Darren H. Freed, Ph.D. - Publications

Affiliations: 
2004 University of Manitoba, Winnipeg, Manitoba, Canada 
Area:
Animal Physiology Biology

118 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Lin LQ, Hatami S, Coe JY, Colen TM, Sergi C, Thompson R, Di Martino ES, Herzog W, Abu Sara Z, Freed DH, Khoo NS. A Novel Right Ventricular Volume and Pressure Loaded Piglet Heart Model for the Study of Tricuspid Valve Function. Journal of Visualized Experiments : Jove. PMID 32804160 DOI: 10.3791/61251  0.346
2020 Hatami S, White CW, Qi X, Buchko M, Ondrus M, Kinnear A, Himmat S, Sergi C, Nagendran J, Freed DH. Immunity and Stress Responses Are Induced During Ex Situ Heart Perfusion. Circulation. Heart Failure. CIRCHEARTFAILURE1190. PMID 32498623 DOI: 10.1161/Circheartfailure.119.006552  0.369
2020 Kang JJ, Bozso SJ, Boe D, Nagendran J, Moon MC, Freed DH, Nagendran J. Resveratrol Significantly Attenuates Cell Mediated Immune Rejection against Xenogenic Bovine Pericardium. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 39: S469-S470. PMID 32465829 DOI: 10.1016/J.Healun.2020.01.331  0.314
2020 Qi X, Hatami S, Bozso SJ, Buchko MT, Himmat S, Lautner L, Wang X, White CW, Nagendran J, Freed DH. The Impact of Whole Blood versus Dilute Whole Blood on Coronary Vascular Tone during Ex Situ Heart Perfusion. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 39: S351. PMID 32465491 DOI: 10.1016/J.Healun.2020.01.409  0.341
2020 Hatami S, Qi X, White CW, Buchko M, Bozsu S, Himmat S, Nagendran J, Freed DH. Preservation and Recovery of Myocardial Function during Normothermic Ex Situ Heart Perfusion: Does the Position of the Heart during Perfusion Matter? The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 39: S145-S146. PMID 32464906 DOI: 10.1016/J.Healun.2020.01.1070  0.423
2020 Bates A, Buchholz H, Freed D, MacArthur R, PiDBorochynski T, Conway J. Bivalirudin Experience in a Heterogeneous Ventricular Assist Device Population. Asaio Journal (American Society For Artificial Internal Organs : 1992). 66: 677-682. PMID 31567418 DOI: 10.1097/Mat.0000000000001062  0.307
2019 Bozso SJ, Kang JJH, Al-Adra D, Hong Y, Moon MC, Freed DH, Nagendran J, Nagendran J. Outcomes Following Bioprosthetic Valve Replacement in Prior Non-Cardiac Transplant Recipients. Clinical Transplantation. e13720. PMID 31556148 DOI: 10.1111/Ctr.13720  0.327
2019 Niederberger P, Farine E, Raillard M, Dornbierer M, Freed DH, Large SR, Chew HC, MacDonald PS, Messer SJ, White CW, Carrel TP, Tevaearai Stahel HT, Longnus SL. Heart Transplantation With Donation After Circulatory Death. Circulation. Heart Failure. 12: e005517. PMID 30998395 DOI: 10.1161/Circheartfailure.118.005517  0.387
2019 Hatami S, White CW, Shan S, Haromy A, Qi X, Ondrus M, Kinnear A, Himmat S, Michelakis E, Nagendran J, Freed DH. Myocardial functional decline during prolonged ex situ heart perfusion. The Annals of Thoracic Surgery. PMID 30872100 DOI: 10.1016/J.Athoracsur.2019.01.076  0.437
2019 Lucchinetti E, Lou PH, Hatami S, Qi X, Clanachan AS, Freed DH, Zaugg M. Enhanced myocardial protection in cardiac donation after circulatory death using Intralipid postconditioning in a porcine model. Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie. PMID 30790198 DOI: 10.1007/S12630-019-01322-X  0.41
2019 Hatami S, White CW, Ondrus M, Qi X, Buchko M, Himmat S, Lin L, Cameron K, Nobes D, Chung HJ, Nagendran J, Freed DH. Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism. Journal of Visualized Experiments : Jove. PMID 30688296 DOI: 10.3791/58430  0.429
2019 Bozso SJ, Kang J, Adam B, Moon MC, Freed DH, Nagendran J, Nagendran J. Abstract 700: Recellularization of Acellular Xenogenic Scaffold With Autologous Human Mesenchymal Stem Cells Rescues the Xenoreactive Immune Response Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.700  0.327
2019 Hatami S, White C, Qi X, Buchko M, Himmat S, Aboelnazar N, Nagendran J, Freed D. Metabolic Alterations in Myocardial Metabolism during Ex Situ Heart Perfusion The Journal of Heart and Lung Transplantation. 38: S237. DOI: 10.1016/J.Healun.2019.01.584  0.354
2019 Rotich S, Herbers N, Hatami S, Mengel M, Nagendran J, Freed D, Adam B. Gene Expression in Ex Vivo Perfused Porcine Hearts: Identification of a Molecular Injury-Repair Response The Journal of Heart and Lung Transplantation. 38: S183-S184. DOI: 10.1016/J.Healun.2019.01.443  0.386
