hebrok M, Li E, Oh SP, Schrewe H, Harmon EB, Lee JS, Melton DA. Activin receptor patterning of foregut organogenesis. Genes & Development. 14: 1866-71. PMID 10921901 DOI: 10.1101/Gad.14.15.1866  0.617
2000 Kelly OG, Melton DA. Development of the pancreas in Xenopus laevis. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 218: 615-27. PMID 10906780 DOI: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1027>3.0.CO;2-8  0.375
2000 Lammert E, Brown J, Melton DA. Notch gene expression during pancreatic organogenesis. Mechanisms of Development. 94: 199-203. PMID 10842072 DOI: 10.1016/S0925-4773(00)00317-8  0.68
2000 Ramalho-Santos M, Melton DA, McMahon AP. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development (Cambridge, England). 127: 2763-72. PMID 10821773  0.304
1999 Wells JM, Melton DA. Vertebrate endoderm development. Annual Review of Cell and Developmental Biology. 15: 393-410. PMID 10611967 DOI: 10.1146/annurev.cellbio.15.1.393  0.376
1999 Hebrok M, Kim SK, Melton DA. Screening for novel pancreatic genes expressed during embryogenesis. Diabetes. 48: 1550-6. PMID 10426372 DOI: 10.2337/Diabetes.48.8.1550  0.603
1998 Kim SK, Melton DA. Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 95: 13036-41. PMID 9789036 DOI: 10.1073/pnas.95.22.13036  0.408
1998 Henry GL, Melton DA. Mixer, a homeobox gene required for endoderm development. Science (New York, N.Y.). 281: 91-6. PMID 9651252 DOI: 10.1126/science.281.5373.91  0.437
1998 Hebrok M, Kim SK, Melton DA. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes & Development. 12: 1705-13. PMID 9620856 DOI: 10.1101/Gad.12.11.1705  0.636
1997 Kim SK, Hebrok M, Melton DA. Pancreas development in the chick embryo. Cold Spring Harbor Symposia On Quantitative Biology. 62: 377-83. PMID 9598372 DOI: 10.1101/Sqb.1997.062.01.045  0.584
1997 Kim SK, Hebrok M, Melton DA. Notochord to endoderm signaling is required for pancreas development. Development (Cambridge, England). 124: 4243-52. PMID 9334273  0.606
1997 Joseph EM, Melton DA. Xnr4: a Xenopus nodal-related gene expressed in the Spemann organizer. Developmental Biology. 184: 367-72. PMID 9133442 DOI: 10.1006/dbio.1997.8510  0.353
1997 Hemmati-Brivanlou A, Melton D. Vertebrate embryonic cells will become nerve cells unless told otherwise. Cell. 88: 13-7. PMID 9019398 DOI: 10.1016/S0092-8674(00)81853-X  0.406
1996 Derynck R, Gelbart WM, Harland RM, Heldin CH, Kern SE, Massagué J, Melton DA, Mlodzik M, Padgett RW, Roberts AB, Smith J, Thomsen GH, Vogelstein B, Wang XF. Nomenclature: vertebrate mediators of TGFbeta family signals. Cell. 87: 173. PMID 8861901 DOI: 10.1016/S0092-8674(00)81335-5  0.69
1996 Reilly KM, Melton DA. Short-range signaling by candidate morphogens of the TGF beta family and evidence for a relay mechanism of induction. Cell. 86: 743-54. PMID 8797821 DOI: 10.1016/S0092-8674(00)80149-X  0.438
1996 Klein PS, Melton DA. A molecular mechanism for the effect of lithium on development. Proceedings of the National Academy of Sciences of the United States of America. 93: 8455-9. PMID 8710892 DOI: 10.1073/pnas.93.16.8455  0.321
1996 Graff JM, Bansal A, Melton DA. Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily. Cell. 85: 479-87. PMID 8653784 DOI: 10.1016/S0092-8674(00)81249-0  0.342
1996 Dohrmann CE, Kessler DS, Melton DA. Induction of axial mesoderm by zDVR-1, the zebrafish orthologue of Xenopus Vg1. Developmental Biology. 175: 108-17. PMID 8608857 DOI: 10.1006/dbio.1996.0099  0.304
1995 Klein PS, Melton DA. Translational control of activin in Xenopus laevis embryos. Developmental Genetics. 17: 55-64. PMID 7554495 DOI: 10.1002/dvg.1020170107  0.351
1995 Kelly OG, Melton DA. Induction and patterning of the vertebrate nervous system. Trends in Genetics : Tig. 11: 273-8. PMID 7482777 DOI: 10.1016/S0168-9525(00)89074-5  0.319
