Anu Rambhadran, PhD - Related publications

Affiliations: 
X-Biotech 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Salazar H, Mischke S, Plested AJR. Measurements of the Timescale and Conformational Space of AMPA Receptor Desensitization. Biophysical Journal. PMID 32559412 DOI: 10.1016/j.bpj.2020.05.029   
2020 Bennett KA, Christopher JA, Tehan BG. Structure-based discovery and development of metabotropic glutamate receptor 5 negative allosteric modulators. Advances in Pharmacology (San Diego, Calif.). 88: 35-58. PMID 32416871 DOI: 10.1016/bs.apha.2020.03.001   
2020 Chou TH, Tajima N, Romero-Hernandez A, Furukawa H. Structural Basis of Functional Transitions in Mammalian NMDA Receptors. Cell. PMID 32610085 DOI: 10.1016/j.cell.2020.05.052   
2020 Mattedi G, Acosta-Gutiérrez S, Clark T, Gervasio FL. A combined activation mechanism for the glucagon receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 32571939 DOI: 10.1073/pnas.1921851117   
2020 Olander ER, Janzen D, Villmann C, Jensen AA. Comparison of biophysical properties of α1β2 and α3β2 GABAA receptors in whole-cell patch-clamp electrophysiological recordings. Plos One. 15: e0234080. PMID 32479525 DOI: 10.1371/journal.pone.0234080   
2020 Zhu Z, Yi F, Epplin MP, Liu D, Summer SL, Mizu R, Shaulsky G, XiangWei W, Tang W, Burger PB, Menaldino DS, Myers SJ, Liotta DC, Hansen KB, Yuan H, et al. Negative allosteric modulation of GluN1/GluN3 NMDA receptors. Neuropharmacology. 108117. PMID 32389749 DOI: 10.1016/j.neuropharm.2020.108117   
2020 Perszyk RE, Myers SJ, Yuan H, Gibb AJ, Furukawa H, Sobolevsky AI, Traynelis SF. Hodgkin-huxley-katz prize lecture: genetic and pharmacological control of glutamate receptor channel through a highly conserved gating motif. The Journal of Physiology. PMID 32468591 DOI: 10.1113/JP278086   
2020 Frydenvang K, Pickering DS, Kshirsagar GU, Chemi G, Gemma S, Sprogøe D, Kærn AM, Brogi S, Campiani G, Butini S, Kastrup JS. The ionotropic glutamate receptor GluA2 in complex with bicyclic pyrimidinedione-based compounds: when small compound modifications have distinct effects on binding interactions. Acs Chemical Neuroscience. PMID 32437601 DOI: 10.1021/acschemneuro.0c00195   
2020 Breitinger U, Breitinger HG. Modulators of the inhibitory glycine receptor. Acs Chemical Neuroscience. PMID 32391682 DOI: 10.1021/acschemneuro.0c00054   
2020 McGrath M, Hoyt H, Pence A, Jayakar SS, Zhou X, Forman SA, Cohen JB, Miller KW, Raines DE. Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies. Anesthesiology. PMID 32541553 DOI: 10.1097/ALN.0000000000003403   
2020 Wang Y, Joseph J, Gao Y, Hu B, Geng X, Wu D, Wang J, Zhang F. Revealing the Interaction Modes of 5-HT2A Receptor Antagonists and the Structure-Based Virtual Screening from FDA and TCMNP Database. Journal of Biomolecular Structure & Dynamics. 1-20. PMID 32406337 DOI: 10.1080/07391102.2020.1768900   
2020 Clark LJ, Krieger J, White AD, Bondarenko V, Lei S, Fang F, Lee JY, Doruker P, Böttke T, Jean-Alphonse F, Tang P, Gardella TJ, Xiao K, Sutkeviciute I, Coin I, et al. Allosteric interactions in the parathyroid hormone GPCR-arrestin complex formation. Nature Chemical Biology. PMID 32632293 DOI: 10.1038/s41589-020-0567-0   
