Norman R. Klinman - Publications

Affiliations: 
Scripps Research Institute, La Jolla, La Jolla, CA, United States 

83 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2005 Klinman NR. The mechanism of antigenic stimulation of primary and secondary clonal precursor cells. 1972. Journal of Immunology (Baltimore, Md. : 1950). 174: 5161-80. PMID 15843511  0.371
2001 Diaz M, Verkoczy LK, Flajnik MF, Klinman NR. Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase ζ1 Journal of Immunology. 167: 327-335. PMID 11418667 DOI: 10.4049/Jimmunol.167.1.327  0.371
2000 Diaz M, Klinman NR. Relative roles of somatic and Darwinian evolution in shaping the antibody response. Immunologic Research. 21: 89-102. PMID 10852106 DOI: 10.1385/Ir:21:2-3:89  0.573
1998 Klinman NR. Repertoire diversification of primary vs memory B cell subsets. Current Topics in Microbiology and Immunology. 229: 133-148. PMID 9479852 DOI: 10.1007/978-3-642-71984-4_10  0.623
1997 Klinman NR, Kline GH. The B-cell biology of aging Immunological Reviews. 160: 103-114. PMID 9476669 DOI: 10.1111/J.1600-065X.1997.Tb01031.X  0.579
1997 Klinman NR. The cellular origins of memory B cells. Seminars in Immunology. 9: 241-247. PMID 9237930 DOI: 10.1006/Smim.1997.0075  0.57
1997 Klinman N. Introduction: B-cell memory Seminars in Immunology. 9: 217. DOI: 10.1006/Smim.1997.0074  0.447
1996 Linton PJ, Haynes L, Klinman NR, Swain SL. Antigen-independent changes in naive CD4 T cells with aging. Journal of Experimental Medicine. 184: 1891-1900. PMID 8920876 DOI: 10.1084/Jem.184.5.1891  0.405
1996 Klinman NR. The “Clonal Selection Hypothesis” and Current Concepts of B Cell Tolerance Immunity. 5: 189-195. PMID 8808674 DOI: 10.1016/S1074-7613(00)80314-3  0.623
1996 Klinman NR. In Vitro Analysis of the Generation and Propagation of Memory B Cells Immunological Reviews. 150: 91-111. PMID 8782703 DOI: 10.1111/J.1600-065X.1996.Tb00697.X  0.445
1995 Campbell M, Klinman NR. Phosphotyrosine-dependent association between CD22 and protein tyrosine phosphatase 1C. European Journal of Immunology. 25: 1573-1579. PMID 7542197 DOI: 10.1002/Eji.1830250616  0.304
1995 Decker DJ, Linton PJ, Zaharevitz S, Biery M, Gingeras TR, Klinman NR. Defining subsets of naive and memory B cells based on the ability of their progeny to somatically mutate in vitro. Immunity. 2: 195-203. PMID 7534621 DOI: 10.1016/S1074-7613(95)80092-1  0.491
1994 Stillman CA, Linton PJ, Koutz PJ, Decker DJ, Klinman NR, Gingeras TR. Specific immunoglobulin cDNA clones produced from hybridoma cell lines and murine spleen fragment cultures by 3SR amplification. Pcr Methods and Applications. 3: 320-31. PMID 7920236 DOI: 10.1101/Gr.3.6.320  0.579
1994 Klinman NR. Selection in the expression of functionally distinct B-cell subsets. Current Opinion in Immunology. 6: 420-424. PMID 7917109 DOI: 10.1016/0952-7915(94)90121-X  0.573
1993 Koziol JA, Decker DJ, Boyle NE, Klinman NR. The use of Bayesian analysis of PCR-derived genomic DNA sequences to enable a biologically relevant interpretation of immunoglobulin variable region gene expression. Journal of Theoretical Biology. 160: 387-98. PMID 8501914 DOI: 10.1006/Jtbi.1993.1024  0.319
1993 Linton P, Klinman NR. The Use of the Splenic Focus Assay to Study B Cell Tolerance Immunomethods. 2: 95-103. DOI: 10.1006/Immu.1993.1012  0.632
1992 Decker DJ, Klinman NR. Interrelating B cell subpopulations and environmental regulation with the expression of three tiers of repertoire diversity. International Reviews of Immunology. 8: 159-71. PMID 1602210 DOI: 10.3109/08830189209055571  0.579
