142 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lopes ME, Dos Santos LM, Sacks D, Vieira LQ, Carneiro MB. Resistance Against Infection Depends on Microbiota-Guided Macrophage Activation. Frontiers in Immunology. 12: 730437. PMID 34745100 DOI: 10.3389/fimmu.2021.730437  0.353
2020 Chaves MM, Lee SH, Kamenyeva O, Ghosh K, Peters NC, Sacks D. The role of dermis resident macrophages and their interaction with neutrophils in the early establishment of Leishmania major infection transmitted by sand fly bite. Plos Pathogens. 16: e1008674. PMID 33137149 DOI: 10.1371/journal.ppat.1008674  0.333
2020 Singh OP, Hasker E, Boelaert M, Sacks D, Sundar S. Xenodiagnosis to address key questions in visceral leishmaniasis control and elimination. Plos Neglected Tropical Diseases. 14: e0008363. PMID 32790716 DOI: 10.1371/Journal.Pntd.0008363  0.312
2020 Singh OP, Syn G, Nylén S, Engwerda C, Sacks D, Wilson ME, Kumar R, Chakravarty J, Sundar S, Blackwell JM, Fakiola M. Anti-Interleukin-10 Unleashes Transcriptional Response to Leishmanial Antigens in Visceral Leishmaniasis Patients. The Journal of Infectious Diseases. PMID 32614452 DOI: 10.1093/Infdis/Jiaa381  0.354
2020 Sacks DL. The Null Hypothesis of IFN-γ and Monocyte Function in Leishmaniasis. Cell Host & Microbe. 27: 683-684. PMID 32407702 DOI: 10.1016/J.Chom.2020.04.014  0.339
2020 Louradour I, Ferreira TR, Ghosh K, Shaik J, Sacks D. In Vitro Generation of Leishmania Hybrids. Cell Reports. 31: 107507. PMID 32294444 DOI: 10.1016/J.Celrep.2020.03.071  0.344
2020 Lewis MD, Paun A, Romano A, Langston H, Langner CA, Moore IN, Bock KW, Francisco AF, Brenchley JM, Sacks DL. Fatal progression of experimental visceral leishmaniasis is associated with intestinal parasitism and secondary infection by commensal bacteria, and is delayed by antibiotic prophylaxis. Plos Pathogens. 16: e1008456. PMID 32282850 DOI: 10.1371/Journal.Ppat.1008456  0.422
2020 Lee SH, Chaves MM, Kamenyeva O, Gazzinelli-Guimaraes PH, Kang B, Pessenda G, Passelli K, Tacchini-Cottier F, Kabat J, Jacobsen EA, Nutman TB, Sacks DL. M2-like, dermal macrophages are maintained via IL-4/CCL24-mediated cooperative interaction with eosinophils in cutaneous leishmaniasis. Science Immunology. 5. PMID 32276966 DOI: 10.1126/Sciimmunol.Aaz4415  0.389
2020 Kumar R, Bunn PT, Singh SS, Ng SS, Montes de Oca M, De Labastida Rivera F, Chauhan SB, Singh N, Faleiro RJ, Edwards CL, Frame TCM, Sheel M, Austin RJ, Lane SW, Bald T, ... ... Sacks D, et al. Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis. Cell Reports. 30: 2512-2525.e9. PMID 32101732 DOI: 10.1016/J.Celrep.2020.01.099  0.446
2019 Louradour I, Ghosh K, Inbar E, Sacks DL. CRISPR/Cas9 Mutagenesis in Phlebotomus papatasi: the Immune Deficiency Pathway Impacts Vector Competence for Leishmania major. Mbio. 10. PMID 31455654 DOI: 10.1128/Mbio.01941-19  0.422
2019 Zamboni DS, Sacks DL. Inflammasomes and Leishmania: in good times or bad, in sickness or in health. Current Opinion in Microbiology. 52: 70-76. PMID 31229882 DOI: 10.1016/J.Mib.2019.05.005  0.445
2019 Chakravarty J, Hasker E, Kansal S, Singh OP, Malaviya P, Singh AK, Chourasia A, Singh T, Sudarshan M, Singh AP, Singh B, Singh RP, Ostyn B, Fakiola M, Picado A, ... ... Sacks D, et al. Determinants for progression from asymptomatic infection to symptomatic visceral leishmaniasis: A cohort study. Plos Neglected Tropical Diseases. 13: e0007216. PMID 30917114 DOI: 10.1371/Journal.Pntd.0007216  0.373
2019 Chauhan SB, Faleiro R, Kumar R, Ng S, Singh B, Singh OP, Singh SS, Amante F, Rivera FL, Rai M, Chakravarty J, Sacks D, Nylen S, Sundar S, Engwerda C. IL-2 is an upstream regulator of CD4+ T cells from visceral leishmaniasis patients with therapeutic potential. The Journal of Infectious Diseases. PMID 30796820 DOI: 10.1093/Infdis/Jiz074  0.384
2017 Lee SH, Charmoy M, Romano A, Paun A, Chaves MM, Cope FO, Ralph DA, Sacks DL. Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment. The Journal of Experimental Medicine. PMID 29247046 DOI: 10.1084/Jem.20171389  0.433
2017 Carneiro MBH, Roma EH, Ranson AJ, Doria NA, Debrabant A, Sacks DL, Vieira LQ, Peters NC. NOX2-Derived Reactive Oxygen Species Control Inflammation during Leishmania amazonensis Infection by Mediating Infection-Induced Neutrophil Apoptosis. Journal of Immunology (Baltimore, Md. : 1950). PMID 29158417 DOI: 10.4049/Jimmunol.1700899  0.42
2017 Romano A, Carneiro MBH, Doria NA, Roma EH, Ribeiro-Gomes FL, Inbar E, Lee SH, Mendez J, Paun A, Sacks DL, Peters NC. Divergent roles for Ly6C+CCR2+CX3CR1+ inflammatory monocytes during primary or secondary infection of the skin with the intra-phagosomal pathogen Leishmania major. Plos Pathogens. 13: e1006479. PMID 28666021 DOI: 10.1371/Journal.Ppat.1006479  0.449
