Robin Ali - Publications

Affiliations: 
Institute of Ophthalmology University College London, London, United Kingdom 

111 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Aldunate EZ, Di Foggia V, Di Marco F, Hervas LA, Ribeiro JC, Holder DL, Patel A, Jannini TB, Thompson DA, Martinez-Barbera JP, Pearson RA, Ali RR, Sowden JC. Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision. Scientific Reports. 9: 2314. PMID 30783126 DOI: 10.1038/s41598-018-38294-9  0.96
2018 Pearson RA, Ali RR. Unlocking the Potential for Endogenous Repair to Restore Sight. Neuron. 100: 524-526. PMID 30408440 DOI: 10.1016/j.neuron.2018.10.035  0.96
2018 Basche M, Kampik D, Kawasaki S, Branch MJ, Robinson M, Larkin F, Smith AJ, Ali RR. Sustained and widespread gene delivery to the corneal epithelium via in situ transduction of limbal epithelial stem cells using lentiviral and AAV vectors. Human Gene Therapy. PMID 30070149 DOI: 10.1089/hum.2018.115  0.8
2018 Ovando-Roche P, West EL, Branch MJ, Sampson RD, Fernando M, Munro P, Georgiadis A, Rizzi M, Kloc M, Naeem A, Ribeiro J, Smith AJ, Gonzalez-Cordero A, Ali RR. Use of bioreactors for culturing human retinal organoids improves photoreceptor yields. Stem Cell Research & Therapy. 9: 156. PMID 29895313 DOI: 10.1186/s13287-018-0907-0  0.84
2018 Mehat MS, Sundaram V, Ripamonti C, Robson AG, Smith AJ, Borooah S, Robinson M, Rosenthal AN, Innes W, Weleber RG, Lee RWJ, Crossland M, Rubin GS, Dhillon B, Steel DHW, ... ... Ali RR, et al. Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in Macular Degeneration. Ophthalmology. PMID 29884405 DOI: 10.1016/j.ophtha.2018.04.037  0.8
2018 Kleine Holthaus SM, Smith AJ, Mole SE, Ali RR. Gene Therapy Approaches to Treat the Neurodegeneration and Visual Failure in Neuronal Ceroid Lipofuscinoses. Advances in Experimental Medicine and Biology. 1074: 91-99. PMID 29721932 DOI: 10.1007/978-3-319-75402-4_12  0.8
2018 Cristante E, Liyanage SE, Sampson RD, Kalargyrou A, De Rossi G, Rizzi M, Hoke J, Ribeiro J, Maswood RN, Duran Y, Matsuki T, Aghaizu N, Luhmann UF, Smith AJ, Ali RR, et al. Late neuroprogenitors contribute to normal retinal vascular development in a-dependent manner. Development (Cambridge, England). PMID 29615467 DOI: 10.1242/dev.157511  0.8
2018 Kleine Holthaus SM, Ribeiro J, Abelleira-Hervas L, Pearson RA, Duran Y, Georgiadis A, Sampson RD, Rizzi M, Hoke J, Maswood R, Azam S, Luhmann UFO, Smith AJ, Mole SE, Ali RR. Prevention of Photoreceptor Cell Loss in a Cln6Mouse Model of Batten Disease Requires CLN6 Gene Transfer to Bipolar Cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29606505 DOI: 10.1016/j.ymthe.2018.02.027  0.96
2018 Gonzalez Cordero A, Goh D, Kruczek K, Naeem A, Fernando M, Kleine Holthaus SM, Takaaki M, Blackford SJI, Kloc M, Agundez L, Sampson RD, Borooah S, Ovando-Roche P, Mehat MS, West EL, ... ... Ali RR, et al. Assessment of AAV vector tropisms for mouse and human pluripotent stem cell-derived RPE and photoreceptor cells. Human Gene Therapy. PMID 29580100 DOI: 10.1089/hum.2018.027  0.96
2018 Kumaran N, Michaelides M, Smith AJ, Ali RR, Bainbridge JWB. Retinal gene therapy. British Medical Bulletin. PMID 29506236 DOI: 10.1093/bmb/ldy005  0.8
2018 Lakowski J, Welby E, Budinger D, Di Marco F, Di Foggia V, Bainbridge JWB, Wallace K, Gamm DM, Ali RR, Sowden JC. Isolation of Human Photoreceptor Precursors via a Cell Surface Marker Panel from Stem Cell-derived Retinal Organoids and Fetal Retinae. Stem Cells (Dayton, Ohio). PMID 29327488 DOI: 10.1002/stem.2775  0.88
2018 Waldron PV, Di Marco F, Kruczek K, Ribeiro J, Graca AB, Hippert C, Aghaizu ND, Kalargyrou AA, Barber AC, Grimaldi G, Duran Y, Blackford SJI, Kloc M, Goh D, Zabala Aldunate E, ... ... Ali RR, et al. Transplanted Donor- or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner. Stem Cell Reports. PMID 29307580 DOI: 10.1016/j.stemcr.2017.12.008  0.96
2017 Welby E, Lakowski J, Di Foggia V, Budinger D, Gonzalez-Cordero A, Lun ATL, Epstein M, Patel A, Cuevas E, Kruczek K, Naeem A, Minneci F, Hubank M, Jones DT, Marioni JC, ... Ali RR, et al. Isolation and Comparative Transcriptome Analysis of Human Fetal and iPSC-Derived Cone Photoreceptor Cells. Stem Cell Reports. PMID 29153988 DOI: 10.1016/j.stemcr.2017.10.018  0.88
