| Year |
Citation |
Score |
| 2021 |
Munmun F, Witt-Enderby PA. Melatonin effects on bone: implications for use as a therapy for managing bone loss. Journal of Pineal Research. e12749. PMID 34085304 DOI: 10.1111/jpi.12749 |
0.318 |
|
| 2020 |
Hasan M, Browne E, Guarinoni L, Darveau T, Hilton K, Witt-Enderby PA. Anti‐cancer Effects of Melatonin, Estrogen, and Progesterone Hormone Therapy in MCF‐7 and MDA‐MB‐231 Breast Cancer Cells The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.02301 |
0.349 |
|
| 2019 |
Dodda BR, Bondi CD, Hasan M, Clafshenkel WP, Gallagher KM, Kotlarczyk MP, Sethi S, Buszko E, Latimer JJ, Cline JM, Witt-Enderby PA, Davis VL. Co-administering Melatonin With an Estradiol-Progesterone Menopausal Hormone Therapy Represses Mammary Cancer Development in a Mouse Model of HER2-Positive Breast Cancer. Frontiers in Oncology. 9: 525. PMID 31355130 DOI: 10.3389/Fonc.2019.00525 |
0.756 |
|
| 2019 |
Hasan M, Marzouk MA, Adhikari S, Wright TD, Miller BP, Matossian MD, Elliott S, Wright MK, Alzoubi MS, Collins-Burow BM, Burow ME, Holzgrabe U, Zlotos DP, Stratford RE, Witt-Enderby PA. Title: Pharmacological, mechanistic and pharmacokinetic assessment of novel melatonin-tamoxifen drug conjugates as breast cancer drugs. Molecular Pharmacology. PMID 31221824 DOI: 10.1124/Mol.119.116202 |
0.302 |
|
| 2019 |
Hasan M, Wright TD, Adhikari S, Marzouk MA, Pericoloso A, Murgas K, Burgman M, Miller BP, Holzgrabe U, Zlotos DP, Stratford RE, Witt-Enderby PA. Abstract 3893: Melatonin-tamoxifen drug conjugates: Mechanism against breast cancer cells, and pharmacokinetic assessment in female mice Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3893 |
0.307 |
|
| 2018 |
St Hilaire MA, Rahman SA, Gooley JJ, Witt-Enderby PA, Lockley SW. Relationship between melatonin and bone resorption rhythms in premenopausal women. Journal of Bone and Mineral Metabolism. PMID 29318392 DOI: 10.1007/S00774-017-0896-6 |
0.322 |
|
| 2018 |
Hasan M, Marzouk MA, Adhikari S, Wright T, Miller B, Peckich B, Yingling S, Stratford R, Zlotos D, Cavanaugh J, Witt-Enderby P. Abstract 3915: Melatonin-tamoxifen hybrid ligands and their effects on breast cancer Cancer Research. 78: 3915-3915. DOI: 10.1158/1538-7445.Am2018-3915 |
0.325 |
|
| 2017 |
Maria S, Samsonraj RM, Munmun F, Glas J, Silvestros M, Kotlarczyk MP, Rylands R, Dudakovic A, van Wijnen AJ, Enderby LT, Lassila H, Dodda B, Davis VL, Balk J, Burow M, ... ... Witt-Enderby PA, et al. Biological Effects of Melatonin on Osteoblast/Osteoclast Co-cultures, Bone and Quality of Life: implications of a role for MT2 melatonin receptors, MEK1/2 and MEK5 in melatonin-mediated osteoblastogenesis. Journal of Pineal Research. PMID 29285799 DOI: 10.1111/Jpi.12465 |
0.756 |
|
| 2017 |
Hasan M, Genovese S, Fiorito S, Epifano F, Witt-Enderby PA. Oxyprenylated Phenylpropanoids Bind to MT1 Melatonin Receptors and Inhibit Breast Cancer Cell Proliferation and Migration. Journal of Natural Products. PMID 29144746 DOI: 10.1021/Acs.Jnatprod.7B00853 |
0.355 |
|
| 2017 |
Suofu Y, Li W, Jean-Alphonse FG, Jia J, Khattar NK, Li J, Baranov SV, Leronni D, Mihalik AC, He Y, Cecon E, Wehbi VL, Kim J, Heath BE, Baranova OV, ... ... Witt-Enderby PA, et al. Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release. Proceedings of the National Academy of Sciences of the United States of America. PMID 28874589 DOI: 10.1073/Pnas.1705768114 |
