| Year |
Citation |
Score |
| 2019 |
Wang S, Hanna D, Sugamori KS, Grant DM. Primary aromatic amines and cancer: Novel mechanistic insights using 4-aminobiphenyl as a model carcinogen. Pharmacology & Therapeutics. PMID 31075357 DOI: 10.1016/J.Pharmthera.2019.05.004 |
0.37 |
|
| 2019 |
Denis RGP, Busi F, Castel J, Morel C, Zhang W, Bui LC, Sugamori KS, Prokopec SD, Boutros PC, Grant DM, Rodrigues-Lima F, Luquet S, Dupret JM. A readout of metabolic efficiency in arylamine N-acetyltransferase-deficient mice reveals minor energy metabolism changes. Febs Letters. PMID 30883722 DOI: 10.1002/1873-3468.13357 |
0.355 |
|
| 2018 |
Gomez A, Bindesbøll C, Somisetty VS, Grimaldi G, Hutin D, MacPherson L, Ahmed S, Tamblyn L, Cho T, Nebb HI, Moen A, Anonsen JH, Grant DM, Matthews J. Characterization of TCDD-Inducible Poly-ADP-Ribose Polymerase (TIPARP/ARTD14) Catalytic Activity. The Biochemical Journal. PMID 30373764 DOI: 10.1042/Bcj20180347 |
0.413 |
|
| 2017 |
Wang P, Shehu AI, Lu J, Joshi RH, Venkataramanan R, Sugamori KS, Grant DM, Zhong XB, Ma X. Deficiency of N-Acetyltransferase Increases the Interactions of Isoniazid with Endobiotics in mouse Liver. Biochemical Pharmacology. PMID 28888949 DOI: 10.1016/J.Bcp.2017.09.001 |
0.354 |
|
| 2017 |
Tseng CC, Noordali H, Sani M, Madhani M, Grant DM, Frenneaux MP, Zanda M, Greig IR. Development of Fluorinated Analogues of Perhexiline with Improved Pharmacokinetic Properties and Retained Efficacy. Journal of Medicinal Chemistry. PMID 28277663 DOI: 10.1021/Acs.Jmedchem.6B01592 |
0.302 |
|
| 2015 |
Wang S, Bott D, Tung A, Sugamori KS, Grant DM. Relative Contributions of CYP1A2 and CYP2E1 to the Bioactivation and Clearance of 4-Aminobiphenyl in Adult Mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 916-21. PMID 25922528 DOI: 10.1124/Dmd.115.063297 |
0.425 |
|
| 2015 |
Wang S, Sugamori KS, Tung A, McPherson JP, Grant DM. N-hydroxylation of 4-aminobiphenyl by CYP2E1 produces oxidative stress in a mouse model of chemically induced liver cancer. Toxicological Sciences : An Official Journal of the Society of Toxicology. 144: 393-405. PMID 25601990 DOI: 10.1093/Toxsci/Kfv006 |
0.363 |
|
| 2013 |
Witham KL, Butcher NJ, Sugamori KS, Brenneman D, Grant DM, Minchin RF. 5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. Plos One. 8: e77923. PMID 24205029 DOI: 10.1371/Journal.Pone.0077923 |
0.324 |
|
| 2013 |
Ogawa S, Surapisitchat J, Virtanen C, Ogawa M, Niapour M, Sugamori KS, Wang S, Tamblyn L, Guillemette C, Hoffmann E, Zhao B, Strom S, Laposa RR, Tyndale RF, Grant DM, et al. Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes. Development (Cambridge, England). 140: 3285-96. PMID 23861064 DOI: 10.1242/Dev.090266 |
0.326 |
|
| 2013 |
Wang S, Sugamori KS, Grant DM. Abstract 4795: N-hydroxylation of 4-aminobiphenyl (ABP) and associated oxidative stress may influence ABP carcinogenicity in the mouse liver. Cancer Research. 73: 4795-4795. DOI: 10.1158/1538-7445.Am2013-4795 |
0.348 |
|
| 2012 |
Wang S, Sugamori KS, Brenneman D, Hsu I, Calce A, Grant DM. Influence of arylamine N-acetyltransferase, sex, and age on 4-aminobiphenyl-induced in vivo mutant frequencies and spectra in mouse liver. Environmental and Molecular Mutagenesis. 53: 350-7. PMID 22508569 DOI: 10.1002/Em.21695 |
