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Saul A. Villeda - Publications

Affiliations: 
University of California, San Francisco, San Francisco, CA 
Area:
neuroscience, aging, stem cell, cognition, neuroimmunology
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46/59 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Stevenson ME, Bieri G, Kaletsky R, St Ange J, Remesal L, Pratt KJB, Zhou S, Weng Y, Murphy CT, Villeda SA. Neuronal activation of G EGL-30/GNAQ late in life rejuvenates cognition across species. Cell Reports. 42: 113151. PMID 37713310 DOI: 10.1016/j.celrep.2023.113151  0.416
2023 Schroer AB, Ventura PB, Sucharov J, Misra R, Chui MKK, Bieri G, Horowitz AM, Smith LK, Encabo K, Tenggara I, Couthouis J, Gross JD, Chan JM, Luke A, Villeda SA. Platelet factors attenuate inflammation and rescue cognition in ageing. Nature. PMID 37587343 DOI: 10.1038/s41586-023-06436-3  0.505
2023 Park C, Hahn O, Gupta S, Moreno AJ, Marino F, Kedir B, Wang D, Villeda SA, Wyss-Coray T, Dubal DB. Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice. Nature Aging. PMID 37587231 DOI: 10.1038/s43587-023-00468-0  0.61
2023 Leiter O, Brici D, Fletcher SJ, Yong XLH, Widagdo J, Matigian N, Schroer AB, Bieri G, Blackmore DG, Bartlett PF, Anggono V, Villeda SA, Walker TL. Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice. Nature Communications. 14: 4375. PMID 37587147 DOI: 10.1038/s41467-023-39873-9  0.364
2023 Braz JM, Hamel K, Craik V, Rodriguez-Rosado S, Bhardwaj K, Jewell M, Bieri G, Villeda SA, Basbaum AI. Pain and itch processing in aged mice. The Journal of Pain. PMID 37482234 DOI: 10.1016/j.jpain.2023.07.018  0.332
2023 Pratt KJB, Shea JM, Remesal-Gomez L, Bieri G, Smith LK, Couthouis J, Chen CP, Roy IJ, Gontier G, Villeda SA. Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function. Cell Reports. 42: 111926. PMID 36719799 DOI: 10.1016/j.celrep.2022.111926  0.302
2023 Bieri G, Schroer AB, Villeda SA. Blood-to-brain communication in aging and rejuvenation. Nature Neuroscience. PMID 36646876 DOI: 10.1038/s41593-022-01238-8  0.43
2022 Pratt KJB, Shea JM, Remesal-Gomez L, Bieri G, Smith LK, Couthouis J, Chen CP, Roy IJ, Gontier G, Villeda SA. Loss of neuronal Tet2 enhances hippocampal-dependent cognitive function. Cell Reports. 41: 111612. PMID 36351399 DOI: 10.1016/j.celrep.2022.111612  0.319
2022 Luo J, Nguyen A, Villeda S, Zhang H, Ding Z, Lindsey D, Bieri G, Castellano JM, Beaupre GS, Wyss-Coray T. Corrigendum: Long-Term Cognitive Impairments and Pathological Alterations in a Mouse Model of Repetitive Mild Traumatic Brain Injury. Frontiers in Neurology. 13: 730576. PMID 35847232 DOI: 10.3389/fneur.2022.730576  0.673
2021 Ho TT, Dellorusso PV, Verovskaya EV, Bakker ST, Flach J, Smith LK, Ventura PB, Lansinger OM, Hérault A, Zhang SY, Kang YA, Mitchell CA, Villeda SA, Passegué E. Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions. The Journal of Experimental Medicine. 218. PMID 34032859 DOI: 10.1084/jem.20210223  0.387
2020 Smith LK, Verovskaya E, Bieri G, Horowitz AM, von Ungern-Sternberg SNI, Lin K, Seizer P, Passegué E, Villeda SA. The aged hematopoietic system promotes hippocampal-dependent cognitive decline. Aging Cell. 19: e13192. PMID 33073926 DOI: 10.1111/Acel.13192  0.593
