Kimberly A. Dowd, Ph.D. - Publications

Affiliations: 
2008 Johns Hopkins University, Baltimore, MD 
Area:
Immunology, Virology Biology

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Bollman B, Nunna N, Bahl K, Hsiao CJ, Bennett H, Butler S, Foreman B, Burgomaster KE, Aleshnick M, Kong WP, Fisher BE, Ruckwardt TJ, Morabito KM, Graham BS, Dowd KA, et al. An optimized messenger RNA vaccine candidate protects non-human primates from Zika virus infection. Npj Vaccines. 8: 58. PMID 37080988 DOI: 10.1038/s41541-023-00656-4  0.32
2023 Reynoso GV, Gordon DN, Kalia A, Aguilar CC, Malo CS, Aleshnick M, Dowd KA, Cherry CR, Shannon JP, Vrba SM, Holmes AC, Alippe Y, Maciejewski S, Asano K, Diamond MS, et al. Zika virus spreads through infection of lymph node-resident macrophages. Cell Reports. 42: 112126. PMID 36795561 DOI: 10.1016/j.celrep.2023.112126  0.363
2022 Georgiev GI, Malonis RJ, Wirchnianski AS, Wessel AW, Jung HS, Cahill SM, Nyakatura EK, Vergnolle O, Dowd KA, Cowburn D, Pierson TC, Diamond MS, Lai JR. Resurfaced ZIKV EDIII nanoparticle immunogens elicit neutralizing and protective responses in vivo. Cell Chemical Biology. PMID 35231399 DOI: 10.1016/j.chembiol.2022.02.004  0.419
2021 Chen RE, Smith BK, Errico JM, Gordon DN, Winkler ES, VanBlargan LA, Desai C, Handley SA, Dowd KA, Amaro-Carambot E, Cardosa MJ, Sariol CA, Kallas EG, Sékaly RP, Vasilakis N, et al. Implications of a highly divergent dengue virus strain for cross-neutralization, protection, and vaccine immunity. Cell Host & Microbe. PMID 34610295 DOI: 10.1016/j.chom.2021.09.006  0.422
2021 VanBlargan LA, Milutinovic P, Goo L, DeMaso CR, Durbin AP, Whitehead SS, Pierson TC, Dowd KA. Dengue virus serotype 1 conformational dynamics confers virus strain-dependent patterns of neutralization by polyclonal sera. Journal of Virology. JVI0095621. PMID 34549976 DOI: 10.1128/JVI.00956-21  0.431
2021 Wessel AW, Dowd KA, Biering SB, Zhang P, Edeling MA, Nelson CA, Funk KE, DeMaso CR, Klein RS, Smith JL, Cao TM, Kuhn RJ, Fremont DH, Harris E, Pierson TC, et al. Levels of circulating NS1 impact West Nile virus spread to the brain. Journal of Virology. JVI0084421. PMID 34346770 DOI: 10.1128/JVI.00844-21  0.409
2021 Sanchez Vargas LA, Adam A, Masterson M, Smith M, Lyski ZL, Dowd KA, Pierson TC, Messer WB, Currier JR, Mathew A. Non-structural protein 1-specific antibodies directed against Zika Virus in humans mediate antibody-dependent cellular cytotoxicity. Immunology. PMID 34056709 DOI: 10.1111/imm.13380  0.457
2021 Burgomaster KE, Foreman BM, Aleshnick MA, Larman BC, Gordon DN, Maciejewski S, Morabito KM, Ledgerwood JE, Gaudinski MR, Chen GL, Mascola JR, Debbink K, Dowd KA, Graham BS, Pierson TC. Limited flavivirus cross-reactive antibody responses elicited by a ZIKV DNA vaccine candidate in humans. The Journal of Infectious Diseases. PMID 33961055 DOI: 10.1093/infdis/jiab185  0.344
2021 Fahad AS, Timm MR, Madan B, Burgomaster KE, Dowd KA, Normandin E, Gutiérrez-González MF, Pennington JM, De Souza MO, Henry AR, Laboune F, Wang L, Ambrozak DR, Gordon IJ, Douek DC, et al. Functional Profiling of Antibody Immune Repertoires in Convalescent Zika Virus Disease Patients. Frontiers in Immunology. 12: 615102. PMID 33732238 DOI: 10.3389/fimmu.2021.615102  0.389
