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Thomas J. Melia, Ph.D. - Publications

Affiliations: 
Cell Biology Yale University School of Medicine, New Haven, CT 
Area:
Macroautophagy, autophagy
Website:
http://medicine.yale.edu/labs/melia/www/Melia_Lab/Melia_Lab_.html
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49/66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Mannino PJ, Perun A, Surovstev I, Ader NR, Shao L, Melia TJ, King MC, Lusk CP. A quantitative ultrastructural timeline of nuclear autophagy reveals a role for dynamin-like protein 1 at the nuclear envelope. Biorxiv : the Preprint Server For Biology. PMID 38405892 DOI: 10.1101/2024.02.14.580336  0.338
2024 Wan N, Hong Z, Parson MAH, Korfhage JL, Burke JE, Melia TJ, Reinisch KM. Spartin-mediated lipid transfer facilitates lipid droplet turnover. Proceedings of the National Academy of Sciences of the United States of America. 121: e2314093121. PMID 38190532 DOI: 10.1073/pnas.2314093121  0.304
2023 Wan N, Hong Z, Parson MAH, Korfhage J, Burke JE, Melia TJ, Reinisch KM. Spartin-mediated lipid transfer facilitates lipid droplet turnover. Biorxiv : the Preprint Server For Biology. PMID 38076959 DOI: 10.1101/2023.11.29.569220  0.306
2023 Korfhage JL, Wan N, Elhan H, Kauffman L, Pineda M, Fuller DM, Thiam AR, Reinisch KM, Melia TJ. ATG2A-mediated bridge-like lipid transport regulates lipid droplet accumulation. Biorxiv : the Preprint Server For Biology. PMID 37645754 DOI: 10.1101/2023.08.14.553257  0.334
2023 Omrane M, Melia TJ, Thiam AR. LC3 conjugation to lipid droplets. Autophagy. PMID 37599471 DOI: 10.1080/15548627.2023.2249390  0.362
2023 Melia TJ. Growing thin - How bulk lipid transport drives expansion of the autophagosome membrane but not of its lumen. Current Opinion in Cell Biology. 83: 102190. PMID 37385155 DOI: 10.1016/j.ceb.2023.102190  0.4
2023 Omrane M, Ben M'Barek K, Santinho A, Nguyen N, Nag S, Melia TJ, Thiam AR. LC3B is lipidated to large lipid droplets during prolonged starvation for noncanonical autophagy. Developmental Cell. PMID 37315562 DOI: 10.1016/j.devcel.2023.05.009  0.379
2023 Olivas TJ, Wu Y, Yu S, Luan L, Choi P, Guinn ED, Nag S, De Camilli PV, Gupta K, Melia TJ. ATG9 vesicles comprise the seed membrane of mammalian autophagosomes. The Journal of Cell Biology. 222. PMID 37115958 DOI: 10.1083/jcb.202208088  0.458
2022 Hong Z, Adlakha J, Wan N, Guinn E, Giska F, Gupta K, Melia TJ, Reinisch KM. Mitoguardin-2-mediated lipid transfer preserves mitochondrial morphology and lipid droplet formation. The Journal of Cell Biology. 221. PMID 36282247 DOI: 10.1083/jcb.202207022  0.352
2022 Olivas TJ, Yu S, Wu Y, Luan L, Choi P, Gupta K, De Camilli P, Melia TJ. ATG9 Vesicles Are Incorporated Into Nascent Autophagosome Membranes. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 35556702 DOI: 10.1096/fasebj.2022.36.S1.0R457  0.427
2022 Melia TJ, Reinisch KM. A possible role for VPS13-family proteins in bulk lipid transfer, membrane expansion and organelle biogenesis. Journal of Cell Science. 135. PMID 35267021 DOI: 10.1242/jcs.259357  0.396