2019 Qi X, Hatami S, Tkachuk B, Buchko M, Bozso S, He D, Himmat S, White C, Nagendran J, Freed D. The Evaluation of Coronary Artery Function during Normothermic Ex Situ Heart Perfusion The Journal of Heart and Lung Transplantation. 38: S75. DOI: 10.1016/J.Healun.2019.01.169  0.325
2019 Hatami S, Qi X, White C, Buchko M, Bozso S, Himmat S, Nagendran J, Freed D. OXIDATIVE STRESS AND RELATED RESPONSES ARE INDUCED DURING EX-SITU HEART PERFUSION AND MAY CONTRIBUTE TO THE FUNCTIONAL DECLINE OF THE EX-SITU-PERFUSED HEART Canadian Journal of Cardiology. 35: S106. DOI: 10.1016/J.Cjca.2019.07.499  0.375
2019 Hatami S, Freed DH. Machine Perfusion of Donor Heart: State of the Art Current Transplantation Reports. 6: 242-250. DOI: 10.1007/S40472-019-00251-4  0.352
2018 Jana S, Zhang H, Lopaschuk GD, Freed DH, Sergi C, Kantor PF, Oudit GY, Kassiri Z. Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts. Journal of the American Heart Association. 7: e010427. PMID 30371322 DOI: 10.1161/Jaha.118.010427  0.357
2018 Miskew Nichols B, Nikhanj A, Wang F, Freed DH, Oudit GY. Advanced Dilated Cardiomyopathy in a Patient With Hutterite Limb-Girdle Muscular Dystrophy: Use of a Left Ventricular Assist Device. Circulation. Heart Failure. 11: e004960. PMID 29626101 DOI: 10.1161/Circheartfailure.118.004960  0.401
2018 White CW, Messer SJ, Large SR, Conway J, Kim DH, Kutsogiannis DJ, Nagendran J, Freed DH. Transplantation of Hearts Donated after Circulatory Death. Frontiers in Cardiovascular Medicine. 5: 8. PMID 29487855 DOI: 10.3389/Fcvm.2018.00008  0.375
2018 Sandha JK, White CW, Müller A, Avery E, Thliveris J, Dixon IMC, Arora RC, Tian G, Hryshko LV, Nagendran J, Freed DH. Steroids Limit Myocardial Edema During Ex Vivo Perfusion Of Hearts Donated After Circulatory Death. The Annals of Thoracic Surgery. PMID 29382512 DOI: 10.1016/J.Athoracsur.2018.01.004  0.423
2018 Jana S, Zhang H, Freed D, Lopaschuk G, Kantor P, Oudit G, Kassiri Z. Remodeling of myocardial extracellular matrix and proteoglycans varies in pediatric versus adult patients with dilated cardiomyopathy Journal of Molecular and Cellular Cardiology. 124: 115. DOI: 10.1016/J.Yjmcc.2018.07.096  0.309
2018 Qi X, Hatami S, White C, Himmat S, Aboelnazer N, Ondrus M, Wu Y, Kinnear A, Nagendran J, Freed D. Inflammation and Innate Immune Activation During Ex Vivo Heart Perfusion The Journal of Heart and Lung Transplantation. 37: S220. DOI: 10.1016/J.Healun.2018.01.543  0.323
2017 Wang J, Xiang B, Deng JX, Lin HY, Freed DH, Arora RC, Tian GH. Hypoxia enhances the therapeutic potential of superparamagnetic iron oxide-labeled adipose-derived stem cells for myocardial infarction. Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban. 37: 516-522. PMID 28786062 DOI: 10.1007/S11596-017-1766-0  0.359
2017 Vasanthan V, Garg M, Maruyama M, Michelakis E, Freed DH, Nagendran J. Extended Bridge to Heart and Lung Transplantation Using Pumpless Extracorporeal Lung Assist. The Canadian Journal of Cardiology. PMID 28579162 DOI: 10.1016/J.Cjca.2017.03.014  0.345
2017 Wang J, Xiang B, Deng J, Lin HY, Freed DH, Arora RC, Tian G. Preservation of Myocardial Perfusion and Function by Keeping Hypertrophied Heart Empty and Beating for Valve Surgery: An In Vivo MR Study of Pig Hearts. Biomed Research International. 2017: 4107587. PMID 28409155 DOI: 10.1155/2017/4107587  0.439
2016 Messer SJ, Axell RG, Colah S, White PA, Ryan M, Page AA, Parizkova B, Valchanov K, White CW, Freed DH, Ashley E, Dunning J, Goddard M, Parameshwar J, Watson CJ, et al. Functional assessment and transplantation of the donor heart after circulatory death. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 35: 1443-1452. PMID 27916176 DOI: 10.1016/J.Healun.2016.07.004  0.373
2016 White C, Ambrose E, Müller A, Hatami S, Li Y, Le H, Thliveris J, Arora R, Lee T, Dixon I, Tian G, Nagendran J, Hryshko L, Freed D. Impact of Reperfusion Calcium and pH on the Resuscitation of Hearts Donated After Circulatory Death. The Annals of Thoracic Surgery. PMID 27526656 DOI: 10.1016/J.Athoracsur.2016.05.084  0.362
2016 Wang J, Xiang B, Deng J, Lin HY, Zheng D, Freed DH, Arora RC, Tian G. Externally Applied Static Magnetic Field Enhances Cardiac Retention and Functional Benefit of Magnetically Iron-Labeled Adipose-Derived Stem Cells in Infarcted Hearts. Stem Cells Translational Medicine. PMID 27400797 DOI: 10.5966/Sctm.2015-0220  0.399
