Alan Frazer, Ph.D. - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
pharmacology

118 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 McCoy AM, Prevot TD, Mian MY, Cook JM, Frazer A, Sibille EL, Carreno FR, Lodge DJ. Positive allosteric modulation of α5-GABAA receptors reverses stress-induced alterations in dopamine system function and prepulse inhibition of startle. The International Journal of Neuropsychopharmacology. PMID 35732272 DOI: 10.1093/ijnp/pyac035  0.695
2022 Nagpal AS, Lodge DJ, Potter JS, Frazer A, Tragus R, Curtis ME, Boley AM, Eckmann M. Analgesic Effects of Oxycodone in Combination With Risperidone or Ziprasidone: Results From a Pilot Randomized Controlled Trial in Healthy Volunteers. Frontiers in Pain Research (Lausanne, Switzerland). 3: 752256. PMID 35295795 DOI: 10.3389/fpain.2022.752256  0.494
2020 Bugay V, McCoy AM, Lodge DJ, Brenner R, Frazer A, Carreno FR. Mechanisms associated with the antidepressant-like effects of L-655,708. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32688367 DOI: 10.1038/S41386-020-0772-2  0.722
2020 Carreno FR, Lodge DJ, Frazer A. Ketamine: Leading us into the future for development of antidepressants. Behavioural Brain Research. 383: 112532. PMID 32023492 DOI: 10.1016/J.Bbr.2020.112532  0.596
2017 Carreno FR, Frazer A. Vagal Nerve Stimulation for Treatment-Resistant Depression. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 28585221 DOI: 10.1007/S13311-017-0537-8  0.335
2017 Carreno FR, Collins GT, Frazer A, Lodge DJ. Selective Pharmacological Augmentation of Hippocampal Activity Produces a Sustained Antidepressant-Like Response without Abuse-Related or Psychotomimetic Effects. The International Journal of Neuropsychopharmacology. PMID 28339593 DOI: 10.1093/Ijnp/Pyx003  0.572
2016 Benmansour S, Arroyo LD, Frazer A. Comparison of the Antidepressant-Like Effects of Estradiol and That of Selective Serotonin Reuptake Inhibitors in Middle-Aged Ovariectomized Rats. Frontiers in Aging Neuroscience. 8: 311. PMID 28066235 DOI: 10.3389/Fnagi.2016.00311  0.304
2016 Shah AP, Carreno FR, Wu H, Chung YA, Frazer A. Role of TrkB in the anxiolytic-like and antidepressant-like effects of vagal nerve stimulation: Comparison with desipramine. Neuroscience. PMID 26899129 DOI: 10.1016/J.Neuroscience.2016.02.024  0.357
2016 Frazer A, Carreño F, Collins G, Lodge D. Speaker 4: Alan Frazer, USA. The International Journal of Neuropsychopharmacology. 19: 3-4. DOI: 10.1093/Ijnp/Pyw042.004  0.479
2015 Carreno FR, Donegan JJ, Boley AM, Shah A, DeGuzman M, Frazer A, Lodge DJ. Activation of a ventral hippocampus-medial prefrontal cortex pathway is both necessary and sufficient for an antidepressant response to ketamine. Molecular Psychiatry. PMID 26619811 DOI: 10.1038/Mp.2015.176  0.585
2015 Benmansour S, Adeniji OS, Privratsky AA, Frazer A. Effects of Long-Term Treatment with Estradiol and Estrogenreceptor Subtype Agonists on Serotonergic Function in Ovariectomized Rats. Neuroendocrinology. PMID 26159182 DOI: 10.1159/000437268  0.388
2014 Shah A, Carreno FR, Frazer A. Therapeutic modalities for treatment resistant depression: focus on vagal nerve stimulation and ketamine. Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology. 12: 83-93. PMID 25191499 DOI: 10.9758/Cpn.2014.12.2.83  0.327
2014 Perez SM, Carreno FR, Frazer A, Lodge DJ. Vagal nerve stimulation reverses aberrant dopamine system function in the methylazoxymethanol acetate rodent model of schizophrenia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 9261-7. PMID 25009259 DOI: 10.1523/Jneurosci.0588-14.2014  0.568
2014 Shah A, Frazer A. Influence of acute or chronic administration of ovarian hormones on the effects of desipramine in the forced swim test in female rats. Psychopharmacology. 231: 3685-94. PMID 24590054 DOI: 10.1007/S00213-014-3510-9  0.308