2017 Tiwary P, Singh SK, Kushwaha AK, Rowton E, Sacks D, Singh OP, Sundar S, Lawyer P. Establishing, Expanding, and Certifying a Closed Colony of Phlebotomus argentipes (Diptera: Psychodidae) for Xenodiagnostic Studies at the Kala Azar Medical Research Center, Muzaffarpur, Bihar, India. Journal of Medical Entomology. PMID 28525618 DOI: 10.1093/Jme/Tjx099  0.307
2017 Inbar E, Hughitt VK, Dillon LA, Ghosh K, El-Sayed NM, Sacks DL. The Transcriptome of Leishmania major Developmental Stages in Their Natural Sand Fly Vector. Mbio. 8. PMID 28377524 DOI: 10.1128/Mbio.00029-17  0.37
2017 Valverde JG, Paun A, Inbar E, Romano A, Lewis M, Ghosh K, Sacks D. Increased transmissibility of Leishmania donovani from the mammalian host to vector sand flies after multiple exposures to sand fly bites. The Journal of Infectious Diseases. PMID 28329329 DOI: 10.1093/Infdis/Jix115  0.354
2016 Singh N, Kumar R, Engwerda C, Sacks D, Nylen S, Sundar S. Tumor necrosis factor alpha neutralization has no direct effect on parasite burden, but causes impaired IFN-γ production by spleen cells from human visceral leishmaniasis patients. Cytokine. 85: 184-190. PMID 27372917 DOI: 10.1016/J.Cyto.2016.06.013  0.341
2016 Inbar E, Lawyer P, Sacks D, Podini D. The Potential Use of Forensic DNA Methods Applied to Sand Fly Blood Meal Analysis to Identify the Infection Reservoirs of Anthroponotic Visceral Leishmaniasis. Plos Neglected Tropical Diseases. 10: e0004706. PMID 27192489 DOI: 10.1371/Journal.Pntd.0004706  0.386
2016 Faleiro RJ, Kumar R, Bunn PT, Singh N, Chauhan SB, Sheel M, Amante FH, Montes de Oca M, Edwards CL, Ng SS, Best SE, Haque A, Beattie L, Hafner LM, Sacks D, et al. Combined Immune Therapy for the Treatment of Visceral Leishmaniasis. Plos Neglected Tropical Diseases. 10: e0004415. PMID 26872334 DOI: 10.1371/Journal.Pntd.0004415  0.46
2015 Charmoy M, Hurrell BP, Romano A, Lee SH, Ribeiro-Gomes F, Riteau N, Mayer-Barber K, Tacchini-Cottier F, Sacks DL. The Nlrp3 inflammasome, IL-1β, and neutrophil recruitment are required for susceptibility to a non-healing strain of Leishmania major in C57BL/6 mice. European Journal of Immunology. PMID 26689285 DOI: 10.1002/Eji.201546015  0.405
2015 Ribeiro-Gomes FL, Romano A, Lee S, Roffê E, Peters NC, Debrabant A, Sacks D. Apoptotic cell clearance of Leishmania major-infected neutrophils by dendritic cells inhibits CD8(+) T-cell priming in vitro by Mer tyrosine kinase-dependent signaling. Cell Death & Disease. 6: e2018. PMID 26658192 DOI: 10.1038/Cddis.2015.351  0.449
2015 Romano A, Doria NA, Mendez J, Sacks DL, Peters NC. Cutaneous Infection with Leishmania major Mediates Heterologous Protection against Visceral Infection with Leishmania infantum. Journal of Immunology (Baltimore, Md. : 1950). 195: 3816-27. PMID 26371247 DOI: 10.4049/Jimmunol.1500752  0.484
2015 Sacks D. Gateway to deLiver: How malaria sporozoites cross the sinusoidal barrier Journal of Experimental Medicine. 212: 1340-1340. PMID 26304979 DOI: 10.1084/Jem.2129Insight1  0.313
2015 Sacks DL, Melby PC. Animal models for the analysis of immune responses to leishmaniasis. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. 108: 19.2.1-19.2.24. PMID 25640990 DOI: 10.1002/0471142735.Im1902S108  0.429
2014 Peters NC, Pagán AJ, Lawyer PG, Hand TW, Henrique Roma E, Stamper LW, Romano A, Sacks DL. Chronic parasitic infection maintains high frequencies of short-lived Ly6C+CD4+ effector T cells that are required for protection against re-infection. Plos Pathogens. 10: e1004538. PMID 25473946 DOI: 10.1371/Journal.Ppat.1004538  0.391
2014 Sacks D. Lost but not forgotten Cell Host and Microbe. 16: 423-425. PMID 25299325 DOI: 10.1016/J.Chom.2014.09.017  0.369
2014 Kumar R, Singh N, Gautam S, Singh OP, Gidwani K, Rai M, Sacks D, Sundar S, Nylén S. Leishmania specific CD4 T cells release IFNγ that limits parasite replication in patients with visceral leishmaniasis. Plos Neglected Tropical Diseases. 8: e3198. PMID 25275531 DOI: 10.1371/Journal.Pntd.0003198  0.39
2014 Sacks DL. Vaccines against tropical parasitic diseases: a persisting answer to a persisting problem. Nature Immunology. 15: 403-5. PMID 24747701 DOI: 10.1038/Ni.2853  0.318
2014 Ribeiro-Gomes FL, Roma EH, Carneiro MB, Doria NA, Sacks DL, Peters NC. Site-dependent recruitment of inflammatory cells determines the effective dose of Leishmania major. Infection and Immunity. 82: 2713-27. PMID 24733090 DOI: 10.1128/Iai.01600-13  0.437
2014 Singh OP, Hasker E, Sacks D, Boelaert M, Sundar S. Asymptomatic Leishmania infection: a new challenge for Leishmania control. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 58: 1424-9. PMID 24585564 DOI: 10.1093/Cid/Ciu102  0.378
2014 Gautam S, Kumar R, Singh N, Singh AK, Rai M, Sacks D, Sundar S, Nylén S. CD8 T cell exhaustion in human visceral leishmaniasis. The Journal of Infectious Diseases. 209: 290-9. PMID 23922369 DOI: 10.1093/Infdis/Jit401  0.358