1994 Hemmati-Brivanlou A, Kelly OG, Melton DA. Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. Cell. 77: 283-95. PMID 8168135 DOI: 10.1016/0092-8674(94)90320-4  0.322
1994 Hemmati-Brivanlou A, Melton DA. Inhibition of activin receptor signaling promotes neuralization in Xenopus. Cell. 77: 273-81. PMID 8168134 DOI: 10.1016/0092-8674(94)90319-0  0.382
1994 Klein PS, Melton DA. Hormonal regulation of embryogenesis: the formation of mesoderm in Xenopus laevis. Endocrine Reviews. 15: 326-41. PMID 8076585 DOI: 10.1210/edrv-15-3-326  0.398
1994 Klein PS, Melton DA. Induction of mesoderm in Xenopus laevis embryos by translation initiation factor 4E. Science (New York, N.Y.). 265: 803-6. PMID 8047887 DOI: 10.1126/Science.8047887  0.334
1994 Wilson PA, Melton DA. Mesodermal patterning by an inducer gradient depends on secondary cell-cell communication. Current Biology : Cb. 4: 676-86. PMID 7953553 DOI: 10.1016/S0960-9822(00)00152-4  0.427
1994 Kessler DS, Melton DA. Vertebrate embryonic induction: mesodermal and neural patterning. Science (New York, N.Y.). 266: 596-604. PMID 7939714 DOI: 10.1126/Science.7939714  0.364
1993 Dohrmann CE, Hemmati-Brivanlou A, Thomsen GH, Fields A, Woolf TM, Melton DA. Expression of activin mRNA during early development in Xenopus laevis. Developmental Biology. 157: 474-83. PMID 8500654 DOI: 10.1006/Dbio.1993.1150  0.701
1993 Thomsen GH, Melton DA. Processed Vg1 protein is an axial mesoderm inducer in Xenopus. Cell. 74: 433-41. PMID 8348610 DOI: 10.1016/0092-8674(93)80045-G  0.707
1993 Steinbeisser H, De Robertis EM, Ku M, Kessler DS, Melton DA. Xenopus axis formation: induction of goosecoid by injected Xwnt-8 and activin mRNAs. Development (Cambridge, England). 118: 499-507. PMID 7900991  0.496
1992 Whitman M, Melton DA. Involvement of p21ras in Xenopus mesoderm induction. Nature. 357: 252-4. PMID 1589022 DOI: 10.1038/357252A0  0.323
1992 Mowry KL, Melton DA. Vegetal messenger RNA localization directed by a 340-nt RNA sequence element in Xenopus oocytes. Science (New York, N.Y.). 255: 991-4. PMID 1546297 DOI: 10.1126/Science.1546297  0.686
1992 Sokol SY, Melton DA. Interaction of Wnt and activin in dorsal mesoderm induction in Xenopus. Developmental Biology. 154: 348-55. PMID 1426642 DOI: 10.1016/0012-1606(92)90073-P  0.413
1992 Hemmati-Brivanlou A, Wright DA, Melton DA. Embryonic expression and functional analysis of a Xenopus activin receptor. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 194: 1-11. PMID 1384808 DOI: 10.1002/aja.1001940102  0.312
1992 Hemmati-Brivanlou A, Melton DA. A truncated activin receptor inhibits mesoderm induction and formation of axial structures in Xenopus embryos. Nature. 359: 609-14. PMID 1328888 DOI: 10.1038/359609a0  0.337
1992 Jessell TM, Melton DA. Diffusible factors in vertebrate embryonic induction. Cell. 68: 257-70. PMID 1310256 DOI: 10.1016/0092-8674(92)90469-S  0.451
1991 Sokol S, Melton DA. Pre-existent pattern in Xenopus animal pole cells revealed by induction with activin. Nature. 351: 409-11. PMID 2034291 DOI: 10.1038/351409a0  0.394
1991 Gururajan R, Perry-O'Keefe H, Melton DA, Weeks DL. The Xenopus localized messenger RNA An3 may encode an ATP-dependent RNA helicase. Nature. 349: 717-9. PMID 1996140 DOI: 10.1038/349717A0  0.654
1991 Sokol S, Christian JL, Moon RT, Melton DA. Injected Wnt RNA induces a complete body axis in Xenopus embryos. Cell. 67: 741-52. PMID 1834344 DOI: 10.1016/0092-8674(91)90069-B  0.358
1991 O'Keefe HP, Melton DA, Ferreiro B, Kintner C. In situ hyridization. Methods in Cell Biology. 36: 443-63. PMID 1811146 DOI: 10.1016/S0091-679X(08)60291-5  0.648
