| Year |
Citation |
Score |
| 2023 |
Zhao Y, Tabet D, Rubio Contreras D, Lao L, Kousholt AN, Weile J, Melo H, Hoeg L, Feng S, Coté AG, Lin ZY, Setiaputra D, Jonkers J, Gingras AC, Gómez Herreros F, ... ... Durocher D, et al. Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens. Molecular Cell. PMID 37478847 DOI: 10.1016/j.molcel.2023.06.025 |
0.522 |
|
| 2023 |
Sifri C, Hoeg L, Durocher D, Setiaputra D. An AlphaFold2 map of the 53BP1 pathway identifies a direct SHLD3-RIF1 interaction critical for shieldin activity. Embo Reports. e56834. PMID 37306046 DOI: 10.15252/embr.202356834 |
0.463 |
|
| 2022 |
De Marco Zompit M, Esteban MT, Mooser C, Adam S, Rossi SE, Jeanrenaud A, Leimbacher PA, Fink D, Shorrocks AK, Blackford AN, Durocher D, Stucki M. The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis. Nature Communications. 13: 4143. PMID 35842428 DOI: 10.1038/s41467-022-31865-5 |
0.784 |
|
| 2022 |
Setiaputra D, Escribano-Díaz C, Reinert JK, Sadana P, Zong D, Callen E, Sifri C, Seebacher J, Nussenzweig A, Thomä NH, Durocher D. RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1. Molecular Cell. PMID 35216668 DOI: 10.1016/j.molcel.2022.01.025 |
0.54 |
|
| 2021 |
Adam S, Rossi SE, Moatti N, De Marco Zompit M, Xue Y, Ng TF, Álvarez-Quilón A, Desjardins J, Bhaskaran V, Martino G, Setiaputra D, Noordermeer SM, Ohsumi TK, Hustedt N, Szilard RK, ... ... Durocher D, et al. The CIP2A-TOPBP1 axis safeguards chromosome stability and is a synthetic lethal target for BRCA-mutated cancer. Nature Cancer. 2: 1357-1371. PMID 35121901 DOI: 10.1038/s43018-021-00266-w |
0.379 |
|
| 2021 |
Feng Y, Li C, Stewart JA, Barbulescu P, Desivo NS, Álvarez-Quilón A, Pezo RC, Perera MLW, Chan K, Tong AHY, Mohamad-Ramshan R, Berru M, Nakib D, Li G, Kardar GA, ... ... Durocher D, et al. FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation. Nature. PMID 34819670 DOI: 10.1038/s41586-021-04144-4 |
0.446 |
|
| 2021 |
Sherker A, Chaudhary N, Adam S, Heijink AM, Noordermeer SM, Fradet-Turcotte A, Durocher D. Two redundant ubiquitin-dependent pathways of BRCA1 localization to DNA damage sites. Embo Reports. e53679. PMID 34726323 DOI: 10.15252/embr.202153679 |
0.478 |
|
| 2020 |
Olivieri M, Cho T, Álvarez-Quilón A, Li K, Schellenberg MJ, Zimmermann M, Hustedt N, Rossi SE, Adam S, Melo H, Heijink AM, Sastre-Moreno G, Moatti N, Szilard RK, McEwan A, ... ... Durocher D, et al. A Genetic Map of the Response to DNA Damage in Human Cells. Cell. PMID 32649862 DOI: 10.1016/J.Cell.2020.05.040 |
0.587 |
|
| 2020 |
Ling AK, Munro M, Chaudhary N, Li C, Berru M, Wu B, Durocher D, Martin A. SHLD2 promotes class switch recombination by preventing inactivating deletions within the Igh locus. Embo Reports. e49823. PMID 32558186 DOI: 10.15252/Embr.201949823 |
0.398 |
|
| 2020 |
Álvarez-Quilón A, Wojtaszek JL, Mathieu MC, Patel T, Appel CD, Hustedt N, Rossi SE, Wallace BD, Setiaputra D, Adam S, Ohashi Y, Melo H, Cho T, Gervais C, Muñoz IM, ... ... Durocher D, et al. Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Molecular Cell. PMID 32516598 DOI: 10.1016/J.Molcel.2020.05.021 |
0.598 |
|
| 2019 |
Hustedt N, Álvarez-Quilón A, McEwan A, Yuan JY, Cho T, Koob L, Hart T, Durocher D. A consensus set of genetic vulnerabilities to ATR inhibition. Open Biology. 9: 190156. PMID 31506018 DOI: 10.1098/Rsob.190156 |
0.635 |
|
| 2019 |
Hustedt N, Saito Y, Zimmermann M, Álvarez-Quilón A, Setiaputra D, Adam S, McEwan A, Yuan JY, Olivieri M, Zhao Y, Kanemaki MT, Jurisicova A, Durocher D. Control of homologous recombination by the HROB-MCM8-MCM9 pathway. Genes & Development. PMID 31467087 DOI: 10.1101/Gad.329508.119 |
0.652 |
|
| 2019 |
Setiaputra D, Durocher D. Shieldin - the protector of DNA ends. Embo Reports. PMID 30948458 DOI: 10.15252/Embr.201847560 |