2014 Benmansour S, Privratsky AA, Adeniji OS, Frazer A. Signaling mechanisms involved in the acute effects of estradiol on 5-HT clearance. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 17: 765-77. PMID 24423185 DOI: 10.1017/S146114571300165X  0.385
2014 Carreno FR, Frazer A. Activation of signaling pathways downstream of the brain-derived neurotrophic factor receptor, TrkB, in the rat brain by vagal nerve stimulation and antidepressant drugs. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 17: 247-58. PMID 24103847 DOI: 10.1017/S1461145713000977  0.349
2014 Perez SM, Carreno F, Frazer A, Lodge D. Poster #T184 VAGAL NERVE STIMULATION AS A NOVEL THERAPY FOR THE TREATMENT OF SCHIZOPHRENIA Schizophrenia Research. 153: S354. DOI: 10.1016/S0920-9964(14)71000-X  0.518
2012 Roth MK, Bingham B, Shah A, Joshi A, Frazer A, Strong R, Morilak DA. Effects of chronic plus acute prolonged stress on measures of coping style, anxiety, and evoked HPA-axis reactivity. Neuropharmacology. 63: 1118-26. PMID 22842072 DOI: 10.1016/J.Neuropharm.2012.07.034  0.303
2012 Furmaga H, Carreno FR, Frazer A. Vagal nerve stimulation rapidly activates brain-derived neurotrophic factor receptor TrkB in rat brain. Plos One. 7: e34844. PMID 22563458 DOI: 10.1371/Journal.Pone.0034844  0.327
2012 Furmaga H, Sadhu M, Frazer A. Comparison of ΔFosB immunoreactivity induced by vagal nerve stimulation with that caused by pharmacologically diverse antidepressants. The Journal of Pharmacology and Experimental Therapeutics. 341: 317-25. PMID 22286499 DOI: 10.1124/Jpet.111.188953  0.369
2012 Benmansour S, Weaver RS, Barton AK, Adeniji OS, Frazer A. Comparison of the effects of estradiol and progesterone on serotonergic function. Biological Psychiatry. 71: 633-41. PMID 22225849 DOI: 10.1016/J.Biopsych.2011.11.023  0.433
2011 Furmaga H, Shah A, Frazer A. Serotonergic and noradrenergic pathways are required for the anxiolytic-like and antidepressant-like behavioral effects of repeated vagal nerve stimulation in rats. Biological Psychiatry. 70: 937-45. PMID 21907323 DOI: 10.1016/J.Biopsych.2011.07.020  0.392
2010 Katz MM, Bowden CL, Frazer A. Rethinking depression and the actions of antidepressants: uncovering the links between the neural and behavioral elements. Journal of Affective Disorders. 120: 16-23. PMID 19735945 DOI: 10.1016/J.Jad.2009.08.011  0.312
2009 Benmansour S, Piotrowski JP, Altamirano AV, Frazer A. Impact of ovarian hormones on the modulation of the serotonin transporter by fluvoxamine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 555-64. PMID 18322468 DOI: 10.1038/Npp.2008.23  0.427
2008 Benmansour S, Deltheil T, Piotrowski J, Nicolas L, Reperant C, Gardier AM, Frazer A, David DJ. Influence of brain-derived neurotrophic factor (BDNF) on serotonin neurotransmission in the hippocampus of adult rodents. European Journal of Pharmacology. 587: 90-8. PMID 18474368 DOI: 10.1016/J.Ejphar.2008.03.048  0.383
2008 Cunningham JT, Mifflin SW, Gould GG, Frazer A. Induction of c-Fos and DeltaFosB immunoreactivity in rat brain by Vagal nerve stimulation. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 1884-95. PMID 17957222 DOI: 10.1038/Sj.Npp.1301570  0.323
2008 Bondi CO, Rodriguez G, Gould GG, Frazer A, Morilak DA. Chronic unpredictable stress induces a cognitive deficit and anxiety-like behavior in rats that is prevented by chronic antidepressant drug treatment. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 320-31. PMID 17406647 DOI: 10.1038/Sj.Npp.1301410  0.314
2007 Gould GG, Brooks BW, Frazer A. [(3)H] citalopram binding to serotonin transporter sites in minnow brains. Basic & Clinical Pharmacology & Toxicology. 101: 203-10. PMID 17697042 DOI: 10.1111/J.1742-7843.2007.00100.X  0.38
