Victor Tybulewicz - Publications

Affiliations: 
The Francis Crick Institute 

85 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ma D, Cardoso MJ, Zuluaga MA, Modat M, Powell NM, Wiseman FK, Cleary JO, Sinclair B, Harrison IF, Siow B, Popuri K, Lee S, Matsubara JA, Sarunic MV, Beg MF, ... Tybulewicz VLJ, et al. Substantially thinner internal granular layer and reduced molecular layer surface in the cerebellum of the Tc1 mouse model of Down Syndrome - a comprehensive morphometric analysis with active staining contrast-enhanced MRI. Neuroimage. 117271. PMID 32835824 DOI: 10.1016/j.neuroimage.2020.117271  0.68
2020 Lana-Elola E, Watson-Scales S, Slender A, Gibbins D, Martineau A, Douglas C, Mohun T, Fisher EM, Tybulewicz VL. Correction: Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. Elife. 9. PMID 32692312 DOI: 10.7554/eLife.61021  0.92
2020 Thomas JR, LaCombe J, Long R, Lana-Elola E, Watson-Scales S, Wallace JM, Fisher EMC, Tybulewicz VLJ, Roper RJ. Interaction of sexual dimorphism and gene dosage imbalance in skeletal deficits associated with Down syndrome. Bone. 115367. PMID 32305495 DOI: 10.1016/j.bone.2020.115367  0.68
2020 Chang P, Bush D, Schorge S, Good M, Canonica T, Shing N, Noy S, Wiseman FK, Burgess N, Tybulewicz VLJ, Walker MC, Fisher EMC. Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome. Cell Reports. 30: 1152-1163.e4. PMID 31995755 DOI: 10.1016/j.celrep.2019.12.065  0.68
2019 Ahlfors H, Anyanwu N, Pakanavicius E, Dinischiotu N, Lana-Elola E, Watson-Scales S, Tosh J, Wiseman F, Briscoe J, Page K, Fisher EMC, Tybulewicz VLJ. Gene expression dysregulation domains are not a specific feature of Down syndrome. Nature Communications. 10: 2489. PMID 31171815 DOI: 10.1038/s41467-019-10129-9  0.68
2019 Granno S, Nixon-Abell J, Berwick DC, Tosh J, Heaton G, Almudimeegh S, Nagda Z, Rain JC, Zanda M, Plagnol V, Tybulewicz VLJ, Cleverley K, Wiseman FK, Fisher EMC, Harvey K. Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus. Scientific Reports. 9: 7322. PMID 31086297 DOI: 10.1038/s41598-019-43820-4  0.68
2018 Hithersay R, Startin CM, Hamburg S, Mok KY, Hardy J, Fisher EMC, Tybulewicz VLJ, Nizetic D, Strydom A. Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years. Jama Neurology. PMID 30452522 DOI: 10.1001/jamaneurol.2018.3616  0.4
2018 Wiseman FK, Pulford LJ, Barkus C, Liao F, Portelius E, Webb R, Chávez-Gutiérrez L, Cleverley K, Noy S, Sheppard O, Collins T, Powell C, Sarell CJ, Rickman M, Choong X, ... ... Tybulewicz VLJ, et al. Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP. Brain : a Journal of Neurology. PMID 29945247 DOI: 10.1093/brain/awy159  0.68
2018 Watson-Scales S, Kalmar B, Lana-Elola E, Gibbins D, La Russa F, Wiseman F, Williamson M, Saccon R, Slender A, Olerinyova A, Mahmood R, Nye E, Cater H, Wells S, Yu YE, ... ... Tybulewicz VLJ, et al. Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. Plos Genetics. 14: e1007383. PMID 29746474 DOI: 10.1371/journal.pgen.1007383  0.68
2017 Naert G, Ferré V, Keller E, Slender A, Gibbins D, Fisher EM, Tybulewicz VL, Maurice T. In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome. Journal of Psychopharmacology (Oxford, England). 269881117743484. PMID 29215943 DOI: 10.1177/0269881117743484  0.92
2017 Herault Y, Delabar JM, Fisher EMC, Tybulewicz VLJ, Yu E, Brault V. Rodent models in Down syndrome research: impact and future opportunities. Disease Models & Mechanisms. 10: 1165-1186. PMID 28993310 DOI: 10.1242/dmm.029728  0.32