2017 Fanelli G, Gonzalez-Cordero A, Gardner PJ, Peng Q, Fernando M, Kloc M, Farrar CA, Naeem A, Garred P, Ali RR, Sacks SH. Human stem cell-derived retinal epithelial cells activate complement via collectin 11 in response to stress. Scientific Reports. 7: 14625. PMID 29116192 DOI: 10.1038/s41598-017-15212-z  0.84
2017 Gonzalez-Cordero A, Kruczek K, Naeem A, Fernando M, Kloc M, Ribeiro J, Goh D, Duran Y, Blackford SJI, Abelleira-Hervas L, Sampson RD, Shum IO, Branch MJ, Gardner PJ, Sowden JC, ... ... Ali RR, et al. Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors. Stem Cell Reports. PMID 28844659 DOI: 10.1016/j.stemcr.2017.07.022  0.96
2017 Ali RR, Auricchio A, Smith AJ. The future looks brighter after 25 years of retinal gene therapy. Human Gene Therapy. PMID 28825330 DOI: 10.1089/hum.2017.164  0.8
2017 Mowat FM, Gervais KJ, Occelli LM, Annear MJ, Querubin J, Bainbridge JW, Smith AJ, Ali RR, Petersen-Jones SM. Early-Onset Progressive Degeneration of the Area Centralis in RPE65-Deficient Dogs. Investigative Ophthalmology & Visual Science. 58: 3268-3277. PMID 28662231 DOI: 10.1167/iovs.17-21930  0.8
2017 Villacampa P, Menger KE, Abelleira L, Ribeiro J, Duran Y, Smith AJ, Ali RR, Luhmann UF, Bainbridge JWB. Accelerated oxygen-induced retinopathy is a reliable model of ischemia-induced retinal neovascularization. Plos One. 12: e0179759. PMID 28650964 DOI: 10.1371/journal.pone.0179759  0.8
2017 Ovando-Roche P, Georgiadis A, Smith AJ, Pearson RA, Ali RR. Harnessing the Potential of Human Pluripotent Stem Cells and Gene Editing for the Treatment of Retinal Degeneration. Current Stem Cell Reports. 3: 112-123. PMID 28596937 DOI: 10.1007/s40778-017-0078-4  0.96
2017 Aghaizu ND, Kruczek K, Gonzalez-Cordero A, Ali RR, Pearson RA. Pluripotent stem cells and their utility in treating photoreceptor degenerations. Progress in Brain Research. 231: 191-223. PMID 28554397 DOI: 10.1016/bs.pbr.2017.01.001  0.96
2017 Kruczek K, Gonzalez-Cordero A, Goh D, Naeem A, Jonikas M, Blackford SJI, Kloc M, Duran Y, Georgiadis A, Sampson RD, Maswood RN, Smith AJ, Decembrini S, Arsenijevic Y, Sowden JC, ... ... Ali RR, et al. Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration. Stem Cell Reports. PMID 28552606 DOI: 10.1016/j.stemcr.2017.04.030  0.96
2017 Gardner PJ, Liyanage SE, Cristante E, Sampson RD, Dick AD, Ali RR, Bainbridge JW. Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye. Scientific Reports. 7: 40830. PMID 28112274 DOI: 10.1038/srep40830  0.36
2017 Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, et al. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Human Molecular Genetics. PMID 28065882 DOI: 10.1093/hmg/ddw387  0.96
2016 Baker AH, Ali RR, Thrasher AJ. Impact of BREXIT on UK Gene and Cell Therapy: The Need for Continued Pan-European Collaboration. Human Gene Therapy. 27: 653-655. PMID 27622542 DOI: 10.1089/hum.2016.29033.ahb  0.88
2016 Liyanage SE, Gardner PJ, Ribeiro J, Cristante E, Sampson RD, Luhmann UF, Ali RR, Bainbridge JW. Flow cytometric analysis of inflammatory and resident myeloid populations in mouse ocular inflammatory models. Experimental Eye Research. PMID 27544307 DOI: 10.1016/j.exer.2016.08.007  0.88
2016 Cartier-Lacave N, Ali R, Ylä-Herttuala S, Kato K, Baetschi B, Lovell-Badge R, Naldini L, Thrasher A. Debate on Germline Gene Editing. Human Gene Therapy Methods. 27: 135-42. PMID 27529507 DOI: 10.1089/hgtb.2016.28999.deb  0.88
2016 Downs LM, Webster AR, Moore AT, Michaelides M, Ali RR, Hardcastle AJ, Mellersh CS. Investigation of SLA4A3 as a candidate gene for human retinal disease. Journal of Negative Results in Biomedicine. 15: 11. PMID 27211793 DOI: 10.1186/s12952-016-0054-z  0.88
2016 Lange C, Mowat F, Sayed H, Mehad M, Duluc L, Piper S, Luhmann U, Nandi M, Kelly P, Smith A, Ali R, Leiper J, Bainbridge J. Dimethylarginine dimethylaminohydrolase-2 deficiency promotes vascular regeneration and attenuates pathological angiogenesis. Experimental Eye Research. PMID 27181226 DOI: 10.1016/j.exer.2016.05.007  0.88
