Kevin M. Weeks - Publications

Affiliations: 
Chemistry University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Structural and Chemical Biology of the Transcriptome
Website:
http://www.chem.unc.edu/people/faculty/weeks/index.html

168 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Chen LL, Ingolia NT, Insco ML, Li JB, Oberdoerffer S, Weeks KM. Voices: Challenges and opportunities in RNA biology. Cell Chemical Biology. 31: 10-13. PMID 38242091 DOI: 10.1016/j.chembiol.2023.12.015  0.626
2023 Xiang Y, Huang W, Tan L, Chen T, He Y, Irving PS, Weeks KM, Zhang QC, Dong X. Pervasive downstream RNA hairpins dynamically dictate start-codon selection. Nature. PMID 37674078 DOI: 10.1038/s41586-023-06500-y  0.521
2023 Mustoe AM, Weidmann CA, Weeks KM. Correction to "Single-Molecule Correlated Chemical Probing: A Revolution in RNA Structure Analysis". Accounts of Chemical Research. 56: 1684. PMID 37283502 DOI: 10.1021/acs.accounts.3c00304  0.552
2023 Irving PS, Weeks KM. RNAvigate: Efficient exploration of RNA chemical probing datasets. Biorxiv : the Preprint Server For Biology. PMID 37162917 DOI: 10.1101/2023.04.25.538311  0.669
2023 Boerneke MA, Gokhale NS, Horner SM, Weeks KM. Structure-first identification of RNA elements that regulate dengue virus genome architecture and replication. Proceedings of the National Academy of Sciences of the United States of America. 120: e2217053120. PMID 37011200 DOI: 10.1073/pnas.2217053120  0.609
2023 Mustoe AM, Weidmann CA, Weeks KM. Single-Molecule Correlated Chemical Probing: A Revolution in RNA Structure Analysis. Accounts of Chemical Research. 56: 763-775. PMID 36917683 DOI: 10.1021/acs.accounts.2c00782  0.695
2023 Koehn JT, Felder S, Weeks KM. Innovations in targeting RNA by fragment-based ligand discovery. Current Opinion in Structural Biology. 79: 102550. PMID 36863268 DOI: 10.1016/j.sbi.2023.102550  0.894
2022 Grayeski PJ, Weidmann CA, Kumar J, Lackey L, Mustoe AM, Busan S, Laederach A, Weeks KM. Global 5'-UTR RNA structure regulates translation of a SERPINA1 mRNA. Nucleic Acids Research. 50: 9689-9704. PMID 36107773 DOI: 10.1093/nar/gkac739  0.498
2022 Roden CA, Dai Y, Giannetti CA, Seim I, Lee M, Sealfon R, McLaughlin GA, Boerneke MA, Iserman C, Wey SA, Ekena JL, Troyanskaya OG, Weeks KM, You L, Chilkoti A, et al. Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures. Nucleic Acids Research. PMID 35871289 DOI: 10.1093/nar/gkac596  0.588
2022 Arney JW, Weeks KM. RNA-Ligand Interactions Quantified by Surface Plasmon Resonance with Reference Subtraction. Biochemistry. PMID 35802500 DOI: 10.1021/acs.biochem.2c00177  0.574
2022 Kumar J, Lackey L, Waldern JM, Dey A, Mustoe AM, Weeks K, Mathews DH, Laederach A. Quantitative prediction of variant effects on alternative splicing in using endogenous pre-messenger RNA structure probing. Elife. 11. PMID 35695373 DOI: 10.7554/eLife.73888  0.457
2022 Zeller MJ, Favorov O, Li K, Nuthanakanti A, Hussein D, Michaud A, Lafontaine DA, Busan S, Serganov A, Aubé J, Weeks KM. SHAPE-enabled fragment-based ligand discovery for RNA. Proceedings of the National Academy of Sciences of the United States of America. 119: e2122660119. PMID 35561226 DOI: 10.1073/pnas.2122660119  0.581
2022 Olson SW, Turner AW, Arney JW, Saleem I, Weidmann CA, Margolis DM, Weeks KM, Mustoe AM. Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP. Molecular Cell. PMID 35320755 DOI: 10.1016/j.molcel.2022.02.009  0.65
2022 Stephenson W, Razaghi R, Busan S, Weeks KM, Timp W, Smibert P. Direct detection of RNA modifications and structure using single-molecule nanopore sequencing. Cell Genomics. 2. PMID 35252946 DOI: 10.1016/j.xgen.2022.100097  0.658
2022 Przanowska RK, Weidmann CA, Saha S, Cichewicz MA, Jensen KN, Przanowski P, Irving PS, Janes KA, Guertin MJ, Weeks KM, Dutta A. Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors. Cell Reports. 38: 110361. PMID 35172143 DOI: 10.1016/j.celrep.2022.110361  0.482
2022 Zeller MJ, Nuthanakanti A, Li K, Aubé J, Serganov A, Weeks KM. Subsite Ligand Recognition and Cooperativity in the TPP Riboswitch: Implications for Fragment-Linking in RNA Ligand Discovery. Acs Chemical Biology. 17: 438-448. PMID 35060698 DOI: 10.1021/acschembio.1c00880  0.558
2021 Christy TW, Giannetti CA, Laederach A, Weeks KM. Identifying proximal RNA interactions from cDNA-encoded crosslinks with ShapeJumper. Plos Computational Biology. 17: e1009632. PMID 34905538 DOI: 10.1371/journal.pcbi.1009632  0.566
2021 Weeks KM. Piercing the fog of the RNA structure-ome. Science (New York, N.Y.). 373: 964-965. PMID 34446594 DOI: 10.1126/science.abk1971  0.698
2021 Roden CA, Dai Y, Seim I, Lee M, Sealfon R, McLaughlin GA, Boerneke MA, Iserman C, Wey SA, Ekena JL, Troyanskaya OG, Weeks KM, You L, Chilkoti A, Gladfelter AS. Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures. Biorxiv : the Preprint Server For Biology. PMID 34159327 DOI: 10.1101/2021.06.14.448452  0.514