2017 Dekker AD, Vermeiren Y, Albac C, Lana-Elola E, Watson-Scales S, Gibbins D, Aerts T, Van Dam D, Fisher EMC, Tybulewicz VLJ, Potier MC, De Deyn PP. Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models. Neurobiology of Disease. PMID 28624415 DOI: 10.1016/j.nbd.2017.06.007  0.68
2016 Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S, Burr K, Patani R, Rajan R, Sheppard O, Kind PC, ... ... Tybulewicz VL, et al. Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons. Elife. 5. PMID 27692071 DOI: 10.7554/eLife.20337  0.92
2016 Powell NM, Modat M, Cardoso MJ, Ma D, Holmes HE, Yu Y, O'Callaghan J, Cleary JO, Sinclair B, Wiseman FK, Tybulewicz VL, Fisher EM, Lythgoe MF, Ourselin S. Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome. Plos One. 11: e0162974. PMID 27658297 DOI: 10.1371/journal.pone.0162974  0.92
2016 Köchl R, Thelen F, Vanes L, Brazão TF, Fountain K, Xie J, Huang CL, Lyck R, Stein JV, Tybulewicz VL. WNK1 kinase balances T cell adhesion versus migration in vivo. Nature Immunology. PMID 27400149 DOI: 10.1038/ni.3495  0.32
2016 Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, ... ... Tybulewicz VL, et al. A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes. Plos Genetics. 12: e1006033. PMID 27195491 DOI: 10.1371/journal.pgen.1006033  0.32
2016 Karmiloff-Smith A, Al-Janabi T, D'Souza H, Groet J, Massand E, Mok K, Startin C, Fisher E, Hardy J, Nizetic D, Tybulewicz V, Strydom A. The importance of understanding individual differences in Down syndrome. F1000research. 5. PMID 27019699 DOI: 10.12688/f1000research.7506.1  0.4
2016 Hall JH, Wiseman FK, Fisher EM, Tybulewicz VL, Harwood JL, Good MA. Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory. Neurobiology of Learning and Memory. PMID 26868479 DOI: 10.1016/j.nlm.2016.02.002  0.32
2016 Lana-Elola E, Watson-Scales S, Slender A, Gibbins D, Martineau A, Douglas C, Mohun T, Fisher EM, Tybulewicz VLj. Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. Elife. 5. PMID 26765563 DOI: 10.7554/eLife.11614  0.92
2015 Wiseman FK, Al-Janabi T, Hardy J, Karmiloff-Smith A, Nizetic D, Tybulewicz VL, Fisher EM, Strydom A. A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome. Nature Reviews. Neuroscience. 16: 564-74. PMID 26243569 DOI: 10.1038/nrn3983  0.32
2015 Witton J, Padmashri R, Zinyuk LE, Popov VI, Kraev I, Line SJ, Jensen TP, Tedoldi A, Cummings DM, Tybulewicz VL, Fisher EM, Bannerman DM, Randall AD, Brown JT, Edwards FA, et al. Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome. Nature Neuroscience. 18: 1291-8. PMID 26237367 DOI: 10.1038/nn.4072  0.92
2015 Atif SM, Lee SJ, Li LX, Uematsu S, Akira S, Gorjestani S, Lin X, Schweighoffer E, Tybulewicz VL, McSorley SJ. Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9. European Journal of Immunology. 45: 513-24. PMID 25430631 DOI: 10.1002/eji.201444744  0.32
2014 Jacque E, Schweighoffer E, Visekruna A, Papoutsopoulou S, Janzen J, Zillwood R, Tarlinton DM, Tybulewicz VL, Ley SC. IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen. The Journal of Experimental Medicine. 211: 2085-101. PMID 25225457 DOI: 10.1084/jem.20132019  0.32
2014 Hartweger H, Schweighoffer E, Davidson S, Peirce MJ, Wack A, Tybulewicz VL. Themis2 is not required for B cell development, activation, and antibody responses. Journal of Immunology (Baltimore, Md. : 1950). 193: 700-7. PMID 24907343 DOI: 10.4049/jimmunol.1400943  0.32