2016 Sakamuri SS, Takawale A, Basu R, Fedak PW, Freed D, Sergi C, Oudit GY, Kassiri Z. Differential impact of mechanical unloading on structural and nonstructural components of the extracellular matrix in advanced human heart failure. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 26963743 DOI: 10.1016/J.Trsl.2016.02.006  0.371
2016 Lee TW, Kowalski S, Falk K, Maguire D, Freed DH, HayGlass KT. High Spinal Anesthesia Enhances Anti-Inflammatory Responses in Patients Undergoing Coronary Artery Bypass Graft Surgery and Aortic Valve Replacement: Randomized Pilot Study. Plos One. 11: e0149942. PMID 26930568 DOI: 10.1371/Journal.Pone.0149942  0.323
2016 Nagendran J, Moore MD, Norris CM, Khani-Hanjani A, Graham MM, Freed DH, Nagendran J. The varying effects of obesity and morbid obesity on outcomes following cardiac transplantation. International Journal of Obesity (2005). PMID 26853917 DOI: 10.1038/Ijo.2016.20  0.331
2016 White CW, Ambrose E, Müller A, Li Y, Le H, Thliveris J, Arora RC, Lee TW, Dixon IM, Tian G, Nagendran J, Hryshko LV, Freed DH. Avoidance of Profound Hypothermia During Initial Reperfusion Improves the Functional Recovery of Hearts Donated After Circulatory Death. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 26780159 DOI: 10.1111/Ajt.13574  0.319
2016 White C, Shan S, Hatami S, Gurtu V, Kinnaird A, Matsumura N, Aboelnazar N, Dyck J, Lopaschuk G, Michelakis E, Nagendran J, Freed D. Impact of Myocardial Load on the Preservation of Donor Heart Function during Ex Vivo Perfusion The Journal of Heart and Lung Transplantation. 35: S186. DOI: 10.1016/J.Healun.2016.01.518  0.385
2016 Sandha J, White C, Müller A, Ambrose E, Thliveris J, Dixon I, Arora R, Tian G, Hryshko L, Nagendran J, Freed D. Impact of Methylprednisolone on the Development of Myocardial Edema in Hearts Donated After Circulatory Death During Ex Vivo Perfusion The Journal of Heart and Lung Transplantation. 35: S142. DOI: 10.1016/J.Healun.2016.01.392  0.418
2016 White C, Nagendran J, Freed D. ASSESSMENT OF PRELOAD-RECRUITABLE STROKE WORK DURING BIVENTRICULAR EX VIVO HEART PERFUSION: A NOVEL APPROACH ELIMINATING THE PRESSURE-VOLUME LOOP CATHETER Canadian Journal of Cardiology. 32: S173-S174. DOI: 10.1016/J.Cjca.2016.07.270  0.31
2016 Müller A, Wu Y, Haromy A, Freed D. DECELLULARIZED VENTRICULAR MATRIX AS A MODEL FOR STUDYING HUMAN MESENCHYMAL CELL PHENOTYPES Canadian Journal of Cardiology. 32: S83-S84. DOI: 10.1016/J.Cjca.2016.07.110  0.307
2015 White CW, Lillico R, Sandha J, Hasanally D, Wang F, Ambrose E, Müller A, Rachid O, Li Y, Xiang B, Le H, Messer S, Ali A, Large SR, Lee TW, ... ... Freed DH, et al. Physiologic Changes in the Heart Following Cessation of Mechanical Ventilation in a Porcine Model of Donation After Circulatory Death: Implications for Cardiac Transplantation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 26663659 DOI: 10.1111/Ajt.13543  0.406
2015 White CW, Ambrose E, Müller A, Li Y, Le H, Hiebert B, Arora R, Lee TW, Dixon I, Tian G, Nagendran J, Hryshko L, Freed D. Assessment of donor heart viability during ex vivo heart perfusion. Canadian Journal of Physiology and Pharmacology. 93: 893-901. PMID 26317524 DOI: 10.1139/Cjpp-2014-0474  0.378
2015 Bordun KA, Premecz S, daSilva M, Mandal S, Goyal V, Glavinovic T, Cheung M, Cheung D, White CW, Chaudhary R, Freed DH, Villarraga HR, Herrmann J, Kohli M, Ravandi A, et al. The utility of cardiac biomarkers and echocardiography for the early detection of Bevacizumab and Sunitinib mediated cardiotoxicity. American Journal of Physiology. Heart and Circulatory Physiology. ajpheart.00172.2015. PMID 26092985 DOI: 10.1152/Ajpheart.00172.2015  0.37
2015 Freed DH, White CW. Donor heart preservation: straight up, or on the rocks? Lancet (London, England). 385: 2552-4. PMID 25888084 DOI: 10.1016/S0140-6736(15)60614-6  0.364
2015 Wang J, Xiang B, Lin HY, Liu H, Freed D, Arora RC, Tian G. Differential MR delayed enhancement patterns of chronic myocardial infarction between extracellular and intravascular contrast media. Plos One. 10: e0121326. PMID 25816056 DOI: 10.1371/Journal.Pone.0121326  0.31
2015 Ghavami S, Cunnington RH, Gupta S, Yeganeh B, Filomeno KL, Freed DH, Chen S, Klonisch T, Halayko AJ, Ambrose E, Singal R, Dixon IM. Autophagy is a regulator of TGF-β1-induced fibrogenesis in primary human atrial myofibroblasts. Cell Death & Disease. 6: e1696. PMID 25789971 DOI: 10.1038/Cddis.2015.36  0.73
