Rebecca J. Chan, MD/PhD - Publications

Affiliations: 
Pediatric  Indiana University School of Medicine, Indianapolis, IN, United States 
Area:
Pediatric Medicine, Noonan Syndrome

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Deng L, Richine BM, Virts EL, Jideonwo-Auman VN, Chan RJ, Kapur R. Rapid development of myeloproliferative neoplasm in mice withmutation and haploinsufficient for. Oncotarget. 9: 6055-6061. PMID 29464054 DOI: 10.18632/oncotarget.23680  0.4
2017 Clinkenbeard EL, Hanudel MR, Stayrook KR, Appaiah HN, Farrow EG, Cass TA, Summers LJ, Ip CS, Hum JM, Thomas JC, Ivan M, Richine BM, Chan RJ, Clemens TL, Schipani E, et al. Erythropoietin stimulates murine and human Fibroblast growth factor-23, revealing novel roles for bone and bone marrow. Haematologica. PMID 28818868 DOI: 10.3324/haematol.2017.167882  0.4
2016 Garringer HJ, Irimia JM, Li W, Goodwin CB, Richine B, Acton A, Chan RJ, Peacock M, Muhoberac BB, Ghetti B, Vidal R. Effect of Systemic Iron Overload and a Chelation Therapy in a Mouse Model of the Neurodegenerative Disease Hereditary Ferritinopathy. Plos One. 11: e0161341. PMID 27574973 DOI: 10.1371/journal.pone.0161341  0.4
2016 Li XJ, Deng L, Brandt SL, Goodwin CB, Ma P, Yang Z, Mali RS, Liu Z, Kapur R, Serezani CH, Chan RJ. Role of p85α in neutrophil extra- and intracellular reactive oxygen species generation. Oncotarget. PMID 27049833 DOI: 10.18632/oncotarget.8500  0.8
2015 Chen L, Chen W, Mysliwski M, Serio J, Ropa J, Abulwerdi FA, Chan RJ, Patel JP, Tallman MS, Paietta E, Melnick A, Levine RL, Abdel-Wahab O, Nikolovska-Coleska Z, Muntean AG. Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition. Leukemia. 29: 1290-300. PMID 25650089 DOI: 10.1038/leu.2015.18  0.8
2015 Li W, Garringer HJ, Goodwin CB, Richine B, Acton A, VanDuyn N, Muhoberac BB, Irimia-Dominguez J, Chan RJ, Peacock M, Nass R, Ghetti B, Vidal R. Systemic and cerebral iron homeostasis in ferritin knock-out mice. Plos One. 10: e0117435. PMID 25629408 DOI: 10.1371/journal.pone.0117435  0.8
2015 Kim H, Huang L, Critser PJ, Yang Z, Chan RJ, Wang L, Carlesso N, Voytik-Harbin SL, Bernstein ID, Yoder MC. Notch ligand Delta-like 1 promotes in vivo vasculogenesis in human cord blood-derived endothelial colony forming cells. Cytotherapy. 17: 579-92. PMID 25559145 DOI: 10.1016/j.jcyt.2014.12.003  0.8
2015 Li XJ, Goodwin CB, Nabinger SC, Richine BM, Yang Z, Hanenberg H, Ohnishi H, Matozaki T, Feng GS, Chan RJ. Protein-tyrosine phosphatase Shp2 positively regulates macrophage oxidative burst. The Journal of Biological Chemistry. 290: 3894-909. PMID 25538234 DOI: 10.1074/jbc.M114.614057  0.8
2014 Chatterjee A, Ghosh J, Ramdas B, Mali RS, Martin H, Kobayashi M, Vemula S, Canela VH, Waskow ER, Visconte V, Tiu RV, Smith CC, Shah N, Bunting KD, Boswell HS, ... ... Chan RJ, et al. Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis. Cell Reports. 9: 1333-48. PMID 25456130 DOI: 10.1016/j.celrep.2014.10.039  0.8
2014 Zeng LF, Zhang RY, Yu ZH, Li S, Wu L, Gunawan AM, Lane BS, Mali RS, Li X, Chan RJ, Kapur R, Wells CD, Zhang ZY. Therapeutic potential of targeting the oncogenic SHP2 phosphatase. Journal of Medicinal Chemistry. 57: 6594-609. PMID 25003231 DOI: 10.1021/jm5006176  0.8
2014 Goodwin CB, Li XJ, Mali RS, Chan G, Kang M, Liu Z, Vanhaesebroeck B, Neel BG, Loh ML, Lannutti BJ, Kapur R, Chan RJ. PI3K p110δ uniquely promotes gain-of-function Shp2-induced GM-CSF hypersensitivity in a model of JMML. Blood. 123: 2838-42. PMID 24553178 DOI: 10.1182/blood-2013-10-535104  0.8