1991 Vize PD, Melton DA, Hemmati-Brivanlou A, Harland RM. Assays for gene function in developing Xenopus embryos. Methods in Cell Biology. 36: 367-87. PMID 1811145 DOI: 10.1016/S0091-679X(08)60288-5  0.711
1991 Melton DA. Pattern formation during animal development. Science (New York, N.Y.). 252: 234-41. PMID 1672778 DOI: 10.1126/Science.1672778  0.312
1991 Altaba ARI, Choi T, Melton DA. Expression of the Xhox3 homeobox protein in Xenopus embryos: Blocking its early function suggests the requirement of Xhox3 for normal posterior development Development Growth and Differentiation. 33: 651-669. DOI: 10.1111/J.1440-169X.1991.00651.X  0.335
1990 Sokol S, Wong GG, Melton DA. A mouse macrophage factor induces head structures and organizes a body axis in Xenopus. Science (New York, N.Y.). 249: 561-4. PMID 2382134 DOI: 10.1126/Science.2382134  0.362
1990 Mitrani E, Ziv T, Thomsen G, Shimoni Y, Melton DA, Bril A. Activin can induce the formation of axial structures and is expressed in the hypoblast of the chick. Cell. 63: 495-501. PMID 2225063 DOI: 10.1016/0092-8674(90)90446-L  0.665
1990 Thomsen G, Woolf T, Whitman M, Sokol S, Vaughan J, Vale W, Melton DA. Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures. Cell. 63: 485-93. PMID 2225062 DOI: 10.1016/0092-8674(90)90445-K  0.701
1990 Ruiz i Altaba A, Melton DA. Axial patterning and the establishment of polarity in the frog embryo. Trends in Genetics : Tig. 6: 57-64. PMID 2186530 DOI: 10.1016/0168-9525(90)90075-H  0.341
1989 Krieg PA, Varnum SM, Wormington WM, Melton DA. The mRNA encoding elongation factor 1-alpha (EF-1 alpha) is a major transcript at the midblastula transition in Xenopus. Developmental Biology. 133: 93-100. PMID 2707491 DOI: 10.1016/0012-1606(89)90300-X  0.526
1989 Whitman M, Melton DA. Induction of mesoderm by a viral oncogene in early Xenopus embryos. Science (New York, N.Y.). 244: 803-6. PMID 2658054 DOI: 10.1126/Science.2658054  0.378
1989 Ruiz i Altaba A, Melton DA. Interaction between peptide growth factors and homoeobox genes in the establishment of antero-posterior polarity in frog embryos. Nature. 341: 33-8. PMID 2570357 DOI: 10.1038/341033a0  0.333
1989 Ruiz i Altaba A, Melton DA. Involvement of the Xenopus homeobox gene Xhox3 in pattern formation along the anterior-posterior axis. Cell. 57: 317-26. PMID 2564813 DOI: 10.1016/0092-8674(89)90969-0  0.377
1989 Tannahill D, Melton DA. Localized synthesis of the Vg1 protein during early Xenopus development. Development (Cambridge, England). 106: 775-85. PMID 2562668  0.618
1988 Mercola M, Melton DA, Stiles CD. Platelet-derived growth factor A chain is maternally encoded in Xenopus embryos. Science (New York, N.Y.). 241: 1223-5. PMID 3413486 DOI: 10.1126/Science.3413486  0.313
1988 Harvey RP, Melton DA. Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos. Cell. 53: 687-97. PMID 2897242 DOI: 10.1016/0092-8674(88)90087-6  0.346
1987 Melton DA. Translocation of a localized maternal mRNA to the vegetal pole of Xenopus oocytes. Nature. 328: 80-2. PMID 3600777 DOI: 10.1038/328080a0  0.32
1987 Weeks DL, Melton DA. A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta. Cell. 51: 861-7. PMID 3479264 DOI: 10.1016/0092-8674(87)90109-7  0.641
1987 Krieg PA, Melton DA. An enhancer responsible for activating transcription at the midblastula transition in Xenopus development. Proceedings of the National Academy of Sciences of the United States of America. 84: 2331-5. PMID 3470796 DOI: 10.1073/Pnas.84.8.2331  0.609
1987 Weeks DL, Melton DA. A maternal mRNA localized to the animal pole of Xenopus eggs encodes a subunit of mitochondrial ATPase. Proceedings of the National Academy of Sciences of the United States of America. 84: 2798-802. PMID 2953029 DOI: 10.1073/Pnas.84.9.2798  0.625
1987 Krieg PA, Melton DA. In vitro RNA synthesis with SP6 RNA polymerase. Methods in Enzymology. 155: 397-415. PMID 2828872 DOI: 10.1016/0076-6879(87)55027-3  0.576
