Nikhil Panicker, PhD - Related publications

2009-2016 Biomedical science Iowa State University, Ames, IA, United States 
 2016- Johns Hopkins University School of Medicine, Baltimore, MD, United States 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Guo Y, Ma Z, Ning X, Chen Y, Tian C, Wang X, Zhang Z, Liu J. A Novel Synthetic Precursor of Styryl Sulfone Neuroprotective Agents Inhibits Neuroinflammatory Responses and Oxidative Stress Damage through the P38 Signaling Pathway in the Cell and Animal Model of Parkinson's Disease. Molecules (Basel, Switzerland). 26. PMID 34500807 DOI: 10.3390/molecules26175371   
2021 Chou TW, Chang NP, Krishnagiri M, Patel AP, Lindman M, Angel JP, Kung PL, Atkins C, Daniels BP. Fibrillar α-synuclein induces neurotoxic astrocyte activation via RIP kinase signaling and NF-κB. Cell Death & Disease. 12: 756. PMID 34333522 DOI: 10.1038/s41419-021-04049-0   
2021 Mani S, Sevanan M, Krishnamoorthy A, Sekar S. A systematic review of molecular approaches that link mitochondrial dysfunction and neuroinflammation in Parkinson's disease. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. PMID 34480241 DOI: 10.1007/s10072-021-05551-1   
2021 Zhong Z, Chen W, Gao H, Che N, Xu M, Yang L, Zhang Y, Ye M. Fecal Microbiota Transplantation Exerts a Protective Role in MPTP-Induced Parkinson's Disease via the TLR4/PI3K/AKT/NF-κB Pathway Stimulated by α-Synuclein. Neurochemical Research. PMID 34347266 DOI: 10.1007/s11064-021-03411-0   
2021 Yang X, Zhang Y, Chen Y, He X, Qian Y, Xu S, Gao C, Mo C, Chen S, Xiao Q. LncRNA HOXA-AS2 regulates microglial polarization via recruitment of PRC2 and epigenetic modification of PGC-1α expression. Journal of Neuroinflammation. 18: 197. PMID 34511122 DOI: 10.1186/s12974-021-02267-z   
2021 Kung HC, Lin KJ, Kung CT, Lin TK. Oxidative Stress, Mitochondrial Dysfunction, and Neuroprotection of Polyphenols with Respect to Resveratrol in Parkinson's Disease. Biomedicines. 9. PMID 34440122 DOI: 10.3390/biomedicines9080918   
2021 Lengyel-Zhand Z, Puentes LN, Mach RH. PARkinson's: From cellular mechanisms to potential therapeutics. Pharmacology & Therapeutics. 107968. PMID 34391789 DOI: 10.1016/j.pharmthera.2021.107968   
2021 Burtscher J, Syed MMK, Keller MA, Lashuel HA, Millet GP. Fatal attraction - The role of hypoxia when alpha-synuclein gets intimate with mitochondria. Neurobiology of Aging. 107: 128-141. PMID 34428721 DOI: 10.1016/j.neurobiolaging.2021.07.017   
2021 Li H, Zheng C, Han J, Zhu J, Liu S, Jin T. PD-1/PD-L1 Axis as a Potential Therapeutic Target for Multiple Sclerosis: A T Cell Perspective. Frontiers in Cellular Neuroscience. 15: 716747. PMID 34381337 DOI: 10.3389/fncel.2021.716747   
2021 Bhurtel S, Bok E, Katila N, Kim J, Choi DY. Activation of Nrf2 by methylene blue is associated with the neuroprotection against MPP induced toxicity via ameliorating oxidative stress and mitochondrial dysfunction. Biochemical Pharmacology. 114719. PMID 34352280 DOI: 10.1016/j.bcp.2021.114719   
2021 Guo Q, Wang B, Wang X, Smith WW, Zhu Y, Liu Z. Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models. Cells. 10. PMID 34440619 DOI: 10.3390/cells10081850   
2021 Chen Z, Rasheed M, Deng Y. The epigenetic mechanisms involved in mitochondrial dysfunction: Implication for Parkinson's disease. Brain Pathology (Zurich, Switzerland). e13012. PMID 34414627 DOI: 10.1111/bpa.13012   
