Year |
Citation |
Score |
2023 |
Sarosh A, Kwong SM, Jensen SO, Northern F, Walton WG, Eakes TC, Redinbo MR, Firth N, McLaughlin KJ. pSK41/pGO1-family conjugative plasmids of Staphylococcus aureus encode a cryptic repressor of replication. Plasmid. 128: 102708. PMID 37967733 DOI: 10.1016/j.plasmid.2023.102708 |
0.791 |
|
2020 |
Ervin SM, Simpson JB, Gibbs ME, Creekmore BC, Lim L, Walton WG, Gharaibeh RZ, Redinbo MR. Structural Insights into Endobiotic Reactivation by Human Gut Microbiome-Encoded Sulfatases. Biochemistry. PMID 32993284 DOI: 10.1021/acs.biochem.0c00711 |
0.318 |
|
2020 |
Ervin SM, Redinbo MR. The Gut Microbiota Impacts Cancer Etiology through "Phase IV Metabolism" of Drugs and Endobiotics. Cancer Prevention Research (Philadelphia, Pa.). PMID 32611614 DOI: 10.1158/1940-6207.Capr-20-0155 |
0.314 |
|
2020 |
Bhatt AP, Pellock SJ, Biernat KA, Walton WG, Wallace BD, Creekmore BC, Letertre MM, Swann JR, Wilson ID, Roques JR, Darr DB, Bailey ST, Montgomery SA, Roach JM, Azcarate-Peril MA, ... ... Redinbo MR, et al. Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy. Proceedings of the National Academy of Sciences of the United States of America. PMID 32170007 DOI: 10.1073/Pnas.1918095117 |
0.719 |
|
2020 |
Bartolini D, De Franco F, Torquato P, Marinelli R, Cerra B, Ronchetti R, Schön A, Fallarino F, De Luca A, Bellezza G, Ferri I, Sidoni A, Walton WG, Pellock SJ, Redinbo MR, et al. Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor. Journal of Medicinal Chemistry. PMID 32160459 DOI: 10.1021/Acs.Jmedchem.0C00012.S001 |
0.339 |
|
2020 |
Dvořák Z, Kopp F, Costello CM, Kemp JS, Li H, Vrzalová A, Štěpánková M, Bartoňková I, Jiskrová E, Poulíková K, Vyhlídalová B, Nordstroem LU, Karunaratne CV, Ranhotra HS, Mun KS, ... ... Redinbo MR, et al. Targeting the pregnane X receptor using microbial metabolite mimicry. Embo Molecular Medicine. e11621. PMID 32153125 DOI: 10.15252/Emmm.201911621 |
0.385 |
|
2020 |
Redinbo M. Abstract IA01: Molecular control of the gut microbiome to improve cancer chemotherapy Cancer Research. 80. DOI: 10.1158/1538-7445.Mvc2020-Ia01 |
0.353 |
|
2019 |
Jariwala PB, Pellock SJ, Goldfarb D, Cloer EW, Artola M, Simpson JB, Bhatt AP, Walton WG, Roberts LR, Major MB, Davies GJ, Overkleeft HS, Redinbo MR. Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling. Acs Chemical Biology. PMID 31774274 DOI: 10.1021/Acschembio.9B00788 |
0.39 |
|
2019 |
Ervin SM, Hanley RP, Lim L, Walton WG, Pearce KH, Bhatt AP, James LI, Redinbo MR. Targeting regorafenib-induced toxicity through inhibition of gut microbial β-glucuronidases. Acs Chemical Biology. PMID 31663730 DOI: 10.1021/Acschembio.9B00663 |
0.383 |
|
2019 |
Ervin SM, Li H, Lim L, Roberts LR, Liang X, Mani S, Redinbo MR. Gut microbiome-derived β-glucuronidases are components of the estrobolome that reactivate estrogens. The Journal of Biological Chemistry. PMID 31636122 DOI: 10.1074/Jbc.Ra119.010950 |
0.378 |
|
2019 |
Pellock SJ, Walton WG, Redinbo MR. Selecting a Single Stereocenter: The Molecular Nuances that Differentiate β-Hexuronidases in the Human Gut Microbiome. Biochemistry. PMID 30729778 DOI: 10.2210/Pdb6Ncw/Pdb |
0.42 |
|
2019 |
Biernat KA, Pellock SJ, Bhatt AP, Bivins MM, Walton WG, Tran BNT, Wei L, Snider MC, Cesmat AP, Tripathy A, Erie DA, Redinbo MR. Structure, function, and inhibition of drug reactivating human gut microbial β-glucuronidases. Scientific Reports. 9: 825. PMID 30696850 DOI: 10.1038/s41598-018-36069-w |
0.638 |
|
2019 |
Pellock SJ, Walton WG, Ervin SM, Torres-Rivera D, Creekmore BC, Bergan G, Dunn ZD, Li B, Tripathy A, Redinbo MR. Discovery and Characterization of FMN-Binding β-Glucuronidases in the Human Gut Microbiome. Journal of Molecular Biology. PMID 30658055 DOI: 10.1016/J.Jmb.2019.01.013 |
0.43 |
|
2019 |
Biernat KA, Pellock SJ, Bhatt AP, Bivins MM, Walton WG, Tran BNT, Wei L, Snider MC, Cesmat AP, Tripathy A, Erie DA, Redinbo MR. Structure, function, and inhibition of drug reactivating human gut microbial beta-glucuronidases. Scientific Reports. 9: 825-825. DOI: 10.2210/Pdb6Ed2/Pdb |
0.671 |
|
2018 |
Shapiro JA, Varga JJ, Parsonage D, Walton W, Redinbo MR, Ross LJ, White EL, Bostwick R, Wuest WM, Claiborne A, Goldberg JB. Identification of Specific and Non-specific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK). Chemmedchem. PMID 30376607 DOI: 10.1002/Cmdc.201800652 |
0.309 |
|
2018 |
Pellock SJ, Walton WG, Biernat KA, Torres-Rivera D, Creekmore BC, Xu Y, Liu J, Tripathy A, Stewart LJ, Redinbo MR. . The Journal of Biological Chemistry. PMID 30301767 DOI: 10.1074/Jbc.Ra118.005414 |
