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Catherine Freudenreich - Publications

Affiliations: 
Biology Tufts University, Boston 
Area:
Molecular Biology
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54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Polleys EJ, Del Priore I, Haber JE, Freudenreich CH. Structure-forming CAG/CTG repeats interfere with gap repair to cause repeat expansions and chromosome breaks. Nature Communications. 14: 2469. PMID 37120647 DOI: 10.1038/s41467-023-37901-2  0.527
2023 Wang ET, Freudenreich CH, Gromak N, Jain A, Todd PK, Nagai Y. What repeat expansion disorders can teach us about the Central Dogma. Molecular Cell. 83: 324-329. PMID 36736306 DOI: 10.1016/j.molcel.2022.12.017  0.316
2022 Brown RE, Su XA, Fair S, Wu K, Verra L, Jong R, Andrykovich K, Freudenreich CH. The RNA export and RNA decay complexes THO and TRAMP prevent transcription-replication conflicts, DNA breaks, and CAG repeat contractions. Plos Biology. 20: e3001940. PMID 36574440 DOI: 10.1371/journal.pbio.3001940  0.362
2021 Spivakovsky-Gonzalez E, Polleys EJ, Masnovo C, Cebrian J, Molina-Vargas AM, Freudenreich CH, Mirkin SM. Rad9-mediated checkpoint activation is responsible for elevated expansions of GAA repeats in CST-deficient yeast. Genetics. 219. PMID 34849883 DOI: 10.1093/genetics/iyab125  0.433
2021 Gold MA, Whalen JM, Freon K, Hong Z, Iraqui I, Lambert SAE, Freudenreich CH. Restarted replication forks are error-prone and cause CAG repeat expansions and contractions. Plos Genetics. 17: e1009863. PMID 34673780 DOI: 10.1371/journal.pgen.1009863  0.583
2021 Polleys EJ, Freudenreich CH. Homologous recombination within repetitive DNA. Current Opinion in Genetics & Development. 71: 143-153. PMID 34464817 DOI: 10.1016/j.gde.2021.08.005  0.554
2020 Brown RE, Freudenreich CH. Structure-forming repeats and their impact on genome stability. Current Opinion in Genetics & Development. 67: 41-51. PMID 33279816 DOI: 10.1016/j.gde.2020.10.006  0.509
2020 Kramarz K, Schirmeisen K, Boucherit V, Ait Saada A, Lovo C, Palancade B, Freudenreich C, Lambert SAE. The nuclear pore primes recombination-dependent DNA synthesis at arrested forks by promoting SUMO removal. Nature Communications. 11: 5643. PMID 33159083 DOI: 10.1038/s41467-020-19516-z  0.528
2020 van Wietmarschen N, Sridharan S, Nathan WJ, Tubbs A, Chan EM, Callen E, Wu W, Belinky F, Tripathi V, Wong N, Foster K, Noorbakhsh J, Garimella K, Cruz-Migoni A, Sommers JA, ... ... Freudenreich CH, et al. Repeat expansions confer WRN dependence in microsatellite-unstable cancers. Nature. PMID 32999459 DOI: 10.1038/s41586-020-2769-8  0.523
2020 Freudenreich CH. A Timeless Tale: G4 structure recognition by the fork protection complex triggers unwinding by DDX11 helicase. The Embo Journal. e106305. PMID 32790898 DOI: 10.15252/embj.2020106305  0.388
2020 Laverde EE, Lai Y, Leng F, Balakrishnan L, Freudenreich CH, Liu Y. R-loops promote trinucleotide repeat deletion through DNA base excision repair enzymatic activities. The Journal of Biological Chemistry. PMID 32763971 DOI: 10.1074/jbc.RA120.014161  0.365
2020 Whalen JM, Freudenreich CH. Location, Location, Location: The Role of Nuclear Positioning in the Repair of Collapsed Forks and Protection of Genome Stability. Genes. 11. PMID 32526925 DOI: 10.3390/genes11060635  0.526