2021 Christy TW, Giannetti CA, Houlihan G, Smola MJ, Rice GM, Wang J, Dokholyan NV, Laederach A, Holliger P, Weeks KM. Direct Mapping of Higher-Order RNA Interactions by SHAPE-JuMP. Biochemistry. PMID 34121404 DOI: 10.1021/acs.biochem.1c00270  0.715
2021 Weeks KM. SHAPE Directed Discovery of New Functions in Large RNAs. Accounts of Chemical Research. 54: 2502-2517. PMID 33960770 DOI: 10.1021/acs.accounts.1c00118  0.725
2021 Busan S, Weeks KM. Visualization of lncRNA and mRNA Structure Models Within the Integrative Genomics Viewer. Methods in Molecular Biology (Clifton, N.J.). 2254: 15-25. PMID 33326067 DOI: 10.1007/978-1-0716-1158-6_2  0.639
2020 Iserman C, Roden CA, Boerneke MA, Sealfon RSG, McLaughlin GA, Jungreis I, Fritch EJ, Hou YJ, Ekena J, Weidmann CA, Theesfeld CL, Kellis M, Troyanskaya OG, Baric RS, Sheahan TP, ... Weeks KM, et al. Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid. Molecular Cell. PMID 33290746 DOI: 10.1016/j.molcel.2020.11.041  0.483
2020 Ehrhardt JE, Weeks KM. Time-Resolved, Single-Molecule, Correlated Chemical Probing of RNA. Journal of the American Chemical Society. PMID 33095984 DOI: 10.1021/jacs.0c06221  0.695
2020 Weidmann CA, Mustoe AM, Jariwala PB, Calabrese JM, Weeks KM. Analysis of RNA-protein networks with RNP-MaP defines functional hubs on RNA. Nature Biotechnology. PMID 33077962 DOI: 10.1038/s41587-020-0709-7  0.538
2020 Iserman C, Roden C, Boerneke M, Sealfon R, McLaughlin G, Jungreis I, Park C, Boppana A, Fritch E, Hou YJ, Theesfeld C, Troyanskaya OG, Baric RS, Sheahan TP, Weeks K, et al. Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate. Biorxiv : the Preprint Server For Biology. PMID 32587965 DOI: 10.1101/2020.06.11.147199  0.468
2020 Schmidt K, Weidmann CA, Hilimire TA, Yee E, Hatfield BM, Schneekloth JS, Weeks KM, Novina CD. Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor. Cell Reports. 30: 541-554.e5. PMID 31940495 DOI: 10.1016/J.Celrep.2019.12.011  0.567
2019 Mustoe AM, Lama NN, Irving PS, Olson SW, Weeks KM. RNA base-pairing complexity in living cells visualized by correlated chemical probing. Proceedings of the National Academy of Sciences of the United States of America. PMID 31744869 DOI: 10.1073/Pnas.1905491116  0.71
2019 Sengupta A, Rice GM, Weeks KM. Single-molecule correlated chemical probing reveals large-scale structural communication in the ribosome and the mechanism of the antibiotic spectinomycin in living cells. Plos Biology. 17: e3000393. PMID 31487286 DOI: 10.1371/Journal.Pbio.3000393  0.645
2019 Boerneke MA, Ehrhardt JE, Weeks KM. Physical and Functional Analysis of Viral RNA Genomes by SHAPE. Annual Review of Virology. PMID 31337286 DOI: 10.1146/Annurev-Virology-092917-043315  0.69
2019 Giannetti C, Busan S, Weidmann C, Weeks KM. SHAPE probing reveals human ribosomal RNAs are largely unfolded in solution. Biochemistry. PMID 31305988 DOI: 10.1021/Acs.Biochem.9B00076  0.638
2019 Dethoff EA, Weeks KM. Effects of Refolding on Large-Scale RNA Structure. Biochemistry. PMID 31268687 DOI: 10.1021/Acs.Biochem.8B01219  0.77
2019 Busan S, Weidmann C, Sengupta A, Weeks KM. Guidelines for SHAPE reagent choice and detection strategy for RNA structure probing studies. Biochemistry. PMID 31117385 DOI: 10.1021/Acs.Biochem.8B01218  0.654
2019 Tolbert M, Parish PC, Olson SW, Mitrea DM, Weeks K, Kriwacki RW. Molecular Insights into the Role of RNA Structure in the Phase Separated Nucleolus Biophysical Journal. 116: 348a. DOI: 10.1016/J.Bpj.2018.11.1898  0.631
2018 Boerneke MA, Weeks KM. High-Throughput Explorations of RNA Structural Modularity. Biochemistry. 57: 6129-6131. PMID 30373370 DOI: 10.1021/Acs.Biochem.8B00999  0.726
2018 Dethoff EA, Boerneke MA, Gokhale NS, Muhire BM, Martin DP, Sacco MT, McFadden MJ, Weinstein JB, Messer WB, Horner SM, Weeks KM. Pervasive tertiary structure in the dengue virus RNA genome. Proceedings of the National Academy of Sciences of the United States of America. PMID 30341219 DOI: 10.1073/Pnas.1716689115  0.737
2018 Kirk JM, Kim SO, Inoue K, Smola MJ, Lee DM, Schertzer MD, Wooten JS, Baker AR, Sprague D, Collins DW, Horning CR, Wang S, Chen Q, Weeks KM, Mucha PJ, et al. Functional classification of long non-coding RNAs by k-mer content. Nature Genetics. PMID 30224646 DOI: 10.1038/S41588-018-0207-8  0.452
2018 Warner KD, Hajdin CE, Weeks KM. Principles for targeting RNA with drug-like small molecules. Nature Reviews. Drug Discovery. PMID 29977051 DOI: 10.1038/Nrd.2018.93  0.883
2018 Mustoe AM, Corley M, Laederach A, Weeks KM. Messenger RNA Structure Regulates Translation Initiation: A Mechanism Exploited from Bacteria to Humans. Biochemistry. PMID 29894169 DOI: 10.1021/Acs.Biochem.8B00395  0.645