2020 Shea JM, Villeda SA. Dampening the Power of the Brain-When Aging Meets Cognition. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 75: 1607-1608. PMID 32936914 DOI: 10.1093/Gerona/Glaa170  0.454
2020 White CW, Fan X, Maynard JC, Wheatley EG, Bieri G, Couthouis J, Burlingame AL, Villeda SA. Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 32848054 DOI: 10.1073/Pnas.2007439117  0.762
2020 Brigger D, Riether C, van Brummelen R, Mosher KI, Shiu A, Ding Z, Zbären N, Gasser P, Guntern P, Yousef H, Castellano JM, Storni F, Graff-Radford N, Britschgi M, Grandgirard D, ... ... Villeda SA, et al. Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age. Nature Metabolism. PMID 32694825 DOI: 10.1038/s42255-020-0228-3  0.78
2020 Horowitz AM, Fan X, Bieri G, Smith LK, Sanchez-Diaz CI, Schroer AB, Gontier G, Casaletto KB, Kramer JH, Williams KE, Villeda SA. Blood factors transfer beneficial effects of exercise on neurogenesis and cognition to the aged brain. Science (New York, N.Y.). 369: 167-173. PMID 32646997 DOI: 10.1126/Science.Aaw2622  0.676
2020 Nguyen QH, Witt RG, Wang B, Eikani C, Shea J, Smith LK, Boyle G, Cadaoas J, Sper R, MacKenzie JD, Villeda S, MacKenzie TC. Tolerance induction and microglial engraftment after fetal therapy without conditioning in mice with Mucopolysaccharidosis type VII. Science Translational Medicine. 12. PMID 32102934 DOI: 10.1126/Scitranslmed.Aay8980  0.382
2019 White CW, Pratt K, Villeda SA. OPCs on a Diet: A Youthful Serving of Remyelination. Cell Metabolism. 30: 1004-1006. PMID 31801054 DOI: 10.1016/J.Cmet.2019.11.009  0.39
2019 Wheatley EG, Albarran E, White CW, Bieri G, Sanchez-Diaz C, Pratt K, Snethlage CE, Ding JB, Villeda SA. Neuronal O-GlcNAcylation Improves Cognitive Function in the Aged Mouse Brain. Current Biology : Cb. PMID 31588002 DOI: 10.1016/J.Cub.2019.08.003  0.778
2019 Sousa-Victor P, Neves J, Cedron-Craft W, Ventura PB, Liao CY, Riley RR, Soifer I, van Bruggen N, Kolumam GA, Villeda SA, Lamba DA, Jasper H. MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage. Nature Metabolism. 1: 276-290. PMID 31489403 DOI: 10.1038/s42255-018-0023-6  0.305
2019 Austad SN, Wood MA, Villeda SA, Voss JL, Sahay A, Albert M. Innovative approaches in cognitive aging. Neurobiology of Aging. PMID 31277894 DOI: 10.1016/J.Neurobiolaging.2019.04.013  0.458
2019 Schroer AB, Horowitz AM, Villeda SA. Platelets Give a Running Start to Adult Hippocampal Neurogenesis. Stem Cell Reports. 12: 643-646. PMID 30951653 DOI: 10.1016/J.Stemcr.2019.03.007  0.342
2019 Villeda S. Mechanisms Of Brain Rejuvenation Innovation in Aging. 3. DOI: 10.1093/Geroni/Igz038.2177  0.522
2019 Nguyen Q, Witt R, Smith L, Shea J, Wang B, Eikani C, Villeda S, MacKenzie T. Fetal enzyme replacement and stem cell transplantation in murine Sly syndrome targeting microglia Molecular Genetics and Metabolism. 126: S107. DOI: 10.1016/J.Ymgme.2018.12.270  0.381
2018 Bieri G, Lucin KM, O'Brien CE, Zhang H, Villeda SA, Wyss-Coray T. Proteolytic cleavage of Beclin 1 exacerbates neurodegeneration. Molecular Neurodegeneration. 13: 68. PMID 30594228 DOI: 10.1186/S13024-018-0302-4  0.546