2013 Inbar E, Akopyants NS, Charmoy M, Romano A, Lawyer P, Elnaiem DE, Kauffmann F, Barhoumi M, Grigg M, Owens K, Fay M, Dobson DE, Shaik J, Beverley SM, Sacks D. The mating competence of geographically diverse Leishmania major strains in their natural and unnatural sand fly vectors. Plos Genetics. 9: e1003672. PMID 23935521 DOI: 10.1371/Journal.Pgen.1003672  0.301
2013 Pagán AJ, Peters NC, Debrabant A, Ribeiro-Gomes F, Pepper M, Karp CL, Jenkins MK, Sacks DL. Tracking antigen-specific CD4+ T cells throughout the course of chronic Leishmania major infection in resistant mice. European Journal of Immunology. 43: 427-38. PMID 23109292 DOI: 10.1002/Eji.201242715  0.466
2012 Peters NC, Bertholet S, Lawyer PG, Charmoy M, Romano A, Ribeiro-Gomes FL, Stamper LW, Sacks DL. Evaluation of recombinant Leishmania polyprotein plus glucopyranosyl lipid A stable emulsion vaccines against sand fly-transmitted Leishmania major in C57BL/6 mice. Journal of Immunology (Baltimore, Md. : 1950). 189: 4832-41. PMID 23045616 DOI: 10.4049/Jimmunol.1201676  0.445
2012 Ribeiro-Gomes FL, Sacks D. The influence of early neutrophil-Leishmania interactions on the host immune response to infection Frontiers in Cellular and Infection Microbiology. 2: 59. PMID 22919650 DOI: 10.3389/Fcimb.2012.00059  0.441
2012 Singh OP, Gidwani K, Kumar R, Nylén S, Jones SL, Boelaert M, Sacks D, Sundar S. Reassessment of immune correlates in human visceral leishmaniasis as defined by cytokine release in whole blood. Clinical and Vaccine Immunology : Cvi. 19: 961-6. PMID 22539471 DOI: 10.1128/Cvi.00143-12  0.429
2012 Ribeiro-Gomes FL, Peters NC, Debrabant A, Sacks DL. Efficient capture of infected neutrophils by dendritic cells in the skin inhibits the early anti-leishmania response. Plos Pathogens. 8: e1002536. PMID 22359507 DOI: 10.1371/Journal.Ppat.1002536  0.436
2012 Kumar R, Gautam S, Singh O, Singh N, Nylen S, Sacks D, Sundar S. P028 CD4+ T cells are source of antigen specific interferon-gamma production in whole blood of patients with visceral leishmaniasis Cytokine. 59: 527. DOI: 10.1016/J.Cyto.2012.06.111  0.355
2011 Giorgobiani E, Chitadze N, Chanturya G, Grdzelidze M, Jochim RC, Machablishvili A, Tushishvili T, Zedginidze Y, Manjgaladze MK, Iashvili N, Makharadze MP, Zakaraya T, Kikaleishvili K, Markhvashvili I, Badashvili G, ... ... Sacks D, et al. Epidemiologic aspects of an emerging focus of visceral leishmaniasis in Tbilisi, Georgia. Plos Neglected Tropical Diseases. 5: e1415. PMID 22180796 DOI: 10.1371/Journal.Pntd.0001415  0.325
2011 Stamper LW, Patrick RL, Fay MP, Lawyer PG, Elnaiem DE, Secundino N, Debrabant A, Sacks DL, Peters NC. Infection parameters in the sand fly vector that predict transmission of Leishmania major. Plos Neglected Tropical Diseases. 5: e1288. PMID 21886852 DOI: 10.1371/Journal.Pntd.0001288  0.387
2011 Gautam S, Kumar R, Maurya R, Nylén S, Ansari N, Rai M, Sundar S, Sacks D. IL-10 neutralization promotes parasite clearance in splenic aspirate cells from patients with visceral leishmaniasis. The Journal of Infectious Diseases. 204: 1134-7. PMID 21881130 DOI: 10.1093/Infdis/Jir461  0.389
2011 Ansari NA, Kumar R, Gautam S, Nylén S, Singh OP, Sundar S, Sacks D. IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis. Journal of Immunology (Baltimore, Md. : 1950). 186: 3977-85. PMID 21357266 DOI: 10.4049/Jimmunol.1003588  0.33
2010 Dobson DE, Kamhawi S, Lawyer P, Turco SJ, Beverley SM, Sacks DL. Leishmania major survival in selective Phlebotomus papatasi sand fly vector requires a specific SCG-encoded lipophosphoglycan galactosylation pattern. Plos Pathogens. 6: e1001185. PMID 21085609 DOI: 10.1371/Journal.Ppat.1001185  0.339
2010 Maurya R, Kumar R, Prajapati VK, Manandhar KD, Sacks D, Sundar S, Nylén S. Human visceral leishmaniasis is not associated with expansion or accumulation of Foxp3+ CD4 cells in blood or spleen Parasite Immunology. 32: 479-483. PMID 20591118 DOI: 10.1111/J.1365-3024.2010.01219.X  0.386
2010 Maurya R, Mehrotra S, Prajapati VK, Nylén S, Sacks D, Sundar S. Evaluation of blood agar microtiter plates for culturing Leishmania parasites to titrate parasite burden in spleen and peripheral blood of patients with visceral leishmaniasis Journal of Clinical Microbiology. 48: 1932-1934. PMID 20335419 DOI: 10.1128/Jcm.01733-09  0.304
2010 Yazdanbakhsh M, Sacks DL. Why does immunity to parasites take so long to develop? Nature Reviews. Immunology. 10: 80-1. PMID 20183893 DOI: 10.1038/Nri2673  0.401
2010 Secundino N, Kimblin N, Peters NC, Lawyer P, Capul AA, Beverley SM, Turco SJ, Sacks D. Proteophosphoglycan confers resistance of Leishmania major to midgut digestive enzymes induced by blood feeding in vector sand flies. Cellular Microbiology. 12: 906-18. PMID 20088949 DOI: 10.1111/J.1462-5822.2010.01439.X  0.365