2018 Smola MJ, Weeks KM. In-cell RNA structure probing with SHAPE-MaP. Nature Protocols. 13: 1181-1195. PMID 29725122 DOI: 10.1038/Nprot.2018.010  0.69
2018 Langdon EM, Qiu Y, Ghanbari Niaki A, McLaughlin GA, Weidmann C, Gerbich TM, Smith JA, Crutchley JM, Termini CM, Weeks KM, Myong S, Gladfelter AS. mRNA structure determines specificity of a polyQ-driven phase separation. Science (New York, N.Y.). PMID 29650703 DOI: 10.1126/Science.Aar7432  0.712
2018 Mustoe AM, Busan S, Rice GM, Hajdin CE, Peterson BK, Ruda VM, Kubica N, Nutiu R, Baryza JL, Weeks KM. Pervasive Regulatory Functions of mRNA Structure Revealed by High-Resolution SHAPE Probing. Cell. PMID 29551268 DOI: 10.1016/J.Cell.2018.02.034  0.823
2017 Williams B, Zhao B, Tandon A, Ding F, Weeks KM, Zhang Q, Dokholyan NV. Structure modeling of RNA using sparse NMR constraints. Nucleic Acids Research. PMID 29165648 DOI: 10.1093/Nar/Gkx1058  0.743
2017 Liu Y, Chen J, Nikolaitchik OA, Desimmie BA, Busan S, Pathak VK, Weeks KM, Hu WS. The roles of five conserved lentiviral RNA structures in HIV-1 replication. Virology. 514: 1-8. PMID 29128752 DOI: 10.1016/J.Virol.2017.10.020  0.58
2017 Busan S, Weeks KM. Accurate detection of chemical modifications in RNA by mutational profiling (MaP) with ShapeMapper 2. Rna (New York, N.Y.). PMID 29114018 DOI: 10.1261/Rna.061945.117  0.506
2017 Corley M, Solem A, Phillips G, Lackey L, Ziehr B, Vincent HA, Mustoe AM, Ramos SBV, Weeks KM, Moorman NJ, Laederach A. An RNA structure-mediated, posttranscriptional model of human α-1-antitrypsin expression. Proceedings of the National Academy of Sciences of the United States of America. PMID 29109288 DOI: 10.1073/Pnas.1706539114  0.448
2017 Busan S, Weeks KM. Visualization of RNA structure models within the Integrative Genomics Viewer. Rna (New York, N.Y.). PMID 28428329 DOI: 10.1261/Rna.060194.116  0.682
2017 Larman BC, Dethoff EA, Weeks KM. Packaged and free STMV RNA genomes adopt distinct conformational states. Biochemistry. PMID 28332826 DOI: 10.1021/Acs.Biochem.6B01166  0.682
2017 Miao Z, Adamiak RW, Antczak M, Batey RT, Becka AJ, Biesiada M, Boniecki MJ, Bujnicki J, Chen SJ, Cheng CY, Chou FC, Ferré-D'Amaré AR, Das R, Dawson WK, Feng D, ... ... Weeks KM, et al. RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme. Rna (New York, N.Y.). PMID 28138060 DOI: 10.1261/Rna.060368.116  0.801
2016 Krokhotin A, Mustoe AM, Weeks KM, Dokholyan NV. DIRECT IDENTIFICATION OF BASE-PAIRED RNA NUCLEOTIDES BY CORRELATED CHEMICAL PROBING. Rna (New York, N.Y.). PMID 27803152 DOI: 10.1261/Rna.058586.116  0.682
2016 Smola MJ, Christy TW, Inoue K, Nicholson CO, Friedersdorf M, Keene JD, Lee DM, Calabrese JM, Weeks KM. SHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across the Xist lncRNA in living cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 27578869 DOI: 10.1073/Pnas.1600008113  0.701
2016 Weidmann CA, Mustoe AM, Weeks KM. Direct Duplex Detection: An Emerging Tool in the RNA Structure Analysis Toolbox. Trends in Biochemical Sciences. PMID 27427309 DOI: 10.1016/J.Tibs.2016.07.001  0.743
2016 Kariisa AT, Weeks K, Tamayo R. The RNA Domain Vc1 Regulates Downstream Gene Expression in Response to Cyclic Diguanylate in Vibrio cholerae. Plos One. 11: e0148478. PMID 26849223 DOI: 10.1371/Journal.Pone.0148478  0.371
2015 Smola MJ, Calabrese JM, Weeks KM. Detection of RNA-Protein Interactions in Living Cells with SHAPE. Biochemistry. PMID 26544910 DOI: 10.1021/Acs.Biochem.5B00977  0.701
2015 Lu YF, Mauger DM, Goldstein DB, Urban TJ, Weeks KM, Bradrick SS. IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance. Scientific Reports. 5: 16037. PMID 26531896 DOI: 10.1038/Srep16037  0.421
2015 Tyrrell J, Weeks KM, Pielak GJ. Challenge of Mimicking the Influences of the Cellular Environment on RNA Structure by PEG-Induced Macromolecular Crowding. Biochemistry. 54: 6447-53. PMID 26430778 DOI: 10.1021/Acs.Biochem.5B00767  0.7
2015 Smola MJ, Rice GM, Busan S, Siegfried NA, Weeks KM. Selective 2'-hydroxyl acylation analyzed by primer extension and mutational profiling (SHAPE-MaP) for direct, versatile and accurate RNA structure analysis. Nature Protocols. 10: 1643-69. PMID 26426499 DOI: 10.1038/Nprot.2015.103  0.615
2015 Kutchko KM, Sanders W, Ziehr B, Phillips G, Solem A, Halvorsen M, Weeks KM, Moorman N, Laederach A. Multiple conformations are a conserved and regulatory feature of the RB1 5' UTR. Rna (New York, N.Y.). 21: 1274-85. PMID 25999316 DOI: 10.1261/Rna.049221.114  0.623
2015 Lavender CA, Gorelick RJ, Weeks KM. Structure-Based Alignment and Consensus Secondary Structures for Three HIV-Related RNA Genomes. Plos Computational Biology. 11: e1004230. PMID 25992893 DOI: 10.1371/Journal.Pcbi.1004230  0.555
