Dilshan S. Harischandra - Related publications

University of Pennsylvania, Philadelphia, PA, United States 
Neurodegenerative disease, Protein aggregation, metal neurotoxicity
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Behl T, Madaan P, Sehgal A, Singh S, Sharma N, Bhatia S, Al-Harrasi A, Chigurupati S, Alrashdi I, Bungau SG. Elucidating the Neuroprotective Role of PPARs in Parkinson's Disease: A Neoteric and Prospective Target. International Journal of Molecular Sciences. 22. PMID 34576325 DOI: 10.3390/ijms221810161   
2021 Guo Y, Ma Z, Ning X, Chen Y, Tian C, Wang X, Zhang Z, Liu J. A Novel Synthetic Precursor of Styryl Sulfone Neuroprotective Agents Inhibits Neuroinflammatory Responses and Oxidative Stress Damage through the P38 Signaling Pathway in the Cell and Animal Model of Parkinson's Disease. Molecules (Basel, Switzerland). 26. PMID 34500807 DOI: 10.3390/molecules26175371   
2021 Kung HC, Lin KJ, Kung CT, Lin TK. Oxidative Stress, Mitochondrial Dysfunction, and Neuroprotection of Polyphenols with Respect to Resveratrol in Parkinson's Disease. Biomedicines. 9. PMID 34440122 DOI: 10.3390/biomedicines9080918   
2021 Chen Z, Rasheed M, Deng Y. The epigenetic mechanisms involved in mitochondrial dysfunction: Implication for Parkinson's disease. Brain Pathology (Zurich, Switzerland). e13012. PMID 34414627 DOI: 10.1111/bpa.13012   
2021 Guo Q, Wang B, Wang X, Smith WW, Zhu Y, Liu Z. Activation of Nrf2 in Astrocytes Suppressed PD-Like Phenotypes via Antioxidant and Autophagy Pathways in Rat and Drosophila Models. Cells. 10. PMID 34440619 DOI: 10.3390/cells10081850   
2021 Xu Z, Qu A, Wang W, Lu M, Shi B, Chen C, Hao C, Xu L, Sun M, Xu C, Kuang H. Facet-dependent Biodegradable Mn O Nanoparticles for Ameliorating Parkinson's Disease. Advanced Healthcare Materials. e2101316. PMID 34601811 DOI: 10.1002/adhm.202101316   
2021 Ahn EH, Lei K, Kang SS, Wang ZH, Liu X, Hong W, Wang YT, Edgington-Mitchell LE, Jin L, Ye K. Mitochondrial dysfunction triggers the pathogenesis of Parkinson's disease in neuronal C/EBPβ transgenic mice. Molecular Psychiatry. PMID 34489530 DOI: 10.1038/s41380-021-01284-x   
2021 Seo MH, Yeo S. Decrease Associated with Alpha-Synuclein Increase in Muscles of MPTP-Induced Parkinson's Disease Mice. International Journal of Molecular Sciences. 22. PMID 34502283 DOI: 10.3390/ijms22179375   
2021 Martín-Montañez E, Valverde N, Ladrón de Guevara-Miranda D, Lara E, Romero-Zerbo YS, Millon C, Boraldi F, Ávila-Gámiz F, Pérez-Cano AM, Garrido-Gil P, Labandeira-Garcia JL, Santin LJ, Pavia J, Garcia-Fernandez M. Insulin-like growth factor II prevents oxidative and neuronal damage in cellular and mice models of Parkinson's disease. Redox Biology. 46: 102095. PMID 34418603 DOI: 10.1016/j.redox.2021.102095   
2021 Fenner BM, Fenner ME, Prowse N, Hayley SP. LRRK2 and WAVE2 regulate microglial-transition through distinct morphological phenotypes to induce neurotoxicity in a novel two-hit in vitro model of neurodegeneration. Journal of Cellular Physiology. PMID 34543438 DOI: 10.1002/jcp.30588   
2021 Lengyel-Zhand Z, Puentes LN, Mach RH. PARkinson's: From cellular mechanisms to potential therapeutics. Pharmacology & Therapeutics. 107968. PMID 34391789 DOI: 10.1016/j.pharmthera.2021.107968   
2021 Mani S, Sevanan M, Krishnamoorthy A, Sekar S. A systematic review of molecular approaches that link mitochondrial dysfunction and neuroinflammation in Parkinson's disease. Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. PMID 34480241 DOI: 10.1007/s10072-021-05551-1   