0.313 |
|
| 2012 |
Grant DM, Brenneman D, Sugamori KS. Abstract 4423: Transgenic liver expression of human arylamineN-acetyltransferase NAT2 restores sensitivity of male Nat1/2 null mice to 4-aminobiphenyl-induced liver tumorigenesis Cancer Research. 72: 4423-4423. DOI: 10.1158/1538-7445.Am2012-4423 |
0.32 |
|
| 2011 |
Sugamori KS, Brenneman D, Grant DM. Liver-selective expression of human arylamine N-acetyltransferase NAT2 in transgenic mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 882-90. PMID 21317369 DOI: 10.1124/Dmd.111.038216 |
0.408 |
|
| 2009 |
McConkey SE, Grant DM, Cribb AE. The role of para-aminophenol in acetaminophen-induced methemoglobinemia in dogs and cats. Journal of Veterinary Pharmacology and Therapeutics. 32: 585-95. PMID 20444014 DOI: 10.1111/J.1365-2885.2009.01080.X |
0.317 |
|
| 2008 |
Grant DM. Structures of human arylamine N-acetyltransferases. Current Drug Metabolism. 9: 465-70. PMID 18680466 DOI: 10.2174/138920008784892029 |
0.358 |
|
| 2008 |
Hein DW, Boukouvala S, Grant DM, Minchin RF, Sim E. Changes in consensus arylamine N-acetyltransferase gene nomenclature. Pharmacogenetics and Genomics. 18: 367-8. PMID 18334921 DOI: 10.1097/Fpc.0B013E3282F60Db0 |
0.36 |
|
| 2007 |
Wu H, Dombrovsky L, Tempel W, Martin F, Loppnau P, Goodfellow GH, Grant DM, Plotnikov AN. Structural basis of substrate-binding specificity of human arylamine N-acetyltransferases. The Journal of Biological Chemistry. 282: 30189-97. PMID 17656365 DOI: 10.1074/Jbc.M704138200 |
0.78 |
|
| 2007 |
Sugamori KS, Brenneman D, Wong S, Gaedigk A, Yu V, Abramovici H, Rozmahel R, Grant DM. Effect of arylamine acetyltransferase Nat3 gene knockout on N-acetylation in the mouse. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 1064-70. PMID 17403913 DOI: 10.1124/Dmd.107.015396 |
0.417 |
|
| 2006 |
Sugamori KS, Brenneman D, Grant DM. In vivo and in vitro metabolism of arylamine procarcinogens in acetyltransferase-deficient mice. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1697-702. PMID 16815960 DOI: 10.1124/Dmd.106.010819 |
0.464 |
|
| 2004 |
Grant DM. Pharmacogenetics and the regulation of gene transcription. Pharmacogenetics. 14: 391-3. PMID 15226670 DOI: 10.1097/01.Fpc.0000114752.08559.A0 |
0.413 |
|
| 2003 |
Sugamori KS, Wong S, Gaedigk A, Yu V, Abramovici H, Rozmahel R, Grant DM. Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice. Molecular Pharmacology. 64: 170-9. PMID 12815173 DOI: 10.1124/Mol.64.1.170 |
0.414 |
|
| 2001 |
Rodrigues-Lima F, Deloménie C, Goodfellow GH, Grant DM, Dupret JM. Homology modelling and structural analysis of human arylamine N-acetyltransferase NAT1: evidence for the conservation of a cysteine protease catalytic domain and an active-site loop. The Biochemical Journal. 356: 327-34. PMID 11368758 DOI: 10.1042/0264-6021:3560327 |
0.773 |
|
| 2001 |
Vaziri SA, Hughes NC, Sampson H, Darlington G, Jewett MA, Grant DM. Variation in enzymes of arylamine procarcinogen biotransformation among bladder cancer patients and control subjects. Pharmacogenetics. 11: 7-20. PMID 11207033 DOI: 10.1097/00008571-200102000-00002 |