2015 Lavender CA, Lorenz R, Zhang G, Tamayo R, Hofacker IL, Weeks KM. Model-Free RNA Sequence and Structure Alignment Informed by SHAPE Probing Reveals a Conserved Alternate Secondary Structure for 16S rRNA. Plos Computational Biology. 11: e1004126. PMID 25992778 DOI: 10.1371/Journal.Pcbi.1004126  0.694
2015 Weeks KM. RNA clubs. Rna (New York, N.Y.). 21: 760-1. PMID 25780225 DOI: 10.1261/rna.050476.115  0.663
2015 Mauger DM, Golden M, Yamane D, Williford S, Lemon SM, Martin DP, Weeks KM. Functionally conserved architecture of hepatitis C virus RNA genomes. Proceedings of the National Academy of Sciences of the United States of America. 112: 3692-7. PMID 25775547 DOI: 10.1073/Pnas.1416266112  0.621
2015 McGinnis JL, Liu Q, Lavender CA, Devaraj A, McClory SP, Fredrick K, Weeks KM. In-cell SHAPE reveals that free 30S ribosome subunits are in the inactive state. Proceedings of the National Academy of Sciences of the United States of America. 112: 2425-30. PMID 25675474 DOI: 10.1073/Pnas.1411514112  0.829
2015 Weeks KM. Review toward all RNA structures, concisely. Biopolymers. 103: 438-48. PMID 25546503 DOI: 10.1002/Bip.22601  0.601
2015 Taylor AI, Pinheiro VB, Smola MJ, Morgunov AS, Peak-Chew S, Cozens C, Weeks KM, Herdewijn P, Holliger P. Catalysts from synthetic genetic polymers. Nature. 518: 427-30. PMID 25470036 DOI: 10.1038/Nature13982  0.464
2014 Rice GM, Busan S, Karabiber F, Favorov OV, Weeks KM. SHAPE analysis of small RNAs and riboswitches. Methods in Enzymology. 549: 165-87. PMID 25432749 DOI: 10.1016/B978-0-12-801122-5.00008-8  0.723
2014 Homan PJ, Tandon A, Rice GM, Ding F, Dokholyan NV, Weeks KM. RNA tertiary structure analysis by 2'-hydroxyl molecular interference. Biochemistry. 53: 6825-33. PMID 25341083 DOI: 10.1021/Bi501218G  0.903
2014 Homan PJ, Favorov OV, Lavender CA, Kursun O, Ge X, Busan S, Dokholyan NV, Weeks KM. Single-molecule correlated chemical probing of RNA. Proceedings of the National Academy of Sciences of the United States of America. 111: 13858-63. PMID 25205807 DOI: 10.1073/Pnas.1407306111  0.904
2014 Siegfried NA, Busan S, Rice GM, Nelson JA, Weeks KM. RNA motif discovery by SHAPE and mutational profiling (SHAPE-MaP). Nature Methods. 11: 959-65. PMID 25028896 DOI: 10.1038/Nmeth.3029  0.723
2014 Low JT, Garcia-Miranda P, Mouzakis KD, Gorelick RJ, Butcher SE, Weeks KM. Structure and dynamics of the HIV-1 frameshift element RNA. Biochemistry. 53: 4282-91. PMID 24926888 DOI: 10.1021/Bi5004926  0.797
2014 McGinnis JL, Weeks KM. Ribosome RNA assembly intermediates visualized in living cells. Biochemistry. 53: 3237-47. PMID 24818530 DOI: 10.1021/Bi500198B  0.91
2014 Warner KD, Homan P, Weeks KM, Smith AG, Abell C, Ferré-D'Amaré AR. Validating fragment-based drug discovery for biological RNAs: lead fragments bind and remodel the TPP riboswitch specifically. Chemistry & Biology. 21: 591-5. PMID 24768306 DOI: 10.1016/J.Chembiol.2014.03.007  0.846
2014 Rice GM, Leonard CW, Weeks KM. RNA secondary structure modeling at consistent high accuracy using differential SHAPE. Rna (New York, N.Y.). 20: 846-54. PMID 24742934 DOI: 10.1261/Rna.043323.113  0.686
2014 Grohman JK, Gorelick RJ, Kottegoda S, Allbritton NL, Rein A, Weeks KM. An immature retroviral RNA genome resembles a kinetically trapped intermediate state. Journal of Virology. 88: 6061-8. PMID 24623442 DOI: 10.1128/Jvi.03277-13  0.902
2013 Tyrrell J, McGinnis JL, Weeks KM, Pielak GJ. The cellular environment stabilizes adenine riboswitch RNA structure. Biochemistry. 52: 8777-85. PMID 24215455 DOI: 10.1021/Bi401207Q  0.876
2013 Busan S, Weeks KM. Role of context in RNA structure: flanking sequences reconfigure CAG motif folding in huntingtin exon 1 transcripts. Biochemistry. 52: 8219-25. PMID 24199621 DOI: 10.1021/Bi401129R  0.549
2013 Archer EJ, Simpson MA, Watts NJ, O'Kane R, Wang B, Erie DA, McPherson A, Weeks KM. Long-range architecture in a viral RNA genome. Biochemistry. 52: 3182-90. PMID 23614526 DOI: 10.1021/Bi4001535  0.649
2013 Pollom E, Dang KK, Potter EL, Gorelick RJ, Burch CL, Weeks KM, Swanstrom R. Comparison of SIV and HIV-1 genomic RNA structures reveals impact of sequence evolution on conserved and non-conserved structural motifs. Plos Pathogens. 9: e1003294. PMID 23593004 DOI: 10.1371/Journal.Ppat.1003294  0.606
2013 Hajdin CE, Bellaousov S, Huggins W, Leonard CW, Mathews DH, Weeks KM. Accurate SHAPE-directed RNA secondary structure modeling, including pseudoknots. Proceedings of the National Academy of Sciences of the United States of America. 110: 5498-503. PMID 23503844 DOI: 10.1073/Pnas.1219988110  0.904
2013 Mauger DM, Siegfried NA, Weeks KM. The genetic code as expressed through relationships between mRNA structure and protein function. Febs Letters. 587: 1180-8. PMID 23499436 DOI: 10.1016/J.Febslet.2013.03.002  0.696
2013 Grohman JK, Gorelick RJ, Lickwar CR, Lieb JD, Bower BD, Znosko BM, Weeks KM. A guanosine-centric mechanism for RNA chaperone function. Science (New York, N.Y.). 340: 190-5. PMID 23470731 DOI: 10.1126/Science.1230715  0.905