2020 Whalen JM, Dhingra N, Wei L, Zhao X, Freudenreich CH. Relocation of Collapsed Forks to the Nuclear Pore Complex Depends on Sumoylation of DNA Repair Proteins and Permits Rad51 Association. Cell Reports. 31: 107635. PMID 32402281 DOI: 10.1016/J.Celrep.2020.107635  0.52
2020 Aguilera P, Whalen J, Minguet C, Churikov D, Freudenreich C, Simon MN, Géli V. The nuclear pore complex prevents sister chromatid recombination during replicative senescence. Nature Communications. 11: 160. PMID 31919430 DOI: 10.1038/S41467-019-13979-5  0.606
2020 Polleys EJ, Freudenreich CH. Genetic Assays to Study Repeat Fragility in Saccharomyces cerevisiae. Methods in Molecular Biology (Clifton, N.J.). 2056: 83-101. PMID 31586342 DOI: 10.1007/978-1-4939-9784-8_5  0.45
2020 Sanders EA, Polleys EJ, Freudenreich CH. The role of D‐loop synthesis and progression in trinucleotide repeat stability via a break induced replication (BIR) model. The Faseb Journal. 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.09880  0.343
2020 Johnson M, Whalen J, Freudenreich C. The Role of The DNA Damage Checkpoint in The Relocalization of CAG Trinucleotide Repeats to The Nuclear Pore Complex During S‐phase The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.09028  0.513
2019 House NC, Polleys EJ, Quasem I, De la Rosa Mejia M, Joyce CE, Takacsi-Nagy O, Krebs JE, Fuchs SM, Freudenreich CH. Distinct roles for H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126. Elife. 8. PMID 31804179 DOI: 10.7554/Elife.53362  0.395
2019 Kaushal S, Wollmuth CE, Das K, Hile SE, Regan SB, Barnes RP, Haouzi A, Lee SM, House NCM, Guyumdzhyan M, Eckert KA, Freudenreich CH. Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D. Cell Reports. 27: 1151-1164.e5. PMID 31018130 DOI: 10.1016/J.Celrep.2019.03.103  0.503
2019 Klein HL, Bačinskaja G, Che J, Cheblal A, Elango R, Epshtein A, Fitzgerald DM, Gómez-González B, Khan SR, Kumar S, Leland BA, Marie L, Mei Q, Miné-Hattab J, Piotrowska A, ... ... Freudenreich CH, et al. Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways. Microbial Cell (Graz, Austria). 6: 1-64. PMID 30652105 DOI: 10.15698/Mic2019.01.664  0.343
2018 Kaushal S, Freudenreich CH. The role of fork stalling and DNA structures in causing chromosome fragility. Genes, Chromosomes & Cancer. PMID 30536896 DOI: 10.1002/gcc.22721  0.569
2018 Gellon L, Kaushal S, Cebrián J, Lahiri M, Mirkin SM, Freudenreich CH. Mrc1 and Tof1 prevent fragility and instability at long CAG repeats by their fork stabilizing function. Nucleic Acids Research. PMID 30476303 DOI: 10.1093/nar/gky1195  0.579
2018 Zhao J, Wang G, Del Mundo IM, McKinney JA, Lu X, Bacolla A, Boulware SB, Zhang C, Zhang H, Ren P, Freudenreich CH, Vasquez KM. Distinct Mechanisms of Nuclease-Directed DNA-Structure-Induced Genetic Instability in Cancer Genomes. Cell Reports. 22: 1200-1210. PMID 29386108 DOI: 10.1016/J.Celrep.2018.01.014  0.674
2018 Freudenreich CH. R-loops: targets for nuclease cleavage and repeat instability. Current Genetics. PMID 29327083 DOI: 10.1007/s00294-018-0806-z  0.404
2018 Koch MR, House NCM, Cosetta CM, Jong RM, Salomon CG, Joyce CE, Philips EA, Su XA, Freudenreich CH. The Chromatin Remodeler Isw1 Prevents CAG Repeat Expansions During Transcription in Saccharomyces cerevisiae. Genetics. PMID 29305386 DOI: 10.1534/Genetics.117.300529  0.52