2013 Chan RJ, Yoder MC. JMML patient-derived iPSCs induce new hypotheses. Blood. 121: 4815-7. PMID 23766458 DOI: 10.1182/blood-2013-05-500090  0.8
2013 Sutton TA, Hato T, Mai E, Yoshimoto M, Kuehl S, Anderson M, Mang H, Plotkin Z, Chan RJ, Dagher PC. p53 is renoprotective after ischemic kidney injury by reducing inflammation. Journal of the American Society of Nephrology : Jasn. 24: 113-24. PMID 23222126 DOI: 10.1681/ASN.2012050469  0.8
2013 Nabinger SC, Li XJ, Ramdas B, He Y, Zhang X, Zeng L, Richine B, Bowling JD, Fukuda S, Goenka S, Liu Z, Feng GS, Yu M, Sandusky GE, Boswell HS, ... ... Chan RJ, et al. The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo. Leukemia. 27: 398-408. PMID 23103841 DOI: 10.1038/leu.2012.308  0.8
2013 Broxmeyer HE, Etienne-Julan M, Gotoh A, Braun SE, Lu L, Cooper S, Feng GS, Li XJ, Chan RJ. Hematopoietic colony formation from human growth factor-dependent TF1 cells and human cord blood myeloid progenitor cells depends on SHP2 phosphatase function. Stem Cells and Development. 22: 998-1006. PMID 23082805 DOI: 10.1089/scd.2012.0478  0.8
2012 Mali RS, Ma P, Zeng LF, Martin H, Ramdas B, He Y, Sims E, Nabinger S, Ghosh J, Sharma N, Munugalavadla V, Chatterjee A, Li S, Sandusky G, Craig AW, ... ... Chan RJ, et al. Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT. Blood. 120: 2669-78. PMID 22806893 DOI: 10.1182/blood-2011-08-375873  0.8
2012 Nabinger SC, Chan RJ. Shp2 function in hematopoietic stem cell biology and leukemogenesis. Current Opinion in Hematology. 19: 273-9. PMID 22504523 DOI: 10.1097/MOH.0b013e328353c6bf  0.8
2012 Goodwin CB, Yang Z, Yin F, Yu M, Chan RJ. Genetic disruption of the PI3K regulatory subunits, p85α, p55α, and p50α, normalizes mutant PTPN11-induced hypersensitivity to GM-CSF. Haematologica. 97: 1042-7. PMID 22315502 DOI: 10.3324/haematol.2011.046896  0.8
2011 Farrow EG, Yu X, Summers LJ, Davis SI, Fleet JC, Allen MR, Robling AG, Stayrook KR, Jideonwo V, Magers MJ, Garringer HJ, Vidal R, Chan RJ, Goodwin CB, Hui SL, et al. Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice. Proceedings of the National Academy of Sciences of the United States of America. 108: E1146-55. PMID 22006328 DOI: 10.1073/pnas.1110905108  0.8
2011 Mali RS, Ramdas B, Ma P, Shi J, Munugalavadla V, Sims E, Wei L, Vemula S, Nabinger SC, Goodwin CB, Chan RJ, Traina F, Visconte V, Tiu RV, Lewis TA, et al. Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL. Cancer Cell. 20: 357-69. PMID 21907926 DOI: 10.1016/j.ccr.2011.07.016  0.8
2011 Ma P, Mali RS, Munugalavadla V, Krishnan S, Ramdas B, Sims E, Martin H, Ghosh J, Li S, Chan RJ, Krystal G, Craig AW, Takemoto C, Kapur R. The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor. Blood. 118: 3459-69. PMID 21791431 DOI: 10.1182/blood-2011-04-351809  0.8
2011 Chen M, Burgin S, Staser K, He Y, Li X, Robinson M, Jiang L, Chan RJ, Ingram D, Clapp DW. Kinase suppressor of Ras (KSR1) modulates multiple kit-ligand-dependent mast cell functions. Experimental Hematology. 39: 969-76. PMID 21726514 DOI: 10.1016/j.exphem.2011.06.009  0.8
2011 Yang Z, Chen M, Sitarski SA, Saadatzadeh T, Yin F, Yu M, Yang FC, Chan RJ. Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K. Leukemia Research. 35: 961-4. PMID 21555152 DOI: 10.1016/j.leukres.2011.04.003  0.8
2011 Cai S, Wang H, Bailey B, Ernstberger A, Juliar BE, Sinn AL, Chan RJ, Jones DR, Mayo LD, Baluyut AR, Goebel WS, Pollok KE. Humanized bone marrow mouse model as a preclinical tool to assess therapy-mediated hematotoxicity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 2195-206. PMID 21487065 DOI: 10.1158/1078-0432.CCR-10-1959  0.8