0.644 |
|
| 2019 |
Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, ... Durocher D, et al. BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation. Molecular Cell. PMID 30704900 DOI: 10.1016/J.Molcel.2018.12.010 |
0.592 |
|
| 2019 |
Durocher D. Abstract PL03-03: Navigating gene-gene and drug-gene interaction landscapes underpinning the DNA damage response Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-Pl03-03 |
0.476 |
|
| 2018 |
Noordermeer SM, Adam S, Setiaputra D, Barazas M, Pettitt SJ, Ling AK, Olivieri M, Álvarez-Quilón A, Moatti N, Zimmermann M, Annunziato S, Krastev DB, Song F, Brandsma I, Frankum J, ... ... Durocher D, et al. The shieldin complex mediates 53BP1-dependent DNA repair. Nature. PMID 30022168 DOI: 10.1038/S41586-018-0340-7 |
0.648 |
|
| 2018 |
Mirman Z, Lottersberger F, Takai H, Kibe T, Gong Y, Takai K, Bianchi A, Zimmermann M, Durocher D, de Lange T. 53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polα-dependent fill-in. Nature. PMID 30022158 DOI: 10.1038/S41586-018-0324-7 |
0.586 |
|
| 2018 |
Zimmermann M, Murina O, Reijns MAM, Agathanggelou A, Challis R, Tarnauskaitė Ž, Muir M, Fluteau A, Aregger M, McEwan A, Yuan W, Clarke M, Lambros MB, Paneesha S, Moss P, ... ... Durocher D, et al. CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions. Nature. PMID 29973717 DOI: 10.1038/S41586-018-0291-Z |
0.51 |
|
| 2018 |
Díaz-Mejía JJ, Celaj A, Mellor JC, Coté A, Balint A, Ho B, Bansal P, Shaeri F, Gebbia M, Weile J, Verby M, Karkhanina A, Zhang Y, Wong C, Rich J, ... ... Durocher D, et al. Mapping DNA damage-dependent genetic interactions in yeast via party mating and barcode fusion genetics. Molecular Systems Biology. 14: e7985. PMID 29807908 DOI: 10.15252/Msb.20177985 |
0.432 |
|
| 2017 |
Batenburg NL, Walker JR, Noordermeer SM, Moatti N, Durocher D, Zhu XD. ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice. Nature Communications. 8: 1921. PMID 29203878 DOI: 10.1038/S41467-017-02114-X |
0.56 |
|
| 2017 |
Canny MD, Moatti N, Wan LCK, Fradet-Turcotte A, Krasner D, Mateos-Gomez PA, Zimmermann M, Orthwein A, Juang YC, Zhang W, Noordermeer SM, Seclen E, Wilson MD, Vorobyov A, Munro M, ... ... Durocher D, et al. Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency. Nature Biotechnology. PMID 29176614 DOI: 10.1038/Nbt.4021 |
0.561 |
|
| 2017 |
Wilson MD, Durocher D. Reading chromatin signatures after DNA double-strand breaks. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 372. PMID 28847817 DOI: 10.1098/Rstb.2016.0280 |
0.647 |
|
| 2017 |
Strecker J, Stinus S, Caballero MP, Szilard RK, Chang M, Durocher D. A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres. Elife. 6. PMID 28826474 DOI: 10.7554/Elife.23783 |
0.581 |
|
| 2017 |
Kitevski-LeBlanc J, Fradet-Turcotte A, Kukic P, Wilson MD, Portella G, Yuwen T, Panier S, Duan S, Canny MD, van Ingen H, Arrowsmith CH, Rubinstein JL, Vendruscolo M, Durocher D, Kay LE. The RNF168 paralog RNF169 defines a new class of ubiquitylated-histone reader involved in the response to DNA damage. Elife. 6. PMID 28406400 DOI: 10.7554/Elife.23872 |
0.799 |
|
| 2017 |
Leung JW, Makharashvili N, Agarwal P, Chiu LY, Pourpre R, Cammarata MB, Cannon JR, Sherker A, Durocher D, Brodbelt JS, Paull TT, Miller KM. ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair. Genes & Development. PMID 28242625 DOI: 10.1101/Gad.292516.116 |
0.769 |
|
| 2017 |
Kitevski-LeBlanc J, Fradet-Turcotte A, Kukic P, Wilson MD, Portella G, Yuwen T, Panier S, Duan S, Canny MD, Ingen Hv, Arrowsmith CH, Rubinstein JL, Vendruscolo M, Durocher D, Kay LE. Author response: The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage Elife. DOI: 10.7554/Elife.23872.024 |