2014 Ma D, Cardoso MJ, Modat M, Powell N, Wells J, Holmes H, Wiseman F, Tybulewicz V, Fisher E, Lythgoe MF, Ourselin S. Automatic structural parcellation of mouse brain MRI using multi-atlas label fusion. Plos One. 9: e86576. PMID 24475148 DOI: 10.1371/journal.pone.0086576  0.52
2013 Haas MA, Bell D, Slender A, Lana-Elola E, Watson-Scales S, Fisher EMC, Tybulewicz VLJ, Guillemot F. Alterations to dendritic spine morphology, but not dendrite patterning, of cortical projection neurons in Tc1 and Ts1Rhr mouse models of Down syndrome Plos One. 8. PMID 24205261  0.32
2013 Gribble SM, Wiseman FK, Clayton S, Prigmore E, Langley E, Yang F, Maguire S, Fu B, Rajan D, Sheppard O, Scott C, Hauser H, Stephens PJ, Stebbings LA, Ng BL, ... ... Tybulewicz VL, et al. Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of Down syndrome. Plos One. 8: e60482. PMID 23596509 DOI: 10.1371/journal.pone.0060482  0.32
2013 Ahmed MM, Dhanasekaran AR, Tong S, Wiseman FK, Fisher EM, Tybulewicz VL, Gardiner KJ. Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain. Human Molecular Genetics. 22: 1709-24. PMID 23349361 DOI: 10.1093/hmg/ddt017  0.92
2012 Grizenkova J, Akhtar S, Hummerich H, Tomlinson A, Asante EA, Wenborn A, Fizet J, Poulter M, Wiseman FK, Fisher EM, Tybulewicz VL, Brandner S, Collinge J, Lloyd SE. Overexpression of the Hspa13 (Stch) gene reduces prion disease incubation time in mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 13722-7. PMID 22869728 DOI: 10.1073/pnas.1208917109  0.32
2012 Sheppard O, Wiseman FK, Ruparelia A, Tybulewicz VL, Fisher EM. Mouse models of aneuploidy. Thescientificworldjournal. 2012: 214078. PMID 22262951 DOI: 10.1100/2012/214078  0.92
2012 Finney BA, Schweighoffer E, Navarro-Núñez L, Bénézech C, Barone F, Hughes CE, Langan SA, Lowe KL, Pollitt AY, Mourao-Sa D, Sheardown S, Nash GB, Smithers N, Reis e Sousa C, Tybulewicz VL, et al. CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development. Blood. 119: 1747-56. PMID 22186994 DOI: 10.1182/blood-2011-09-380709  0.32
2012 Devoy A, Bunton-Stasyshyn RK, Tybulewicz VL, Smith AJ, Fisher EM. Genomically humanized mice: technologies and promises. Nature Reviews. Genetics. 13: 14-20. PMID 22179716 DOI: 10.1038/nrg3116  0.92
2012 Sheppard O, Plattner F, Rubin A, Slender A, Linehan JM, Brandner S, Tybulewicz VL, Fisher EM, Wiseman FK. Altered regulation of tau phosphorylation in a mouse model of down syndrome aging. Neurobiology of Aging. 33: 828.e31-44. PMID 21843906 DOI: 10.1016/j.neurobiolaging.2011.06.025  0.32
2012 Vidaki M, Tivodar S, Doulgeraki K, Tybulewicz V, Kessaris N, Pachnis V, Karagogeos D. Rac1-dependent cell cycle exit of MGE precursors and GABAergic interneuron migration to the cortex. Cerebral Cortex (New York, N.Y. : 1991). 22: 680-92. PMID 21690261 DOI: 10.1093/cercor/bhr145  0.32
2011 Singleton KL, Gosh M, Dandekar RD, Au-Yeung BB, Ksionda O, Tybulewicz VL, Altman A, Fowell DJ, Wülfing C. Itk controls the spatiotemporal organization of T cell activation. Science Signaling. 4: ra66. PMID 21971040 DOI: 10.1126/scisignal.2001821  0.32
2011 Lana-Elola E, Watson-Scales SD, Fisher EM, Tybulewicz VL. Down syndrome: searching for the genetic culprits. Disease Models & Mechanisms. 4: 586-95. PMID 21878459 DOI: 10.1242/dmm.008078  0.92