2015 Chi C, Wang F, Xiang B, Deng J, Liu S, Lin HY, Natarajan K, Lin F, Freed DH, Arora RC, Liu H, Tian G. Adipose-Derived Stem Cells from both Visceral and Subcutaneous Fat Deposits Significantly Improve Contractile Function of Infarcted Rat Hearts. Cell Transplantation. PMID 25562327 DOI: 10.3727/096368914X685780  0.429
2015 Li Y, Müller AL, Ngo MA, Sran K, Bellan D, Arora RC, Kirshenbaum LA, Freed DH. Statins impair survival of primary human mesenchymal progenitor cells via mevalonate depletion, NF-κB signaling, and Bnip3. Journal of Cardiovascular Translational Research. 8: 96-105. PMID 25547946 DOI: 10.1007/S12265-014-9603-3  0.334
2015 White CW, Hasanally D, Mundt P, Li Y, Xiang B, Klein J, Müller A, Ambrose E, Ravandi A, Arora RC, Lee TW, Hryshko LV, Large S, Tian G, Freed DH. A whole blood-based perfusate provides superior preservation of myocardial function during ex vivo heart perfusion. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 34: 113-21. PMID 25447577 DOI: 10.1016/J.Healun.2014.09.021  0.401
2015 Ghavami S, Gupta S, Ambrose E, Hnatowich M, Freed DH, Dixon IM. Autophagy and heart disease: implications for cardiac ischemia-reperfusion damage. Current Molecular Medicine. 14: 616-29. PMID 24894175 DOI: 10.2174/1566524014666140603101520  0.415
2015 White C, Ambrose E, Müller A, Thliveris J, Arora R, Tian G, Nagendran J, Hryshko L, Freed D. Initial Reperfusion With a Hypocalcemic Cardioplegia Improves the Functional Recovery of DCD Hearts During Ex Vivo Heart Perfusion The Journal of Heart and Lung Transplantation. 34: S148-S149. DOI: 10.1016/J.Healun.2015.01.399  0.408
2015 White C, Shan S, Hatami S, Gurtu V, Kinnaird A, Matsumura N, Aboelnazar N, Dyck J, Lopaschuk G, Michelakis E, Freed D, Nagendran J. EX VIVO PERFUSION IN A LOADED STATE IMPROVES THE PRESERVATION OF DONOR HEART FUNCTION Canadian Journal of Cardiology. 31: S202. DOI: 10.1016/J.Cjca.2015.07.426  0.343
2015 White C, Ambrose E, Müller A, Thliveris J, Arora R, Tian G, Nagendran J, Hryshko L, Freed D. Impact of Initial Acidic Reperfusion on the Functional Recovery of DCD Hearts During Ex Vivo Heart Perfusion The Journal of Heart and Lung Transplantation. 34: S269-S270. DOI: 10.1016/J.Cjca.2014.07.435  0.397
2014 Bashir J, Legare JF, Freed DH, Cheung A, Rao V, Toma M. Multicentre Canadian experience with the HeartWare ventricular assist device: concerns about adverse neurological outcomes. The Canadian Journal of Cardiology. 30: 1662-7. PMID 25475468 DOI: 10.1016/J.Cjca.2014.07.746  0.301
2014 Bednarczyk JM, White CW, Ducas RA, Golian M, Nepomuceno R, Hiebert B, Bueddefeld D, Manji RA, Singal RK, Hussain F, Freed DH. Resuscitative extracorporeal membrane oxygenation for in hospital cardiac arrest: a Canadian observational experience. Resuscitation. 85: 1713-9. PMID 25449345 DOI: 10.1016/J.Resuscitation.2014.09.026  0.329
2014 Golian M, Freed D, Jassal DS, Ravandi A. Successful cardiac resuscitation with extracorporeal membrane oxygenation in the setting of persistent ventricular fibrillation: a case report. Bmc Research Notes. 7: 782. PMID 25371096 DOI: 10.1186/1756-0500-7-782  0.368
2014 Menard CE, Durston M, Zherebitskaya E, Smith DR, Freed D, Glazner GW, Tian G, Fernyhough P, Arora RC. Temporal dystrophic remodeling within the intrinsic cardiac nervous system of the streptozotocin-induced diabetic rat model. Acta Neuropathologica Communications. 2: 60. PMID 24894521 DOI: 10.1186/2051-5960-2-60  0.329
2014 Santiago JJ, McNaughton LJ, Koleini N, Ma X, Bestvater B, Nickel BE, Fandrich RR, Wigle JT, Freed DH, Arora RC, Kardami E. High molecular weight fibroblast growth factor-2 in the human heart is a potential target for prevention of cardiac remodeling. Plos One. 9: e97281. PMID 24827991 DOI: 10.1371/Journal.Pone.0097281  0.343
2014 Wang J, Xiang B, Lin HY, Liu H, Freed D, Arora RC, Tian G. Pathological mechanism for delayed hyperenhancement of chronic scarred myocardium in contrast agent enhanced magnetic resonance imaging. Plos One. 9: e96463. PMID 24802515 DOI: 10.1371/Journal.Pone.0096463  0.342
2014 Cheung AW, White CW, Davis MK, Freed DH. Short-term mechanical circulatory support for recovery from acute right ventricular failure: clinical outcomes. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 33: 794-9. PMID 24726682 DOI: 10.1016/J.Healun.2014.02.028  0.308
2014 Kumar K, Singal R, Manji RA, Zarychanski R, Bell DD, Freed DH, Arora RC. The benefits of 24/7 in-house intensivist coverage for prolonged-stay cardiac surgery patients. The Journal of Thoracic and Cardiovascular Surgery. 148: 290-297.e6. PMID 24703332 DOI: 10.1016/J.Jtcvs.2014.02.074  0.301