2021 Chandra S, Mannino PJ, Thaller DJ, Ader NR, King MC, Melia TJ, Lusk CP. Atg39 selectively captures inner nuclear membrane into lumenal vesicles for delivery to the autophagosome. The Journal of Cell Biology. 220. PMID 34714326 DOI: 10.1083/jcb.202103030  0.352
2021 Ghanbarpour A, Valverde DP, Melia TJ, Reinisch KM. A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33850023 DOI: 10.1073/pnas.2101562118  0.422
2021 Yang Y, Wu Z, Wang L, Zhou K, Xia K, Xiong Q, Liu L, Zhang Z, Chapman ER, Xiong Y, Melia TJ, Karatekin E, Gu H, Lin C. Sorting sub-150-nm liposomes of distinct sizes by DNA-brick-assisted centrifugation. Nature Chemistry. PMID 33785892 DOI: 10.1038/s41557-021-00667-5  0.405
2020 Nguyen N, Olivas TJ, Mires A, Jin J, Yu S, Luan L, Nag S, Kauffman KJ, Melia TJ. The insufficiency of ATG4A in macroautophagy. The Journal of Biological Chemistry. PMID 32732290 DOI: 10.1074/jbc.RA120.013897  0.351
2020 Melia TJ, Lystad AH, Simonsen A. Autophagosome biogenesis: From membrane growth to closure. The Journal of Cell Biology. 219. PMID 32357219 DOI: 10.1083/jcb.202002085  0.364
2019 Valverde DP, Yu S, Boggavarapu V, Kumar N, Lees JA, Walz T, Reinisch KM, Melia TJ. ATG2 transports lipids to promote autophagosome biogenesis. The Journal of Cell Biology. PMID 30952800 DOI: 10.1083/Jcb.201811139  0.386
2019 Lystad AH, Carlsson SR, de la Ballina LR, Kauffman KJ, Nag S, Yoshimori T, Melia TJ, Simonsen A. Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes. Nature Cell Biology. PMID 30778222 DOI: 10.1038/s41556-019-0274-9  0.443
2018 Kauffman KJ, Yu S, Jin J, Mugo B, Nguyen N, O'Brien A, Nag S, Lystad AH, Melia TJ. Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases. Autophagy. 1-56. PMID 29458288 DOI: 10.1080/15548627.2018.1437341  0.368
2017 Yu S, Melia TJ. The coordination of membrane fission and fusion at the end of autophagosome maturation. Current Opinion in Cell Biology. 47: 92-98. PMID 28463755 DOI: 10.1016/j.ceb.2017.03.010  0.373
2017 Nguyen N, Shteyn V, Melia TJ. Sensing Membrane Curvature in Macroautophagy. Journal of Molecular Biology. PMID 28088480 DOI: 10.1016/j.jmb.2017.01.006  0.44
2016 Holland P, Knævelsrud H, Søreng K, Mathai BJ, Lystad AH, Pankiv S, Bjørndal GT, Schultz SW, Lobert VH, Chan RB, Zhou B, Liestøl K, Carlsson SR, Melia TJ, Di Paolo G, et al. HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels. Nature Communications. 7: 13889. PMID 28004827 DOI: 10.1038/ncomms13889  0.332
2015 Horenkamp FA, Kauffman KJ, Kohler LJ, Sherwood RK, Krueger KP, Shteyn V, Roy CR, Melia TJ, Reinisch KM. The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs. Developmental Cell. 34: 569-76. PMID 26343456 DOI: 10.1016/J.Devcel.2015.08.010  0.438
2014 Dancourt J, Melia TJ. Lipidation of the autophagy proteins LC3 and GABARAP is a membrane-curvature dependent process. Autophagy. 10: 1470-1. PMID 24991828 DOI: 10.4161/auto.29468  0.451
2014 Nath S, Dancourt J, Shteyn V, Puente G, Fong WM, Nag S, Bewersdorf J, Yamamoto A, Antonny B, Melia TJ. Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3. Nature Cell Biology. 16: 415-24. PMID 24747438 DOI: 10.1038/Ncb2940  0.471