2011 Sousa Mda G, Reid DM, Schweighoffer E, Tybulewicz V, Ruland J, Langhorne J, Yamasaki S, Taylor PR, Almeida SR, Brown GD. Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin. Cell Host & Microbe. 9: 436-43. PMID 21575914 DOI: 10.1016/j.chom.2011.04.005  0.32
2011 Cleary JO, Wiseman FK, Norris FC, Price AN, Choy M, Tybulewicz VL, Ordidge RJ, Brandner S, Fisher EM, Lythgoe MF. Structural correlates of active-staining following magnetic resonance microscopy in the mouse brain. Neuroimage. 56: 974-83. PMID 21310249 DOI: 10.1016/j.neuroimage.2011.01.082  0.32
2011 Duchon A, Pothion S, Brault V, Sharp AJ, Tybulewicz VL, Fisher EM, Herault Y. The telomeric part of the human chromosome 21 from Cstb to Prmt2 is not necessary for the locomotor and short-term memory deficits observed in the Tc1 mouse model of Down syndrome. Behavioural Brain Research. 217: 271-81. PMID 21047530 DOI: 10.1016/j.bbr.2010.10.023  0.32
2010 Ruparelia A, Wiseman F, Sheppard O, Tybulewicz VL, Fisher EM. Down syndrome and the molecular pathogenesis resulting from trisomy of human chromosome 21. Journal of Biomedical Research. 24: 87-99. PMID 23554618 DOI: 10.1016/S1674-8301(10)60016-4  0.92
2010 Wiseman FK, Sheppard O, Linehan JM, Brandner S, Tybulewicz VL, Fisher EM. Generation of a panel of antibodies against proteins encoded on human chromosome 21. Journal of Negative Results in Biomedicine. 9: 7. PMID 20727138 DOI: 10.1186/1477-5751-9-7  0.92
2010 De Vita S, Canzonetta C, Mulligan C, Delom F, Groet J, Baldo C, Vanes L, Dagna-Bricarelli F, Hoischen A, Veltman J, Fisher EMC, Tybulewicz VLJ, Nizetic D. Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome Oncogene. 29: 6102-6114. PMID 20697343 DOI: 10.1038/onc.2010.351  0.32
2010 Dunlevy L, Bennett M, Slender A, Lana-Elola E, Tybulewicz VL, Fisher EM, Mohun T. Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse. Cardiovascular Research. 88: 287-95. PMID 20558441 DOI: 10.1093/cvr/cvq193  0.92
2010 Reynolds LE, Watson AR, Baker M, Jones TA, D'Amico G, Robinson SD, Joffre C, Garrido-Urbani S, Rodriguez-Manzaneque JC, Martino-Echarri E, Aurrand-Lions M, Sheer D, Dagna-Bricarelli F, Nizetic D, McCabe CJ, ... ... Tybulewicz VL, et al. Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome. Nature. 465: 813-7. PMID 20535211 DOI: 10.1038/nature09106  0.32
2010 D'Amico G, Robinson SD, Germain M, Reynolds LE, Thomas GJ, Elia G, Saunders G, Fruttiger M, Tybulewicz V, Mavria G, Hodivala-Dilke KM. Endothelial-Rac1 is not required for tumor angiogenesis unless alphavbeta3-integrin is absent. Plos One. 5: e9766. PMID 20339539 DOI: 10.1371/journal.pone.0009766  0.32
2010 Henderson RB, Grys K, Vehlow A, De Bettignies C, Zachacz A, Henley T, Turner M, Batista F, Tybulewicz VLJ. A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival Journal of Experimental Medicine. 207: 837-853. PMID 20308364 DOI: 10.1084/jem.20091489  0.32
2010 Alford KA, Slender A, Vanes L, Li Z, Fisher EM, Nizetic D, Orkin SH, Roberts I, Tybulewicz VL. Perturbed hematopoiesis in the Tc1 mouse model of Down syndrome. Blood. 115: 2928-37. PMID 20154221 DOI: 10.1182/blood-2009-06-227629  0.92
2009 D'Amico G, Jones DT, Nye E, Sapienza K, Ramjuan AR, Reynolds LE, Robinson SD, Kostourou V, Martinez D, Aubyn D, Grose R, Thomas GJ, Spencer-Dene B, Zicha D, Davies D, ... Tybulewicz V, et al. Regulation of lymphatic-blood vessel separation by endothelial Rac1. Development (Cambridge, England). 136: 4043-53. PMID 19906871 DOI: 10.1242/dev.035014  0.32