2018 Gontier G, Iyer M, Shea JM, Bieri G, Wheatley EG, Ramalho-Santos M, Villeda SA. Tet2 Rescues Age-Related Regenerative Decline and Enhances Cognitive Function in the Adult Mouse Brain. Cell Reports. 22: 1974-1981. PMID 29466726 DOI: 10.1016/J.Celrep.2018.02.001  0.805
2017 Smith LK, White CW, Villeda SA. The systemic environment: at the interface of aging and adult neurogenesis. Cell and Tissue Research. PMID 29124393 DOI: 10.1007/S00441-017-2715-8  0.554
2017 Deczkowska A, Matcovitch-Natan O, Tsitsou-Kampeli A, Ben-Hamo S, Dvir-Szternfeld R, Spinrad A, Singer O, David E, Winter DR, Smith LK, Kertser A, Baruch K, Rosenzweig N, Terem A, Prinz M, ... Villeda S, et al. Mef2C restrains microglial inflammatory response and is lost in brain ageing in an IFN-I-dependent manner. Nature Communications. 8: 717. PMID 28959042 DOI: 10.1038/S41467-017-00769-0  0.534
2017 Horowitz AM, Villeda SA. Therapeutic potential of systemic brain rejuvenation strategies for neurodegenerative disease. F1000research. 6: 1291. PMID 28815019 DOI: 10.12688/F1000Research.11437.1  0.507
2017 Fan X, Wheatley EG, Villeda SA. Mechanisms of Hippocampal Aging and the Potential for Rejuvenation. Annual Review of Neuroscience. PMID 28441118 DOI: 10.1146/Annurev-Neuro-072116-031357  0.786
2016 Udeochu JC, Shea JM, Villeda SA. Microglia communication: Parallels between aging and Alzheimer's disease. Clinical & Experimental Neuroimmunology. 7: 114-125. PMID 27840659 DOI: 10.1111/Cen3.12307  0.798
2016 Middeldorp J, Lehallier B, Villeda SA, Miedema SS, Evans E, Czirr E, Zhang H, Luo J, Stan T, Mosher KI, Masliah E, Wyss-Coray T. Preclinical Assessment of Young Blood Plasma for Alzheimer Disease. Jama Neurology. PMID 27598869 DOI: 10.1001/Jamaneurol.2016.3185  0.742
2015 Armanios M, de Cabo R, Mannick J, Partridge L, van Deursen J, Villeda S. Translational strategies in aging and age-related disease. Nature Medicine. 21: 1395-9. PMID 26646495 DOI: 10.1038/Nm.4004  0.387
2015 Gontier G, Lin K, Villeda SA. Fat Chance for Neural Stem Cells in Alzheimer's Disease. Cell Stem Cell. 17: 373-4. PMID 26431177 DOI: 10.1016/J.Stem.2015.09.006  0.381
2015 Smith LK, He Y, Park JS, Bieri G, Snethlage CE, Lin K, Gontier G, Wabl R, Plambeck KE, Udeochu J, Wheatley EG, Bouchard J, Eggel A, Narasimha R, Grant JL, ... ... Villeda SA, et al. β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nature Medicine. PMID 26147761 DOI: 10.1038/Nm.3898  0.8
2015 Bouchard J, Villeda SA. Aging and brain rejuvenation as systemic events. Journal of Neurochemistry. 132: 5-19. PMID 25327899 DOI: 10.1111/Jnc.12969  0.54
2014 He Y, Zhang H, Yung A, Villeda SA, Jaeger PA, Olayiwola O, Fainberg N, Wyss-Coray T. ALK5-dependent TGF-β signaling is a major determinant of late-stage adult neurogenesis. Nature Neuroscience. 17: 943-52. PMID 24859199 DOI: 10.1038/Nn.3732  0.774
2014 Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, et al. Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nature Medicine. 20: 659-63. PMID 24793238 DOI: 10.1038/Nm.3569  0.778
