Year |
Citation |
Score |
2022 |
Yagi M, Miller S, Nagai Y, Inuki S, Sato A, Hirota T. A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins. F1000research. 11: 1016. PMID 36226040 DOI: 10.12688/f1000research.124658.1 |
0.498 |
|
2022 |
Miller S, Kesherwani M, Chan P, Nagai Y, Yagi M, Cope J, Tama F, Kay SA, Hirota T. CRY2 isoform selectivity of a circadian clock modulator with antiglioblastoma efficacy. Proceedings of the National Academy of Sciences of the United States of America. 119: e2203936119. PMID 36161947 DOI: 10.1073/pnas.2203936119 |
0.641 |
|
2022 |
Hatori M, Hirota T. Cell-Based Phenotypic Screens to Discover Circadian Clock-Modulating Compounds. Methods in Molecular Biology (Clifton, N.J.). 2482: 95-104. PMID 35610421 DOI: 10.1007/978-1-0716-2249-0_6 |
0.522 |
|
2022 |
Miller S, Hirota T. Structural and Chemical Biology Approaches Reveal Isoform-Selective Mechanisms of Ligand Interactions in Mammalian Cryptochromes. Frontiers in Physiology. 13: 837280. PMID 35153842 DOI: 10.3389/fphys.2022.837280 |
0.352 |
|
2022 |
Uehara TN, Nonoyama T, Taki K, Kuwata K, Sato A, Fujimoto KJ, Hirota T, Matsuo H, Maeda AE, Ono A, Takahara TT, Tsutsui H, Suzuki T, Yanai T, Kay SA, et al. Phosphorylation of RNA Polymerase II by CDKC;2 Maintains the Arabidopsis Circadian Clock Period. Plant & Cell Physiology. PMID 35086143 DOI: 10.1093/pcp/pcac011 |
0.668 |
|
2021 |
Zhang M, Kobayashi K, Atsumi H, Katada Y, Nakane Y, Chen J, Nagano R, Kadofusa N, Nishiwaki-Ohkawa T, Kon N, Hirota T, Sato A, Makino T, Yoshimura T. Modulation of circadian clock by crude drug extracts used in Japanese Kampo medicine. Scientific Reports. 11: 21038. PMID 34702865 DOI: 10.1038/s41598-021-00499-w |
0.385 |
|
2021 |
Iida M, Nakane Y, Yoshimura T, Hirota T. Effects of Cryptochrome-modulating compounds on circadian behavioral rhythms in zebrafish. Journal of Biochemistry. PMID 34528676 DOI: 10.1093/jb/mvab096 |
0.444 |
|
2021 |
Kolarski D, Miró-Vinyals C, Sugiyama A, Srivastava A, Ono D, Nagai Y, Iida M, Itami K, Tama F, Szymanski W, Hirota T, Feringa BL. Reversible modulation of circadian time with chronophotopharmacology. Nature Communications. 12: 3164. PMID 34039965 DOI: 10.1038/s41467-021-23301-x |
0.833 |
|
2021 |
Kolarski D, Sugiyama A, Rodat T, Schulte A, Peifer C, Itami K, Hirota T, Feringa BL, Szymanski W. Reductive stability evaluation of 6-azopurine photoswitches for the regulation of CKIα activity and circadian rhythms. Organic & Biomolecular Chemistry. PMID 33634812 DOI: 10.1039/d1ob00014d |
0.819 |
|
2021 |
Kolarski D, Miller S, Oshima T, Nagai Y, Aoki Y, Kobauri P, Srivastava A, Sugiyama A, Amaike K, Sato A, Tama F, Szymanski W, Feringa BL, Itami K, Hirota T. Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock. Journal of the American Chemical Society. PMID 33464888 DOI: 10.1021/jacs.0c12280 |
0.829 |
|
2020 |
Borgo C, D'Amore C, Cesaro L, Itami K, Hirota T, Salvi M, Pinna LA. A N-terminally deleted form of the CK2α' catalytic subunit is sufficient to support cell viability. Biochemical and Biophysical Research Communications. PMID 32800562 DOI: 10.1016/J.Bbrc.2020.07.112 |
0.373 |
|
2020 |
D'Amore C, Moro E, Borgo C, Itami K, Hirota T, Pinna LA, Salvi M. "JANUS" EFFICACY OF CX-5011: CK2 INHIBITION AND METHUOSIS INDUCTION BY INDEPENDENT MECHANISMS. Biochimica Et Biophysica Acta. Molecular Cell Research. 118807. PMID 32745724 DOI: 10.1016/J.Bbamcr.2020.118807 |
