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Hai M. Nguyen, Ph.D. - Publications

Affiliations: 
University of California, Irvine, Irvine, CA 
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2025 Ong ST, Nam YW, Nasburg JA, Ramanishka A, Ng XR, Zhuang Z, Goay SSM, Nguyen HM, Singh L, Singh V, Rivera A, Eyster ME, Xu Y, Alper SL, Wulff H, et al. Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel K3.1. Proceedings of the National Academy of Sciences of the United States of America. 122: e2425494122. PMID 40294255 DOI: 10.1073/pnas.2425494122  0.369
2022 Nguyen PT, Nguyen HM, Wagner KM, Stewart R, Singh V, Thapa P, Chen YJ, Lillya MW, Ton AT, Kondo R, Ghetti A, Pennington MW, Hammock B, Griffith TN, Sack JT, et al. Computational design of peptides to target Na1.7 channel with high potency and selectivity for the treatment of pain. Elife. 11. PMID 36576241 DOI: 10.7554/eLife.81727  0.341
2022 Srinivasan SR, Huang H, Chang WC, Nasburg JA, Nguyen HM, Strassmaier T, Wulff H, Shakkottai VG. Discovery of novel activators of large-conductance calcium-activated potassium channels for the treatment of cerebellar ataxia. Molecular Pharmacology. PMID 35489717 DOI: 10.1124/molpharm.121.000478  0.669
2022 Orfali R, Nam YW, Nguyen HM, Rahman MA, Yang G, Cui M, Wulff H, Zhang M. Channelopathy-causing mutations in the SA/SB and HA/HB helices of K2.3 and K3.1 channels alter their apparent Ca sensitivity. Cell Calcium. 102: 102538. PMID 35030515 DOI: 10.1016/j.ceca.2022.102538  0.321
2021 Ramesha S, Rayaprolu S, Bowen CA, Giver CR, Bitarafan S, Nguyen HM, Gao T, Chen MJ, Nwabueze N, Dammer EB, Engstrom AK, Xiao H, Pennati A, Seyfried NT, Katz DJ, et al. Unique molecular characteristics and microglial origin of Kv1.3 channel-positive brain myeloid cells in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33649184 DOI: 10.1073/pnas.2013545118  0.318
2021 Fomina AF, Nguyen HM, Wulff H. Kv1.3 inhibition attenuates neuroinflammation through disruption of microglial calcium signaling. Channels (Austin, Tex.). 15: 67-78. PMID 33356832 DOI: 10.1080/19336950.2020.1853943  0.351
2020 Ong ST, Bajaj S, Tanner MR, Chang SC, Krishnarjuna B, Ng XR, Morales RAV, Chen MW, Luo D, Patel D, Yasmin S, Ng JJH, Zhuang Z, Nguyen HM, El Sahili A, et al. Modulation of Lymphocyte Potassium Channel K1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin. Acs Pharmacology & Translational Science. 3: 720-736. PMID 32832873 DOI: 10.1021/acsptsci.0c00035  0.318
2020 Sarkar S, Nguyen HM, Malovic E, Luo J, Langley M, Palanisamy BN, Singh N, Manne S, Neal M, Gabrielle M, Abdalla A, Anantharam P, Rokad D, Panicker N, Singh V, et al. Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson's disease. The Journal of Clinical Investigation. PMID 32597830 DOI: 10.1172/Jci136174  0.377
2020 Nguyen HM, di Lucente J, Chen YJ, Cui Y, Ibrahim RH, Pennington MW, Jin LW, Maezawa I, Wulff H. Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4-mediated calcium entry in microglia. Glia. PMID 32525239 DOI: 10.1002/Glia.23847  0.478
2019 Jin LW, Lucente JD, Nguyen HM, Singh V, Singh L, Chavez M, Bushong T, Wulff H, Maezawa I. Repurposing the KCa3.1 inhibitor senicapoc for Alzheimer's disease. Annals of Clinical and Translational Neurology. 6: 723-738. PMID 31019997 DOI: 10.1002/Acn3.754  0.349
2019 Brown BM, Nguyen HM, Wulff H. Recent advances in our understanding of the structure and function of more unusual cation channels. F1000research. 8. PMID 30755796 DOI: 10.12688/F1000Research.17163.1  0.48