2007 Price DA, Owens WA, Gould GG, Frazer A, Roberts JL, Daws LC, Giuffrida A. CB1-independent inhibition of dopamine transporter activity by cannabinoids in mouse dorsal striatum. Journal of Neurochemistry. 101: 389-96. PMID 17250681 DOI: 10.1111/J.1471-4159.2006.04383.X  0.617
2007 Gould GG, Javors MA, Frazer A. Effect of chronic administration of duloxetine on serotonin and norepinephrine transporter binding sites in rat brain. Biological Psychiatry. 61: 210-5. PMID 16650830 DOI: 10.1016/J.Biopsych.2006.02.029  0.406
2007 Ordway GA, Schwartz MA, Frazer A. Brain norepinephrine: Neurobiology and therapeutics Brain Norepinephrine: Neurobiology and Therapeutics. 1-642. DOI: 10.1017/CBO9780511544156  0.478
2006 Lu XY, Kim CS, Frazer A, Zhang W. Leptin: a potential novel antidepressant. Proceedings of the National Academy of Sciences of the United States of America. 103: 1593-8. PMID 16423896 DOI: 10.1073/Pnas.0508901103  0.34
2006 Gould GG, Altamirano AV, Javors MA, Frazer A. A comparison of the chronic treatment effects of venlafaxine and other antidepressants on serotonin and norepinephrine transporters. Biological Psychiatry. 59: 408-14. PMID 16140280 DOI: 10.1016/J.Biopsych.2005.07.011  0.391
2005 Daws LC, Montañez S, Owens WA, Gould GG, Frazer A, Toney GM, Gerhardt GA. Transport mechanisms governing serotonin clearance in vivo revealed by high-speed chronoamperometry. Journal of Neuroscience Methods. 143: 49-62. PMID 15763136 DOI: 10.1016/J.Jneumeth.2004.09.011  0.641
2004 Katz MM, Houston JP, Brannan S, Bowden CL, Berman N, Swann AC, Frazer A. A multivantaged behavioural method for measuring onset and sequence of the clinical actions of antidepressants. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 7: 471-9. PMID 15154974 DOI: 10.1017/S1461145704004407  0.302
2004 Benmansour S, Altamirano AV, Jones DJ, Sanchez TA, Gould GG, Pardon MC, Morilak DA, Frazer A. Regulation of the norepinephrine transporter by chronic administration of antidepressants. Biological Psychiatry. 55: 313-6. PMID 14744474 DOI: 10.1016/S0006-3223(03)00676-0  0.401
2004 Katz MM, Tekell JL, Bowden CL, Brannan S, Houston JP, Berman N, Frazer A. Onset and early behavioral effects of pharmacologically different antidepressants and placebo in depression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 566-79. PMID 14627997 DOI: 10.1038/Sj.Npp.1300341  0.314
2003 Montañez S, Daws LC, Gould GG, Frazer A. Serotonin (5-HT) transporter (SERT) function after graded destruction of serotonergic neurons. Journal of Neurochemistry. 87: 861-7. PMID 14622117 DOI: 10.1046/J.1471-4159.2003.02032.X  0.66
2003 Gould GG, Mehta AK, Frazer A, Ticku MK. Quantitative autoradiographic analysis of the new radioligand [(3)H](2E)-(5-hydroxy-5,7,8,9-tetrahydro-6H-benzo[a][7]annulen-6-ylidene) ethanoic acid ([(3)H]NCS-382) at gamma-hydroxybutyric acid (GHB) binding sites in rat brain. Brain Research. 979: 51-6. PMID 12850570 DOI: 10.1016/S0006-8993(03)02865-8  0.327
2003 Gould GG, Pardon MC, Morilak DA, Frazer A. Regulatory effects of reboxetine treatment alone, or following paroxetine treatment, on brain noradrenergic and serotonergic systems. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1633-41. PMID 12825093 DOI: 10.1038/Sj.Npp.1300236  0.38
2003 Galici R, Galli A, Jones DJ, Sanchez TA, Saunders C, Frazer A, Gould GG, Lin RZ, France CP. Selective decreases in amphetamine self-administration and regulation of dopamine transporter function in diabetic rats. Neuroendocrinology. 77: 132-40. PMID 12624535 DOI: 10.1159/000068650  0.342
