| Year |
Citation |
Score |
| 2021 |
Weston WC, Hales KH, Hales DB. Flaxseed Increases Animal Lifespan and Reduces Ovarian Cancer Severity by Toxically Augmenting One-Carbon Metabolism. Molecules (Basel, Switzerland). 26. PMID 34577143 DOI: 10.3390/molecules26185674 |
0.343 |
|
| 2021 |
Pal P, Starkweather KN, Hales KH, Hales DB. A Review of Principal Studies on the Development and Treatment of Epithelial Ovarian Cancer in the Laying Hen Gallus gallus. Comparative Medicine. PMID 34325771 DOI: 10.30802/AALAS-CM-20-000116 |
0.808 |
|
| 2020 |
Pal P, Hales K, Hales DB. The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling. Oncotarget. 11: 3646-3659. PMID 33088425 DOI: 10.18632/oncotarget.27760 |
0.808 |
|
| 2020 |
Choi PW, So WW, Yang J, Liu S, Tong KK, Kwan KM, Kwok JS, Tsui SKW, Ng SK, Hales KH, Hales DB, Welch WR, Crum CP, Fong WP, Berkowitz RS, et al. MicroRNA-200 family governs ovarian inclusion cyst formation and mode of ovarian cancer spread. Oncogene. PMID 32214198 DOI: 10.1038/S41388-020-1264-X |
0.426 |
|
| 2020 |
Weston C, Young M, Hales K, Hales DB. Abstract B48: Ovarian cancer risk in laying hens is reduced by dietary polyunsaturated fatty acids: Implications for soluble E-cadherin, de novo lipogenesis, and mitochondrial metabolism Clinical Cancer Research. 26. DOI: 10.1158/1557-3265.Ovca19-B48 |
0.476 |
|
| 2020 |
Starkweather K, Hales K, Hales D. Abstract B45: Anti-inflammatory actions of DHA via inhibition of the NF-κB pathway Clinical Cancer Research. 26. DOI: 10.1158/1557-3265.Ovca19-B45 |
0.466 |
|
| 2020 |
Pal P, Hales K, Hales DB. Abstract B35: Dietary flaxseed supplementation in ovarian cancer: Elucidating the molecular actions of its biologically derived active compounds Clinical Cancer Research. 26. DOI: 10.1158/1557-3265.Ovca19-B35 |
0.588 |
|
| 2019 |
Pal P, Hales K, Petrik J, Hales DB. Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active compounds from flaxseed diet, in preventing ovarian cancer. Journal of Ovarian Research. 12: 49. PMID 31128594 DOI: 10.1186/S13048-019-0523-3 |
0.808 |
|
| 2019 |
Weston C, Hales D, Hales K. Ovarian Cancer Risk in Laying Hens Is Reduced by Dietary Polyunsaturated Fatty Acids: A Case for Redox Homeostasis and Reprogrammed Mitochondrial Metabolism in Ovarian Tumors (OR04-05-19) Current Developments in Nutrition. 3. DOI: 10.1093/cdn/nzz030.OR04-05-19 |
0.48 |
|
| 2017 |
Dikshit A, Hales K, Hales DB. Whole flaxseed diet alters estrogen metabolism to promote 2-methoxtestradiol-induced apoptosis in hen ovarian cancer. Journal of Nutritional Biochemistry. 42: 117-125. PMID 28178600 DOI: 10.1016/J.Jnutbio.2017.01.002 |
0.536 |
|
| 2016 |
Davis JE, Cain J, Small C, Hales DB. Therapeutic effect of flax-based diets on fatty liver in aged laying hens. Poultry Science. PMID 27143762 DOI: 10.3382/Ps/Pew160 |
0.343 |
|
| 2016 |
Dikshit A, Gao C, Small C, Hales K, Hales DB. Flaxseed and its components differentially affect estrogen targets in pre-neoplastic hen ovaries. The Journal of Steroid Biochemistry and Molecular Biology. PMID 26925929 DOI: 10.1016/J.Jsbmb.2016.02.028 |
0.475 |
|
| 2016 |
Eastwood SM, Gibson L, Hales DB. Abstract B74: Dietary reprogramming of the metabolome of the laying hen: Prevention and suppression of ovarian cancer Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-B74 |
0.547 |
|
| 2015 |