2013 Nath S, Dancourt J, Puente G, Nag S, Yamamoto A, Antonny B, Melia T. The Lipidation Machinery Involved in Autophagosome Growth is Only Functional on Highly Curved Membranes Biophysical Journal. 104: 97a. DOI: 10.1016/J.Bpj.2012.11.576  0.467
2012 Shi L, Shen QT, Kiel A, Wang J, Wang HW, Melia TJ, Rothman JE, Pincet F. SNARE proteins: one to fuse and three to keep the nascent fusion pore open. Science (New York, N.Y.). 335: 1355-9. PMID 22422984 DOI: 10.1126/Science.1214984  0.34
2012 Jotwani A, Richerson DN, Motta I, Julca-Zevallos O, Melia TJ. Approaches to the study of Atg8-mediated membrane dynamics in vitro. Methods in Cell Biology. 108: 93-116. PMID 22325599 DOI: 10.1016/B978-0-12-386487-1.00005-5  0.425
2011 Shi L, Kümmel D, Coleman J, Melia TJ, Giraudo CG. Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex. Molecular Biology of the Cell. 22: 4150-60. PMID 21900493 DOI: 10.1091/mbc.E11-02-0150  0.309
2011 Nair U, Jotwani A, Geng J, Gammoh N, Richerson D, Yen WL, Griffith J, Nag S, Wang K, Moss T, Baba M, McNew JA, Jiang X, Reggiori F, Melia TJ, et al. SNARE proteins are required for macroautophagy. Cell. 146: 290-302. PMID 21784249 DOI: 10.1016/J.Cell.2011.06.022  0.358
2010 Ji H, Coleman J, Yang R, Melia TJ, Rothman JE, Tareste D. Protein determinants of SNARE-mediated lipid mixing. Biophysical Journal. 99: 553-60. PMID 20643074 DOI: 10.1016/j.bpj.2010.04.060  0.469
2009 Giraudo CG, Garcia-Diaz A, Eng WS, Chen Y, Hendrickson WA, Melia TJ, Rothman JE. Alternative zippering as an on-off switch for SNARE-mediated fusion. Science (New York, N.Y.). 323: 512-6. PMID 19164750 DOI: 10.1126/Science.1166500  0.377
2009 Tareste D, Yamamoto A, Melia T. Membrane Fusion in Autophagy Biophysical Journal. 96: 359a. DOI: 10.1016/J.Bpj.2008.12.1811  0.463
2008 Tareste D, Shen J, Melia TJ, Rothman JE. SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes. Proceedings of the National Academy of Sciences of the United States of America. 105: 2380-5. PMID 18268324 DOI: 10.1073/Pnas.0712125105  0.382
2007 Li F, Pincet F, Perez E, Eng WS, Melia TJ, Rothman JE, Tareste D. Energetics and dynamics of SNAREpin folding across lipid bilayers. Nature Structural & Molecular Biology. 14: 890-6. PMID 17906638 DOI: 10.1038/nsmb1310  0.387
2007 Shen J, Tareste DC, Paumet F, Rothman JE, Melia TJ. Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell. 128: 183-95. PMID 17218264 DOI: 10.1016/J.Cell.2006.12.016  0.321
2006 Melia TJ, You D, Tareste DC, Rothman JE. Lipidic antagonists to SNARE-mediated fusion. The Journal of Biological Chemistry. 281: 29597-605. PMID 16887809 DOI: 10.1074/jbc.M601778200  0.41
2004 Zhang Z, Melia TJ, He F, Yuan C, McGough A, Schmid MF, Wensel TG. How a G protein binds a membrane. The Journal of Biological Chemistry. 279: 33937-45. PMID 15173184 DOI: 10.1074/Jbc.M403404200  0.67
2004 Fix M, Melia TJ, Jaiswal JK, Rappoport JZ, You D, Söllner TH, Rothman JE, Simon SM. Imaging single membrane fusion events mediated by SNARE proteins. Proceedings of the National Academy of Sciences of the United States of America. 101: 7311-6. PMID 15123811 DOI: 10.1073/pnas.0401779101  0.363