2020 Quan J, Ma C, Wang Y, Hu B, Zhang D, Zhang Z, Wang J, Cheng M. Repurposing of cefpodoxime proxetil as potent neuroprotective agent through computational prediction and in vitro validation. Journal of Biomolecular Structure & Dynamics. 1-16. PMID 32448083 DOI: 10.1080/07391102.2020.1772884   
2020 Liu X, Kaindl J, Korczynska M, Stößel A, Dengler D, Stanek M, Hübner H, Clark MJ, Mahoney J, Matt RA, Xu X, Hirata K, Shoichet BK, Sunahara RK, Kobilka BK, et al. An allosteric modulator binds to a conformational hub in the β adrenergic receptor. Nature Chemical Biology. PMID 32483378 DOI: 10.1038/s41589-020-0549-2   
2020 Fuller PJ, Yao YZ, Yang J, Young MJ. Structural determinants of activation of the mineralocorticoid receptor: an evolutionary perspective. Journal of Human Hypertension. PMID 32467588 DOI: 10.1038/s41371-020-0360-2   
2020 Burada AP, Vinnakota R, Kumar J. The Architecture of GluD2 Ionotropic Delta Glutamate Receptor Elucidated by cryo-EM. Journal of Structural Biology. 107546. PMID 32512155 DOI: 10.1016/j.jsb.2020.107546   
2020 Gayton JN, Li Q, Sanders L, Rodrigues RR, Hill G, Delcamp JH. Pyridyl CO Fixation Enabled by a Secondary Hydrogen Bonding Coordination Sphere. Acs Omega. 5: 11687-11694. PMID 32478259 DOI: 10.1021/acsomega.0c00989   
2020 Wasilko DJ, Johnson ZL, Ammirati M, Che Y, Griffor MC, Han S, Wu H. Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20. Nature Communications. 11: 3031. PMID 32541785 DOI: 10.1038/s41467-020-16820-6   
2020 Fischer JP, Els-Heindl S, Beck-Sickinger AG. Adrenomedullin - Current Perspective on a Peptide Hormone with Significant Therapeutic Potential. Peptides. 170347. PMID 32569606 DOI: 10.1016/j.peptides.2020.170347   
2020 Pandey S, Maharana J, Li XX, Woodruff TM, Shukla AK. Emerging Insights into the Structure and Function of Complement C5a Receptors. Trends in Biochemical Sciences. PMID 32402749 DOI: 10.1016/j.tibs.2020.04.004   
2020 Ladurner A, Linder T, Wang L, Hiebl V, Schuster D, Schnürch M, Mihovilovic MD, Atanasov AG, Dirsch VM. Characterization of a Structural Leoligin Analog as Farnesoid X Receptor Agonist and Modulator of Cholesterol Transport. Planta Medica. PMID 32485752 DOI: 10.1055/a-1171-8357   
2020 Soto P, Gaete PS, Fuentes C, Lozano B, Naulin PA, Figueroa XF, Barrera NP. Function of P2X4 Receptors Is Directly Modulated by a 1:1 Stoichiometric Interaction With 5-HTA Receptors. Frontiers in Cellular Neuroscience. 14: 106. PMID 32431598 DOI: 10.3389/fncel.2020.00106   
2020 Roderer D, Bröcker F, Sitsel O, Kaplonek P, Leidreiter F, Seeberger PH, Raunser S. Glycan-dependent cell adhesion mechanism of Tc toxins. Nature Communications. 11: 2694. PMID 32483155 DOI: 10.1038/s41467-020-16536-7   
2020 Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu ZJ. Structural basis of CXC chemokine receptor 2 activation and signalling. Nature. PMID 32610344 DOI: 10.1038/s41586-020-2492-5   
2020 Krintel C, Dorosz J, Larsen AH, Seneca Thorsen T, Venskutonytė R, Mirza O, Gajhede M, Boesen T, Kastrup JS. Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2. The Febs Journal. PMID 32543078 DOI: 10.1111/febs.15455   
