Hui Zheng - Publications

Affiliations: 
Baylor College of Medicine, Houston, TX 
Area:
Alzheimer's Disease

93 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Roy ER, Chiu G, Li S, Propson NE, Kanchi R, Wang B, Coarfa C, Zheng H, Cao W. Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques. Immunity. PMID 35443157 DOI: 10.1016/j.immuni.2022.03.018  0.363
2021 Du S, Jin F, Maneix L, Gedam M, Xu Y, Catic A, Wang MC, Zheng H. FoxO3 deficiency in cortical astrocytes leads to impaired lipid metabolism and aggravated amyloid pathology. Aging Cell. e13432. PMID 34247441 DOI: 10.1111/acel.13432  0.399
2021 Xu Y, Propson NE, Du S, Xiong W, Zheng H. Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34187889 DOI: 10.1073/pnas.2023418118  0.305
2021 Chen F, Swartzlander DB, Ghosh A, Fryer JD, Wang B, Zheng H. Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer's disease neuropathology. Molecular Neurodegeneration. 16: 5. PMID 33517893 DOI: 10.1186/s13024-021-00426-7  0.775
2020 Ghosh A, Comerota MM, Wan D, Chen F, Propson NE, Hwang SH, Hammock BD, Zheng H. An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease. Science Translational Medicine. 12. PMID 33298560 DOI: 10.1126/scitranslmed.abb1206  0.369
2020 Wan YW, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, Swarup V, Funk CC, Gaiteri C, Allen M, Wang M, Neuner SM, Kaczorowski CC, Philip VM, Howell GR, ... ... Zheng H, et al. Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models. Cell Reports. 32: 107908. PMID 32668255 DOI: 10.1016/J.Celrep.2020.107908  0.351
2020 Xu Y, Du S, Marsh JA, Horie K, Sato C, Ballabio A, Karch CM, Holtzman DM, Zheng H. TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading. Molecular Psychiatry. PMID 32366951 DOI: 10.1038/S41380-020-0738-0  0.436
2020 Roy ER, Wang B, Wan YW, Chiu GS, Cole AL, Yin Z, Propson NE, Xu Y, Jankowsky JL, Liu Z, Lee VM, Trojanowski JQ, Ginsberg SD, Butovsky O, Zheng H, et al. Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease. The Journal of Clinical Investigation. PMID 31917687 DOI: 10.1172/Jci133737  0.803
2019 Roy E, Wang B, Zheng H, Cao W. TYPE I INTERFERON-MEDIATED NEUROINFLAMMATORY PROGRAM AND SYNAPSE LOSS IN ALZHEIMER’S DISEASE Innovation in Aging. 3: S92-S92. DOI: 10.1093/geroni/igz038.349  0.465
2019 Du S, Maneix L, Zhang Q, Wan Y, Zheng H. The Role Of Foxo3 Transcription Factor In Alzheimer’S Disease Pathology Innovation in Aging. 3. DOI: 10.1093/Geroni/Igz038.3102  0.313
2019 Propson NE, Litvinchuk A, Roy ER, Contreras B, Cao W, Zheng H. INCREASED C3 IN THE AGING BRAIN PROMOTES INFLAMMATORY TRANSITION IN ENDOTHELIAL CELLS Innovation in Aging. 3: S840-S840. DOI: 10.1093/geroni/igz038.3093  0.313
2018 Li H, Liu CC, Zheng H, Huang TY. Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer's disease -conformist, nonconformist, and realistic prospects for AD pathogenesis. Translational Neurodegeneration. 7: 34. PMID 30603085 DOI: 10.1186/s40035-018-0139-3  0.528
2018 Litvinchuk A, Wan YW, Swartzlander DB, Chen F, Cole A, Propson NE, Wang Q, Zhang B, Liu Z, Zheng H. Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease. Neuron. PMID 30415998 DOI: 10.1016/J.Neuron.2018.10.031  0.496
2018 Cao W, Zheng H. Peripheral immune system in aging and Alzheimer's disease. Molecular Neurodegeneration. 13: 51. PMID 30285785 DOI: 10.1186/s13024-018-0284-2  0.43