1992 Linton P, Lo D, Lai L, Thorbecke GJ, Klinman NR. Among naive precursor cell subpopulations only progenitors of memory B cells originate germinal centers. European Journal of Immunology. 22: 1293-1297. PMID 1374340 DOI: 10.1002/Eji.1830220526  0.567
1992 Klinman NR, Urbain JR. Introduction: B Cell Ontogeny and Repertoire Expression Parts I and II International Reviews of Immunology. 8. DOI: 10.3109/08830189209055564  0.501
1990 Klinman NR, Linton P-. The generation of B-cell memory: a working hypothesis. Current Topics in Microbiology and Immunology. 159: 19-35. PMID 2189691 DOI: 10.1007/978-3-642-75244-5_2  0.649
1989 Pinkert CA, Manz J, Linton PJ, Klinman NR, Storb U. Elevated PC responsive B cells and anti-PC antibody production in transgenic mice harboring anti-PC immunoglobulin genes. Veterinary Immunology and Immunopathology. 23: 321-32. PMID 2629197 DOI: 10.1016/0165-2427(89)90144-X  0.505
1989 Linton PJ L, Decker DJ, Klinman NR. Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations. Cell. 59: 1049-59. PMID 2598260 DOI: 10.1016/0092-8674(89)90761-7  0.68
1989 Cooper HM, Klinman NR, Paterson Y. The autoantigenic response to rabbit cytochrome c European Journal of Immunology. 19: 315-322. PMID 2467817 DOI: 10.1002/Eji.1830190215  0.401
1988 Klinman NR, Linton P. The Clonotype Repertoire of B Cell Subpopulations Advances in Immunology. 42: 1-93. PMID 3284288 DOI: 10.1016/S0065-2776(08)60842-1  0.654
1987 Scott DW, Klinman NR. Is tolerance the result of engaging surface Ig of B cells in cycle Immunology Today. 8: 105-106. PMID 25289810 DOI: 10.1016/0167-5699(87)90859-0  0.572
1987 Neil GA, Klinman NR. Repertoire expression in surface immunoglobulin-negative bone marrow B cell precursors. International Reviews of Immunology. 2: 307-20. PMID 3333785 DOI: 10.3109/08830188709044759  0.447
1987 Froscher BG, Klinman NR. Splenic focus assay. Methods in Enzymology. 150: 196-208. PMID 3323780 DOI: 10.1016/0076-6879(87)50077-5  0.68
1986 Riley SC, Connors SJ, Klinman NR, Ogata RT. Preferential expression of variable region heavy chain gene segments by predominant 2,4-dinitrophenyl-specific BALB/c neonatal antibody clonotypes. Proceedings of the National Academy of Sciences of the United States of America. 83: 2589-2593. PMID 3085099 DOI: 10.1073/Pnas.83.8.2589  0.407
1986 Zharhary D, Klinman NR. The frequency and fine specificity of B cells responsive to (4-hydroxy-3-nitrophenyl)acetyl in aged mice. Cellular Immunology. 100: 452-461. PMID 2428512 DOI: 10.1016/0008-8749(86)90044-4  0.563
1985 Jemmerson R, Morrow PR, Klinman NR, Paterson Y. Analysis of an evolutionarily conserved antigenic site on mammalian cytchrome c using synthetic peptides Proceedings of the National Academy of Sciences of the United States of America. 82: 1508-1512. PMID 2579398 DOI: 10.1073/Pnas.82.5.1508  0.326
1985 Froscher BG, Klinman NR. Strain-specific silencing of a predominant antidextran clonotype family. Journal of Experimental Medicine. 162: 1620-1633. PMID 2414388 DOI: 10.1084/Jem.162.5.1620  0.578
1984 Zharhary D, Riley RL, Schaefer M, Klinman N. B-cell ontogeny: Comparison of immature B-cell populations in neonates and adults Annales D'Immunologie. 135: 199-204. PMID 6335013 DOI: 10.1016/S0769-2625(84)81113-7  0.564
1983 Klinman NR, Riley RL, Stone MR. The specificity repertoire of prereceptor and mature B cells Annals of the New York Academy of Sciences. 130-139. PMID 6608899 DOI: 10.1111/J.1749-6632.1983.Tb18061.X  0.79
