Nikhil Panicker, PhD - Publications

Affiliations: 
2009-2016 Biomedical science Iowa State University, Ames, IA, United States 
 2016-2022 Johns Hopkins University School of Medicine, Baltimore, MD, United States 
 2022- Neurosciences Cleveland Clinic Foundation, Cleveland, OH, United States 

24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Singh J, Habean ML, Panicker N. Inflammasome assembly in neurodegenerative diseases. Trends in Neurosciences. 46: 814-831. PMID 37633753 DOI: 10.1016/j.tins.2023.07.009  0.464
2022 Patel J, Panicker N, Dawson VL, Dawson TM. Cell Biology of Parkin: Clues to the Development of New Therapeutics for Parkinson's Disease. Cns Drugs. 36: 1249-1267. PMID 36378485 DOI: 10.1007/s40263-022-00973-7  0.589
2022 Panicker N, Kam TI, Wang H, Neifert S, Chou SC, Kumar M, Brahmachari S, Jhaldiyal A, Hinkle JT, Akkentli F, Mao X, Xu E, Karuppagounder SS, Hsu ET, Kang SU, et al. Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease. Neuron. PMID 35654037 DOI: 10.1016/j.neuron.2022.05.009  0.825
2022 Hinkle JT, Patel J, Panicker N, Karuppagounder SS, Biswas D, Belingon B, Chen R, Brahmachari S, Pletnikova O, Troncoso JC, Dawson VL, Dawson TM. STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy. Proceedings of the National Academy of Sciences of the United States of America. 119: e2118819119. PMID 35394877 DOI: 10.1073/pnas.2118819119  0.835
2022 Pirooznia SK, Wang H, Panicker N, Kumar M, Neifert S, Dar MA, Lau E, Kang BG, Redding-Ochoa J, Troncoso JC, Dawson VL, Dawson TM. Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease. Science Advances. 8: eabh1824. PMID 35363524 DOI: 10.1126/sciadv.abh1824  0.687
2021 Panicker N, Ge P, Dawson VL, Dawson TM. The cell biology of Parkinson's disease. The Journal of Cell Biology. 220. PMID 33749710 DOI: 10.1083/jcb.202012095  0.806
2020 Sarkar S, Nguyen HM, Malovic E, Luo J, Langley M, Palanisamy BN, Singh N, Manne S, Neal M, Gabrielle M, Abdalla A, Anantharam P, Rokad D, Panicker N, Singh V, et al. Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease. The Journal of Clinical Investigation. PMID 32597830 DOI: 10.1172/Jci136174  0.806
2020 Saminathan H, Charli A, Luo J, Panicker N, Gordon R, Hostetter JM, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A. Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research. European Journal of Pharmacology. 173259. PMID 32565338 DOI: 10.1016/J.Ejphar.2020.173259  0.791
2020 Panicker N, Kam T, Neifert S, Hinkle J, Mao X, Karuppagounder S, Wang H, Kumar M, Pirooznia S, Pletnikova O, Troncoso J, Dawson VL, Dawson TM. NLRP3 inflammasome activation in dopamine neurons contributes to neurodegeneration in Parkinson’s Disease The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.01881  0.8
2019 Panicker N, Kanthasamy A, Kanthasamy AG. Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease. Aging. PMID 31454793 DOI: 10.18632/aging.102210  0.632
2019 Kim S, Kwon SH, Kam TI, Panicker N, Karuppagounder SS, Lee S, Lee JH, Kim WR, Kook M, Foss CA, Shen C, Lee H, Kulkarni S, Pasricha PJ, Lee G, et al. Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease. Neuron. PMID 31255487 DOI: 10.1016/J.Neuron.2019.05.035  0.781
2019 Panicker N, Sarkar S, Harischandra DS, Neal M, Kam TI, Jin H, Saminathan H, Langley M, Charli A, Samidurai M, Rokad D, Ghaisas S, Pletnikova O, Dawson VL, Dawson TM, et al. Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia. The Journal of Experimental Medicine. PMID 31036561 DOI: 10.1084/Jem.20182191  0.793