2021 Yang X, Zhang Y, Chen Y, He X, Qian Y, Xu S, Gao C, Mo C, Chen S, Xiao Q. LncRNA HOXA-AS2 regulates microglial polarization via recruitment of PRC2 and epigenetic modification of PGC-1α expression. Journal of Neuroinflammation. 18: 197. PMID 34511122 DOI: 10.1186/s12974-021-02267-z   
2021 Burtscher J, Syed MMK, Keller MA, Lashuel HA, Millet GP. Fatal attraction - The role of hypoxia when alpha-synuclein gets intimate with mitochondria. Neurobiology of Aging. 107: 128-141. PMID 34428721 DOI: 10.1016/j.neurobiolaging.2021.07.017   
2021 Zhang H, Wang Z, Hu K, Liu H. Downregulation of long noncoding RNA SNHG7 protects against inflammation and apoptosis in Parkinson's disease model by targeting the miR-425-5p/TRAF5/NF-κB axis. Journal of Biochemical and Molecular Toxicology. e22867. PMID 34369042 DOI: 10.1002/jbt.22867   
2021 Wang S, Wen Q, Xiong B, Zhang L, Yu X, Ouyang X. LncRNA NEAT1 knockdown ameliorates MPP-induced cell injury through miR-519a-3p/SP1 axis in Parkinson's disease. World Neurosurgery. PMID 34508910 DOI: 10.1016/j.wneu.2021.08.147   
2021 Huang Y, Liu Y, Huang J, Gao L, Wu Z, Wang L, Fan L. Let‑7b‑5p promotes cell apoptosis in Parkinson's disease by targeting HMGA2. Molecular Medicine Reports. 24. PMID 34558637 DOI: 10.3892/mmr.2021.12461   
2021 Rosenbusch KE, Oun A, Sanislav O, Lay ST, Keizer-Gunnink I, Annesley SJ, Fisher PR, Dolga AM, Kortholt A. A Conserved Role for LRRK2 and Roco Proteins in the Regulation of Mitochondrial Activity. Frontiers in Cell and Developmental Biology. 9: 734554. PMID 34568343 DOI: 10.3389/fcell.2021.734554   
2021 Lestón Pinilla L, Ugun-Klusek A, Rutella S, De Girolamo LA. Hypoxia Signaling in Parkinson's Disease: There Is Use in Asking "What HIF?" Biology. 10. PMID 34439955 DOI: 10.3390/biology10080723   
2021 Li DW, Qi XD, Zhang CH, Sun WP. Annexin A2 degradation contributes to dopaminergic cell apoptosis via regulating p53 in neurodegenerative conditions. Neuroreport. PMID 34494994 DOI: 10.1097/WNR.0000000000001721   
2021 Duangjan C, Rangsinth P, Zhang S, Gu X, Wink M, Tencomnao T. Neuroprotective Effects of Leaf Extract against HO/Glutamate-Induced Toxicity in Cultured Neuronal Cells and Aβ-Induced Toxicity in . Biology. 10. PMID 34440032 DOI: 10.3390/biology10080800   
2021 Asanuma M, Miyazaki I. Glutathione and Related Molecules in Parkinsonism. International Journal of Molecular Sciences. 22. PMID 34445395 DOI: 10.3390/ijms22168689   
2021 Krzystek TJ, Banerjee R, Thurston L, Huang J, Swinter K, Rahman SN, Falzone TL, Gunawardena S. Differential mitochondrial roles for α-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation. Cell Death & Disease. 12: 796. PMID 34404758 DOI: 10.1038/s41419-021-04046-3   
2021 Ge X, Wang Y, Yu S, Cao X, Chen Y, Cheng Q, Ding F. Anti-inflammatory Activity of a Polypeptide Fraction From in Amyloid β Oligomers Induced Model of Alzheimer's Disease. Frontiers in Pharmacology. 12: 716177. PMID 34456729 DOI: 10.3389/fphar.2021.716177   
2021 Ahn A, Rodger EJ, Motwani J, Gimenez G, Stockwell PA, Parry M, Hersey P, Chatterjee A, Eccles MR. Transcriptional Reprogramming and Constitutive PD-L1 Expression in Melanoma Are Associated with Dedifferentiation and Activation of Interferon and Tumour Necrosis Factor Signalling Pathways. Cancers. 13. PMID 34503064 DOI: 10.3390/cancers13174250   