1983 Klinman NR, Stone MR. Role of variable region gene expression and environmental selection in determining the antiphosphorylcholine B cell repertoire. Journal of Experimental Medicine. 158: 1948-1961. PMID 6606013 DOI: 10.1084/Jem.158.6.1948  0.557
1983 Riley RL, Wylie DE, Klinman NR. B cell repertoire diversification precedes immunoglobulin receptor expression Journal of Experimental Medicine. 158: 1733-1738. PMID 6605409 DOI: 10.1084/Jem.158.5.1733  0.768
1983 Denis KA, Klinman NR. Genetic and temporal control of neonatal antibody expression. Journal of Experimental Medicine. 157: 1170-1183. PMID 6601176 DOI: 10.1084/Jem.157.4.1170  0.637
1983 Sherman LA, Vitiello A, Klinman NR. T-Cell And B-Cell Responses To Viral Antigens At The Clonal Level Annual Review of Immunology. 1: 63-86. PMID 6085789 DOI: 10.1146/Annurev.Iy.01.040183.000431  0.418
1982 Owen JA, Sigal NH, Klinman NR. Heterogeneity of the BALB/c IgM anti-phosphorylcholine antibody response Nature. 295: 347-348. PMID 7057901 DOI: 10.1038/295347A0  0.61
1982 Wylie DE, Sherman LA, Klinman NR. Participation of the major histocompatibility complex in antibody recognition of viral antigens expressed on infected cells. The Journal of Experimental Medicine. 155: 403-14. PMID 6173456 DOI: 10.1084/Jem.155.2.403  0.58
1981 Klinman NR, Wylie DE, Teale JM. B-cell development. Immunology Today. 2: 212-6. PMID 25290455 DOI: 10.1016/0167-5699(81)90049-9  0.623
1981 Klinman NR, Denis KA, Sherman LA. Defining the immune mechanism with monoclonal antibodies. In Vitro Cellular & Developmental Biology – Plant. 17: 1029-1035. PMID 6172363 DOI: 10.1007/Bf02618600  0.678
1981 Pierce SK, Klinman NR. Multiple B cell stimulation by individual antigen-specific T lymphocytes European Journal of Immunology. 11: 71-75. PMID 6163642 DOI: 10.1002/Eji.1830110202  0.752
1980 Cancro MP, Klinman NR. B cell repertoire diversity in athymic mice. The Journal of Experimental Medicine. 151: 761-6. PMID 6965704 DOI: 10.1084/Jem.151.3.761  0.704
1980 Metcalf ES, Scher I, Klinman NR. Susceptibility to in vitro tolerance induction of adult B cells from mice with an X-linked B-cell defect. The Journal of Experimental Medicine. 151: 486-91. PMID 6965400 DOI: 10.1084/Jem.151.2.486  0.755
1980 Teale JM, Klinman NR. Tolerance as an active process. Nature. 288: 385-7. PMID 6159554 DOI: 10.1038/288385A0  0.563
1980 Pierce SK, Klinman NR, Maurer PH, Merryman CF. Role of the major histocompatibility gene products in regulating the antibody response to dinitrophenylated poly(L-Glu55,L-Ala35,L-Phe9)n Journal of Experimental Medicine. 152: 336-349. PMID 6156986 DOI: 10.1084/Jem.152.2.336  0.681
1979 Kennett RH, Denis KA, Tung AS, Klinman NR. Hybrid Plasmacytoma Production: Fusions with Adult Spleen Cells, Monoclonal Spleen Fragments, Neonatal Spleen Cells and Human Spleen Cells Current Topics in Microbiology and Immunology. 81: 77-91. PMID 688763 DOI: 10.1007/978-3-642-67448-8_13  0.562
1979 Metcalf ES, Schrater AF, Klinman NR. Murine models of tolerance induction in developing and mature B cells. Immunological Reviews. 43: 142-83. PMID 365709 DOI: 10.1111/J.1600-065X.1979.Tb00421.X  0.757
1979 Cancro MP, Wylie DE, Gerhard W, Klinman NR. Patterned acquisition of the antibody repertoire: diversity of the hemagglutinin-specific B-cell repertoire in neonatal BALB/c mice. Proceedings of the National Academy of Sciences of the United States of America. 76: 6577-81. PMID 316542 DOI: 10.1073/Pnas.76.12.6577  0.73
1978 Cancro MP, Gerhard W, Klinman NR. The diversity of the influenza-specific primary B-cell repertoire in BALB/c mice. The Journal of Experimental Medicine. 147: 776-87. PMID 416167 DOI: 10.1084/Jem.147.3.776  0.771