Dikshit A, Gomes Filho MA, Eilati E, McGee S, Small C, Gao C, Klug T, Hales DB. Flaxseed reduces the pro-carcinogenic micro-environment in the ovaries of normal hens by altering the PG and oestrogen pathways in a dose-dependent manner. The British Journal of Nutrition. 113: 1384-95. PMID 25850566 DOI: 10.1017/S000711451500029X |
0.769 |
|
| 2014 |
Hales KH, Speckman SC, Kurrey NK, Hales DB. Uncovering molecular events associated with the chemosuppressive effects of flaxseed: a microarray analysis of the laying hen model of ovarian cancer. Bmc Genomics. 15: 709. PMID 25150550 DOI: 10.1186/1471-2164-15-709 |
0.541 |
|
| 2014 |
Lengyel E, Burdette JE, Kenny HA, Matei D, Pilrose J, Haluska P, Nephew KP, Hales DB, Stack MS. Epithelial ovarian cancer experimental models. Oncogene. 33: 3619-33. PMID 23934194 DOI: 10.1038/Onc.2013.321 |
0.38 |
|
| 2013 |
Eilati E, Small CC, McGee SR, Kurrey NK, Hales DB. Anti-inflammatory effects of fish oil in ovaries of laying hens target prostaglandin pathways. Lipids in Health and Disease. 12: 152. PMID 24156238 DOI: 10.1186/1476-511X-12-152 |
0.808 |
|
| 2013 |
Eilati E, Hales K, Zhuge Y, Ansenberger Fricano K, Yu R, van Breemen RB, Hales DB. Flaxseed enriched diet-mediated reduction in ovarian cancer severity is correlated to the reduction of prostaglandin E(2) in laying hen ovaries. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 89: 179-87. PMID 23978451 DOI: 10.1016/J.Plefa.2013.08.001 |
0.827 |
|
| 2013 |
Eilati E, Bahr JM, Hales DB. Long term consumption of flaxseed enriched diet decreased ovarian cancer incidence and prostaglandin E₂in hens. Gynecologic Oncology. 130: 620-8. PMID 23707669 DOI: 10.1016/J.Ygyno.2013.05.018 |
0.825 |
|
| 2012 |
Eilati E, Pan L, Bahr JM, Hales DB. Age dependent increase in prostaglandin pathway coincides with onset of ovarian cancer in laying hens. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 87: 177-84. PMID 23089186 DOI: 10.1016/J.Plefa.2012.09.003 |
0.814 |
|
| 2012 |
Gato WE, Hales DB, Means JC. Hepatic gene expression analysis of 2-aminoanthracene exposed Fisher-344 rats reveal patterns indicative of liver carcinoma and type 2 diabetes. The Journal of Toxicological Sciences. 37: 1001-16. PMID 23038007 DOI: 10.2131/Jts.37.1001 |
0.347 |
|
| 2012 |
Hales DB, Xiong Y, Tur-Kaspa I. The role of cytokines in the regulation of Leydig cell P450c17 gene expression. The Journal of Steroid Biochemistry and Molecular Biology. 43: 907-14. PMID 22217835 DOI: 10.1016/0960-0760(92)90318-D |
0.302 |
|
| 2012 |
Eilati E, Pan L, Bahr JM, Hales DB. Abstract 4616: Age dependent increase in Prostaglandin pathway coincides with onset of ovarian cancer in laying hens Cancer Research. 72: 4616-4616. DOI: 10.1158/1538-7445.Am2012-4616 |
0.818 |
|
| 2012 |
Eilati E, Pan L, Bahr JM, Hales DB. Long-Term Consumption of Flaxseed-Enriched Diet Decreased Ovarian Cancer Incidence and PGE2 in Hens. Biology of Reproduction. 87: 549-549. DOI: 10.1093/Biolreprod/87.S1.549 |
0.795 |
|
| 2012 |
Speckman SC, Hales DB, Hales KH. Investigating Effects of Flaxseed on Expression of mir-200a, ZEB1, and E-Cadherin in Ovarian Cancer in the Laying Hen. Biology of Reproduction. 87: 546-546. DOI: 10.1093/Biolreprod/87.S1.546 |
0.375 |
|
| 2011 |
Barua A, Yellapa A, Bitterman P, Bahr JM, Sharma S, Hales DB, Luborsky JL, Abramowicz JS. Use of contrast-enhanced ultrasound imaging with microbubbles targeted to αvβ3 integrins to enhance detection of early-stage ovarian tumors. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 5076. PMID 28023669 DOI: 10.1200/Jco.2011.29.15_Suppl.5076 |