2009 Fisher EMC, Lana-Elola E, Watson SD, Vassiliou G, Tybulewicz VLJ. New approaches for modelling sporadic genetic disease in the mouse Dmm Disease Models and Mechanisms. 2: 446-453. PMID 19726804 DOI: 10.1242/dmm.001644  0.32
2009 Robinson MJ, Osorio F, Rosas M, Freitas RP, Schweighoffer E, Gross O, Verbeek JS, Ruland J, Tybulewicz V, Brown GD, Moita LF, Taylor PR, Reis e Sousa C. Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection. The Journal of Experimental Medicine. 206: 2037-51. PMID 19703985 DOI: 10.1084/jem.20082818  0.32
2009 Wiseman FK, Alford KA, Tybulewicz VL, Fisher EM. Down syndrome--recent progress and future prospects. Human Molecular Genetics. 18: R75-83. PMID 19297404 DOI: 10.1093/hmg/ddp010  0.92
2009 Galante M, Jani H, Vanes L, Daniel H, Fisher EM, Tybulewicz VL, Bliss TV, Morice E. Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndrome. Human Molecular Genetics. 18: 1449-63. PMID 19181682 DOI: 10.1093/hmg/ddp055  0.32
2009 Sriskantharajah S, Belich MP, Papoutsopoulou S, Janzen J, Tybulewicz V, Seddon B, Ley SC. Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation. Nature Immunology. 10: 38-47. PMID 19060899 DOI: 10.1038/ni.1685  0.32
2009 Wang Y, Mulligan C, Denyer G, Delom F, Dagna-Bricarelli F, Tybulewicz VL, Fisher EM, Griffiths WJ, Nizetic D, Groet J. Quantitative proteomics characterization of a mouse embryonic stem cell model of Down syndrome. Molecular & Cellular Proteomics : McP. 8: 585-95. PMID 19001410 DOI: 10.1074/mcp.M800256-MCP200  0.92
2008 Wilson MD, Barbosa-Morais NL, Schmidt D, Conboy CM, Vanes L, Tybulewicz VL, Fisher EM, Tavaré S, Odom DT. Species-specific transcription in mice carrying human chromosome 21. Science (New York, N.Y.). 322: 434-8. PMID 18787134 DOI: 10.1126/science.1160930  0.92
2008 Canzonetta C, Mulligan C, Deutsch S, Ruf S, O'Doherty A, Lyle R, Borel C, Lin-Marq N, Delom F, Groet J, Schnappauf F, De Vita S, Averill S, Priestley JV, Martin JE, ... ... Tybulewicz VL, et al. DYRK1A-dosage imbalance perturbs NRSF/REST levels, deregulating pluripotency and embryonic stem cell fate in Down syndrome. American Journal of Human Genetics. 83: 388-400. PMID 18771760 DOI: 10.1016/j.ajhg.2008.08.012  0.32
2008 Morice E, Andreae LC, Cooke SF, Vanes L, Fisher EM, Tybulewicz VL, Bliss TV. Preservation of long-term memory and synaptic plasticity despite short-term impairments in the Tc1 mouse model of Down syndrome. Learning & Memory (Cold Spring Harbor, N.Y.). 15: 492-500. PMID 18626093 DOI: 10.1101/lm.969608  0.32
2008 Liang B, Workman C, Lee J, Chew C, Dale BM, Colonna L, Flores M, Li N, Schweighoffer E, Greenberg S, Tybulewicz V, Vignali D, Clynes R. Regulatory T cells inhibit dendritic cells by lymphocyte activation gene-3 engagement of MHC class II. Journal of Immunology (Baltimore, Md. : 1950). 180: 5916-26. PMID 18424711  0.32
2008 Dennehy KM, Ferwerda G, Faro-Trindade I, Pyz E, Willment JA, Taylor PR, Kerrigan A, Tsoni SV, Gordon S, Meyer-Wentrup F, Adema GJ, Kullberg BJ, Schweighoffer E, Tybulewicz V, Mora-Montes HM, et al. Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors. European Journal of Immunology. 38: 500-6. PMID 18200499 DOI: 10.1002/eji.200737741  0.32
2008 Depoil D, Fleire S, Treanor BL, Weber M, Harwood NE, Marchbank KL, Tybulewicz VL, Batista FD. CD19 is essential for B cell activation by promoting B cell receptor-antigen microcluster formation in response to membrane-bound ligand. Nature Immunology. 9: 63-72. PMID 18059271 DOI: 10.1038/ni1547  0.32