1978 Pierce SK, Cancro MP, Klinman NR. Individual antigen-specific T lymphocytes: Helper function in enabling the expression of multiple antibody isotypes Journal of Experimental Medicine. 148: 759-765. PMID 308985 DOI: 10.1084/Jem.148.3.759  0.79
1978 Cancro MP, Sigal NH, Klinman NR. Differential expression of an equivalent clonotype among BALB/c and C57BL/6 mice Journal of Experimental Medicine. 147: 1-12. PMID 75230 DOI: 10.1084/Jem.147.1.1  0.67
1978 Sigal NH, Klinman NR. The B-Cell Clonotype Repertoire Advances in Immunology. 26: 255-337. DOI: 10.1016/S0065-2776(08)60232-1  0.439
1977 Sigal NH, Pickard AR, Metcalf ES, Gearhart PJ, Klinman NR. Expression of phosphorylcholine-specific B cells during murine development Journal of Experimental Medicine. 146: 933-948. PMID 302315 DOI: 10.1084/Jem.146.4.933  0.795
1977 Press JL, Strober S, Klinman NR. Characterization of B cell subpopulations by velocity sedimentation, surface ia antigens and immune function. European Journal of Immunology. 7: 329-35. PMID 302204 DOI: 10.1002/Eji.1830070602  0.842
1977 Pierce SK, Klinman NR. Antibody specific immunoregulation Journal of Experimental Medicine. 146: 509-519. PMID 301552 DOI: 10.1084/Jem.146.2.509  0.736
1977 Accolla RS, Gearhart PJ, Sigal NH, Cancro MP, Klinman NR. Idiotype-specific neonatal suppression of phosphorylcholine-responsive B cells. European Journal of Immunology. 7: 876-81. PMID 75802 DOI: 10.1002/Eji.1830071211  0.797
1977 Metcalf ES, Sigal NH, Klinman NR. In vitro tolerance induction of neonatal murine B cells as a probe for the study of B cell diversification Journal of Experimental Medicine. 145: 1382-1386. PMID 67178 DOI: 10.1084/Jem.145.5.1382  0.802
1977 Gearhart PJ, Sigal NH, Klinman NR. The monoclonal anti phosphorylcholine antibody response in several murine strains: genetic implications of a diverse repertoire Journal of Experimental Medicine. 145: 876-891. PMID 67172 DOI: 10.1084/Jem.145.4.876  0.721
1976 Pierce SK, Klinman NR. Allogeneic carrier specific enhancement of hapten specific secondary B cell responses Journal of Experimental Medicine. 144: 1254-1262. PMID 1086883 DOI: 10.1084/Jem.144.5.1254  0.763
1976 Press JL, Klinman NR, McDevitt HO. Expression of Ia antigens on hapten-specific B cells. I. Delineation of B-cell subpopulations. The Journal of Experimental Medicine. 144: 414-27. PMID 1085328 DOI: 10.1084/Jem.144.2.414  0.851
1976 Sigal NH, Gearhart PJ, Press JL, Klinman NR. Late acquisition of a germ line antibody specificity Nature. 259: 51-52. PMID 1082547 DOI: 10.1038/259051A0  0.563
1976 Klinman NR, Sigal NH, Metcalf ES, Pierce SK, Gearhart PJ. The interplay of evolution and environment in B cell diversification Origins of Lymphocyte Diversity Cold Spring Harbor Symposia On Quantitative Biology. 41: 165-173. PMID 70310 DOI: 10.1101/Sqb.1977.041.01.022  0.844
1975 Gerhard W, Braciale TJ, Klinman NR. The analysis of the monoclonal immune response to influenza virus. I. Production of monoclonal anti viral antibodies in vitro European Journal of Immunology. 5: 720-725. PMID 11993341 DOI: 10.1002/Eji.1830051013  0.741
1975 Gearhart PJ, Sigal NH, Klinman NR. Production of antibodies of identical idiotype but diverse immunoglobulin classes by cells derived from a single stimulated B cell Proceedings of the National Academy of Sciences of the United States of America. 72: 1707-1711. PMID 1080568 DOI: 10.1073/Pnas.72.5.1707  0.725
