☰

Ari J. Firestone - Publications

Affiliations: 
Calico Life Sciences, LLC 
Area:
Oncology, Cell signaling, Chemical biology
Tree Info Similar researchers PubMed Report error

32 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Choy L, Norris S, Wu X, Kolumam G, Firestone A, Settleman J, Stokoe D. Inhibition of Aurora kinase induces endogenous retroelements to induce a type I/III interferon response via RIG-I. Cancer Research Communications. PMID 38358346 DOI: 10.1158/2767-9764.CRC-23-0432  0.306
2021 Suciu RM, Luvaga IK, Hazeen A, Weerasooriya C, Richardson SK, Firestone AJ, Shannon K, Howell AR, Cravatt BF. Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation. Bioorganic & Medicinal Chemistry Letters. 128414. PMID 34666187 DOI: 10.1016/j.bmcl.2021.128414  0.507
2021 Remsberg JR, Suciu RM, Zambetti NA, Hanigan TW, Firestone AJ, Inguva A, Long A, Ngo N, Lum KM, Henry CL, Richardson SK, Predovic M, Huang B, Dix MM, Howell AR, et al. ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth. Nature Chemical Biology. PMID 33927411 DOI: 10.1038/s41589-021-00785-8  0.546
2020 Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K. Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. Blood. PMID 32219446 DOI: 10.1182/Blood.2019003530  0.616
2020 Zambetti NA, Firestone AJ, Wong JC, Long AM, Inguva A, Remsberg JR, Suciu RM, Cravatt BF, Haigis KM, Shannon K. Abstract A25: In vivo evidence validating the palmitoylation/depalmitoylation cycle as a therapeutic target in NRAS mutant hematologic cancers Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Ras18-A25  0.563
2019 Sulahian R, Kwon JJ, Walsh KH, Pailler E, Bosse TL, Thaker M, Almanza D, Dempster JM, Pan J, Piccioni F, Dumont N, Gonzalez A, Rennhack J, Nabet B, Bachman JA, ... ... Firestone AJ, et al. Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers. Cell Reports. 29: 118-134.e8. PMID 31577942 DOI: 10.1016/J.Celrep.2019.08.090  0.519
2019 Pech M, Fong LE, Villalta JE, Chan LJ, Kharbanda S, O'Brien JJ, McAllister FE, Firestone AJ, Jan CH, Settleman J. Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. Elife. 8. PMID 31452512 DOI: 10.7554/Elife.47362  0.419
2019 Larpenteur K, Waal Ld, Wang L, Kocak M, Bryan J, Bender S, Barkho S, Kukurugya M, Goodale A, Paolella B, Cho M, McFarland J, Rothberg M, Zhu C, Trepiccio C, ... ... Firestone A, et al. Abstract C022: Large scale phenotypic screening using PRISM, integrated with functional genomic screening and transcriptional profiling accelerates target identification of cytotoxic small molecules Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-C022  0.379
2019 Boudreau A, Roth J, Rong J, Olsson N, Mader C, Byran J, Rossen J, Wang L, Larpenteur K, Goodale A, Trepicchio C, Bender S, Tsherniak A, Subramanian A, Kocak M, ... ... Firestone A, et al. Abstract B121: An oncogene-linked prodrug strategy in lung cancer Molecular Cancer Therapeutics. 18. DOI: 10.1158/1535-7163.Targ-19-B121  0.415
2017 Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang BJ, Firestone AJ, Young A, Lacap JA, Crocker L, Asthana S, Davis EM, Xu J, Akagi K, Le Beau MM, et al. KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer. Cell. PMID 28215705 DOI: 10.1016/J.Cell.2017.01.020  0.551
2017 Zambetti NA, Firestone AJ, Wong JC, Long A, Inguva A, Suciu RM, Cravatt BF, Haigis KM, Shannon KM. Genetic Validation of the Palmitoylation/Depalmitoylation Cycle As a Drug Target in NRAS Mutant Hematologic Malignancies In Vivo Blood. 130: 1221-1221. DOI: 10.1182/Blood.V130.Suppl_1.1221.1221  0.489
2016 Shankar S, Pitchiaya S, Malik R, Kothari V, Hosono Y, Yocum AK, Gundlapalli H, White Y, Firestone A, Cao X, Dhanasekaran SM, Stuckey JA, Bollag G, Shannon K, Walter NG, et al. KRAS Engages AGO2 to Enhance Cellular Transformation. Cell Reports. PMID 26854235 DOI: 10.1016/J.Celrep.2016.01.034  0.597
2016 White Y, Bagchi A, Van Ziffle J, Inguva A, Bollag G, Zhang C, Carias H, Dickens D, Loh M, Shannon K, Firestone AJ. KRAS insertion mutations are oncogenic and exhibit distinct functional properties. Nature Communications. 7: 10647. PMID 26854029 DOI: 10.1038/Ncomms10647  0.569
2016 Shankar S, Pitchiaya S, Malik R, Kothari V, Hosono Y, Yocum AK, Gundlapalli H, White Y, Firestone A, Cao X, Dhanasekaran SM, Stuckey J, Bollag G, Shannon K, Walter N, et al. Abstract LB-008: KRAS engages AGO2 to enhance cellular transformation Cancer Research. 76. DOI: 10.1158/1538-7445.Am2016-Lb-008  0.483