0.396 |
|
| 2000 |
Hein DW, McQueen CA, Grant DM, Goodfellow GH, Kadlubar FF, Weber WW. Pharmacogenetics of the arylamine N-acetyltransferases: a symposium in honor of Wendell W. Weber. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 28: 1425-32. PMID 11095579 |
0.727 |
|
| 2000 |
Grant DM, Goodfellow GH, Sugamori K, Durette K. Pharmacogenetics of the human arylamine N-acetyltransferases. Pharmacology. 61: 204-11. PMID 10971207 DOI: 10.1159/000028402 |
0.784 |
|
| 2000 |
Hein DW, Grant DM, Sim E. Update on consensus arylamine N-acetyltransferase gene nomenclature. Pharmacogenetics. 10: 291-2. PMID 10862519 DOI: 10.1097/00008571-200006000-00002 |
0.347 |
|
| 2000 |
Goodfellow GH, Dupret JM, Grant DM. Identification of amino acids imparting acceptor substrate selectivity to human arylamine acetyltransferases NAT1 and NAT2. The Biochemical Journal. 348: 159-66. PMID 10794727 DOI: 10.1042/Bj3480159 |
0.775 |
|
| 2000 |
Windmill KF, Gaedigk A, Hall PM, Samaratunga H, Grant DM, McManus ME. Localization of N-acetyltransferases NAT1 and NAT2 in human tissues. Toxicological Sciences : An Official Journal of the Society of Toxicology. 54: 19-29. PMID 10746928 DOI: 10.1093/Toxsci/54.1.19 |
0.403 |
|
| 1998 |
Gaedigk A, Tyndale RF, Jurima-Romet M, Sellers EM, Grant DM, Leeder JS. NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations. Pharmacogenetics. 8: 305-13. PMID 9731717 |
0.31 |
|
| 1998 |
Lin HJ, Probst-Hensch NM, Hughes NC, Sakamoto GT, Louie AD, Kau IH, Lin BK, Lee DB, Lin J, Frankl HD, Lee ER, Hardy S, Grant DM, Haile RW. Variants of N-acetyltransferase NAT1 and a case-control study of colorectal adenomas. Pharmacogenetics. 8: 269-81. PMID 9682272 DOI: 10.1097/00008571-199806000-00009 |
0.382 |
|
| 1998 |
Bidwell LM, Gillam EMJ, Gaedigk A, Zhu X, Grant D, McManus ME. Bacterial expression of two human aryl sulfotransferases Chemico-Biological Interactions. 109: 137-141. PMID 9566741 DOI: 10.1016/S0009-2797(97)00128-2 |
0.38 |
|
| 1998 |
Gaedigk A, Lekas P, Berchuk M, Grant DM. Novel sulfotransferases cloned by RT-PCR: real proteins or PCR artifacts? Chemico-Biological Interactions. 109: 43-52. PMID 9566732 DOI: 10.1016/S0009-2797(97)00119-1 |
0.321 |
|
| 1998 |
Hughes NC, Janezic SA, McQueen KL, Jewett MA, Castranio T, Bell DA, Grant DM. Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe. Pharmacogenetics. 8: 55-66. PMID 9511182 DOI: 10.1097/00008571-199802000-00008 |
0.457 |
|
| 1997 |
Windmill KF, McKinnon RA, Zhu X, Gaedigk A, Grant DM, McManus ME. The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. Mutation Research. 376: 153-60. PMID 9202751 DOI: 10.1016/S0027-5107(97)00038-9 |
0.432 |
|
| 1997 |
Grant DM, Hughes NC, Janezic SA, Goodfellow GH, Chen HJ, Gaedigk A, Yu VL, Grewal R. Human acetyltransferase polymorphisms. Mutation Research. 376: 61-70. PMID 9202739 DOI: 10.1016/S0027-5107(97)00026-2 |
0.772 |
|
| 1997 |