2016 Di Foggia V, Makwana P, Ali RR, Sowden JC. Induced Pluripotent Stem Cell Therapies for Degenerative Disease of the Outer Retina: Disease Modeling and Cell Replacement. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. PMID 27027805 DOI: 10.1089/jop.2015.0143  0.88
2016 Robbie SJ, Georgiadis A, Barker SE, Duran Y, Smith AJ, Ali RR, Luhmann UF, Bainbridge JW. Enhanced Ccl2-Ccr2 signaling drives more severe choroidal neovascularization with aging. Neurobiology of Aging. 40: 110-9. PMID 26973110 DOI: 10.1016/j.neurobiolaging.2015.12.019  0.8
2016 Chu CJ, Gardner PJ, Copland DA, Liyanage SE, Gonzalez-Cordero A, Kleine Holthaus SM, Luhmann UF, Smith AJ, Ali RR, Dick AD. Multimodal analysis of ocular inflammation using the endotoxin-induced uveitis mouse model. Disease Models & Mechanisms. 9: 473-81. PMID 26794131 DOI: 10.1242/dmm.022475  0.88
2016 Liyanage SE, Fantin A, Villacampa P, Lange CA, Denti L, Cristante E, Smith AJ, Ali RR, Luhmann UF, Bainbridge JW, Ruhrberg C. Myeloid-Derived Vascular Endothelial Growth Factor and Hypoxia-Inducible Factor Are Dispensable for Ocular Neovascularization--Brief Report. Arteriosclerosis, Thrombosis, and Vascular Biology. 36: 19-24. PMID 26603154 DOI: 10.1161/ATVBAHA.115.306681  0.8
2015 Ripamonti C, Henning GB, Robbie SJ, Sundaram V, van den Born LI, Casteels I, de Ravel TJ, Moore AT, Smith AJ, Bainbridge JW, Ali RR, Stockman A. Spectral sensitivity measurements reveal partial success in restoring missing rod function with gene therapy. Journal of Vision. 15: 20. PMID 26605849 DOI: 10.1167/15.15.20  0.88
2015 Herrmann P, Cowing JA, Cristante E, Liyanage SE, Ribeiro J, Duran Y, Abelleira Hervas L, Carvalho LS, Bainbridge JW, Luhmann UF, Ali RR. Cd59a deficiency in mice leads to preferential innate immune activation in the retinal pigment epithelium-choroid with age. Neurobiology of Aging. 36: 2637-48. PMID 26234657 DOI: 10.1016/j.neurobiolaging.2015.05.019  0.36
2015 Wu WK, Georgiadis A, Copland DA, Liyanage S, Luhmann UF, Robbie SJ, Liu J, Wu J, Bainbridge JW, Bates DO, Ali RR, Nicholson LB, Dick AD. IL-4 regulates specific Arg-1(+) macrophage sFlt-1-mediated inhibition of angiogenesis. The American Journal of Pathology. 185: 2324-35. PMID 26079814 DOI: 10.1016/j.ajpath.2015.04.013  0.88
2015 Lakowski J, Gonzalez-Cordero A, West EL, Han YT, Welby E, Naeem A, Blackford SJ, Bainbridge JW, Pearson RA, Ali RR, Sowden JC. Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel From Embryonic Stem Cell-Derived Self-Forming Retina. Stem Cells (Dayton, Ohio). 33: 2469-82. PMID 25982268 DOI: 10.1002/stem.2051  0.88
2015 Bainbridge JW, Mehat MS, Sundaram V, Robbie SJ, Barker SE, Ripamonti C, Georgiadis A, Mowat FM, Beattie SG, Gardner PJ, Feathers KL, Luong VA, Yzer S, Balaggan K, Viswanathan A, ... ... Ali RR, et al. Long-term effect of gene therapy on Leber's congenital amaurosis. The New England Journal of Medicine. 372: 1887-97. PMID 25938638 DOI: 10.1056/NEJMoa1414221  0.88
2015 Hippert C, Graca AB, Barber AC, West EL, Smith AJ, Ali RR, Pearson RA. Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific. Plos One. 10: e0120415. PMID 25793273 DOI: 10.1371/journal.pone.0120415  0.88
2015 Thompson DA, Ali RR, Banin E, Branham KE, Flannery JG, Gamm DM, Hauswirth WW, Heckenlively JR, Iannaccone A, Jayasundera KT, Khan NW, Molday RS, Pennesi ME, Reh TA, Weleber RG, et al. Advancing therapeutic strategies for inherited retinal degeneration: recommendations from the Monaciano Symposium. Investigative Ophthalmology & Visual Science. 56: 918-31. PMID 25667399 DOI: 10.1167/iovs.14-16049  0.88
2015 Jayakody SA, Gonzalez-Cordero A, Ali RR, Pearson RA. Cellular strategies for retinal repair by photoreceptor replacement. Progress in Retinal and Eye Research. 46: 31-66. PMID 25660226 DOI: 10.1016/j.preteyeres.2015.01.003  0.88
2015 Yazid S, Gardner PJ, Carvalho L, Chu CJ, Flower RJ, Solito E, Lee RW, Ali RR, Dick AD. Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease. Journal of Autoimmunity. 58: 1-11. PMID 25619792 DOI: 10.1016/j.jaut.2014.12.004  0.88
2015 Nishiguchi KM, Carvalho LS, Rizzi M, Powell K, Holthaus SM, Azam SA, Duran Y, Ribeiro J, Luhmann UF, Bainbridge JW, Smith AJ, Ali RR. Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179. Nature Communications. 6: 6006. PMID 25613321 DOI: 10.1038/ncomms7006  0.88
