Alan Frazer, Ph.D. - Related publications

University of Pennsylvania, Philadelphia, PA, United States 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Tabuchi H, Kitamura Y, Ushio S, Kan S, Wada Y, Sumiyoshi Y, Izushi Y, Miyazaki I, Asanuma M, Sendo T. Influence of 5-HT receptor function on anxiety-like behavior induced by a combination treatment with doxorubicin and cyclophosphamide in rats. Psychopharmacology. PMID 34557945 DOI: 10.1007/s00213-021-05979-5   
2021 Gu J, Hou Z, Zhou X, Wang Q, Chen Y, Zhang J. Activation of 5-HT receptor in Lateral Habenula impaired contextual fear memory and hippocampal LTP in rat. Neuroscience Letters. 136305. PMID 34699942 DOI: 10.1016/j.neulet.2021.136305   
2021 Becker G, Da Silva S, Sabo AN, Antal MC, Kemmel V, Monassier L. Blood-Brain Barrier Permeability: Is 5-Hydroxytryptamine Receptor Type 4 a Game Changer? Pharmaceutics. 13. PMID 34834271 DOI: 10.3390/pharmaceutics13111856   
2021 Kułaga D, Drabczyk AK, Satała G, Latacz G, Rózga K, Plażuk D, Jaśkowska J. Design and synthesis of new potent 5-HT receptor ligands as a candidate for the treatment of central nervous system diseases. European Journal of Medicinal Chemistry. 227: 113931. PMID 34710746 DOI: 10.1016/j.ejmech.2021.113931   
2021 Shi M, Tang J, Yang C, Guo G, Ou H, Chen W. Pimavanserin, a 5-hydroxytryptamine 2A receptor inverse agonist, reverses prepulse inhibition deficits in the nucleus accumbens and ventral hippocampus. Neuropharmacology. 201: 108838. PMID 34666074 DOI: 10.1016/j.neuropharm.2021.108838   
2021 Tarbit E, Singh I, Peart JN, Bivol S, Rose'Meyer RB. Increased release of serotonin from rat primary isolated adult cardiac myofibroblasts. Scientific Reports. 11: 20376. PMID 34645867 DOI: 10.1038/s41598-021-99632-y   
2021 Zhang YM, Ye LY, Li TY, Guo F, Guo F, Li Y, Li YF. New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism. Acta Pharmacologica Sinica. PMID 34811511 DOI: 10.1038/s41401-021-00807-0   
2021 Reddy GS, Kamaraj R, Hossain KA, Kumar JS, Thirupataiah B, Medishetti R, Sushma Sri N, Misra P, Pal M. Amberlyst-15 catalysed synthesis of novel indole derivatives under ultrasound irradiation: Their evaluation as serotonin 5-HT receptor agonists. Bioorganic Chemistry. 116: 105380. PMID 34670330 DOI: 10.1016/j.bioorg.2021.105380   
2021 Lee BH, Hille B, Koh DS. Serotonin modulates melatonin synthesis as an autocrine neurotransmitter in the pineal gland. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34675083 DOI: 10.1073/pnas.2113852118   
2021 Ling S, Ceban F, Lui LMW, Lee Y, Teopiz KM, Rodrigues NB, Lipsitz O, Gill H, Subramaniapillai M, Mansur RB, Lin K, Ho R, Rosenblat JD, Castle D, McIntyre RS. Molecular Mechanisms of Psilocybin and Implications for the Treatment of Depression. Cns Drugs. PMID 34791625 DOI: 10.1007/s40263-021-00877-y   
2021 de Cates AN, Wright LC, Martens MAG, Gibson D, Türkmen C, Filippini N, Cowen PJ, Harmer CJ, Murphy SE. Déjà-vu? Neural and behavioural effects of the 5-HT receptor agonist, prucalopride, in a hippocampal-dependent memory task. Translational Psychiatry. 11: 497. PMID 34602607 DOI: 10.1038/s41398-021-01568-4   
2021 Tupal S, Faingold CL. Serotonin 5-HT receptors play a critical role in the action of fenfluramine to block seizure-induced sudden death in a mouse model of SUDEP. Epilepsy Research. 177: 106777. PMID 34601387 DOI: 10.1016/j.eplepsyres.2021.106777   
2021 Solas M, Van Dam D, Janssens J, Ocariz U, Vermeiren Y, De Deyn PP, Ramirez MJ. 5-HT receptors in Alzheimer's disease. Neurochemistry International. 150: 105185. PMID 34555475 DOI: 10.1016/j.neuint.2021.105185   