0.382 |
|
2020 |
Miller S, Aikawa Y, Sugiyama A, Nagai Y, Hara A, Oshima T, Amaike K, Kay SA, Itami K, Hirota T. An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals. Cell Chemical Biology. PMID 32502390 DOI: 10.1016/J.Chembiol.2020.05.008 |
0.725 |
|
2020 |
Miller S, Son YL, Aikawa Y, Makino E, Nagai Y, Srivastava A, Oshima T, Sugiyama A, Hara A, Abe K, Hirata K, Oishi S, Hagihara S, Sato A, Tama F, ... ... Hirota T, et al. Isoform-selective regulation of mammalian cryptochromes. Nature Chemical Biology. PMID 32231341 DOI: 10.1038/s41589-020-0505-1 |
0.613 |
|
2020 |
Fribourgh JL, Srivastava A, Sandate CR, Michael AK, Hsu PL, Rakers C, Nguyen LT, Torgrimson MR, Parico GCG, Tripathi S, Zheng N, Lander GC, Hirota T, Tama F, Partch CL. Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. Elife. 9. PMID 32101164 DOI: 10.7554/Elife.55275 |
0.477 |
|
2020 |
Miller S, Hirota T. Pharmacological interventions to circadian clocks and their molecular bases. Journal of Molecular Biology. PMID 31931005 DOI: 10.1016/J.Jmb.2020.01.003 |
0.566 |
|
2020 |
Fribourgh JL, Srivastava A, Sandate CR, Michael AK, Hsu PL, Rakers C, Nguyen LT, Torgrimson MR, Parico GCG, Tripathi S, Zheng N, Lander GC, Hirota T, Tama F, Partch CL. Author response: Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing Elife. DOI: 10.7554/Elife.55275.Sa2 |
0.413 |
|
2020 |
Miller S, Son YL, Aikawa Y, Makino E, Nagai Y, Srivastava A, Oshima T, Sugiyama A, Hara A, Abe K, Hirata K, Oishi S, Hagihara S, Sato A, Tama F, ... ... Hirota T, et al. Isoform selective regulation of mammalian Cryptochromes Nature Chemical Biology. 16: 676-685. DOI: 10.2210/Pdb6Kx7/Pdb |
0.67 |
|
2020 |
Hirota T. Small molecule modulators of the circadian clock function Proceedings For Annual Meeting of the Japanese Pharmacological Society. 93: 1-S12-3. DOI: 10.1254/jpssuppl.93.0_1-s12-3 |
0.394 |
|
2020 |
Amaike K, Oshima T, Skoulding NS, Toyama Y, Hirota T, Itami K. Small Molecules Modulating Mammalian Biological Clocks: Exciting New Opportunities for Synthetic Chemistry Chem. 6: 2186-2198. DOI: 10.1016/J.Chempr.2020.08.011 |
0.515 |
|
2019 |
Kolarski D, Sugiyama A, Breton G, Rakers C, Ono D, Schulte A, Tama F, Itami K, Szymanski W, Hirota T, Feringa BL. Controlling the Circadian Clock with High Temporal Resolution through Photodosing. Journal of the American Chemical Society. PMID 31509406 DOI: 10.1021/Jacs.9B05445 |
0.809 |
|
2019 |
Mosser EA, Chiu CN, Tamai TK, Hirota T, Li S, Hui M, Wang A, Singh C, Giovanni A, Kay SA, Prober DA. Identification of pathways that regulate circadian rhythms using a larval zebrafish small molecule screen. Scientific Reports. 9: 12405. PMID 31455847 DOI: 10.1038/S41598-019-48914-7 |
0.701 |
|
2019 |
Uehara TN, Mizutani Y, Kuwata K, Hirota T, Sato A, Mizoi J, Takao S, Matsuo H, Suzuki T, Ito S, Saito AN, Nishiwaki-Ohkawa T, Yamaguchi-Shinozaki K, Yoshimura T, Kay SA, et al. Casein kinase 1 family regulates PRR5 and TOC1 in the Arabidopsis circadian clock. Proceedings of the National Academy of Sciences of the United States of America. PMID 31097584 DOI: 10.1073/Pnas.1903357116 |
0.711 |
|
2019 |