2014 Ngo MA, Müller A, Li Y, Neumann S, Tian G, Dixon IM, Arora RC, Freed DH. Human mesenchymal stem cells express a myofibroblastic phenotype in vitro: comparison to human cardiac myofibroblasts. Molecular and Cellular Biochemistry. 392: 187-204. PMID 24691634 DOI: 10.1007/S11010-014-2030-6  0.377
2014 Ducas RA, White CW, Wassef AW, Farag A, Bhagirath KM, Freed DH, Tam JW. Functional mitral regurgitation: current understanding and approach to management. The Canadian Journal of Cardiology. 30: 173-80. PMID 24461918 DOI: 10.1016/J.Cjca.2013.11.022  0.326
2014 White C, Li Y, Ambrose E, Muller A, Hiebert B, Lee T, Arora R, Tian G, Nagendran J, Hryshko L, Freed D. Assessment of Myocardial Performance During Ex Vivo Heart Perfusion. Transplantation. 98: 370. DOI: 10.1097/00007890-201407151-01205  0.405
2014 White C, Ambrose E, Muller A, Le H, Thliveris J, Lee T, Arora R, Tian G, Nagendran J, Hryshko L, Freed D. Initial Reperfusion of DCD Hearts Under Hypothermic Conditions Impairs Myocardial Functional Recovery During Ex Vivo Heart Perfusion. Transplantation. 98: 369. DOI: 10.1097/00007890-201407151-01202  0.409
2014 Chao C, Xiang B, Deng J, Lin H, Natarajan K, Lin F, Liu H, Freed D, Arora R, Tian G. P589Mediastinal adipose stem cells improve contractile function of failing hearts Cardiovascular Research. 103: S106.1-S106. DOI: 10.1093/Cvr/Cvu098.19  0.373
2014 Chi C, Xiang B, Deng J, Lin H, Natarajan K, Lin F, Liu H, Freed D, Arora R, Tian G. 286Cardioprotective potential of subcutaneous and visceral adipose-derived stem cells Cardiovascular Research. 103: S51.3-S51. DOI: 10.1093/Cvr/Cvu086.3  0.391
2014 White C, Li Y, Müller A, Ambrose E, Thliveris J, Lee T, Arora R, Tian G, Nagendran J, Hryskho L, Freed D. Impact of Initial Reperfusion Temperature on the Functional Recovery of DCD Hearts The Journal of Heart and Lung Transplantation. 33: S109. DOI: 10.1016/J.Healun.2014.01.325  0.35
2014 White C, Li Y, Müller A, Ambrose E, Hiebert B, Lee T, Arora R, Tian G, Nagendran J, Hryskho L, Freed D. Assessment of Myocardial Performance During Ex Vivo Heart Perfusion The Journal of Heart and Lung Transplantation. 33: S119-S120. DOI: 10.1016/J.Healun.2014.01.039  0.405
2014 Luc J, Zhao J, Michelakis E, Freed D, Nagendran J. GENDER SPECIFIC INFLUENCES ON EFFECTOR T-CELL FUNCTION AND PROLIFERATION: 2-METHOXYESTRADIOL MODULATES CELLULAR REJECTION Canadian Journal of Cardiology. 30: S251. DOI: 10.1016/J.Cjca.2014.07.434  0.412
2014 White C, Li Y, Müller A, Ambrose E, Le H, Thliveris J, Lee T, Arora R, Tian G, Nagendran J, Hryskho L, Freed D. AVOIDANCE OF PROFOUND HYPOTHERMIA DURING INITIAL REPERFUSION IMPROVES THE FUNCTIONAL RECOVERY OF DCD HEARTS Canadian Journal of Cardiology. 30: S250-S251. DOI: 10.1016/J.Cjca.2014.07.433  0.417
2014 Bednarczyk J, Ducas R, White C, Golian M, Nepomuceno R, Bueddefeld D, Hiebert B, Manji R, Singal R, Hussain F, Freed D. EXTRACORPOREAL MEMBRANE OXYGENATION FACILITATES SURVIVAL IN REFRACTORY IN- HOSPITAL CARDIAC ARREST AND CARDIOGENIC SHOCK Canadian Journal of Cardiology. 30: S242-S243. DOI: 10.1016/J.Cjca.2014.07.414  0.328
2014 Khani-Hanjani A, Nagendran J, Moore M, Norris C, Mullen J, Kim D, Freed D, Nagendran J. IS RECIPIENT BMI A RISK FACTOR FOR ADVERSE LONG-TERM SURVIVAL POST-CARDIAC TRANSPLANTATION? Canadian Journal of Cardiology. 30: S230-S231. DOI: 10.1016/J.Cjca.2014.07.389  0.315
2013 Nayak JG, White CW, Nates W, Sharda R, Horne D, Kaler K, Lytwyn M, Grocott HP, Freed DH, McGregor T. Laparoscopic nephroureterectomy in a patient with a left ventricular assist device. Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada. 7: E640-4. PMID 24409214 DOI: 10.5489/Cuaj.400  0.356
2013 Elhami E, Dietz B, Xiang B, Deng J, Wang F, Chi C, Goertzen AL, Mzengeza S, Freed D, Arora RC, Tian G. Assessment of three techniques for delivering stem cells to the heart using PET and MR imaging. Ejnmmi Research. 3: 72. PMID 24165377 DOI: 10.1186/2191-219X-3-72  0.331
2013 White CW, Ali A, Hasanally D, Xiang B, Li Y, Mundt P, Lytwyn M, Colah S, Klein J, Ravandi A, Arora RC, Lee TW, Hryshko L, Large S, Tian G, ... Freed DH, et al. A cardioprotective preservation strategy employing ex vivo heart perfusion facilitates successful transplant of donor hearts after cardiocirculatory death. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 32: 734-43. PMID 23796155 DOI: 10.1016/J.Healun.2013.04.016  0.412