2002 Montañez S, Daws LC, Gould GG, Gerhardt GA, Frazer A. Differential in vivo clearance of serotonin in rat dorsal raphe nucleus and CA3 region. Brain Research. 955: 236-44. PMID 12419542 DOI: 10.1016/S0006-8993(02)03470-4  0.644
2002 Benmansour S, Owens WA, Cecchi M, Morilak DA, Frazer A. Serotonin clearance in vivo is altered to a greater extent by antidepressant-induced downregulation of the serotonin transporter than by acute blockade of this transporter. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6766-72. PMID 12151556 DOI: 10.1523/Jneurosci.22-15-06766.2002  0.406
2002 Frazer A, Benmansour S. Delayed pharmacological effects of antidepressants. Molecular Psychiatry. 7: S23-8. PMID 11986992 DOI: 10.1038/Sj.Mp.4001015  0.397
2001 Clarke WP, Berg KA, Gould G, Frazer A. Characterization of 5-HT(₁A,B) and 5-HT(â‚‚A,C) serotonin receptor binding. Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. Unit1.23. PMID 21959751 DOI: 10.1002/0471141755.Ph0123S12  0.384
2000 Javors MA, Houston JP, Tekell JL, Brannan SK, Frazer A. Reduction of platelet serotonin content in depressed patients treated with either paroxetine or desipramine. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 3: 229-235. PMID 11343600 DOI: 10.1017/S146114570000198X  0.372
2000 Daws LC, Gould GG, Teicher SD, Gerhardt GA, Frazer A. 5-HT(1B) receptor-mediated regulation of serotonin clearance in rat hippocampus in vivo. Journal of Neurochemistry. 75: 2113-22. PMID 11032901 DOI: 10.1046/J.1471-4159.2000.0752113.X  0.643
1999 Frazer A, Gerhardt GA, Daws LC. New views of biogenic amine transporter function: implications for neuropsychopharmacology. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 2: 305-320. PMID 11285147 DOI: 10.1017/S1461145799001625  0.624
1999 Benmansour S, Cecchi M, Morilak DA, Gerhardt GA, Javors MA, Gould GG, Frazer A. Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10494-501. PMID 10575045 DOI: 10.1523/Jneurosci.19-23-10494.1999  0.432
1999 Daws LC, Gerhardt GA, Frazer A. 5-HT1B antagonists modulate clearance of extracellular serotonin in rat hippocampus. Neuroscience Letters. 266: 165-8. PMID 10465699 DOI: 10.1016/S0304-3940(99)00277-3  0.657
1998 Frazer A, Daws LC. Serotonin transporter function in vivo: assessment by chronoamperometry. Annals of the New York Academy of Sciences. 861: 217-29. PMID 9928259 DOI: 10.1111/J.1749-6632.1998.Tb10193.X  0.649
1998 Daws LC, Lopez R, Frazer A. Effects of antidepressant treatment on inhibitory avoidance behavior and amygdaloid beta-adrenoceptors in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 19: 300-13. PMID 9718593 DOI: 10.1016/S0893-133X(98)00016-5  0.705
1998 Daws LC, Toney GM, Gerhardt GA, Frazer A. In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters. The Journal of Pharmacology and Experimental Therapeutics. 286: 967-76. PMID 9694957  0.623
1997 Schweizer E, Thielen RJ, Frazer A. Venlafaxine:a novel antidepressant compound. Expert Opinion On Investigational Drugs. 6: 65-78. PMID 15989562 DOI: 10.1517/13543784.6.1.65  0.378
1997 Daws LC, Toney GM, Davis DJ, Gerhardt GA, Frazer A. In vivo chronoamperometric measurements of the clearance of exogenously applied serotonin in the rat dentate gyrus. Journal of Neuroscience Methods. 78: 139-50. PMID 9497010 DOI: 10.1016/S0165-0270(97)00144-1  0.648
1997 Frazer A. Pharmacology of antidepressants. Journal of Clinical Psychopharmacology. 17: 2S-18S. PMID 9090573 DOI: 10.1097/00004714-199704001-00002  0.329
1994 Hensler JG, Ferry RC, Labow DM, Kovachich GB, Frazer A. Quantitative autoradiography of the serotonin transporter to assess the distribution of serotonergic projections from the dorsal raphe nucleus. Synapse (New York, N.Y.). 17: 1-15. PMID 8042142 DOI: 10.1002/Syn.890170102  0.681