Oshima T, Niwa Y, Kuwata K, Srivastava A, Hyoda T, Tsuchiya Y, Kumagai M, Tsuyuguchi M, Tamaru T, Sugiyama A, Ono N, Zolboot N, Aikawa Y, Oishi S, Nonami A, ... ... Hirota T, et al. Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth. Science Advances. 5: eaau9060. PMID 30746467 DOI: 10.1126/Sciadv.Aau9060 |
0.685 |
|
2019 |
Lee JW, Hirota T, Ono D, Honma S, Honma KI, Park K, Kay S. Chemical Control of Mammalian Circadian Behavior through Dual Inhibition of Casein Kinase Iα and δ. Journal of Medicinal Chemistry. PMID 30707835 DOI: 10.1021/Acs.Jmedchem.8B01541 |
0.701 |
|
2018 |
Qu M, Duffy T, Hirota T, Kay SA. Nuclear receptor HNF4A transrepresses CLOCK:BMAL1 and modulates tissue-specific circadian networks. Proceedings of the National Academy of Sciences of the United States of America. PMID 30530698 DOI: 10.1073/Pnas.1816411115 |
0.691 |
|
2017 |
Hatori M, Gronfier C, Van Gelder RN, Bernstein PS, Carreras J, Panda S, Marks F, Sliney D, Hunt CE, Hirota T, Furukawa T, Tsubota K. Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies. Npj Aging and Mechanisms of Disease. 3: 9. PMID 28649427 DOI: 10.1038/s41514-017-0010-2 |
0.551 |
|
2016 |
Zhao X, Hirota T, Han X, Cho H, Chong LW, Lamia K, Liu S, Atkins AR, Banayo E, Liddle C, Yu RT, Yates JR, Kay SA, Downes M, Evans RM. Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation. Cell. 165: 1644-57. PMID 27238018 DOI: 10.1016/J.Cell.2016.05.012 |
0.724 |
|
2015 |
Lee JW, Hirota T, Kumar A, Kim NJ, Irle S, Kay SA. Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock. Chemmedchem. 10: 1489-97. PMID 26174033 DOI: 10.1002/Cmdc.201500260 |
0.639 |
|
2015 |
Oshima T, Yamanaka I, Kumar A, Yamaguchi J, Nishiwaki-Ohkawa T, Muto K, Kawamura R, Hirota T, Yagita K, Irle S, Kay SA, Yoshimura T, Itami K. C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock. Angewandte Chemie (International Ed. in English). 54: 7193-7. PMID 25960183 DOI: 10.1002/Anie.201502942 |
0.655 |
|
2015 |
Hirota T, Kay SA. Identification of small-molecule modulators of the circadian clock. Methods in Enzymology. 551: 267-82. PMID 25662461 DOI: 10.1016/Bs.Mie.2014.10.015 |
0.673 |
|
2015 |
Lee JW, Hirota T, Kumar A, Kim N, Irle S, Kay SA. Cover Picture: Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock (ChemMedChem 9/2015) Chemmedchem. 10: 1449-1449. DOI: 10.1002/Cmdc.201500345 |
0.627 |
|
2015 |
Oshima T, Yamanaka I, Kumar A, Yamaguchi J, Nishiwaki-Ohkawa T, Muto K, Kawamura R, Hirota T, Yagita K, Irle S, Kay SA, Yoshimura T, Itami K. Back Cover: CH Activation Generates Period-Shortening Molecules That Target Cryptochrome in the Mammalian Circadian Clock (Angew. Chem. Int. Ed. 24/2015) Angewandte Chemie International Edition. 54: 7200-7200. DOI: 10.1002/Anie.201504172 |
0.648 |
|
2015 |
Oshima T, Yamanaka I, Kumar A, Yamaguchi J, Nishiwaki-Ohkawa T, Muto K, Kawamura R, Hirota T, Yagita K, Irle S, Kay SA, Yoshimura T, Itami K. Rücktitelbild: CH Activation Generates Period-Shortening Molecules That Target Cryptochrome in the Mammalian Circadian Clock (Angew. Chem. 24/2015) Angewandte Chemie. 127: 7306-7306. DOI: 10.1002/Ange.201504172 |
0.654 |
|
2014 |
Hirano A, Kurabayashi N, Nakagawa T, Shioi G, Todo T, Hirota T, Fukada Y. In vivo role of phosphorylation of cryptochrome 2 in the mouse circadian clock. Molecular and Cellular Biology. 34: 4464-73. PMID 25288642 DOI: 10.1128/Mcb.00711-14 |