2013 Farid S, Page A, Jenkins D, Jones MT, Freed D, Nashef SA. FIASCO II failure to achieve a satisfactory cardiac outcome study: the elimination of system errors. Interactive Cardiovascular and Thoracic Surgery. 17: 116-9. PMID 23592726 DOI: 10.1093/Icvts/Ivt162  0.369
2013 Müller AL, Freed D, Dhalla NS. Activation of proteases and changes in Na+-K+-ATPase subunits in hearts subjected to ischemia-reperfusion Journal of Applied Physiology. 114: 351-360. PMID 23221958 DOI: 10.1152/Japplphysiol.01239.2012  0.304
2013 White CW, Chelvanathan A, Zieroth S, Cordova-Perez F, Menkis AH, Freed DH. Can long-term ventricular assist devices be safely implanted in low-volume, non-heart transplant centres? The Canadian Journal of Cardiology. 29: 983-9. PMID 23021745 DOI: 10.1016/J.Cjca.2012.07.012  0.327
2013 Cheung A, White C, Davis M, Freed D. Temporary Mechanical Circulatory Support for Acute Right Ventricular Failure The Journal of Heart and Lung Transplantation. 32: S177. DOI: 10.1016/J.Healun.2013.01.424  0.349
2013 White C, Xiang B, Mundt P, Arora R, Tian G, Freed D. Ex Vivo Heart Preservation: Impact of an Acellular Hemoglobin-Based Oxygen Carrier on Myocardial Function and Energy Metabolism The Journal of Heart and Lung Transplantation. 32: S95. DOI: 10.1016/J.Healun.2013.01.1004  0.308
2013 White C, Ali A, Hasanally D, Wang F, Xiang B, Mundt P, Large S, Ravandi A, Lee T, Arora R, Tian G, Freed D. Right Ventricular Distension in Donor Hearts Following Cardiocirculatory Death: Implications for Post-Transplant Function The Journal of Heart and Lung Transplantation. 32: S95. DOI: 10.1016/J.Healun.2013.01.1003  0.38
2013 White CW, Mundt P, Li Y, Hasanally D, Xiang B, Klein JR, Lee TW, Arora RC, Ravandi A, Tian G, Freed DH. A Donor Whole Blood-Based Perfusate Provides Superior Preservation of Myocardial Function During Ex Vivo Heart Perfusion Canadian Journal of Cardiology. 29. DOI: 10.1016/J.Cjca.2013.07.644  0.389
2013 Hasanally D, White C, Chaudhary R, Klein J, Freed D, Ravandi A. Increased Oxidized Phosphatidylcholines During Global Cardiac Ischemia Correlates to Reduced Cardiac Function: Implications as Potential Target for Ischemia Reperfusion Injury Canadian Journal of Cardiology. 29: S344. DOI: 10.1016/J.Cjca.2013.07.587  0.365
2013 Kumar K, Azordegan N, Durston M, Li Y, Fischer G, Moghadasian M, Manji R, Freed D, Jassal D, Arora R. HMG-COA Reductase Inhibitors Do not Attenuate the Inflammatory Response Associated With Glutaraldehyde-Fixed Bioprosthetic Heart Valve Conduits Canadian Journal of Cardiology. 29: S261. DOI: 10.1016/J.Cjca.2013.07.429  0.333
2013 Arenson B, Hiebert B, Grocott H, Freed D, Bell D, Arora R. Development of a Daily Delirium Risk Scorecard in the Post-Cardiac Surgery Patient Canadian Journal of Cardiology. 29: S208-S209. DOI: 10.1016/J.Cjca.2013.07.341  0.308
2013 Pereira M, Jung P, Tangri N, Hiebert B, Freed D, Arora R. The Impact of Frailty on Post-Operative Delirium in Patients Undergoing Cardiac Surgery Canadian Journal of Cardiology. 29: S206. DOI: 10.1016/J.Cjca.2013.07.337  0.311
2012 Ghavami S, Cunnington RH, Yeganeh B, Davies JJ, Rattan SG, Bathe K, Kavosh M, Los MJ, Freed DH, Klonisch T, Pierce GN, Halayko AJ, Dixon IM. Autophagy regulates trans fatty acid-mediated apoptosis in primary cardiac myofibroblasts. Biochimica Et Biophysica Acta. 1823: 2274-86. PMID 23026405 DOI: 10.1016/J.Bbamcr.2012.09.008  0.74
2012 Müller AL, Freed D, Hryshko L, Dhalla NS. Implications of protease activation in cardiac dysfunction and development of genetic cardiomyopathy in hamsters Canadian Journal of Physiology and Pharmacology. 90: 995-1004. PMID 22784245 DOI: 10.1139/Y2012-034  0.419
2012 Ghavami S, Yeganeh B, Stelmack GL, Kashani HH, Sharma P, Cunnington R, Rattan S, Bathe K, Klonisch T, Dixon IM, Freed DH, Halayko AJ. Apoptosis, autophagy and ER stress in mevalonate cascade inhibition-induced cell death of human atrial fibroblasts. Cell Death & Disease. 3: e330. PMID 22717585 DOI: 10.1038/Cddis.2012.61  0.729
2012 Colah S, Freed DH, Mundt P, Germscheid S, White P, Ali A, Tian G, Large S, Falter F. Ex vivo perfusion of the swine heart as a method for pre-transplant assessment. Perfusion. 27: 408-13. PMID 22695793 DOI: 10.1177/0267659112449035  0.398
2012 Almoustadi WA, Lee TW, Klein J, Kumar K, Arora RC, Tian G, Freed DH. The effect of total spinal anesthesia on cardiac function in a large animal model of brain death. Canadian Journal of Physiology and Pharmacology. 90: 1287-93. PMID 22646969 DOI: 10.1139/Y2012-026  0.339