2020 Vannella KM, Stein S, Connelly M, Swerczek J, Amaro-Carambot E, Coyle EM, Babyak A, Winkler CW, Saturday G, Gai ND, Hammoud DA, Dowd KA, Valencia LP, Ramos-Benitez MJ, Kindrachuk J, et al. Nonhuman primates exposed to Zika virus in utero are not protected against reinfection at 1 year postpartum. Science Translational Medicine. 12. PMID 33115950 DOI: 10.1126/scitranslmed.aaz4997  0.322
2020 Luisi K, Morabito KM, Burgomaster KE, Sharma M, Kong WP, Foreman BM, Patel S, Fisher B, Aleshnick MA, Laliberte J, Wallace M, Ruckwardt TJ, Gordon DN, Linton C, Ruggiero N, ... ... Dowd KA, et al. Development of a potent Zika virus vaccine using self-amplifying messenger RNA. Science Advances. 6: eaba5068. PMID 32821824 DOI: 10.1126/Sciadv.Aba5068  0.438
2020 Maciejewski S, Ruckwardt TJ, Morabito KM, Foreman BM, Burgomaster KE, Gordon DN, Pelc RS, DeMaso CR, Ko SY, Fisher BE, Yang ES, Nair D, Foulds KE, Todd JP, Kong WP, ... ... Dowd KA, et al. Distinct neutralizing antibody correlates of protection among related Zika virus vaccines identify a role for antibody quality. Science Translational Medicine. 12. PMID 32522807 DOI: 10.1126/Scitranslmed.Aaw9066  0.468
2020 Chen GL, Coates EE, Plummer SH, Carter CA, Berkowitz N, Conan-Cibotti M, Cox JH, Beck A, O'Callahan M, Andrews C, Gordon IJ, Larkin B, Lampley R, Kaltovich F, Gall J, ... ... Dowd KA, et al. Effect of a Chikungunya Virus-Like Particle Vaccine on Safety and Tolerability Outcomes: A Randomized Clinical Trial. Jama. 323: 1369-1377. PMID 32286643 DOI: 10.1001/Jama.2020.2477  0.428
2019 Van Rompay KKA, Keesler RI, Ardeshir A, Watanabe J, Usachenko J, Singapuri A, Cruzen C, Bliss-Moreau E, Murphy AM, Yee JL, Webster H, Dennis M, Singh T, Heimsath H, Lemos D, ... ... Dowd KA, et al. DNA vaccination before conception protects Zika virus-exposed pregnant macaques against prolonged viremia and improves fetal outcomes. Science Translational Medicine. 11. PMID 31852797 DOI: 10.1126/Scitranslmed.Aay2736  0.438
2019 Vinton CL, Magaziner SJ, Dowd KA, Robertson SJ, Amaro-Carambot E, Karmele EP, Ortiz AM, Starke CE, Mudd JC, Whitehead SS, Best SM, Pierson TC, Hickman HD, Brenchley JM. Simian Immunodeficiency Virus Infection of Rhesus Macaques Results in Delayed Zika Virus Clearance. Mbio. 10. PMID 31796542 DOI: 10.1128/Mbio.02790-19  0.498
2019 Zhao H, Xu L, Bombardi R, Nargi R, Deng Z, Errico JM, Nelson CA, Dowd KA, Pierson TC, Crowe JE, Diamond MS, Fremont DH. Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge. The Journal of Experimental Medicine. PMID 31757867 DOI: 10.1084/Jem.20191792  0.489
2019 Jagger BW, Dowd KA, Chen RE, Desai P, Foreman B, Burgomaster KE, Himansu S, Kong WP, Graham BS, Pierson TC, Diamond MS. Protective Efficacy of Nucleic Acid Vaccines Against Transmission of Zika Virus During Pregnancy in Mice. The Journal of Infectious Diseases. PMID 31260518 DOI: 10.1093/Infdis/Jiz338  0.447
2019 Jagger BW, Dowd KA, Chen R, Desai P, Himansu S, Graham BS, Pierson TC, Diamond MS. 2904. Protective Efficacy of Nucleic Acid Vaccines Against Transmission of Zika Virus During Pregnancy in Mice Open Forum Infectious Diseases. 6: S84-S84. DOI: 10.1093/Ofid/Ofz359.182  0.469