2018 Martini-Stoica H, Cole AL, Swartzlander DB, Chen F, Wan YW, Bajaj L, Bader DA, Lee VMY, Trojanowski JQ, Liu Z, Sardiello M, Zheng H. TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. The Journal of Experimental Medicine. PMID 30108137 DOI: 10.1084/Jem.20172158  0.48
2018 Pan G, Chen Z, Zheng H, Zhang Y, Xu H, Bu G, Zheng H, Li Y. Compensatory Mechanisms Modulate the Neuronal Excitability in a Kainic Acid-Induced Epilepsy Mouse Model. Frontiers in Neural Circuits. 12: 48. PMID 30008664 DOI: 10.3389/Fncir.2018.00048  0.305
2018 Swartzlander DB, Propson NE, Roy ER, Saito T, Saido T, Wang B, Zheng H. Concurrent cell type-specific isolation and profiling of mouse brains in inflammation and Alzheimer's disease. Jci Insight. 3. PMID 29997299 DOI: 10.1172/Jci.Insight.121109  0.74
2018 Dai MH, Zheng H, Zeng LD, Zhang Y. The genes associated with early-onset Alzheimer's disease. Oncotarget. 9: 15132-15143. PMID 29599933 DOI: 10.18632/oncotarget.23738  0.365
2017 Jankowsky JL, Zheng H. Practical considerations for choosing a mouse model of Alzheimer's disease. Molecular Neurodegeneration. 12: 89. PMID 29273078 DOI: 10.1186/s13024-017-0231-7  0.425
2017 Li Y, Chen Z, Gao Y, Pan G, Zheng H, Zhang Y, Xu H, Bu G, Zheng H. Synaptic adhesion molecule Pcdh-γC5 mediates synaptic dysfunction in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28842416 DOI: 10.1523/Jneurosci.1051-17.2017  0.459
2017 Wang B, Li H, Mutlu SA, Bowser DA, Moore MJ, Wang MC, Zheng H. The Amyloid Precursor Protein Is a Conserved Receptor for Slit to Mediate Axon Guidance. Eneuro. 4. PMID 28785723 DOI: 10.1523/ENEURO.0185-17.2017  0.799
2017 Chen M, Wang J, Jiang J, Zheng X, Justice NJ, Wang K, Li Y, Ran X, Huo Q, Zhang J, Li H, Lu N, Wang Y, Zheng H, Long C, et al. APP modulates KCC2 expression and function in hippocampal GABAergic inhibition. Elife. 6. PMID 28054918 DOI: 10.7554/Elife.20142  0.784
2017 Litvinchuk A, Wan Y, Cole A, Chen F, Liu Z, Zheng H. The Role Of Complement C3 And C3Ar Receptor In Tau Pathology In Alzheimer’S Disease Alzheimers & Dementia. 13: 229. DOI: 10.1016/J.Jalz.2017.07.115  0.339
2016 Xu Y, Martini-Stoica H, Zheng H. A seeding based cellular assay of tauopathy. Molecular Neurodegeneration. 11: 32. PMID 27112488 DOI: 10.1186/s13024-016-0100-9  0.371
2016 Martini-Stoica H, Xu Y, Ballabio A, Zheng H. The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective. Trends in Neurosciences. PMID 26968346 DOI: 10.1016/J.Tins.2016.02.002  0.373
2016 Li Y, Sun H, Chen Z, Xu H, Bu G, Zheng H. Implications of GABAergic Neurotransmission in Alzheimer's Disease. Frontiers in Aging Neuroscience. 8: 31. PMID 26941642 DOI: 10.3389/Fnagi.2016.00031  0.418
2016 Lian H, Litvinchuk A, Chiang AC, Aithmitti N, Jankowsky JL, Zheng H. Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 577-89. PMID 26758846 DOI: 10.1523/JNEUROSCI.2117-15.2016  0.489
2016 Chen M, Wang J, Jiang J, Zheng X, Justice NJ, Wang K, Ran X, Li Y, Huo Q, Zhang J, Li H, Lu N, Wang Y, Zheng H, Long C, et al. Author response: APP modulates KCC2 expression and function in hippocampal GABAergic inhibition Elife. DOI: 10.7554/Elife.20142.027  0.487
2015 Lian H, Zheng H. Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease. Journal of Neurochemistry. PMID 26546579 DOI: 10.1111/jnc.13424  0.4