0.329 |
|
| 2017 |
Wright TD, Hasan M, Witt-Enderby P, Cavanaugh J. Abstract 2365: Dual inhibition of the PI3k/Akt and MEK5/ERK5 pathways in tamoxifen resistant breast cancer Cancer Research. 77: 2365-2365. DOI: 10.1158/1538-7445.Am2017-2365 |
0.317 |
|
| 2015 |
Zlotos DP, Riad NM, Osman MB, Dodda BR, Witt-Enderby PA. Novel difluoroacetamide analogues of agomelatine and melatonin: probing the melatonin receptors for MT1selectivity Medchemcomm. 6: 1340-1344. DOI: 10.1039/C5Md00190K |
0.321 |
|
| 2014 |
Davis VL, Abukabda AB, Radio NM, Witt-Enderby PA, Clafshenkel WP, Cairone JV, Rutkowski JL. Platelet-rich preparations to improve healing. Part II: platelet activation and enrichment, leukocyte inclusion, and other selection criteria. The Journal of Oral Implantology. 40: 511-21. PMID 25106017 DOI: 10.1563/Aaid-Joi-D-12-00106 |
0.731 |
|
| 2014 |
Davis VL, Abukabda AB, Radio NM, Witt-Enderby PA, Clafshenkel WP, Cairone JV, Rutkowski JL. Platelet-rich preparations to improve healing. Part I: workable options for every size practice. The Journal of Oral Implantology. 40: 500-10. PMID 25106016 DOI: 10.1563/Aaid-Joi-D-12-00104 |
0.735 |
|
| 2014 |
Bondi CD, Alonso-Gonzalez C, Clafshenkel WP, Kotlarczyk MP, Dodda BR, Sanchez-Barcelo E, Davis VL, Witt-Enderby PA. The effect of estradiol, progesterone, and melatonin on estrous cycling and ovarian aromatase expression in intact female mice European Journal of Obstetrics Gynecology and Reproductive Biology. 174: 80-85. PMID 24373455 DOI: 10.1016/J.Ejogrb.2013.11.027 |
0.767 |
|
| 2014 |
Maria S, Witt-Enderby PA. Melatonin effects on bone: potential use for the prevention and treatment for osteopenia, osteoporosis, and periodontal disease and for use in bone-grafting procedures. Journal of Pineal Research. 56: 115-25. PMID 24372640 DOI: 10.1111/Jpi.12116 |
0.376 |
|
| 2014 |
Zlotos DP, Jockers R, Cecon E, Rivara S, Witt-Enderby PA. MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential. Journal of Medicinal Chemistry. 57: 3161-85. PMID 24228714 DOI: 10.1021/Jm401343C |
0.39 |
|
| 2014 |
Journé A, Habib SAM, Dodda BR, Morcos MNF, Sadek MS, Tadros SAA, Witt-Enderby PA, Jockers R, Zlotos DP. N1-linked melatonin dimers as bivalent ligands targeting dimeric melatonin receptors Medchemcomm. 5: 792. DOI: 10.1039/C4Md00079J |
0.333 |
|
| 2013 |
Kirker MR, Gallagher KM, Witt-Enderby PA, Davis VL. High affinity nuclear and nongenomic estradiol binding sites in the human and mouse lens. Experimental Eye Research. 112: 1-9. PMID 23597597 DOI: 10.1016/J.Exer.2013.04.002 |
0.366 |
|
| 2013 |
Witt-Enderby PA. Could the fountain of youth be all in your bones? The Journal of Oral Implantology. 39: 1-2. PMID 23402355 DOI: 10.1563/Aaid-Joi-D-12-00065 |
0.377 |
|
| 2012 |
Witt-Enderby PA, Slater JP, Johnson NA, Bondi CD, Dodda BR, Kotlarczyk MP, Clafshenkel WP, Sethi S, Higginbotham S, Rutkowski JL, Gallagher KM, Davis VL. Effects on bone by the light/dark cycle and chronic treatment with melatonin and/or hormone replacement therapy in intact female mice. Journal of Pineal Research. 53: 374-84. PMID 22639972 DOI: 10.1111/J.1600-079X.2012.01007.X |