1994 Katz MM, Maas JW, Frazer A, Koslow SH, Bowden CL, Berman N, Swann AC, Stokes PE. Drug-induced actions on brain neurotransmitter systems and changes in the behaviors and emotions of depressed patients. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 11: 89-100. PMID 7530963 DOI: 10.1038/Npp.1994.38  0.347
1993 Chamberlain J, Offord SJ, Wolfe BB, Tyau LS, Wang HL, Frazer A. Potency of 5-hydroxytryptamine1a agonists to inhibit adenylyl cyclase activity is a function of affinity for the "low-affinity" state of [3H]8-hydroxy-N,N-dipropylaminotetralin ([3H]8-OH-DPAT) binding. The Journal of Pharmacology and Experimental Therapeutics. 266: 618-25. PMID 8355195  0.696
1993 Kovachich GB, Frazer A, Aronson CE. Effect of chronic administration of antidepressants on alpha 2-adrenoceptors in the locus coeruleus and its projection fields in rat brain determined by quantitative autoradiography. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 8: 57-65. PMID 8093834 DOI: 10.1038/Npp.1993.7  0.358
1992 Chumpradit S, Kung MP, Panyachotipun C, Prapansiri V, Foulon C, Brooks BP, Szabo SA, Tejani-Butt S, Frazer A, Kung HF. Iodinated tomoxetine derivatives as selective ligands for serotonin and norepinephrine uptake sites. Journal of Medicinal Chemistry. 35: 4492-7. PMID 1447750 DOI: 10.1021/Jm00101A029  0.307
1991 Hensler JG, Kovachich GB, Frazer A. A quantitative autoradiographic study of serotonin1A receptor regulation. Effect of 5,7-dihydroxytryptamine and antidepressant treatments. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 4: 131-44. PMID 2025379  0.688
1991 Katz MM, Koslow SH, Maas JW, Frazer A, Kocsis J, Secunda S, Bowden CL, Casper RC. Identifying the specific clinical actions of amitriptyline: interrelationships of behaviour, affect and plasma levels in depression. Psychological Medicine. 21: 599-611. PMID 1946849 DOI: 10.1017/S0033291700022236  0.318
1991 Hensler JG, Ordway GA, Gambarana C, Areso P, Frazer A. Serotonergic neurons do not influence the regulation of beta adrenoceptors induced by either desipramine or isoproterenol. The Journal of Pharmacology and Experimental Therapeutics. 256: 656-64. PMID 1847207  0.72
1991 Areso MP, Frazer A. Effect of repeated administration of novel stressors on central beta adrenoceptors. Journal of Neural Transmission. General Section. 86: 229-35. PMID 1685653 DOI: 10.1007/Bf01250709  0.343
1991 Poland RE, Frazer A. Corticosterone and prolactin response to TFMPP in rats during repeated antidepressant administration. The Journal of Pharmacy and Pharmacology. 43: 54-6. PMID 1676062 DOI: 10.1111/J.2042-7158.1991.Tb05450.X  0.379
1991 Ordway GA, Gambarana C, Tejani-Butt SM, Areso P, Hauptmann M, Frazer A. Preferential reduction of binding of 125I-iodopindolol to beta-1 adrenoceptors in the amygdala of rat after antidepressant treatments. The Journal of Pharmacology and Experimental Therapeutics. 257: 681-90. PMID 1674532  0.604
1991 Gambarana C, Ordway GA, Hauptmann M, Tejani-Butt S, Frazer A. Central administration of 1-isoproterenol in vivo induces a preferential regulation of beta 2-adrenoceptors in the central nervous system of the rat. Brain Research. 555: 141-8. PMID 1657295 DOI: 10.1016/0006-8993(91)90870-2  0.602
1990 Frazer A, Maayani S, Wolfe BB. Subtypes of receptors for serotonin. Annual Review of Pharmacology and Toxicology. 30: 307-48. PMID 2188571 DOI: 10.1146/Annurev.Pa.30.040190.001515  0.372
1990 Frazer A, Hensler JG. 5-HT1A receptors and 5-HT1A-mediated responses: effect of treatments that modify serotonergic neurotransmission. Annals of the New York Academy of Sciences. 600: 460-74; discussion 4. PMID 2174665 DOI: 10.1111/J.1749-6632.1990.Tb16902.X  0.666