2015 Mroue R, Huang B, Braunstein S, Firestone AJ, Nakamura JL. Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice. Plos Genetics. 11: e1005235. PMID 26000738 DOI: 10.1371/Journal.Pgen.1005235  0.4
2015 White YN, Firestone AJ, Shannon KM. Abstract B43: Requirement for PI3 kinase interaction in K-RasG12D-driven leukemogenesis. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-B43  0.601
2015 Shankar S, Malik R, Kothari V, Hosono Y, Pitchiaya S, Kalyana-Sundaram S, Yocum A, Escara-Wilke J, Gundlapalli H, Chinnaswamy K, Shuler M, Poliakov A, Wang X, Krishnan V, White Y, ... Firestone A, et al. Abstract LB-058: Novel interactions of the RAS oncoprotein Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-058  0.598
2014 Burgess MR, Hwang E, Firestone AJ, Huang T, Xu J, Zuber J, Bohin N, Wen T, Kogan SC, Haigis KM, Sampath D, Lowe S, Shannon K, Li Q. Preclinical efficacy of MEK inhibition in Nras-mutant AML. Blood. 124: 3947-55. PMID 25361812 DOI: 10.1182/Blood-2014-05-574582  0.602
2014 Rack PG, Ni J, Payumo AY, Nguyen V, Crapster JA, Hovestadt V, Kool M, Jones DT, Mich JK, Firestone AJ, Pfister SM, Cho YJ, Chen JK. Arhgap36-dependent activation of Gli transcription factors. Proceedings of the National Academy of Sciences of the United States of America. 111: 11061-6. PMID 25024229 DOI: 10.1073/Pnas.1322362111  0.656
2014 Burgess MR, Hwang E, Firestone AJ, Huang T, Xu J, Zuber J, Bohin N, Wen T, Kogan SC, Haigis KM, Lowe SW, Shannon K, Li Q. Preclinical Efficacy of MEK Inhibition in Nras Mutant Acute Myeloid Leukemia Blood. 124: 3753-3753. DOI: 10.1182/Blood.V124.21.3753.3753  0.615
2014 White YN, Bagchi A, Van Ziffle J, Bollag G, Zhang C, Dickens DS, Loh ML, Shannon K, Firestone AJ. Biochemical and Functional Analysis of Novel KRAS Insertions in MPN and Other Cancers Blood. 124: 2207-2207. DOI: 10.1182/Blood.V124.21.2207.2207  0.576
2013 Xu J, Haigis KM, Firestone AJ, McNerney ME, Li Q, Davis E, Chen SC, Nakitandwe J, Downing J, Jacks T, Le Beau MM, Shannon K. Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation. Cancer Discovery. 3: 993-1001. PMID 23733505 DOI: 10.1158/2159-8290.Cd-13-0096  0.619
2012 Firestone AJ, Weinger JS, Maldonado M, Barlan K, Langston LD, O'Donnell M, Gelfand VI, Kapoor TM, Chen JK. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature. 484: 125-9. PMID 22425997 DOI: 10.1038/Nature10936  0.534
2010 Firestone AJ, Chen JK. Controlling destiny through chemistry: small-molecule regulators of cell fate. Acs Chemical Biology. 5: 15-34. PMID 20000447 DOI: 10.1021/Cb900249Y  0.558
2009 Hyman JM, Firestone AJ, Heine VM, Zhao Y, Ocasio CA, Han K, Sun M, Rack PG, Sinha S, Wu JJ, Solow-Cordero DE, Jiang J, Rowitch DH, Chen JK. Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade. Proceedings of the National Academy of Sciences of the United States of America. 106: 14132-7. PMID 19666565 DOI: 10.1073/Pnas.0907134106  0.715
2009 Mich JK, Blaser H, Thomas NA, Firestone AJ, Yelon D, Raz E, Chen JK. Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent. Developmental Biology. 328: 342-54. PMID 19389352 DOI: 10.1016/J.Ydbio.2009.01.036  0.718
2009 Cupido T, Rack PG, Firestone AJ, Hyman JM, Han K, Sinha S, Ocasio CA, Chen JK. The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling. Angewandte Chemie (International Ed. in English). 48: 2321-4. PMID 19222062 DOI: 10.1002/Anie.200805666  0.695
2006 Bairstow SF, Ling K, Su X, Firestone AJ, Carbonara C, Anderson RA. Type Igamma661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis. The Journal of Biological Chemistry. 281: 20632-42. PMID 16707488 DOI: 10.1074/Jbc.M601465200  0.388
2004 Doughman RL, Firestone AJ, Anderson RA. Phosphatidylinositol phosphate kinases put PI4,5P(2) in its place. The Journal of Membrane Biology. 194: 77-89. PMID 14502432 DOI: 10.1007/S00232-003-2027-7  0.351
2003 Ling K, Doughman RL, Iyer VV, Firestone AJ, Bairstow SF, Mosher DF, Schaller MD, Anderson RA. Tyrosine phosphorylation of type Igamma phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch. The Journal of Cell Biology. 163: 1339-49. PMID 14691141 DOI: 10.1083/Jcb.200310067  0.34
2003 Doughman RL, Firestone AJ, Wojtasiak ML, Bunce MW, Anderson RA. Membrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signaling. The Journal of Biological Chemistry. 278: 23036-45. PMID 12682053 DOI: 10.1074/Jbc.M211397200  0.382
2002 Ling K, Doughman RL, Firestone AJ, Bunce MW, Anderson RA. Type I gamma phosphatidylinositol phosphate kinase targets and regulates focal adhesions. Nature. 420: 89-93. PMID 12422220 DOI: 10.1038/Nature01082  0.371
Show low-probability matches.