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David Spring, Ph.D. - Publications

Affiliations: 
Chemistry University of Cambridge, Cambridge, England, United Kingdom 
Area:
Organic Chemistry
Website:
http://www-spring.ch.cam.ac.uk
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47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Pantelejevs T, Zuazua-Villar P, Koczy O, Counsell AJ, Walsh SJ, Robertson NS, Spring DR, Downs JA, Hyvönen M. A recombinant approach for stapled peptide discovery yields inhibitors of the RAD51 recombinase. Chemical Science. 14: 13915-13923. PMID 38075664 DOI: 10.1039/d3sc03331g  0.618
2022 Brear P, De Fusco C, Atkinson EL, Iegre J, Francis-Newton NJ, Venkitaraman AR, Hyvönen M, Spring DR. A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action. Rsc Medicinal Chemistry. 13: 1420-1426. PMID 36426237 DOI: 10.1039/d2md00161f  0.639
2022 Atkinson EL, Iegre J, D'Amore C, Brear P, Salvi M, Hyvönen M, Spring DR. Development of small cyclic peptides targeting the CK2α/β interface. Chemical Communications (Cambridge, England). 58: 4791-4794. PMID 35343996 DOI: 10.1039/d2cc00707j  0.619
2021 Iegre J, Atkinson EL, Brear PD, Cooper BM, Hyvönen M, Spring DR. Chemical probes targeting the kinase CK2: a journey outside the catalytic box. Organic & Biomolecular Chemistry. 19: 4380-4396. PMID 34037044 DOI: 10.1039/d1ob00257k  0.647
2021 Atkinson EL, Iegre J, Brear PD, Zhabina EA, Hyvönen M, Spring DR. Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study. Molecules (Basel, Switzerland). 26. PMID 33807474 DOI: 10.3390/molecules26071977  0.627
2020 Kidd SL, Fowler E, Reinhardt T, Compton T, Mateu N, Newman H, Bellini D, Talon R, McLoughlin J, Krojer T, Aimon A, Bradley A, Fairhead M, Brear P, Díaz-Sáez L, ... ... Spring DR, et al. Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion. Chemical Science. 11: 10792-10801. PMID 34094333 DOI: 10.1039/d0sc01232g  0.625
2020 Strizhak AV, Babii O, Afonin S, Bakanovich I, Pantelejevs T, Xu W, Fowler E, Eapen R, Sharma K, Platonov MO, Hurmach VV, Itzhaki L, Hyvönen M, Ulrich AS, Spring DR, et al. Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction. Organic & Biomolecular Chemistry. PMID 32390036 DOI: 10.1039/d0ob00831a  0.618
2019 Sharma P, Mahen R, Rossmann M, Stokes JE, Hardwick B, Huggins DJ, Emery A, Kunciw DL, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR. A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation. Scientific Reports. 9: 15930. PMID 31685831 DOI: 10.1038/S41598-019-50702-2  0.6
2019 Sharma K, Strizhak AV, Fowler E, Wang X, Xu W, Hatt Jensen C, Wu Y, Sore HF, Lau YH, Hyvönen M, Itzhaki LS, Spring DR. Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry. Organic & Biomolecular Chemistry. PMID 31418442 DOI: 10.1039/c9ob01745c  0.595
2019 Iegre J, Brear P, Baker DJ, Tan YS, Atkinson EL, Sore HF, O' Donovan DH, Verma CS, Hyvönen M, Spring DR. Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein-protein interaction. Chemical Science. 10: 5056-5063. PMID 31183056 DOI: 10.1039/c9sc00798a  0.643
2019 Walsh SJ, Omarjee S, Galloway WRJD, Kwan TT, Sore HF, Parker JS, Hyvönen M, Carroll JS, Spring DR. Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates. Chemical Science. 10: 633-634. PMID 30778404 DOI: 10.1039/c8sc90248h  0.591
2019 Walsh SJ, Omarjee S, Galloway WRJD, Kwan TT, Sore HF, Parker JS, Hyvönen M, Carroll JS, Spring DR. A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody-drug conjugates. Chemical Science. 10: 694-700. PMID 30774870 DOI: 10.1039/c8sc04645j  0.594
2018 Brear P, North A, Iegre J, Hadje Georgiou K, Lubin A, Carro L, Green W, Sore HF, Hyvönen M, Spring DR. Novel non-ATP competitive small molecules targeting the CK2 α/β interface. Bioorganic & Medicinal Chemistry. PMID 29759799 DOI: 10.1016/j.bmc.2018.05.011  0.622
2018 Iegre J, Brear P, De Fusco C, Yoshida M, Mitchell SL, Rossmann M, Carro L, Sore HF, Hyvönen M, Spring DR. Second-generation CK2α inhibitors targeting the αD pocket. Chemical Science. 9: 3041-3049. PMID 29732088 DOI: 10.1039/c7sc05122k  0.622
