Tsuyoshi Hirota, PhD - Publications

Affiliations: 
Biology University of California, San Diego, La Jolla, CA 
Area:
Circadian Rhythms

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Mosser EA, Chiu CN, Tamai TK, Hirota T, Li S, Hui M, Wang A, Singh C, Giovanni A, Kay SA, Prober DA. Identification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen. Scientific Reports. 9: 12405. PMID 31455847 DOI: 10.1038/s41598-019-48914-7  1
2019 Uehara TN, Mizutani Y, Kuwata K, Hirota T, Sato A, Mizoi J, Takao S, Matsuo H, Suzuki T, Ito S, Saito AN, Nishiwaki-Ohkawa T, Yamaguchi-Shinozaki K, Yoshimura T, Kay SA, et al. Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock. Proceedings of the National Academy of Sciences of the United States of America. PMID 31097584 DOI: 10.1073/pnas.1903357116  1
2019 Oshima T, Niwa Y, Kuwata K, Srivastava A, Hyoda T, Tsuchiya Y, Kumagai M, Tsuyuguchi M, Tamaru T, Sugiyama A, Ono N, Zolboot N, Aikawa Y, Oishi S, Nonami A, ... ... Hirota T, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Science Advances. 5: eaau9060. PMID 30746467 DOI: 10.1126/sciadv.aau9060  1
2019 Lee JW, Hirota T, Ono D, Honma S, Honma KI, Park K, Kay S. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ. Journal of Medicinal Chemistry. PMID 30707835 DOI: 10.1021/acs.jmedchem.8b01541  1
2018 Qu M, Duffy T, Hirota T, Kay SA. Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks. Proceedings of the National Academy of Sciences of the United States of America. PMID 30530698 DOI: 10.1073/pnas.1816411115  1
2016 Zhao X, Hirota T, Han X, Cho H, Chong LW, Lamia K, Liu S, Atkins AR, Banayo E, Liddle C, Yu RT, Yates JR, Kay SA, Downes M, Evans RM. Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation. Cell. 165: 1644-57. PMID 27238018 DOI: 10.1016/j.cell.2016.05.012  1
2015 Lee JW, Hirota T, Kumar A, Kim NJ, Irle S, Kay SA. Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. Chemmedchem. 10: 1489-97. PMID 26174033 DOI: 10.1002/cmdc.201500260  1
2015 Oshima T, Yamanaka I, Kumar A, Yamaguchi J, Nishiwaki-Ohkawa T, Muto K, Kawamura R, Hirota T, Yagita K, Irle S, Kay SA, Yoshimura T, Itami K. C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock. Angewandte Chemie (International Ed. in English). 54: 7193-7. PMID 25960183 DOI: 10.1002/anie.201502942  1
2015 Hirota T, Kay SA. Identification of small-molecule modulators of the circadian clock. Methods in Enzymology. 551: 267-82. PMID 25662461 DOI: 10.1016/bs.mie.2014.10.015  1
2015 Paternoster L, Standl M, Waage J, Baurecht H, Hotze M, Strachan DP, Curtin JA, Bønnelykke K, Tian C, Takahashi A, Esparza-Gordillo J, Alves AC, Thyssen JP, Den Dekker HT, Ferreira MA, ... ... Hirota T, et al. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis Nature Genetics. 47: 1449-1456. DOI: 10.1038/ng.3424  1
2014 Hirano A, Kurabayashi N, Nakagawa T, Shioi G, Todo T, Hirota T, Fukada Y. In vivo role of phosphorylation of cryptochrome 2 in the mouse circadian clock. Molecular and Cellular Biology. 34: 4464-73. PMID 25288642 DOI: 10.1128/MCB.00711-14  1
2014 St John PC, Hirota T, Kay SA, Doyle FJ. Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock. Proceedings of the National Academy of Sciences of the United States of America. 111: 2040-5. PMID 24449901 DOI: 10.1073/pnas.1323618111  1
2013 Tsutsui K, Haraguchi S, Inoue K, Miyabara H, Ubuka T, Hatori M, Hirota T, Fukada Y. New biosynthesis and biological actions of avian neurosteroids. Journal of Experimental Neuroscience. 7: 15-29. PMID 25157204 DOI: 10.4137/JEN.S11148  1
2013 Tsutsui K, Haraguchi S, Hatori M, Hirota T, Fukada Y. Biosynthesis and biological actions of pineal neurosteroids in domestic birds. Neuroendocrinology. 98: 97-105. PMID 23797037 DOI: 10.1159/000353782  1
2013 Weger M, Weger BD, Diotel N, Rastegar S, Hirota T, Kay SA, Strähle U, Dickmeis T. Real-time in vivo monitoring of circadian E-box enhancer activity: a robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock. Developmental Biology. 380: 259-73. PMID 23665472 DOI: 10.1016/j.ydbio.2013.04.035  1
2012 Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T, Welsh DK, Brenner DA, Doyle FJ, Schultz PG, Kay SA. Identification of small molecule activators of cryptochrome. Science (New York, N.Y.). 337: 1094-7. PMID 22798407 DOI: 10.1126/science.1223710  1