2011 Sayar H, Chan RJ, Orschell CM, Chan EM, Yu Z, Hood D, Plett A, Yang Z, Hui CL, Nabinger SC, Kohlbacher KJ, West ES, Walter A, Sampson C, Wu J, et al. Thrice weekly azacitidine does not improve hematological responses in lower-risk myelodysplastic syndromes: a study of the Hoosier Oncology Group. Leukemia Research. 35: 1108-10. PMID 21420732 DOI: 10.1016/j.leukres.2011.02.025  0.8
2011 Kondo T, Matsuoka AJ, Shimomura A, Koehler KR, Chan RJ, Miller JM, Srour EF, Hashino E. Wnt signaling promotes neuronal differentiation from mesenchymal stem cells through activation of Tlx3. Stem Cells (Dayton, Ohio). 29: 836-46. PMID 21374761 DOI: 10.1002/stem.624  0.8
2011 Liu S, Yu Z, Yu X, Huang SX, Luo Y, Wu L, Shen W, Yang Z, Wang L, Gunawan AM, Chan RJ, Shen B, Zhang ZY. SHP2 is a target of the immunosuppressant tautomycetin. Chemistry & Biology. 18: 101-10. PMID 21276943 DOI: 10.1016/j.chembiol.2010.10.015  0.8
2011 Stevenson DA, Schwarz EL, Carey JC, Viskochil DH, Hanson H, Bauer S, Weng HY, Greene T, Reinker K, Swensen J, Chan RJ, Yang FC, Senbanjo L, Yang Z, Mao R, et al. Bone resorption in syndromes of the Ras/MAPK pathway. Clinical Genetics. 80: 566-73. PMID 21204800 DOI: 10.1111/j.1399-0004.2010.01619.x  0.8
2011 Li D, Hallett MA, Zhu W, Rubart M, Liu Y, Yang Z, Chen H, Haneline LS, Chan RJ, Schwartz RJ, Field LJ, Atkinson SJ, Shou W. Dishevelled-associated activator of morphogenesis 1 (Daam1) is required for heart morphogenesis. Development (Cambridge, England). 138: 303-15. PMID 21177343 DOI: 10.1242/dev.055566  0.8
2010 Zhang X, He Y, Liu S, Yu Z, Jiang ZX, Yang Z, Dong Y, Nabinger SC, Wu L, Gunawan AM, Wang L, Chan RJ, Zhang ZY. Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). Journal of Medicinal Chemistry. 53: 2482-93. PMID 20170098 DOI: 10.1021/jm901645u  0.8
2010 Zhou B, He Y, Zhang X, Xu J, Luo Y, Wang Y, Franzblau SG, Yang Z, Chan RJ, Liu Y, Zheng J, Zhang ZY. Targeting mycobacterium protein tyrosine phosphatase B for antituberculosis agents. Proceedings of the National Academy of Sciences of the United States of America. 107: 4573-8. PMID 20167798 DOI: 10.1073/pnas.0909133107  0.8
2009 Yang Z, Kondo T, Voorhorst CS, Nabinger SC, Ndong L, Yin F, Chan EM, Yu M, Würstlin O, Kratz CP, Niemeyer CM, Flotho C, Hashino E, Chan RJ. Increased c-Jun expression and reduced GATA2 expression promote aberrant monocytic differentiation induced by activating PTPN11 mutants. Molecular and Cellular Biology. 29: 4376-93. PMID 19528235 DOI: 10.1128/MCB.01330-08  0.8
2009 Zhang W, Chan RJ, Chen H, Yang Z, He Y, Zhang X, Luo Y, Yin F, Moh A, Miller LC, Payne RM, Zhang ZY, Fu XY, Shou W. Negative regulation of Stat3 by activating PTPN11 mutants contributes to the pathogenesis of Noonan syndrome and juvenile myelomonocytic leukemia. The Journal of Biological Chemistry. 284: 22353-63. PMID 19509418 DOI: 10.1074/jbc.M109.020495  0.8
2009 Chan RJ, Cooper T, Kratz CP, Weiss B, Loh ML. Juvenile myelomonocytic leukemia: a report from the 2nd International JMML Symposium. Leukemia Research. 33: 355-62. PMID 18954903 DOI: 10.1016/j.leukres.2008.08.022  0.8
2009 Goodman ML, Chen S, Yang FC, Chan RJ. Novel method of murine embryonic stem cell-derived osteoclast development. Stem Cells and Development. 18: 195-200. PMID 18616393 DOI: 10.1089/scd.2008.0193  0.8