2021 Sun L, Jiang WW, Wang Y, Yuan YS, Rong Z, Wu J, Fan Y, Lu M, Zhang KZ. Phosphorylated α-synuclein aggregated in Schwann cells exacerbates peripheral neuroinflammation and nerve dysfunction in Parkinson's disease through TLR2/NF-κB pathway. Cell Death Discovery. 7: 289. PMID 34642321 DOI: 10.1038/s41420-021-00676-w   
2021 Assi HH, Wong C, Tipton KA, Mei L, Wong K, Razo J, Chan C, Howng B, Sagert J, Krimm M, Diep L, Jang A, Nguyen MT, Lapuyade N, Singson V, et al. Conditional PD-1/PD-L1 Probody therapeutics induce comparable antitumor immunity but reduced systemic toxicity compared with traditional anti-PD 1/PD-L1 agents. Cancer Immunology Research. PMID 34635485 DOI: 10.1158/2326-6066.CIR-21-0031   
2021 Bai X, Zhang X, Fang R, Wang J, Ma Y, Liu Z, Dong H, Li Q, Ge J, Yu M, Fei J, Sun R, Huang F. Deficiency of leads to accelerated aging and neuroprotection in MPTP-induced Parkinson's disease mice. Aging. 13. PMID 34543233 DOI: 10.18632/aging.203545   
2021 Moon JH, Hong JM, Park SY. Calcineurin Activation by Prion Protein Induces Neurotoxicity via Mitochondrial Reactive Oxygen Species. Oxidative Medicine and Cellular Longevity. 2021: 5572129. PMID 34394828 DOI: 10.1155/2021/5572129   
2021 Chen S, Annesley SJ, Jasim RAF, Fisher PR. The Parkinson's Disease-Associated Protein DJ-1 Protects Cells from AMPK-Dependent Outcomes of Oxidative Stress. Cells. 10. PMID 34440642 DOI: 10.3390/cells10081874   
2021 Sun W, Shen Y, Xiao H, Li H. Resveratrol attenuates rotenone-induced inflammation and oxidative stress via STAT1 and Nrf2/Keap1/SLC7A11 pathway in a microglia cell line. Pathology, Research and Practice. 225: 153576. PMID 34391968 DOI: 10.1016/j.prp.2021.153576   
2021 Xu F, Fei Z, Dai H, Xu J, Fan Q, Shen S, Zhang Y, Ma Q, Chu J, Peng F, Zhou F, Liu Z, Wang C. Mesenchymal Stem Cell-derived Extracellular Vesicles with High PD-L1 Expression for Autoimmune Diseases Treatment. Advanced Materials (Deerfield Beach, Fla.). e2106265. PMID 34613627 DOI: 10.1002/adma.202106265   
2021 SenGupta T, Palikaras K, Esbensen YQ, Konstantinidis G, Galindo FJN, Achanta K, Kassahun H, Stavgiannoudaki I, Bohr VA, Akbari M, Gaare J, Tzoulis C, Tavernarakis N, Nilsen H. Base excision repair causes age-dependent accumulation of single-stranded DNA breaks that contribute to Parkinson disease pathology. Cell Reports. 36: 109668. PMID 34496255 DOI: 10.1016/j.celrep.2021.109668   
2021 Clarke E, Eriksen JG, Barrett S. The effects of PD-1/PD-L1 checkpoint inhibitors on recurrent/metastatic head and neck squamous cell carcinoma: a critical review of the literature and meta-analysis. Acta Oncologica (Stockholm, Sweden). 1-9. PMID 34410881 DOI: 10.1080/0284186X.2021.1964699   
2021 Fang Y, Wang X, Yang D, Lu Y, Wei G, Yu W, Liu X, Zheng Q, Ying J, Hua F. Relieving Cellular Energy Stress in Aging, Neurodegenerative, and Metabolic Diseases, SIRT1 as a Therapeutic and Promising Node. Frontiers in Aging Neuroscience. 13: 738686. PMID 34616289 DOI: 10.3389/fnagi.2021.738686   
2021 Park JM, Han YM, Hahm KB. Rejuvenation of -Associated Atrophic Gastritis Through Concerted Actions of Placenta-Derived Mesenchymal Stem Cells Prevented Gastric Cancer. Frontiers in Pharmacology. 12: 675443. PMID 34483897 DOI: 10.3389/fphar.2021.675443   
2021 Hu J, Wu J, Wan F, Kou L, Yin S, Sun Y, Li Y, Zhou Q, Wang T. Calcitriol Alleviates MPP- and MPTP-Induced Parthanatos Through the VDR/PARP1 Pathway in the Model of Parkinson's Disease. Frontiers in Aging Neuroscience. 13: 657095. PMID 34393753 DOI: 10.3389/fnagi.2021.657095   
