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Christian Gachet - Publications

Affiliations: 
Strasbourg 1 
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269 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Feng M, Hechler B, Adam F, Gachet C, Eckly A, Kauskot A, Denis CV, Bryckaert M, Bobe R, Rosa JP. ADP receptor P2Y12 is the capstone of the cross-talk between Ca mobilization pathways dependent on Ca ATPases sarcoplasmic/endoplasmic reticulum type 3 and type 2b in platelets. Research and Practice in Thrombosis and Haemostasis. 7: 100004. PMID 36970741 DOI: 10.1016/j.rpth.2022.100004  0.628
2022 Couvidou A, Angénieux C, Ruch L, Mangin PH, Gachet C, Maître B. Marginal zone B cells are responsible for the production of alloantibodies following platelet transfusion in mice. Blood Advances. PMID 36490266 DOI: 10.1182/bloodadvances.2022008411  0.361
2022 Tacquard C, Mouriaux C, Delabranche X, Bourdon C, Eckly A, Magnenat S, Sattler L, Gachet C, Mertes PM, Hechler B, Mangin PH. Platelet dysfunction and thrombus instability in flow conditions in patients with severe COVID-19. Thrombosis Research. 221: 137-148. PMID 36376109 DOI: 10.1016/j.thromres.2022.11.004  0.686
2022 Mazharian A, Maître B, Bornert A, Hennequin D, Lourenco-Rodrigues M, Geer MJ, Smith CW, Heising S, Walter M, Montel F, Walker LSK, de la Salle H, Watson SP, Gachet C, Senis YA. Treatment of congenital thrombocytopenia and decreased collagen reactivity in G6b-B-deficient mice. Blood Advances. PMID 36269841 DOI: 10.1182/bloodadvances.2022008873  0.376
2022 Lee RH, Ghalloussi D, Harousseau GL, Kenny JP, Kramer PA, Proamer F, Nieswandt B, Flick MJ, Gachet C, Casari C, Eckly A, Bergmeier W. Rasa3 deficiency minimally impacts thrombopoiesis but promotes severe thrombocytopenia due to integrin-dependent platelet clearance. Jci Insight. PMID 35290242 DOI: 10.1172/jci.insight.155676  0.405
2022 El Mdawar MB, Maître B, Magnenat S, Tupin F, Jönsson F, Gachet C, de la Salle H, Hechler B. Platelet FcγRIIA-induced serotonin release exacerbates the severity of transfusion-related acute lung injury in mice. Blood Advances. 5: 4817-4830. PMID 34521102 DOI: 10.1182/bloodadvances.2021004336  0.682
2021 Rabouël Y, Magnenat S, Lefebvre F, Delabranche X, Gachet C, Hechler B. Transfusion of fresh washed platelets does not prevent experimental polymicrobial-induced septic shock in mice. Journal of Thrombosis and Haemostasis : Jth. 20: 449-460. PMID 34752015 DOI: 10.1111/jth.15583  0.701
2021 Spieker CJ, Závodszky G, Mouriaux C, van der Kolk M, Gachet C, Mangin PH, Hoekstra AG. The Effects of Micro-vessel Curvature Induced Elongational Flows on Platelet Adhesion. Annals of Biomedical Engineering. PMID 34668098 DOI: 10.1007/s10439-021-02870-4  0.301
2021 Janus-Bell E, Yakusheva A, Scandola C, Receveur N, Muhammad-Usman A, Mouriaux C, Bourdon C, Loubière C, Eckly A, Senis YA, Panteleev MA, Gachet C, Mangin PH. Characterization of the role of integrin α5β1 in platelet function, hemostasis and experimental thrombosis. Thrombosis and Haemostasis. PMID 34598304 DOI: 10.1055/a-1659-6214  0.419
2021 Rabouel Y, Magnenat S, Delabranche X, Gachet C, Hechler B. Platelet P2Y Receptor Deletion or Pharmacological Inhibition does not Protect Mice from Sepsis or Septic Shock. Th Open : Companion Journal to Thrombosis and Haemostasis. 5: e343-e352. PMID 34447900 DOI: 10.1055/s-0041-1733857  0.689
2021 Bornert A, Pertuy F, Lanza F, Gachet C, Léon C. In Vivo Two-photon Imaging of Megakaryocytes and Proplatelets in the Mouse Skull Bone Marrow. Journal of Visualized Experiments : Jove. PMID 34398145 DOI: 10.3791/62515  0.305
2021 Ahmed MU, Receveur N, Janus-Bell E, Mouriaux C, Gachet C, Jandrot-Perrus M, Hechler B, Gardiner EE, Mangin PH. Respective roles of Glycoprotein VI and FcγRIIA in the regulation of αIIbβ3-mediated platelet activation to fibrinogen, thrombus buildup, and stability. Research and Practice in Thrombosis and Haemostasis. 5: e12551. PMID 34263103 DOI: 10.1002/rth2.12551  0.72