2009 Sacks D. BAC talk about cell type-specific regulation of human IL-10 Proceedings of the National Academy of Sciences of the United States of America. 106: 16895-16896. PMID 19805024 DOI: 10.1073/Pnas.0909138106  0.398
2009 Anderson CF, Stumhofer JS, Hunter CA, Sacks D. IL-27 regulates IL-10 and IL-17 from CD4+ cells in nonhealing Leishmania major infection. Journal of Immunology (Baltimore, Md. : 1950). 183: 4619-27. PMID 19748991 DOI: 10.4049/Jimmunol.0804024  0.425
2009 Selvapandiyan A, Dey R, Nylen S, Duncan R, Sacks D, Nakhasi HL. Intracellular replication-deficient Leishmania donovani induces long lasting protective immunity against visceral leishmaniasis Journal of Immunology. 183: 1813-1820. PMID 19592661 DOI: 10.4049/Jimmunol.0900276  0.464
2009 Peters NC, Sacks DL. The impact of vector-mediated neutrophil recruitment on cutaneous leishmaniasis. Cellular Microbiology. 11: 1290-6. PMID 19545276 DOI: 10.1111/J.1462-5822.2009.01348.X  0.422
2009 Peters NC, Kimblin N, Secundino N, Kamhawi S, Lawyer P, Sacks DL. Vector transmission of leishmania abrogates vaccine-induced protective immunity. Plos Pathogens. 5: e1000484. PMID 19543375 DOI: 10.1371/Journal.Ppat.1000484  0.437
2008 Peters NC, Egen JG, Secundino N, Debrabant A, Kimblin N, Kamhawi S, Lawyer P, Fay MP, Germain RN, Sacks D. In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies. Science (New York, N.Y.). 321: 970-4. PMID 18703742 DOI: 10.1126/Science.1159194  0.328
2008 Kimblin N, Peters N, Debrabant A, Secundino N, Egen J, Lawyer P, Fay MP, Kamhawi S, Sacks D. Quantification of the infectious dose of Leishmania major transmitted to the skin by single sand flies. Proceedings of the National Academy of Sciences of the United States of America. 105: 10125-30. PMID 18626016 DOI: 10.1073/Pnas.0802331105  0.422
2008 Anderson CF, Lira R, Kamhawi S, Belkaid Y, Wynn TA, Sacks D. IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 mice. Journal of Immunology (Baltimore, Md. : 1950). 180: 4090-7. PMID 18322219 DOI: 10.4049/Jimmunol.180.6.4090  0.473
2007 Nylén S, Sacks D. Interleukin-10 and the pathogenesis of human visceral leishmaniasis Trends in Immunology. 28: 378-384. PMID 17689290 DOI: 10.1016/J.It.2007.07.004  0.428
2007 Nylén S, Maurya R, Eidsmo L, Das Manandhar K, Sundar S, Sacks D. Splenic accumulation of IL-10 mRNA in T cells distinct from CD4 +CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis Journal of Experimental Medicine. 204: 805-817. PMID 17389235 DOI: 10.1084/Jem.20061141  0.4
2007 Donovan MJ, Messmore AS, Scrafford DA, Sacks DL, Kamhawi S, McDowell MA. Uninfected mosquito bites confer protection against infection with malaria parasites. Infection and Immunity. 75: 2523-30. PMID 17339356 DOI: 10.1128/Iai.01928-06  0.665
2007 Anderson CF, Oukka M, Kuchroo VJ, Sacks D. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. The Journal of Experimental Medicine. 204: 285-97. PMID 17283207 DOI: 10.1084/Jem.20061886  0.417
2006 Huynh C, Sacks DL, Andrews NW. A Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes. The Journal of Experimental Medicine. 203: 2363-75. PMID 17000865 DOI: 10.1084/Jem.20060559  0.354
2006 Peters N, Sacks D. Immune privilege in sites of chronic infection: Leishmania and regulatory T cells. Immunological Reviews. 213: 159-79. PMID 16972903 DOI: 10.1111/J.1600-065X.2006.00432.X  0.475
2006 Bertholet S, Goldszmid R, Morrot A, Debrabant A, Afrin F, Collazo-Custodio C, Houde M, Desjardins M, Sher A, Sacks D. Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivo Journal of Immunology. 177: 3525-3533. PMID 16951311 DOI: 10.4049/Jimmunol.177.6.3525  0.362
2005 Bertholet S, Debrabant A, Afrin F, Caler E, Mendez S, Tabbara KS, Belkaid Y, Sacks DL. Antigen requirements for efficient priming of CD8+ T cells by Leishmania major-infected dendritic cells. Infection and Immunity. 73: 6620-8. PMID 16177338 DOI: 10.1128/Iai.73.10.6620-6628.2005  0.453
2005 Iborra S, Carrión J, Anderson C, Alonso C, Sacks D, Soto M. Vaccination with the Leishmania infantum acidic ribosomal P0 protein plus CpG oligodeoxynucleotides induces protection against cutaneous leishmaniasis in C57BL/6 mice but does not prevent progressive disease in BALB/c mice Infection and Immunity. 73: 5842-5852. PMID 16113303 DOI: 10.1128/Iai.73.9.5842-5852.2005  0.381
2005 Flynn B, Wang V, Sacks DL, Seder RA, Verthelyi D. Prevention and treatment of cutaneous leishmaniasis in primates by using synthetic type D/A oligodeoxynucleotides expressing CpG motifs. Infection and Immunity. 73: 4948-54. PMID 16041009 DOI: 10.1128/Iai.73.8.4948-4954.2005  0.373
2005 Tabbara KS, Peters NC, Afrin F, Mendez S, Bertholet S, Belkaid Y, Sacks DL. Conditions influencing the efficacy of vaccination with live organisms against Leishmania major infection. Infection and Immunity. 73: 4714-22. PMID 16040984 DOI: 10.1128/Iai.73.8.4714-4722.2005  0.442