2018 Goo L, Debbink K, Kose N, Sapparapu G, Doyle MP, Wessel AW, Richner JM, Burgomaster KE, Larman BC, Dowd KA, Diamond MS, Crowe JE, Pierson TC. A protective human monoclonal antibody targeting the West Nile virus E protein preferentially recognizes mature virions. Nature Microbiology. PMID 30455471 DOI: 10.1038/S41564-018-0283-7  0.503
2018 Dowd KA, Pierson TC. The Many Faces of a Dynamic Virion: Implications of Viral Breathing on Flavivirus Biology and Immunogenicity. Annual Review of Virology. 5: 185-207. PMID 30265634 DOI: 10.1146/Annurev-Virology-092917-043300  0.521
2018 Emanuel J, Callison J, Dowd KA, Pierson TC, Feldmann H, Marzi A. A VSV-based Zika virus vaccine protects mice from lethal challenge. Scientific Reports. 8: 11043. PMID 30038228 DOI: 10.1038/S41598-018-29401-X  0.463
2018 Frei JC, Wirchnianski AS, Govero J, Vergnolle O, Dowd KA, Pierson TC, Kielian M, Girvin ME, Diamond MS, Lai JR. Engineered Dengue Virus Domain III Proteins Elicit Cross-neutralizing Antibody Responses in Mice. Journal of Virology. PMID 29976679 DOI: 10.1128/Jvi.01023-18  0.552
2017 Gaudinski MR, Houser KV, Morabito KM, Hu Z, Yamshchikov G, Rothwell RS, Berkowitz N, Mendoza F, Saunders JG, Novik L, Hendel CS, Holman LA, Gordon IJ, Cox JH, Edupuganti S, ... ... Dowd KA, et al. Safety, tolerability, and immunogenicity of two Zika virus DNA vaccine candidates in healthy adults: randomised, open-label, phase 1 clinical trials. Lancet (London, England). PMID 29217376 DOI: 10.1016/S0140-6736(17)33105-7  0.473
2017 Richner JM, Jagger BW, Shan C, Fontes CR, Dowd KA, Cao B, Himansu S, Caine EA, Nunes BTD, Medeiros DBA, Muruato AE, Foreman BM, Luo H, Wang T, Barrett AD, et al. Vaccine Mediated Protection Against Zika Virus-Induced Congenital Disease. Cell. 170: 273-283.e12. PMID 28708997 DOI: 10.1016/J.Cell.2017.06.040  0.418
2017 Richner JM, Himansu S, Dowd KA, Butler SL, Salazar V, Fox JM, Julander JG, Tang WW, Shresta S, Pierson TC, Ciaramella G, Diamond MS. Modified mRNA Vaccines Protect against Zika Virus Infection. Cell. 169: 176. PMID 28340344 DOI: 10.1016/J.Cell.2017.03.016  0.499
2017 Richner JM, Himansu S, Dowd KA, Butler SL, Salazar V, Fox JM, Julander JG, Tang WW, Shresta S, Pierson TC, Ciaramella G, Diamond MS. Modified mRNA Vaccines Protect against Zika Virus Infection. Cell. PMID 28222903 DOI: 10.1016/J.Cell.2017.02.017  0.53
2017 Goo L, VanBlargan LA, Dowd KA, Diamond MS, Pierson TC. A single mutation in the envelope protein modulates flavivirus antigenicity, stability, and pathogenesis. Plos Pathogens. 13: e1006178. PMID 28207910 DOI: 10.1371/Journal.Ppat.1006178  0.465
2017 Pardi N, Hogan MJ, Pelc RS, Muramatsu H, Andersen H, DeMaso CR, Dowd KA, Sutherland LL, Scearce RM, Parks R, Wagner W, Granados A, Greenhouse J, Walker M, Willis E, et al. Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination. Nature. PMID 28151488 DOI: 10.1038/Nature21428  0.426
2016 Dowd KA, Ko SY, Morabito KM, Yang ES, Pelc RS, DeMaso CR, Castilho LR, Abbink P, Boyd M, Nityanandam R, Gordon DN, Gallagher JR, Chen X, Todd JP, Tsybovsky Y, et al. Rapid development of a DNA vaccine for Zika virus. Science (New York, N.Y.). PMID 27708058 DOI: 10.1126/Science.Aai9137  0.452