0.446 |
|
2018 |
Little MS, Ervin SM, Walton WG, Tripathy A, Xu Y, Liu J, Redinbo MR. Active Site Flexibility Revealed in Crystal Structures of Parabacteroides merdae β-Glucuronidase from the Human Gut Microbiome. Protein Science : a Publication of the Protein Society. PMID 30230652 DOI: 10.1002/Pro.3507 |
0.434 |
|
2018 |
Pellock SJ, Creekmore BC, Walton WG, Mehta N, Biernat KA, Cesmat AP, Ariyarathna Y, Dunn ZD, Li B, Jin J, James LI, Redinbo MR. Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception. Acs Central Science. 4: 868-879. PMID 30062115 DOI: 10.1021/Acscentsci.8B00239 |
0.389 |
|
2018 |
Little MS, Redinbo MR. Crystal structure of the mouse innate immunity factor bacterial permeability-increasing family member A1. Acta Crystallographica. Section F, Structural Biology Communications. 74: 268-276. PMID 29717993 DOI: 10.1107/S2053230X18004600 |
0.349 |
|
2017 |
Little MS, Pellock SJ, Walton WG, Tripathy A, Redinbo MR. Structural basis for the regulation of β-glucuronidase expression by human gut Enterobacteriaceae. Proceedings of the National Academy of Sciences of the United States of America. PMID 29269393 DOI: 10.1073/Pnas.1716241115 |
0.479 |
|
2017 |
Pollet RM, D'Agostino EH, Walton WG, Xu Y, Little MS, Biernat KA, Pellock SJ, Patterson LM, Creekmore BC, Isenberg HN, Bahethi RR, Bhatt AP, Liu J, Gharaibeh RZ, Redinbo MR. An Atlas of β-Glucuronidases in the Human Intestinal Microbiome. Structure (London, England : 1993). PMID 28578872 DOI: 10.1016/J.Str.2017.05.003 |
0.785 |
|
2017 |
Pellock SJ, Redinbo MR. Glucuronides in the Gut: Sugar-Driven Symbioses Between Microbe and Host. The Journal of Biological Chemistry. PMID 28389557 DOI: 10.1074/Jbc.R116.767434 |
0.33 |
|
2017 |
Yu AM, Ingelman-Sundberg M, Cherrington NJ, Aleksunes LM, Zanger UM, Xie W, Jeong H, Morgan EM, Turnbaugh PJ, Klaassen CD, Bhatt AP, Redinbo MR, Hao P, Waxman DJ, Wang L, et al. Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21(st) International Symposium on Microsomes and Drug Oxidations (MDO). Acta Pharmaceutica Sinica. B. 7: 241-248. PMID 28388695 DOI: 10.1016/J.Apsb.2016.12.006 |
0.308 |
|
2017 |
Bellendir SP, Rognstad DJ, Morris LP, Zapotoczny G, Walton WG, Redinbo MR, Ramsden DA, Sekelsky J, Erie DA. Substrate preference of Gen endonucleases highlights the importance of branched structures as DNA damage repair intermediates. Nucleic Acids Research. PMID 28369583 DOI: 10.1093/Nar/Gkx214 |
0.663 |
|
2017 |
Redinbo MR. Microbial Molecules from the Multitudes within Us. Cell Metabolism. 25: 230-232. PMID 28178564 DOI: 10.1016/J.Cmet.2017.01.013 |
0.34 |
|
2016 |
Walton WG, Ahmad S, Little MR, Kim CS, Tyrrell JS, Lin Q, Di YP, Tarran R, Redinbo MR. Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1. Biochemistry. PMID 27145151 DOI: 10.1021/Acs.Biochem.6B00271 |
0.388 |
|
2016 |
Ghodge SV, Biernat KA, Bassett SJ, Redinbo MR, Bowers AA. Post-Translational Claisen Condensation and Decarboxylation en Route to the Bicyclic Core of Pantocin A. Journal of the American Chemical Society. PMID 27088303 DOI: 10.1021/Jacs.5B13529 |
0.33 |
|
2016 |
Pollet RM, Ingle JD, Hymes JP, Eakes TC, Eto KY, Kwong SM, Ramsay JP, Firth N, Redinbo MR. Processing of Non-Conjugative Resistance Plasmids by Conjugation Nicking Enzyme of Staphylococci. Journal of Bacteriology. PMID 26728193 DOI: 10.1128/Jb.00832-15 |
0.793 |
|
2015 |
Wallace BD, Roberts AB, Pollet RM, Ingle JD, Biernat KA, Pellock SJ, Venkatesh MK, Guthrie L, O'Neal SK, Robinson SJ, Dollinger M, Figueroa E, McShane SR, Cohen RD, Jin J, ... ... Redinbo MR, et al. Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. Chemistry & Biology. 22: 1238-49. PMID 26364932 DOI: 10.1016/J.Chembiol.2015.08.005 |
0.787 |
|
2015 |
Pollet R, Wallace B, Robers A, Boelsterli U, Mani S, Redinbo M. Pharmaceutical Control of the Microbiome The Faseb Journal. 29. DOI: 10.1096/Fasebj.29.1_Supplement.575.13 |
0.771 |
|
2014 |
McLaughlin KJ, Nash RP, Redinbo MR. Unique helicase determinants in the essential conjugative TraI factor from Salmonella enterica serovar Typhimurium plasmid pCU1. Journal of Bacteriology. 196: 3082-90. PMID 24936053 DOI: 10.1128/Jb.01496-14 |
0.795 |
|
2014 |
Mani S, Boelsterli UA, Redinbo MR. Understanding and modulating mammalian-microbial communication for improved human health. Annual Review of Pharmacology and Toxicology. 54: 559-80. PMID 24160697 DOI: 10.1146/Annurev-Pharmtox-011613-140007 |