2005 Anderson CF, Mendez S, Sacks DL. Nonhealing infection despite Th1 polarization produced by a strain of Leishmania major in C57BL/6 mice. Journal of Immunology (Baltimore, Md. : 1950). 174: 2934-41. PMID 15728505 DOI: 10.4049/Jimmunol.174.5.2934  0.447
2004 Kamhawi S, Ramalho-Ortigao M, Pham VM, Kumar S, Lawyer PG, Turco SJ, Barillas-Mury C, Sacks DL, Valenzuela JG. A role for insect galectins in parasite survival. Cell. 119: 329-41. PMID 15543683 DOI: 10.1016/J.Cell.2004.10.009  0.386
2004 Seder RA, Sacks DL. Memory may not need reminding. Nature Medicine. 10: 1045-7. PMID 15459703 DOI: 10.1038/Nm1004-1045  0.381
2004 Sacks D, Anderson C. Re-examination of the immunosuppressive mechanisms mediating non-cure of Leishmania infection in mice Immunological Reviews. 201: 225-238. PMID 15361244 DOI: 10.1111/J.0105-2896.2004.00185.X  0.435
2004 Mendez S, Reckling SK, Piccirillo CA, Sacks D, Belkaid Y. Role for CD4+ CD25+ regulatory T cells in reactivation of persistent Leishmaniasis and control of concomitant immunity Journal of Experimental Medicine. 200: 201-210. PMID 15263027 DOI: 10.1084/Jem.20040298  0.442
2003 Houde M, Bertholet S, Gagnon E, Brunet S, Goyette G, Laplante A, Princiotta MF, Thibault P, Sacks D, Desjardins M. Phagosomes are competent organelles for antigen cross-presentation. Nature. 425: 402-6. PMID 14508490 DOI: 10.1038/Nature01912  0.324
2003 Späth GF, Lye LF, Segawa H, Sacks DL, Turco SJ, Beverley SM. Persistence without pathology in phosphoglycan-deficient Leishmania major. Science (New York, N.Y.). 301: 1241-3. PMID 12947201 DOI: 10.1126/Science.1087499  0.302
2003 Mendez S, Tabbara K, Belkaid Y, Bertholet S, Verthelyi D, Klinman D, Seder RA, Sacks DL. Coinjection with CpG-containing immunostimulatory oligodeoxynucleotides reduces the pathogenicity of a live vaccine against cutaneous Leishmaniasis but maintains its potency and durability. Infection and Immunity. 71: 5121-9. PMID 12933855 DOI: 10.1128/Iai.71.9.5121-5129.2003  0.406
2003 Freidag BL, Mendez S, Cheever AW, Kenney RT, Flynn B, Sacks DL, Seder RA. Immunological and pathological evaluation of rhesus macaques infected with Leishmania major. Experimental Parasitology. 103: 160-8. PMID 12880593 DOI: 10.1016/S0014-4894(03)00099-7  0.41
2003 Zhang WW, Mendez S, Ghosh A, Myler P, Ivens A, Clos J, Sacks DL, Matlashewski G. Comparison of the A2 gene locus in Leishmania donovani and Leishmania major and its control over cutaneous infection. The Journal of Biological Chemistry. 278: 35508-15. PMID 12829719 DOI: 10.1074/Jbc.M305030200  0.334
2003 Noben-Trauth N, Lira R, Nagase H, Paul WE, Sacks DL. The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major. Journal of Immunology (Baltimore, Md. : 1950). 170: 5152-8. PMID 12734362 DOI: 10.4049/Jimmunol.170.10.5152  0.351
2003 Chaussabel D, Semnani RT, McDowell MA, Sacks D, Sher A, Nutman TB. Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites. Blood. 102: 672-81. PMID 12663451 DOI: 10.1182/Blood-2002-10-3232  0.616
2002 Belkaid Y, Piccirillo CA, Mendez S, Shevach EM, Sacks DL. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature. 420: 502-7. PMID 12466842 DOI: 10.1038/Nature01152  0.431
2002 Sacks D, Noben-Trauth N. The immunology of susceptibility and resistance to Leishmania major in mice Nature Reviews Immunology. 2: 845-858. PMID 12415308 DOI: 10.1038/Nri933  0.434
2002 Sacks D, Sher A. Evasion of innate immunity by parasitic protozoa Nature Immunology. 3: 1041-1047. PMID 12407413 DOI: 10.1038/Ni1102-1041  0.415
2002 Méndez S, Belkaid Y, Seder RA, Sacks D. Optimization of DNA vaccination against cutaneous leishmaniasis Vaccine. 20: 3702-3708. PMID 12399198 DOI: 10.1016/S0264-410X(02)00376-6  0.329
2002 von Stebut E, Belkaid Y, Nguyen B, Wilson M, Sacks DL, Udey MC. Skin-derived macrophages from Leishmania major-susceptible mice exhibit interleukin-12- and interferon-gamma-independent nitric oxide production and parasite killing after treatment with immunostimulatory DNA. The Journal of Investigative Dermatology. 119: 621-8. PMID 12230504 DOI: 10.1046/J.1523-1747.2002.01850.X  0.412
2002 McDowell MA, Marovich M, Lira R, Braun M, Sacks D. Leishmania priming of human dendritic cells for CD40 ligand-induced interleukin-12p70 secretion is strain and species dependent. Infection and Immunity. 70: 3994-4001. PMID 12117904 DOI: 10.1128/Iai.70.8.3994-4001.2002  0.633
2002 Rhee EG, Mendez S, Shah JA, Wu CY, Kirman JR, Turon TN, Davey DF, Davis H, Klinman DM, Coler RN, Sacks DL, Seder RA. Vaccination with heat-killed leishmania antigen or recombinant leishmanial protein and CpG oligodeoxynucleotides induces long-term memory CD4+ and CD8+ T cell responses and protection against leishmania major infection. The Journal of Experimental Medicine. 195: 1565-73. PMID 12070284 DOI: 10.1084/Jem.20020147  0.401