1975 Pierce SK, Klinman NR. The allogeneic bisection of carrier specific enhancement of monoclonal B cell responses Journal of Experimental Medicine. 142: 1165-1179. PMID 811749 DOI: 10.1084/Jem.142.5.1165  0.778
1975 Klinman NR, Press JL. The B cell specificity repertoire: its relationship to definable subpopulations. Immunological Reviews. 24: 41-83. PMID 49962 DOI: 10.1111/J.1600-065X.1975.Tb00165.X  0.825
1975 Gearhart PJ, Sigal NH, Klinman NR. Heterogeneity of the BALB/c antiphosphorylcholine antibody response at the precursor cell level Journal of Experimental Medicine. 141: 56-71. PMID 46913 DOI: 10.1084/Jem.141.1.56  0.774
1974 Press JL, Klinman NR. Frequency of hapten-specific B cells in neonatal and adult murine spleens. European Journal of Immunology. 4: 155-159. PMID 4546808 DOI: 10.1002/Eji.1830040302  0.822
1973 Press JL, Klinman NR. Isoelectric analysis of neonatal monofocal antibody. Immunochemistry. 10: 621-627. PMID 4796647 DOI: 10.1016/0019-2791(73)90164-X  0.502
1973 Goldstein LT, Klinman NR, Manson LA. A Microtest Radioimmunoassay for Noncytotoxic Tumor-Specific Antibody to Cell-Surface Antigens Journal of the National Cancer Institute. 51: 1713-1715. PMID 4762940 DOI: 10.1093/Jnci/51.5.1713  0.479
1973 Press JL, Klinman NR. Monoclonal production of both IgM and IgG1 antihapten antibody. Journal of Experimental Medicine. 138: 300-305. PMID 4736831 DOI: 10.1084/Jem.138.1.300  0.469
1973 Klinman NR, Press JL, Segal GP. Overlap Stimulation Of Primary And Secondary B Cells By Cross-Reacting Determinants Journal of Experimental Medicine. 138: 1276-1281. PMID 4126771 DOI: 10.1084/Jem.138.5.1276  0.586
1973 Klinman NR, Doughty RA. Hapten-Specific Stimulation Of Secondary B Cells Independent Of T Cells Journal of Experimental Medicine. 138: 473-478. PMID 4124212 DOI: 10.1084/Jem.138.2.473  0.565
1972 Klinman NR. The Mechanism Of Antigenic Stimulation Of Primary And Secondary Clonal Precursor Cells Journal of Experimental Medicine. 136: 241-260. PMID 4114497 DOI: 10.1084/Jem.136.2.241  0.565
1971 Klinman NR. The secondary immune response to a hapten in vitro. Antigen concentration and the carrier effect. Journal of Experimental Medicine. 133: 963-972. PMID 4101805 DOI: 10.1084/Jem.133.5.963  0.564
1967 Klinman NR. Antibody with homogeneous antigen binding produced by splenic foci in organ culture. Immunochemistry. 6: 757-759. PMID 5344479 DOI: 10.1016/0019-2791(67)90140-1  0.422
1967 Wofsy L, Klinman NR, Karush F. Affinity labeling of equine anti-beta-lactoside antibodies. Biochemistry. 6: 1988-91. PMID 4167435 DOI: 10.1021/Bi00859A016  0.669
1967 Klinman NR, Karush F. Equine anti-hapten antibody-V the non-precipitability of bivalent antibody Immunochemistry. 4: 387-405. DOI: 10.1016/0019-2791(67)90098-5  0.71
1965 Klinman NR, Rockey JH, Karush F. Equine antihapten antibody II. The γG(7Sγ) components and their specific interaction Immunochemistry. 2: 51-60. DOI: 10.1016/0019-2791(65)90082-0  0.715
1964 Karush F, Klinman NR, Marks R. An Assay Method For Disulfide Groups By Fluorescence Quenching. Analytical Biochemistry. 9: 100-114. PMID 14246113 DOI: 10.1016/0003-2697(64)90088-0  0.599
1964 Rockey JH, Klinman NR, Karush F. EQUINE ANTIHAPTEN ANTIBODY I. 7S ß2A- AND 10S γ1-GLOBULIN COMPONENTS OF PURIFIED ANTI-ß-LACTOSIDE ANTIBODY Journal of Experimental Medicine. 120: 589-609. PMID 14212122 DOI: 10.1084/Jem.120.4.589  0.713
1964 Klinman NR, Rockey JH, Karush F. Valence And Affinity Of Equine Nonprecipitating Antibody To A Haptenic Group. Science. 146: 401-403. PMID 14186463 DOI: 10.1126/Science.146.3642.401  0.699
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