0.332 |
|
2014 |
Saitta KS, Zhang C, Lee KK, Fujimoto K, Redinbo MR, Boelsterli UA. Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 44: 28-35. PMID 23829165 DOI: 10.3109/00498254.2013.811314 |
0.306 |
|
2013 |
Hobbs CA, Blanchard MG, Alijevic O, Tan CD, Kellenberger S, Bencharit S, Cao R, Kesimer M, Walton WG, Henderson AG, Redinbo MR, Stutts MJ, Tarran R. Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. American Journal of Physiology. Lung Cellular and Molecular Physiology. 305: L990-L1001. PMID 24124190 DOI: 10.1152/Ajplung.00103.2013 |
0.618 |
|
2013 |
Garland AL, Walton WG, Coakley RD, Tan CD, Gilmore RC, Hobbs CA, Tripathy A, Clunes LA, Bencharit S, Stutts MJ, Betts L, Redinbo MR, Tarran R. Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways. Proceedings of the National Academy of Sciences of the United States of America. 110: 15973-8. PMID 24043776 DOI: 10.1073/Pnas.1311999110 |
0.581 |
|
2013 |
Cheng Y, Johnson MD, Burillo-Kirch C, Mocny JC, Anderson JE, Garrett CK, Redinbo MR, Thomas CE. Mutation of the conserved calcium-binding motif in Neisseria gonorrhoeae PilC1 impacts adhesion but not piliation. Infection and Immunity. 81: 4280-9. PMID 24002068 DOI: 10.1128/Iai.00493-13 |
0.565 |
|
2013 |
Marden JN, Diaz MR, Walton WG, Gode CJ, Betts L, Urbanowski ML, Redinbo MR, Yahr TL, Wolfgang MC. An unusual CsrA family member operates in series with RsmA to amplify posttranscriptional responses in Pseudomonas aeruginosa. Proceedings of the National Academy of Sciences of the United States of America. 110: 15055-60. PMID 23980177 DOI: 10.1073/Pnas.1307217110 |
0.329 |
|
2013 |
Roberts AB, Wallace BD, Venkatesh MK, Mani S, Redinbo MR. Molecular insights into microbial β-glucuronidase inhibition to abrogate CPT-11 toxicity. Molecular Pharmacology. 84: 208-17. PMID 23690068 DOI: 10.1124/Mol.113.085852 |
0.744 |
|
2013 |
Wallace BD, Redinbo MR. The human microbiome is a source of therapeutic drug targets. Current Opinion in Chemical Biology. 17: 379-84. PMID 23680493 DOI: 10.1016/J.Cbpa.2013.04.011 |
0.729 |
|
2013 |
Hobbs CA, Blanchard MG, Kellenberger S, Bencharit S, Cao R, Kesimer M, Walton WG, Redinbo MR, Stutts MJ, Tarran R. Erratum: Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways (FASEB Journal (2012) 26 (4348-4359) doi:10.1096/fj.12-207431) The Faseb Journal. 27. PMID 23632283 DOI: 10.1096/Fj.12-207431Ret |
0.58 |
|
2013 |
Wallace BD, Betts L, Talmage G, Pollet RM, Holman NS, Redinbo MR. Structural and functional analysis of the human nuclear xenobiotic receptor PXR in complex with RXRα. Journal of Molecular Biology. 425: 2561-77. PMID 23602807 DOI: 10.1016/J.Jmb.2013.04.012 |
0.809 |
|
2013 |
Li H, Redinbo MR, Venkatesh M, Ekins S, Chaudhry A, Bloch N, Negassa A, Mukherjee P, Kalpana G, Mani S. Novel yeast-based strategy unveils antagonist binding regions on the nuclear xenobiotic receptor PXR. The Journal of Biological Chemistry. 288: 13655-68. PMID 23525103 DOI: 10.1074/Jbc.M113.455485 |
0.377 |
|
2013 |
Edwards JS, Betts L, Frazier ML, Pollet RM, Kwong SM, Walton WG, Ballentine WK, Huang JJ, Habibi S, Del Campo M, Meier JL, Dervan PB, Firth N, Redinbo MR. Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America. 110: 2804-9. PMID 23359708 DOI: 10.1073/Pnas.1219701110 |
0.81 |
|
2013 |
Mani S, Dou W, Redinbo MR. PXR antagonists and implication in drug metabolism. Drug Metabolism Reviews. 45: 60-72. PMID 23330542 DOI: 10.3109/03602532.2012.746363 |
0.325 |
|
2013 |
Porsch EA, Johnson MD, Broadnax AD, Garrett CK, Redinbo MR, St Geme JW. Calcium binding properties of the Kingella kingae PilC1 and PilC2 proteins have differential effects on type IV pilus-mediated adherence and twitching motility. Journal of Bacteriology. 195: 886-95. PMID 23243304 DOI: 10.1128/Jb.02186-12 |
0.499 |
|
2013 |
Wallace BD, Redinbo MR. Xenobiotic-sensing nuclear receptors involved in drug metabolism: a structural perspective. Drug Metabolism Reviews. 45: 79-100. PMID 23210723 DOI: 10.3109/03602532.2012.740049 |
0.735 |
|
2012 |
Wallace BD, Edwards JS, Wallen JR, Moolman WJ, van der Westhuyzen R, Strauss E, Redinbo MR, Claiborne A. Turnover-dependent covalent inactivation of Staphylococcus aureus coenzyme A-disulfide reductase by coenzyme A-mimetics: mechanistic and structural insights. Biochemistry. 51: 7699-711. PMID 22954034 DOI: 10.1021/Bi301026C |
0.801 |
|
2012 |
Hobbs CA, Blanchard MG, Kellenberger S, Bencharit S, Cao R, Kesimer M, Walton WG, Redinbo MR, Stutts MJ, Tarran R. Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4348-59. PMID 22798424 DOI: 10.1096/Fj.12-207431 |