2015 Justice NJ, Huang L, Tian JB, Cole A, Pruski M, Hunt AJ, Flores R, Zhu MX, Arenkiel BR, Zheng H. Posttraumatic stress disorder-like induction elevates β-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2612-23. PMID 25673853 DOI: 10.1523/Jneurosci.3333-14.2015  0.715
2015 Lian H, Yang L, Cole A, Sun L, Chiang AC, Fowler SW, Shim DJ, Rodriguez-Rivera J, Taglialatela G, Jankowsky JL, Lu HC, Zheng H. NFκB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease. Neuron. 85: 101-15. PMID 25533482 DOI: 10.1016/J.Neuron.2014.11.018  0.719
2015 Zhu H, Wang X, Wallack M, Li H, Carreras I, Dedeoglu A, Hur JY, Zheng H, Li H, Fine R, Mwamburi M, Sun X, Kowall N, Stern RA, Qiu WQ. Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer's disease. Molecular Psychiatry. 20: 252-62. PMID 24614496 DOI: 10.1038/Mp.2014.17  0.428
2014 Wang B, Wang Z, Sun L, Yang L, Li H, Cole AL, Rodriguez-Rivera J, Lu HC, Zheng H. The amyloid precursor protein controls adult hippocampal neurogenesis through GABAergic interneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 13314-25. PMID 25274811 DOI: 10.1523/Jneurosci.2848-14.2014  0.797
2014 Vassar R, Zheng H. Molecular neurodegeneration: basic biology and disease pathways. Molecular Neurodegeneration. 9: 34. PMID 25248568 DOI: 10.1186/1750-1326-9-34  0.325
2014 Li H, Guo Q, Inoue T, Polito VA, Tabuchi K, Hammer RE, Pautler RG, Taffet GE, Zheng H. Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: interplay with cerebral blood flow. Molecular Neurodegeneration. 9: 28. PMID 25108425 DOI: 10.1186/1750-1326-9-28  0.815
2014 Polito VA, Li H, Martini-Stoica H, Wang B, Yang L, Xu Y, Swartzlander DB, Palmieri M, di Ronza A, Lee VM, Sardiello M, Ballabio A, Zheng H. Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. Embo Molecular Medicine. 6: 1142-60. PMID 25069841 DOI: 10.15252/Emmm.201303671  0.829
2014 Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JL. Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3826-40. PMID 24623762 DOI: 10.1523/Jneurosci.5171-13.2014  0.799
2013 Guo Q, Li H, Cole AL, Hur JY, Li Y, Zheng H. Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau. Plos One. 8: e80706. PMID 24278307 DOI: 10.1371/Journal.Pone.0080706  0.826
2013 Zhang B, Tian M, Zheng H, Zhen Y, Yue Y, Li T, Li S, Marcantonio ER, Xie Z. Effects of anesthetic isoflurane and desflurane on human cerebrospinal fluid Aβ and τ level Anesthesiology. 119: 52-60. PMID 23438677 DOI: 10.1097/ALN.0b013e31828ce55d  0.338
2013 Li H, Guo Q, Inoue T, Pautler R, Taffet G, Zheng H. P4-326: Abnormal cerebral blood flow exacerbates amyloid pathology in an Alzheimer's disease knock-in mice model Alzheimer's & Dementia. 9: P852-P852. DOI: 10.1016/J.Jalz.2013.08.160  0.73
2012 Matrone C, Luvisetto S, La Rosa LR, Tamayev R, Pignataro A, Canu N, Yang L, Barbagallo AP, Biundo F, Lombino F, Zheng H, Ammassari-Teule M, D'Adamio L. Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance. Aging Cell. 11: 1084-93. PMID 23020178 DOI: 10.1111/Acel.12009  0.597
2012 Lian H, Shim DJ, Gaddam SS, Rodriguez-Rivera J, Bitner BR, Pautler RG, Robertson CS, Zheng H. IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery. Molecular Neurodegeneration. 7: 47. PMID 22992283 DOI: 10.1186/1750-1326-7-47  0.575
2012 Wiese M, Antebi A, Zheng H. Regulation of neuronal APL-1 expression by cholesterol starvation. Plos One. 7: e32038. PMID 22363792 DOI: 10.1371/journal.pone.0032038  0.618