2021 Zhuang J, Xu F. Systemic 8-OH-DPAT Challenge Causes Hyperventilation Largely via Activating pre-Botzinger Complex 5-HT Receptors. Respiratory Physiology & Neurobiology. 103810. PMID 34728431 DOI: 10.1016/j.resp.2021.103810   
2021 Fierro A, Matthies DJ, Cassels BK, Jaque P, Zapata-Torres G. 5-HT Receptor Subfamily and the Halogen Bond Promise. Journal of Chemical Information and Modeling. 61: 5001-5012. PMID 34617740 DOI: 10.1021/acs.jcim.1c00466   
2021 Camicia F, Vaca HR, Park SK, Bivona AE, Naidich A, Preza M, Koziol U, Celentano AM, Marchant JS, Rosenzvit MC. Characterization of a new type of neuronal 5-HT G- protein coupled receptor in the cestode nervous system. Plos One. 16: e0259104. PMID 34762657 DOI: 10.1371/journal.pone.0259104   
2021 Yu B, Battaglia DM, Foster TP, Nichols CD. Serotonin 5-HT receptor activity mediates adipocyte differentiation through control of adipogenic gene expression. Scientific Reports. 11: 19714. PMID 34611182 DOI: 10.1038/s41598-021-98970-1   
2021 Shinde AK, Badange RK, Reballi V, Achanta PK, Bojja K, Manchineella S, Rao Muddana N, Subramanian R, Choudary Palacharla R, Benade V, Jayarajan P, Thentu JB, Lingavarapu BB, Yarra S, Kagita N, et al. 1-[2-(1-Cyclobutylpiperidin-4-yloxy)-6,7-dihydro-4H-thiazolo[5,4-c]pyridin-5-yl]propan-1-one: a Histamine H Receptor Inverse Agonist with Efficacy in Animal Models of Cognition. Chemmedchem. PMID 34761873 DOI: 10.1002/cmdc.202100583   
2021 Chaudhary P, Guragain D, Chang JH, Kim JA. TPH1 and 5-HT Receptor Overexpression Leading to Gemcitabine-Resistance Requires Non-Canonical Permissive Action of EZH2 in Pancreatic Ductal Adenocarcinoma. Cancers. 13. PMID 34771469 DOI: 10.3390/cancers13215305   
2021 Yan W, Fan L, Yu J, Liu R, Wang H, Tan L, Wang S, Cheng J. 2-Phenylcyclopropylmethylamine Derivatives as Dopamine D Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation. Journal of Medicinal Chemistry. PMID 34797051 DOI: 10.1021/acs.jmedchem.1c01327   
2021 Alemán-Jiménez C, Domínguez-Perles R, Gallego-Gómez JI, Simonelli-Muñoz A, Moine E, Durand T, Crauste C, Ferreres F, Gil-Izquierdo Á, Medina S. Fatty Acid Hydroxytyrosyl Esters of Olive Oils Are Bioaccessible According to Simulated Gastrointestinal Digestion: Unraveling the Role of Digestive Enzymes on Their Stability. Journal of Agricultural and Food Chemistry. PMID 34797062 DOI: 10.1021/acs.jafc.1c05373   
2021 De Luca R, Volpe C, Mistretta O, Paci R, Ferrera G, Caputo V, Rosati G, Cicero G. NEPA (netupitant/palonosetron) for the antiemetic prophylaxis of nausea and vomiting induced by chemotherapy (CINV) with Folfirinox and Folfoxiri even during the COVID-19 pandemic: a real-life study. European Review For Medical and Pharmacological Sciences. 25: 5310-5317. PMID 34486707 DOI: 10.26355/eurrev_202108_26552   
2021 Gu P, Chen C, Wu Q, Dong C, Wang T, Wan Q, Dong X. The Effect and Safety of 5-HT Receptor Agonist Lasmiditan on Migraine: A Systematic Review and Meta-Analysis. Biomed Research International. 2021: 6663591. PMID 34660796 DOI: 10.1155/2021/6663591   
2021 Yang L, Jin H. Effect of Heat Treatment on the Physic-Mechanical Characteristics of S.T. Blake. Materials (Basel, Switzerland). 14. PMID 34772175 DOI: 10.3390/ma14216643   
2021 Piechotta V, Adams A, Haque M, Scheckel B, Kreuzberger N, Monsef I, Jordan K, Kuhr K, Skoetz N. Antiemetics for adults for prevention of nausea and vomiting caused by moderately or highly emetogenic chemotherapy: a network meta-analysis. The Cochrane Database of Systematic Reviews. 11: CD012775. PMID 34784425 DOI: 10.1002/14651858.CD012775.pub2   