0.597 |
|
2012 |
Nash RP, McNamara DE, Ballentine WK, Matson SW, Redinbo MR. Investigating the impact of bisphosphonates and structurally related compounds on bacteria containing conjugative plasmids. Biochemical and Biophysical Research Communications. 424: 697-703. PMID 22796221 DOI: 10.1016/J.Bbrc.2012.07.012 |
0.752 |
|
2012 |
LoGuidice A, Wallace BD, Bendel L, Redinbo MR, Boelsterli UA. Pharmacologic targeting of bacterial β-glucuronidase alleviates nonsteroidal anti-inflammatory drug-induced enteropathy in mice. The Journal of Pharmacology and Experimental Therapeutics. 341: 447-54. PMID 22328575 DOI: 10.1124/Jpet.111.191122 |
0.718 |
|
2012 |
Navaratnarajah P, Steele BL, Redinbo MR, Thompson NL. Rifampicin-independent interactions between the pregnane X receptor ligand binding domain and peptide fragments of coactivator and corepressor proteins. Biochemistry. 51: 19-31. PMID 22185585 DOI: 10.1016/J.Bpj.2011.11.1055 |
0.357 |
|
2012 |
Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, Redinbo MR. Correction: Nerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme Plos One. 7. DOI: 10.1371/Annotation/C5953F27-95F8-4A1B-A46C-639D90E182Ac |
0.552 |
|
2011 |
Johnson MD, Garrett CK, Bond JE, Coggan KA, Wolfgang MC, Redinbo MR. Pseudomonas aeruginosa PilY1 binds integrin in an RGD- and calcium-dependent manner. Plos One. 6: e29629. PMID 22242136 DOI: 10.1371/Journal.Pone.0029629 |
0.506 |
|
2011 |
Cheng Y, Frazier M, Lu F, Cao X, Redinbo MR. Crystal structure of the plant epigenetic protein arginine methyltransferase 10. Journal of Molecular Biology. 414: 106-22. PMID 21986201 DOI: 10.1016/J.Jmb.2011.09.040 |
0.686 |
|
2011 |
Cheng Y, Redinbo MR. Activation of the human nuclear xenobiotic receptor PXR by the reverse transcriptase-targeted anti-HIV drug PNU-142721. Protein Science : a Publication of the Protein Society. 20: 1713-9. PMID 21805522 DOI: 10.1002/Pro.706 |
0.529 |
|
2011 |
Ahmad S, Hughes MA, Lane KT, Redinbo MR, Yeh LA, Scott JE. A High Throughput Assay for Discovery of Bacterial β-Glucuronidase Inhibitors. Current Chemical Genomics. 5: 13-20. PMID 21643506 DOI: 10.2174/1875397301105010013 |
0.338 |
|
2011 |
Edwards JS, Kumbhar A, Roberts A, Hemmert AC, Edwards CC, Potter PM, Redinbo MR. Immobilization of active human carboxylesterase 1 in biomimetic silica nanoparticles. Biotechnology Progress. 27: 863-9. PMID 21509954 DOI: 10.1002/Btpr.604 |
0.573 |
|
2011 |
Hemmert AC, Otto TC, Chica RA, Wierdl M, Edwards JS, Lewis SM, Lewis SL, Edwards CC, Tsurkan L, Cadieux CL, Kasten SA, Cashman JR, Mayo SL, Potter PM, Cerasoli DM, ... Redinbo MR, et al. Nerve agent hydrolysis activity designed into a human drug metabolism enzyme. Plos One. 6: e17441. PMID 21445272 DOI: 10.1371/Journal.Pone.0017441 |
0.604 |
|
2011 |
Nash RP, Niblock FC, Redinbo MR. Tyrosine partners coordinate DNA nicking by the Salmonella typhimurium plasmid pCU1 relaxase enzyme. Febs Letters. 585: 1216-22. PMID 21439279 DOI: 10.1016/J.Febslet.2011.03.043 |
0.779 |
|
2011 |
Lomino JV, Tripathy A, Redinbo MR. Triggered Mycobacterium tuberculosis heparin-binding hemagglutinin adhesin folding and dimerization. Journal of Bacteriology. 193: 2089-96. PMID 21398546 DOI: 10.1128/Jb.01231-10 |
0.786 |
|
2011 |
Cheng Y, McNamara DE, Miley MJ, Nash RP, Redinbo MR. Functional characterization of the multidomain F plasmid TraI relaxase-helicase. The Journal of Biological Chemistry. 286: 12670-82. PMID 21288910 DOI: 10.1074/Jbc.M110.207563 |
0.796 |
|
2011 |
Navaratnarajah P, Steele BL, Redinbo MR, Thompson NL. Nuclear Receptor (PXR), Ligand and Co-Activator Interactions Measured by Total Internal Reflection Fluorescence Microscopy Biophysical Journal. 100: 618a. DOI: 10.1016/J.Bpj.2010.12.3558 |
0.347 |
|
2010 |
Wallace BD, Wang H, Lane KT, Scott JE, Orans J, Koo JS, Venkatesh M, Jobin C, Yeh LA, Mani S, Redinbo MR. Alleviating cancer drug toxicity by inhibiting a bacterial enzyme. Science (New York, N.Y.). 330: 831-5. PMID 21051639 DOI: 10.1126/Science.1191175 |
0.794 |
|
2010 |
Parsonage D, Newton GL, Holder RC, Wallace BD, Paige C, Hamilton CJ, Dos Santos PC, Redinbo MR, Reid SD, Claiborne A. Characterization of the N-acetyl-α-D-glucosaminyl l-malate synthase and deacetylase functions for bacillithiol biosynthesis in Bacillus anthracis . Biochemistry. 49: 8398-414. PMID 20799687 DOI: 10.1021/Bi100698N |
0.733 |
|
2010 |