2015 Luhmann UF, Carvalho LS, Holthaus SM, Cowing JA, Greenaway S, Chu CJ, Herrmann P, Smith AJ, Munro PM, Potter P, Bainbridge JW, Ali RR. The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors. Human Molecular Genetics. 24: 128-41. PMID 25147295 DOI: 10.1093/hmg/ddu424  0.88
2014 Ripamonti C, Henning GB, Ali RR, Bainbridge JW, Robbie SJ, Sundaram V, Luong VA, van den Born LI, Casteels I, de Ravel TJ, Moore AT, Stockman A. Nature of the visual loss in observers with Leber's congenital amaurosis caused by specific mutations in RPE65. Investigative Ophthalmology & Visual Science. 55: 6817-28. PMID 25257057 DOI: 10.1167/iovs.14-14923  0.88
2014 Aboshiha J, Luong V, Cowing J, Dubis AM, Bainbridge JW, Ali RR, Webster AR, Moore AT, Fitzke FW, Michaelides M. Dark-adaptation functions in molecularly confirmed achromatopsia and the implications for assessment in retinal therapy trials. Investigative Ophthalmology & Visual Science. 55: 6340-9. PMID 25168900 DOI: 10.1167/iovs.14-14910  0.88
2014 Aboshiha J, Dubis AM, Cowing J, Fahy RT, Sundaram V, Bainbridge JW, Ali RR, Dubra A, Nardini M, Webster AR, Moore AT, Rubin G, Carroll J, Michaelides M. A prospective longitudinal study of retinal structure and function in achromatopsia. Investigative Ophthalmology & Visual Science. 55: 5733-43. PMID 25103266 DOI: 10.1167/iovs.14-14937  0.88
2014 Luhmann UF, Robbie SJ, Bainbridge JW, Ali RR. The relevance of chemokine signalling in modulating inherited and age-related retinal degenerations. Advances in Experimental Medicine and Biology. 801: 427-33. PMID 24664727 DOI: 10.1007/978-1-4614-3209-8_54  0.36
2014 Ali RR, Hollander AP, Kemp P, Webster A, Wilkins MR. Regulating cell-based regenerative medicine: The challenges ahead Regenerative Medicine. 9: 81-87. PMID 24351008 DOI: 10.2217/rme.13.78  0.88
2014 Warre-Cornish K, Barber AC, Sowden JC, Ali RR, Pearson RA. Migration, integration and maturation of photoreceptor precursors following transplantation in the mouse retina. Stem Cells and Development. 23: 941-54. PMID 24328605 DOI: 10.1089/scd.2013.0471  0.88
2014 Aguilà M, Bevilacqua D, McCulley C, Schwarz N, Athanasiou D, Kanuga N, Novoselov SS, Lange CA, Ali RR, Bainbridge JW, Gias C, Coffey PJ, Garriga P, Cheetham ME. Hsp90 inhibition protects against inherited retinal degeneration. Human Molecular Genetics. 23: 2164-75. PMID 24301679 DOI: 10.1093/hmg/ddt613  0.88
2014 Sundaram V, Wilde C, Aboshiha J, Cowing J, Han C, Langlo CS, Chana R, Davidson AE, Sergouniotis PI, Bainbridge JW, Ali RR, Dubra A, Rubin G, Webster AR, Moore AT, et al. Retinal structure and function in achromatopsia: implications for gene therapy. Ophthalmology. 121: 234-45. PMID 24148654 DOI: 10.1016/j.ophtha.2013.08.017  0.88
2013 Horie S, Robbie SJ, Liu J, Wu WK, Ali RR, Bainbridge JW, Nicholson LB, Mochizuki M, Dick AD, Copland DA. CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization. Scientific Reports. 3: 3072. PMID 24170042 DOI: 10.1038/srep03072  0.36
2013 Annear MJ, Mowat FM, Bartoe JT, Querubin J, Azam SA, Basche M, Curran PG, Smith AJ, Bainbridge JW, Ali RR, Petersen-Jones SM. Successful gene therapy in older Rpe65-deficient dogs following subretinal injection of an adeno-associated vector expressing RPE65. Human Gene Therapy. 24: 883-93. PMID 24028205 DOI: 10.1089/hum.2013.146  0.88
2013 Gonzalez-Cordero A, West EL, Pearson RA, Duran Y, Carvalho LS, Chu CJ, Naeem A, Blackford SJ, Georgiadis A, Lakowski J, Hubank M, Smith AJ, Bainbridge JW, Sowden JC, Ali RR. Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina. Nature Biotechnology. 31: 741-7. PMID 23873086 DOI: 10.1038/nbt.2643  0.88
2013 Chu CJ, Herrmann P, Carvalho LS, Liyanage SE, Bainbridge JW, Ali RR, Dick AD, Luhmann UF. Assessment and in vivo scoring of murine experimental autoimmune uveoretinitis using optical coherence tomography. Plos One. 8: e63002. PMID 23690973 DOI: 10.1371/journal.pone.0063002  0.88
2013 Luhmann UF, Carvalho LS, Robbie SJ, Bainbridge JW, Ali RR. Reply to comment on "Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration" by Luhmann et al. (Exp. Eye Res. 107, February 2013, 80-87). Experimental Eye Research. 111: 136. PMID 23402810 DOI: 10.1016/j.exer.2013.02.001  0.36