2013 Leonard CW, Hajdin CE, Karabiber F, Mathews DH, Favorov OV, Dokholyan NV, Weeks KM. Principles for understanding the accuracy of SHAPE-directed RNA structure modeling. Biochemistry. 52: 588-95. PMID 23316814 DOI: 10.1021/Bi300755U  0.895
2013 Ramachandran S, Ding F, Weeks KM, Dokholyan NV. Statistical analysis of SHAPE-directed RNA secondary structure modeling. Biochemistry. 52: 596-9. PMID 23286327 DOI: 10.1021/Bi300756S  0.535
2013 Karabiber F, McGinnis JL, Favorov OV, Weeks KM. QuShape: rapid, accurate, and best-practices quantification of nucleic acid probing information, resolved by capillary electrophoresis. Rna (New York, N.Y.). 19: 63-73. PMID 23188808 DOI: 10.1261/Rna.036327.112  0.841
2012 Steen KA, Rice GM, Weeks KM. Fingerprinting noncanonical and tertiary RNA structures by differential SHAPE reactivity. Journal of the American Chemical Society. 134: 13160-3. PMID 22852530 DOI: 10.1021/Ja304027M  0.728
2012 Ding F, Lavender CA, Weeks KM, Dokholyan NV. Three-dimensional RNA structure refinement by hydroxyl radical probing. Nature Methods. 9: 603-8. PMID 22504587 DOI: 10.1038/Nmeth.1976  0.754
2012 McGinnis JL, Dunkle JA, Cate JH, Weeks KM. The mechanisms of RNA SHAPE chemistry. Journal of the American Chemical Society. 134: 6617-24. PMID 22475022 DOI: 10.1021/Ja2104075  0.88
2012 Cruz JA, Blanchet MF, Boniecki M, Bujnicki JM, Chen SJ, Cao S, Das R, Ding F, Dokholyan NV, Flores SC, Huang L, Lavender CA, Lisi V, Major F, Mikolajczak K, ... ... Weeks KM, et al. RNA-Puzzles: a CASP-like evaluation of RNA three-dimensional structure prediction. Rna (New York, N.Y.). 18: 610-25. PMID 22361291 DOI: 10.1261/Rna.031054.111  0.645
2012 Low JT, Knoepfel SA, Watts JM, ter Brake O, Berkhout B, Weeks KM. SHAPE-directed discovery of potent shRNA inhibitors of HIV-1. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 820-8. PMID 22314289 DOI: 10.1038/Mt.2011.299  0.818
2012 McGinnis JL, Dunkle JA, Cate JHD, Weeks KM. Correction to The Mechanisms of RNA SHAPE Chemistry Journal of the American Chemical Society. 134: 12319-12319. DOI: 10.1021/Ja306198S  0.888
2012 Tyrrell J, Weeks KM, Pielak GJ. RNA Biophysics in Living Cells using Shape Chemistry Biophysical Journal. 102: 279a. DOI: 10.1016/J.Bpj.2011.11.1543  0.719
2011 Weeks KM, Berkhout B, Bess JW, Datta SA, Gherge C, Gorelick RJ, Knoepfel SA, Leonard CW, Lombo T, Low JT, Rein A, Brake Ot, Watts JM. Applications of RNA structure analysis to retroviral packaging and anti-retroviral therapeutic discovery Retrovirology. 8: 1-1. PMID 22151835 DOI: 10.1186/1742-4690-8-S2-O1  0.887
2011 Grohman JK, Kottegoda S, Gorelick RJ, Allbritton NL, Weeks KM. Femtomole SHAPE reveals regulatory structures in the authentic XMRV RNA genome. Journal of the American Chemical Society. 133: 20326-34. PMID 22126209 DOI: 10.1021/Ja2070945  0.893
2011 Steen KA, Siegfried NA, Weeks KM. Selective 2'-hydroxyl acylation analyzed by protection from exoribonuclease (RNase-detected SHAPE) for direct analysis of covalent adducts and of nucleotide flexibility in RNA. Nature Protocols. 6: 1683-94. PMID 21979276 DOI: 10.1038/Nprot.2011.373  0.74
2011 Weeks KM. RNA structure probing dash seq. Proceedings of the National Academy of Sciences of the United States of America. 108: 10933-4. PMID 21700884 DOI: 10.1073/Pnas.1107835108  0.761
2011 Weeks KM, Mauger DM. Exploring RNA structural codes with SHAPE chemistry. Accounts of Chemical Research. 44: 1280-91. PMID 21615079 DOI: 10.1021/Ar200051H  0.778
2011 Rocca-Serra P, Bellaousov S, Birmingham A, Chen C, Cordero P, Das R, Davis-Neulander L, Duncan CD, Halvorsen M, Knight R, Leontis NB, Mathews DH, Ritz J, Stombaugh J, Weeks KM, et al. Sharing and archiving nucleic acid structure mapping data. Rna (New York, N.Y.). 17: 1204-12. PMID 21610212 DOI: 10.1261/Rna.2753211  0.734
2010 Mauger DM, Weeks KM. Toward global RNA structure analysis. Nature Biotechnology. 28: 1178-9. PMID 21057487 DOI: 10.1038/Nbt1110-1178  0.77
2010 Gherghe C, Lombo T, Leonard CW, Datta SA, Bess JW, Gorelick RJ, Rein A, Weeks KM. Definition of a high-affinity Gag recognition structure mediating packaging of a retroviral RNA genome. Proceedings of the National Academy of Sciences of the United States of America. 107: 19248-53. PMID 20974908 DOI: 10.1073/Pnas.1006897107  0.9
2010 Simon-Loriere E, Martin DP, Weeks KM, Negroni M. RNA structures facilitate recombination-mediated gene swapping in HIV-1. Journal of Virology. 84: 12675-82. PMID 20881047 DOI: 10.1128/Jvi.01302-10  0.557
2010 Steen KA, Malhotra A, Weeks KM. Selective 2'-hydroxyl acylation analyzed by protection from exoribonuclease. Journal of the American Chemical Society. 132: 9940-3. PMID 20597503 DOI: 10.1021/Ja103781U  0.737