Nash RP, Habibi S, Cheng Y, Lujan SA, Redinbo MR. The mechanism and control of DNA transfer by the conjugative relaxase of resistance plasmid pCU1. Nucleic Acids Research. 38: 5929-43. PMID 20448025 DOI: 10.1093/Nar/Gkq303 |
0.809 |
|
2010 |
Orans J, Johnson MD, Coggan KA, Sperlazza JR, Heiniger RW, Wolfgang MC, Redinbo MR. Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility. Proceedings of the National Academy of Sciences of the United States of America. 107: 1065-70. PMID 20080557 DOI: 10.1073/Pnas.0911616107 |
0.788 |
|
2010 |
Hemmert AC, Otto TC, Wierdl M, Edwards CC, Fleming CD, MacDonald M, Cashman JR, Potter PM, Cerasoli DM, Redinbo MR. Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin. Molecular Pharmacology. 77: 508-16. PMID 20051531 DOI: 10.1124/Mol.109.062356 |
0.758 |
|
2010 |
Radominska-Pandya A, Bratton SM, Redinbo MR, Miley MJ. The crystal structure of human UDP-glucuronosyltransferase 2B7 C-terminal end is the first mammalian UGT target to be revealed: the significance for human UGTs from both the 1A and 2B families. Drug Metabolism Reviews. 42: 133-44. PMID 19821783 DOI: 10.3109/03602530903209049 |
0.425 |
|
2010 |
Hemmert AC, Redinbo MR. A structural examination of agrochemical processing by human carboxylesterase 1 Journal of Pesticide Science. 35: 250-256. DOI: 10.1584/Jpestics.R10-05 |
0.442 |
|
2010 |
Orans J, Johnson MDL, Coggan KA, Sperlazza JR, Heiniger RW, Wolfgang MC, Redinbo MR. Crystal structure analysis reveals Pseudomonas PilY1 as an essential calcium-dependent regulator of bacterial surface motility (Proceedings of the National Academy of Sciences of the United States of America (2010) 107, 3 (1065-1070) DOI:10.1073/pnas.0911616107) Proceedings of the National Academy of Sciences of the United States of America. 107: 5260. DOI: 10.1073/Pnas.1000441107 |
0.759 |
|
2009 |
Ekins S, Kortagere S, Iyer M, Reschly EJ, Lill MA, Redinbo MR, Krasowski MD. Challenges predicting ligand-receptor interactions of promiscuous proteins: the nuclear receptor PXR. Plos Computational Biology. 5: e1000594. PMID 20011107 DOI: 10.1371/Journal.Pcbi.1000594 |
0.379 |
|
2009 |
Kennedy SA, Frazier ML, Steiniger M, Mast AM, Marzluff WF, Redinbo MR. Crystal structure of the HEAT domain from the Pre-mRNA processing factor Symplekin. Journal of Molecular Biology. 392: 115-28. PMID 19576221 DOI: 10.1016/J.Jmb.2009.06.062 |
0.722 |
|
2009 |
Biswas A, Mani S, Redinbo MR, Krasowski MD, Li H, Ekins S. Elucidating the 'Jekyll and Hyde' nature of PXR: the case for discovering antagonists or allosteric antagonists. Pharmaceutical Research. 26: 1807-15. PMID 19415465 DOI: 10.1007/S11095-009-9901-7 |
0.314 |
|
2009 |
Guogas LM, Kennedy SA, Lee JH, Redinbo MR. A novel fold in the TraI relaxase-helicase c-terminal domain is essential for conjugative DNA transfer. Journal of Molecular Biology. 386: 554-68. PMID 19136009 DOI: 10.1016/J.Jmb.2008.12.057 |
0.667 |
|
2008 |
Teotico DG, Bischof JJ, Peng L, Kliewer SA, Redinbo MR. Structural basis of human pregnane X receptor activation by the hops constituent colupulone. Molecular Pharmacology. 74: 1512-20. PMID 18768384 DOI: 10.1124/Mol.108.050732 |
0.44 |
|
2008 |
Teotico DG, Frazier ML, Ding F, Dokholyan NV, Temple BR, Redinbo MR. Active nuclear receptors exhibit highly correlated AF-2 domain motions. Plos Computational Biology. 4: e1000111. PMID 18617990 DOI: 10.1371/Journal.Pcbi.1000111 |
0.601 |
|
2008 |
Potts RG, Lujan SA, Redinbo MR. Winning the asymmetric war: new strategies for combating antibacterial resistance. Future Microbiology. 3: 119-23. PMID 18366330 DOI: 10.2217/17460913.3.2.119 |
0.667 |
|
2008 |
Schaaf G, Ortlund EA, Tyeryar KR, Mousley CJ, Ile KE, Garrett TA, Ren J, Woolls MJ, Raetz CR, Redinbo MR, Bankaitis VA. Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily. Molecular Cell. 29: 191-206. PMID 18243114 DOI: 10.1016/J.Molcel.2007.11.026 |
0.608 |
|
2008 |
Wierdl M, Tsurkan L, Hyatt JL, Edwards CC, Hatfield MJ, Morton CL, Houghton PJ, Danks MK, Redinbo MR, Potter PM. An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11. Cancer Gene Therapy. 15: 183-92. PMID 18188187 DOI: 10.1038/Sj.Cgt.7701112 |
0.349 |
|
2008 |
Wang H, Li H, Moore LB, Johnson MD, Maglich JM, Goodwin B, Ittoop OR, Wisely B, Creech K, Parks DJ, Collins JL, Willson TM, Kalpana GV, Venkatesh M, Xie W, ... ... Redinbo M, et al. The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor. Molecular Endocrinology (Baltimore, Md.). 22: 838-57. PMID 18096694 DOI: 10.1210/Me.2007-0218 |