2021 Wang JF, Wang YP, Xie J, Zhao ZZ, Gupta S, Guo Y, Jia SH, Parodo J, Marshall JC, Deng XM. Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental mouse model of sepsis. Blood. 138: 806-810. PMID 34473230 DOI: 10.1182/blood.2020009417   
2021 Ma P, Jin X, Fan Z, Wang Z, Yue S, Wu C, Chen S, Wu Y, Chen M, Gu D, Zhang S, Mao R, Fan Y. Super-enhancer receives signals from the extracellular matrix to induce PD-L1-mediated immune evasion integrin/BRAF/TAK1/ERK/ETV4 signaling. Cancer Biology & Medicine. PMID 34623791 DOI: 10.20892/j.issn.2095-3941.2021.0137   
2021 Chen J, Chen Y, Zheng Y, Zhao J, Yu H, Zhu J, Li D. Protective Effects and Mechanisms of Procyanidins on Parkinson's Disease In Vivo and In Vitro. Molecules (Basel, Switzerland). 26. PMID 34577027 DOI: 10.3390/molecules26185558   
2021 Zanardi A, Barbariga M, Conti A, Vegliani F, Curnis F, Alessio M. Oxidized/deamidated-ceruloplasmin dysregulates choroid plexus epithelial cells functionality and barrier properties via RGD-recognizing integrin binding. Neurobiology of Disease. 158: 105474. PMID 34384868 DOI: 10.1016/j.nbd.2021.105474   
2021 Xu PC, Luan Y, Yu SY, Xu J, Coulter DW, Kim SY. Effects of PD-1 blockade on ovarian follicles in a prepubertal female mouse. The Journal of Endocrinology. PMID 34647523 DOI: 10.1530/JOE-21-0209   
2021 O'Connell TJ, Dadafarin S, Jones M, Rodríguez T, Gupta A, Shin E, Moscatello A, Iacob C, Islam H, Tiwari RK, Geliebter J. Androgen Activity Is Associated With PD-L1 Downregulation in Thyroid Cancer. Frontiers in Cell and Developmental Biology. 9: 663130. PMID 34422798 DOI: 10.3389/fcell.2021.663130   
2021 Mondal A, Saha P, Bose D, Chatterjee S, Seth RK, Xiao S, Porter DE, Brooks B, Scott GI, Nagarkatti M, Nagarkatti P, Chatterjee S. Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are NLRP3 and S100B dependent. Toxicology. 152901. PMID 34416350 DOI: 10.1016/j.tox.2021.152901   
2021 Hu X, Lin Z, Wang Z, Zhou Q. Emerging role of PD-L1 modification in cancer immunotherapy. American Journal of Cancer Research. 11: 3832-3840. PMID 34522452   
2021 Avrutsky MI, Troy CM. Caspase-9: A Multimodal Therapeutic Target With Diverse Cellular Expression in Human Disease. Frontiers in Pharmacology. 12: 701301. PMID 34305609 DOI: 10.3389/fphar.2021.701301   
2021 Shen X, Wang Y, Jin Y, Zheng Q, Shen L, Chen Y, Li Y. PD-L1 expression in non-small cell lung cancer: heterogeneity by pathologic types, tissue sampling and metastasis. Journal of Thoracic Disease. 13: 4360-4370. PMID 34422362 DOI: 10.21037/jtd-21-388   
2021 Chen Q, Lu H, Duan C, Zhu X, Zhang Y, Li M, Zhang D. PDCD4 Simultaneously Promotes Microglia Activation via PDCD4-MAPK-NF-κB Positive Loop and Facilitates Neuron Apoptosis During Neuroinflammation. Inflammation. PMID 34613548 DOI: 10.1007/s10753-021-01541-9   
2021 Mazza MC, Beilina A, Roosen DA, Hauser D, Cookson MR. Generation of iPSC line from a Parkinson patient with PARK7 mutation and CRISPR-edited Gibco human episomal iPSC line to mimic PARK7 mutation. Stem Cell Research. 55: 102506. PMID 34419745 DOI: 10.1016/j.scr.2021.102506   
2021 Rueda-Carrasco J, Martin-Bermejo MJ, Pereyra G, Mateo MI, Borroto A, Brosseron F, Kummer MP, Schwartz S, López-Atalaya JP, Alarcon B, Esteve P, Heneka MT, Bovolenta P. SFRP1 modulates astrocyte-to-microglia crosstalk in acute and chronic neuroinflammation. Embo Reports. e51696. PMID 34569685 DOI: 10.15252/embr.202051696