☰

cached image

Timothy R. Newhouse, Ph.D. - Publications

Affiliations: 
Chemistry Yale University, New Haven, CT 
Area:
Organic Chemistry, Organic Synthesis, Total Synthesis
Website:
http://www.chem.yale.edu/faculty/newhouse.html
Tree Info Similar researchers PubMed Report error

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Bodnar AK, Szewczyk SM, Sun Y, Chen Y, Huang AX, Newhouse TR. Comprehensive Mechanistic Analysis of Palladium- and Nickel-Catalyzed α,β-Dehydrogenation of Carbonyls via Organozinc Intermediates. The Journal of Organic Chemistry. PMID 38377547 DOI: 10.1021/acs.joc.3c02572  0.805
2023 Cuomo AE, Ibarraran S, Sreekumar S, Li H, Eun J, Menzel JP, Zhang P, Buono F, Song JJ, Crabtree RH, Batista VS, Newhouse TR. Feed-Forward Neural Network for Predicting Enantioselectivity of the Asymmetric Negishi Reaction. Acs Central Science. 9: 1768-1774. PMID 37780365 DOI: 10.1021/acscentsci.3c00512  0.499
2023 Zhang P, Newhouse TR. Palladium-Catalyzed Carbonylative Difunctionalization of Unactivated Alkenes Initiated by Unstabilized Enolates. Angewandte Chemie (International Ed. in English). e202307455. PMID 37319375 DOI: 10.1002/anie.202307455  0.593
2023 Kim DE, Zhu Y, Harada S, Aguilar I, Cuomo AE, Wang M, Newhouse TR. Total Synthesis of (+)-Shearilicine. Journal of the American Chemical Society. PMID 36790949 DOI: 10.1021/jacs.2c13584  0.783
2022 Schuppe AW, Liu Y, Gonzalez-Hurtado E, Zhao Y, Jiang X, Ibarraran S, Huang D, Wang E, Lee J, Loria JP, Dixit VD, Li X, Newhouse TR. Unified Total Synthesis of the Limonoid Alkaloids: Strategies for the De Novo Synthesis of Highly Substituted Pyridine Scaffolds. Chem. 8: 2856-2887. PMID 37396824 DOI: 10.1016/j.chempr.2022.09.012  0.801
2022 Zhang P, Wang J, Robertson ZR, Newhouse TR. Coordination-Controlled Nickel-Catalyzed Benzylic Allylation of Unactivated Electron-Deficient Heterocycles. Angewandte Chemie (International Ed. in English). PMID 35243738 DOI: 10.1002/anie.202200602  0.583
2021 Huang D, Newhouse TR. Dehydrogenative Pd and Ni Catalysis for Total Synthesis. Accounts of Chemical Research. PMID 33592147 DOI: 10.1021/acs.accounts.0c00787  0.577
2021 Shi CY, Eun J, Newhouse TR, Yin L. Copper(I)-Catalyzed Asymmetric Conjugate 1,6-, 1,8-, and 1,10-Borylation. Angewandte Chemie (International Ed. in English). PMID 33543574 DOI: 10.1002/anie.202016081  0.368
2020 Schuppe AW, Liu Y, Newhouse TR. An invocation for computational evaluation of isomerization transforms: cationic skeletal reorganizations as a case study. Natural Product Reports. PMID 32931541 DOI: 10.1039/D0Np00005A  0.796
2020 Liu Y, Holt TA, Kutateladze A, Newhouse TR. Stereochemical revision of xylogranatin F by GIAO and DU8+ NMR calculations. Chirality. PMID 32125044 DOI: 10.1002/Chir.23189  0.308
2020 Olivieri D, Huang D, Bodnar AK, Yu S, Newhouse TR. Zinc-mediated anionic cyclization of unstabilized ketone enolates with unactivated alkenes Tetrahedron. 131417. DOI: 10.1016/J.Tet.2020.131417  0.543
2019 Zhang P, Huang D, Newhouse TR. Aryl-Nickel-Catalyzed Benzylic Dehydrogenation of Electron-Deficient Heteroarenes. Journal of the American Chemical Society. PMID 31847514 DOI: 10.1021/Jacs.9B12706  0.642