2008 Yang Z, Li Y, Yin F, Chan RJ. Activating PTPN11 mutants promote hematopoietic progenitor cell-cycle progression and survival. Experimental Hematology. 36: 1285-96. PMID 18640765 DOI: 10.1016/j.exphem.2008.04.016  0.8
2008 Kondo T, Sheets PL, Zopf DA, Aloor HL, Cummins TR, Chan RJ, Hashino E. Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 5780-5. PMID 18391221 DOI: 10.1073/pnas.0708704105  0.8
2008 Munugalavadla V, Sims EC, Chan RJ, Lenz SD, Kapur R. Requirement for p85alpha regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT. Experimental Hematology. 36: 301-8. PMID 18179858 DOI: 10.1016/j.exphem.2007.11.008  0.8
2008 Yan J, Chen S, Zhang Y, Li X, Li Y, Wu X, Yuan J, Robling AG, Kapur R, Karpur R, Chan RJ, Yang FC. Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1. Human Molecular Genetics. 17: 936-48. PMID 18089636 DOI: 10.1093/hmg/ddm366  0.8
2007 Chan EM, Chan RJ, Comer EM, Goulet RJ, Crean CD, Brown ZD, Fruehwald AM, Yang Z, Boswell HS, Nakshatri H, Gabig TG. MOZ and MOZ-CBP cooperate with NF-kappaB to activate transcription from NF-kappaB-dependent promoters. Experimental Hematology. 35: 1782-92. PMID 17920756 DOI: 10.1016/j.exphem.2007.07.015  0.8
2007 Munugalavadla V, Sims EC, Borneo J, Chan RJ, Kapur R. Genetic and pharmacologic evidence implicating the p85 alpha, but not p85 beta, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis. Blood. 110: 1612-20. PMID 17483298 DOI: 10.1182/blood-2006-10-053058  0.8
2007 Chan RJ, Feng GS. PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase. Blood. 109: 862-7. PMID 17053061 DOI: 10.1182/blood-2006-07-028829  0.8
2006 Chan RJ, Li Y, Hass MN, Walter A, Voorhorst CS, Shelley WC, Yang Z, Orschell CM, Yoder MC. Shp-2 heterozygous hematopoietic stem cells have deficient repopulating ability due to diminished self-renewal. Experimental Hematology. 34: 1230-9. PMID 16939816 DOI: 10.1016/j.exphem.2006.04.017  0.8
2006 Chan RJ, Hromas R, Yoder MC. The role of Hex in hemangioblast and hematopoietic development. Methods in Molecular Biology (Clifton, N.J.). 330: 123-33. PMID 16846021 DOI: 10.1385/1-59745-036-7:123  0.8
2006 Zou GM, Chan RJ, Shelley WC, Yoder MC. Reduction of Shp-2 expression by small interfering RNA reduces murine embryonic stem cell-derived in vitro hematopoietic differentiation. Stem Cells (Dayton, Ohio). 24: 587-94. PMID 16269528 DOI: 10.1634/stemcells.2005-0272  0.8
2005 Chan RJ, Cripe LD. 12-O-Tetradecanoylphorbol-13-acetate in acute myeloid leukemia. Leukemia Research. 29: 1107-8. PMID 15913776 DOI: 10.1016/j.leukres.2005.04.015  0.8
2005 Chan EM, Comer EM, Brown FC, Richkind KE, Holmes ML, Chong BH, Shiffman R, Zhang DE, Slovak ML, Willman CL, Noguchi CT, Li Y, Heiber DJ, Kwan L, Chan RJ, et al. AML1-FOG2 fusion protein in myelodysplasia. Blood. 105: 4523-6. PMID 15705784 DOI: 10.1182/blood-2004-07-2762  0.8
2005 Chan RJ, Leedy MB, Munugalavadla V, Voorhorst CS, Li Y, Yu M, Kapur R. Human somatic PTPN11 mutations induce hematopoietic-cell hypersensitivity to granulocyte-macrophage colony-stimulating factor. Blood. 105: 3737-42. PMID 15644411 DOI: 10.1182/blood-2004-10-4002  0.8
2005 Li Y, McClintick J, Zhong L, Edenberg HJ, Yoder MC, Chan RJ. Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood. 105: 635-7. PMID 15358627 DOI: 10.1182/blood-2004-07-2681  0.8
2004 Chan RJ, Yoder MC. The multiple facets of hematopoietic stem cells. Current Neurovascular Research. 1: 197-206. PMID 16181070  0.8