2007 Mensah A, Mulligan C, Linehan J, Ruf S, O'Doherty A, Grygalewicz B, Shipley J, Groet J, Tybulewicz V, Fisher E, Brandner S, Nizetic D. An additional human chromosome 21 causes suppression of neural fate of pluripotent mouse embryonic stem cells in a teratoma model. Bmc Developmental Biology. 7: 131. PMID 18047653 DOI: 10.1186/1471-213X-7-131  0.4
2007 Ramaswamy M, Dumont C, Cruz AC, Muppidi JR, Gomez TS, Billadeau DD, Tybulewicz VL, Siegel RM. Cutting edge: Rac GTPases sensitize activated T cells to die via Fas. Journal of Immunology (Baltimore, Md. : 1950). 179: 6384-8. PMID 17982024  0.32
2007 Kissil JL, Walmsley MJ, Hanlon L, Haigis KM, Bender Kim CF, Sweet-Cordero A, Eckman MS, Tuveson DA, Capobianco AJ, Tybulewicz VL, Jacks T. Requirement for Rac1 in a K-ras induced lung cancer in the mouse. Cancer Research. 67: 8089-94. PMID 17804720 DOI: 10.1158/0008-5472.CAN-07-2300  0.32
2007 Nodari A, Zambroni D, Quattrini A, Court FA, D'Urso A, Recchia A, Tybulewicz VLJ, Wrabetz L, Feltri ML. β1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination Journal of Cell Biology. 177: 1063-1075. PMID 17576799 DOI: 10.1083/jcb.200610014  0.32
2006 Tybulewicz VL, Fisher EM. New techniques to understand chromosome dosage: mouse models of aneuploidy. Human Molecular Genetics. 15: R103-9. PMID 16987872 DOI: 10.1093/hmg/ddl179  0.92
2006 Wheeler AP, Wells CM, Smith SD, Vega FM, Henderson RB, Tybulewicz VL, Ridley AJ. Rac1 and Rac2 regulate macrophage morphology but are not essential for migration. Journal of Cell Science. 119: 2749-57. PMID 16772332 DOI: 10.1242/jcs.03024  0.32
2006 Papoutsopoulou S, Symons A, Tharmalingham T, Belich MP, Kaiser F, Kioussis D, O'Garra A, Tybulewicz V, Ley SC. ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses. Nature Immunology. 7: 606-15. PMID 16633345 DOI: 10.1038/ni1334  0.32
2005 McCarty OJ, Larson MK, Auger JM, Kalia N, Atkinson BT, Pearce AC, Ruf S, Henderson RB, Tybulewicz VL, Machesky LM, Watson SP. Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. The Journal of Biological Chemistry. 280: 39474-84. PMID 16195235 DOI: 10.1074/jbc.M504672200  0.32
2005 O'Doherty A, Ruf S, Mulligan C, Hildreth V, Errington ML, Cooke S, Sesay A, Modino S, Vanes L, Hernandez D, Linehan JM, Sharpe PT, Brandner S, Bliss TV, Henderson DJ, ... ... Tybulewicz VL, et al. An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes. Science (New York, N.Y.). 309: 2033-7. PMID 16179473 DOI: 10.1126/science.1114535  0.32
2005 Wells CM, Bhavsar PJ, Evans IR, Vigorito E, Turner M, Tybulewicz V, Ridley AJ. Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization Experimental Cell Research. 310: 303-310. PMID 16137676 DOI: 10.1016/j.yexcr.2005.07.015  0.32
2004 Benvenuti F, Hugues S, Walmsley M, Ruf S, Fetler L, Popoff M, Tybulewicz VL, Amigorena S. Requirement of Rac1 and Rac2 expression by mature dendritic cells for T cell priming. Science (New York, N.Y.). 305: 1150-3. PMID 15326354 DOI: 10.1126/science.1099159  0.32
2004 Meade J, Tybulewicz VLJ, Turner M. The tyrosine kinase Syk is required for light chain isotype exclusion but dispensable for the negative selection of B cells European Journal of Immunology. 34: 1102-1110. PMID 15048721 DOI: 10.1002/eji.200324309  0.32