2012 Guo Q, Zheng H, Justice NJ. Central CRF system perturbation in an Alzheimer's disease knockin mouse model. Neurobiology of Aging. 33: 2678-91. PMID 22336193 DOI: 10.1016/J.Neurobiolaging.2012.01.002  0.821
2012 Guo Q, Li H, Gaddam SS, Justice NJ, Robertson CS, Zheng H. Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives. The Journal of Biological Chemistry. 287: 2437-45. PMID 22144675 DOI: 10.1074/Jbc.M111.315051  0.832
2012 Guo Q, Wang Z, Li H, Wiese M, Zheng H. APP physiological and pathophysiological functions: insights from animal models. Cell Research. 22: 78-89. PMID 21769132 DOI: 10.1038/Cr.2011.116  0.83
2012 Wang Z, Yang L, Zheng H. Role of APP and Aβ in synaptic physiology. Current Alzheimer Research. 9: 217-26. PMID 21605029 DOI: 10.2174/156720512799361691  0.807
2011 Wang B, Harrison W, Overbeek PA, Zheng H. Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Development (Cambridge, England). 138: 4487-97. PMID 21937600 DOI: 10.1242/dev.067264  0.74
2011 Shim DJ, Yang L, Reed JG, Noebels JL, Chiao PJ, Zheng H. Disruption of the NF-κB/IκBα Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons. Molecular Neurodegeneration. 6: 42. PMID 21663635 DOI: 10.1186/1750-1326-6-42  0.64
2011 Zheng H, Koo EH. Biology and pathophysiology of the amyloid precursor protein. Molecular Neurodegeneration. 6: 27. PMID 21527012 DOI: 10.1186/1750-1326-6-27  0.501
2011 Barbagallo AP, Wang Z, Zheng H, D'Adamio L. The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function. Plos One. 6: e18006. PMID 21445342 DOI: 10.1371/Journal.Pone.0018006  0.804
2011 Barbagallo AP, Wang Z, Zheng H, D'Adamio L. A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function. The Journal of Biological Chemistry. 286: 8717-21. PMID 21266574 DOI: 10.1074/Jbc.C111.219873  0.786
2010 Peethumnongsin E, Yang L, Kallhoff-Muñoz V, Hu L, Takashima A, Pautler RG, Zheng H. Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13409-18. PMID 20926667 DOI: 10.1523/Jneurosci.1964-10.2010  0.835
2010 Wiese M, Antebi A, Zheng H. Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans. Plos One. 5. PMID 20862215 DOI: 10.1371/journal.pone.0012790  0.67
2010 Li H, Wang B, Wang Z, Guo Q, Tabuchi K, Hammer RE, Südhof TC, Zheng H. Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proceedings of the National Academy of Sciences of the United States of America. 107: 17362-7. PMID 20855613 DOI: 10.1073/Pnas.1012568107  0.821
2010 Smith KD, Peethumnongsin E, Lin H, Zheng H, Pautler RG. Increased Human Wildtype Tau Attenuates Axonal Transport Deficits Caused by Loss of APP in Mouse Models. Magnetic Resonance Insights. 4: 11-18. PMID 20798780  0.777
2010 Peng B, Ling J, Lee AJ, Wang Z, Chang Z, Jin W, Kang Y, Zhang R, Shim D, Wang H, Fleming JB, Zheng H, Sun SC, Chiao PJ. Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. Proceedings of the National Academy of Sciences of the United States of America. 107: 15193-8. PMID 20696914 DOI: 10.1073/Pnas.1005533107  0.769
2010 Li H, Wang Z, Wang B, Guo Q, Dolios G, Tabuchi K, Hammer RE, Südhof TC, Wang R, Zheng H. Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis. The Journal of Biological Chemistry. 285: 30598-605. PMID 20693289 DOI: 10.1074/Jbc.M110.137729  0.814