0.344 |
|
| 2011 |
Barua A, Bitterman P, Bahr JM, Basu S, Sheiner E, Bradaric MJ, Hales DB, Luborsky JL, Abramowicz JS. Contrast-enhanced sonography depicts spontaneous ovarian cancer at early stages in a preclinical animal model. Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine. 30: 333-45. PMID 21357555 DOI: 10.7863/Jum.2011.30.3.333 |
0.531 |
|
| 2010 |
Ansenberger K, Richards C, Zhuge Y, Barua A, Bahr JM, Luborsky JL, Hales DB. Decreased severity of ovarian cancer and increased survival in hens fed a flaxseed-enriched diet for 1 year. Gynecologic Oncology. 117: 341-7. PMID 20153884 DOI: 10.1016/J.Ygyno.2010.01.021 |
0.594 |
|
| 2010 |
Barua A, Bitterman P, Bahr JM, Bradaric MJ, Hales DB, Luborsky JL, Abramowicz JS. Detection of tumor-associated neoangiogenesis by Doppler ultrasonography during early-stage ovarian cancer in laying hens: a preclinical model of human spontaneous ovarian cancer. Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine. 29: 173-82. PMID 20103787 DOI: 10.7863/Jum.2010.29.2.173 |
0.362 |
|
| 2010 |
Barua A, Abramowicz JS, Bitterman P, Bahr JM, Braderic MJ, Edassery SL, Hales DB, Luborsky JL. Abstract A144: Anti‐NMP antibodies in association with tumor‐associated neoangiogenesis detects ovarian cancer at early stage Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-A144 |
0.401 |
|
| 2010 |
Ansenberger K, Paulus A, Bahr J, Hales DB. Flaxseed/Omega-3 Fatty Acid Suppression of E-Cadherin Expression in Ovarian Cancer in the Laying Hen: Molecular Target for Dietary Intervention. Biology of Reproduction. 83: 189-189. DOI: 10.1093/Biolreprod/83.S1.189 |
0.485 |
|
| 2009 |
Barua A, Bitterman P, Abramowicz JS, Dirks AL, Bahr JM, Hales DB, Bradaric MJ, Edassery SL, Rotmensch J, Luborsky JL. Histopathology of ovarian tumors in laying hens: a preclinical model of human ovarian cancer. International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society. 19: 531-9. PMID 19509547 DOI: 10.1111/Igc.0B013E3181A41613 |
0.43 |
|
| 2009 |
Barua A, Edassery SL, Bitterman P, Abramowicz JS, Dirks AL, Bahr JM, Hales DB, Bradaric MJ, Luborsky JL. Prevalence of antitumor antibodies in laying hen model of human ovarian cancer. International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society. 19: 500-7. PMID 19509543 DOI: 10.1111/Igc.0B013E3181A39Db1 |
0.466 |
|
| 2009 |
Ansenberger K, Zhuge Y, Lagman JA, Richards C, Barua A, Bahr JM, Hales DB. E-cadherin expression in ovarian cancer in the laying hen, Gallus domesticus, compared to human ovarian cancer. Gynecologic Oncology. 113: 362-9. PMID 19321195 DOI: 10.1016/J.Ygyno.2009.02.011 |
0.577 |
|
| 2009 |
Locke JA, Fazli L, Adomat H, Smyl J, Weins K, Lubik AA, Hales DB, Nelson CC, Gleave ME, Tomlinson Guns ES. A novel communication role for CYP17A1 in the progression of castration-resistant prostate cancer. The Prostate. 69: 928-37. PMID 19267349 DOI: 10.1002/Pros.20940 |
0.382 |
|
| 2009 |
Attar E, Tokunaga H, Imir G, Yilmaz MB, Redwine D, Putman M, Gurates B, Attar R, Yaegashi N, Hales DB, Bulun SE. Prostaglandin E2 via steroidogenic factor-1 coordinately regulates transcription of steroidogenic genes necessary for estrogen synthesis in endometriosis. The Journal of Clinical Endocrinology and Metabolism. 94: 623-31. PMID 19001523 DOI: 10.1210/Mend.23.1.9997 |
0.339 |
|
| 2009 |