2019 Huang D, Olivieri D, Sun Y, Zhang P, Newhouse TR. Nickel-Catalyzed Difunctionalization of Unactivated Alkenes Initiated by Unstabilized Enolates. Journal of the American Chemical Society. PMID 31556612 DOI: 10.1021/Jacs.9B09245  0.674
2019 Schuppe AW, Zhao Y, Liu Y, Newhouse TR. Total Synthesis of (+)-Granatumine A and Related Bislactone Limonoid Alkaloids via a Pyran to Pyridine Interconversion. Journal of the American Chemical Society. PMID 31117671 DOI: 10.1021/Jacs.9B04508  0.812
2019 Turlik A, Chen Y, Scruse AC, Newhouse TR. Convergent Total Synthesis of Principinol D, a Rearranged Kaurane Diterpenoid. Journal of the American Chemical Society. PMID 31042866 DOI: 10.1021/Jacs.9B03751  0.797
2019 Huang D, Szewczyk SM, Zhang P, Newhouse TR. Allyl-Nickel Catalysis Enables Carbonyl Dehydrogenation and Oxidative Cycloalkenylation of Ketones. Journal of the American Chemical Society. PMID 30861346 DOI: 10.1021/Jacs.9B02552  0.807
2019 Kim DE, Zweig JE, Newhouse TR. Total Synthesis of Paspaline A and Emindole PB Enabled by Computational Augmentation of a Transform-Guided Retrosynthetic Strategy. Journal of the American Chemical Society. PMID 30626183 DOI: 10.1021/Jacs.8B13127  0.783
2019 Elkin M, Scruse AC, Turlik A, Newhouse TR. Computational and Synthetic Investigation of Cationic Rearrangement in the Putative Biosynthesis of Justicane Triterpenoids. Angewandte Chemie (International Ed. in English). 58: 1025-1029. PMID 30575223 DOI: 10.1002/Anie.201810566  0.791
2019 Zweig JE, Ko TA, Huang J, Newhouse TR. Effects of π-extension on pyrrole hemithioindigo photoswitches Tetrahedron. 75: 130466. DOI: 10.1016/J.Tet.2019.130466  0.773
2019 Zhang P, Newhouse TR. Oxidation Stepping Stones: α-Oxytriflation Enables Asymmetric Arylation of Amides Chem. 5: 1690-1692. DOI: 10.1016/J.Chempr.2019.06.008  0.452
2018 Coleman RA, Muli CS, Zhao Y, Bhardwaj A, Newhouse TR, Trader DJ. Analysis of chain length, substitution patterns, and unsaturation of AM-404 derivatives as 20S proteasome stimulators. Bioorganic & Medicinal Chemistry Letters. PMID 30587447 DOI: 10.1016/J.Bmcl.2018.12.030  0.653
2018 Kim DE, Zhu Y, Newhouse TR. Vinylogous acyl triflates as an entry point to α,β-disubstituted cyclic enones via Suzuki-Miyaura cross-coupling. Organic & Biomolecular Chemistry. PMID 30500029 DOI: 10.1039/C8Ob02573H  0.785
2018 Elkin M, Newhouse TR. Computational chemistry strategies in natural product synthesis. Chemical Society Reviews. PMID 30083692 DOI: 10.1039/C8Cs00351C  0.681
2018 Zhang HJ, Schuppe AW, Pan ST, Chen JX, Wang BR, Newhouse TR, Yin L. Copper-Catalyzed Vinylogous Aerobic Oxidation of Unsaturated Compounds with Air. Journal of the American Chemical Society. PMID 29547276 DOI: 10.1021/Jacs.8B01886  0.788
2018 Schuppe AW, Huang D, Chen Y, Newhouse TR. Total Synthesis of (-)-Xylogranatopyridine B via a Palladium-Catalyzed Oxidative Stannylation of Enones. Journal of the American Chemical Society. PMID 29338207 DOI: 10.1021/Jacs.7B13189  0.831
2018 Huang D, Zhao Y, Newhouse TR. Synthesis of Cyclic Enones by Allyl-Palladium-Catalyzed α,β-Dehydrogenation. Organic Letters. PMID 29327930 DOI: 10.1021/Acs.Orglett.7B03818  0.768