0.517 |
|
2014 |
St John PC, Hirota T, Kay SA, Doyle FJ. Spatiotemporal separation of PER and CRY posttranslational regulation in the mammalian circadian clock. Proceedings of the National Academy of Sciences of the United States of America. 111: 2040-5. PMID 24449901 DOI: 10.1073/Pnas.1323618111 |
0.732 |
|
2013 |
Tsutsui K, Haraguchi S, Inoue K, Miyabara H, Ubuka T, Hatori M, Hirota T, Fukada Y. New biosynthesis and biological actions of avian neurosteroids. Journal of Experimental Neuroscience. 7: 15-29. PMID 25157204 DOI: 10.4137/Jen.S11148 |
0.36 |
|
2013 |
Tsutsui K, Haraguchi S, Hatori M, Hirota T, Fukada Y. Biosynthesis and biological actions of pineal neurosteroids in domestic birds. Neuroendocrinology. 98: 97-105. PMID 23797037 DOI: 10.1159/000353782 |
0.38 |
|
2013 |
Weger M, Weger BD, Diotel N, Rastegar S, Hirota T, Kay SA, Strähle U, Dickmeis T. Real-time in vivo monitoring of circadian E-box enhancer activity: a robust and sensitive zebrafish reporter line for developmental, chemical and neural biology of the circadian clock. Developmental Biology. 380: 259-73. PMID 23665472 DOI: 10.1016/J.Ydbio.2013.04.035 |
0.697 |
|
2012 |
Hirota T, Lee JW, St John PC, Sawa M, Iwaisako K, Noguchi T, Pongsawakul PY, Sonntag T, Welsh DK, Brenner DA, Doyle FJ, Schultz PG, Kay SA. Identification of small molecule activators of cryptochrome. Science (New York, N.Y.). 337: 1094-7. PMID 22798407 DOI: 10.1126/Science.1223710 |
0.785 |
|
2011 |
Lee JW, Hirota T, Peters EC, Garcia M, Gonzalez R, Cho CY, Wu X, Schultz PG, Kay SA. A small molecule modulates circadian rhythms through phosphorylation of the period protein. Angewandte Chemie (International Ed. in English). 50: 10608-11. PMID 21954091 DOI: 10.1002/Anie.201103915 |
0.694 |
|
2011 |
Iyengar PV, Hirota T, Hirose S, Nakamura N. Membrane-associated RING-CH 10 (MARCH10 protein) is a microtubule-associated E3 ubiquitin ligase of the spermatid flagella. The Journal of Biological Chemistry. 286: 39082-90. PMID 21937444 DOI: 10.1074/Jbc.M111.256875 |
0.343 |
|
2011 |
Hatori M, Hirota T, Iitsuka M, Kurabayashi N, Haraguchi S, Kokame K, Sato R, Nakai A, Miyata T, Tsutsui K, Fukada Y. Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1, and heat shock factor pathways. Proceedings of the National Academy of Sciences of the United States of America. 108: 4864-9. PMID 21383147 DOI: 10.1073/Pnas.1015959108 |
0.53 |
|
2010 |
Hirota T, Lee JW, Lewis WG, Zhang EE, Breton G, Liu X, Garcia M, Peters EC, Etchegaray JP, Traver D, Schultz PG, Kay SA. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase. Plos Biology. 8: e1000559. PMID 21179498 DOI: 10.1371/Journal.Pbio.1000559 |
0.854 |
|
2010 |
Zhang EE, Liu Y, Dentin R, Pongsawakul PY, Liu AC, Hirota T, Nusinow DA, Sun X, Landais S, Kodama Y, Brenner DA, Montminy M, Kay SA. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Nature Medicine. 16: 1152-6. PMID 20852621 DOI: 10.1038/Nm.2214 |
0.734 |
|
2010 |
Kurabayashi N, Hirota T, Sakai M, Sanada K, Fukada Y. DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping. Molecular and Cellular Biology. 30: 1757-68. PMID 20123978 DOI: 10.1128/Mcb.01047-09 |
0.482 |
|
2010 |