2019 Theng Ong S, Thomas G, Kannan S, Her Z, Rui Ng X, Chew X, Nguyen HM, Wulff H, Verma C, Chen Q, Ahmed M, Chandy KG. Novel Inhibitors of the Calcium-Activated K+ Channel KCa3.1 to Treat Non-Alcoholic Fatty Liver Disease and Liver Fibrosis Biophysical Journal. 116: 249a. DOI: 10.1016/J.Bpj.2018.11.1362  0.341
2018 Di Lucente J, Nguyen HM, Wulff H, Jin LW, Maezawa I. The voltage-gated potassium channel Kv1.3 is required for microglial pro-inflammatory activation in vivo. Glia. PMID 30043400 DOI: 10.1002/Glia.23457  0.438
2018 Bednenko J, Harriman R, Mariën L, Nguyen HM, Agrawal A, Papoyan A, Bisharyan Y, Cardarelli J, Cassidy-Hanley D, Clark T, Pedersen D, Abdiche Y, Harriman W, van der Woning B, de Haard H, et al. A multiplatform strategy for the discovery of conventional monoclonal antibodies that inhibit the voltage-gated potassium channel Kv1.3. Mabs. 0. PMID 29494279 DOI: 10.1080/19420862.2018.1445451  0.452
2018 Chen YJ, Nguyen HM, Maezawa I, Jin LW, Wulff H. Inhibition of the potassium channel Kv1.3 reduces infarction and inflammation in ischemic stroke. Annals of Clinical and Translational Neurology. 5: 147-161. PMID 29468176 DOI: 10.1016/J.Bpj.2017.11.1133  0.396
2017 Maezawa I, Nguyen HM, Di Lucente J, Jenkins DP, Singh V, Hilt S, Kim K, Rangaraju S, Levey AI, Wulff H, Jin LW. Kv1.3 inhibition as a potential microglia-targeted therapy for Alzheimer's disease: preclinical proof of concept. Brain : a Journal of Neurology. PMID 29272333 DOI: 10.1093/Brain/Awx346  0.334
2017 Nguyen HM, Blomster LV, Christophersen P, Wulff H. Potassium channel expression and function in microglia: Plasticity and possible species variations. Channels (Austin, Tex.). 0. PMID 28277939 DOI: 10.1080/19336950.2017.1300738  0.459
2017 Nguyen HM, Singh V, Pressly B, Jenkins DP, Wulff H, Yarov-Yarovoy V. Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore. Molecular Pharmacology. PMID 28126850 DOI: 10.1124/Mol.116.108068  0.431
2017 Shim H, Brown B, Nguyen HM, Yarov-Yarovoy V, Wulff H. Rational Design of K Ca 2 Channel Activators Biophysical Journal. 112: 412a-413a. DOI: 10.1016/J.Bpj.2016.11.2567  0.414
2017 Nguyen HM, Grössinger EM, Horiuchi M, Davis KW, Jin L, Maezawa I, Wulff H. Differential K + Channels Expression in “Classically” and “Alternatively” Activated Microglia Biophysical Journal. 112: 333a-334a. DOI: 10.1016/J.Bpj.2016.11.1805  0.441
2016 Nguyen HM, Grössinger EM, Horiuchi M, Davis KW, Jin LW, Maezawa I, Wulff H. Differential Kv1.3, KCa3.1, and Kir2.1 expression in "classically" and "alternatively" activated microglia. Glia. PMID 27696527 DOI: 10.1002/Glia.23078  0.41
2016 Chen Y, Nguyen HM, Maezawa I, Jin L, Wulff H. The Voltage-Gated Potassium Channel Kv1.3 as a Target for Inhibiting Detrimental M1 Microglia Functions Biophysical Journal. 110: 527a-528a. DOI: 10.1016/J.Bpj.2015.11.2821  0.352
2016 Nguyen HM, Singh L, Wulff H, Yarov-Yarovoy V. Validation of KCa3.1 Channel Small Molecules Interaction Sites Predicted by Rosetta Biophysical Journal. 110: 447a. DOI: 10.1016/J.Bpj.2015.11.2405  0.458
2015 Chen YJ, Nguyen HM, Maezawa I, Grössinger EM, Garing AL, Köhler R, Jin LW, Wulff H. The potassium channel KCa3.1 constitutes a pharmacological target for neuroinflammation associated with ischemia/reperfusion stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26661208 DOI: 10.1177/0271678X15611434  0.37