2018 Polleys EJ, Freudenreich CH. Methods to Study Repeat Fragility and Instability in Saccharomyces cerevisiae. Methods in Molecular Biology (Clifton, N.J.). 1672: 403-419. PMID 29043639 DOI: 10.1007/978-1-4939-7306-4_28  0.488
2017 Su XA, Freudenreich CH. Cytosine deamination and base excision repair cause R-loop-induced CAG repeat fragility and instability in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. PMID 28923949 DOI: 10.1073/pnas.1711283114  0.452
2017 Polleys EJ, House NCM, Freudenreich CH. Role of recombination and replication fork restart in repeat instability. Dna Repair. PMID 28641941 DOI: 10.1016/j.dnarep.2017.06.018  0.609
2017 Nguyen JH, Viterbo D, Anand RP, Verra L, Sloan L, Richard GF, Freudenreich CH. Differential requirement of Srs2 helicase and Rad51 displacement activities in replication of hairpin-forming CAG/CTG repeats. Nucleic Acids Research. PMID 28175398 DOI: 10.1093/Nar/Gkx088  0.711
2016 Freudenreich CH, Su XA. Relocalization of DNA Lesions to the Nuclear Pore Complex. Fems Yeast Research. PMID 27799300 DOI: 10.1093/femsyr/fow095  0.451
2015 Su XA, Dion V, Gasser SM, Freudenreich CH. Regulation of recombination at yeast nuclear pores controls repair and triplet repeat stability. Genes & Development. 29: 1006-17. PMID 25940904 DOI: 10.1101/gad.256404.114  0.594
2015 Usdin K, House NC, Freudenreich CH. Repeat instability during DNA repair: Insights from model systems. Critical Reviews in Biochemistry and Molecular Biology. 50: 142-67. PMID 25608779 DOI: 10.3109/10409238.2014.999192  0.448
2014 House NC, Koch MR, Freudenreich CH. Chromatin modifications and DNA repair: beyond double-strand breaks. Frontiers in Genetics. 5: 296. PMID 25250043 DOI: 10.3389/fgene.2014.00296  0.464
2014 House NC, Yang JH, Walsh SC, Moy JM, Freudenreich CH. NuA4 initiates dynamic histone H4 acetylation to promote high-fidelity sister chromatid recombination at postreplication gaps. Molecular Cell. 55: 818-28. PMID 25132173 DOI: 10.1016/j.molcel.2014.07.007  0.642
2014 Frizzell A, Nguyen JH, Petalcorin MI, Turner KD, Boulton SJ, Freudenreich CH, Lahue RS. RTEL1 inhibits trinucleotide repeat expansions and fragility. Cell Reports. 6: 827-35. PMID 24561255 DOI: 10.1016/J.Celrep.2014.01.034  0.443
2012 Anand RP, Shah KA, Niu H, Sung P, Mirkin SM, Freudenreich CH. Overcoming natural replication barriers: differential helicase requirements. Nucleic Acids Research. 40: 1091-105. PMID 21984413 DOI: 10.1093/Nar/Gkr836  0.701
2011 Sundararajan R, Freudenreich CH. Expanded CAG/CTG repeat DNA induces a checkpoint response that impacts cell proliferation in Saccharomyces cerevisiae. Plos Genetics. 7: e1001339. PMID 21437275 DOI: 10.1371/Journal.Pgen.1001339  0.545
2011 Gellon L, Razidlo DF, Gleeson O, Verra L, Schulz D, Lahue RS, Freudenreich CH. New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion. Plos Genetics. 7: e1001298. PMID 21347277 DOI: 10.1371/Journal.Pgen.1001298  0.585
2011 Cherng N, Shishkin AA, Schlager LI, Tuck RH, Sloan L, Matera R, Sarkar PS, Ashizawa T, Freudenreich CH, Mirkin SM. Expansions, contractions, and fragility of the spinocerebellar ataxia type 10 pentanucleotide repeat in yeast. Proceedings of the National Academy of Sciences of the United States of America. 108: 2843-8. PMID 21282659 DOI: 10.1073/Pnas.1009409108  0.463
2010 Yang JH, Freudenreich CH. The Rtt109 histone acetyltransferase facilitates error-free replication to prevent CAG/CTG repeat contractions Dna Repair. 9: 414-420. PMID 20083442 DOI: 10.1016/j.dnarep.2009.12.022  0.638