2010 Low JT, Weeks KM. SHAPE-directed RNA secondary structure prediction. Methods (San Diego, Calif.). 52: 150-8. PMID 20554050 DOI: 10.1016/J.Ymeth.2010.06.007  0.879
2010 Lavender CA, Ding F, Dokholyan NV, Weeks KM. Robust and generic RNA modeling using inferred constraints: a structure for the hepatitis C virus IRES pseudoknot domain. Biochemistry. 49: 4931-3. PMID 20545364 DOI: 10.1021/Bi100142Y  0.697
2010 Duncan CD, Weeks KM. Nonhierarchical ribonucleoprotein assembly suggests a strain-propagation model for protein-facilitated RNA folding. Biochemistry. 49: 5418-25. PMID 20533823 DOI: 10.1021/Bi100267G  0.894
2010 Hajdin CE, Ding F, Dokholyan NV, Weeks KM. On the significance of an RNA tertiary structure prediction. Rna (New York, N.Y.). 16: 1340-9. PMID 20498460 DOI: 10.1261/Rna.1837410  0.892
2010 Weeks KM. Advances in RNA structure analysis by chemical probing. Current Opinion in Structural Biology. 20: 295-304. PMID 20447823 DOI: 10.1016/J.Sbi.2010.04.001  0.741
2010 Duncan CD, Weeks KM. The Mrs1 splicing factor binds the bI3 group I intron at each of two tetraloop-receptor motifs. Plos One. 5: e8983. PMID 20126554 DOI: 10.1371/Journal.Pone.0008983  0.879
2010 Gherghe C, Leonard CW, Gorelick RJ, Weeks KM. Secondary structure of the mature ex virio Moloney murine leukemia virus genomic RNA dimerization domain. Journal of Virology. 84: 898-906. PMID 19889760 DOI: 10.1128/Jvi.01602-09  0.897
2010 Lavender CA, Ding F, Dokholyan NV, Weeks KM. Correction to Robust and Generic RNA Modeling Using Inferred Constraints: A Structure for the Hepatitis C Virus IRES Pseudoknot Domain Biochemistry. 49: 5968-5968. DOI: 10.1021/Bi100935C  0.556
2009 McGinnis JL, Duncan CD, Weeks KM. High-throughput SHAPE and hydroxyl radical analysis of RNA structure and ribonucleoprotein assembly. Methods in Enzymology. 468: 67-89. PMID 20946765 DOI: 10.1016/S0076-6879(09)68004-6  0.906
2009 Mortimer SA, Weeks KM. Time-resolved RNA SHAPE chemistry: quantitative RNA structure analysis in one-second snapshots and at single-nucleotide resolution. Nature Protocols. 4: 1413-21. PMID 19745823 DOI: 10.1038/Nprot.2009.126  0.729
2009 Mortimer SA, Weeks KM. C2'-endo nucleotides as molecular timers suggested by the folding of an RNA domain. Proceedings of the National Academy of Sciences of the United States of America. 106: 15622-7. PMID 19717440 DOI: 10.1073/Pnas.0901319106  0.703
2009 Watts JM, Dang KK, Gorelick RJ, Leonard CW, Bess JW, Swanstrom R, Burch CL, Weeks KM. Architecture and secondary structure of an entire HIV-1 RNA genome. Nature. 460: 711-6. PMID 19661910 DOI: 10.1038/Nature08237  0.705
2009 Wilkinson KA, Vasa SM, Deigan KE, Mortimer SA, Giddings MC, Weeks KM. Influence of nucleotide identity on ribose 2'-hydroxyl reactivity in RNA. Rna (New York, N.Y.). 15: 1314-21. PMID 19458034 DOI: 10.1261/Rna.1536209  0.744
2009 Mortimer SA, Johnson JS, Weeks KM. Quantitative analysis of RNA solvent accessibility by N-silylation of guanosine. Biochemistry. 48: 2109-14. PMID 19226117 DOI: 10.1021/Bi801939G  0.66
2009 Gherghe CM, Leonard CW, Ding F, Dokholyan NV, Weeks KM. Native-like RNA tertiary structures using a sequence-encoded cleavage agent and refinement by discrete molecular dynamics. Journal of the American Chemical Society. 131: 2541-6. PMID 19193004 DOI: 10.1021/Ja805460E  0.892
2009 Deigan KE, Li TW, Mathews DH, Weeks KM. Accurate SHAPE-directed RNA structure determination. Proceedings of the National Academy of Sciences of the United States of America. 106: 97-102. PMID 19109441 DOI: 10.1073/Pnas.0806929106  0.706
2008 Mortimer SA, Weeks KM. Time-resolved RNA SHAPE chemistry. Journal of the American Chemical Society. 130: 16178-80. PMID 18998638 DOI: 10.1021/Ja8061216  0.755
2008 Vasa SM, Guex N, Wilkinson KA, Weeks KM, Giddings MC. ShapeFinder: a software system for high-throughput quantitative analysis of nucleic acid reactivity information resolved by capillary electrophoresis. Rna (New York, N.Y.). 14: 1979-90. PMID 18772246 DOI: 10.1261/Rna.1166808  0.584
2008 Gherghe CM, Shajani Z, Wilkinson KA, Varani G, Weeks KM. Strong correlation between SHAPE chemistry and the generalized NMR order parameter (S2) in RNA. Journal of the American Chemical Society. 130: 12244-5. PMID 18710236 DOI: 10.1021/Ja804541S  0.891
2008 Duncan CD, Weeks KM. SHAPE analysis of long-range interactions reveals extensive and thermodynamically preferred misfolding in a fragile group I intron RNA. Biochemistry. 47: 8504-13. PMID 18642882 DOI: 10.1021/Bi800207B  0.891
2008 Maity TS, Fried HM, Weeks KM. Anti-cooperative assembly of the SRP19 and SRP68/72 components of the signal recognition particle. The Biochemical Journal. 415: 429-37. PMID 18564060 DOI: 10.1042/Bj20080569  0.682