2021 Jian X, Liang P, Wang K, Jia J, Wang X. Serotonin 1A receptor agonist modulation of motor deficits and cortical oscillations by NMDA receptor interaction in parkinsonian rats. Neuropharmacology. 108881. PMID 34785162 DOI: 10.1016/j.neuropharm.2021.108881   
2021 Fouad Shalaby MA, Abd El Latif HA, El Yamani M, Galal MA, Kamal S, Sindi I, Masaood R. Therapeutic activity of sarpogrelate and dopamine D receptor agonists on cardiovascular and renal systems in rats with alloxan-induced diabetes. Bmc Pharmacology & Toxicology. 22: 64. PMID 34702339 DOI: 10.1186/s40360-021-00526-6   
2021 Yeker RM, Shaffer AD, Viswanathan P, Witchel SF, Mollen K, Yip L, Monaco SE, Duvvuri U, Simons JP. Chronic Lymphocytic Thyroiditis and Aggressiveness of Pediatric Differentiated Thyroid Cancer. The Laryngoscope. PMID 34687456 DOI: 10.1002/lary.29908   
2021 Islam MR, Teleb M, Karageorgos V, Sakellaris S, Papadopoulos M, Pirmettis I, Fronczek FR, Liapakis G, Fahmy H. Design, Synthesis, Structural Optimization, SAR, in silico Prediction of Physicochemical Properties and Pharmacological Evaluation of Novel & Potent Thiazolo[4,5-d]pyrimidine Corticotropin Releasing Factor (CRF) Receptor Antagonists. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 106084. PMID 34856350 DOI: 10.1016/j.ejps.2021.106084   
2021 Refaie MMM, Abdel-Gaber SA, Rahman SAAE, Hafez SMNA, Khalaf HM. Cardioprotective effects of bosentan in 5-fluorouracil-induced cardiotoxicity. Toxicology. 465: 153042. PMID 34800596 DOI: 10.1016/j.tox.2021.153042   
2021 Crocetti L, Vergelli C, Guerrini G, Giovannoni MP, Kirpotina LN, Khlebnikov AI, Ghelardini C, Di Cesare Mannelli L, Lucarini E, Schepetkin IA, Quinn MT. Pyridinone Derivatives as Interesting Formyl Peptide Receptor (FPR) Agonists for the Treatment of Rheumatoid Arthritis. Molecules (Basel, Switzerland). 26. PMID 34770992 DOI: 10.3390/molecules26216583   
2021 Pham N, Miller MD, Marty M. Using High-Throughput Screening to Evaluate Perturbations Potentially Linked to Neurobehavioral Outcomes: A Case Study Using Publicly Available Tools on FDA Batch-Certified Synthetic Food Dyes. Chemical Research in Toxicology. 34: 2319-2330. PMID 34705446 DOI: 10.1021/acs.chemrestox.1c00205   
2021 Wang M, Hou S, Liu Y, Li D, Lin J. Identification of Novel Antagonists Targeting Cannabinoid Receptor 2 Using a Multi-Step Virtual Screening Strategy. Molecules (Basel, Switzerland). 26. PMID 34771087 DOI: 10.3390/molecules26216679   
2021 Lou L, Li C, Wang J, Wu A, Zhang T, Ma Z, Chai L, Zhang D, Zhao Y, Nie B, Jin Q, Chen H, Liu WJ. Yiqi Huoxue preserves heart function by upregulating the Sigma-1 receptor in rats with myocardial infarction. Experimental and Therapeutic Medicine. 22: 1308. PMID 34630662 DOI: 10.3892/etm.2021.10743   
2021 Yang Y, Wang Y, Zuo A, Li C, Wang W, Jiang W, Zhang X, Che X, Zhang Y, Wu W, Cen X, Wang H, Tian J. Synthesis, biological, and structural explorations of a series of μ-opioid receptor (MOR) agonists with high G protein signaling bias. European Journal of Medicinal Chemistry. 113986. PMID 34802839 DOI: 10.1016/j.ejmech.2021.113986   
2021 Zarkin A, Jahan R, Uprety R, Zhang Y, McElhinny C, Snyder R, Gay E, Jewula G, Bool H, Clark SD, Runyon S. Identification of a Novel Neuropeptide S Receptor Antagonist Scaffold Based on the SHA-68 Core. Pharmaceuticals (Basel, Switzerland). 14. PMID 34681248 DOI: 10.3390/ph14101024   
2021 Guo J, Min D, Feng HJ. Genistein, a Natural Isoflavone, Alleviates Seizure-Induced Respiratory Arrest in DBA/1 Mice. Frontiers in Neurology. 12: 761912. PMID 34803895 DOI: 10.3389/fneur.2021.761912   
2021 Cossette C, Miller LA, Ye Q, Chourey S, Reddy CN, Rokach J, Powell WS. Targeting the oxoeicosanoid (OXE) receptor with a selective antagonist inhibits allergen-induced pulmonary inflammation in non-human primates. British Journal of Pharmacology. PMID 34766334 DOI: 10.1111/bph.15721   