0.569 |
|
2008 |
Xiong Y, Patana AS, Miley MJ, Zielinska AK, Bratton SM, Miller GP, Goldman A, Finel M, Redinbo MR, Radominska-Pandya A. The first aspartic acid of the DQxD motif for human UDP-glucuronosyltransferase 1A10 interacts with UDP-glucuronic acid during catalysis. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 517-22. PMID 18048489 DOI: 10.1124/Dmd.107.016469 |
0.371 |
|
2007 |
Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW. Crystal structure of an ancient protein: evolution by conformational epistasis. Science (New York, N.Y.). 317: 1544-8. PMID 17702911 DOI: 10.1126/Science.1142819 |
0.626 |
|
2007 |
Lujan SA, Guogas LM, Ragonese H, Matson SW, Redinbo MR. Disrupting antibiotic resistance propagation by inhibiting the conjugative DNA relaxase. Proceedings of the National Academy of Sciences of the United States of America. 104: 12282-7. PMID 17630285 DOI: 10.1073/Pnas.0702760104 |
0.724 |
|
2007 |
Miley MJ, Zielinska AK, Keenan JE, Bratton SM, Radominska-Pandya A, Redinbo MR. Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7. Journal of Molecular Biology. 369: 498-511. PMID 17442341 DOI: 10.1016/J.Jmb.2007.03.066 |
0.428 |
|
2007 |
Wang H, Huang H, Li H, Teotico DG, Sinz M, Baker SD, Staudinger J, Kalpana G, Redinbo MR, Mani S. Activated pregnenolone X-receptor is a target for ketoconazole and its analogs. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 2488-95. PMID 17438109 DOI: 10.1158/1078-0432.Ccr-06-1592 |
0.404 |
|
2007 |
Fleming CD, Edwards CC, Kirby SD, Maxwell DM, Potter PM, Cerasoli DM, Redinbo MR. Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun. Biochemistry. 46: 5063-71. PMID 17407327 DOI: 10.1021/Bi700246N |
0.785 |
|
2007 |
Xue Y, Moore LB, Orans J, Peng L, Bencharit S, Kliewer SA, Redinbo MR. Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition. Molecular Endocrinology (Baltimore, Md.). 21: 1028-38. PMID 17327420 DOI: 10.1210/Me.2006-0323 |
0.801 |
|
2007 |
Xue Y, Chao E, Zuercher WJ, Willson TM, Collins JL, Redinbo MR. Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism. Bioorganic & Medicinal Chemistry. 15: 2156-66. PMID 17215127 DOI: 10.1016/J.Bmc.2006.12.026 |
0.404 |
|
2007 |
Wadkins RM, Hyatt JL, Edwards CC, Tsurkan L, Redinbo MR, Wheelock CE, Jones PD, Hammock BD, Potter PM. Analysis of mammalian carboxylesterase inhibition by trifluoromethylketone-containing compounds. Molecular Pharmacology. 71: 713-23. PMID 17167034 DOI: 10.1124/Mol.105.021683 |
0.35 |
|
2007 |
Huang H, Wang H, Sinz M, Zoeckler M, Staudinger J, Redinbo MR, Teotico DG, Locker J, Kalpana GV, Mani S. Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole. Oncogene. 26: 258-68. PMID 16819505 DOI: 10.1038/Sj.Onc.1209788 |
0.357 |
|
2007 |
Xue Y, Moore LB, Orans J, Peng L, Bencharit S, Kliewer SA, Redinbo MR. Erratum: Crystal structure of the pregnane X receptor-estradiol complex provides insights into endobiotic recognition (Molecular Endocrinology (2007) 21, 5, (1028-1038)) Molecular Endocrinology. 21: 1488-1489. DOI: 10.1210/Me.2007-0000 |
0.784 |
|
2006 |
Bencharit S, Edwards CC, Morton CL, Howard-Williams EL, Kuhn P, Potter PM, Redinbo MR. Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1. Journal of Molecular Biology. 363: 201-14. PMID 16962139 DOI: 10.1016/J.Jmb.2006.08.025 |
0.674 |
|
2006 |
Noble SM, Carnahan VE, Moore LB, Luntz T, Wang H, Ittoop OR, Stimmel JB, Davis-Searles PR, Watkins RE, Wisely GB, LeCluyse E, Tripathy A, McDonnell DP, Redinbo MR. Human PXR forms a tryptophan zipper-mediated homodimer. Biochemistry. 45: 8579-89. PMID 16834332 DOI: 10.1021/Bi0602821 |
0.693 |
|
2006 |
Wierdl M, Wadkins R, Redinbo M, Tsurkan L, Potter P. 655. Development of a Human Carboxylesterase That Can Efficiently Metabolize CPT-11 Molecular Therapy. 13: S252. DOI: 10.1016/J.Ymthe.2006.08.731 |
0.347 |
|
2005 |
Solomon IH, Hager JM, Safi R, McDonnell DP, Redinbo MR, Ortlund EA. Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. Journal of Molecular Biology. 354: 1091-102. PMID 16289203 DOI: 10.1016/J.Jmb.2005.10.009 |
0.655 |
|
2005 |
Ingraham HA, Redinbo MR. Orphan nuclear receptors adopted by crystallography. Current Opinion in Structural Biology. 15: 708-15. PMID 16263271 DOI: 10.1016/J.Sbi.2005.10.009 |
0.362 |
|
2005 |
Huang H, Fleming CD, Nishi K, Redinbo MR, Hammock BD. Stereoselective hydrolysis of pyrethroid-like fluorescent substrates by human and other mammalian liver carboxylesterases. Chemical Research in Toxicology. 18: 1371-7. PMID 16167828 DOI: 10.1021/Tx050072+ |