2013 Barber AC, Hippert C, Duran Y, West EL, Bainbridge JW, Warre-Cornish K, Luhmann UF, Lakowski J, Sowden JC, Ali RR, Pearson RA. Repair of the degenerate retina by photoreceptor transplantation. Proceedings of the National Academy of Sciences of the United States of America. 110: 354-9. PMID 23248312 DOI: 10.1073/pnas.1212677110  0.88
2013 Luhmann UF, Carvalho LS, Robbie SJ, Cowing JA, Duran Y, Munro PM, Bainbridge JW, Ali RR. Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration. Experimental Eye Research. 107: 80-7. PMID 23232206 DOI: 10.1016/j.exer.2012.11.015  0.88
2013 Petsoglou C, Balaggan KS, Dart JK, Bunce C, Xing W, Ali RR, Tuft SJ. Subconjunctival bevacizumab induces regression of corneal neovascularisation: a pilot randomised placebo-controlled double-masked trial. The British Journal of Ophthalmology. 97: 28-32. PMID 23087419 DOI: 10.1136/bjophthalmol-2012-302137  0.36
2012 Lange CA, Luhmann UF, Mowat FM, Georgiadis A, West EL, Abrahams S, Sayed H, Powner MB, Fruttiger M, Smith AJ, Sowden JC, Maxwell PH, Ali RR, Bainbridge JW. Von Hippel-Lindau protein in the RPE is essential for normal ocular growth and vascular development. Development (Cambridge, England). 139: 2340-50. PMID 22627278 DOI: 10.1242/dev.070813  0.88
2012 West EL, Gonzalez-Cordero A, Hippert C, Osakada F, Martinez-Barbera JP, Pearson RA, Sowden JC, Takahashi M, Ali RR. Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors. Stem Cells (Dayton, Ohio). 30: 1424-35. PMID 22570183 DOI: 10.1002/stem.1123  0.88
2012 Luhmann UF, Lange CA, Robbie S, Munro PM, Cowing JA, Armer HE, Luong V, Carvalho LS, MacLaren RE, Fitzke FW, Bainbridge JW, Ali RR. Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling. Plos One. 7: e35551. PMID 22545116 DOI: 10.1371/journal.pone.0035551  0.88
2012 Tan MH, Mackay DS, Cowing J, Tran HV, Smith AJ, Wright GA, Dev-Borman A, Henderson RH, Moradi P, Russell-Eggitt I, MacLaren RE, Robson AG, Cheetham ME, Thompson DA, Webster AR, ... ... Ali RR, et al. Leber congenital amaurosis associated with AIPL1: challenges in ascribing disease causation, clinical findings, and implications for gene therapy. Plos One. 7: e32330. PMID 22412862 DOI: 10.1371/journal.pone.0032330  0.88
2012 Mowat FM, Gonzalez F, Luhmann UF, Lange CA, Duran Y, Smith AJ, Maxwell PH, Ali RR, Bainbridge JW. Endogenous erythropoietin protects neuroretinal function in ischemic retinopathy. The American Journal of Pathology. 180: 1726-39. PMID 22342523 DOI: 10.1016/j.ajpath.2011.12.033  0.8
2012 Petersen-Jones SM, Annear MJ, Bartoe JT, Mowat FM, Barker SE, Smith AJ, Bainbridge JW, Ali RR. Gene augmentation trials using the Rpe65-deficient dog: contributions towards development and refinement of human clinical trials. Advances in Experimental Medicine and Biology. 723: 177-82. PMID 22183331 DOI: 10.1007/978-1-4614-0631-0_24  0.8
2012 Sundaram V, Moore AT, Ali RR, Bainbridge JW. Educational paper: Retinal dystrophies and gene therapy European Journal of Pediatrics. 171: 757-765. PMID 22080959 DOI: 10.1007/s00431-011-1615-2  0.88
2011 Gualdoni S, Baron M, Lakowski J, Decembrini S, Pearson RA, Ali RR, Sowden JC. Isolation and culture of adult ciliary epithelial cells, previously identified as retinal stem cells, and retinal progenitor cells. Current Protocols in Stem Cell Biology. Unit 1H.4. PMID 22135083 DOI: 10.1002/9780470151808.sc01h04s19  0.96
2011 Shu X, Luhmann UF, Aleman TS, Barker SE, Lennon A, Tulloch B, Chen M, Xu H, Jacobson SG, Ali R, Wright AF. Characterisation of a C1qtnf5 Ser163Arg knock-in mouse model of late-onset retinal macular degeneration. Plos One. 6: e27433. PMID 22110650 DOI: 10.1371/journal.pone.0027433  0.88
2011 Boucherie C, Sowden JC, Ali RR. Induced pluripotent stem cell technology for generating photoreceptors. Regenerative Medicine. 6: 469-79. PMID 21749205 DOI: 10.2217/rme.11.37  0.88
2011 Lange CA, Stavrakas P, Luhmann UF, de Silva DJ, Ali RR, Gregor ZJ, Bainbridge JW. Intraocular oxygen distribution in advanced proliferative diabetic retinopathy. American Journal of Ophthalmology. 152: 406-412.e3. PMID 21723532 DOI: 10.1016/j.ajo.2011.02.014  0.36