2016 Goo L, Dowd KA, Lin TY, Mascola JR, Graham BS, Ledgerwood JE, Pierson TC. A virus-like particle vaccine elicits broad neutralizing antibody responses in humans to all Chikungunya virus genotypes. The Journal of Infectious Diseases. PMID 27655868 DOI: 10.1093/Infdis/Jiw431  0.497
2016 Goo L, Dowd KA, Smith AR, Pelc RS, DeMaso CR, Pierson TC. Zika Virus Is Not Uniquely Stable at Physiological Temperatures Compared to Other Flaviviruses. Mbio. 7. PMID 27601578 DOI: 10.1128/Mbio.01396-16  0.45
2016 Dowd KA, DeMaso CR, Pelc RS, Speer SD, Smith AR, Goo L, Platt DJ, Mascola JR, Graham BS, Mulligan MJ, Diamond MS, Ledgerwood JE, Pierson TC. Broadly Neutralizing Activity of Zika Virus-Immune Sera Identifies a Single Viral Serotype. Cell Reports. PMID 27481466 DOI: 10.1016/J.Celrep.2016.07.049  0.522
2016 Zhao H, Fernandez E, Dowd KA, Speer SD, Platt DJ, Gorman MJ, Govero J, Nelson CA, Pierson TC, Diamond MS, Fremont DH. Structural Basis of Zika Virus-Specific Antibody Protection. Cell. PMID 27475895 DOI: 10.1016/J.Cell.2016.07.020  0.526
2016 Mukherjee S, Sirohi D, Dowd KA, Chen Z, Diamond MS, Kuhn RJ, Pierson TC. Enhancing dengue virus maturation using a stable furin over-expressing cell line. Virology. 497: 33-40. PMID 27420797 DOI: 10.1016/J.Virol.2016.06.022  0.45
2016 Zhang R, Miner JJ, Gorman MJ, Rausch K, Ramage H, White JP, Zuiani A, Zhang P, Fernandez E, Zhang Q, Dowd KA, Pierson TC, Cherry S, Diamond MS. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Nature. 535: 164-168. PMID 27383988 DOI: 10.1038/Nature18625  0.4
2015 Dowd KA, DeMaso CR, Pierson TC. Genotypic Differences in Dengue Virus Neutralization Are Explained by a Single Amino Acid Mutation That Modulates Virus Breathing. Mbio. 6: e01559-15. PMID 26530385 DOI: 10.1128/Mbio.01559-15  0.457
2015 VanBlargan LA, Davis KA, Dowd KA, Akey DL, Smith JL, Pierson TC. Context-Dependent Cleavage of the Capsid Protein by the West Nile Virus Protease Modulates the Efficiency of Virus Assembly. Journal of Virology. 89: 8632-42. PMID 26063422 DOI: 10.1128/Jvi.01253-15  0.422
2015 Kuhn RJ, Dowd KA, Beth Post C, Pierson TC. Shake, rattle, and roll: Impact of the dynamics of flavivirus particles on their interactions with the host. Virology. 479: 508-517. PMID 25835729 DOI: 10.1016/J.Virol.2015.03.025  0.346
2015 Bailey JR, Dowd KA, Snider AE, Osburn WO, Mehta SH, Kirk GD, Thomas DL, Ray SC. CD4+ T-Cell-Dependent Reduction in Hepatitis C Virus-Specific Neutralizing Antibody Responses After Coinfection With Human Immunodeficiency Virus. The Journal of Infectious Diseases. PMID 25754978 DOI: 10.1093/Infdis/Jiv139  0.665
2014 Chang LJ, Dowd KA, Mendoza FH, Saunders JG, Sitar S, Plummer SH, Yamshchikov G, Sarwar UN, Hu Z, Enama ME, Bailer RT, Koup RA, Schwartz RM, Akahata W, Nabel GJ, et al. Safety and tolerability of chikungunya virus-like particle vaccine in healthy adults: a phase 1 dose-escalation trial. Lancet. 384: 2046-52. PMID 25132507 DOI: 10.1016/S0140-6736(14)61185-5  0.401