2019 Harischandra DS, Rokad D, Neal ML, Ghaisas S, Manne S, Sarkar S, Panicker N, Zenitsky G, Jin H, Lewis M, Huang X, Anantharam V, Kanthasamy A, Kanthasamy AG. Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein. Science Signaling. 12. PMID 30862700 DOI: 10.1126/Scisignal.Aau4543  0.775
2018 Kam TI, Mao X, Park H, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmachari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, et al. Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson's disease. Science (New York, N.Y.). 362. PMID 30385548 DOI: 10.1126/Science.Aat8407  0.852
2018 Yun SP, Kam TI, Panicker N, Kim S, Oh Y, Park JS, Kwon SH, Park YJ, Karuppagounder SS, Park H, Kim S, Oh N, Kim NA, Lee S, Brahmachari S, et al. Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease. Nature Medicine. PMID 29892066 DOI: 10.1038/S41591-018-0051-5  0.819
2017 Sarkar S, Malovic E, Harishchandra DS, Ghaisas S, Panicker N, Charli A, Palanisamy BN, Rokad D, Jin H, Anantharam V, Kanthasamy A, Kanthasamy AG. Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease. Npj Parkinson's Disease. 3: 30. PMID 29057315 DOI: 10.1038/S41531-017-0032-2  0.803
2017 Panicker N, Dawson VL, Dawson TM. Activation mechanisms of the E3 ubiquitin ligase parkin. The Biochemical Journal. 474: 3075-3086. PMID 28860335 DOI: 10.1042/Bcj20170476  0.692
2017 Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Münch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature. PMID 28099414 DOI: 10.1038/Nature21029  0.564
2016 Mao X, Ou MT, Karuppagounder SS, Kam TI, Yin X, Xiong Y, Ge P, Umanah GE, Brahmachari S, Shin JH, Kang HC, Zhang J, Xu J, Chen R, Park H, ... ... Panicker N, et al. Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3. Science (New York, N.Y.). 353. PMID 27708076 DOI: 10.1126/Science.Aah3374  0.812
2016 Gordon R, Neal ML, Luo J, Langley MR, Harischandra DS, Panicker N, Charli A, Jin H, Anantharam V, Woodruff TM, Zhou QY, Kanthasamy AG, Kanthasamy A. Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration. Nature Communications. 7: 12932. PMID 27703142 DOI: 10.1038/Ncomms12932  0.833
2016 Gordon R, Singh N, Lawana V, Ghosh A, Harischandra DS, Jin H, Hogan C, Sarkar S, Rokad D, Panicker N, Anantharam V, Kanthasamy AG, Kanthasamy A. Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease. Neurobiology of Disease. PMID 27151770 DOI: 10.1016/J.Nbd.2016.04.008  0.821
2015 Panicker N, Saminathan H, Jin H, Neal M, Harischandra DS, Gordon R, Kanthasamy K, Lawana V, Sarkar S, Luo J, Anantharam V, Kanthasamy AG, Kanthasamy A. Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10058-77. PMID 26157004 DOI: 10.1523/Jneurosci.0302-15.2015  0.785
2015 Sarkar S, Panicker N, Neal M, Jin H, Anantharam V, Kanthasamy A, Kanthasamy A. Pesticide-induced Mitochondrial Dysfunction Augments NLRP3 Inflammasome Signaling Pathway in Primary Microglia The Faseb Journal. 29. DOI: 10.1096/Fasebj.29.1_Supplement.777.5  0.81
2014 Jin H, Kanthasamy A, Harischandra DS, Kondru N, Ghosh A, Panicker N, Anantharam V, Rana A, Kanthasamy AG. Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease. The Journal of Biological Chemistry. 289: 34743-67. PMID 25342743 DOI: 10.1074/Jbc.M114.576702  0.767
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