0.705 |
|
| 2012 |
Clafshenkel WP, King TL, Kotlarczyk MP, Cline JM, Foster WG, Davis VL, Witt-Enderby PA. Morinda citrifolia (Noni) Juice Augments Mammary Gland Differentiation and Reduces Mammary Tumor Growth in Mice Expressing the Unactivated c-erbB2 Transgene. Evidence-Based Complementary and Alternative Medicine : Ecam. 2012: 487423. PMID 22619689 DOI: 10.1155/2012/487423 |
0.748 |
|
| 2012 |
Clafshenkel WP, Rutkowski JL, Palchesko RN, Romeo JD, McGowan KA, Gawalt ES, Witt-Enderby PA. A novel calcium aluminate-melatonin scaffold enhances bone regeneration within a calvarial defect. Journal of Pineal Research. 53: 206-18. PMID 22462771 DOI: 10.1111/J.1600-079X.2012.00989.X |
0.747 |
|
| 2012 |
Kotlarczyk MP, Lassila HC, O'Neil CK, D'Amico F, Enderby LT, Witt-Enderby PA, Balk JL. Melatonin osteoporosis prevention study (MOPS): a randomized, double-blind, placebo-controlled study examining the effects of melatonin on bone health and quality of life in perimenopausal women. Journal of Pineal Research. 52: 414-26. PMID 22220591 DOI: 10.1111/J.1600-079X.2011.00956.X |
0.734 |
|
| 2011 |
Markl C, Clafshenkel WP, Attia MI, Sethi S, Witt-Enderby PA, Zlotos DP. N-Acetyl-5-arylalkoxytryptamine analogs: probing the melatonin receptors for MT(1) -selectivity. Archiv Der Pharmazie. 344: 666-74. PMID 21887801 DOI: 10.1002/Ardp.201100125 |
0.756 |
|
| 2011 |
Heckman D, Attia MI, Behnam MAM, Mohsen AMY, Markl C, Julius J, Sethi S, Witt-Enderby PA, Zlotos DP. 2-[(1,3-Dihydro-2H-isoindol-2-yl)methyl]melatonin - A novel MT 2-selective melatonin receptor antagonist Medchemcomm. 2: 991-994. DOI: 10.1039/C1Md00149C |
0.614 |
|
| 2010 |
Sethi S, Radio NM, Kotlarczyk MP, Chen CT, Wei YH, Jockers R, Witt-Enderby PA. Determination of the minimal melatonin exposure required to induce osteoblast differentiation from human mesenchymal stem cells and these effects on downstream signaling pathways. Journal of Pineal Research. 49: 222-38. PMID 20626586 DOI: 10.1111/J.1600-079X.2010.00784.X |
0.748 |
|
| 2009 |
Markl C, Attia MI, Julius J, Sethi S, Witt-Enderby PA, Zlotos DP. Synthesis and pharmacological evaluation of 1,2,3,4-tetrahydropyrazino[1,2-a]indole and 2-[(phenylmethylamino)methyl]-1H-indole analogues as novel melatoninergic ligands. Bioorganic & Medicinal Chemistry. 17: 4583-94. PMID 19473848 DOI: 10.1016/J.Bmc.2009.04.068 |
0.623 |
|
| 2009 |
Grant SG, Melan MA, Latimer JJ, Witt-Enderby PA. Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives. Expert Reviews in Molecular Medicine. 11: e5. PMID 19193248 DOI: 10.1017/S1462399409000982 |
0.384 |
|
| 2009 |
Zlotos DP, Attia MI, Julius J, Sethi S, Witt-Enderby PA. 2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists. Journal of Medicinal Chemistry. 52: 826-33. PMID 19193160 DOI: 10.1021/Jm800974D |
0.618 |
|
| 2009 |
Jarzynka MJ, Passey DK, Johnson DA, Konduru NV, Fitz NF, Radio NM, Rasenick M, Benloucif S, Melan MA, Witt-Enderby PA. Microtubules modulate melatonin receptors involved in phase-shifting circadian activity rhythms: in vitro and in vivo evidence. Journal of Pineal Research. 46: 161-71. PMID 19175856 DOI: 10.1111/J.1600-079X.2008.00644.X |
0.755 |
|
| 2008 |