2010 Hernandez CM, Kayed R, Zheng H, Sweatt JD, Dineley KT. Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2442-53. PMID 20164328 DOI: 10.1523/Jneurosci.5038-09.2010  0.472
2010 Umeda T, Mori H, Zheng H, Tomiyama T. Regulation of cholesterol efflux by amyloid beta secretion. Journal of Neuroscience Research. 88: 1985-94. PMID 20155813 DOI: 10.1002/jnr.22360  0.332
2009 Yang L, Wang Z, Wang B, Justice NJ, Zheng H. Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15660-8. PMID 20016080 DOI: 10.1523/JNEUROSCI.4104-09.2009  0.804
2009 Shelton CC, Zhu L, Chau D, Yang L, Wang R, Djaballah H, Zheng H, Li YM. Modulation of gamma-secretase specificity using small molecule allosteric inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 106: 20228-33. PMID 19906985 DOI: 10.1073/Pnas.0910757106  0.468
2009 Wang Z, Wang B, Yang L, Guo Q, Aithmitti N, Songyang Z, Zheng H. Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10788-801. PMID 19726636 DOI: 10.1523/Jneurosci.2132-09.2009  0.813
2009 Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim SH, Zheng H, Sisodia SS, Li YM. Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. The Journal of Biological Chemistry. 284: 2967-77. PMID 19036728 DOI: 10.1074/Jbc.M807269200  0.812
2008 Kallhoff-Munoz V, Hu L, Chen X, Pautler RG, Zheng H. Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11421-31. PMID 18971484 DOI: 10.1523/Jneurosci.2873-08.2008  0.423
2008 Wiese ME, Antebi A, Zheng H. P1-091: Investigation of APP pathophysiology in C. elegans Alzheimer's & Dementia. 4: T233-T233. DOI: 10.1016/j.jalz.2008.05.677  0.485
2007 Yang L, Wang B, Long C, Wu G, Zheng H. Increased asynchronous release and aberrant calcium channel activation in amyloid precursor protein deficient neuromuscular synapses Neuroscience. 149: 768-778. PMID 17919826 DOI: 10.1016/j.neuroscience.2007.08.025  0.724
2007 Repetto E, Yoon IS, Zheng H, Kang DE. Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway. The Journal of Biological Chemistry. 282: 31504-16. PMID 17716970 DOI: 10.1074/Jbc.M704273200  0.364
2007 Wang B, Yang L, Wang Z, Zheng H. Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter. Proceedings of the National Academy of Sciences of the United States of America. 104: 14140-5. PMID 17709753 DOI: 10.1073/pnas.0704070104  0.834
2007 Smith KD, Kallhoff V, Zheng H, Pautler RG. In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease. Neuroimage. 35: 1401-8. PMID 17369054 DOI: 10.1016/J.Neuroimage.2007.01.046  0.444
2007 Kallhoff V, Peethumnongsin E, Zheng H. Lack of alpha-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease. Molecular Neurodegeneration. 2: 6. PMID 17367539 DOI: 10.1186/1750-1326-2-6  0.804
2006 Zheng H, Koo EH. The amyloid precursor protein: beyond amyloid. Molecular Neurodegeneration. 1: 5. PMID 16930452 DOI: 10.1186/1750-1326-1-5  0.468
2006 Deng Y, Tarassishin L, Kallhoff V, Peethumnongsin E, Wu L, Li YM, Zheng H. Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 3845-54. PMID 16597739 DOI: 10.1523/Jneurosci.5384-05.2006  0.842
2006 Wang R, Wang B, He W, Zheng H. Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology. The Journal of Biological Chemistry. 281: 15330-6. PMID 16574645 DOI: 10.1074/jbc.M512574200  0.811
2006 Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P. Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proceedings of the National Academy of Sciences of the United States of America. 103: 1936-40. PMID 16449385 DOI: 10.1073/Pnas.0510710103  0.472
