| Year |
Citation |
Score |
| 2018 |
Hansen R, Peters U, Babbar A, Chen Y, Feng J, Janes MR, Li LS, Ren P, Liu Y, Zarrinkar PP. The reactivity-driven biochemical mechanism of covalent KRAS inhibitors. Nature Structural & Molecular Biology. PMID 29760531 DOI: 10.1038/S41594-018-0061-5 |
0.553 |
|
| 2018 |
Janes MR, Zhang J, Li LS, Hansen R, Peters U, Guo X, Chen Y, Babbar A, Firdaus SJ, Darjania L, Feng J, Chen JH, Li S, Li S, Long YO, et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell. 172: 578-589.e17. PMID 29373830 DOI: 10.1016/J.Cell.2018.01.006 |
0.51 |
|
| 2018 |
Li L, Janes MR, Zhang J, Hansen R, Peters U, Guo X, Chen Y, Babbar A, Firdaus SJ, Feng J, Chen JH, Li S, Li S, Thach C, Liu Y, et al. Abstract 929: Discovery of novel covalent KRASG12C inhibitors that display high potency and selectivity in vitro and in vivo Cancer Research. 78: 929-929. DOI: 10.1158/1538-7445.Am2018-929 |
0.546 |
|
| 2018 |
Hansen R, Peters U, Babbar A, Chen Y, Feng J, Janes MR, Li L, Ren P, Liu Y, Zarrinkar PP. Abstract 686: Drugging an undruggable pocket: The biochemical mechanism of covalent KRASG12C inhibitors Cancer Research. 78: 686-686. DOI: 10.1158/1538-7445.Am2018-686 |
0.566 |
|
| 2018 |
Burrows FJ, Kessler L, Wu T, Gao X, Chen J, Hansen R, Li S, Thach C, Li S, Yu K, Kucharski J, Peters U, Feng J, Wang Y, Yao Y, et al. Abstract 3885: 11q13 amplification selects for sensitivity to the ERK inhibitor KO-947 in squamous cell carcinomas Cancer Research. 78: 3885-3885. DOI: 10.1158/1538-7445.Am2018-3885 |
0.41 |
|
| 2017 |
Wu T, Kessler L, Li S, Purohit T, Li S, Miao H, Linhares B, Hansen R, Kucharski J, Wang Y, Yu K, Kempinska K, Ely T, Klossowski S, Zarieh A, ... Peters U, et al. Abstract 5077: A novel small molecule menin-MLL inhibitor for potential treatment of MLL-rearranged leukemias Cancer Research. 77: 5077-5077. DOI: 10.1158/1538-7445.Am2017-5077 |
0.456 |
|
| 2016 |
Patricelli MP, Janes MR, Li LS, Hansen R, Peters U, Kessler LV, Chen Y, Kucharski JM, Feng J, Ely T, Chen JH, Firdaus SJ, Babbar A, Ren P, Liu Y. Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State. Cancer Discovery. PMID 26739882 DOI: 10.1158/2159-8290.Cd-15-1105 |
0.543 |
|
| 2014 |
Kashyap S, Sandler J, Peters U, Martinez EJ, Kapoor TM. Using 'biased-privileged' scaffolds to identify lysine methyltransferase inhibitors. Bioorganic & Medicinal Chemistry. 22: 2253-60. PMID 24650704 DOI: 10.1016/J.Bmc.2014.02.024 |
0.412 |
|
| 2013 |
Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 503: 548-51. PMID 24256730 DOI: 10.1038/Nature12796 |
0.697 |
|
| 2013 |
Lopez MS, Choy JW, Peters U, Sos ML, Morgan DO, Shokat KM. Staurosporine-derived inhibitors broaden the scope of analog-sensitive kinase technology. Journal of the American Chemical Society. 135: 18153-9. PMID 24171479 DOI: 10.1021/Ja408704U |
0.715 |
|
| 2013 |
Ostrem JM, Peters U, Ren P, Liu Y, Wells JA, Shokat KM. Abstract LB-311: Development of mutant-specific small molecule inhibitors of K-Ras. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-311 |
0.748 |
|
| 2013 |
Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. Abstract PL04-03: Selective inhibition of K-Ras G12C through allosteric control of GTP affinity and effector interactions. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-Pl04-03 |
0.751 |
|
| 2011 |
Garske AL, Peters U, Cortesi AT, Perez JL, Shokat KM. Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Proceedings of the National Academy of Sciences of the United States of America. 108: 15046-52. PMID 21852571 DOI: 10.1073/Pnas.1111239108 |
0.692 |
|
| 2007 |
Brennan IM, Peters U, Kapoor TM, Straight AF. Polo-like kinase controls vertebrate spindle elongation and cytokinesis. Plos One. 2: e409. PMID 17476331 DOI: 10.1371/Journal.Pone.0000409 |
0.333 |
|
| 2006 |
Peters U, Cherian J, Kim JH, Kwok BH, Kapoor TM. Probing cell-division phenotype space and Polo-like kinase function using small molecules. Nature Chemical Biology. 2: 618-26. PMID 17028580 DOI: 10.1038/Nchembio826 |
0.44 |
|
| 2005 |
Llauger L, He H, Kim J, Aguirre J, Rosen N, Peters U, Davies P, Chiosis G. Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90. Journal of Medicinal Chemistry. 48: 2892-905. PMID 15828828 DOI: 10.1021/Jm049012B |
0.419 |
|
| 2005 |
Marcus AI, Peters U, Thomas SL, Garrett S, Zelnak A, Kapoor TM, Giannakakou P. Mitotic kinesin inhibitors induce mitotic arrest and cell death in Taxol-resistant and -sensitive cancer cells. The Journal of Biological Chemistry. 280: 11569-77. PMID 15653676 DOI: 10.1074/Jbc.M413471200 |
0.362 |
|
| 2004 |
Peters U, Kapoor TM. New probes for microtubule dynamics. Chemistry & Biology. 11: 14-6. PMID 15112989 DOI: 10.1016/J.Chembiol.2004.01.003 |
0.346 |
|
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