2020 Georges GJ, Dengl S, Bujotzek A, Hesse F, Fischer JAA, Gärtner A, Benz J, Lauer ME, Ringler P, Stahlberg H, Plath F, Brinkmann U, Imhof-Jung S. The Contorsbody, an antibody format for agonism: Design, structure, and function. Computational and Structural Biotechnology Journal. 18: 1210-1220. PMID 32542107 DOI: 10.1016/j.csbj.2020.05.007   
2020 Neumann A, Engel V, Mahardhika AB, Schoeder CT, Namasivayam V, Kieć-Kononowicz K, Müller CE. Computational Investigations on the Binding Mode of Ligands for the Cannabinoid-Activated G Protein-Coupled Receptor GPR18. Biomolecules. 10. PMID 32365486 DOI: 10.3390/biom10050686   
2020 Möller J, Isbilir A, Sungkaworn T, Osberg B, Karathanasis C, Sunkara V, Grushevskyi EO, Bock A, Annibale P, Heilemann M, Schütte C, Lohse MJ. Single-molecule analysis reveals agonist-specific dimer formation of µ-opioid receptors. Nature Chemical Biology. PMID 32541966 DOI: 10.1038/s41589-020-0566-1   
2020 Pohl E, Tomlinson CWE. Classical pathways of gene regulation by retinoids. Methods in Enzymology. 637: 151-173. PMID 32359644 DOI: 10.1016/bs.mie.2020.03.008   
2020 Ansell TB, Song W, Sansom MSP. The Glycosphingolipid GM3 Modulates Conformational Dynamics of the Glucagon Receptor. Biophysical Journal. PMID 32610088 DOI: 10.1016/j.bpj.2020.06.009   
2020 Rauschenberger V, Wardenburg NV, Schaefer N, Ogino K, Hirata H, Lillesaar C, Kluck CJ, Meinck HM, Borrmann M, Weishaupt A, Doppler K, Wickel J, Geis C, Sommer C, Villmann C. GlyR autoantibodies impair receptor function and induce motor dysfunction. Annals of Neurology. PMID 32588476 DOI: 10.1002/ana.25832   
2020 Cuellar-Camacho JL, Bhatia S, Reiter-Scherer V, Lauster D, Liese S, Rabe JP, Herrmann A, Haag R. Quantification of multivalent interactions between sialic acid and influenza A virus spike proteins by single molecule force spectroscopy. Journal of the American Chemical Society. PMID 32538085 DOI: 10.1021/jacs.0c02852   
2020 Hellyer SD, Aggarwal S, Chen AN, Leach K, Lapinsky DJ, Gregory KJ. Development of Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 2 Based on Two Positive Allosteric Modulator Chemotypes. Acs Chemical Neuroscience. PMID 32396330 DOI: 10.1021/acschemneuro.0c00009   
2020 Grooms AJ, Neal JF, Ng KC, Zhao W, Flood AH, Allen HC. Thermodynamic Signatures of the Origin of Anti-Hofmeister Selectivity for Phosphate at Aqueous Interfaces. The Journal of Physical Chemistry. A. PMID 32441942 DOI: 10.1021/acs.jpca.0c02515   
2020 Ray M, Nagai K, Kihara Y, Kussrow A, Kammer MN, Frantz A, Bornhop DJ, Chun J. Unlabeled lysophosphatidic acid receptor binding in free solution as determined by a compensated interferometric reader. Journal of Lipid Research. PMID 32513900 DOI: 10.1194/jlr.D120000880   
2020 Perpina-Viciano C, Isbilir A, Zarca A, Caspar B, Kilpatrick LE, Hill SJ, Smit MJ, Lohse MJ, Hoffmann C. Kinetic analysis of the early signaling steps of the human chemokine receptor CXCR4. Molecular Pharmacology. PMID 32474443 DOI: 10.1124/mol.119.118448   
2020 Hellyer SD, Sengmany K, Keller AN, Christopoulos A, Leach K, Gregory KJ. Probe dependence and biased potentiation of metabotropic glutamate receptor 5 is mediated by differential ligand interactions in the common allosteric binding site. Biochemical Pharmacology. 114013. PMID 32389635 DOI: 10.1016/j.bcp.2020.114013   