0.804 |
|
| 2017 |
Strecker J, Stinus S, Caballero MP, Szilard RK, Chang M, Durocher D. Author response: A sharp Pif1-dependent threshold separates DNA double-strand breaks from critically short telomeres Elife. DOI: 10.7554/Elife.23783.043 |
0.578 |
|
| 2017 |
Durocher D. Abstract IA05: Prospective identification of vulnerabilities to DNA repair inhibitors Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-Ia05 |
0.552 |
|
| 2017 |
Young J, Bashkurov M, McEwan A, Sun T, Datti A, Durocher D. Abstract B45: A genome-scale screen identifies the microcephaly gene, ZNF335, as a regulator of DNA end resection Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-B45 |
0.595 |
|
| 2016 |
Hustedt N, Durocher D. The control of DNA repair by the cell cycle. Nature Cell Biology. 19: 1-9. PMID 28008184 DOI: 10.1038/Ncb3452 |
0.616 |
|
| 2016 |
Wan LC, Maisonneuve P, Szilard RK, Lambert JP, Ng TF, Manczyk N, Huang H, Laister R, Caudy AA, Gingras AC, Durocher D, Sicheri F. Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7. Nucleic Acids Research. PMID 27903914 DOI: 10.1093/Nar/Gkw1181 |
0.318 |
|
| 2016 |
Connor AA, Denroche RE, Jang GH, Timms L, Kalimuthu SN, Selander I, McPherson T, Wilson GW, Chan-Seng-Yue MA, Borozan I, Ferretti V, Grant RC, Lungu IM, Costello E, Greenhalf W, ... ... Durocher D, et al. Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma. Jama Oncology. PMID 27768182 DOI: 10.1001/Jamaoncol.2016.3916 |
0.331 |
|
| 2016 |
Durocher D, Pelletier L. 53BP1 Goes Back to Its p53 Roots. Molecular Cell. 64: 3-4. PMID 27716486 DOI: 10.1016/J.Molcel.2016.09.024 |
0.428 |
|
| 2016 |
Rugy TGd, Bashkurov M, Datti A, Betous R, Guitton-Sert L, Cazaux C, Durocher D, Hoffmann JS. Excess Polθ functions in response to replicative stress in homologous recombination-proficient cancer cells Biology Open. 5: 1485-1492. PMID 27612511 DOI: 10.1242/Bio.018028 |
0.51 |
|
| 2016 |
Wilson MD, Benlekbir S, Fradet-Turcotte A, Sherker A, Julien JP, McEwan A, Noordermeer SM, Sicheri F, Rubinstein JL, Durocher D. The structural basis of modified nucleosome recognition by 53BP1. Nature. PMID 27462807 DOI: 10.1038/Nature18951 |
0.508 |
|
| 2016 |
Wan LC, Pillon MC, Thevakumaran N, Sun Y, Chakrabartty A, Guarné A, Kurinov I, Durocher D, Sicheri F. Structural and functional characterization of KEOPS dimerization by Pcc1 and its role in t6A biosynthesis. Nucleic Acids Research. PMID 27302132 DOI: 10.1093/Nar/Gkw542 |
0.327 |
|
| 2016 |
Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D, Côté J. The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation. Molecular Cell. 62: 409-21. PMID 27153538 DOI: 10.1016/J.Molcel.2016.03.031 |
0.473 |
|
| 2016 |
Strecker J, Gupta GD, Zhang W, Bashkurov M, Landry MC, Pelletier L, Durocher D. DNA damage signalling targets the kinetochore to promote chromatin mobility. Nature Cell Biology. PMID 26829389 DOI: 10.1038/Ncb3308 |
0.572 |
|
| 2016 |
Tkáč J, Xu G, Adhikary H, Young JT, Gallo D, Escribano-Díaz C, Krietsch J, Orthwein A, Munro M, Sol W, Al-Hakim A, Lin ZY, Jonkers J, Borst P, Brown GW, ... ... Durocher D, et al. HELB Is a Feedback Inhibitor of DNA End Resection. Molecular Cell. PMID 26774285 DOI: 10.1016/J.Molcel.2015.12.013 |
0.58 |
|
| 2016 |
Durocher D. Abstract IA06: Regulation of BRCA1- and BRCA2-dependent DNA repair. Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Ovca15-Ia06 |
0.559 |
|
| 2016 |
Hart T, Chandrashekhar M, Aregger M, Steinhart Z, Brown KR, Macleod G, Mis M, Zimmermann M, Fradet-Turcotte A, Sun S, Driks P, Sidhu S, Roth FP, Rissland OS, Durocher D, et al. Abstract PR03: High-resolution detection of fitness genes and genotype-specific cancer vulnerabilities with CRISPR-Cas9 screens Cancer Research. 76. DOI: 10.1158/1538-7445.Fbcr15-Pr03 |