2003 Scott BL, Van Komen JS, Liu S, Weber T, Melia TJ, McNew JA. Liposome fusion assay to monitor intracellular membrane fusion machines. Methods in Enzymology. 372: 274-300. PMID 14610819 DOI: 10.1016/S0076-6879(03)72016-3  0.379
2003 Hu C, Ahmed M, Melia TJ, Söllner TH, Mayer T, Rothman JE. Fusion of cells by flipped SNAREs. Science (New York, N.Y.). 300: 1745-9. PMID 12805548 DOI: 10.1126/science.1084909  0.401
2002 Melia TJ, Weber T, McNew JA, Fisher LE, Johnston RJ, Parlati F, Mahal LK, Sollner TH, Rothman JE. Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins. The Journal of Cell Biology. 158: 929-40. PMID 12213837 DOI: 10.1083/Jcb.200112081  0.322
2001 He W, Melia TJ, Cowan CW, Wensel TG. Dependence of RGS9-1 membrane attachment on its C-terminal tail. The Journal of Biological Chemistry. 276: 48961-6. PMID 11677233 DOI: 10.1074/Jbc.M107428200  0.648
2000 McNew JA, Weber T, Parlati F, Johnston RJ, Melia TJ, Söllner TH, Rothman JE. Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors. The Journal of Cell Biology. 150: 105-17. PMID 10893260 DOI: 10.1083/Jcb.150.1.105  0.444
2000 Melia TJ, Malinski JA, He F, Wensel TG. Enhancement of phototransduction protein interactions by lipid surfaces. The Journal of Biological Chemistry. 275: 3535-42. PMID 10652348 DOI: 10.1074/Jbc.275.5.3535  0.664
1999 Melia TJ, Sowa ME, Schutze L, Wensel TG. Formation of helical protein assemblies of IgG and transducin on varied lipid tubules. Journal of Structural Biology. 128: 119-30. PMID 10600566 DOI: 10.1006/Jsbi.1999.4151  0.647
1997 Melia TJ, Cowan CW, Angleson JK, Wensel TG. A comparison of the efficiency of G protein activation by ligand-free and light-activated forms of rhodopsin. Biophysical Journal. 73: 3182-91. PMID 9414230 DOI: 10.1016/S0006-3495(97)78344-9  0.544
1996 Malinski JA, Melia TJ, Wensel TG. Stoichiometric activaton of retinal rod cGMP phosphodiesterase by Gtα-GTPγS Investigative Ophthalmology and Visual Science. 37: S809.  0.48
1996 Melia TJ, Malinski JA, McGough A, Wensel TG. Ordered two-dimensional and helical arrays of transducin bound to lipid surfaces Investigative Ophthalmology and Visual Science. 37: S238.  0.53
Low-probability matches (unlikely to be authored by this person)
2007 Melia TJ. Putting the clamps on membrane fusion: how complexin sets the stage for calcium-mediated exocytosis. Febs Letters. 581: 2131-9. PMID 17350005 DOI: 10.1016/j.febslet.2007.02.066  0.292
2008 Giraudo CG, Garcia-Diaz A, Eng WS, Yamamoto A, Melia TJ, Rothman JE. Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. The Journal of Biological Chemistry. 283: 21211-9. PMID 18499660 DOI: 10.1074/Jbc.M803478200  0.284
2011 Xu Y, Melia TJ, Toomre DK. Using light to see and control membrane traffic. Current Opinion in Chemical Biology. 15: 822-30. PMID 22079055 DOI: 10.1016/j.cbpa.2011.10.016  0.265
2012 Choy A, Dancourt J, Mugo B, O'Connor TJ, Isberg RR, Melia TJ, Roy CR. The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science (New York, N.Y.). 338: 1072-6. PMID 23112293 DOI: 10.1126/Science.1227026  0.252