2017 Cole DJ, Janecek M, Stokes JE, Rossmann M, Faver JC, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR, Huggins DJ, Jorgensen WL. Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction. Chemical Communications (Cambridge, England). PMID 28787041 DOI: 10.1039/C7Cc05379G  0.61
2017 De Fusco C, Brear P, Iegre J, Georgiou KH, Sore HF, Hyvönen M, Spring DR. A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066. Bioorganic & Medicinal Chemistry. PMID 28495381 DOI: 10.1016/j.bmc.2017.04.037  0.639
2017 Ciardiello JJ, Stewart HL, Sore HF, Galloway WR, Spring DR. A novel complexity-to-diversity strategy for the diversity-oriented synthesis of structurally diverse and complex macrocycles from quinine. Bioorganic & Medicinal Chemistry. PMID 28283333 DOI: 10.1016/J.Bmc.2017.02.060  0.325
2017 Xu W, Lau YH, Fischer G, Tan YS, Chattopadhyay A, de la Roche M, Hyvonen M, Verma CS, Spring DR, Itzhaki LS. Macrocyclized extended peptides: Inhibiting the substrate-recognition domain of tankyrase. Journal of the American Chemical Society. PMID 28084734 DOI: 10.1021/jacs.6b10234  0.621
2016 Hodgkinson JT, Gross J, Baker YR, Spring DR, Welch M. A new Pseudomonas quinolone signal (PQS) binding partner: MexG. Chemical Science. 7: 2553-2562. PMID 28660026 DOI: 10.1039/C5Sc04197J  0.34
2016 Brear P, De Fusco C, Hadje Georgiou K, Francis-Newton NJ, Stubbs CJ, Sore HF, Venkitaraman AR, Abell C, Spring DR, Hyvönen M. Specific inhibition of CK2α from an anchor outside the active site. Chemical Science. 7: 6839-6845. PMID 28451126 DOI: 10.1039/C6Sc02335E  0.63
2016 Janeček M, Rossmann M, Sharma P, Emery A, Huggins DJ, Stockwell SR, Stokes JE, Tan YS, Almeida EG, Hardwick B, Narvaez AJ, Hyvönen M, Spring DR, McKenzie GJ, Venkitaraman AR. Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein-protein interaction with TPX2. Scientific Reports. 6: 28528. PMID 27339427 DOI: 10.1038/Srep28528  0.633
2015 Lau YH, Wu Y, Rossmann M, Tan BX, de Andrade P, Tan YS, Verma C, McKenzie GJ, Venkitaraman AR, Hyvönen M, Spring DR. Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides. Angewandte Chemie (International Ed. in English). 54: 15410-3. PMID 26768531 DOI: 10.1002/Anie.201508416  0.628
2015 Alanine TA, Galloway WR, Bartlett S, Ciardiello JJ, McGuire TM, Spring DR. Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen. Organic & Biomolecular Chemistry. PMID 26632452 DOI: 10.1039/C5Ob01784J  0.349
2014 Liu T, Liu X, Spring DR, Qian X, Cui J, Xu Z. Quantitatively mapping cellular viscosity with detailed organelle information via a designed PET fluorescent probe. Scientific Reports. 4: 5418. PMID 24957323 DOI: 10.1038/srep05418  0.672
2013 Liu T, Xu Z, Spring DR, Cui J. A lysosome-targetable fluorescent probe for imaging hydrogen sulfide in living cells. Organic Letters. 15: 2310-3. PMID 23614763 DOI: 10.1021/ol400973v  0.602
2012 Xu Z, Liu X, Pan J, Spring DR. Coumarin-derived transformable fluorescent sensor for Zn2+. Chemical Communications (Cambridge, England). 48: 4764-6. PMID 22472965 DOI: 10.1039/c2cc30963g  0.585
2012 Zheng S, Laraia L, O' Connor CJ, Sorrell D, Tan YS, Xu Z, Venkitaraman AR, Wu W, Spring DR. Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity. Organic & Biomolecular Chemistry. 10: 2590-3. PMID 22361895 DOI: 10.1039/c2ob25065a  0.6
2012 Cilibrizzi A, Isidro-Llobet A, Mateu N, Galloway WRJD, Spring DR. Novel phosphate derivatives as scaffolds for the preparation of synthetic phosphoserine-based peptides using the Fmoc/ t -Bu solid-phase strategy Synlett. 290-294. DOI: 10.1055/S-0031-1290119  0.614
2011 Xu Z, Spring DR, Yoon J. Fluorescent sensing and discrimination of ATP and ADP based on a unique sandwich assembly of pyrene-adenine-pyrene. Chemistry, An Asian Journal. 6: 2114-22. PMID 21506284 DOI: 10.1002/Asia.201100120  0.675
2011 Isidro-Llobet A, Murillo T, Bello P, Cilibrizzi A, Hodgkinson JT, Galloway WR, Bender A, Welch M, Spring DR. Diversity-oriented synthesis of macrocyclic peptidomimetics. Proceedings of the National Academy of Sciences of the United States of America. 108: 6793-8. PMID 21383137 DOI: 10.1073/Pnas.1015267108  0.653
