| Year |
Citation |
Score |
| 2016 |
Cheng D, Liu J, Han D, Zhang G, Gao W, Hsieh MH, Ng N, Kasibhatla S, Tompkins C, Li J, Steffy A, Sun F, Li C, Seidel HM, Harris JL, et al. Discovery of Pyridinyl Acetamide Derivatives as Potent, Selective, and Orally Bioavailable Porcupine Inhibitors. Acs Medicinal Chemistry Letters. 7: 676-80. PMID 27437076 DOI: 10.1021/Acsmedchemlett.6B00038 |
0.382 |
|
| 2016 |
Jia Y, Yun CH, Park E, Ercan D, Manuia M, Juarez J, Xu C, Rhee K, Chen T, Zhang H, Palakurthi S, Jang J, Lelais G, DiDonato M, Bursulaya B, ... ... Harris J, et al. Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature. 534: 129-32. PMID 27251290 DOI: 10.1038/Nature17960 |
0.311 |
|
| 2016 |
Jia Y, Juarez J, Li J, Manuia M, Niederst MJ, Tompkins C, Timple N, Vaillancourt MT, Culazzo Pferdekamper A, Lockerman EL, Li C, Anderson J, Costa C, Liao D, Murphy E, ... ... Harris J, et al. EGF816 exerts anticancer effects in non-small cell lung cancer by irreversibly and selectively targeting primary and acquired activating mutations in the EGF receptor. Cancer Research. PMID 26825170 DOI: 10.1158/0008-5472.Can-15-2581 |
0.308 |
|
| 2016 |
Pan S, Liu J, Cheng D, Han D, Zhang G, Hsieh M, Ng N, Li C, Kasibhatla S, McNamara P, Seidel HM, Harris J. Abstract IA35: Discovery of porcupine inhibitors targeting Wnt signaling in cancer Cancer Research. 76. DOI: 10.1158/1538-7445.Fbcr15-Ia35 |
0.337 |
|
| 2015 |
Choi HS, Rucker PV, Wang Z, Fan Y, Albaugh P, Chopiuk G, Gessier F, Sun F, Adrian F, Liu G, Hood T, Li N, Jia Y, Che J, McCormack S, ... ... Harris J, et al. (R)-2-Phenylpyrrolidine Substituted Imidazopyridazines: A New Class of Potent and Selective Pan-TRK Inhibitors. Acs Medicinal Chemistry Letters. 6: 562-7. PMID 26005534 DOI: 10.1021/Acsmedchemlett.5B00050 |
0.34 |
|
| 2013 |
Liu J, Pan S, Hsieh MH, Ng N, Sun F, Wang T, Kasibhatla S, Schuller AG, Li AG, Cheng D, Li J, Tompkins C, Pferdekamper A, Steffy A, Cheng J, ... ... Harris JL, et al. Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proceedings of the National Academy of Sciences of the United States of America. 110: 20224-9. PMID 24277854 DOI: 10.1073/Pnas.1314239110 |
0.344 |
|
| 2013 |
Marsilje TH, Pei W, Chen B, Lu W, Uno T, Jin Y, Jiang T, Kim S, Li N, Warmuth M, Sarkisova Y, Sun F, Steffy A, Pferdekamper AC, Li AG, ... ... Harris JL, et al. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials. Journal of Medicinal Chemistry. 56: 5675-90. PMID 23742252 DOI: 10.1021/Jm400402Q |
0.322 |
|
| 2012 |
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, Reddy A, Liu M, Murray L, Berger MF, Monahan JE, ... ... Harris JL, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 483: 603-7. PMID 22460905 DOI: 10.1038/Nature11003 |
0.306 |
|
| 2011 |
Alves J, Westling L, Peters EC, Harris JL, Trauger JW. Cloning, expression, and enzymatic activity of Acinetobacter baumannii and Klebsiella pneumoniae acetyl-coenzyme A carboxylases. Analytical Biochemistry. 417: 103-11. PMID 21704013 DOI: 10.1016/J.Ab.2011.05.041 |
0.331 |
|
| 2011 |
Liu J, Pan S, Sun F, Kasibhatla S, Schuller A, Li A, Li C, Cui X, Wang T, Villarroel M, Mclaughlin M, Sellers W, Boral A, Harris J. PD08-11: Targeting Porcupine, a Critical Node for Wnt Signalling in Cancer. Cancer Research. 71. DOI: 10.1158/0008-5472.Sabcs11-Pd08-11 |
0.345 |
|
| 2010 |
Lee CC, Jia Y, Li N, Sun X, Ng K, Ambing E, Gao MY, Hua S, Chen C, Kim S, Michellys PY, Lesley SA, Harris JL, Spraggon G. Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain. The Biochemical Journal. 430: 425-37. PMID 20632993 DOI: 10.1042/Bj20100609 |