2014 Dowd KA, Mukherjee S, Kuhn RJ, Pierson TC. Combined effects of the structural heterogeneity and dynamics of flaviviruses on antibody recognition. Journal of Virology. 88: 11726-37. PMID 25078693 DOI: 10.1128/Jvi.01140-14  0.468
2014 Edeling MA, Austin SK, Shrestha B, Dowd KA, Mukherjee S, Nelson CA, Johnson S, Mabila MN, Christian EA, Rucker J, Pierson TC, Diamond MS, Fremont DH. Potent dengue virus neutralization by a therapeutic antibody with low monovalent affinity requires bivalent engagement. Plos Pathogens. 10: e1004072. PMID 24743696 DOI: 10.1371/Journal.Ppat.1004072  0.564
2014 Mukherjee S, Dowd KA, Manhart CJ, Ledgerwood JE, Durbin AP, Whitehead SS, Pierson TC. Mechanism and significance of cell type-dependent neutralization of flaviviruses. Journal of Virology. 88: 7210-20. PMID 24741083 DOI: 10.1128/Jvi.03690-13  0.47
2014 Mukherjee S, Pierson TC, Dowd KA. Pseudo-infectious reporter virus particles for measuring antibody-mediated neutralization and enhancement of dengue virus infection. Methods in Molecular Biology (Clifton, N.J.). 1138: 75-97. PMID 24696332 DOI: 10.1007/978-1-4939-0348-1_6  0.551
2014 Austin SK, Dowd KA. B cell response and mechanisms of antibody protection to West Nile virus. Viruses. 6: 1015-36. PMID 24594676 DOI: 10.3390/V6031015  0.551
2013 VanBlargan LA, Mukherjee S, Dowd KA, Durbin AP, Whitehead SS, Pierson TC. The type-specific neutralizing antibody response elicited by a dengue vaccine candidate is focused on two amino acids of the envelope protein. Plos Pathogens. 9: e1003761. PMID 24348242 DOI: 10.1371/Journal.Ppat.1003761  0.492
2013 Lee PD, Mukherjee S, Edeling MA, Dowd KA, Austin SK, Manhart CJ, Diamond MS, Fremont DH, Pierson TC. The Fc region of an antibody impacts the neutralization of West Nile viruses in different maturation states. Journal of Virology. 87: 13729-40. PMID 24109224 DOI: 10.1128/Jvi.02340-13  0.45
2013 Pal P, Dowd KA, Brien JD, Edeling MA, Gorlatov S, Johnson S, Lee I, Akahata W, Nabel GJ, Richter MK, Smit JM, Fremont DH, Pierson TC, Heise MT, Diamond MS. Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus. Plos Pathogens. 9: e1003312. PMID 23637602 DOI: 10.1371/Journal.Ppat.1003312  0.482
2013 Obara CJ, Dowd KA, Ledgerwood JE, Pierson TC. Impact of viral attachment factor expression on antibody-mediated neutralization of flaviviruses. Virology. 437: 20-7. PMID 23312596 DOI: 10.1016/J.Virol.2012.11.016  0.412
2012 Austin SK, Dowd KA, Shrestha B, Nelson CA, Edeling MA, Johnson S, Pierson TC, Diamond MS, Fremont DH. Structural basis of differential neutralization of DENV-1 genotypes by an antibody that recognizes a cryptic epitope. Plos Pathogens. 8: e1002930. PMID 23055922 DOI: 10.1371/Journal.Ppat.1002930  0.513
2012 Shrestha B, Austin SK, Dowd KA, Prasad AN, Youn S, Pierson TC, Fremont DH, Ebel GD, Diamond MS. Complex phenotypes in mosquitoes and mice associated with neutralization escape of a Dengue virus type 1 monoclonal antibody. Virology. 427: 127-34. PMID 22406169 DOI: 10.1016/J.Virol.2012.02.010  0.495
2012 Lin TY, Dowd KA, Manhart CJ, Nelson S, Whitehead SS, Pierson TC. A novel approach for the rapid mutagenesis and directed evolution of the structural genes of west nile virus. Journal of Virology. 86: 3501-12. PMID 22258236 DOI: 10.1128/Jvi.06435-11  0.404