2011 Lee JW, Hirota T, Peters EC, Garcia M, Gonzalez R, Cho CY, Wu X, Schultz PG, Kay SA. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angewandte Chemie (International Ed. in English). 50: 10608-11. PMID 21954091 DOI: 10.1002/anie.201103915  1
2011 Iyengar PV, Hirota T, Hirose S, Nakamura N. Membrane-associated RING-CH 10 (MARCH10 protein) is a microtubule-associated E3 ubiquitin ligase of the spermatid flagella. The Journal of Biological Chemistry. 286: 39082-90. PMID 21937444 DOI: 10.1074/jbc.M111.256875  1
2011 Hatori M, Hirota T, Iitsuka M, Kurabayashi N, Haraguchi S, Kokame K, Sato R, Nakai A, Miyata T, Tsutsui K, Fukada Y. Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1, and heat shock factor pathways. Proceedings of the National Academy of Sciences of the United States of America. 108: 4864-9. PMID 21383147 DOI: 10.1073/pnas.1015959108  1
2010 Hirota T, Lee JW, Lewis WG, Zhang EE, Breton G, Liu X, Garcia M, Peters EC, Etchegaray JP, Traver D, Schultz PG, Kay SA. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. Plos Biology. 8: e1000559. PMID 21179498 DOI: 10.1371/journal.pbio.1000559  1
2010 Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner DA, Montminy M, Kay SA. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nature Medicine. 16: 1152-6. PMID 20852621 DOI: 10.1038/nm.2214  1
2010 Kurabayashi N, Hirota T, Sakai M, Sanada K, Fukada Y. DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping. Molecular and Cellular Biology. 30: 1757-68. PMID 20123978 DOI: 10.1128/MCB.01047-09  1
2010 Hirota T, Kon N, Itagaki T, Hoshina N, Okano T, Fukada Y. Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 15: 111-21. PMID 20070857 DOI: 10.1111/j.1365-2443.2009.01371.x  1
2009 Hirota T, Kay SA. High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms. Chemistry & Biology. 16: 921-7. PMID 19778719 DOI: 10.1016/j.chembiol.2009.09.002  1
2009 Zhang EE, Liu AC, Hirota T, Miraglia LJ, Welch G, Pongsawakul PY, Liu X, Atwood A, Huss JW, Janes J, Su AI, Hogenesch JB, Kay SA. A genome-wide RNAi screen for modifiers of the circadian clock in human cells. Cell. 139: 199-210. PMID 19765810 DOI: 10.1016/j.cell.2009.08.031  1
2008 Hirota T, Lewis WG, Liu AC, Lee JW, Schultz PG, Kay SA. A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta. Proceedings of the National Academy of Sciences of the United States of America. 105: 20746-51. PMID 19104043 DOI: 10.1073/pnas.0811410106  1
2008 Kon N, Hirota T, Kawamoto T, Kato Y, Tsubota T, Fukada Y. Activation of TGF-beta/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts. Nature Cell Biology. 10: 1463-9. PMID 19029909 DOI: 10.1038/ncb1806  1
2007 Tsuji T, Hirota T, Takemori N, Komori N, Yoshitane H, Fukuda M, Matsumoto H, Fukada Y. Circadian proteomics of the mouse retina. Proteomics. 7: 3500-8. PMID 17726681 DOI: 10.1002/pmic.200700272  1
2006 Kurabayashi N, Hirota T, Harada Y, Sakai M, Fukada Y. Phosphorylation of mCRY2 at Ser557 in the hypothalamic suprachiasmatic nucleus of the mouse. Chronobiology International. 23: 129-34. PMID 16687286 DOI: 10.1080/07420520500464478  1
2005 Harada Y, Sakai M, Kurabayashi N, Hirota T, Fukada Y. Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3 beta. The Journal of Biological Chemistry. 280: 31714-21. PMID 15980066 DOI: 10.1074/jbc.M506225200  1
2004 Hirota T, Fukada Y. Resetting mechanism of central and peripheral circadian clocks in mammals. Zoological Science. 21: 359-68. PMID 15118222 DOI: 10.2108/zsj.21.359  1
2003 Hayashi Y, Sanada K, Hirota T, Shimizu F, Fukada Y. p38 mitogen-activated protein kinase regulates oscillation of chick pineal circadian clock. The Journal of Biological Chemistry. 278: 25166-71. PMID 12719413 DOI: 10.1074/jbc.M212726200  1
2002 Hirota T, Okano T, Kokame K, Shirotani-Ikejima H, Miyata T, Fukada Y. Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured Rat-1 fibroblasts. The Journal of Biological Chemistry. 277: 44244-51. PMID 12213820 DOI: 10.1074/jbc.M206233200  1
2001 Okano T, Yamamoto K, Okano K, Hirota T, Kasahara T, Sasaki M, Takanaka Y, Fukada Y. Chicken pineal clock genes: Implication of BMAL2 as a bidirectional regulator in circadian clock oscillation Genes to Cells. 6: 825-836. PMID 11554928 DOI: 10.1046/j.1365-2443.2001.00462.x  1
2001 Hirota T, Kagiwada S, Kasahara T, Okano T, Murata M, Fukada Y. Effect of brefeldin A on melatonin secretion of chick pineal cells Journal of Biochemistry. 129: 51-59. PMID 11134957  1
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