1987 Ruiz i Altaba A, Perry-O'Keefe H, Melton DA. Xfin: an embryonic gene encoding a multifingered protein in Xenopus. The Embo Journal. 6: 3065-70. PMID 2826129 DOI: 10.1002/J.1460-2075.1987.Tb02613.X  0.333
1987 Kintner CR, Melton DA. Expression of Xenopus N-CAM RNA in ectoderm is an early response to neural induction. Development (Cambridge, England). 99: 311-25. PMID 2443340  0.564
1986 Harvey RP, Tabin CJ, Melton DA. Embryonic expression and nuclear localization of Xenopus homeobox (Xhox) gene products. The Embo Journal. 5: 1237-44. PMID 3015593 DOI: 10.1002/J.1460-2075.1986.Tb04352.X  0.57
1985 Krieg PA, Melton DA. Developmental regulation of a gastrula-specific gene injected into fertilized Xenopus eggs. The Embo Journal. 4: 3463-71. PMID 4092685 DOI: 10.1002/J.1460-2075.1985.Tb04105.X  0.621
1985 Weeks DL, Rebagliati MR, Harvey RP, Melton DA. Localized maternal mRNAs in Xenopus laevis eggs. Cold Spring Harbor Symposia On Quantitative Biology. 50: 21-30. PMID 3006987 DOI: 10.1101/Sqb.1985.050.01.005  0.615
1985 Rebagliati MR, Weeks DL, Harvey RP, Melton DA. Identification and cloning of localized maternal RNAs from Xenopus eggs. Cell. 42: 769-77. PMID 2414011 DOI: 10.1016/0092-8674(85)90273-9  0.639
1984 Krieg PA, Melton DA. Formation of the 3' end of histone mRNA by post-transcriptional processing. Nature. 308: 203-6. PMID 6700722 DOI: 10.1038/308203a0  0.595
1984 Krieg PA, Melton DA. Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs. Nucleic Acids Research. 12: 7057-70. PMID 6207484 DOI: 10.1093/nar/12.18.7057  0.594
1984 Melton DA, Krieg PA, Rebagliati MR, Maniatis T, Zinn K, Green MR. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Research. 12: 7035-56. PMID 6091052 DOI: 10.1093/Nar/12.18.7035  0.578
1983 Perry HE, Melton DA. A rapid increase in acetylcholinesterase mRNA during ascidian embryogenesis as demonstrated by microinjection into Xenopus laevis oocytes. Cell Differentiation. 13: 233-8. PMID 6141851 DOI: 10.1016/0045-6039(83)90094-5  0.366
1982 Ciampi MS, Melton DA, Cortese R. Site-directed mutagenesis of a tRNA gene: base alterations in the coding region affect transcription. Proceedings of the National Academy of Sciences of the United States of America. 79: 1388-92. PMID 6951183 DOI: 10.1073/Pnas.79.5.1388  0.315
1981 Gurdon JB, Melton DA. Gene transfer in amphibian eggs and oocytes. Annual Review of Genetics. 15: 189-218. PMID 7039494 DOI: 10.1146/Annurev.Ge.15.120181.001201  0.484
1981 Cortese R, Harland R, Melton D. Transcription of tRNA genes in vivo: single-stranded compared to double-stranded templates. Proceedings of the National Academy of Sciences of the United States of America. 77: 4147-51. PMID 7001455 DOI: 10.1073/PNAS.77.7.4147  0.492
1981 Miller JR, Melton DA. A transcriptionally active pseudogene in xenopus laevis oocyte 5S DNA. Cell. 24: 829-35. PMID 6166389 DOI: 10.1016/0092-8674(81)90108-2  0.306
1980 Melton DA, Cortese R, de Robertis EM, Trendelenburg MF, Gurdon JB. Gene injection into amphibian oocytes. Results and Problems in Cell Differentiation. 11: 8-14. PMID 7444205 DOI: 10.1007/978-3-540-38267-6_2  0.645
1980 Melton DA, De Robertis EM, Cortese R. Order and intracellular location of the events involved in the maturation of a spliced tRNA. Nature. 284: 143-8. PMID 6987526 DOI: 10.1038/284143a0  0.524
1979 Melton DA, Cortese R. Transcription of cloned tRNA genes and the nuclear partitioning of a tRNA precursor. Cell. 18: 1165-72. PMID 391407 DOI: 10.1016/0092-8674(79)90229-0  0.305
1979 Gurdon JB, Melton DA, De Robertis EM. Genetics in an oocyte. Ciba Foundation Symposium. 63-80. PMID 289482 DOI: 10.1002/9780470720486.ch5  0.583
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