2020 Brimson JM, Akula KK, Abbas H, Ferry DR, Kulkarni SK, Russell ST, Tisdale MJ, Tencomnao T, Safrany ST. Simple ammonium salts acting on sigma-1 receptors yield potential treatments for cancer and depression. Scientific Reports. 10: 9251. PMID 32514120 DOI: 10.1038/s41598-020-65849-6   
2020 Gao ZG, Toti KS, Campbell R, Suresh RR, Yang H, Jacobson KA. Allosteric Antagonism of the A Adenosine Receptor by a Series of Bitopic Ligands. Cells. 9. PMID 32408534 DOI: 10.3390/cells9051200   
2020 Gurevich VV, Gurevich EV. Biased GPCR signaling: Possible mechanisms and inherent limitations. Pharmacology & Therapeutics. 107540. PMID 32201315 DOI: 10.1016/j.pharmthera.2020.107540   
2020 Liu W, Jiang X, Zu Y, Yang Y, Liu Y, Sun X, Xu Z, Ding H, Zhao Q. A comprehensive description of GluN2B-selective N-methyl-D-aspartate (NMDA) receptor antagonists. European Journal of Medicinal Chemistry. 200: 112447. PMID 32450321 DOI: 10.1016/j.ejmech.2020.112447   
2020 Luo S, Hou Y, Zhang Y, Ma T, Shao W, Xiao C. Adenosine A Receptor Agonist PSB-0777 Modulates Synaptic Proteins and AMPA Receptor Expression in A Dose- and Time-Dependent Manner in Rat Primary Cortical Neurons. Biological & Pharmaceutical Bulletin. PMID 32448843 DOI: 10.1248/bpb.b19-01007   
2020 Schihada H, Ma X, Zabel U, Vischer HF, Schulte G, Leurs R, Pockes S, Lohse MJ. Development of a conformational histamine H receptor biosensor for the synchronous screening of agonists and inverse agonists. Acs Sensors. PMID 32397705 DOI: 10.1021/acssensors.0c00397   
2020 Lindemann M, Moldovan RP, Hinz S, Deuther-Conrad W, Gündel D, Dukic-Stefanovic S, Toussaint M, Teodoro R, Juhl C, Steinbach J, Brust P, Müller CE, Wenzel B. Development of a Radiofluorinated Adenosine A Receptor Antagonist as Potential Ligand for PET Imaging. International Journal of Molecular Sciences. 21. PMID 32366046 DOI: 10.3390/ijms21093197   
2020 Rogers MA, Fantauzzo KA. The emerging complexity of PDGFRs: activation, internalization and signal attenuation. Biochemical Society Transactions. PMID 32369556 DOI: 10.1042/BST20200004   
2020 Dripps IJ, Chen R, Shafer AM, Livingston KE, Disney A, Husbands SM, Traynor JR, Rice KC, Jutkiewicz EM. Pharmacological Properties of Delta Opioid Receptor-Mediated Behaviors: Agonist Efficacy and Receptor Reserve. The Journal of Pharmacology and Experimental Therapeutics. PMID 32467352 DOI: 10.1124/jpet.119.262717   
2020 Park J, Fu Z, Frangaj A, Liu J, Mosyak L, Shen T, Slavkovich VN, Ray KM, Taura J, Cao B, Geng Y, Zuo H, Kou Y, Grassucci R, Chen S, et al. Structure of human GABA receptor in an inactive state. Nature. PMID 32581365 DOI: 10.1038/s41586-020-2452-0   
2020 Zhao B, Li W, Sun L, Fu W. The Use of Computational Approaches in the Discovery and Mechanism Study of Opioid Analgesics. Frontiers in Chemistry. 8: 335. PMID 32500054 DOI: 10.3389/fchem.2020.00335   
2020 Rumpret M, Drylewicz J, Ackermans LJE, Borghans JAM, Medzhitov R, Meyaard L. Functional categories of immune inhibitory receptors. Nature Reviews. Immunology. PMID 32612208 DOI: 10.1038/s41577-020-0352-z   
2020 Burnat G, Brański P, Solich J, Kolasa M, Chruścicka B, Dziedzicka-Wasylewska M, Pilc A. The functional cooperation of 5-HT and mGlu4R in HEK-293 cell line. Pharmacological Reports : Pr. PMID 32472388 DOI: 10.1007/s43440-020-00114-1