2010 Sundararajan R, Gellon L, Zunder RM, Freudenreich CH. Double-strand break repair pathways protect against CAG/CTG repeat expansions, contractions and repeat-mediated chromosomal fragility in Saccharomyces cerevisiae. Genetics. 184: 65-77. PMID 19901069 DOI: 10.1534/Genetics.109.111039  0.55
2009 Voineagu I, Freudenreich CH, Mirkin SM. Checkpoint responses to unusual structures formed by DNA repeats. Molecular Carcinogenesis. 48: 309-18. PMID 19306277 DOI: 10.1002/mc.20512  0.556
2009 Kerrest A, Anand RP, Sundararajan R, Bermejo R, Liberi G, Dujon B, Freudenreich CH, Richard GF. SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination. Nature Structural & Molecular Biology. 16: 159-67. PMID 19136956 DOI: 10.1038/Nsmb.1544  0.702
2007 Zhang H, Freudenreich CH. An AT-rich sequence in human common fragile site FRA16D causes fork stalling and chromosome breakage in S. cerevisiae. Molecular Cell. 27: 367-79. PMID 17679088 DOI: 10.1016/J.Molcel.2007.06.012  0.648
2007 Freudenreich CH. Chromosome fragility: molecular mechanisms and cellular consequences. Frontiers in Bioscience : a Journal and Virtual Library. 12: 4911-24. PMID 17569619  0.458
2007 Yang J, Freudenreich CH. Haploinsufficiency of yeast FEN1 causes instability of expanded CAG/CTG tracts in a length-dependent manner. Gene. 393: 110-5. PMID 17383831 DOI: 10.1016/j.gene.2007.01.025  0.618
2004 Freudenreich CH, Lahiri M. Structure-forming CAG/CTG repeat sequences are sensitive to breakage in the absence of Mrc1 checkpoint function and S-phase checkpoint signaling: implications for trinucleotide repeat expansion diseases. Cell Cycle (Georgetown, Tex.). 3: 1370-4. PMID 15483399  0.499
2004 Lahiri M, Gustafson TL, Majors ER, Freudenreich CH. Expanded CAG repeats activate the DNA damage checkpoint pathway. Molecular Cell. 15: 287-93. PMID 15260979 DOI: 10.1016/j.molcel.2004.06.034  0.567
2004 Liu Y, Zhang H, Veeraraghavan J, Bambara RA, Freudenreich CH. Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability. Molecular and Cellular Biology. 24: 4049-64. PMID 15082797 DOI: 10.1128/Mcb.24.9.4049-4064.2004  0.624
2004 Lenzmeier BA, Freudenreich CH. Trinucleotide repeat instability: a hairpin curve at the crossroads of replication, recombination, and repair. Cytogenetic and Genome Research. 100: 7-24. PMID 14526162 DOI: 10.1159/000072836  0.427
2003 Callahan JL, Andrews KJ, Zakian VA, Freudenreich CH. Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility. Molecular and Cellular Biology. 23: 7849-60. PMID 14560028 DOI: 10.1128/Mcb.23.21.7849-7860.2003  0.558
2000 Balakumaran BS, Freudenreich CH, Zakian VA. CGG/CCG repeats exhibit orientation-dependent instability and orientation-independent fragility in Saccharomyces cerevisiae. Human Molecular Genetics. 9: 93-100. PMID 10587583 DOI: 10.1093/Hmg/9.1.93  0.388
1998 Freudenreich CH, Kantrow SM, Zakian VA. Expansion and length-dependent fragility of CTG repeats in yeast. Science (New York, N.Y.). 279: 853-6. PMID 9452383 DOI: 10.1126/Science.279.5352.853  0.427
1997 Freudenreich CH, Stavenhagen JB, Zakian VA. Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome. Molecular and Cellular Biology. 17: 2090-8. PMID 9121457 DOI: 10.1128/Mcb.17.4.2090  0.405
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