2022 Shen Q, Xiong Q, Zhou K, Feng Q, Liu L, Tian T, Wu C, Xiong Y, Melia TJ, Lusk CP, Lin C. Functionalized DNA-Origami-Protein Nanopores Generate Large Transmembrane Channels with Programmable Size-Selectivity. Journal of the American Chemical Society. PMID 36577119 DOI: 10.1021/jacs.2c11226  0.249
2021 Reinisch KM, Chen XW, Melia TJ. "VTT"-domain proteins VMP1 and TMEM41B function in lipid homeostasis globally and locally as ER scramblases. Contact (Thousand Oaks (Ventura County, Calif.)). 4. PMID 34447902 DOI: 10.1177/25152564211024494  0.247
2022 Fuller DM, Melia TJ. Closing the autophagosome is easy-PC. The Embo Journal. 42: e113046. PMID 36478568 DOI: 10.15252/embj.2022113046  0.246
2010 Filimonenko M, Isakson P, Finley KD, Anderson M, Jeong H, Melia TJ, Bartlett BJ, Myers KM, Birkeland HC, Lamark T, Krainc D, Brech A, Stenmark H, Simonsen A, Yamamoto A. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Molecular Cell. 38: 265-79. PMID 20417604 DOI: 10.1016/J.Molcel.2010.04.007  0.191
2009 Jeong H, Then F, Melia TJ, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell. 137: 60-72. PMID 19345187 DOI: 10.1016/J.Cell.2009.03.018  0.169
2005 Giraudo CG, Hu C, You D, Slovic AM, Mosharov EV, Sulzer D, Melia TJ, Rothman JE. SNAREs can promote complete fusion and hemifusion as alternative outcomes. The Journal of Cell Biology. 170: 249-60. PMID 16027221 DOI: 10.1083/jcb.200501093  0.138
2006 Giraudo CG, Eng WS, Melia TJ, Rothman JE. A clamping mechanism involved in SNARE-dependent exocytosis. Science (New York, N.Y.). 313: 676-80. PMID 16794037 DOI: 10.1126/science.1129450  0.135
2018 Fisher PDE, Shen Q, Akpinar B, Davis LK, Chung KKH, Baddeley D, Saric A, Melia TJ, Hoogenboom BW, Lin C, Lusk CP. A Programmable DNA Origami Platform for Organizing Intrinsically Disordered Nucleoporins within Nanopore Confinement. Acs Nano. PMID 29350911 DOI: 10.1021/Acsnano.7B08044  0.135
2021 Shen Q, Tian T, Xiong Q, Ellis Fisher PD, Xiong Y, Melia TJ, Lusk CP, Lin C. DNA-Origami NanoTrap for Studying the Selective Barriers Formed by Phenylalanine-Glycine-Rich Nucleoporins. Journal of the American Chemical Society. PMID 34324340 DOI: 10.1021/jacs.1c05550  0.132
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Melia TJ, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.13
2019 Hill SE, Kauffman KJ, Krout M, Richmond JE, Melia TJ, Colón-Ramos DA. Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2. Developmental Cell. PMID 30880001 DOI: 10.1016/J.Devcel.2019.02.013  0.113
2011 Klionsky DJ, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz D, Jäättelä M, Kroemer G, ... ... Melia TJ, et al. A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy. 7: 1273-94. PMID 21997368 DOI: 10.4161/Auto.7.11.17661  0.09
2012 Johnson CW, Melia TJ, Yamamoto A. Modulating macroautophagy: a neuronal perspective. Future Medicinal Chemistry. 4: 1715-31. PMID 22924509 DOI: 10.4155/Fmc.12.112  0.052
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