0.305 |
|
| 2015 |
Orthwein A, Noordermeer SM, Wilson MD, Landry S, Enchev RI, Sherker A, Munro M, Pinder J, Salsman J, Dellaire G, Xia B, Peter M, Durocher D. A mechanism for the suppression of homologous recombination in G1 cells. Nature. PMID 26649820 DOI: 10.1038/Nature16142 |
0.534 |
|
| 2015 |
Campos EI, Smits AH, Kang YH, Landry S, Escobar TM, Nayak S, Ueberheide BM, Durocher D, Vermeulen M, Hurwitz J, Reinberg D. Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event. Molecular Cell. PMID 26527279 DOI: 10.1016/J.Molcel.2015.08.005 |
0.346 |
|
| 2015 |
Chung DK, Chan JN, Strecker J, Zhang W, Ebrahimi-Ardebili S, Lu T, Abraham KJ, Durocher D, Mekhail K. Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process. Nature Communications. 6: 7742. PMID 26205667 DOI: 10.1038/Ncomms8742 |
0.641 |
|
| 2015 |
Boersma V, Moatti N, Segura-Bayona S, Peuscher MH, van der Torre J, Wevers BA, Orthwein A, Durocher D, Jacobs JJ. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection. Nature. 521: 537-40. PMID 25799990 DOI: 10.1038/Nature14216 |
0.651 |
|
| 2014 |
Wybenga-Groot LE, Ho CS, Sweeney FD, Ceccarelli DF, McGlade CJ, Durocher D, Sicheri F. Structural basis of Rad53 kinase activation by dimerization and activation segment exchange Cellular Signalling. 26: 1825-1836. PMID 24815189 DOI: 10.1016/J.Cellsig.2014.05.004 |
0.418 |
|
| 2014 |
Orthwein A, Fradet-Turcotte A, Noordermeer SM, Canny MD, Brun CM, Strecker J, Escribano-Diaz C, Durocher D. Mitosis inhibits DNA double-strand break repair to guard against telomere fusions. Science (New York, N.Y.). 344: 189-93. PMID 24652939 DOI: 10.1126/Science.1248024 |
0.621 |
|
| 2014 |
Leung JW, Agarwal P, Canny MD, Gong F, Robison AD, Finkelstein IJ, Durocher D, Miller KM. Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling. Plos Genetics. 10: e1004178. PMID 24603765 DOI: 10.1371/Journal.Pgen.1004178 |
0.684 |
|
| 2014 |
Ramaekers CH, van den Beucken T, Bristow RG, Chiu RK, Durocher D, Wouters BG. RNF8-independent Lys63 poly-ubiquitylation prevents genomic instability in response to replication-associated DNA damage. Plos One. 9: e89997. PMID 24587176 DOI: 10.1371/Journal.Pone.0089997 |
0.588 |
|
| 2014 |
Orthwein A, Durocher D. Abstract IA12: Regulation of the RNF168-dependent response to DNA double-strand breaks Cancer Research. 74. DOI: 10.1158/1538-7445.Cansusc14-Ia12 |
0.621 |
|
| 2013 |
Panier S, Durocher D. Push back to respond better: regulatory inhibition of the DNA double-strand break response. Nature Reviews. Molecular Cell Biology. 14: 661-72. PMID 24002223 DOI: 10.1038/Nrm3659 |
0.84 |
|
| 2013 |
Escribano-Diaz C, Durocher D. DNA repair pathway choice--a PTIP of the hat to 53BP1. Embo Reports. 14: 665-6. PMID 23846307 DOI: 10.1038/Embor.2013.99 |
0.615 |
|
| 2013 |
Fradet-Turcotte A, Canny MD, Escribano-DÃaz C, Orthwein A, Leung CC, Huang H, Landry MC, Kitevski-LeBlanc J, Noordermeer SM, Sicheri F, Durocher D. 53BP1 is a reader of the DNA-damage-induced H2A Lys 15 ubiquitin mark. Nature. 499: 50-4. PMID 23760478 DOI: 10.1038/Nature12318 |
0.561 |
|
| 2013 |
Wan LC, Mao DY, Neculai D, Strecker J, Chiovitti D, Kurinov I, Poda G, Thevakumaran N, Yuan F, Szilard RK, Lissina E, Nislow C, Caudy AA, Durocher D, Sicheri F. Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Nucleic Acids Research. 41: 6332-46. PMID 23620299 DOI: 10.1093/Nar/Gkt322 |
0.311 |
|
| 2013 |
Jackson SP, Durocher D. Regulation of DNA damage responses by ubiquitin and SUMO. Molecular Cell. 49: 795-807. PMID 23416108 DOI: 10.1016/J.Molcel.2013.01.017 |
0.717 |
|
| 2013 |