2021 Youssef N, Noureldein M, Daoud G, Eid AA. Immune checkpoint inhibitors and diabetes: Mechanisms and predictors. Diabetes & Metabolism. 47: 101193. PMID 33010422 DOI: 10.1016/j.diabet.2020.09.003   
2021 Clarke E, Eriksen JG, Barrett S. The effects of PD-1/PD-L1 checkpoint inhibitors on recurrent/metastatic head and neck squamous cell carcinoma: a critical review of the literature and meta-analysis. Acta Oncologica (Stockholm, Sweden). 1-9. PMID 34410881 DOI: 10.1080/0284186X.2021.1964699   
2021 Wang JF, Wang YP, Xie J, Zhao ZZ, Gupta S, Guo Y, Jia SH, Parodo J, Marshall JC, Deng XM. Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental mouse model of sepsis. Blood. 138: 806-810. PMID 34473230 DOI: 10.1182/blood.2020009417   
2021 Hu X, Lin Z, Wang Z, Zhou Q. Emerging role of PD-L1 modification in cancer immunotherapy. American Journal of Cancer Research. 11: 3832-3840. PMID 34522452   
2021 Ahn EH, Lei K, Kang SS, Wang ZH, Liu X, Hong W, Wang YT, Edgington-Mitchell LE, Jin L, Ye K. Mitochondrial dysfunction triggers the pathogenesis of Parkinson's disease in neuronal C/EBPβ transgenic mice. Molecular Psychiatry. PMID 34489530 DOI: 10.1038/s41380-021-01284-x   
2021 Bai X, Zhang X, Fang R, Wang J, Ma Y, Liu Z, Dong H, Li Q, Ge J, Yu M, Fei J, Sun R, Huang F. Deficiency of leads to accelerated aging and neuroprotection in MPTP-induced Parkinson's disease mice. Aging. 13. PMID 34543233 DOI: 10.18632/aging.203545   
2021 Seo MH, Yeo S. Decrease Associated with Alpha-Synuclein Increase in Muscles of MPTP-Induced Parkinson's Disease Mice. International Journal of Molecular Sciences. 22. PMID 34502283 DOI: 10.3390/ijms22179375   
2021 Wang S, Wen Q, Xiong B, Zhang L, Yu X, Ouyang X. LncRNA NEAT1 knockdown ameliorates MPP-induced cell injury through miR-519a-3p/SP1 axis in Parkinson's disease. World Neurosurgery. PMID 34508910 DOI: 10.1016/j.wneu.2021.08.147   
2021 Ralser DJ, Klümper N, Gevensleben H, Zarbl R, Kaiser C, Landsberg J, Hölzel M, Strieth S, Faridi A, Abramian A, Dietrich D. Molecular and Immune Correlates of PDCD1 (PD-1), PD-L1 (CD274), and PD-L2 (PDCD1LG2) DNA Methylation in Triple Negative Breast Cancer. Journal of Immunotherapy (Hagerstown, Md. : 1997). PMID 34347720 DOI: 10.1097/CJI.0000000000000384   
2021 Kawabata M, Inoue N, Watanabe M, Kobayashi A, Hidaka Y, Miyauchi A, Iwatani Y. gene polymorphisms and thyroid expression of PD-1 ligands differ between Graves' and Hashimoto's diseases. Autoimmunity. 1-10. PMID 34494503 DOI: 10.1080/08916934.2021.1946796   
2021 Henry KE, Mack KN, Nagle VL, Cornejo M, Michel AO, Fox IL, Davydova M, Dilling TR, Pillarsetty N, Lewis JS. ERK Inhibition Improves Anti-PD-L1 Immune Checkpoint Blockade in Preclinical Pancreatic Ductal Adenocarcinoma. Molecular Cancer Therapeutics. PMID 34349003 DOI: 10.1158/1535-7163.MCT-20-1112   
2021 Ahn A, Rodger EJ, Motwani J, Gimenez G, Stockwell PA, Parry M, Hersey P, Chatterjee A, Eccles MR. Transcriptional Reprogramming and Constitutive PD-L1 Expression in Melanoma Are Associated with Dedifferentiation and Activation of Interferon and Tumour Necrosis Factor Signalling Pathways. Cancers. 13. PMID 34503064 DOI: 10.3390/cancers13174250   
2021 Fu Y, Wang D, Wang S, Zhang Q, Liu H, Yang S, Xu Y, Ying B. Blockade of macrophage-associated programmed death 1 inhibits the pyroptosis signalling pathway in sepsis. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. PMID 34382103 DOI: 10.1007/s00011-021-01493-8   