Attia MI, Witt-Enderby PA, Julius J. Synthesis and pharmacological evaluation of pentacyclic 6a,7-dihydrodiindole and 2,3-dihydrodiindole derivatives as novel melatoninergic ligands. Bioorganic & Medicinal Chemistry. 16: 7654-61. PMID 18657980 DOI: 10.1016/J.Bmc.2008.07.012 |
0.315 |
|
| 2008 |
Sethi S, Adams W, Pollock J, Witt-Enderby PA. C-terminal domains within human MT1 and MT2 melatonin receptors are involved in internalization processes Journal of Pineal Research. 45: 212-218. PMID 18341518 DOI: 10.1111/J.1600-079X.2008.00579.X |
0.621 |
|
| 2008 |
Bondi CD, McKeon RM, Bennett JM, Ignatius PF, Brydon L, Jockers R, Melan MA, Witt-Enderby PA. MT1 melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation. Journal of Pineal Research. 44: 288-98. PMID 18339124 DOI: 10.1111/J.1600-079X.2007.00525.X |
0.399 |
|
| 2007 |
Attia MI, Güclü D, Hertlein B, Julius J, Witt-Enderby PA, Zlotos DP. Synthesis, NMR conformational analysis and pharmacological evaluation of 7,7a,13,14-tetrahydro-6H-cyclobuta[b]pyrimido[1,2-a:3,4-a']diindole analogues as melatonin receptor ligands. Organic & Biomolecular Chemistry. 5: 2129-37. PMID 17581657 DOI: 10.1039/B705550A |
0.315 |
|
| 2006 |
Jarzynka MJ, Passey DK, Ignatius PF, Melan MA, Radio NM, Jockers R, Rasenick MM, Brydon L, Witt-Enderby PA. Modulation of melatonin receptors and G-protein function by microtubules Journal of Pineal Research. 41: 324-336. PMID 17014689 DOI: 10.1111/J.1600-079X.2006.00371.X |
0.75 |
|
| 2006 |
Witt-Enderby PA, Radio NM, Doctor JS, Davis VL. Therapeutic treatments potentially mediated by melatonin receptors: potential clinical uses in the prevention of osteoporosis, cancer and as an adjuvant therapy. Journal of Pineal Research. 41: 297-305. PMID 17014686 DOI: 10.1111/J.1600-079X.2006.00369.X |
0.767 |
|
| 2006 |
Radio NM, Doctor JS, Witt-Enderby PA. Melatonin enhances alkaline phosphatase activity in differentiating human adult mesenchymal stem cells grown in osteogenic medium via MT2 melatonin receptors and the MEK/ERK (1/2) signaling cascade. Journal of Pineal Research. 40: 332-42. PMID 16635021 DOI: 10.1111/J.1600-079X.2006.00318.X |
0.773 |
|
| 2005 |
El-Sherif Y, Witt-Enderby P, Li P, Tesoriero J, Hogan MV, Wieraszko A. Corrigendum to “The actions of a charged melatonin receptor ligand, TMEPI, and an irreversible MT2 receptor agonist, BMNEP, on mouse hippocampal evoked potentials in vitro” Life Sciences. 77: 480. DOI: 10.1016/J.Lfs.2005.01.006 |
0.338 |
|
| 2004 |
El-Sherif Y, Witt-Enderby P, Li PK, Tesoriero J, Hogan MV, Wieraszko A. The actions of a charged melatonin receptor ligand, TMEPI, and an irreversible MT2 receptor agonist, BMNEP, on mouse hippocampal evoked potentials in vitro. Life Sciences. 75: 3147-56. PMID 15488894 DOI: 10.1016/J.Lfs.2004.06.009 |
0.35 |
|
| 2004 |
Witt-Enderby PA, Jarzynka MJ, Krawitt BJ, Melan MA. Knock-down of RGS4 and beta tubulin in CHO cells expressing the human MT1 melatonin receptor prevents melatonin-induced receptor desensitization. Life Sciences. 75: 2703-15. PMID 15369705 DOI: 10.1016/J.Lfs.2004.08.002 |
0.41 |
|
| 2003 |
Masana MI, Witt-Enderby PA, Dubocovich ML. Melatonin differentially modulates the expression and function of the hMT1 and hMT2 melatonin receptors upon prolonged withdrawal. Biochemical Pharmacology. 65: 731-9. PMID 12628486 DOI: 10.1016/S0006-2952(02)01627-1 |
0.439 |