2012 Singh RB, Hryshko L, Freed D, Dhalla NS. Activation of proteolytic enzymes and depression of the sarcolemmal Na+/K+-ATPase in ischemia-reperfused heart may be mediated through oxidative stress. Canadian Journal of Physiology and Pharmacology. 90: 249-60. PMID 22316244 DOI: 10.1139/Y11-128  0.338
2012 Ali AA, Freed D, Large S. The Donation after Circulatory Death Donor can be a Source of Organs for Cardiac Transplantation Journal of Clinical and Experimental Cardiology. 2013: 1-4. DOI: 10.4172/2155-9880.S9-007  0.403
2012 White CW, Ali A, Xiang B, Colah S, Mundt P, Arora RC, Lee TW, Tsui SS, Large SR, Tian G, Freed DH. Initial Reperfusion of Hearts from DCD Donors with Tepid Normokalemic Adenosine/Lidocaine Cardioplegia Is Associated with Less Myocardial Injury and Improved Cardiac Function Transplantation Journal. 94: 157. DOI: 10.1097/00007890-201211271-00292  0.414
2012 Cheung A, Leprince P, Freed D. FIRST CLINICAL EVALUATION OF A NOVEL PERCUTANEOUS RIGHT VENTRICULAR ASSIST DEVICE: THE IMPELLA RP Journal of the American College of Cardiology. 59: E872. DOI: 10.1016/S0735-1097(12)60873-0  0.358
2012 Ali A, White C, Xiang B, Colah S, Mundt P, Arora R, Lee T, Tsui S, Large S, Tian G, Freed D. 94 Ex Vivo Assessment of DCD Hearts with STEEN Solution Is Associated with Less Myocardial Edema and Improved Cardiac Function The Journal of Heart and Lung Transplantation. 31: S40-S41. DOI: 10.1016/J.Healun.2012.01.098  0.417
2012 White C, Ali A, Xiang B, Colah S, Mundt P, Arora R, Lee T, Large S, Tian G, Freed D. 206 A Normokalemic Non-depolarizing Cardioplegia Minimizes Myocardial Injury And Improves Cardiac Function In A Large Animal Model Of Donation After Cardio-circulatory Death Canadian Journal of Cardiology. 28: S169. DOI: 10.1016/J.Cjca.2012.07.203  0.366
2011 Ali AA, White P, Xiang B, Lin HY, Tsui SS, Ashley E, Lee TW, Klein JR, Kumar K, Arora RC, Large SR, Tian G, Freed DH. Hearts from DCD donors display acceptable biventricular function after heart transplantation in pigs. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 11: 1621-32. PMID 21749639 DOI: 10.1111/J.1600-6143.2011.03622.X  0.427
2011 Freed DH, Chilton L, Li Y, Dangerfield AL, Raizman JE, Rattan SG, Visen N, Hryshko LV, Dixon IMCD. Role of myosin light chain kinase in cardiotrophin-1-induced cardiac myofibroblast cell migration American Journal of Physiology - Heart and Circulatory Physiology. 301: H514-H522. PMID 21572008 DOI: 10.1152/Ajpheart.01041.2010  0.337
2011 Ali A, Xiang B, Colah S, Mundt P, Arora R, Large S, Tian G, Freed D. 590 Evaluation of Load-Independent Biventricular Contractility during Machine Perfusion of the Donor Heart The Journal of Heart and Lung Transplantation. 30: S198. DOI: 10.1016/J.Healun.2011.01.602  0.418
2011 Ali A, White P, Xiang B, Arora R, Lee T, Ashley E, Large S, Tian G, Freed D. 348 Hearts from DCD Donors Display Excellent Biventricular Function Following Transplantation The Journal of Heart and Lung Transplantation. 30: S120-S121. DOI: 10.1016/J.Healun.2011.01.355  0.35
2011 White CW, Chelvanathan A, Zieroth S, Freed DH. Abstract sessions by dateCanadian Cardiovascular Society (CCS) CCS397 oral heart failure clinical trials and outcomes695 Can long-term ventricular assist devices be safely implanted in low-volume non-heart transplant centers Canadian Journal of Cardiology. 27. DOI: 10.1016/J.Cjca.2011.07.579  0.365
2011 Stillwell C, Wang J, Deng J, Wang F, Xiang B, Poritsanos N, Freed D, Arora R, Tian G. 199 Adipose tissue: A potential source of multipotent stem cells for treatment of heart failure Canadian Journal of Cardiology. 27: S132. DOI: 10.1016/J.Cjca.2011.07.144  0.332
2010 Berman M, Ali A, Ashley E, Freed D, Clarke K, Tsui S, Parameshwar J, Large S. Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death? The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 29: 957-65. PMID 20627624 DOI: 10.1016/J.Healun.2010.04.008  0.408
2010 Santiago JJ, Dangerfield AL, Rattan SG, Bathe KL, Cunnington RH, Raizman JE, Bedosky KM, Freed DH, Kardami E, Dixon IMC. Cardiac fibroblast to myofibroblast differentiation in vivo and in vitro: Expression of focal adhesion components in neonatal and adult rat ventricular myofibroblasts Developmental Dynamics. 239: 1573-1584. PMID 20503355 DOI: 10.1002/Dvdy.22280  0.762