1990 Tejani-Butt SM, Brunswick DJ, Frazer A. [3H]nisoxetine: a new radioligand for norepinephrine uptake sites in brain. European Journal of Pharmacology. 191: 239-43. PMID 2086242 DOI: 10.1016/0014-2999(90)94155-Q  0.339
1989 Lucki I, Ward HR, Frazer A. Effect of 1-(m-chlorophenyl)piperazine and 1-(m-trifluoromethylphenyl)piperazine on locomotor activity. The Journal of Pharmacology and Experimental Therapeutics. 249: 155-64. PMID 2709329  0.551
1989 Bauer MS, Poland RE, Whybrow PC, Frazer A. Pituitary-adrenal and thyroid effects on melatonin content of the rat pineal gland. Psychoneuroendocrinology. 14: 165-75. PMID 2547223 DOI: 10.1016/0306-4530(89)90014-0  0.327
1988 Offord SJ, Ordway GA, Frazer A. Application of [125I]iodocyanopindolol to measure 5-hydroxytryptamine1B receptors in the brain of the rat. The Journal of Pharmacology and Experimental Therapeutics. 244: 144-53. PMID 3335996  0.779
1988 Tejani-Butt SM, Hauptmann M, D'Mello A, Frazer A, Marcoccia JM, Brunswick DJ. Evaluation of mono- and dibenzoyl esters of dopamine as potential pro-drugs for dopamine in the central nervous system. Naunyn-Schmiedeberg's Archives of Pharmacology. 338: 497-503. PMID 3244391 DOI: 10.1007/Bf00179320  0.303
1988 Kovachich GB, Aronson CE, Brunswick DJ, Frazer A. Quantitative autoradiography of serotonin uptake sites in rat brain using [3H]cyanoimipramine. Brain Research. 454: 78-88. PMID 2970277 DOI: 10.1016/0006-8993(88)90805-0  0.377
1988 Ordway GA, Gambarana C, Frazer A. Quantitative autoradiography of central beta adrenoceptor subtypes: comparison of the effects of chronic treatment with desipramine or centrally administered l-isoproterenol. The Journal of Pharmacology and Experimental Therapeutics. 247: 379-89. PMID 2845059  0.57
1988 Ordway GA, Frazer A. Effects of prenalterol on beta adrenergic responsiveness and receptors in the cerebral cortex of the rat. Neuropharmacology. 27: 529-36. PMID 2839793 DOI: 10.1016/0028-3908(88)90136-0  0.611
1987 Ordway GA, O'Donnell JM, Frazer A. Effects of clenbuterol on central beta-1 and beta-2 adrenergic receptors of the rat. The Journal of Pharmacology and Experimental Therapeutics. 241: 187-95. PMID 3033200  0.653
1986 Frazer A, Ordway G, O'Donnell J, Vos P, Wolfe B. Effect of repeated administration of clenbuterol on the regulation of beta-adrenoceptors in the central nervous system of the rat. Ciba Foundation Symposium. 123: 170-90. PMID 3028723  0.557
1985 Sills MA, Lucki I, Frazer A. Development of selective tolerance to the serotonin behavioral syndrome and suppression of locomotor activity after repeated administration of either 5-MeODMT or mCPP. Life Sciences. 36: 2463-9. PMID 4010463 DOI: 10.1016/0024-3205(85)90142-0  0.718
1985 Lucki I, Frazer A. Performance and extinction of lever press behavior following chronic administration of desipramine to rats. Psychopharmacology. 85: 253-9. PMID 3923511 DOI: 10.1007/Bf00428183  0.549
1985 O'Donnell JM, Frazer A. Effects of clenbuterol and antidepressant drugs on beta adrenergic receptor/N-protein coupling in the cerebral cortex of the rat. The Journal of Pharmacology and Experimental Therapeutics. 234: 30-6. PMID 2989510  0.516
1985 Frazer A, Lucki I, Sills M. Alterations in monoamine-containing neuronal function due to administration of antidepressants repeatedly to rats. Acta Pharmacologica Et Toxicologica. 56: 21-34. PMID 2984890 DOI: 10.1111/J.1600-0773.1985.Tb02496.X  0.71
1984 Sills MA, Wolfe BB, Frazer A. Multiple states of the 5-hydroxytryptamine1 receptor as indicated by the effects of GTP on [3H]5-hydroxytryptamine binding in rat frontal cortex. Molecular Pharmacology. 26: 10-8. PMID 6749126  0.648
1984 Lucki I, Nobler MS, Frazer A. Differential actions of serotonin antagonists on two behavioral models of serotonin receptor activation in the rat. The Journal of Pharmacology and Experimental Therapeutics. 228: 133-9. PMID 6694097  0.548
