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John E. Mittler, Ph.D. - Publications

Affiliations: 
University of Washington, Seattle, Seattle, WA 
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Manocheewa S, Mittler JE, Samudrala R, Mullins JI. Composite Sequence-Structure Stability Models as Screening Tools for Identifying Vulnerable Targets for HIV Drug and Vaccine Development. Viruses. 7: 5718-35. PMID 26556362 DOI: 10.3390/V7112901  0.374
2014 Herbeck JT, Mittler JE, Gottlieb GS, Mullins JI. An HIV epidemic model based on viral load dynamics: value in assessing empirical trends in HIV virulence and community viral load. Plos Computational Biology. 10: e1003673. PMID 24945322 DOI: 10.1371/Journal.Pcbi.1003673  0.376
2012 McClure J, Lovelace ES, Elahi S, Maurice NJ, Wagoner J, Dragavon J, Mittler JE, Kraft Z, Stamatatos L, Stamatatos L, Horton H, De Rosa SC, Coombs RW, Polyak SJ. Silibinin inhibits HIV-1 infection by reducing cellular activation and proliferation. Plos One. 7: e41832. PMID 22848626 DOI: 10.1371/Journal.Pone.0041832  0.341
2012 McClure J, Lovelace ES, Elahi S, Maurice NJ, Wagoner J, Dragavon J, Mittler JE, Kraft Z, Stamatatos L, Horton H, De Rosa SC, Coombs RW, Polyak SJ. Correction: Silibinin Inhibits HIV-1 Infection by Reducing Cellular Activation and Proliferation Plos One. 7. DOI: 10.1371/Annotation/78Ba072A-6B7A-430A-8Fcd-Ef020E4Fc458  0.318
2011 Lim HC, Curlin ME, Mittler JE. HIV Therapy Simulator: a graphical user interface for comparing the effectiveness of novel therapy regimens. Bioinformatics (Oxford, England). 27: 3065-6. PMID 21908542 DOI: 10.1093/Bioinformatics/Btr515  0.31
2009 Heath L, Fox A, McClure J, Diem K, van 't Wout AB, Zhao H, Park DR, Schouten JT, Twigg HL, Corey L, Mullins JI, Mittler JE. Evidence for limited genetic compartmentalization of HIV-1 between lung and blood. Plos One. 4: e6949. PMID 19759830 DOI: 10.1371/Journal.Pone.0006949  0.305
2008 Liu Y, Mittler JE. Selection dramatically reduces effective population size in HIV-1 infection. Bmc Evolutionary Biology. 8: 133. PMID 18454872 DOI: 10.1186/1471-2148-8-133  0.398
2008 Curlin ME, Wilkin T, Mittler J. Induction-maintenance therapy for HIV-1 infection Future Hiv Therapy. 2: 175-185. DOI: 10.2217/17469600.2.2.175  0.36
2007 Curlin ME, Iyer S, Mittler JE. Optimal timing and duration of induction therapy for HIV-1 infection. Plos Computational Biology. 3: e133. PMID 17630827 DOI: 10.1371/Journal.Pcbi.0030133  0.322
2007 McClure J, van't Wout AB, Tran T, Mittler JE. Granulocyte-monocyte colony-stimulating factor upregulates HIV-1 replication in monocyte-derived macrophages cultured at low density. Journal of Acquired Immune Deficiency Syndromes (1999). 44: 254-61. PMID 17211283 DOI: 10.1097/Qai.0B013E318030F5C5  0.316
2006 Wang K, Mittler JE, Samudrala R. Comment on "Evidence for positive epistasis in HIV-1". Science (New York, N.Y.). 312: 848; author reply 84. PMID 16690844 DOI: 10.1126/Science.1109904  0.334
2006 Liu Y, Mullins JI, Mittler JE. Waiting times for the appearance of cytotoxic T-lymphocyte escape mutants in chronic HIV-1 infection. Virology. 347: 140-6. PMID 16387340 DOI: 10.1016/J.Virol.2005.11.036  0.429
2005 Jenwitheesuk E, Wang K, Mittler JE, Samudrala R. PIRSpred: a web server for reliable HIV-1 protein-inhibitor resistance/susceptibility prediction. Trends in Microbiology. 13: 150-1. PMID 15817383 DOI: 10.1016/J.Tim.2005.02.003  0.366