Deloménie C, Goodfellow GH, Krishnamoorthy R, Grant DM, Dupret JM. Study of the role of the highly conserved residues Arg9 and Arg64 in the catalytic function of human N-acetyltransferases NAT1 and NAT2 by site-directed mutagenesis. The Biochemical Journal. 323: 207-15. PMID 9173883 DOI: 10.1042/Bj3230207 |
0.774 |
|
| 1997 |
Gaedigk A, Beatty BG, Grant DM. Cloning, structural organization, and chromosomal mapping of the human phenol sulfotransferase STP2 gene. Genomics. 40: 242-6. PMID 9119390 DOI: 10.1006/Geno.1996.4575 |
0.34 |
|
| 1996 |
Nuss CE, Grant DM, Spielberg SP, Cribb AE. Further investigations of the role of acetylation in sulphonamide hypersensitivity reactions. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. 1: 267-72. PMID 23888994 DOI: 10.3109/13547509609079367 |
0.412 |
|
| 1996 |
Deloménie C, Sica L, Grant DM, Krishnamoorthy R, Dupret JM. Genotyping of the polymorphic N-acetyltransferase (NAT2*) gene locus in two native African populations. Pharmacogenetics. 6: 177-85. PMID 9156695 DOI: 10.1097/00008571-199604000-00004 |
0.324 |
|
| 1996 |
Cribb AE, Nuss CE, Alberts DW, Lamphere DB, Grant DM, Grossman SJ, Spielberg SP. Covalent binding of sulfamethoxazole reactive metabolites to human and rat liver subcellular fractions assessed by immunochemical detection. Chemical Research in Toxicology. 9: 500-7. PMID 8839055 DOI: 10.1021/Tx950167J |
0.334 |
|
| 1995 |
Green VJ, Pirmohamed M, Kitteringham NR, Gaedigk A, Grant DM, Boxer M, Burchell B, Park BK. Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity. Biochemical Pharmacology. 50: 1353-9. PMID 7503783 DOI: 10.1016/0006-2952(95)02009-8 |
0.322 |
|
| 1994 |
Dupret JM, Goodfellow GH, Janezic SA, Grant DM. Structure-function studies of human arylamine N-acetyltransferases NAT1 and NAT2. Functional analysis of recombinant NAT1/NAT2 chimeras expressed in Escherichia coli. The Journal of Biological Chemistry. 269: 26830-5. PMID 7929420 |
0.777 |
|
| 1994 |
Gaedigk A, Spielberg SP, Grant DM. Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions. Pharmacogenetics. 4: 142-53. PMID 7920694 DOI: 10.1097/00008571-199406000-00005 |
0.401 |
|
| 1994 |
Deloménie C, Grant DM, Mathelier-Fusade P, Jacomet C, Leynadier F, Jacqz-Aigrain E, Rozenbaum W, Krishnamoorthy R, Dupret JM. N-acetylation genotype and risk of severe reactions to sulphonamides in AIDS patients. British Journal of Clinical Pharmacology. 38: 581-2. PMID 7888297 DOI: 10.1111/J.1365-2125.1994.Tb04401.X |
0.318 |
|
| 1993 |
Cribb AE, Nakamura H, Grant DM, Miller MA, Spielberg SP. Role of polymorphic and monomorphic human arylamine N-acetyltransferases in determining sulfamethoxazole metabolism. Biochemical Pharmacology. 45: 1277-82. PMID 8466547 DOI: 10.1016/0006-2952(93)90280-A |
0.455 |
|
| 1993 |
Hein DW, Doll MA, Rustan TD, Gray K, Feng Y, Ferguson RJ, Grant DM. Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases. Carcinogenesis. 14: 1633-8. PMID 8353847 DOI: 10.1093/Carcin/14.8.1633 |
0.506 |
|
| 1993 |
Grant DM. Molecular genetics of the N-acetyltransferases. Pharmacogenetics. 3: 45-50. PMID 8097948 DOI: 10.1097/00008571-199302000-00005 |
0.329 |
|
| 1992 |