2005 Wang R, Tang P, Wang P, Boissy RE, Zheng H. Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation. Proceedings of the National Academy of Sciences of the United States of America. 103: 353-8. PMID 16384915 DOI: 10.1073/PNAS.0509822102  0.463
2005 Han P, Dou F, Li F, Zhang X, Zhang YW, Zheng H, Lipton SA, Xu H, Liao FF. Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11542-52. PMID 16354912 DOI: 10.1523/Jneurosci.3831-05.2005  0.492
2005 Yang G, Gong YD, Gong K, Jiang WL, Kwon E, Wang P, Zheng H, Zhang XF, Gan WB, Zhao NM. Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2. Neuroscience Letters. 384: 66-71. PMID 15919150 DOI: 10.1016/J.Neulet.2005.04.040  0.504
2005 Wang P, Yang G, Mosier DR, Chang P, Zaidi T, Gong YD, Zhao NM, Dominguez B, Lee KF, Gan WB, Zheng H. Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1219-25. PMID 15689559 DOI: 10.1523/Jneurosci.4660-04.2005  0.527
2004 Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, Zheng H, Saftig P, De Strooper B, Klumperman J, Annaert W. Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. The Journal of Cell Biology. 166: 1041-54. PMID 15452145 DOI: 10.1083/Jcb.200406060  0.422
2004 Wang R, Dineley KT, Sweatt JD, Zheng H. Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis. Neuroscience. 126: 305-12. PMID 15207348 DOI: 10.1016/j.neuroscience.2004.03.048  0.441
2004 Qyang Y, Chambers SM, Wang P, Xia X, Chen X, Goodell MA, Zheng H. Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage. Biochemistry. 43: 5352-9. PMID 15122901 DOI: 10.1021/Bi049826U  0.453
2003 Wang P, Pereira FA, Beasley D, Zheng H. Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis Development. 130: 5019-5029. PMID 12930775 DOI: 10.1242/Dev.00682  0.344
2003 Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu H. Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. The Journal of Biological Chemistry. 278: 3446-54. PMID 12435726 DOI: 10.1074/Jbc.M209065200  0.407
2002 Kang DE, Soriano S, Xia X, Eberhart CG, De Strooper B, Zheng H, Koo EH. Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell. 110: 751-62. PMID 12297048 DOI: 10.1016/S0092-8674(02)00970-4  0.322
2002 Xia X, Wang P, Sun X, Soriano S, Shum WK, Yamaguchi H, Trumbauer ME, Takashima A, Koo EH, Zheng H. The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 99: 8760-5. PMID 12070348 DOI: 10.1073/Pnas.132045399  0.442
2002 Moehlmann T, Winkler E, Xia X, Edbauer D, Murrell J, Capell A, Kaether C, Zheng H, Ghetti B, Haass C, Steiner H. Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production. Proceedings of the National Academy of Sciences of the United States of America. 99: 8025-30. PMID 12048239 DOI: 10.1073/Pnas.112686799  0.491
2002 Dineley KT, Xia X, Bui D, Sweatt JD, Zheng H. Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. The Journal of Biological Chemistry. 277: 22768-80. PMID 11912199 DOI: 10.1074/jbc.M200164200  0.449
2002 Morton RA, Kuenzi FM, Fitzjohn SM, Rosahl TW, Smith D, Zheng H, Shearman M, Collingridge GL, Seabrook GR. Impairment in hippocampal long-term potentiation in mice under-expressing the Alzheimer's disease related gene presenilin-1. Neuroscience Letters. 319: 37-40. PMID 11814648 DOI: 10.1016/S0304-3940(01)02512-5  0.417
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