2004 Wang K, Samudrala R, Mittler JE. HIV-1 genotypic drug-resistance interpretation algorithms need to include hypersusceptibility-associated mutations. The Journal of Infectious Diseases. 190: 2055-6; author reply. PMID 15529272 DOI: 10.1086/423489  0.378
2004 Liu Y, Nickle DC, Shriner D, Jensen MA, Learn GH, Mittler JE, Mullins JI. Molecular clock-like evolution of human immunodeficiency virus type 1. Virology. 329: 101-8. PMID 15476878 DOI: 10.1016/J.Virol.2004.08.014  0.308
2004 Jenwitheesuk E, Wang K, Mittler JE, Samudrala R. Improved accuracy of HIV-1 genotypic susceptibility interpretation using a consensus approach. Aids (London, England). 18: 1858-9. PMID 15316352 DOI: 10.1097/00002030-200409030-00020  0.327
2004 Shriner D, Shankarappa R, Jensen MA, Nickle DC, Mittler JE, Margolick JB, Mullins JI. Influence of random genetic drift on human immunodeficiency virus type 1 env evolution during chronic infection. Genetics. 166: 1155-64. PMID 15082537 DOI: 10.1534/Genetics.166.3.1155  0.388
2003 Nickle DC, Shriner D, Mittler JE, Frenkel LM, Mullins JI. Importance and detection of virus reservoirs and compartments of HIV infection. Current Opinion in Microbiology. 6: 410-6. PMID 12941414 DOI: 10.1016/S1369-5274(03)00096-1  0.341
2002 Liu SL, Mittler JE, Nickle DC, Mulvania TM, Shriner D, Rodrigo AG, Kosloff B, He X, Corey L, Mullins JI. Selection for human immunodeficiency virus type 1 recombinants in a patient with rapid progression to AIDS. Journal of Virology. 76: 10674-84. PMID 12368309 DOI: 10.1128/Jvi.76.21.10674-10684.2002  0.385
2001 Nelson PW, Mittler JE, Perelson AS. Effect of drug efficacy and the eclipse phase of the viral life cycle on estimates of HIV viral dynamic parameters. Journal of Acquired Immune Deficiency Syndromes (1999). 26: 405-12. PMID 11391159 DOI: 10.1097/00126334-200104150-00002  0.34
2001 Mittler J, Essunger P, Yuen GJ, Clendeninn N, Markowitz M, Perelson AS. Short-term measures of relative efficacy predict longer-term reductions in human immunodeficiency virus type 1 RNA levels following nelfinavir monotherapy Antimicrobial Agents and Chemotherapy. 45: 1438-1443. PMID 11302807 DOI: 10.1128/Aac.45.5.1438-1443.2001  0.305
2001 Karlsson AC, Birk M, Lindbäck S, Gaines H, Mittler JE, Sönnerborg A. Initiation of therapy during primary HIV type 1 infection results in a continuous decay of proviral DNA and a highly restricted viral evolution. Aids Research and Human Retroviruses. 17: 409-16. PMID 11282009 DOI: 10.1089/088922201750102463  0.359
2000 Lindback S, Karlsson AC, Mittler J, Blaxhult A, Carlsson M, Briheim G, Sonnerborg A, Gaines H. Viral dynamics in primary HIV-1 infection Aids. 14: 2283-2291. PMID 11089616 DOI: 10.1097/00002030-200010200-00009  0.36
2000 Ramratnam B, Mittler JE, Zhang L, Boden D, Hurley A, Fang F, Macken CA, Perelson AS, Markowitz M, Ho DD. The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy. Nature Medicine. 6: 82-5. PMID 10613829 DOI: 10.1038/71577  0.375
1999 Ramratnam B, Bonhoeffer S, Binley J, Hurley A, Zhang L, Mittler JE, Markowitz M, Moore JP, Perelson AS, Ho DD. Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet (London, England). 354: 1782-5. PMID 10577640 DOI: 10.1016/S0140-6736(99)02035-8  0.339
1999 Mittler JE, Markowitz M, Ho DD, Perelson AS. Improved estimates for HIV-1 clearance rate and intracellular delay. Aids (London, England). 13: 1415-7. PMID 10449298 DOI: 10.1097/00002030-199907300-00023  0.33