2004 Zhong L, Li W, Yang Z, Qing K, Tan M, Hansen J, Li Y, Chen L, Chan RJ, Bischof D, Maina N, Weigel-Kelley KA, Zhao W, Larsen SH, Yoder MC, et al. Impaired nuclear transport and uncoating limit recombinant adeno-associated virus 2 vector-mediated transduction of primary murine hematopoietic cells. Human Gene Therapy. 15: 1207-18. PMID 15684697 DOI: 10.1089/hum.2004.15.1207  0.8
2004 Zhong L, Chen L, Li Y, Qing K, Weigel-Kelley KA, Chan RJ, Yoder MC, Srivastava A. Self-complementary adeno-associated virus 2 (AAV)-T cell protein tyrosine phosphatase vectors as helper viruses to improve transduction efficiency of conventional single-stranded AAV vectors in vitro and in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 950-7. PMID 15509512 DOI: 10.1016/j.ymthe.2004.07.018  0.8
2004 Chan RJ, You M, Feng GS. Identification of trans-acting factors by electrophoretic mobility shift assay. Methods in Molecular Biology (Clifton, N.J.). 249: 7-20. PMID 14573887  0.8
2003 Chan RJ, Johnson SA, Li Y, Yoder MC, Feng GS. A definitive role of Shp-2 tyrosine phosphatase in mediating embryonic stem cell differentiation and hematopoiesis. Blood. 102: 2074-80. PMID 12791646 DOI: 10.1182/blood-2003-04-1171  0.8
2003 Xie X, Chan RJ, Johnson SA, Starr M, McCarthy J, Kapur R, Yoder MC. Thrombopoietin promotes mixed lineage and megakaryocytic colony-forming cell growth but inhibits primitive and definitive erythropoiesis in cells isolated from early murine yolk sacs. Blood. 101: 1329-35. PMID 12393382 DOI: 10.1182/blood-2002-05-1468  0.8
2002 Xie X, Chan RJ, Yoder MC. Thrombopoietin acts synergistically with LIF to maintain an undifferentiated state of embryonic stem cells homozygous for a Shp-2 deletion mutation. Febs Letters. 529: 361-4. PMID 12372629 DOI: 10.1016/S0014-5793(02)03400-2  0.8
2002 Chan RJ. On physician-assisted suicide. The Pharos of Alpha Omega Alpha-Honor Medical Society. Alpha Omega Alpha. 65: 49-50. PMID 12099117  0.8
2001 Palis J, Chan RJ, Koniski A, Patel R, Starr M, Yoder MC. Spatial and temporal emergence of high proliferative potential hematopoietic precursors during murine embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. 98: 4528-33. PMID 11296291 DOI: 10.1073/pnas.071002398  0.8
2000 Hawes JW, Crabb DW, Chan RJ, Rougraff PM, Paxton R, Harris RA. Mammalian 3-hydroxyisobutyrate dehydrogenase. Methods in Enzymology. 324: 218-28. PMID 10989433  0.8
1999 Ganjoo KN, Chan RJ, Sharma M, Einhorn LH. Positron emission tomography scans in the evaluation of postchemotherapy residual masses in patients with seminoma. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 17: 3457-60. PMID 10550142  0.8
1996 Crabb DW, Stewart MJ, Chan RJ. Dexamethasone represses phorbol ester-, forskolin-, and calcium-stimulated expression of a preproenkephalin A promoter-chloramphenicol acetyltransferase gene via a receptor-mediated mechanism. Brain Research. Molecular Brain Research. 42: 103-8. PMID 8915585 DOI: 10.1016/S0169-328X(96)00119-2  0.8
1994 Chan RJ, McBride AW, Thomasson HR, Ykenney A, Crabb DW. Allele frequencies of the preproenkephalin A (PENK) gene CA repeat in Asians, African-Americans, and Caucasians: lack of evidence for different allele frequencies in alcoholics. Alcoholism, Clinical and Experimental Research. 18: 533-5. PMID 7943650 DOI: 10.1111/j.1530-0277.1994.tb00905.x  0.8
1994 Chan RJ, McBride AW, Crabb DW. Seven transmembrane domain receptor subtypes identified in NG108-15 cells by reverse transcription-polymerase chain reaction. Biochemical and Biophysical Research Communications. 205: 1311-7. PMID 7528501 DOI: 10.1006/bbrc.1994.2808  0.8
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