Escribano-DÃaz C, Orthwein A, Fradet-Turcotte A, Xing M, Young JT, TkÃ¡Ä J, Cook MA, Rosebrock AP, Munro M, Canny MD, Xu D, Durocher D. A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Molecular Cell. 49: 872-83. PMID 23333306 DOI: 10.1016/J.Molcel.2013.01.001 |
0.562 |
|
| 2013 |
Ernst A, Avvakumov G, Tong J, Fan Y, Zhao Y, Alberts P, Persaud A, Walker JR, Neculai AM, Neculai D, Vorobyov A, Garg P, Beatty L, Chan PK, Juang YC, ... ... Durocher D, et al. A strategy for modulation of enzymes in the ubiquitin system. Science (New York, N.Y.). 339: 590-5. PMID 23287719 DOI: 10.1126/Science.1230161 |
0.324 |
|
| 2012 |
Panier S, Ichijima Y, Fradet-Turcotte A, Leung CC, Kaustov L, Arrowsmith CH, Durocher D. Tandem protein interaction modules organize the ubiquitin-dependent response to DNA double-strand breaks. Molecular Cell. 47: 383-95. PMID 22742833 DOI: 10.1016/J.Molcel.2012.05.045 |
0.836 |
|
| 2012 |
Yang J, O'Donnell L, Durocher D, Brown GW. RMI1 promotes DNA replication fork progression and recovery from replication fork stress. Molecular and Cellular Biology. 32: 3054-64. PMID 22645306 DOI: 10.1128/Mcb.00255-12 |
0.596 |
|
| 2012 |
Juang YC, Landry MC, Sanches M, Vittal V, Leung CC, Ceccarelli DF, Mateo AR, Pruneda JN, Mao DY, Szilard RK, Orlicky S, Munro M, Brzovic PS, Klevit RE, Sicheri F, ... Durocher D, et al. OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function. Molecular Cell. 45: 384-97. PMID 22325355 DOI: 10.1016/J.Molcel.2012.01.011 |
0.39 |
|
| 2012 |
Al-Hakim AK, Bashkurov M, Gingras AC, Durocher D, Pelletier L. Interaction proteomics identify NEURL4 and the HECT E3 ligase HERC2 as novel modulators of centrosome architecture. Molecular & Cellular Proteomics : McP. 11: M111.014233. PMID 22261722 DOI: 10.1074/Mcp.M111.014233 |
0.331 |
|
| 2012 |
Durocher D. Abstract SY07-03: The ubiquitin-based response to DNA double-strand breaks Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Sy07-03 |
0.604 |
|
| 2012 |
Griffin C, Abibi A, Subramaniam R, Zaidi HS, Marcellus R, Poda G, Prakesch M, Uehling D, Canny M, Chiovitti D, Durocher D, Sicheri F, Al-awar R. Abstract 4989: Selective inhibitors of the inositol-requiring enzyme 1 kinase domain Cancer Research. 72: 4989-4989. DOI: 10.1158/1538-7445.Am2012-4989 |
0.309 |
|
| 2011 |
Yeung M, Durocher D. Srs2 enables checkpoint recovery by promoting disassembly of DNA damage foci from chromatin. Dna Repair. 10: 1213-22. PMID 21982442 DOI: 10.1016/J.Dnarep.2011.09.005 |
0.855 |
|
| 2011 |
Lackner DH, Durocher D, Karlseder J. A siRNA-based screen for genes involved in chromosome end protection. Plos One. 6: e21407. PMID 21760879 DOI: 10.1371/Journal.Pone.0021407 |
0.556 |
|
| 2011 |
Ceccarelli DF, Tang X, Pelletier B, Orlicky S, Xie W, Plantevin V, Neculai D, Chou YC, Ogunjimi A, Al-Hakim A, Varelas X, Koszela J, Wasney GA, Vedadi M, Dhe-Paganon S, ... ... Durocher D, et al. An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme. Cell. 145: 1075-87. PMID 21683433 DOI: 10.1016/J.Cell.2011.05.039 |
0.3 |
|
| 2011 |
Fraser M, Harding SM, Zhao H, Coackley C, Durocher D, Bristow RG. MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks. Cell Cycle (Georgetown, Tex.). 10: 2218-32. PMID 21623170 DOI: 10.4161/Cc.10.13.16305 |
0.586 |
|
| 2011 |
Bohgaki T, Bohgaki M, Cardoso R, Panier S, Zeegers D, Li L, Stewart GS, Sanchez O, Hande MP, Durocher D, Hakem A, Hakem R. Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome. Plos Genetics. 7: e1001381. PMID 21552324 DOI: 10.1371/Journal.Pgen.1001381 |
0.832 |
|
| 2010 |
Al-Hakim A, Escribano-Diaz C, Landry MC, O'Donnell L, Panier S, Szilard RK, Durocher D. The ubiquitous role of ubiquitin in the DNA damage response. Dna Repair. 9: 1229-40. PMID 21056014 DOI: 10.1016/J.Dnarep.2010.09.011 |
0.84 |
|
| 2010 |