0.759 |
|
2005 |
Carnahan VE, Redinbo MR. Structure and function of the human nuclear xenobiotic receptor PXR. Current Drug Metabolism. 6: 357-67. PMID 16101574 DOI: 10.2174/1389200054633844 |
0.407 |
|
2005 |
Fleming CD, Bencharit S, Edwards CC, Hyatt JL, Tsurkan L, Bai F, Fraga C, Morton CL, Howard-Williams EL, Potter PM, Redinbo MR. Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. Journal of Molecular Biology. 352: 165-77. PMID 16081098 DOI: 10.1016/J.Jmb.2005.07.016 |
0.804 |
|
2005 |
Orans J, Teotico DG, Redinbo MR. The nuclear xenobiotic receptor pregnane X receptor: recent insights and new challenges. Molecular Endocrinology (Baltimore, Md.). 19: 2891-900. PMID 15961506 DOI: 10.1210/Me.2005-0156 |
0.78 |
|
2005 |
Redinbo MR, Potter PM. Mammalian carboxylesterases: from drug targets to protein therapeutics. Drug Discovery Today. 10: 313-25. PMID 15749280 DOI: 10.1016/S1359-6446(05)03383-0 |
0.373 |
|
2005 |
Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Nature Structural & Molecular Biology. 12: 357-63. PMID 15723037 DOI: 10.1038/Nsmb910 |
0.638 |
|
2005 |
Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, Redinbo MR. Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin. Molecular Endocrinology (Baltimore, Md.). 19: 1125-34. PMID 15705662 DOI: 10.1210/Me.2004-0346 |
0.803 |
|
2004 |
Antony S, Theruvathu JA, Brooks PJ, Lesher DT, Redinbo M, Pommier Y. Enhancement of camptothecin-induced topoisomerase I cleavage complexes by the acetaldehyde adduct N2-ethyl-2'-deoxyguanosine. Nucleic Acids Research. 32: 5685-92. PMID 15498925 DOI: 10.1093/nar/gkh902 |
0.785 |
|
2004 |
Chillemi G, Redinbo M, Bruselles A, Desideri A. Role of the linker domain and the 203-214 N-terminal residues in the human topoisomerase I DNA complex dynamics Biophysical Journal. 87: 4087-4097. PMID 15347588 DOI: 10.1529/Biophysj.104.044925 |
0.391 |
|
2004 |
Thapar R, Marzluff WF, Redinbo MR. Electrostatic contribution of serine phosphorylation to the Drosophila SLBP--histone mRNA complex. Biochemistry. 43: 9401-12. PMID 15260483 DOI: 10.1021/Bi036315J |
0.306 |
|
2004 |
Chrencik JE, Staker BL, Burgin AB, Pourquier P, Pommier Y, Stewart L, Redinbo MR. Mechanisms of camptothecin resistance by human topoisomerase I mutations. Journal of Molecular Biology. 339: 773-84. PMID 15165849 DOI: 10.1016/J.Jmb.2004.03.077 |
0.796 |
|
2004 |
Wierdl M, Morton CL, Nguyen NK, Redinbo MR, Potter PM. Molecular modeling of CPT-11 metabolism by carboxylesterases (CEs): use of pnb CE as a model. Biochemistry. 43: 1874-82. PMID 14967028 DOI: 10.1021/Bi035586R |
0.357 |
|
2003 |
Watkins RE, Davis-Searles PR, Lambert MH, Redinbo MR. Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor. Journal of Molecular Biology. 331: 815-28. PMID 12909012 DOI: 10.1016/S0022-2836(03)00795-2 |
0.415 |
|
2003 |
Redinbo MR, Bencharit S, Potter PM. Human carboxylesterase 1: from drug metabolism to drug discovery. Biochemical Society Transactions. 31: 620-4. PMID 12773168 DOI: 10.1042/Bst0310620 |
0.65 |
|
2003 |
Bencharit S, Morton CL, Hyatt JL, Kuhn P, Danks MK, Potter PM, Redinbo MR. Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition. Chemistry & Biology. 10: 341-9. PMID 12725862 DOI: 10.1016/S1074-5521(03)00071-1 |
0.686 |
|
2003 |
Bencharit S, Morton CL, Xue Y, Potter PM, Redinbo MR. Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. Nature Structural Biology. 10: 349-56. PMID 12679808 DOI: 10.1038/Nsb919 |
0.655 |
|
2003 |
Watkins RE, Maglich JM, Moore LB, Wisely GB, Noble SM, Davis-Searles PR, Lambert MH, Kliewer SA, Redinbo MR. 2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin. Biochemistry. 42: 1430-8. PMID 12578355 DOI: 10.1021/Bi0268753 |
0.704 |
|
2003 |
Chrencik JE, Burgin AB, Pommier Y, Stewart L, Redinbo MR. Structural impact of the leukemia drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the covalent human topoisomerase I-DNA complex. The Journal of Biological Chemistry. 278: 12461-6. PMID 12533542 DOI: 10.1074/Jbc.M212930200 |
0.783 |
|
2002 |
Lesher DT, Pommier Y, Stewart L, Redinbo MR. 8-Oxoguanine rearranges the active site of human topoisomerase I. Proceedings of the National Academy of Sciences of the United States of America. 99: 12102-7. PMID 12209008 DOI: 10.1073/Pnas.192282699 |
0.807 |
|
2002 |
Bencharit S, Morton CL, Howard-Williams EL, Danks MK, Potter PM, Redinbo MR. Structural insights into CPT-11 activation by mammalian carboxylesterases. Nature Structural Biology. 9: 337-42. PMID 11967565 DOI: 10.1038/Nsb790 |