2018 Szewczyk SM, Zhao Y, Sakai HA, Dube P, Newhouse TR. α,β-Dehydrogenation of esters with free O H and N H functionalities via allyl-palladium catalysis Tetrahedron. 74: 3293-3300. DOI: 10.1016/J.Tet.2018.02.028  0.778
2017 Schuppe AW, Cabrera JM, McGeoch CLB, Newhouse TR. Scalable synthesis of enaminones utilizing Gold's reagents. Tetrahedron, Asymmetry. 73: 3643-3651. PMID 31827315 DOI: 10.1016/J.Tet.2017.03.092  0.801
2017 Xu G, Elkin M, Tantillo D, Newhouse T, Maimone T. Traversing Biosynthetic Carbocation Landscapes in the Total Synthesis of Andrastin and Terretonin Meroterpenes. Angewandte Chemie (International Ed. in English). PMID 28799296 DOI: 10.1002/Anie.201705654  0.768
2017 Zhao Y, Chen Y, Newhouse TR. Allyl-Palladium Catalyzed Alpha,Beta-Dehydrogenation of Carboxylic Acids via Enediolates. Angewandte Chemie (International Ed. in English). PMID 28796936 DOI: 10.1002/Ange.201706893  0.752
2017 Zweig JE, Newhouse TR. Isomer-Specific Hydrogen Bonding as a Design Principle for Bidirectionally Quantitative and Redshifted Hemithioindigo Photoswitches. Journal of the American Chemical Society. PMID 28749144 DOI: 10.1021/Jacs.7B04448  0.746
2017 Chen Y, Huang D, Zhao Y, Newhouse TR. Allyl-Palladium Catalyzed Ketone Dehydrogenation Enables Telescoping with Enone Alpha,Beta-Vicinal Difunctionalization. Angewandte Chemie (International Ed. in English). PMID 28561999 DOI: 10.1002/Anie.201704874  0.785
2017 Zweig JE, Kim DE, Newhouse TR. Methods Utilizing First-Row Transition Metals in Natural Product Total Synthesis. Chemical Reviews. PMID 28525261 DOI: 10.1021/Acs.Chemrev.6B00833  0.762
2017 Elkin M, Szewczyk SM, Scruse AC, Newhouse TR. Total Synthesis of (±)-Berkeleyone A. Journal of the American Chemical Society. PMID 28102673 DOI: 10.1021/Jacs.6B12914  0.786
2017 Zhao Y, Chen Y, Newhouse TR. Palladium-Catalyzed α,β-Dehydrogenation of Carboxylic Acids Synfacts. 13: 1337. DOI: 10.1055/S-0036-1592039  0.391
2017 Newhouse T, Schuppe A. Total Synthesis of (±)-Andirolide N Synfacts. 13: 672-672. DOI: 10.1055/S-0036-1590505  0.755
2016 Schuppe AW, Newhouse TR. Assembly of the Limonoid Architecture by a Divergent Approach: Total Synthesis of (±)-Andirolide N via (±)-8-Hydroxycarapin. Journal of the American Chemical Society. PMID 28001380 DOI: 10.1021/Jacs.6B12268  0.784
2016 Huang D, Schuppe AW, Liang MZ, Newhouse TR. Scalable procedure for the fragmentation of hydroperoxides mediated by copper and iron tetrafluoroborate salts. Organic & Biomolecular Chemistry. PMID 27273761 DOI: 10.1039/C6Ob00941G  0.761
2016 Chen Y, Turlik A, Newhouse TR. Amide α,β-Dehydrogenation Using Allyl-Palladium Catalysis and a Hindered Monodentate Anilide. Journal of the American Chemical Society. PMID 26790471 DOI: 10.1021/Jacs.5B12924  0.818
2016 Turlik A, Chen Y, Newhouse TR. Dehydrogenation Adjacent to Carbonyls Using Palladium-Allyl Intermediates Synlett. 27: 331-336. DOI: 10.1055/S-0035-1560427  0.81
2015 Chen Y, Romaire JP, Newhouse TR. Palladium-Catalyzed α,β-Dehydrogenation of Esters and Nitriles. Journal of the American Chemical Society. 137: 5875-8. PMID 25918857 DOI: 10.1021/Jacs.5B02243  0.605