2010 Guirgis M, Kumar K, Menkis AH, Freed DH. Minimally invasive left-heart decompression during venoarterial extracorporeal membrane oxygenation: an alternative to a percutaneous approach. Interactive Cardiovascular and Thoracic Surgery. 10: 672-4. PMID 20139202 DOI: 10.1510/Icvts.2009.228346  0.355
2010 Ngo M, Cunnington RH, Rattan SG, Dixon IM, Arora RC, Freed DH. MESENCHYMAL STEM CELLS ADOPT A MYOFIBROBLASTIC PHENOTYPE IN CULTURE: IMPLICATIONS FOR CELLULAR CARDIOMYOPLASTY Transplantation Journal. 90: 1046. DOI: 10.1097/00007890-201007272-02058  0.715
2010 Almoustadi WA, Lee TW, Xiang B, Arora RC, Lin H, Tian G, Freed DH. TOTAL SPINAL BLOCKADE WITH INTRATHECAL BUPIVICAINE PRESERVES CARDIAC CONTRACTILITY IN A LARGE ANIMAL MODEL OF BRAINSTEM DEATH Transplantation Journal. 90: 262. DOI: 10.1097/00007890-201007272-00494  0.32
2010 Ali A, Xiang B, White P, Tsui S, Ashley E, Large S, Lee T, Arora R, Tian G, Freed D. 352: Cardiac Resuscitation Following Circulatory Arrest in the Organ Donor Is Associated with Excellent Functional and Metabolic Recovery: Implications for Clinical Heart Transplantation The Journal of Heart and Lung Transplantation. 29: S118. DOI: 10.1016/J.Healun.2009.11.366  0.395
2009 Ducas RA, Jassal DS, Kirkpatrick ID, Freed DH, Zieroth SR, Ducas J. Dynamic compression of the left main coronary artery by the left atrium. Journal of Thoracic Imaging. 24: 237-40. PMID 19704331 DOI: 10.1097/Rti.0B013E3181A4Bb2C  0.307
2009 Freed DH, Drain AJ, Kitcat J, Jones MT, Nashef SA. Death in low-risk cardiac surgery: the failure to achieve a satisfactory cardiac outcome (FIASCO) study. Interactive Cardiovascular and Thoracic Surgery. 9: 623-5. PMID 19602493 DOI: 10.1510/Icvts.2009.208371  0.351
2009 Wang L, Deng J, Tian W, Xiang B, Yang T, Li G, Wang J, Gruwel M, Kashour T, Rendell J, Glogowski M, Tomanek B, Freed D, Deslauriers R, Arora RC, et al. Adipose-derived stem cells are an effective cell candidate for treatment of heart failure: an MR imaging study of rat hearts. American Journal of Physiology. Heart and Circulatory Physiology. 297: H1020-31. PMID 19574490 DOI: 10.1152/Ajpheart.01082.2008  0.455
2009 Ducas RA, Jassal DS, Zieroth SR, Kirkpatrick ID, Freed DH. Left ventricular outflow tract obstruction by a bioprosthetic mitral valve: diagnosis by cardiac computed tomography. Journal of Thoracic Imaging. 24: 132-5. PMID 19465838 DOI: 10.1097/Rti.0B013E31819Ca79D  0.351
2008 Wang L, Deng J, Wang J, Xiang B, Yang T, Gruwel M, Kashour T, Tomanek B, Summer R, Freed D, Jassal DS, Dai G, Glogowski M, Deslauriers R, Arora RC, et al. Superparamagnetic iron oxide does not affect the viability and function of adipose-derived stem cells, and superparamagnetic iron oxide-enhanced magnetic resonance imaging identifies viable cells. Magnetic Resonance Imaging. 27: 108-19. PMID 18657922 DOI: 10.1016/J.Mri.2008.05.013  0.318
2007 Raizman JE, Komljenovic J, Chang R, Deng C, Bedosky KM, Rattan SG, Cunnington RH, Freed DH, Dixon IM. The participation of the Na+-Ca2+ exchanger in primary cardiac myofibroblast migration, contraction, and proliferation. Journal of Cellular Physiology. 213: 540-51. PMID 17541957 DOI: 10.1002/Jcp.21134  0.763
2006 Freed D, Dangerfield A, Raizman J, Rattan S, Visen N, Hryshko L, Giles W, Dixon I. A79. Role of calcium in cardiotrophin-1 induced cardiac myofibroblast cell migration Journal of Molecular and Cellular Cardiology. 40: 871. DOI: 10.1016/J.Yjmcc.2006.03.305  0.325
2005 Freed DH, Cunnington RH, Dangerfield AL, Sutton JS, Dixon IM. Emerging evidence for the role of cardiotrophin-1 in cardiac repair in the infarcted heart. Cardiovascular Research. 65: 782-92. PMID 15721858 DOI: 10.1016/J.Cardiores.2004.11.026  0.772
2003 Freed DH, Moon MC, Borowiec AM, Jones SC, Zahradka P, Dixon IM. Cardiotrophin-1: expression in experimental myocardial infarction and potential role in post-MI wound healing. Molecular and Cellular Biochemistry. 254: 247-56. PMID 14674704 DOI: 10.1023/A:1027332504861  0.4
2003 Freed DH, Borowiec AM, Angelovska T, Dixon IM. Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways. Cardiovascular Research. 60: 365-75. PMID 14613866 DOI: 10.1016/S0008-6363(03)00534-0  0.324
2002 Freed DH, Borowiec AM, Jones SC, Dixon IM. 10 Cardiotrophin-1 induces proliferation and activation of primary adult rat cardiac fibroblasts Journal of Molecular and Cellular Cardiology. 34: A41. DOI: 10.1016/S0022-2828(02)90218-X  0.343
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