Zhuge Y, Lagman JA, Ansenberger K, Mahon CJ, Daikoku T, Dey SK, Bahr JM, Hales DB. CYP1B1 expression in ovarian cancer in the laying hen Gallusdomesticus. Gynecologic Oncology. 112: 171-8. PMID 18973935 DOI: 10.1016/J.Ygyno.2008.09.026 |
0.555 |
|
| 2009 |
Barua A, Sheiner E, Bitterman P, Bahr JM, Hales DB, Luborsky JL, Abramowicz JS. 0526: Detection of Early Ovarian Tumor Associated Neo-Angiogenesis by Contrast-Enhanced Ultrasound in Laying Hens, a Spontaneous Animal Model of Human Ovarian Cancer Ultrasound in Medicine & Biology. 35: S75. DOI: 10.1016/J.Ultrasmedbio.2009.06.292 |
0.483 |
|
| 2008 |
Hales DB, Zhuge Y, Lagman JA, Ansenberger K, Mahon C, Barua A, Luborsky JL, Bahr JM. Cyclooxygenases expression and distribution in the normal ovary and their role in ovarian cancer in the domestic hen (Gallus domesticus). Endocrine. 33: 235-44. PMID 18498063 DOI: 10.1007/S12020-008-9080-Z |
0.584 |
|
| 2008 |
Stammer K, Edassery SL, Barua A, Bitterman P, Bahr JM, Hales DB, Luborsky JL. Selenium-Binding Protein 1 expression in ovaries and ovarian tumors in the laying hen, a spontaneous model of human ovarian cancer. Gynecologic Oncology. 109: 115-21. PMID 18272210 DOI: 10.1016/J.Ygyno.2007.12.030 |
0.568 |
|
| 2008 |
Ansenberger K, Zhuge Y, Mahon C, Barua A, Luborsky J, Bahr J, Hales DB. Flaxseed/Omega-3 Fatty Acid Dietary Intervention in Ovarian Cancer in the Laying Hen, Gallus Domesticus. Biology of Reproduction. 78: 223-224. DOI: 10.1093/Biolreprod/78.S1.223C |
0.485 |
|
| 2007 |
Ansenberger K, Zhuge Y, Lagman JA, Mahon C, Bahr J, Hales D. EPITHELIAL LINEAGE OF OVARIAN CARCINOMA OF THE LAYING HEN Gallus domesticus Biology of Reproduction. 77: 157-157. DOI: 10.1093/Biolreprod/77.S1.157A |
0.319 |
|
| 2005 |
Hales DB, Allen JA, Shankara T, Janus P, Buck S, Diemer T, Hales KH. Mitochondrial function in Leydig cell steroidogenesis. Annals of the New York Academy of Sciences. 1061: 120-34. PMID 16469751 DOI: 10.1196/Annals.1336.014 |
0.312 |
|
| 2004 |
Payne AH, Hales DB. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Endocrine Reviews. 25: 947-70. PMID 15583024 DOI: 10.1210/Er.2003-0030 |
0.342 |
|
| 2003 |
Provost AC, Péquignot MO, Sainton KM, Gadin S, Sallé S, Marchant D, Hales DB, Abitbol M. Expression of SR-BI receptor and StAR protein in rat ocular tissues. Comptes Rendus Biologies. 326: 841-51. PMID 14694755 DOI: 10.1016/J.Crvi.2003.09.001 |
0.301 |
|
| 2003 |
Diemer T, Allen JA, Hales KH, Hales DB. Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis. Endocrinology. 144: 2882-91. PMID 12810543 DOI: 10.1210/En.2002-0090 |
0.317 |
|
| 2003 |
Hales DB. Testicular macrophage modulation of Leydig cell steroidogenesis. Journal of Reproductive Immunology. 57: 3-18. PMID 12385830 DOI: 10.1016/S0165-0378(02)00020-7 |
0.317 |
|
| 2002 |
Sorianello E, Fritz S, Beyer C, Hales DB, Mayerhofer A, Libertun C, Lux-Lantos V. Development of an experimental ovarian tumor: immunocytochemical analysis. European Journal of Endocrinology. 147: 387-395. PMID 12213677 DOI: 10.1530/Eje.0.1470387 |
0.365 |
|
| 2002 |
Moons DS, Jirawatnotai S, Tsutsui T, Franks R, Parlow AF, Hales DB, Gibori G, Fazleabas AT, Kiyokawa H. Intact follicular maturation and defective luteal function in mice deficient for cyclin- dependent kinase-4. Endocrinology. 143: 647-54. PMID 11796521 DOI: 10.1210/Endo.143.2.8611 |
0.304 |
|
| 2001 |