2015 Goldstein RI, Guo R, Hughes C, Maurer DP, Newhouse TR, Sisto TJ, Conry RR, Price SL, Thamattoor DM. Concomitant conformational dimorphism in 1,2-bis(9-anthryl)acetylene Crystengcomm. 17: 4877-4882. DOI: 10.1039/C5Ce00745C  0.319
2013 Newhouse TR, Kaib PS, Gross AW, Corey EJ. Versatile approaches for the synthesis of fused-ring γ-lactones utilizing cyclopropane intermediates. Organic Letters. 15: 1591-3. PMID 23470216 DOI: 10.1021/Ol400362T  0.647
2013 Zou L, Paton RS, Eschenmoser A, Newhouse TR, Baran PS, Houk KN. Enhanced reactivity in dioxirane C-H oxidations via strain release: a computational and experimental study. The Journal of Organic Chemistry. 78: 4037-48. PMID 23461537 DOI: 10.1021/Jo400350V  0.624
2012 Newhouse TR, Li X, Blewett MM, Whitehead CM, Corey EJ. A tetradentate ligand for the enantioselective Ti(IV)-promoted oxidation of sulfides to sulfoxides: origin of enantioselectivity. Journal of the American Chemical Society. 134: 17354-7. PMID 23046346 DOI: 10.1021/Ja305991K  0.554
2011 Newhouse T, Baran PS. If C-H bonds could talk: selective C-H bond oxidation. Angewandte Chemie (International Ed. in English). 50: 3362-74. PMID 21413105 DOI: 10.1002/Anie.201006368  0.62
2011 Foo K, Newhouse T, Mori I, Takayama H, Baran PS. Total synthesis guided structure elucidation of (+)-psychotetramine. Angewandte Chemie (International Ed. in English). 50: 2716-9. PMID 21387473 DOI: 10.1002/Anie.201008048  0.682
2011 Foo K, Newhouse T, Mori I, Takayama H, Baran PS. Synthesis of (+)-Psychotetramine Synfacts. 2011: 706-706. DOI: 10.1055/S-0030-1260493  0.695
2011 Newhouse T, Baran PS. Wenn C-H-Bindungen sprechen könnten - selektive Oxidationen von C-H-Bindungen Angewandte Chemie. 123: 3422-3435. DOI: 10.1002/Ange.201006368  0.57
2010 Schallenberger MA, Newhouse T, Baran PS, Romesberg FE. The psychotrimine natural products have antibacterial activity against Gram-positive bacteria and act via membrane disruption. The Journal of Antibiotics. 63: 685-7. PMID 20924383 DOI: 10.1038/Ja.2010.107  0.583
2010 Newhouse T, Lewis CA, Eastman KJ, Baran PS. Scalable total syntheses of N-linked tryptamine dimers by direct indole-aniline coupling: psychotrimine and kapakahines B and F. Journal of the American Chemical Society. 132: 7119-37. PMID 20426477 DOI: 10.1021/Ja1009458  0.737
2009 Newhouse T, Baran PS, Hoffmann RW. The economies of synthesis. Chemical Society Reviews. 38: 3010-21. PMID 19847337 DOI: 10.1039/B821200G  0.674
2009 Newhouse T, Lewis CA, Baran PS. Enantiospecific total syntheses of kapakahines B and F. Journal of the American Chemical Society. 131: 6360-1. PMID 19374357 DOI: 10.1021/Ja901573X  0.748
2009 Newhouse T, Lewis CA, Baran PS. Synthesis of Kapakahines B and F Synfacts. 2009: 1183-1183. DOI: 10.1055/S-0029-1218029  0.7
2009 Baran P, Newhouse T. Synthesis of ()-Psychotrimine Synfacts. 2009: 0235-0235. DOI: 10.1055/S-0028-1087698  0.695
2008 Newhouse T, Baran PS. Total synthesis of (+/-)-psychotrimine. Journal of the American Chemical Society. 130: 10886-7. PMID 18656919 DOI: 10.1021/Ja8042307  0.701
Show low-probability matches.