2002 Belkaid Y, Von Stebut E, Mendez S, Lira R, Caler E, Bertholet S, Udey MC, Sacks D. CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intradermal challenge with Leishmania major Journal of Immunology. 168: 3992-4000. PMID 11937556 DOI: 10.4049/Jimmunol.168.8.3992  0.411
2002 Joshi PB, Kelly BL, Kamhawi S, Sacks DL, McMaster WR. Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor. Molecular and Biochemical Parasitology. 120: 33-40. PMID 11849703 DOI: 10.1016/S0166-6851(01)00432-7  0.328
2001 Sacks DL, Melby PC. Animal models for the analysis of immune responses to leishmaniasis. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit 19.2. PMID 18432753 DOI: 10.1002/0471142735.Im1902S28  0.429
2001 Udey MC, von Stebut E, Mendez S, Sacks DL, Belkaid Y. Skin dendritic cells in murine cutaneous leishmaniasis. Immunobiology. 204: 590-4. PMID 11846222 DOI: 10.1078/0171-2985-00096  0.452
2001 Belkaid Y, Hoffmann KF, Mendez S, Kamhawi S, Udey MC, Wynn TA, Sacks DL. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. The Journal of Experimental Medicine. 194: 1497-506. PMID 11714756 DOI: 10.1084/Jem.194.10.1497  0.424
2001 Sacks D, Kamhawi S. Molecular aspects of parasite-vector and vector-host interactions in Leishmaniasis Annual Review of Microbiology. 55: 453-483. PMID 11544364 DOI: 10.1146/Annurev.Micro.55.1.453  0.424
2001 Valenzuela JG, Belkaid Y, Garfield MK, Mendez S, Kamhawi S, Rowton ED, Sacks DL, Ribeiro JM. Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein. The Journal of Experimental Medicine. 194: 331-42. PMID 11489952 DOI: 10.1084/Jem.194.3.331  0.398
2001 Sacks DL. Leishmania-sand fly interactions controlling species-specific vector competence. Cellular Microbiology. 3: 189-96. PMID 11298643 DOI: 10.1046/J.1462-5822.2001.00115.X  0.374
2001 Méndez S, Gurunathan S, Kamhawi S, Belkaid Y, Moga MA, Skeiky YAW, Campos-Neto A, Reed S, Seder RA, Sacks D. The potency and durability of DNA- and protein-based vaccines against Leishmania major evaluated using low-dose, intradermal challenge Journal of Immunology. 166: 5122-5128. PMID 11290794 DOI: 10.4049/Jimmunol.166.8.5122  0.386
2000 von Stebut E, Belkaid Y, Nguyen BV, Cushing M, Sacks DL, Udey MC. Leishmania major-infected murine langerhans cell-like dendritic cells from susceptible mice release IL-12 after infection and vaccinate against experimental cutaneous Leishmaniasis. European Journal of Immunology. 30: 3498-506. PMID 11093169 DOI: 10.1002/1521-4141(2000012)30:12<3498::Aid-Immu3498>3.0.Co;2-6  0.461
2000 Kamhawi S, Modi GB, Pimenta PF, Rowton E, Sacks DL. The vectorial competence of Phlebotomus sergenti is specific for Leishmania tropica and is controlled by species-specific, lipophosphoglycan-mediated midgut attachment. Parasitology. 121: 25-33. PMID 11085222 DOI: 10.1017/S0031182099006125  0.344
2000 Kamhawi S, Belkaid Y, Modi G, Rowton E, Sacks D. Protection against cutaneous leishmaniasis resulting from bites of uninfected sand flies Science. 290: 1351-1354. PMID 11082061 DOI: 10.1126/Science.290.5495.1351  0.437
2000 Lira R, Doherty M, Modi G, Sacks D. Evolution of lesion formation, parasitic load, immune response, and reservoir potential in C57BL/6 mice following high- and low-dose challenge with leishmania major Infection and Immunity. 68: 5176-5182. PMID 10948141 DOI: 10.1128/Iai.68.9.5176-5182.2000  0.442
2000 Stobie L, Gurunathan S, Prussin C, Sacks DL, Glaichenhaus N, Wu CY, Seder RA. The role of antigen and IL-12 in sustaining Th1 memory cells in vivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge. Proceedings of the National Academy of Sciences of the United States of America. 97: 8427-32. PMID 10890924 DOI: 10.1073/Pnas.160197797  0.41
2000 Belkaid Y, Mendez S, Lira R, Kadambi N, Milon G, Sacks D. A natural model of Leishmania major infection reveals a prolonged 'silent' phase of parasite amplification in the skin before the onset of lesion formation and immunity Journal of Immunology. 165: 969-977. PMID 10878373 DOI: 10.4049/Jimmunol.165.2.969  0.459
2000 Gurunathan S, Stobie L, Prussin C, Sacks DL, Glaichenhaus N, Iwasaki A, Fowell DJ, Locksley RM, Chang JT, Wu CY, Seder RA. Requirements for the maintenance of Th1 immunity in vivo following DNA vaccination: a potential immunoregulatory role for CD8+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 165: 915-24. PMID 10878366 DOI: 10.4049/Jimmunol.165.2.915  0.38
2000 Belkaid Y, Valenzuela JG, Kamhawi S, Rowton E, Sacks DL, Ribeiro JM. Delayed-type hypersensitivity to Phlebotomus papatasi sand fly bite: An adaptive response induced by the fly? Proceedings of the National Academy of Sciences of the United States of America. 97: 6704-9. PMID 10841567 DOI: 10.1073/Pnas.97.12.6704  0.334