2008 Gherghe CM, Mortimer SA, Krahn JM, Thompson NL, Weeks KM. Slow conformational dynamics at C2'-endo nucleotides in RNA. Journal of the American Chemical Society. 130: 8884-5. PMID 18558680 DOI: 10.1021/Ja802691E  0.889
2008 Wilkinson KA, Gorelick RJ, Vasa SM, Guex N, Rein A, Mathews DH, Giddings MC, Weeks KM. High-throughput SHAPE analysis reveals structures in HIV-1 genomic RNA strongly conserved across distinct biological states. Plos Biology. 6: e96. PMID 18447581 DOI: 10.1371/Journal.Pbio.0060096  0.66
2008 Jones CN, Wilkinson KA, Hung KT, Weeks KM, Spremulli LL. Lack of secondary structure characterizes the 5' ends of mammalian mitochondrial mRNAs. Rna (New York, N.Y.). 14: 862-71. PMID 18367717 DOI: 10.1261/Rna.909208  0.404
2008 Wang B, Wilkinson KA, Weeks KM. Complex ligand-induced conformational changes in tRNA(Asp) revealed by single-nucleotide resolution SHAPE chemistry. Biochemistry. 47: 3454-61. PMID 18290632 DOI: 10.1021/Bi702372X  0.706
2007 Maity TS, Weeks KM. A threefold RNA-protein interface in the signal recognition particle gates native complex assembly. Journal of Molecular Biology. 369: 512-24. PMID 17434535 DOI: 10.1016/J.Jmb.2007.03.032  0.717
2007 Mortimer SA, Weeks KM. A fast-acting reagent for accurate analysis of RNA secondary and tertiary structure by SHAPE chemistry. Journal of the American Chemical Society. 129: 4144-5. PMID 17367143 DOI: 10.1021/Ja0704028  0.67
2006 Wilkinson KA, Merino EJ, Weeks KM. Selective 2'-hydroxyl acylation analyzed by primer extension (SHAPE): quantitative RNA structure analysis at single nucleotide resolution. Nature Protocols. 1: 1610-6. PMID 17406453 DOI: 10.1038/Nprot.2006.249  0.875
2006 Maity TS, Leonard CW, Rose MA, Fried HM, Weeks KM. Compartmentalization directs assembly of the signal recognition particle. Biochemistry. 45: 14955-64. PMID 17154533 DOI: 10.1021/Bi060890G  0.736
2006 Badorrek CS, Weeks KM. Architecture of a gamma retroviral genomic RNA dimer. Biochemistry. 45: 12664-72. PMID 17042483 DOI: 10.1021/Bi060521K  0.865
2006 Gherghe C, Weeks KM. The SL1-SL2 (stem-loop) domain is the primary determinant for stability of the gamma retroviral genomic RNA dimer. The Journal of Biological Chemistry. 281: 37952-61. PMID 16984912 DOI: 10.1074/Jbc.M607380200  0.866
2006 Badorrek CS, Gherghe CM, Weeks KM. Structure of an RNA switch that enforces stringent retroviral genomic RNA dimerization. Proceedings of the National Academy of Sciences of the United States of America. 103: 13640-5. PMID 16945907 DOI: 10.1073/Pnas.0606156103  0.883
2006 Bokinsky G, Nivón LG, Liu S, Chai G, Hong M, Weeks KM, Zhuang X. Two distinct binding modes of a protein cofactor with its target RNA. Journal of Molecular Biology. 361: 771-84. PMID 16872630 DOI: 10.1016/J.Jmb.2006.06.048  0.726
2006 Li TW, Weeks KM. Structure-independent and quantitative ligation of single-stranded DNA. Analytical Biochemistry. 349: 242-6. PMID 16325753 DOI: 10.1016/J.Ab.2005.11.002  0.402
2005 Badorrek CS, Weeks KM. RNA flexibility in the dimerization domain of a gamma retrovirus. Nature Chemical Biology. 1: 104-11. PMID 16408007 DOI: 10.1038/Nchembio712  0.894
2005 Gherghe CM, Krahn JM, Weeks KM. Crystal structures, reactivity and inferred acylation transition states for 2'-amine substituted RNA. Journal of the American Chemical Society. 127: 13622-8. PMID 16190727 DOI: 10.1021/Ja053647Y  0.842
2005 Merino EJ, Weeks KM. Facile conversion of aptamers into sensors using a 2'-ribose-linked fluorophore. Journal of the American Chemical Society. 127: 12766-7. PMID 16159247 DOI: 10.1021/Ja053189T  0.7
2005 Longo A, Leonard CW, Bassi GS, Berndt D, Krahn JM, Hall TM, Weeks KM. Evolution from DNA to RNA recognition by the bI3 LAGLIDADG maturase. Nature Structural & Molecular Biology. 12: 779-87. PMID 16116439 DOI: 10.1038/Nsmb976  0.633
2005 Wilkinson KA, Merino EJ, Weeks KM. RNA SHAPE chemistry reveals nonhierarchical interactions dominate equilibrium structural transitions in tRNA(Asp) transcripts. Journal of the American Chemical Society. 127: 4659-67. PMID 15796531 DOI: 10.1021/Ja0436749  0.873
2005 Merino EJ, Wilkinson KA, Coughlan JL, Weeks KM. RNA structure analysis at single nucleotide resolution by selective 2'-hydroxyl acylation and primer extension (SHAPE). Journal of the American Chemical Society. 127: 4223-31. PMID 15783204 DOI: 10.1021/Ja043822V  0.868
2004 Buchmueller KL, Weeks KM. Tris-borate is a poor counterion for RNA: a cautionary tale for RNA folding studies. Nucleic Acids Research. 32: e184. PMID 15601995 DOI: 10.1093/Nar/Gnh182  0.907
2004 Garcia I, Weeks KM. Structural basis for the self-chaperoning function of an RNA collapsed state. Biochemistry. 43: 15179-86. PMID 15568809 DOI: 10.1021/Bi048626F  0.827
2004 John DM, Merino EJ, Weeks KM. Mechanics of DNA flexibility visualized by selective 2'-amine acylation at nucleotide bulges. Journal of Molecular Biology. 337: 611-9. PMID 15019781 DOI: 10.1016/J.Jmb.2004.01.029  0.726