2011 Mihelec M, Pearson RA, Robbie SJ, Buch PK, Azam SA, Bainbridge JW, Smith AJ, Ali RR. Long-term preservation of cones and improvement in visual function following gene therapy in a mouse model of leber congenital amaurosis caused by guanylate cyclase-1 deficiency. Human Gene Therapy. 22: 1179-90. PMID 21671801 DOI: 10.1089/hum.2011.069  0.96
2011 Carvalho LS, Xu J, Pearson RA, Smith AJ, Bainbridge JW, Morris LM, Fliesler SJ, Ding XQ, Ali RR. Long-term and age-dependent restoration of visual function in a mouse model of CNGB3-associated achromatopsia following gene therapy. Human Molecular Genetics. 20: 3161-75. PMID 21576125 DOI: 10.1093/hmg/ddr218  0.88
2011 Ali RR, Sowden JC. Regenerative medicine: DIY eye. Nature. 472: 42-3. PMID 21475187 DOI: 10.1038/472042a  0.88
2011 Buch PK, Mihelec M, Cottrill P, Wilkie SE, Pearson RA, Duran Y, West EL, Michaelides M, Ali RR, Hunt DM. Dominant cone-rod dystrophy: a mouse model generated by gene targeting of the GCAP1/Guca1a gene. Plos One. 6: e18089. PMID 21464903 DOI: 10.1371/journal.pone.0018089  0.88
2011 Bartholomae CC, Arens A, Balaggan KS, Yáñez-Muñoz RJ, Montini E, Howe SJ, Paruzynski A, Korn B, Appelt JU, Macneil A, Cesana D, Abel U, Glimm H, Naldini L, Ali RR, et al. Lentiviral vector integration profiles differ in rodent postmitotic tissues. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 703-10. PMID 21364536 DOI: 10.1038/mt.2011.19  0.88
2011 Decembrini S, Cananzi M, Gualdoni S, Battersby A, Allen N, Pearson RA, Ali RR, De Coppi P, Sowden JC. Comparative analysis of the retinal potential of embryonic stem cells and amniotic fluid-derived stem cells. Stem Cells and Development. 20: 851-63. PMID 20939691 DOI: 10.1089/scd.2010.0291  0.96
2010 Georgiadis A, Tschernutter M, Bainbridge JW, Balaggan KS, Mowat F, West EL, Munro PM, Thrasher AJ, Matter K, Balda MS, Ali RR. The tight junction associated signalling proteins ZO-1 and ZONAB regulate retinal pigment epithelium homeostasis in mice. Plos One. 5: e15730. PMID 21209887 DOI: 10.1371/journal.pone.0015730  0.88
2010 West EL, Pearson RA, Barker SE, Luhmann UF, Maclaren RE, Barber AC, Duran Y, Smith AJ, Sowden JC, Ali RR. Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation. Stem Cells (Dayton, Ohio). 28: 1997-2007. PMID 20857496 DOI: 10.1002/stem.520  0.88
2010 Aartsen WM, van Cleef KW, Pellissier LP, Hoek RM, Vos RM, Blits B, Ehlert EM, Balaggan KS, Ali RR, Verhaagen J, Wijnholds J. GFAP-driven GFP expression in activated mouse Müller glial cells aligning retinal blood vessels following intravitreal injection of AAV2/6 vectors. Plos One. 5: e12387. PMID 20808778 DOI: 10.1371/journal.pone.0012387  0.88
2010 Mowat FM, Luhmann UF, Smith AJ, Lange C, Duran Y, Harten S, Shukla D, Maxwell PH, Ali RR, Bainbridge JW. HIF-1alpha and HIF-2alpha are differentially activated in distinct cell populations in retinal ischaemia. Plos One. 5: e11103. PMID 20559438 DOI: 10.1371/journal.pone.0011103  0.8
2010 Gualdoni S, Baron M, Lakowski J, Decembrini S, Smith AJ, Pearson RA, Ali RR, Sowden JC. Adult ciliary epithelial cells, previously identified as retinal stem cells with potential for retinal repair, fail to differentiate into new rod photoreceptors. Stem Cells (Dayton, Ohio). 28: 1048-59. PMID 20506130 DOI: 10.1002/stem.423  0.96
2009 Gabriel R, Eckenberg R, Paruzynski A, Bartholomae CC, Nowrouzi A, Arens A, Howe SJ, Recchia A, Cattoglio C, Wang W, Faber K, Schwarzwaelder K, Kirsten R, Deichmann A, Ball CR, ... ... Ali RR, et al. Comprehensive genomic access to vector integration in clinical gene therapy. Nature Medicine. 15: 1431-6. PMID 19966782 DOI: 10.1038/nm.2057  0.88
2009 Luhmann UF, Robbie S, Munro PM, Barker SE, Duran Y, Luong V, Fitzke FW, Bainbridge JW, Ali RR, MacLaren RE. The drusenlike phenotype in aging Ccl2-knockout mice is caused by an accelerated accumulation of swollen autofluorescent subretinal macrophages. Investigative Ophthalmology & Visual Science. 50: 5934-43. PMID 19578022 DOI: 10.1167/iovs.09-3462  0.88