2014 Luo J, Nguyen A, Villeda S, Zhang H, Ding Z, Lindsey D, Bieri G, Castellano JM, Beaupre GS, Wyss-Coray T. Long-term cognitive impairments and pathological alterations in a mouse model of repetitive mild traumatic brain injury. Frontiers in Neurology. 5: 12. PMID 24550885 DOI: 10.3389/Fneur.2014.00012  0.701
2013 Luo J, Elwood F, Britschgi M, Villeda S, Zhang H, Ding Z, Zhu L, Alabsi H, Getachew R, Narasimhan R, Wabl R, Fainberg N, James ML, Wong G, Relton J, et al. Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival. The Journal of Experimental Medicine. 210: 157-72. PMID 23296467 DOI: 10.1084/Jem.20120412  0.729
2013 Villeda SA, Wyss-Coray T. The circulatory systemic environment as a modulator of neurogenesis and brain aging. Autoimmunity Reviews. 12: 674-7. PMID 23201925 DOI: 10.1016/J.Autrev.2012.10.014  0.715
2011 Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, Stan TM, Fainberg N, Ding Z, Eggel A, Lucin KM, Czirr E, Park JS, Couillard-Després S, Aigner L, et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature. 477: 90-4. PMID 21886162 DOI: 10.1038/Nature10357  0.823
2011 Moriyama M, Fukuhara T, Britschgi M, He Y, Narasimhan R, Villeda S, Molina H, Huber BT, Holers M, Wyss-Coray T. Complement receptor 2 is expressed in neural progenitor cells and regulates adult hippocampal neurogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 3981-9. PMID 21411641 DOI: 10.1523/Jneurosci.3617-10.2011  0.731
2009 Renault VM, Rafalski VA, Morgan AA, Salih DA, Brett JO, Webb AE, Villeda SA, Thekkat PU, Guillerey C, Denko NC, Palmer TD, Butte AJ, Brunet A. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell. 5: 527-39. PMID 19896443 DOI: 10.1016/J.Stem.2009.09.014  0.757
2008 Villeda S, Wyss-Coray T. Microglia--a wrench in the running wheel? Neuron. 59: 527-9. PMID 18760689 DOI: 10.1016/J.Neuron.2008.08.005  0.535
2006 Villeda SA, Akopians AL, Babayan AH, Basbaum AI, Phelps PE. Absence of Reelin results in altered nociception and aberrant neuronal positioning in the dorsal spinal cord. Neuroscience. 139: 1385-96. PMID 16580148 DOI: 10.1016/J.Neuroscience.2006.01.042  0.622
2004 Kubasak MD, Brooks R, Chen S, Villeda SA, Phelps PE. Developmental distribution of reelin-positive cells and their secreted product in the rodent spinal cord. The Journal of Comparative Neurology. 468: 165-78. PMID 14648677 DOI: 10.1002/Cne.10946  0.635
Low-probability matches (unlikely to be authored by this person)
2019 Schneider C, Lee J, Koga S, Ricardo-Gonzalez RR, Nussbaum JC, Smith LK, Villeda SA, Liang HE, Locksley RM. Tissue-Resident Group 2 Innate Lymphoid Cells Differentiate by Layered Ontogeny and In Situ Perinatal Priming. Immunity. PMID 31128962 DOI: 10.1016/J.Immuni.2019.04.019  0.291
2018 Nguyen QL, Witt RG, Wang B, Shea J, Villeda S, Mackenzie TC. Hematopoietic Stem Cell Transplantation Using a Non-Toxic Regimen to Ablate the Fetal Bone Marrow Niche Enables Engraftment of Brain Microglial Cells Journal of the American College of Surgeons. 227: S252-S253. DOI: 10.1016/J.Jamcollsurg.2018.07.517  0.279
2023 de Sousa DMB, Poupardin R, Villeda SA, Schroer AB, Fröhlich T, Frey V, Staffen W, Mrowetz H, Altendorfer B, Unger MS, Iglseder B, Paulweber B, Trinka E, Cadamuro J, Drerup M, et al. The platelet transcriptome and proteome in Alzheimer's disease and aging: an exploratory cross-sectional study. Frontiers in Molecular Biosciences. 10: 1196083. PMID 37457829 DOI: 10.3389/fmolb.2023.1196083  0.277