0.661 |
|
2002 |
Watkins RE, Noble SM, Redinbo MR. Structural insights into the promiscuity and function of the human pregnane X receptor. Current Opinion in Drug Discovery & Development. 5: 150-8. PMID 11865669 |
0.688 |
|
2002 |
Xue Y, Ratcliff GC, Wang H, Davis-Searles PR, Gray MD, Erie DA, Redinbo MR. A minimal exonuclease domain of WRN forms a hexamer on DNA and possesses both 3'- 5' exonuclease and 5'-protruding strand endonuclease activities. Biochemistry. 41: 2901-12. PMID 11863428 DOI: 10.1021/Bi0157161 |
0.648 |
|
2002 |
Goodwin B, Redinbo MR, Kliewer SA. Regulation of cyp3a gene transcription by the pregnane x receptor. Annual Review of Pharmacology and Toxicology. 42: 1-23. PMID 11807162 DOI: 10.1146/Annurev.Pharmtox.42.111901.111051 |
0.355 |
|
2002 |
Redinbo MR, Watkins RE, Noble SN, Wisely GB, Moore LB, Maglich JM, Kliewer SA. Front-line drug recognition in humans by the nuclear receptor PXR Acta Crystallographica Section a Foundations of Crystallography. 58: c201-c201. DOI: 10.1107/S0108767302093054 |
0.309 |
|
2002 |
Lesher D, Pommier Y, Stewart L, Redinbo MR. Structural impact of 8-oxoguanine on human topoisomerase I Acta Crystallographica Section a Foundations of Crystallography. 58: c121-c121. DOI: 10.1107/S0108767302089869 |
0.333 |
|
2001 |
Watkins RE, Wisely GB, Moore LB, Collins JL, Lambert MH, Williams SP, Willson TM, Kliewer SA, Redinbo MR. The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity. Science (New York, N.Y.). 292: 2329-33. PMID 11408620 DOI: 10.1126/Science.1060762 |
0.422 |
|
2000 |
Redinbo MR, Champoux JJ, Hol WG. Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA. Biochemistry. 39: 6832-40. PMID 10841763 DOI: 10.1021/Bi992690T |
0.622 |
|
1999 |
Redinbo MR, Stewart L, Champoux JJ, Hol WG. Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures. Journal of Molecular Biology. 292: 685-96. PMID 10497031 DOI: 10.1006/Jmbi.1999.3065 |
0.61 |
|
1999 |
Diller DJ, Redinbo MR, Pohl E, Hol WG. A database method for automated map interpretation in protein crystallography. Proteins. 36: 526-41. PMID 10450094 DOI: 10.1002/(Sici)1097-0134(19990901)36:4<526::Aid-Prot16>3.0.Co;2-F |
0.541 |
|
1999 |
Diller DJ, Pohl E, Redinbo MR, Hovey BT, Hol WG. A rapid method for positioning small flexible molecules, nucleic acids, and large protein fragments in experimental electron density maps. Proteins. 36: 512-25. PMID 10450093 DOI: 10.1002/(Sici)1097-0134(19990901)36:4<512::Aid-Prot15>3.0.Co;2-V |
0.759 |
|
1999 |
Redinbo MR, Champoux JJ, Hol WG. Structural insights into the function of type IB topoisomerases. Current Opinion in Structural Biology. 9: 29-36. PMID 10047584 DOI: 10.1016/S0959-440X(99)80005-0 |
0.625 |
|
1998 |
Stewart L, Redinbo MR, Qiu X, Hol WG, Champoux JJ. A model for the mechanism of human topoisomerase I. Science (New York, N.Y.). 279: 1534-41. PMID 9488652 DOI: 10.1126/Science.279.5356.1534 |
0.623 |
|
1998 |
Redinbo MR, Stewart L, Kuhn P, Champoux JJ, Hol WG. Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science (New York, N.Y.). 279: 1504-13. PMID 9488644 DOI: 10.1126/Science.279.5356.1504 |
0.621 |
|
1996 |
Redinbo MR, Eide SM, Stone RL, Dixon JE, Yeates TO. Crystallization and preliminary structural analysis of Bacillus subtilis adenylosuccinate lyase, an enzyme implicated in infantile autism. Protein Science : a Publication of the Protein Society. 5: 786-8. PMID 8845770 DOI: 10.1002/Pro.5560050425 |
0.581 |
|
1996 |
Redinbo MR, Stewart L, Pohl E, Qiu X, Champoux JJ, Hol WGJ. Progress in the structure determination of a human topoisomerase I–DNA complex Acta Crystallographica Section a Foundations of Crystallography. 52: C159-C159. DOI: 10.1107/S0108767396092896 |
0.345 |
|
1994 |
Redinbo MR, Yeates TO, Merchant S. Plastocyanin: structural and functional analysis. Journal of Bioenergetics and Biomembranes. 26: 49-66. PMID 8027022 DOI: 10.1007/Bf00763219 |
0.691 |
|
1993 |
Redinbo MR, Yeates TO. Structure determination of plastocyanin from a specimen with a hemihedral twinning fraction of one-half. Acta Crystallographica. Section D, Biological Crystallography. 49: 375-80. PMID 15299512 DOI: 10.1107/S090744499300294X |
0.552 |
|
1993 |
Redinbo MR, Cascio D, Choukair MK, Rice D, Merchant S, Yeates TO. The 1.5-A crystal structure of plastocyanin from the green alga Chlamydomonas reinhardtii. Biochemistry. 32: 10560-7. PMID 8399201 DOI: 10.1021/Bi00091A005 |
0.673 |
|
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