O'Donnell L, Panier S, Wildenhain J, Tkach JM, Al-Hakim A, Landry MC, Escribano-Diaz C, Szilard RK, Young JT, Munro M, Canny MD, Kolas NK, Zhang W, Harding SM, Ylanko J, ... ... Durocher D, et al. The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination. Molecular Cell. 40: 619-31. PMID 21055983 DOI: 10.1016/J.Molcel.2010.10.024 |
0.835 |
|
| 2010 |
Nakada S, Tai I, Panier S, Al-Hakim A, Iemura SI, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D. Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1 Nature. 466: 941-946. PMID 20725033 DOI: 10.1038/Nature09297 |
0.839 |
|
| 2010 |
O'Donnell L, Durocher D. DNA repair has a new FAN1 club. Molecular Cell. 39: 167-9. PMID 20670886 DOI: 10.1016/J.Molcel.2010.07.010 |
0.414 |
|
| 2010 |
Li L, Halaby MJ, Hakem A, Cardoso R, El Ghamrasni S, Harding S, Chan N, Bristow R, Sanchez O, Durocher D, Hakem R. Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer. The Journal of Experimental Medicine. 207: 983-97. PMID 20385750 DOI: 10.1084/Jem.20092437 |
0.626 |
|
| 2010 |
Zhang W, Durocher D. De novo telomere formation is suppressed by the Mec1-dependent inhibition of Cdc13 accumulation at DNA breaks. Genes & Development. 24: 502-15. PMID 20194442 DOI: 10.1101/Gad.1869110 |
0.622 |
|
| 2010 |
Szilard RK, Jacques PE, Laramée L, Cheng B, Galicia S, Bataille AR, Yeung M, Mendez M, Bergeron M, Robert F, Durocher D. Systematic identification of fragile sites via genome-wide location analysis of gamma-H2AX. Nature Structural & Molecular Biology. 17: 299-305. PMID 20139982 DOI: 10.1038/Nsmb.1754 |
0.801 |
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| 2010 |
Vidanes GM, Sweeney FD, Galicia S, Cheung S, Doyle JP, Durocher D, Toczyski DP. CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation. Plos Biology. 8: e1000286. PMID 20126259 DOI: 10.1371/Journal.Pbio.1000286 |
0.785 |
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| 2010 |
Ramachandran S, Chahwan R, Nepal RM, Frieder D, Panier S, Roa S, Zaheen A, Durocher D, Scharff MD, Martin A. The RNF8/RNF168 ubiquitin ligase cascade facilitates class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. 107: 809-14. PMID 20080757 DOI: 10.1073/Pnas.0913790107 |
0.803 |
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| 2010 |
Lilley CE, Chaurushiya MS, Boutell C, Landry S, Suh J, Panier S, Everett RD, Stewart GS, Durocher D, Weitzman MD. A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses. The Embo Journal. 29: 943-55. PMID 20075863 DOI: 10.1038/Emboj.2009.400 |
0.839 |
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| 2009 |
Panier S, Durocher D. Regulatory ubiquitylation in response to DNA double-strand breaks. Dna Repair. 8: 436-43. PMID 19230794 DOI: 10.1016/J.Dnarep.2009.01.013 |
0.854 |
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| 2009 |
Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, Lukas J, Lukas C. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell. 136: 435-46. PMID 19203579 DOI: 10.1016/J.Cell.2008.12.041 |
0.817 |
|
| 2009 |
Stewart GS, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, Nakada S, Ylanko J, Olivarius S, Mendez M, Oldreive C, Wildenhain J, Tagliaferro A, Pelletier L, Taubenheim N, ... ... Durocher D, et al. The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell. 136: 420-34. PMID 19203578 DOI: 10.1016/J.Cell.2008.12.042 |
0.829 |
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| 2008 |
Mao DY, Neculai D, Downey M, Orlicky S, Haffani YZ, Ceccarelli DF, Ho JS, Szilard RK, Zhang W, Ho CS, Wan L, Fares C, Rumpel S, Kurinov I, Arrowsmith CH, ... Durocher D, et al. Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. Molecular Cell. 32: 259-75. PMID 18951093 DOI: 10.1016/J.Molcel.2008.10.002 |