2021 Xiao F, Li C, Lin Y, Peng Z, Xu X, Wen Y, Huang N, Zhang P. Increased risk of periodontitis occurrence in patients with rheumatoid arthritis and its association with the levels of IL-1β and TNF-α in gingival crevicular fluid. Annals of Palliative Medicine. 10: 9078-9087. PMID 34488393 DOI: 10.21037/apm-21-1782   
2021 Shen X, Wang Y, Jin Y, Zheng Q, Shen L, Chen Y, Li Y. PD-L1 expression in non-small cell lung cancer: heterogeneity by pathologic types, tissue sampling and metastasis. Journal of Thoracic Disease. 13: 4360-4370. PMID 34422362 DOI: 10.21037/jtd-21-388   
2021 Zhang H, Wang Z, Hu K, Liu H. Downregulation of long noncoding RNA SNHG7 protects against inflammation and apoptosis in Parkinson's disease model by targeting the miR-425-5p/TRAF5/NF-κB axis. Journal of Biochemical and Molecular Toxicology. e22867. PMID 34369042 DOI: 10.1002/jbt.22867   
2021 Fenner BM, Fenner ME, Prowse N, Hayley SP. LRRK2 and WAVE2 regulate microglial-transition through distinct morphological phenotypes to induce neurotoxicity in a novel two-hit in vitro model of neurodegeneration. Journal of Cellular Physiology. PMID 34543438 DOI: 10.1002/jcp.30588   
2021 van Duijn A, Willemsen KJ, van Uden NOP, Hoyng L, Erades S, Koster J, Luiten RM, Bakker WJ. A secondary role for hypoxia and HIF1 in the regulation of (IFNγ-induced) PD-L1 expression in melanoma. Cancer Immunology, Immunotherapy : Cii. PMID 34268602 DOI: 10.1007/s00262-021-03007-1   
2021 Teng MM, Chen SY, Yang B, Wang Y, Han RY, An MN, Dong YL, You HS. Determining the optimal PD-1/PD-L1 inhibitors for the first-line treatment of non-small-cell lung cancer with high-level PD-L1 expression in China. Cancer Medicine. PMID 34382361 DOI: 10.1002/cam4.4191   
2021 Mao L, Xiao Y, Yang QC, Yang SC, Yang LL, Sun ZJ. TIGIT/CD155 blockade enhances anti-PD-L1 therapy in head and neck squamous cell carcinoma by targeting myeloid-derived suppressor cells. Oral Oncology. 121: 105472. PMID 34333450 DOI: 10.1016/j.oraloncology.2021.105472   
2021 Kawashita S, Aoyagi K, Fukushima K, Hantani R, Naruoka S, Tanimoto A, Hori Y, Toyonaga Y, Yamanaka H, Miyazaki S, Hantani Y. SAR study of small molecule inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction. Chemical Biology & Drug Design. PMID 34495575 DOI: 10.1111/cbdd.13949   
2021 Sutherland TE, Shaw TN, Lennon R, Herrick SE, Rückerl D. Ongoing Exposure to Peritoneal Dialysis Fluid Alters Resident Peritoneal Macrophage Phenotype and Activation Propensity. Frontiers in Immunology. 12: 715209. PMID 34386014 DOI: 10.3389/fimmu.2021.715209   
2021 Quadir H, Hakobyan K, Gaddam M, Ojinnaka U, Ahmed Z, Kannan A, Mostafa JA. Role of Rho-Associated Protein Kinase Inhibition As Therapeutic Strategy for Parkinson's Disease: Dopaminergic Survival and Enhanced Mitophagy. Cureus. 13: e16973. PMID 34377615 DOI: 10.7759/cureus.16973   
2021 O'Connell TJ, Dadafarin S, Jones M, Rodríguez T, Gupta A, Shin E, Moscatello A, Iacob C, Islam H, Tiwari RK, Geliebter J. Androgen Activity Is Associated With PD-L1 Downregulation in Thyroid Cancer. Frontiers in Cell and Developmental Biology. 9: 663130. PMID 34422798 DOI: 10.3389/fcell.2021.663130   
2021 SenGupta T, Palikaras K, Esbensen YQ, Konstantinidis G, Galindo FJN, Achanta K, Kassahun H, Stavgiannoudaki I, Bohr VA, Akbari M, Gaare J, Tzoulis C, Tavernarakis N, Nilsen H. Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology. Cell Reports. 36: 109668. PMID 34496255 DOI: 10.1016/j.celrep.2021.109668   