2015 Coleman N, Nguyen HM, Cao Z, Brown BM, Jenkins DP, Zolkowska D, Chen YJ, Tanaka BS, Goldin AL, Rogawski MA, Pessah IN, Wulff H. The riluzole derivative 2-amino-6-trifluoromethylthio-benzothiazole (SKA-19), a mixed KCa2 activator and NaV blocker, is a potent novel anticonvulsant. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 12: 234-49. PMID 25256961 DOI: 10.1007/S13311-014-0305-Y  0.69
2015 Nguyen HM, Wulff H, Yarov-Yarovoy V. Validation of KCa3.1 Channel Nifedipine Interaction Site Predicted by Rosetta Modeling Method Biophysical Journal. 108: 582a-583a. DOI: 10.1016/J.Bpj.2014.11.3181  0.513
2014 Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, et al. Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 3952-64. PMID 24891519 DOI: 10.1096/Fj.14-251967  0.38
2014 Cao Z, Cui Y, Nguyen HM, Jenkins DP, Wulff H, Pessah IN. Nanomolar bifenthrin alters synchronous Ca2+ oscillations and cortical neuron development independent of sodium channel activity. Molecular Pharmacology. 85: 630-9. PMID 24482397 DOI: 10.1124/Mol.113.090076  0.4
2014 Nguyen HM, Chhabra S, Chang SC, Huq RU, Tanner MR, Londono LM, Gindin M, Hotez PJ, Mohanty B, Iadonato SP, Gutman GA, Beeton C, Pennington MW, Norton RS, Chandy KG. Kv1.3-Blocking Peptides from Parasitic Worms Exhibit Immunomodulatory Function Biophysical Journal. 106: 739a. DOI: 10.1016/J.Bpj.2013.11.4073  0.363
2013 Nguyen HM, Galea CA, Schmunk G, Smith BJ, Edwards RA, Norton RS, Chandy KG. Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease. The Journal of Biological Chemistry. 288: 6451-64. PMID 23300077 DOI: 10.1074/Jbc.M112.421495  0.402
2013 Nguyen HM. Modulation of Voltage-Gated K+ Channels by the Sodium Channel β1 Subunit Biophysical Journal. 104: 465. DOI: 10.1016/J.Bpj.2012.11.2571  0.525
2012 Nguyen HM, Miyazaki H, Hoshi N, Smith BJ, Nukina N, Goldin AL, Chandy KG. Modulation of voltage-gated K+ channels by the sodium channel β1 subunit. Proceedings of the National Academy of Sciences of the United States of America. 109: 18577-82. PMID 23090990 DOI: 10.1073/Pnas.1209142109  0.677
2012 Tarcha EJ, Chi V, Muñoz-Elías EJ, Bailey D, Londono LM, Upadhyay SK, Norton K, Banks A, Tjong I, Nguyen H, Hu X, Ruppert GW, Boley SE, Slauter R, Sams J, et al. Durable pharmacological responses from the peptide ShK-186, a specific Kv1.3 channel inhibitor that suppresses T cell mediators of autoimmune disease. The Journal of Pharmacology and Experimental Therapeutics. 342: 642-53. PMID 22637724 DOI: 10.1124/Jpet.112.191890  0.655
2012 Gocke AR, Lebson LA, Grishkan IV, Hu L, Nguyen HM, Whartenby KA, Chandy KG, Calabresi PA. Kv1.3 deletion biases T cells toward an immunoregulatory phenotype and renders mice resistant to autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 188: 5877-86. PMID 22581856 DOI: 10.4049/Jimmunol.1103095  0.341
2012 Nguyen HM, Calhoun JD, Isom LL, Goldin AL, Chandy GK. Modulation of Kv1 Voltage-Gated Potassium Channels by Sodium Channel Beta Subunits Biophysical Journal. 102: 687a. DOI: 10.1016/J.Bpj.2011.11.3733  0.675
2010 Nguyen HM, Goldin AL. Sodium channel carboxyl-terminal residue regulates fast inactivation. The Journal of Biological Chemistry. 285: 9077-89. PMID 20089854 DOI: 10.1074/Jbc.M109.054940  0.626
2003 Li RA, Ennis IL, Xue T, Nguyen HM, Tomaselli GF, Goldin AL, Marbán E. Molecular basis of isoform-specific micro-conotoxin block of cardiac, skeletal muscle, and brain Na+ channels. The Journal of Biological Chemistry. 278: 8717-24. PMID 12471026 DOI: 10.1074/Jbc.M210882200  0.591
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