2003 Zompi S, Hamerman JA, Ogasawara K, Schweighoffer E, Tybulewicz VL, Di Santo JP, Lanier LL, Colucci F. NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases. Nature Immunology. 4: 565-72. PMID 12740576 DOI: 10.1038/ni930  0.32
2003 Abtahian F, Guerriero A, Sebzda E, Lu MM, Zhou R, Mocsai A, Myers EE, Huang B, Jackson DG, Ferrari VA, Tybulewicz V, Lowell CA, Lepore JJ, Koretzky GA, Kahn ML. Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science (New York, N.Y.). 299: 247-51. PMID 12522250 DOI: 10.1126/science.1079477  0.32
1999 Pasquet JM, Gross B, Quek L, Asazuma N, Zhang W, Sommers CL, Schweighoffer E, Tybulewicz V, Judd B, Lee JR, Koretzky G, Love PE, Samelson LE, Watson SP. LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI. Molecular and Cellular Biology. 19: 8326-34. PMID 10567557 DOI: 10.1128/MCB.19.12.8326  0.32
1999 Gross BS, Lee JR, Clements JL, Turner M, Tybulewicz VL, Findell PR, Koretzky GA, Watson SP. Tyrosine phosphorylation of SLP-76 is downstream of Syk following stimulation of the collagen receptor in platelets. The Journal of Biological Chemistry. 274: 5963-71. PMID 10026222 DOI: 10.1074/jbc.274.9.5963  0.32
1998 O'Rourke LM, Tooze R, Turner M, Sandoval DM, Carter RH, Tybulewicz VLJ, Fearon DT. CD19 as a membrane-anchored adaptor protein of B lymphocytes: Costimulation of lipid and protein kinases by recruitment of Vav Immunity. 8: 635-645. PMID 9620684 DOI: 10.1016/S1074-7613(00)80568-3  0.32
1997 Melford SK, Turner M, Briddon SJ, Tybulewicz VLJ, Watson SP. Syk and Fyn are required by mouse megakaryocytes for the rise in intracellular calcium induced by a collagen-related peptide Journal of Biological Chemistry. 272: 27539-27542. PMID 9346887 DOI: 10.1074/jbc.272.44.27539  0.32
1997 Crowley MT, Costello PS, Fitzer-Attas CJ, Turner M, Meng F, Lowell C, Tybulewicz VL, DeFranco AL. A critical role for Syk in signal transduction and phagocytosis mediated by Fcgamma receptors on macrophages. The Journal of Experimental Medicine. 186: 1027-39. PMID 9314552 DOI: 10.1084/jem.186.7.1027  0.32
1994 Karaplis AC, Luz A, Glowacki J, Bronson RT, Tybulewicz VL, Kronenberg HM, Mulligan RC. Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene. Genes & Development. 8: 277-89. PMID 8314082 DOI: 10.1101/gad.8.3.277  0.32
1991 Tybulewicz VLJ, Crawford CE, Jackson PK, Bronson RT, Mulligan RC. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene Cell. 65: 1153-1163. PMID 2065352 DOI: 10.1016/0092-8674(91)90011-M  0.32
1986 Gay NJ, Tybulewicz VL, Walker JE. Insertion of transposon Tn7 into the Escherichia coli glmS transcriptional terminator. The Biochemical Journal. 234: 111-7. PMID 3010949 DOI: 10.1042/bj2340111  0.44
1985 Walker JE, Fearnley IM, Gay NJ, Gibson BW, Northrop FD, Powell SJ, Runswick MJ, Saraste M, Tybulewicz VL. Primary structure and subunit stoichiometry of F1-ATPase from bovine mitochondria. Journal of Molecular Biology. 184: 677-701. PMID 2864455 DOI: 10.1016/0022-2836(85)90313-4  0.44
1984 Walker JE, Falk G, Gay NJ, Tybulewicz VL. Genes for bacterial and mitochondrial ATP synthase. Biochemical Society Transactions. 12: 234-5. PMID 6233197 DOI: 10.1042/bst0120234  0.44
1984 Tybulewicz VL, Falk G, Walker JE. Rhodopseudomonas blastica atp operon. Nucleotide sequence and transcription. Journal of Molecular Biology. 179: 185-214. PMID 6209404 DOI: 10.1016/0022-2836(84)90465-0  0.44
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