2021 Ge X, Wang Y, Yu S, Cao X, Chen Y, Cheng Q, Ding F. Anti-inflammatory Activity of a Polypeptide Fraction From in Amyloid β Oligomers Induced Model of Alzheimer's Disease. Frontiers in Pharmacology. 12: 716177. PMID 34456729 DOI: 10.3389/fphar.2021.716177   
2021 Lin Z, Chen C, Yang D, Ding J, Wang G, Ren H. DJ-1 inhibits microglial activation and protects dopaminergic neurons in vitro and in vivo through interacting with microglial p65. Cell Death & Disease. 12: 715. PMID 34274951 DOI: 10.1038/s41419-021-04002-1   
2021 Park JM, Han YM, Hahm KB. Rejuvenation of -Associated Atrophic Gastritis Through Concerted Actions of Placenta-Derived Mesenchymal Stem Cells Prevented Gastric Cancer. Frontiers in Pharmacology. 12: 675443. PMID 34483897 DOI: 10.3389/fphar.2021.675443   
2021 Zhang Y, Chen X, Zheng H, Zhan Y, Luo J, Yang Y, Ning Y, Wang H, Wang W, Fan S. Expression of cancer cell-intrinsic PD-1 associates with PD-L1 and p-S6 and predicts a good prognosis in nasopharyngeal carcinoma. Journal of Cancer. 12: 6118-6125. PMID 34539884 DOI: 10.7150/jca.60739   
2021 Chen Q, Li Y, Zhang W, Yang S, Wang C, Guo Q, Shi W. [Clinical Analysis of Docetaxel Combined with PD-1/PD-L1 Inhibitor in Second-line Treatment of Advanced Non-small Cell Lung Cancer]. Zhongguo Fei Ai Za Zhi = Chinese Journal of Lung Cancer. PMID 34455735 DOI: 10.3779/j.issn.1009-3419.2021.102.26   
2021 Martín-Montañez E, Valverde N, Ladrón de Guevara-Miranda D, Lara E, Romero-Zerbo YS, Millon C, Boraldi F, Ávila-Gámiz F, Pérez-Cano AM, Garrido-Gil P, Labandeira-Garcia JL, Santin LJ, Pavia J, Garcia-Fernandez M. Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease. Redox Biology. 46: 102095. PMID 34418603 DOI: 10.1016/j.redox.2021.102095   
2021 Ding L, Dong HY, Zhou TR, Wang YH, Yan T, Li JC, Wang ZY, Li J, Liang C. PD-1/PD-L1 inhibitors-based treatment for advanced renal cell carcinoma: Mechanisms affecting efficacy and combination therapies. Cancer Medicine. PMID 34382349 DOI: 10.1002/cam4.4190   
2021 Sánchez-Gómez A, Díaz Y, Duarte-Salles T, Compta Y, Martí MJ. Prediabetes, type 2 diabetes mellitus and risk of Parkinson's disease: A population-based cohort study. Parkinsonism & Related Disorders. 89: 22-27. PMID 34216937 DOI: 10.1016/j.parkreldis.2021.06.002   
2021 Mazza MC, Beilina A, Roosen DA, Hauser D, Cookson MR. Generation of iPSC line from a Parkinson patient with PARK7 mutation and CRISPR-edited Gibco human episomal iPSC line to mimic PARK7 mutation. Stem Cell Research. 55: 102506. PMID 34419745 DOI: 10.1016/j.scr.2021.102506   
2021 Lestón Pinilla L, Ugun-Klusek A, Rutella S, De Girolamo LA. Hypoxia Signaling in Parkinson's Disease: There Is Use in Asking "What HIF?" Biology. 10. PMID 34439955 DOI: 10.3390/biology10080723   
2021 Vaccari C, Grotto D, Pereira TDV, de Camargo JLV, Lopes LC. GLP-1 and GIP receptor agonists in the treatment of Parkinson's disease: Translational systematic review and meta-analysis protocol of clinical and preclinical studies. Plos One. 16: e0255726. PMID 34383800 DOI: 10.1371/journal.pone.0255726   
2021 Asanuma M, Miyazaki I. Glutathione and Related Molecules in Parkinsonism. International Journal of Molecular Sciences. 22. PMID 34445395 DOI: 10.3390/ijms22168689   
2021 Hu J, Wu J, Wan F, Kou L, Yin S, Sun Y, Li Y, Zhou Q, Wang T. Calcitriol Alleviates MPP- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson's Disease. Frontiers in Aging Neuroscience. 13: 657095. PMID 34393753 DOI: 10.3389/fnagi.2021.657095