2000 Sacks DL, Modi G, Rowton E, Späth G, Epstein L, Turco SJ, Beverley SM. The role of phosphoglycans in Leishmania-sand fly interactions. Proceedings of the National Academy of Sciences of the United States of America. 97: 406-11. PMID 10618431 DOI: 10.1073/Pnas.97.1.406  0.349
1999 McDowell MA, Sacks DL. Inhibition of host cell signal transduction by Leishmania: observations relevant to the selective impairment of IL-12 responses. Current Opinion in Microbiology. 2: 438-43. PMID 10458990 DOI: 10.1016/S1369-5274(99)80077-0  0.653
1999 Mahoney AB, Sacks DL, Saraiva E, Modi G, Turco SJ. Intra-species and stage-specific polymorphisms in lipophosphoglycan structure control Leishmania donovani-sand fly interactions. Biochemistry. 38: 9813-23. PMID 10433687 DOI: 10.1021/Bi990741G  0.354
1999 Courret N, Prina E, Mougneau E, Saraiva EM, Sacks DL, Glaichenhaus N, Antoine JC. Presentation of the Leishmania antigen LACK by infected macrophages is dependent upon the virulence of the phagocytosed parasites. European Journal of Immunology. 29: 762-73. PMID 10092078 DOI: 10.1002/(Sici)1521-4141(199903)29:03<762::Aid-Immu762>3.0.Co;2-4  0.463
1998 Gurunathan S, Prussin C, Sacks DL, Seder RA. Vaccine requirements for sustained cellular immunity to an intracellular parasitic infection. Nature Medicine. 4: 1409-15. PMID 9846579 DOI: 10.1038/4000  0.447
1998 Belkaid Y, Kamhawi S, Modi G, Valenzuela J, Noben-Trauth N, Rowton E, Ribeiro J, Sacks DL. Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva preexposure on the long-term outcome of Leishmania major infection in the mouse ear dermis. The Journal of Experimental Medicine. 188: 1941-53. PMID 9815271 DOI: 10.1084/Jem.188.10.1941  0.414
1998 von Stebut E, Belkaid Y, Jakob T, Sacks DL, Udey MC. Uptake of Leishmania major amastigotes results in activation and interleukin 12 release from murine skin-derived dendritic cells: implications for the initiation of anti-Leishmania immunity. The Journal of Experimental Medicine. 188: 1547-52. PMID 9782133 DOI: 10.1084/Jem.188.8.1547  0.457
1998 Lira R, Méndez S, Carrera L, Jaffe C, Neva F, Sacks D. Leishmania tropica:The Identification and Purification of Metacyclic Promastigotes and Use in Establishing Mouse and Hamster Models of Cutaneous and Visceral Disease Experimental Parasitology. 89: 331-342. PMID 9676711 DOI: 10.1006/Expr.1998.4283  0.422
1998 Belkaid Y, Butcher B, Sacks DL. Analysis of cytokine production by inflammatory mouse macrophages at the single-cell level: selective impairment of IL-12 induction in Leishmania-infected cells. European Journal of Immunology. 28: 1389-400. PMID 9565379 DOI: 10.1002/(Sici)1521-4141(199804)28:04<1389::Aid-Immu1389>3.0.Co;2-1  0.438
1998 Kenney RT, Sacks DL, Gam AA, Murray HW, Sundar S. Splenic cytokine responses in Indian kala-azar before and after treatment. The Journal of Infectious Diseases. 177: 815-8. PMID 9498473 DOI: 10.1086/517817  0.336
1998 Joshi PB, Sacks DL, Modi G, McMaster WR. Targeted gene deletion of Leishmania major genes encoding developmental stage-specific leishmanolysin (GP63). Molecular Microbiology. 27: 519-30. PMID 9489664 DOI: 10.1046/J.1365-2958.1998.00689.X  0.303
1997 Pimenta PF, Modi GB, Pereira ST, Shahabuddin M, Sacks DL. A novel role for the peritrophic matrix in protecting Leishmania from the hydrolytic activities of the sand fly midgut. Parasitology. 115: 359-69. PMID 9364562 DOI: 10.1017/S0031182097001510  0.399
1997 Gurunathan S, Sacks DL, Brown DR, Reiner SL, Charest H, Glaichenhaus N, Seder RA. Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. The Journal of Experimental Medicine. 186: 1137-47. PMID 9314562 DOI: 10.1084/Jem.186.7.1137  0.375
1996 Butcher BA, Turco SJ, Hilty BA, Pimenta PF, Panunzio M, Sacks DL. Deficiency in beta1,3-galactosyltransferase of a Leishmania major lipophosphoglycan mutant adversely influences the Leishmania-sand fly interaction. The Journal of Biological Chemistry. 271: 20573-9. PMID 8702802 DOI: 10.1074/Jbc.271.34.20573  0.346
1996 Carrera L, Gazzinelli RT, Badolato R, Hieny S, Muller W, Kuhn R, Sacks DL. Leishmania promastigotes selectively inhibit interleukin 12 induction in bone marrow-derived macrophages from susceptible and resistant mice. The Journal of Experimental Medicine. 183: 515-26. PMID 8627163 DOI: 10.1084/Jem.183.2.515  0.401
1996 Badolato R, Sacks DL, Savoia D, Musso T. Leishmania major: infection of human monocytes induces expression of IL-8 and MCAF. Experimental Parasitology. 82: 21-6. PMID 8617327 DOI: 10.1006/Expr.1996.0003  0.427
1995 Sacks DL, Pimenta PF, McConville MJ, Schneider P, Turco SJ. Stage-specific binding of Leishmania donovani to the sand fly vector midgut is regulated by conformational changes in the abundant surface lipophosphoglycan. The Journal of Experimental Medicine. 181: 685-97. PMID 7836922 DOI: 10.1084/Jem.181.2.685  0.352