Fritz S, Grünert R, Stocco DM, Hales DB, Mayerhofer A. StAR protein is increased by muscarinic receptor activation in human luteinized granulosa cells. Molecular and Cellular Endocrinology. 171: 49-51. PMID 11165010 DOI: 10.1016/S0303-7207(00)00420-2 |
0.328 |
|
| 2000 |
Hales KH, Diemer T, Ginde S, Shankar BK, Roberts M, Bosmann HB, Hales DB. Diametric effects of bacterial endotoxin lipopolysaccharide on adrenal and Leydig cell steroidogenic acute regulatory protein. Endocrinology. 141: 4000-12. PMID 11089530 DOI: 10.1210/Endo.141.11.7780 |
0.335 |
|
| 1999 |
Fiedler EP, Plouffe L, Hales DB, Hales KH, Khan I. Prostaglandin F(2alpha) induces a rapid decline in progesterone production and steroidogenic acute regulatory protein expression in isolated rat corpus luteum without altering messenger ribonucleic acid expression. Biology of Reproduction. 61: 643-50. PMID 10456840 DOI: 10.1095/Biolreprod61.3.643 |
0.316 |
|
| 1999 |
Sam AD, Sharma AC, Lee LY, Hales DB, Law WR, Ferguson JL, Bosmann HB. Sepsis produces depression of testosterone and steroidogenic acute regulatory (StAR) protein Shock. 11: 298-301. PMID 10220309 DOI: 10.1097/00024382-199904000-00013 |
0.315 |
|
| 1998 |
Fleury A, Ducharme L, Hales DB, Stocco DM, LeHoux JG. Acute in vivo effects of ACTH on the expression of steroidogenic acute regulatory protein in rat adrenal Endocrine Research. 24: 571-574. PMID 9888539 DOI: 10.3109/07435809809032647 |
0.308 |
|
| 1998 |
Xiong Y, Hales DB. Differential effects of tumor necrosis factor-alpha and interleukin-1 on 3 beta-hydroxysteroid dehydrogenase/delta 5-->delta 4 isomerase expression in mouse Leydig cells. Endocrine. 7: 295-301. PMID 9657065 DOI: 10.1007/Bf02801322 |
0.302 |
|
| 1998 |
Ronen-Fuhrmann T, Timberg R, King SR, Hales KH, Hales DB, Stocco DM, Orly J. Spatio-temporal expression patterns of steroidogenic acute regulatory protein (StAR) during follicular development in the rat ovary. Endocrinology. 139: 303-15. PMID 9421428 DOI: 10.1210/Endo.139.1.5694 |
0.365 |
|
| 1997 |
Clark BJ, Combs R, Hales KH, Hales DB, Stocco DM. Inhibition of transcription affects synthesis of steroidogenic acute regulatory protein and steroidogenesis in MA-10 mouse Leydig tumor cells. Endocrinology. 138: 4893-901. PMID 9348220 DOI: 10.1210/Endo.138.11.5535 |
0.316 |
|
| 1997 |
McLean MP, Warden KJ, Sandhoff TW, Irby RB, Hales DB. Altered ovarian sterol carrier protein expression in the pregnant streptozotocin-treated diabetic rat. Biology of Reproduction. 55: 38-46. PMID 8793056 DOI: 10.1095/Biolreprod55.1.38 |
0.309 |
|
| 1996 |
Bosmann HB, Hales KH, Li X, Liu Z, Stocco DM, Hales DB. Acute in vivo inhibition of testosterone by endotoxin parallels loss of steroidogenic acute regulatory (StAR) protein in Leydig cells. Endocrinology. 137: 4522-5. PMID 8828518 DOI: 10.1210/Endo.137.10.8828518 |
0.316 |
|
| 1992 |
Durkee TJ, McLean MP, Hales DB, Payne AH, Waterman MR, Khan I, Gibori G. P450(17 alpha) and P450SCC gene expression and regulation in the rat placenta. Endocrinology. 130: 1309-17. PMID 1537294 DOI: 10.1210/Endo.130.3.1537294 |
0.31 |
|
| 1990 |
Hales DB, Sha L, Payne AH. Glucocorticoid and cyclic adenosine 3'5'-monophosphate-mediated induction of cholesterol side-chain cleavage cytochrome P450 (P450scc) in MA-10 tumor Leydig cells. Increases in mRNA are cycloheximide sensitive. Endocrinology. 126: 2800-8. PMID 2161734 DOI: 10.1210/Endo-126-6-2800 |
0.325 |
|
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