0.598 |
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| 2008 |
Dixon SJ, Fedyshyn Y, Koh JL, Prasad TS, Chahwan C, Chua G, Toufighi K, Baryshnikova A, Hayles J, Hoe KL, Kim DU, Park HO, Myers CL, Pandey A, Durocher D, et al. Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Proceedings of the National Academy of Sciences of the United States of America. 105: 16653-8. PMID 18931302 DOI: 10.1073/Pnas.0806261105 |
0.323 |
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| 2008 |
Addinall SG, Downey M, Yu M, Zubko MK, Dewar J, Leake A, Hallinan J, Shaw O, James K, Wilkinson DJ, Wipat A, Durocher D, Lydall D. A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae. Genetics. 180: 2251-66. PMID 18845848 DOI: 10.1534/Genetics.108.092577 |
0.695 |
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| 2008 |
Nakada S, Chen GI, Gingras AC, Durocher D. PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint. Embo Reports. 9: 1019-26. PMID 18758438 DOI: 10.1038/Embor.2008.162 |
0.681 |
|
| 2008 |
Yeung M, Durocher D. Engineering a DNA damage response without DNA damage. Genome Biology. 9: 227. PMID 18671832 DOI: 10.1186/Gb-2008-9-7-227 |
0.852 |
|
| 2008 |
Zhang W, Durocher D. Dun1 counts on rad53 to be turned on. Molecular Cell. 31: 1-2. PMID 18614039 DOI: 10.1016/J.Molcel.2008.06.009 |
0.486 |
|
| 2008 |
Fu Y, Zhu Y, Zhang K, Yeung M, Durocher D, Xiao W. Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp. Cell. 133: 601-11. PMID 18485869 DOI: 10.1016/J.Cell.2008.02.050 |
0.855 |
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| 2008 |
Macrae CJ, McCulloch RD, Ylanko J, Durocher D, Koch CA. APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation. Dna Repair. 7: 292-302. PMID 18077224 DOI: 10.1016/J.Dnarep.2007.10.008 |
0.659 |
|
| 2007 |
Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, Pelletier L, Jackson SP, Durocher D. Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (New York, N.Y.). 318: 1637-40. PMID 18006705 DOI: 10.1126/Science.1150034 |
0.862 |
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| 2007 |
Kanellis P, Gagliardi M, Banath JP, Szilard RK, Nakada S, Galicia S, Sweeney FD, Cabelof DC, Olive PL, Durocher D. A screen for suppressors of gross chromosomal rearrangements identifies a conserved role for PLP in preventing DNA lesions. Plos Genetics. 3: e134. PMID 17696614 DOI: 10.1371/Journal.Pgen.0030134 |
0.554 |
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| 2006 |
Woolstencroft RN, Beilharz TH, Cook MA, Preiss T, Durocher D, Tyers M. Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length. Journal of Cell Science. 119: 5178-92. PMID 17158920 DOI: 10.1242/Jcs.03221 |
0.473 |
|
| 2006 |
Szilard RK, Durocher D. Telomere protection: an act of God. Current Biology : Cb. 16: R544-6. PMID 16860732 DOI: 10.1016/J.Cub.2006.06.037 |
0.578 |
|
| 2006 |
Downey M, Durocher D. gammaH2AX as a checkpoint maintenance signal. Cell Cycle (Georgetown, Tex.). 5: 1376-81. PMID 16855385 DOI: 10.4161/Cc.5.13.2899 |
0.712 |
|
| 2006 |
Blake D, Luke B, Kanellis P, Jorgensen P, Goh T, Penfold S, Breitkreutz BJ, Durocher D, Peter M, Tyers M. The F-box protein Dia2 overcomes replication impedance to promote genome stability in Saccharomyces cerevisiae. Genetics. 174: 1709-27. PMID 16751663 DOI: 10.1534/Genetics.106.057836 |
0.59 |
|
| 2006 |
Kolas NK, Durocher D. DNA repair: DNA polymerase zeta and Rev1 break in. Current Biology : Cb. 16: R296-9. PMID 16631579 DOI: 10.1016/J.Cub.2006.03.043 |
0.643 |
|
| 2006 |
Downey M, Houlsworth R, Maringele L, Rollie A, Brehme M, Galicia S, Guillard S, Partington M, Zubko MK, Krogan NJ, Emili A, Greenblatt JF, Harrington L, Lydall D, Durocher D. A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. Cell. 124: 1155-68. PMID 16564010 DOI: 10.1016/J.Cell.2005.12.044 |