2009 Barker SE, Broderick CA, Robbie SJ, Duran Y, Natkunarajah M, Buch P, Balaggan KS, MacLaren RE, Bainbridge JW, Smith AJ, Ali RR. Subretinal delivery of adeno-associated virus serotype 2 results in minimal immune responses that allow repeat vector administration in immunocompetent mice. The Journal of Gene Medicine. 11: 486-97. PMID 19340848 DOI: 10.1002/jgm.1327  0.8
2009 Smith AJ, Bainbridge JW, Ali RR. Prospects for retinal gene replacement therapy. Trends in Genetics : Tig. 25: 156-65. PMID 19303164 DOI: 10.1016/j.tig.2009.02.003  0.8
2009 Tan MH, Smith AJ, Pawlyk B, Xu X, Liu X, Bainbridge JB, Basche M, McIntosh J, Tran HV, Nathwani A, Li T, Ali RR. Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV2/2 and AAV2/8 vectors. Human Molecular Genetics. 18: 2099-114. PMID 19299492 DOI: 10.1093/hmg/ddp133  0.8
2008 Mowat FM, Petersen-Jones SM, Williamson H, Williams DL, Luthert PJ, Ali RR, Bainbridge JW. Topographical characterization of cone photoreceptors and the area centralis of the canine retina. Molecular Vision. 14: 2518-27. PMID 19112529  0.36
2008 Bainbridge JW, Smith AJ, Barker SS, Robbie S, Henderson R, Balaggan K, Viswanathan A, Holder GE, Stockman A, Tyler N, Petersen-Jones S, Bhattacharya SS, Thrasher AJ, Fitzke FW, Carter BJ, ... ... Ali RR, et al. Effect of gene therapy on visual function in Leber's congenital amaurosis. The New England Journal of Medicine. 358: 2231-9. PMID 18441371 DOI: 10.1056/NEJMoa0802268  0.88
2007 Khani SC, Pawlyk BS, Bulgakov OV, Kasperek E, Young JE, Adamian M, Sun X, Smith AJ, Ali RR, Li T. AAV-mediated expression targeting of rod and cone photoreceptors with a human rhodopsin kinase promoter. Investigative Ophthalmology & Visual Science. 48: 3954-61. PMID 17724172 DOI: 10.1167/iovs.07-0257  0.88
2007 Yokoi K, Zhang HS, Kachi S, Balaggan KS, Yu Q, Guschin D, Kunis M, Surosky R, Africa LM, Bainbridge JW, Spratt SK, Gregory PD, Ali RR, Campochiaro PA. Gene transfer of an engineered zinc finger protein enhances the anti-angiogenic defense system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1917-23. PMID 17700545 DOI: 10.1038/sj.mt.6300280  0.36
2007 MacNeil A, Pearson RA, MacLaren RE, Smith AJ, Sowden JC, Ali RR. Comparative analysis of progenitor cells isolated from the iris, pars plana, and ciliary body of the adult porcine eye. Stem Cells (Dayton, Ohio). 25: 2430-8. PMID 17600111 DOI: 10.1634/stemcells.2007-0035  0.96
2007 MacLaren RE, Uppal GS, Balaggan KS, Tufail A, Munro PM, Milliken AB, Ali RR, Rubin GS, Aylward GW, da Cruz L. Autologous transplantation of the retinal pigment epithelium and choroid in the treatment of neovascular age-related macular degeneration. Ophthalmology. 114: 561-70. PMID 17324698 DOI: 10.1016/j.ophtha.2006.06.049  0.88
2006 Broderick CA, Smith AJ, Balaggan KS, Georgiadis A, Buch PK, Trittibach PC, Barker SE, Sarra GM, Thrasher AJ, Dick AD, Ali RR. Corrigendum to "Local Administration of an Adeno-Associated Viral Vector Expressing IL-10 Reduces Monocyte Infiltration and Subsequent Photoreceptor Damage During Experimental Autoimmune Uveitis". Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 829. PMID 28189019 DOI: 10.1016/j.ymthe.2005.09.013  0.8
2006 Rolling F, Le Meur G, Stieger K, Smith AJ, Weber M, Deschamps JY, Nivard D, Mendes-Madeira A, Provost N, Péréon Y, Cherel Y, Ali RR, Hamel C, Moullier P, Rolling F. Gene therapeutic prospects in early onset of severe retinal dystrophy: restoration of vision in RPE65 Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented epithelium. Bulletin Et Memoires De L'Academie Royale De Medecine De Belgique. 161: 497-508; discussion . PMID 17503728  0.8
2006 Buch PK, MacLaren RE, Durán Y, Balaggan KS, MacNeil A, Schlichtenbrede FC, Smith AJ, Ali RR. In contrast to AAV-mediated Cntf expression, AAV-mediated Gdnf expression enhances gene replacement therapy in rodent models of retinal degeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 14: 700-9. PMID 16872907 DOI: 10.1016/j.ymthe.2006.05.019  0.8
2006 MacLaren RE, Buch PK, Smith AJ, Balaggan KS, MacNeil A, Taylor JS, Osborne NN, Ali RR. CNTF gene transfer protects ganglion cells in rat retinae undergoing focal injury and branch vessel occlusion. Experimental Eye Research. 83: 1118-27. PMID 16831422 DOI: 10.1016/j.exer.2006.05.019  0.8