0.302 |
|
| 2010 |
Gonzalez R, Jennings LL, Knuth M, Orth AP, Klock HE, Ou W, Feuerhelm J, Hull MV, Koesema E, Wang Y, Zhang J, Wu C, Cho CY, Su AI, Batalov S, ... ... Harris JL, et al. Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency. Proceedings of the National Academy of Sciences of the United States of America. 107: 3552-7. PMID 20133595 DOI: 10.1073/Pnas.0914019107 |
0.338 |
|
| 2010 |
Owen KA, Qiu D, Alves J, Schumacher AM, Kilpatrick LM, Li J, Harris JL, Ellis V. Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA. The Biochemical Journal. 426: 219-28. PMID 20015050 DOI: 10.1042/Bj20091448 |
0.353 |
|
| 2010 |
Barretina J, Caponigro G, Kim S, Stransky N, Venkhatesan K, Reddy V, Berger M, Morrissey M, Morais P, Meltzer J, Thibault J, Mahan S, Sonkin D, Che J, Raman P, ... ... Harris J, et al. Abstract 2620: The Cancer Cell Line Encyclopedia project: From integrative cancer genomics to personalized cancer therapy Cancer Research. 70: 2620-2620. DOI: 10.1158/1538-7445.Am10-2620 |
0.312 |
|
| 2010 |
Stransky N, Venkhatesan K, Morrissey M, Barretina J, Raman P, Getz G, Berger M, Johannessen C, Callahan A, Morais P, Mahan S, Gupta S, Onofrio R, Sougnez C, Winckler W, ... ... Harris J, et al. Abstract 105: Integrative analysis of genomic and pharmacologic data from the Cancer Cell Line Encyclopedia Cancer Research. 70: 105-105. DOI: 10.1158/1538-7445.Am10-105 |
0.305 |
|
| 2009 |
Alves J, Wurdak H, Garay-Malpartida HM, Harris JL, Occhiucci JM, Belizário JE, Li J. TAF15 and the leukemia-associated fusion protein TAF15-CIZ/NMP4 are cleaved by caspases-3 and -7. Biochemical and Biophysical Research Communications. 384: 495-500. PMID 19426707 DOI: 10.1016/J.Bbrc.2009.05.009 |
0.308 |
|
| 2009 |
Li J, Petrassi HM, Tumanut C, Masick BT, Trussell C, Harris JL. Substrate optimization for monitoring cathepsin C activity in live cells. Bioorganic & Medicinal Chemistry. 17: 1064-70. PMID 18313933 DOI: 10.1016/J.Bmc.2008.02.002 |
0.327 |
|
| 2008 |
Tully DC, Vidal A, Chatterjee AK, Williams JA, Roberts MJ, Petrassi HM, Spraggon G, Bursulaya B, Pacoma R, Shipway A, Schumacher AM, Danahay H, Harris JL. Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design. Bioorganic & Medicinal Chemistry Letters. 18: 5895-9. PMID 18752942 DOI: 10.1016/J.Bmcl.2008.08.029 |
0.33 |
|
| 2007 |
Borgoño CA, Gavigan JA, Alves J, Bowles B, Harris JL, Sotiropoulou G, Diamandis EP. Defining the extended substrate specificity of kallikrein 1-related peptidases. Biological Chemistry. 388: 1215-25. PMID 17976015 DOI: 10.1515/Bc.2007.124 |
0.349 |
|
| 2007 |
Chatterjee AK, Liu H, Tully DC, Guo J, Epple R, Russo R, Williams J, Roberts M, Tuntland T, Chang J, Gordon P, Hollenbeck T, Tumanut C, Li J, Harris JL. Synthesis and SAR of succinamide peptidomimetic inhibitors of cathepsin S. Bioorganic & Medicinal Chemistry Letters. 17: 2899-903. PMID 17382545 DOI: 10.1016/J.Bmcl.2007.02.049 |
0.343 |
|
| 2007 |
Epple R, Urbina HD, Russo R, Liu H, Mason D, Bursulaya B, Tumanut C, Li J, Harris JL. Bicyclic carbamates as inhibitors of papain-like cathepsin proteases. Bioorganic & Medicinal Chemistry Letters. 17: 1254-9. PMID 17196818 DOI: 10.1016/J.Bmcl.2006.12.014 |
0.335 |
|
| 2006 |
Vercammen D, Belenghi B, van de Cotte B, Beunens T, Gavigan JA, De Rycke R, Brackenier A, Inzé D, Harris JL, Van Breusegem F. Serpin1 of Arabidopsis thaliana is a suicide inhibitor for metacaspase 9. Journal of Molecular Biology. 364: 625-36. PMID 17028019 DOI: 10.1016/J.Jmb.2006.09.010 |
0.356 |
|
| 2006 |