2021 Ortuno MJ, Schneeberger M, Ilanges A, Marchildon F, Pellegrino K, Friedman JM, Ducy P. Melanocortin 4 receptor stimulation prevents anti-depressant-associated weight gain in mice caused by long-term fluoxetine exposure. The Journal of Clinical Investigation. PMID 34673574 DOI: 10.1172/JCI151976   
2021 Kai H, Horiguchi T, Kameyma T, Onodera N, Itoh N, Fujii Y, Ichihashi Y, Hirai K, Shintani T, Nakamura K, Minami K, Kasai E, Yoneda S, Murakami Y, Ogawa H, et al. Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 52: 128384. PMID 34587541 DOI: 10.1016/j.bmcl.2021.128384   
2021 Mann G, Kadiyala KG, Thirumal M, Tiwari AK, Datta A. Receptor mapping using methoxy phenyl piperazine derivative: Preclinical PET imaging. Bioorganic Chemistry. 117: 105429. PMID 34736134 DOI: 10.1016/j.bioorg.2021.105429   
2021 Bertron JL, Duvernay MT, Mitchell SG, Smith ST, Maeng JG, Blobaum AL, Davis DC, Meiler J, Hamm HE, Lindsley CW. Discovery and Optimization of a Novel Series of Competitive and Central Nervous System-Penetrant Protease-Activated Receptor 4 (PAR4) Inhibitors. Acs Chemical Neuroscience. PMID 34855359 DOI: 10.1021/acschemneuro.1c00557   
2021 Liu T, Yi TL, Yang DQ, Tao YX. Regulation of melanocortin-5 receptor pharmacology by two isoforms of MRAP2 in ricefield eel (Monopterus albus). General and Comparative Endocrinology. 113928. PMID 34653433 DOI: 10.1016/j.ygcen.2021.113928   
2021 Romero-Martínez BS, Montaño LM, Solís-Chagoyán H, Sommer B, Ramírez-Salinas GL, Pérez-Figueroa GE, Flores-Soto E. Possible Beneficial Actions of Caffeine in SARS-CoV-2. International Journal of Molecular Sciences. 22. PMID 34067243 DOI: 10.3390/ijms22115460   
2021 Okita K, Kato K, Shigemoto Y, Sato N, Matsumoto T, Matsuda H. Effects of an Adenosine A Receptor Antagonist on Striatal Dopamine D2-Type Receptor Availability: A Randomized Control Study Using Positron Emission Tomography. Frontiers in Neuroscience. 15: 729153. PMID 34588952 DOI: 10.3389/fnins.2021.729153   
2021 Jenkins L, Marsango S, Mancini S, Mahmud ZA, Morrison A, McElroy SP, Bennett KA, Barnes M, Tobin AB, Tikhonova IG, Milligan G. Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84. Acs Pharmacology & Translational Science. 4: 1598-1613. PMID 34661077 DOI: 10.1021/acsptsci.1c00151   
2021 Peters K, Dahlgren D, Lennernäs H, Sjöblom M. Melatonin-Activated Receptor Signaling Pathways Mediate Protective Effects on Surfactant-Induced Increase in Jejunal Mucosal Permeability in Rats. International Journal of Molecular Sciences. 22. PMID 34639101 DOI: 10.3390/ijms221910762   
2021 Jackson A, Werry EL, O'Brien-Brown J, Schiavini P, Wilkinson S, Wong ECN, McKenzie ADJ, Maximova A, Kassiou M. Pharmacological characterization of a structural hybrid P2X7R antagonist using ATP and LL-37. European Journal of Pharmacology. 914: 174667. PMID 34863711 DOI: 10.1016/j.ejphar.2021.174667   
2021 Reuter U, Krege JH, Lombard L, Gomez Valderas E, Krikke-Workel J, Dell-Agnello G, Dowsett SA, Buse DC. Lasmiditan efficacy in the acute treatment of migraine was independent of prior response to triptans: Findings from the CENTURION study. Cephalalgia : An International Journal of Headache. 3331024211048507. PMID 34644189 DOI: 10.1177/03331024211048507   
2021 Xu Q, Hu M, Li J, Ma X, Chu Z, Zhu Q, Zhang Y, Zhu P, Huang Y, He G. Discovery of novel brain-penetrant GluN2B NMDAR antagonists via pharmacophore-merging strategy as anti-stroke therapeutic agents. European Journal of Medicinal Chemistry. 227: 113876. PMID 34710748 DOI: 10.1016/j.ejmech.2021.113876