0.667 |
|
| 2006 |
Downey M, Durocher D. Chromatin and DNA repair: the benefits of relaxation. Nature Cell Biology. 8: 9-10. PMID 16389287 DOI: 10.1038/Ncb0106-9 |
0.78 |
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| 2006 |
Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, et al. A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature. 439: 497-501. PMID 16299494 DOI: 10.1038/Nature04384 |
0.772 |
|
| 2006 |
Keogh M, Kim J, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, et al. Erratum: Corrigendum: A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery Nature. 441: 120-120. DOI: 10.1038/Nature04772 |
0.678 |
|
| 2005 |
Sweeney FD, Yang F, Chi A, Shabanowitz J, Hunt DF, Durocher D. Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation. Current Biology : Cb. 15: 1364-75. PMID 16085488 DOI: 10.1016/J.Cub.2005.06.063 |
0.604 |
|
| 2005 |
Bernstein NK, Williams RS, Rakovszky ML, Cui D, Green R, Karimi-Busheri F, Mani RS, Galicia S, Koch CA, Cass CE, Durocher D, Weinfeld M, Glover JN. The molecular architecture of the mammalian DNA repair enzyme, polynucleotide kinase. Molecular Cell. 17: 657-70. PMID 15749016 DOI: 10.1016/J.Molcel.2005.02.012 |
0.495 |
|
| 2004 |
Koch CA, Agyei R, Galicia S, Metalnikov P, O'Donnell P, Starostine A, Weinfeld M, Durocher D. Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV. The Embo Journal. 23: 3874-85. PMID 15385968 DOI: 10.1038/Sj.Emboj.7600375 |
0.644 |
|
| 2003 |
Kanellis P, Agyei R, Durocher D. Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability. Current Biology : Cb. 13: 1583-95. PMID 13678589 DOI: 10.1016/S0960-9822(03)00578-5 |
0.304 |
|
| 2003 |
Durocher D. Bacterial signal transduction: a FHAscinating glimpse at the origins of phospho-dependent signal transduction. Trends in Microbiology. 11: 67-8. PMID 12598127 DOI: 10.1016/S0966-842X(02)00032-X |
0.352 |
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| 2002 |
Li J, Williams BL, Haire LF, Goldberg M, Wilker E, Durocher D, Yaffe MB, Jackson SP, Smerdon SJ. Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Molecular Cell. 9: 1045-54. PMID 12049740 DOI: 10.1016/S1097-2765(02)00527-0 |
0.711 |
|
| 2002 |
Durocher D, Jackson SP. The FHA domain. Febs Letters. 513: 58-66. PMID 11911881 DOI: 10.1016/S0014-5793(01)03294-X |
0.531 |
|
| 2002 |
Ho Y, Gruhler A, Heilbut A, Bader GD, Moore L, Adams SL, Millar A, Taylor P, Bennett K, Boutilier K, Yang L, Wolting C, Donaldson I, Schandorff S, Shewnarane J, ... ... Durocher D, et al. Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 415: 180-3. PMID 11805837 DOI: 10.1038/415180A |
0.363 |
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| 2001 |
Durocher D, Jackson SP. DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme? Current Opinion in Cell Biology. 13: 225-31. PMID 11248557 DOI: 10.1016/S0955-0674(00)00201-5 |
0.753 |
|
| 2000 |
Durocher D, Smerdon SJ, Yaffe MB, Jackson SP. The FHA domain in DNA repair and checkpoint signaling Cold Spring Harbor Symposia On Quantitative Biology. 65: 423-431. PMID 12760058 DOI: 10.1101/Sqb.2000.65.423 |
0.753 |
|
| 2000 |
Durocher D, Taylor IA, Sarbassova D, Haire LF, Westcott SL, Jackson SP, Smerdon SJ, Yaffe MB. The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Molecular Cell. 6: 1169-82. PMID 11106755 DOI: 10.1016/S1097-2765(00)00114-3 |
0.684 |
|
| 1999 |
Durocher D, Henckel J, Fersht AR, Jackson SP. The FHA domain is a modular phosphopeptide recognition motif. Molecular Cell. 4: 387-94. PMID 10518219 DOI: 10.1016/S1097-2765(00)80340-8 |
0.532 |
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