|
| 2003 |
Witt-Enderby PA, Bennett J, Jarzynka MJ, Firestine S, Melan MA. Melatonin receptors and their regulation: Biochemical and structural mechanisms Life Sciences. 72: 2183-2198. PMID 12628439 DOI: 10.1016/S0024-3205(03)00098-5 |
0.389 |
|
| 2002 |
MacKenzie RS, Melan MA, Passey DK, Witt-Enderby PA. Dual coupling of MT(1) and MT(2) melatonin receptors to cyclic AMP and phosphoinositide signal transduction cascades and their regulation following melatonin exposure. Biochemical Pharmacology. 63: 587-95. PMID 11992626 DOI: 10.1016/S0006-2952(01)00881-4 |
0.416 |
|
| 2002 |
Chu GH, Witt-Enderby PA, Jones M, Pui-Kai L. Synthesis and pharmacological analysis of high affinity melatonin receptor ligands. Chemical & Pharmaceutical Bulletin. 50: 272-5. PMID 11848222 DOI: 10.1248/Cpb.50.272 |
0.357 |
|
| 2001 |
Clemens JW, Jarzynka MJ, Witt-Enderby PA. Down-regulation of mt1 melatonin receptors in rat ovary following estrogen exposure. Life Sciences. 69: 27-35. PMID 11411803 DOI: 10.1016/S0024-3205(01)01097-9 |
0.372 |
|
| 2001 |
Bordt SL, McKeon RM, Li PK, Witt-Enderby PA, Melan MA. N1E-115 mouse neuroblastoma cells express MT1 melatonin receptors and produce neurites in response to melatonin. Biochimica Et Biophysica Acta. 1499: 257-64. PMID 11341973 DOI: 10.1016/S0167-4889(00)00127-0 |
0.385 |
|
| 2000 |
Witt-Enderby PA, MacKenzie RS, McKeon RM, Carroll EA, Bordt SL, Melan MA. Melatonin induction of filamentous structures in non-neuronal cells that is dependent on expression of the human mt1 melatonin receptor. Cell Motility and the Cytoskeleton. 46: 28-42. PMID 10842331 DOI: 10.1002/(Sici)1097-0169(200005)46:1<28::Aid-Cm4>3.0.Co;2-5 |
0.385 |
|
| 2000 |
Jones MP, Melan MA, Witt-Enderby PA. Melatonin decreases cell proliferation and transformation in a melatonin receptor-dependent manner Cancer Letters. 151: 133-143. PMID 10738107 DOI: 10.1016/S0304-3835(99)00394-8 |
0.381 |
|
| 2000 |
Witt-Enderby PA, Li PK. Melatonin receptors and ligands. Vitamins and Hormones. 58: 321-54. PMID 10668404 DOI: 10.1016/S0083-6729(00)58030-3 |
0.366 |
|
| 1998 |
Witt-Enderby PA, Masana MI, Dubocovich ML. Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor. Endocrinology. 139: 3064-71. PMID 9645677 DOI: 10.1210/Endo.139.7.6102 |
0.39 |
|
| 1997 |
Witt-Enderby PA, Chu GH, Gillen ML, Li PK. Development of a high-affinity ligand that binds irreversibly to Mel1b melatonin receptors Journal of Medicinal Chemistry. 40: 4195-4198. PMID 9435890 DOI: 10.1021/Jm970437Q |
0.322 |
|
| 1997 |
Li PK, Chu GH, Gillen ML, Parekh T, Witt-Enderby PA. The development of a charged melatonin receptor ligand Bioorganic and Medicinal Chemistry Letters. 7: 2409-2414. DOI: 10.1016/S0960-894X(97)00444-7 |
0.326 |
|
| 1997 |
Li PK, Chu GH, Gillen ML, Witt-Enderby PA. Synthesis and receptor binding studies of quinolinic derivatives as melatonin receptor ligands Bioorganic and Medicinal Chemistry Letters. 7: 2177-2180. DOI: 10.1016/S0960-894X(97)00392-2 |
0.354 |
|
| 1995 |
Pals-Rylaarsdam R, Xu Y, Witt-Enderby P, Benovic JL, Hosey MM. Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms Journal of Biological Chemistry. 270: 29004-29011. PMID 7499433 DOI: 10.1074/Jbc.270.48.29004 |
0.326 |
|
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