Urbina HD, Debaene F, Jost B, Bole-Feysot C, Mason DE, Kuzmic P, Harris JL, Winssinger N. Self-assembled small-molecule microarrays for protease screening and profiling. Chembiochem : a European Journal of Chemical Biology. 7: 1790-7. PMID 17009273 DOI: 10.1002/Cbic.200600242 |
0.569 |
|
| 2006 |
Tully DC, Liu H, Chatterjee AK, Alper PB, Williams JA, Roberts MJ, Mutnick D, Woodmansee DH, Hollenbeck T, Gordon P, Chang J, Tuntland T, Tumanut C, Li J, Harris JL, et al. Arylaminoethyl carbamates as a novel series of potent and selective cathepsin S inhibitors. Bioorganic & Medicinal Chemistry Letters. 16: 5107-11. PMID 16876407 DOI: 10.1016/J.Bmcl.2006.07.032 |
0.354 |
|
| 2006 |
Tully DC, Liu H, Chatterjee AK, Alper PB, Epple R, Williams JA, Roberts MJ, Woodmansee DH, Masick BT, Tumanut C, Li J, Spraggon G, Hornsby M, Chang J, Tuntland T, ... ... Harris JL, et al. Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers. Bioorganic & Medicinal Chemistry Letters. 16: 5112-7. PMID 16876402 DOI: 10.1016/J.Bmcl.2006.07.033 |
0.311 |
|
| 2006 |
Xia W, Bacus S, Hegde P, Husain I, Strum J, Liu L, Paulazzo G, Lyass L, Trusk P, Hill J, Harris J, Spector NL. A model of acquired autoresistance to a potent ErbB2 tyrosine kinase inhibitor and a therapeutic strategy to prevent its onset in breast cancer Proceedings of the National Academy of Sciences of the United States of America. 103: 7795-7800. PMID 16682622 DOI: 10.1073/Pnas.0602468103 |
0.31 |
|
| 2006 |
Tully DC, Liu H, Alper PB, Chatterjee AK, Epple R, Roberts MJ, Williams JA, Nguyen KT, Woodmansee DH, Tumanut C, Li J, Spraggon G, Chang J, Tuntland T, Harris JL, et al. Synthesis and evaluation of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 3: heterocyclic P3. Bioorganic & Medicinal Chemistry Letters. 16: 1975-80. PMID 16446091 DOI: 10.1016/J.Bmcl.2005.12.095 |
0.314 |
|
| 2006 |
Alper PB, Liu H, Chatterjee AK, Nguyen KT, Tully DC, Tumanut C, Li J, Harris JL, Tuntland T, Chang J, Gordon P, Hollenbeck T, Karanewsky DS. Arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 2: Optimization of P1 and N-aryl. Bioorganic & Medicinal Chemistry Letters. 16: 1486-90. PMID 16412634 DOI: 10.1016/J.Bmcl.2005.12.056 |
0.327 |
|
| 2006 |
Xia W, Bacus S, Hedge P, Husain I, Strum J, Liu L, Paulazzo G, Harris J, Trusk P, Spector N. Autoresistance to ErbB2 kinase inhibitors: Elucidating mechanisms and identfying strategies to prevent its onset in breast cancer Journal of Clinical Oncology. 24: 2075-2075. DOI: 10.1200/Jco.2006.24.18_Suppl.2075 |
0.316 |
|
| 2005 |
Winssinger N, Harris JL. Microarray-based functional protein profiling using peptide nucleic acid-encoded libraries. Expert Review of Proteomics. 2: 937-47. PMID 16307522 DOI: 10.1586/14789450.2.6.937 |
0.573 |
|
| 2005 |
Liu H, Tully DC, Epple R, Bursulaya B, Li J, Harris JL, Williams JA, Russo R, Tumanut C, Roberts MJ, Alper PB, He Y, Karanewsky DS. Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1. Bioorganic & Medicinal Chemistry Letters. 15: 4979-84. PMID 16183279 DOI: 10.1016/J.Bmcl.2005.08.017 |
0.315 |
|
| 2005 |
Harris JL, Winssinger N. PNA encoding (PNA=peptide nucleic acid): from solution-based libraries to organized microarrays. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 6792-801. PMID 16038006 DOI: 10.1002/Chem.200500305 |
0.552 |
|
| 2005 |
Li J, Lim SP, Beer D, Patel V, Wen D, Tumanut C, Tully DC, Williams JA, Jiricek J, Priestle JP, Harris JL, Vasudevan SG. Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries. The Journal of Biological Chemistry. 280: 28766-74. PMID 15932883 DOI: 10.1074/Jbc.M500588200 |
0.307 |
|
| 2005 |