2006 Sourisseau T, Georgiadis A, Tsapara A, Ali RR, Pestell R, Matter K, Balda MS. Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA Molecular and Cellular Biology. 26: 2387-2398. PMID 16508013 DOI: 10.1128/MCB.26.6.2387-2398.2006  0.88
2006 Yáñez-Muñoz RJ, Balaggan KS, MacNeil A, Howe SJ, Schmidt M, Smith AJ, Buch P, MacLaren RE, Anderson PN, Barker SE, Duran Y, Bartholomae C, von Kalle C, Heckenlively JR, Kinnon C, ... Ali RR, et al. Effective gene therapy with nonintegrating lentiviral vectors. Nature Medicine. 12: 348-53. PMID 16491086 DOI: 10.1038/nm1365  0.88
2006 Dhomen NS, Balaggan KS, Pearson RA, Bainbridge JW, Levine EM, Ali RR, Sowden JC. Absence of chx10 causes neural progenitors to persist in the adult retina. Investigative Ophthalmology & Visual Science. 47: 386-96. PMID 16384989 DOI: 10.1167/iovs.05-0428  0.88
2006 Surace EM, Balaggan KS, Tessitore A, Mussolino C, Cotugno G, Bonetti C, Vitale A, Ali RR, Auricchio A. Inhibition of ocular neovascularization by hedgehog blockade. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 573-9. PMID 16343995 DOI: 10.1016/j.ymthe.2005.10.010  0.88
2005 Pawlyk BS, Smith AJ, Buch PK, Adamian M, Hong DH, Sandberg MA, Ali RR, Li T. Gene replacement therapy rescues photoreceptor degeneration in a murine model of Leber congenital amaurosis lacking RPGRIP. Investigative Ophthalmology & Visual Science. 46: 3039-45. PMID 16123399 DOI: 10.1167/iovs.05-0371  0.88
2005 Broderick CA, Smith AJ, Balaggan KS, Georgiadis A, Georgarias A, Buch PK, Trittibach PC, Barker SE, Sarra GM, Thrasher AJ, Dick AD, Ali RR. Local administration of an adeno-associated viral vector expressing IL-10 reduces monocyte infiltration and subsequent photoreceptor damage during experimental autoimmune uveitis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 369-73. PMID 16043105 DOI: 10.1016/j.ymthe.2005.03.018  0.8
2005 MacLaren RE, Ali RR, Thrasher AJ. Risks of gene therapy should be weighed against lack of alternatives for many disease [6] British Medical Journal. 330: 791. PMID 15802733  0.88
2005 Guo L, Moss SE, Alexander RA, Ali RR, Fitzke FW, Cordeiro MF. Retinal ganglion cell apoptosis in glaucoma is related to intraocular pressure and IOP-induced effects on extracellular matrix. Investigative Ophthalmology & Visual Science. 46: 175-82. PMID 15623771 DOI: 10.1167/iovs.04-0832  0.88
2004 Hughes EH, Schlichtenbrede FC, Murphy CC, Broderick C, Van Rooijen N, Ali RR, Dick AD. Minocycline delays photoreceptor death in the rds mouse through a microglia-independent mechanism Experimental Eye Research. 78: 1077-1084. PMID 15109914 DOI: 10.1016/j.exer.2004.02.002  0.88
2003 Schlichtenbrede FC, da Cruz L, Stephens C, Smith AJ, Georgiadis A, Thrasher AJ, Bainbridge JWB, Seeliger MW, Ali RR. Long-term evaluation of retinal function in Prph2Rd2/Rd2 mice following AAV-mediated gene replacement therapy Journal of Gene Medicine. 5: 757-764. PMID 12950066 DOI: 10.1002/jgm.401  0.88
2003 Smith AJ, Schlichtenbrede FC, Tschernutter M, Bainbridge JW, Thrasher AJ, Ali RR. AAV-mediated gene transfer slows photoreceptor loss in the RCS rat model of retinitis pigmentosa Molecular Therapy. 8: 188-195. PMID 12907141 DOI: 10.1016/S1525-0016(03)00144-8  0.88
2003 Hughes EH, Schlichtenbrede FC, Murphy CC, Sarra GM, Luthert PJ, Ali RR, Dick AD. Generation of activated sialoadhesin-positive microglia during retinal degeneration Investigative Ophthalmology and Visual Science. 44: 2229-2234. PMID 12714665 DOI: 10.1167/iovs.02-0824  0.88
2003 Bainbridge JW, Jia H, Bagherzadeh A, Selwood D, Ali RR, Zachary I. A peptide encoded by exon 6 of VEGF (EG3306) inhibits VEGF-induced angiogenesis in vitro and ischaemic retinal neovascularisation in vivo. Biochemical and Biophysical Research Communications. 302: 793-9. PMID 12646239  0.36
2003 Bainbridge JWB, Mistry AR, Thrasher AJ, Ali RR. Gene therapy for ocular angiogenesis Clinical Science. 104: 561-575. PMID 12570869 DOI: 10.1042/CS20020314  0.88
2002 Mistry AR, De Alwis M, Feudner E, Ali RR, Thrasher AJ. High-titer stocks of adeno-associated virus from replicating amplicons and herpes vectors Methods in Molecular Medicine. 69: 445-460. PMID 11987794  0.88
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