Hirota T, Kon N, Itagaki T, Hoshina N, Okano T, Fukada Y. Transcriptional repressor TIEG1 regulates Bmal1 gene through GC box and controls circadian clockwork. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 15: 111-21. PMID 20070857 DOI: 10.1111/J.1365-2443.2009.01371.X |
0.564 |
|
2009 |
Hirota T, Kay SA. High-throughput screening and chemical biology: new approaches for understanding circadian clock mechanisms. Chemistry & Biology. 16: 921-7. PMID 19778719 DOI: 10.1016/J.Chembiol.2009.09.002 |
0.75 |
|
2009 |
Zhang EE, Liu AC, Hirota T, Miraglia LJ, Welch G, Pongsawakul PY, Liu X, Atwood A, Huss JW, Janes J, Su AI, Hogenesch JB, Kay SA. A genome-wide RNAi screen for modifiers of the circadian clock in human cells. Cell. 139: 199-210. PMID 19765810 DOI: 10.1016/J.Cell.2009.08.031 |
0.684 |
|
2008 |
Hirota T, Lewis WG, Liu AC, Lee JW, Schultz PG, Kay SA. A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta. Proceedings of the National Academy of Sciences of the United States of America. 105: 20746-51. PMID 19104043 DOI: 10.1073/Pnas.0811410106 |
0.793 |
|
2008 |
Kon N, Hirota T, Kawamoto T, Kato Y, Tsubota T, Fukada Y. Activation of TGF-beta/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts. Nature Cell Biology. 10: 1463-9. PMID 19029909 DOI: 10.1038/Ncb1806 |
0.483 |
|
2007 |
Tsuji T, Hirota T, Takemori N, Komori N, Yoshitane H, Fukuda M, Matsumoto H, Fukada Y. Circadian proteomics of the mouse retina. Proteomics. 7: 3500-8. PMID 17726681 DOI: 10.1002/Pmic.200700272 |
0.455 |
|
2006 |
Kurabayashi N, Hirota T, Harada Y, Sakai M, Fukada Y. Phosphorylation of mCRY2 at Ser557 in the hypothalamic suprachiasmatic nucleus of the mouse. Chronobiology International. 23: 129-34. PMID 16687286 DOI: 10.1080/07420520500464478 |
0.404 |
|
2005 |
Harada Y, Sakai M, Kurabayashi N, Hirota T, Fukada Y. Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3 beta. The Journal of Biological Chemistry. 280: 31714-21. PMID 15980066 DOI: 10.1074/Jbc.M506225200 |
0.413 |
|
2004 |
Hirota T, Fukada Y. Resetting mechanism of central and peripheral circadian clocks in mammals. Zoological Science. 21: 359-68. PMID 15118222 DOI: 10.2108/Zsj.21.359 |
0.583 |
|
2003 |
Hayashi Y, Sanada K, Hirota T, Shimizu F, Fukada Y. p38 mitogen-activated protein kinase regulates oscillation of chick pineal circadian clock. The Journal of Biological Chemistry. 278: 25166-71. PMID 12719413 DOI: 10.1074/Jbc.M212726200 |
0.495 |
|
2002 |
Hirota T, Okano T, Kokame K, Shirotani-Ikejima H, Miyata T, Fukada Y. Glucose down-regulates Per1 and Per2 mRNA levels and induces circadian gene expression in cultured Rat-1 fibroblasts. The Journal of Biological Chemistry. 277: 44244-51. PMID 12213820 DOI: 10.1074/Jbc.M206233200 |
0.514 |
|
2001 |
Okano T, Yamamoto K, Okano K, Hirota T, Kasahara T, Sasaki M, Takanaka Y, Fukada Y. Chicken pineal clock genes: Implication of BMAL2 as a bidirectional regulator in circadian clock oscillation Genes to Cells. 6: 825-836. PMID 11554928 DOI: 10.1046/J.1365-2443.2001.00462.X |
0.58 |
|
2001 |
Hirota T, Kagiwada S, Kasahara T, Okano T, Murata M, Fukada Y. Effect of brefeldin A on melatonin secretion of chick pineal cells Journal of Biochemistry. 129: 51-59. PMID 11134957 DOI: 10.1093/Oxfordjournals.Jbchem.A002836 |
0.452 |
|
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