2011 Xu Z, Singh NJ, Kim SK, Spring DR, Kim KS, Yoon J. Induction-driven stabilization of the anion-π interaction in electron-rich aromatics as the key to fluoride inclusion in imidazolium-cage receptors. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 1163-70. PMID 21243682 DOI: 10.1002/Chem.201002105  0.658
2010 Xu Z, Zheng S, Yoon J, Spring DR. Discovery of a highly selective turn-on fluorescent probe for Ag+. The Analyst. 135: 2554-9. PMID 20830329 DOI: 10.1039/C0An00405G  0.674
2010 Xu Z, Yoon J, Spring DR. A selective and ratiometric Cu2+ fluorescent probe based on naphthalimide excimer-monomer switching. Chemical Communications (Cambridge, England). 46: 2563-5. PMID 20461870 DOI: 10.1039/C000441C  0.658
2010 Xu Z, Yoon J, Spring DR. Fluorescent chemosensors for Zn(2+). Chemical Society Reviews. 39: 1996-2006. PMID 20428518 DOI: 10.1039/B916287A  0.658
2010 Xu Z, Han SJ, Lee C, Yoon J, Spring DR. Development of off-on fluorescent probes for heavy and transition metal ions. Chemical Communications (Cambridge, England). 46: 1679-81. PMID 20177614 DOI: 10.1039/B924503K  0.652
2010 Xu Z, Baek KH, Kim HN, Cui J, Qian X, Spring DR, Shin I, Yoon J. Zn2+-triggered amide tautomerization produces a highly Zn2+-selective, cell-permeable, and ratiometric fluorescent sensor. Journal of the American Chemical Society. 132: 601-10. PMID 20000765 DOI: 10.1021/ja907334j  0.714
2010 Xu Z, Pan J, Spring DR, Cui J, Yoon J. Ratiometric fluorescent and colorimetric sensors for Cu2+ based on 4,5-disubstituted-1,8-naphthalimide and sensing cyanide via Cu2+ displacement approach Tetrahedron. 66: 1678-1683. DOI: 10.1016/J.Tet.2010.01.008  0.411
2010 Xu Z, Yoon J, Spring DR. ChemInform Abstract: Fluorescent Chemosensors for Zn2+ Cheminform. 41. DOI: 10.1002/chin.201042278  0.424
2010 BALDWIN JE, SPRING DR, WHITEHEAD RC. ChemInform Abstract: A Novel Diels-Alder Approach to Hydroisoquinolines. Cheminform. 29: no-no. DOI: 10.1002/chin.199843163  0.312
2004 Huang J, Zhu H, Haggarty SJ, Spring DR, Hwang H, Jin F, Snyder M, Schreiber SL. Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proceedings of the National Academy of Sciences of the United States of America. 101: 16594-9. PMID 15539461 DOI: 10.1073/Pnas.0407117101  0.609
2002 Spring DR, Krishnan S, Blackwell HE, Schreiber SL. Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform. Journal of the American Chemical Society. 124: 1354-63. PMID 11841305 DOI: 10.1021/Ja017248O  0.703
2001 Clemons PA, Koehler AN, Wagner BK, Sprigings TG, Spring DR, King RW, Schreiber SL, Foley MA. A one-bead, one-stock solution approach to chemical genetics: part 2. Chemistry & Biology. 8: 1183-95. PMID 11755397 DOI: 10.1016/S1074-5521(01)00086-2  0.754
2000 Spring DR, Krishnan S, Schreiber SL. Towards Diversity-Oriented, Stereoselective Syntheses of Biaryl- or Bis(aryl)metal-Containing Medium Rings Journal of the American Chemical Society. 122: 5656-5657. DOI: 10.1021/Ja0010507  0.559
2000 Spring DR, Krishnan S, Schreiber SL. ChemInform Abstract: Towards Diversity-Oriented Stereoselective Syntheses of Biaryl- or Bis(aryl)metal-Containing Medium Rings. Cheminform. 31: no-no. DOI: 10.1002/chin.200040155  0.345
1998 Baldwin JE, Claridge TDW, Culshaw AJ, Heupel FA, Lee V, Spring DR, Whitehead RC, Boughtflower RJ, Mutton IM, Upton RJ. Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis. Angewandte Chemie (International Ed. in English). 37: 2661-2663. PMID 29711622 DOI: 10.1002/(Sici)1521-3773(19981016)37:19<2661::Aid-Anie2661>3.0.Co;2-D  0.308
1998 Baldwin JE, Spring DR, Whitehead RC. A novel Diels-Alder approach to hydroisoquinolines Tetrahedron Letters. 39: 5417-5420. DOI: 10.1016/S0040-4039(98)01043-0  0.33
1998 Baldwin JE, Spring DR, Atkinson CE, Lee V. Efficient synthesis of the sponge alkaloids cyclostellettamines A-F Tetrahedron. 54: 13655-13680. DOI: 10.1016/S0040-4020(98)00842-4  0.325
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