1984 Sills MA, Wolfe BB, Frazer A. Determination of selective and nonselective compounds for the 5-HT 1A and 5-HT 1B receptor subtypes in rat frontal cortex. The Journal of Pharmacology and Experimental Therapeutics. 231: 480-7. PMID 6502510  0.648
1984 O'Donnell JM, Wolfe BB, Frazer A. Agonist interactions with beta adrenergic receptors in rat brain. The Journal of Pharmacology and Experimental Therapeutics. 228: 640-7. PMID 6142940  0.514
1984 Frazer A, Conway P. Pharmacologic mechanisms of action of antidepressants. The Psychiatric Clinics of North America. 7: 575-86. PMID 6091070 DOI: 10.1016/S0193-953X(18)30751-2  0.322
1984 Frazer A, OʼDonnell J, Tondo L, Conway P, Gottlieb J, Brunswick D. NEW APPROACHES TO THE STUDY OF DRUG EFFECTS ON CENTRAL BETA-ADRENERGIC RECEPTORS Clinical Neuropharmacology. 7: S162. DOI: 10.1097/00002826-198406001-00151  0.322
1983 Heydorn WE, Lucki I, Frazer A. Continuous light paradoxically reduces catecholamine-induced melatonin production. Brain Research. 267: 175-8. PMID 6860943 DOI: 10.1016/0006-8993(83)91054-5  0.706
1983 Gerber JC, Choki J, Brunswick DJ, Reivich M, Frazer A. The effect of antidepressant drugs on regional cerebral glucose utilization in the rat. Brain Research. 269: 319-25. PMID 6309323 DOI: 10.1016/0006-8993(83)90142-7  0.333
1983 Frazer A, Lucki I. Is the“new” more useful than the“old”? Behavioral and Brain Sciences. 6: 554-555. DOI: 10.1017/S0140525X00017404  0.469
1982 Lucki I, Frazer A. Prevention of the serotonin syndrome in rats by repeated administration of monoamine oxidase inhibitors but not tricyclic antidepressants. Psychopharmacology. 77: 205-11. PMID 6812141 DOI: 10.1007/Bf00464567  0.624
1982 Heydorn WE, Brunswick DJ, Frazer A. Effect of treatment of rats with antidepressants on melatonin concentrations in the pineal gland and serum. The Journal of Pharmacology and Experimental Therapeutics. 222: 534-43. PMID 6286922  0.676
1982 Frazer A, Lucki I. Antidepressant drugs: effects on beta-adrenergic and serotonineregic receptors. Advances in Biochemical Psychopharmacology. 31: 69-90. PMID 6282067  0.519
1982 Weiss B, Heydorn W, Frazer A. Modulation of the beta-adrenergic receptor-adenylate cyclase system following acute and repeated treatment with antidepressants. Advances in Biochemical Psychopharmacology. 31: 37-53. PMID 6282063  0.645
1981 Heydorn WE, Frazer A, Weiss B. Electrical stimulation of sympathetic nerves increases the concentration of cyclic AMP in rat pineal gland. Proceedings of the National Academy of Sciences of the United States of America. 78: 7176-9. PMID 6273917 DOI: 10.1073/Pnas.78.11.7176  0.666
1981 Moyer JA, Greenberg LH, Frazer A, Weiss B. Subsensitivity of the beta-adrenergic receptor-linked adenylate cyclase system of rat pineal gland following repeated treatment with desmethylimipramine and nialamide. Molecular Pharmacology. 19: 187-93. PMID 6262613  0.638
1980 Savage DD, Mendels J, Frazer A. Decrease in [3H]-serotonin binding in rat brain produced by the repeated administration of either monoamine oxidase inhibitors or centrally acting serotonin agonists. Neuropharmacology. 19: 1063-70. PMID 7442938 DOI: 10.1016/0028-3908(80)90102-1  0.638
1980 Savage DD, Mendels J, Frazer A. Monoamine oxidase inhibitors and serotonin uptake inhibitors: differential effects on [3H]serotonin binding sites in rat brain. The Journal of Pharmacology and Experimental Therapeutics. 212: 259-63. PMID 7351637  0.573
1980 Heydorn WE, Mendels J, Frazer A. Effects of darkness and of desmethylimipramine on pineal gland concentrations of adenosine 3', 5'-monophosphate. Biochemical Pharmacology. 29: 1341-6. PMID 6249312 DOI: 10.1016/0006-2952(80)90428-1  0.679