1995 Sacks DL, Kenney RT, Kreutzer RD, Jaffe CL, Gupta AK, Sharma MC, Sinha SP, Neva FA, Saran R. Indian kala-azar caused by Leishmania tropica. Lancet. 345: 959-61. PMID 7715298 DOI: 10.1016/S0140-6736(95)90703-3  0.339
1995 Saraiva EM, Pimenta PF, Brodin TN, Rowton E, Modi GB, Sacks DL. Changes in lipophosphoglycan and gene expression associated with the development of Leishmania major in Phlebotomus papatasi. Parasitology. 111: 275-87. PMID 7567096 DOI: 10.1017/S003118200008183X  0.322
1994 Carrera L, Chiaramonte M, Kuhn R, Muller W, Sacks D, Sher A, Gazzinelli RT. Leishmania major and Toxoplasma gondii have opposite effects on cytokine synthesis by macrophages. MemóRias Do Instituto Oswaldo Cruz. 89: 649-50. PMID 8524067 DOI: 10.1590/S0074-02761994000400024  0.322
1994 Pimenta PF, Saraiva EM, Rowton E, Modi GB, Garraway LA, Beverley SM, Turco SJ, Sacks DL. Evidence that the vectorial competence of phlebotomine sand flies for different species of Leishmania is controlled by structural polymorphisms in the surface lipophosphoglycan. Proceedings of the National Academy of Sciences of the United States of America. 91: 9155-9. PMID 8090785 DOI: 10.1073/Pnas.91.19.9155  0.335
1994 Sacks DL, Saraiva EM, Rowton E, Turco SJ, Pimenta PF. The role of the lipophosphoglycan of Leishmania in vector competence. Parasitology. 108: S55-62. PMID 8084656 DOI: 10.1017/S0031182000075727  0.358
1993 Karp CL, el-Safi SH, Wynn TA, Satti MM, Kordofani AM, Hashim FA, Hag-Ali M, Neva FA, Nutman TB, Sacks DL. In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. The Journal of Clinical Investigation. 91: 1644-8. PMID 8097208 DOI: 10.1172/Jci116372  0.401
1992 Pimenta PF, Turco SJ, McConville MJ, Lawyer PG, Perkins PV, Sacks DL. Stage-specific adhesion of Leishmania promastigotes to the sandfly midgut. Science (New York, N.Y.). 256: 1812-5. PMID 1615326 DOI: 10.1126/Science.1615326  0.386
1989 Sacks DL. Metacyclogenesis in Leishmania promastigotes. Experimental Parasitology. 69: 100-3. PMID 2659372 DOI: 10.1016/0014-4894(89)90176-8  0.362
1989 Melby PC, Sacks DL. Identification of antigens recognized by T cells in human leishmaniasis: analysis of T-cell clones by immunoblotting. Infection and Immunity. 57: 2971-6. PMID 2476395 DOI: 10.1128/Iai.57.10.2971-2976.1989  0.373
1989 Melby PC, Neva FA, Sacks DL. Profile of human T cell response to leishmanial antigens. Analysis by immunoblotting. The Journal of Clinical Investigation. 83: 1868-75. PMID 2470787 DOI: 10.1172/Jci114093  0.389
1988 Puentes SM, Sacks DL, da Silva RP, Joiner KA. Complement binding by two developmental stages of Leishmania major promastigotes varying in expression of a surface lipophosphoglycan. The Journal of Experimental Medicine. 167: 887-902. PMID 3280727 DOI: 10.1084/Jem.167.3.887  0.361
1988 Sacks DL. B cell dependent T lymphocyte responses in leishmaniasis. Memã³Rias Do Instituto Oswaldo Cruz. 83: 506-13. PMID 3267033 DOI: 10.1590/S0074-02761988000500060  0.388
1987 da Silva R, Sacks DL. Metacyclogenesis is a major determinant of Leishmania promastigote virulence and attenuation. Infection and Immunity. 55: 2802-6. PMID 3666964 DOI: 10.1128/Iai.55.11.2802-2806.1987  0.335
1987 Sacks DL, Lal SL, Shrivastava SN, Blackwell J, Neva FA. An analysis of T cell responsiveness in Indian kala-azar. Journal of Immunology (Baltimore, Md. : 1950). 138: 908-13. PMID 3100620  0.319
1985 Sacks DL, Perkins PV. Development of infective stage Leishmania promastigotes within phlebotomine sand flies. The American Journal of Tropical Medicine and Hygiene. 34: 456-9. PMID 4039899 DOI: 10.4269/Ajtmh.1985.34.456  0.39
1983 Barral A, Petersen EA, Sacks DL, Neva FA. Late metastatic Leishmaniasis in the mouse. A model for mucocutaneous disease. The American Journal of Tropical Medicine and Hygiene. 32: 277-85. PMID 6837839 DOI: 10.4269/Ajtmh.1983.32.277  0.405
1983 Sacks DL, Kelsoe GH, Sachs DH. Induction of immune responses with anti-idiotypic antibodies: implications for the induction of protective immunity. Springer Seminars in Immunopathology. 6: 79-97. PMID 6412379 DOI: 10.1007/Bf01857368  0.306
1983 Sher A, Sacks DL, Scott PA. Host and parasite factors influencing the expression of cutaneous leishmaniasis. Ciba Foundation Symposium. 99: 174-89. PMID 6227463  0.316
1982 Sacks DL, Esser KM, Sher A. Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies. The Journal of Experimental Medicine. 155: 1108-19. PMID 6977615 DOI: 10.1084/Jem.155.4.1108  0.373
1980 Sacks DL, Selkirk M, Ogilvie BM, Askonas BA. Intrinsic immunosuppressive activity of different trypanosome strains varies with parasite virulence. Nature. 283: 476-8. PMID 7352025 DOI: 10.1038/283476A0  0.314
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