1998 Mittler JE, Sulzer B, Neumann AU, Perelson AS. Influence of delayed viral production on viral dynamics in HIV-1 infected patients. Mathematical Biosciences. 152: 143-63. PMID 9780612 DOI: 10.1016/S0025-5564(98)10027-5  0.346
1998 Notermans DW, Goudsmit J, Danner SA, de Wolf F, Perelson AS, Mittler J. Rate of HIV-1 decline following antiretroviral therapy is related to viral load at baseline and drug regimen. Aids (London, England). 12: 1483-90. PMID 9727569 DOI: 10.1097/00002030-199812000-00010  0.358
1998 Stewart FM, Antia R, Levin BR, Lipsitch M, Mittler JE. The population genetics of antibiotic resistance. II: Analytic theory for sustained populations of bacteria in a community of hosts. Theoretical Population Biology. 53: 152-65. PMID 9615474 DOI: 10.1006/Tpbi.1997.1352  0.481
1998 Eastman PS, Mittler J, Kelso R, Gee C, Boyer E, Kolberg J, Urdea M, Leonard JM, Norbeck DW, Mo H, Markowitz M. Genotypic changes in human immunodeficiency virus type 1 associated with loss of suppression of plasma viral RNA levels in subjects treated with ritonavir (Norvir) monotherapy. Journal of Virology. 72: 5154-64. PMID 9573287 DOI: 10.1128/Jvi.72.6.5154-5164.1998  0.388
1996 Mittler JE, Levin BR, Antia R. T-cell homeostasis, competition, and drift: AIDS as HIV-accelerated senescence of the immune repertoire. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association. 12: 233-48. PMID 8673527 DOI: 10.1097/00042560-199607000-00003  0.527
1995 Mittler J, Antia R, Levin B. Population dynamics of HIV pathogenesis Trends in Ecology & Evolution. 10: 224-227. DOI: 10.1016/S0169-5347(00)89069-2  0.532
1993 Lenski RE, Mittler JE. Response. Science (New York, N.Y.). 262: 318-9. PMID 17789902 DOI: 10.1126/science.262.5132.318  0.427
1993 Lenski RE, Mittler JE. Response. Science (New York, N.Y.). 260: 1222-4. PMID 17755405 DOI: 10.1126/science.260.5112.1222  0.427
1993 Lenski RE, Mittler JE. The directed mutation controversy and neo-Darwinism. Science (New York, N.Y.). 259: 188-94. PMID 7678468 DOI: 10.1126/Science.7678468  0.558
1993 Lenski RE, Mittler JE. Response [3] Science. 260: 1222-1224.  0.427
1993 Lenski RE, Mittler JE. Whither directed mutation? [3] Science. 262: 318-319.  0.491
1992 Bennett AF, Lenski RE, Mittler JE. EVOLUTIONARY ADAPTATION TO TEMPERATURE. I. FITNESS RESPONSES OF ESCHERICHIA COLI TO CHANGES IN ITS THERMAL ENVIRONMENT. Evolution; International Journal of Organic Evolution. 46: 16-30. PMID 28564952 DOI: 10.1111/J.1558-5646.1992.Tb01981.X  0.485
1992 Mittler JE, Lenski RE. Experimental evidence for an alternative to directed mutation in the bgl operon. Nature. 356: 446-8. PMID 1557128 DOI: 10.1038/356446A0  0.553
1992 Bennett AF, Lenski RE, Mittler JE. Evolutionary adaptation to temperature. I. Fitness responses of Escherichia coli to changes in its thermal environment Evolution. 46: 16-30.  0.437
1990 Mittler JE, Lenski RE. New data on excisions of Mu from E. coli MCS2 cast doubt on directed mutation hypothesis. Nature. 344: 173-5. PMID 2407962 DOI: 10.1038/344173A0  0.557
1990 Mittler JE, Lenski R. Causes of mutation and Mu excision Nature. 345: 213-213. DOI: 10.1038/345213B0  0.533
1990 Mittler JE, Lenski RE. Causes of mutation and Mu excision [11] Nature. 345: 213.  0.491
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