1980 Sellinger-Barnette MM, Mendels J, Frazer A. The effect of psychoactive drugs on beta-adrenergic receptor binding sites in rat brain. Neuropharmacology. 19: 447-54. PMID 6248811 DOI: 10.1016/0028-3908(80)90052-0  0.414
1980 Heydorn W, Frazer A, Mendels J. Do tricyclic antidepressants enhance adrenergic transmission? An update. The American Journal of Psychiatry. 137: 113-4. PMID 6243449 DOI: 10.1176/Ajp.137.1.113  0.649
1980 Hess ME, Reynolds KA, Frazer A, Viscusi D. Inhibitory effects of desmethylimipramine on the action of thyroxine on cardiac beta-receptors and myocardial phosphorylase. Journal of Cardiovascular Pharmacology. 2: 867-79. PMID 6160335 DOI: 10.1097/00005344-198011000-00015  0.577
1979 Savage DD, Frazer A, Mendels J. Differential effects of monoamine oxidase inhibitors and serotonin reuptake inhibitors on 3H-serotonin receptor binding in rat brain. European Journal of Pharmacology. 58: 87-8. PMID 315323 DOI: 10.1016/0014-2999(79)90344-3  0.623
1979 Moyer JA, Greenberg LH, Frazer A, Brunswick DJ, Mendels J, Weiss B. Opposite effects of acute and repeated administration of desmethylimipramine on adrenergic responsiveness in rat pineal gland. Life Sciences. 24: 2237-44. PMID 228145 DOI: 10.1016/0024-3205(79)90100-0  0.675
1978 Sarai K, Frazer A, Brunswick D, Mendels J. Desmethylimipramine-induced decrease in beta-adrenergic receptor binding in rat cerebral cortex. Biochemical Pharmacology. 27: 2179-81. PMID 215151 DOI: 10.1016/0006-2952(78)90293-9  0.386
1978 Frazer A, Hess ME, Mendels J, Gable B, Kunkel E, Bender A. Influence of acute and chronic treatment with desmethylimipramine on catecholamine effects in the rat. The Journal of Pharmacology and Experimental Therapeutics. 206: 311-9. PMID 210273  0.511
1977 Frazer A, Mendels J. Do tricyclic antidepressants enhance adrenergic transmission? The American Journal of Psychiatry. 134: 1040-2. PMID 197853 DOI: 10.1176/Ajp.134.9.1040  0.313
1974 Frazer A, Pandey G, Mendels J, Neeley S, Kane M, Hess ME. The effect of tri-iodothyronine in combination with impramine on [3H]-cyclic AMP production in slices of rat cerebral cortex. Neuropharmacology. 13: 1311-40. PMID 4376223  0.509
1974 Wang YC, Pandey GN, Mendels J, Frazer A. Platelet adenylate cyclase responses in depression: implications for a receptor defect. Psychopharmacologia. 36: 291-300. PMID 4367922 DOI: 10.1007/Bf00422561  0.314
1974 Mendels J, Frazer A. Brain biogenic amine depletion and mood. Archives of General Psychiatry. 30: 447-51. PMID 4273761 DOI: 10.1001/Archpsyc.1974.01760100019004  0.316
1974 Frazer A, Pandey G, Mendels J, Neeley S, Kane M, Hess ME. The effect of tri-iodothyronine in combination with imipramine on [3H]-cyclic AMP production in slices of rat cerebral cortex Neuropharmacology. 13: 1131-1140. DOI: 10.1016/0028-3908(74)90063-X  0.543
1974 Frazer A, Pandey G, Wang Y, Hess M, Mendels J. Adrenergic receptor function in depression Journal of Psychiatric Research. 10: 319. DOI: 10.1016/0022-3956(74)90019-3  0.555
1969 Frazer A, Hess ME. Parasympathetic responses in hyperthyroid rats. The Journal of Pharmacology and Experimental Therapeutics. 170: 1-9. PMID 5351003  0.504
1969 Frazer A, Hess ME, Shanfeld J. The effects of thyroxine on rat heart adenosine 3',5'-monophosphate, phosphorylase b kinase and phosphorylase a activity. The Journal of Pharmacology and Experimental Therapeutics. 170: 10-6. PMID 4390812  0.486
1969 Shanfeld J, Frazer A, Hess ME. Dissociation of the increased formation of cardiac adenosine 3',5'-monophosphate from the positive inotropic effect of norepinephrine. The Journal of Pharmacology and Experimental Therapeutics. 169: 315-20. PMID 4309999  0.451
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