2011 Vogt MR, Dowd KA, Engle M, Tesh RB, Johnson S, Pierson TC, Diamond MS. Poorly neutralizing cross-reactive antibodies against the fusion loop of West Nile virus envelope protein protect in vivo via Fcgamma receptor and complement-dependent effector mechanisms. Journal of Virology. 85: 11567-80. PMID 21917960 DOI: 10.1128/Jvi.05859-11  0.503
2011 Mukherjee S, Lin TY, Dowd KA, Manhart CJ, Pierson TC. The infectivity of prM-containing partially mature West Nile virus does not require the activity of cellular furin-like proteases. Journal of Virology. 85: 12067-72. PMID 21880759 DOI: 10.1128/Jvi.05559-11  0.512
2011 Dowd KA, Jost CA, Durbin AP, Whitehead SS, Pierson TC. A dynamic landscape for antibody binding modulates antibody-mediated neutralization of West Nile virus. Plos Pathogens. 7: e1002111. PMID 21738473 DOI: 10.1371/Journal.Ppat.1002111  0.492
2011 Dowd KA, Pierson TC. Antibody-mediated neutralization of flaviviruses: a reductionist view. Virology. 411: 306-15. PMID 21255816 DOI: 10.1016/J.Virol.2010.12.020  0.56
2010 Sukupolvi-Petty S, Austin SK, Engle M, Brien JD, Dowd KA, Williams KL, Johnson S, Rico-Hesse R, Harris E, Pierson TC, Fremont DH, Diamond MS. Structure and function analysis of therapeutic monoclonal antibodies against dengue virus type 2. Journal of Virology. 84: 9227-39. PMID 20592088 DOI: 10.1128/Jvi.01087-10  0.494
2010 Fletcher NF, Yang JP, Farquhar MJ, Hu K, Davis C, He Q, Dowd K, Ray SC, Krieger SE, Neyts J, Baumert TF, Balfe P, McKeating JA, Wong-Staal F. Hepatitis C virus infection of neuroepithelioma cell lines. Gastroenterology. 139: 1365-74. PMID 20538002 DOI: 10.1053/J.Gastro.2010.06.008  0.666
2010 Liu L, Fisher BE, Dowd KA, Astemborski J, Cox AL, Ray SC. Acceleration of hepatitis C virus envelope evolution in humans is consistent with progressive humoral immune selection during the transition from acute to chronic infection Journal of Virology. 84: 5067-5077. PMID 20200239 DOI: 10.1128/Jvi.02265-09  0.655
2010 Osburn WO, Fisher BE, Dowd KA, Urban G, Liu L, Ray SC, Thomas DL, Cox AL. Spontaneous control of primary hepatitis C virus infection and immunity against persistent reinfection. Gastroenterology. 138: 315-24. PMID 19782080 DOI: 10.1053/J.Gastro.2009.09.017  0.675
2009 Dowd KA, Netski DM, Wang XH, Cox AL, Ray SC. Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus. Gastroenterology. 136: 2377-86. PMID 19303013 DOI: 10.1053/J.Gastro.2009.02.080  0.685
2008 Rutebemberwa A, Ray SC, Astemborski J, Levine J, Liu L, Dowd KA, Clute S, Wang C, Korman A, Sette A, Sidney J, Pardoll DM, Cox AL. High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection. Journal of Immunology (Baltimore, Md. : 1950). 181: 8215-25. PMID 19050238 DOI: 10.4049/Jimmunol.181.12.8215  0.657
2008 Dowd KA, Hershow RC, Yawetz S, Larussa P, Diaz C, Landesman SH, Paul ME, Read JS, Lu M, Thomas DL, Netski DM, Ray SC. Maternal neutralizing antibody and transmission of hepatitis C virus to infants. The Journal of Infectious Diseases. 198: 1651-5. PMID 18928374 DOI: 10.1086/593067  0.601
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