2003 Buchmueller KL, Weeks KM. Near native structure in an RNA collapsed state. Biochemistry. 42: 13869-78. PMID 14636054 DOI: 10.1021/Bi035476K  0.891
2003 Merino EJ, Weeks KM. Fluorogenic resolution of ligand binding by a nucleic acid aptamer. Journal of the American Chemical Society. 125: 12370-1. PMID 14531655 DOI: 10.1021/Ja035299A  0.686
2003 Buchmueller KL, Hill BT, Platz MS, Weeks KM. RNA-tethered phenyl azide photocrosslinking via a short-lived indiscriminant electrophile. Journal of the American Chemical Society. 125: 10850-61. PMID 12952464 DOI: 10.1021/Ja035743+  0.888
2003 Bassi GS, Weeks KM. Kinetic and thermodynamic framework for assembly of the six-component bI3 group I intron ribonucleoprotein catalyst. Biochemistry. 42: 9980-8. PMID 12924947 DOI: 10.1021/Bi0346906  0.562
2003 Garcia I, Weeks KM. Small structural costs for evolution from RNA to RNP-based catalysis. Journal of Molecular Biology. 331: 57-73. PMID 12875836 DOI: 10.1016/S0022-2836(03)00686-7  0.823
2003 Chamberlin SI, Weeks KM. Differential helix stabilities and sites pre-organized for tertiary interactions revealed by monitoring local nucleotide flexibility in the bI5 group I intron RNA. Biochemistry. 42: 901-9. PMID 12549908 DOI: 10.1021/Bi026817H  0.889
2002 Chamberlin SI, Merino EJ, Weeks KM. Catalysis of amide synthesis by RNA phosphodiester and hydroxyl groups. Proceedings of the National Academy of Sciences of the United States of America. 99: 14688-93. PMID 12403820 DOI: 10.1073/Pnas.212527799  0.845
2002 John DM, Weeks KM. Chemical interrogation of mismatches in DNA-DNA and DNA-RNA duplexes under nonstringent conditions by selective 2'-amine acylation. Biochemistry. 41: 6866-74. PMID 12022892 DOI: 10.1021/Bi025611D  0.526
2002 Bassi GS, de Oliveira DM, White MF, Weeks KM. Recruitment of intron-encoded and co-opted proteins in splicing of the bI3 group I intron RNA. Proceedings of the National Academy of Sciences of the United States of America. 99: 128-33. PMID 11773622 DOI: 10.1073/Pnas.012579299  0.681
2001 Webb AE, Rose MA, Westhof E, Weeks KM. Protein-dependent transition states for ribonucleoprotein assembly. Journal of Molecular Biology. 309: 1087-100. PMID 11399081 DOI: 10.1006/Jmbi.2001.4714  0.82
2001 Rose MA, Weeks KM. Visualizing induced fit in early assembly of the human signal recognition particle. Nature Structural Biology. 8: 515-20. PMID 11373619 DOI: 10.1038/88577  0.802
2001 Webb AE, Weeks KM. A collapsed state functions to self-chaperone RNA folding into a native ribonucleoprotein complex. Nature Structural Biology. 8: 135-40. PMID 11175902 DOI: 10.1038/84124  0.694
2000 John DM, Weeks KM. Tagging DNA mismatches by selective 2'-amine acylation. Chemistry & Biology. 7: 405-10. PMID 10873837 DOI: 10.1016/S1074-5521(00)00121-6  0.346
2000 Buchmueller KL, Webb AE, Richardson DA, Weeks KM. A collapsed non-native RNA folding state. Nature Structural Biology. 7: 362-6. PMID 10802730 DOI: 10.1038/75125  0.891
2000 Chamberlin SI, Weeks KM. Mapping local nucleotide flexibility by selective acylation of 2'-amine substituted RNA Journal of the American Chemical Society. 122: 216-224. DOI: 10.1021/Ja9914137  0.87
1997 Weeks KM. Protein-facilitated RNA folding. Current Opinion in Structural Biology. 7: 336-42. PMID 9204274 DOI: 10.1016/S0959-440X(97)80048-6  0.678
1996 Weeks KM, Cech TR. Assembly of a ribonucleoprotein catalyst by tertiary structure capture. Science (New York, N.Y.). 271: 345-8. PMID 8553068 DOI: 10.1126/Science.271.5247.345  0.813
1995 Weeks KM, Cech TR. Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5' splice site domain. Cell. 82: 221-30. PMID 7628013 DOI: 10.1016/0092-8674(95)90309-7  0.741
1995 Weeks KM, Cech TR. Efficient protein-facilitated splicing of the yeast mitochondrial bI5 intron. Biochemistry. 34: 7728-38. PMID 7540041 DOI: 10.1021/Bi00023A020  0.585
1993 Weeks KM, Crothers DM. Major groove accessibility of RNA. Science (New York, N.Y.). 261: 1574-7. PMID 7690496 DOI: 10.1126/Science.7690496  0.764
1993 Weeks KM, Crothers DM. RNA targeting by the HIV-1 Tat protein Perspectives in Drug Discovery and Design. 1: 225-234. DOI: 10.1007/Bf02171664  0.77
1992 Weeks KM, Crothers DM. RNA binding assays for Tat-derived peptides: implications for specificity. Biochemistry. 31: 10281-7. PMID 1384694 DOI: 10.1021/Bi00157A015  0.721
1991 Weeks KM, Crothers DM. RNA recognition by Tat-derived peptides: interaction in the major groove? Cell. 66: 577-88. PMID 1907891 DOI: 10.1016/0092-8674(81)90020-9  0.753
1990 Weeks KM, Ampe C, Schultz SC, Steitz TA, Crothers DM. Fragments of the HIV-1 Tat protein specifically bind TAR RNA. Science (New York, N.Y.). 249: 1281-5. PMID 2205002 DOI: 10.1126/Science.2205002  0.784
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