Grant DM, Blum M, Meyer UA. Polymorphisms of N-acetyltransferase genes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 22: 1073-81. PMID 1441598 DOI: 10.3109/00498259209051861 |
0.516 |
|
| 1991 |
Blum M, Demierre A, Grant DM, Heim M, Meyer UA. Molecular mechanism of slow acetylation of drugs and carcinogens in humans. Proceedings of the National Academy of Sciences of the United States of America. 88: 5237-41. PMID 1675794 DOI: 10.1073/Pnas.88.12.5237 |
0.371 |
|
| 1990 |
Blum M, Grant DM, McBride W, Heim M, Meyer UA. Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression. Dna and Cell Biology. 9: 193-203. PMID 2340091 DOI: 10.1089/Dna.1990.9.193 |
0.485 |
|
| 1990 |
Grant DM, Mörike K, Eichelbaum M, Meyer UA. Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liver. The Journal of Clinical Investigation. 85: 968-72. PMID 2312737 DOI: 10.1172/Jci114527 |
0.463 |
|
| 1990 |
Meyer UA, Zanger UM, Grant D, Blum M. Genetic polymorphisms of drug metabolism. Progress in Liver Diseases. 19: 197-241. DOI: 10.1016/B978-0-12-013319-2.50007-3 |
0.352 |
|
| 1989 |
Grant DM, Lottspeich F, Meyer UA. Evidence for two closely related isozymes of arylamine N-acetyltransferase in human liver. Febs Letters. 244: 203-7. PMID 2924904 DOI: 10.1016/0014-5793(89)81193-7 |
0.506 |
|
| 1989 |
Grant DM, Blum M, Demierre A, Meyer UA. Nucleotide sequence of an intronless gene for a human arylamine N-acetyltransferase related to polymorphic drug acetylation. Nucleic Acids Research. 17: 3978. PMID 2734109 DOI: 10.1093/Nar/17.10.3978 |
0.423 |
|
| 1989 |
Blum M, Grant DM, Demierre A, Meyer UA. Nucleotide sequence of a full-length cDNA for arylamine N-acetyltransferase from rabbit liver. Nucleic Acids Research. 17: 3589. PMID 2726493 DOI: 10.1093/Nar/17.9.3589 |
0.335 |
|
| 1989 |
Meyer UA, Zanger U, Skoda R, Grant DM. Genetic polymorphisms of drug-metabolizing enzymes: molecular mechanisms. Psychopharmacology Series. 7: 141-7. PMID 2687852 DOI: 10.1007/978-3-642-74430-3_15 |
0.375 |
|
| 1989 |
Blum M, Grant DM, Demierre A, Meyer UA. N-acetylation pharmacogenetics: a gene deletion causes absence of arylamine N-acetyltransferase in liver of slow acetylator rabbits. Proceedings of the National Academy of Sciences of the United States of America. 86: 9554-7. PMID 2594784 DOI: 10.1073/Pnas.86.23.9554 |
0.456 |
|
| 1987 |
Grant DM, Campbell ME, Tang BK, Kalow W. Biotransformation of caffeine by microsomes from human liver. Kinetics and inhibition studies. Biochemical Pharmacology. 36: 1251-60. PMID 3593412 DOI: 10.1016/0006-2952(87)90078-5 |
0.4 |
|
| 1986 |
Shear NH, Spielberg SP, Grant DM, Tang BK, Kalow W. Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity. Annals of Internal Medicine. 105: 179-84. PMID 3729200 DOI: 10.7326/0003-4819-105-2-179 |
0.305 |
|
| 1983 |
Grant DM, Tang BK, Kalow W. Polymorphic N-acetylation of a caffeine metabolite. Clinical Pharmacology and Therapeutics. 33: 355-9. PMID 6825389 DOI: 10.1038/Clpt.1983.45 |
0.44 |
|
| 1983 |
Grant DM, Tang BK, Kalow W. Variability in caffeine metabolism. Clinical Pharmacology and Therapeutics. 33: 591-602. PMID 6687705 DOI: 10.1038/Clpt.1983.80 |
0.393 |
|
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