Petrassi HM, Williams JA, Li J, Tumanut C, Ek J, Nakai T, Masick B, Backes BJ, Harris JL. A strategy to profile prime and non-prime proteolytic substrate specificity. Bioorganic & Medicinal Chemistry Letters. 15: 3162-6. PMID 15878267 DOI: 10.1016/J.Bmcl.2005.04.019 |
0.303 |
|
| 2004 |
Dees EC, Burris H, Hurwitz H, Dowlati A, Smith D, Koch K, Stead A, Mangum S, Harris J, Spector N. Clinical summary of 67 heavily pre-treated patients with metastatic carcinomas treated with GW572016 in a phase Ib study. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 22: 3188. PMID 28015923 DOI: 10.1200/Jco.2004.22.14_Suppl.3188 |
0.311 |
|
| 2004 |
Harris J, Mason DE, Li J, Burdick KW, Backes BJ, Chen T, Shipway A, Van Heeke G, Gough L, Ghaemmaghami A, Shakib F, Debaene F, Winssinger N. Activity profile of dust mite allergen extract using substrate libraries and functional proteomic microarrays. Chemistry & Biology. 11: 1361-72. PMID 15489163 DOI: 10.1016/J.Chembiol.2004.08.008 |
0.569 |
|
| 2004 |
Winssinger N, Damoiseaux R, Tully DC, Geierstanger BH, Burdick K, Harris JL. PNA-encoded protease substrate microarrays. Chemistry & Biology. 11: 1351-60. PMID 15489162 DOI: 10.1016/J.Chembiol.2004.07.015 |
0.562 |
|
| 2004 |
Shipway A, Danahay H, Williams JA, Tully DC, Backes BJ, Harris JL. Biochemical characterization of prostasin, a channel activating protease. Biochemical and Biophysical Research Communications. 324: 953-63. PMID 15474520 DOI: 10.1016/J.Bbrc.2004.09.123 |
0.324 |
|
| 2004 |
Mason DE, Ek J, Peters EC, Harris JL. Substrate profiling of deubiquitin hydrolases with a positional scanning library and mass spectrometry. Biochemistry. 43: 6535-44. PMID 15157086 DOI: 10.1021/Bi049722J |
0.339 |
|
| 2004 |
Debaene F, Mejias L, Harris JL, Winssinger N. Synthesis of a PNA-encoded cysteine protease inhibitor library Tetrahedron. 60: 8677-8690. DOI: 10.1016/J.Tet.2004.05.107 |
0.562 |
|
| 2002 |
Winssinger N, Ficarro S, Schultz PG, Harris JL. Profiling protein function with small molecule microarrays. Proceedings of the National Academy of Sciences of the United States of America. 99: 11139-44. PMID 12167675 DOI: 10.1073/Pnas.172286899 |
0.565 |
|
| 2001 |
Winssinger N, Harris JL, Backes BJ, Schultz PG. From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling. Angewandte Chemie (International Ed. in English). 40: 3152-3155. PMID 29712061 DOI: 10.1002/1521-3773(20010903)40:17<3152::Aid-Anie3152>3.0.Co;2-P |
0.553 |
|
| 2001 |
Winssinger N, Harris JL, Backes BJ, Schultz PG. From split-pool libraries to spatially addressable microarrays and its application to functional proteomic profiling Angewandte Chemie - International Edition. 40: 3152-3155. DOI: 10.1002/1521-3773(20010903)40:17<3152::AID-ANIE3152>3.0.CO;2-P |
0.464 |
|
| 2001 |
Winssinger N, Harris JL, Backes BJ, Schultz PG. Cover Picture Angewandte Chemie International Edition. 40: 3083-3083. DOI: 10.1002/1521-3773(20010903)40:17<3083::AID-ANIE3083>3.0.CO;2-J |
0.4 |
|
| 2001 |
Winssinger N, Harris JL, Backes BJ, Schultz PG. Von Split-Pool-Molekülbibliotheken zu räumlich adressierbaren Mikro-Arrays und deren Einsatz in der funktionellen Proteomik Angewandte Chemie. 113: 3254-3258. DOI: 10.1002/1521-3757(20010903)113:17<3254::Aid-Ange3254>3.0.Co;2-9 |
0.484 |
|
| 2000 |
Backes BJ, Harris JL, Leonetti F, Craik CS, Ellman JA. Erratum: Erratum to “Synthesis of positional-scanning libraries of fluorogenic peptide substrates to define the extended substrate specificity of plasmin and thrombin” Nature Biotechnology. 18: 559-559. DOI: 10.1038/75441 |
0.301 |
|
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