2016 Zhang Y, Roth TL, Gray EE, Chen H, Rodda LB, Liang Y, Ventura P, Villeda S, Crocker PR, Cyster JG. Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node. Elife. 5. PMID 27487469 DOI: 10.7554/Elife.18156  0.247
2023 Villeda S, Brown-Borg H, Anderson R. Neurobiology of Aging: New Insights From Across the Research Spectrum. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 78: 869-871. PMID 37264524 DOI: 10.1093/gerona/glad110  0.241
2021 Lin K, Bieri G, Gontier G, Müller S, Smith LK, Snethlage CE, White CW, Maybury-Lewis SY, Villeda SA. MHC class I H2-Kb negatively regulates neural progenitor cell proliferation by inhibiting FGFR signaling. Plos Biology. 19: e3001311. PMID 34181639 DOI: 10.1371/journal.pbio.3001311  0.22
2018 Lee J, Schneider C, Liang H, Ricardo-Gonzalez R, Nussbaum J, Smith L, Villeda S, Locksley R. 1021 Origin of type 2 innate lymphoid cells in the skin Journal of Investigative Dermatology. 138: S173. DOI: 10.1016/J.Jid.2018.03.1033  0.218
2024 Clarke MT, Remesal L, Lentz L, Tan DJ, Young D, Thapa S, Namduri S, Borges B, Kirn G, Valencia J, Lopez ME, Lu JH, Shiow LR, Dindot S, Villeda S, et al. Prenatal delivery of a therapeutic antisense oligonucleotide achieves broad biodistribution in the brain and ameliorates Angelman Syndrome phenotype in mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 38327047 DOI: 10.1016/j.ymthe.2024.02.004  0.208
2022 Yu D, Li T, Delpech JC, Zhu B, Kishore P, Koshi T, Luo R, Pratt KJB, Popova G, Nowakowski TJ, Villeda SA, Piao X. Microglial GPR56 is the molecular target of maternal immune activation-induced parvalbumin-positive interneuron deficits. Science Advances. 8: eabm2545. PMID 35544642 DOI: 10.1126/sciadv.abm2545  0.202
2016 Zhang Y, Roth TL, Gray EE, Chen H, Rodda LB, Liang Y, Ventura P, Villeda S, Crocker PR, Cyster JG. Author response: Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node Elife. DOI: 10.7554/Elife.18156.029  0.19
2023 Babey ME, Krause WC, Herber CB, Chen K, Nikkanen J, Rodriquez R, Zhang X, Castro-Navarro F, Wang Y, Villeda S, Lane NE, Scheller EL, Chan CKF, Ambrosi TH, Ingraham HA. Brain-Derived CCN3 Is An Osteoanabolic Hormone That Sustains Bone in Lactating Females. Biorxiv : the Preprint Server For Biology. PMID 37693376 DOI: 10.1101/2023.08.28.554707  0.159
2022 Chow LS, Gerszten RE, Taylor JM, Pedersen BK, van Praag H, Trappe S, Febbraio MA, Galis ZS, Gao Y, Haus JM, Lanza IR, Lavie CJ, Lee CH, Lucia A, Moro C, ... ... Villeda S, et al. Exerkines in health, resilience and disease. Nature Reviews. Endocrinology. PMID 35304603 DOI: 10.1038/s41574-022-00641-2  0.134
2022 Chow LS, Gerszten RE, Taylor JM, Pedersen BK, van Praag H, Trappe S, Febbraio MA, Galis ZS, Gao Y, Haus JM, Lanza IR, Lavie CJ, Lee CH, Lucia A, Moro C, ... ... Villeda S, et al. Reply to 'Lactate as a major myokine and exerkine'. Nature Reviews. Endocrinology. PMID 35915255 DOI: 10.1038/s41574-022-00726-y  0.019
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