2021 Strassel C, Magiera MM, Dupuis A, Batzenschlager M, Hovasse A, Pleines I, Guéguen P, Eckly A, Moog S, Mallo L, Kimmerlin Q, Chappaz S, Strub JM, Kathiresan N, Salle H, ... ... Gachet C, et al. Correction: An essential role for α4A-tubulin in platelet biogenesis. Life Science Alliance. 4. PMID 34155037 DOI: 10.26508/lsa.202101132  0.369
2021 Ravanat C, Pongérard A, Freund M, Heim V, Rudwill F, Ziessel C, Eckly A, Proamer F, Isola H, Gachet C. Human platelets labeled at two discrete biotin densities are functional in vitro and are detected in vivo in the murine circulation: A promising approach to monitor platelet survival in vivo in clinical research. Transfusion. PMID 33580977 DOI: 10.1111/trf.16312  0.346
2021 Isola H, Ravanat C, Rudwill F, Pongerard A, Haas D, Eckly A, Gachet C, Hechler B. Removal of citrate from PAS-III additive solution improves functional and biochemical characteristics of buffy-coat platelet concentrates stored for 7 days, with or without INTERCEPT pathogen reduction. Transfusion. PMID 33527430 DOI: 10.1111/trf.16280  0.653
2020 Dupuis A, Bordet JC, Eckly A, Gachet C. Platelet δ-Storage Pool Disease: An Update. Journal of Clinical Medicine. 9. PMID 32759727 DOI: 10.3390/Jcm9082508  0.463
2020 Selvadurai MV, Moon MJ, Mountford SJ, Ma X, Zheng Z, Jennings IG, Setiabakti NM, Iman RP, Brazilek RJ, Z Abidin NA, Chicanne G, Severin S, Nicholls AJ, Wong CHY, Rinckel JY, ... ... Gachet C, et al. Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation. Science Translational Medicine. 12. PMID 32718993 DOI: 10.1126/Scitranslmed.Aar8430  0.499
2020 Eckly A, Scandola C, Oprescu A, Michel D, Rinckel JY, Proamer F, Hoffmann D, Receveur N, Léon C, Bear JE, Ghalloussi D, Harousseau G, Bergmeier W, Lanza F, Gaits-Iacovoni F, ... ... Gachet C, et al. Megakaryocytes use in vivo podosome-like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids. Journal of Thrombosis and Haemostasis : Jth. PMID 32702204 DOI: 10.1111/Jth.15024  0.407
2020 Ahmed MU, Kaneva V, Loyau S, Nechipurenko D, Receveur N, Le Bris M, Janus-Bell E, Didelot M, Rauch A, Susen S, Chakfé N, Lanza F, Gardiner EE, Andrews RK, Panteleev M, ... Gachet C, et al. Pharmacological Blockade of GPVI Promotes Thrombus Disaggregation in the Absence of Thrombin. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120314301. PMID 32698684 DOI: 10.1161/Atvbaha.120.314301  0.469
2020 Gachet C, Hechler B. Platelet Purinergic Receptors in Thrombosis and Inflammation. Hamostaseologie. 40: 145-152. PMID 32464678 DOI: 10.1055/A-1113-0711  0.761
2020 Bornert A, Boscher J, Pertuy F, Eckly A, Stegner D, Strassel C, Gachet C, Lanza F, Léon C. Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation. Haematologica. PMID 32327502 DOI: 10.3324/Haematol.2019.239111  0.388
2020 Jacobson KA, Delicado EG, Gachet C, Kennedy C, von Kügelgen I, Li B, Miras-Portugal MT, Novak I, Schöneberg T, Perez-Sen R, Thor D, Wu B, Yang Z, Müller CE. Update of P2Y Receptor Pharmacology: IUPHAR Review:"27". British Journal of Pharmacology. PMID 32037507 DOI: 10.1111/Bph.15005  0.367
2020 Do Sacramento V, Mallo L, Freund M, Eckly A, Hechler B, Mangin P, Lanza F, Gachet C, Strassel C. Functional properties of human platelets derived in vitro from CD34 cells. Scientific Reports. 10: 914. PMID 31969609 DOI: 10.1038/S41598-020-57754-9  0.722
2019 Receveur N, Nechipurenko D, Knapp Y, Yakusheva A, Maurer E, Denis CV, Lanza F, Panteleev M, Gachet C, Mangin PH. Shear rate gradients promote a bi-phasic thrombus formation on weak adhesive proteins, such as fibrinogen in a VWF-dependent manner. Haematologica. PMID 31727765 DOI: 10.3324/Haematol.2019.235754  0.418
2019 Lunghi B, Lecchi A, Santacroce R, Scavone M, Paniccia R, Artoni A, Gachet C, Castaman G, Margaglione M, Bernardi F, Cattaneo M. Severe bleeding and absent ADP-induced platelet aggregation associated with inherited combined CalDAG-GEFI and P2Y12 deficiencies. Haematologica. PMID 31649128 DOI: 10.3324/Haematol.2019.232850  0.469
2019 Hechler B, Dupuis A, Mangin PH, Gachet C. Platelet preparation for function testing in the laboratory and clinic: Historical and practical aspects. Research and Practice in Thrombosis and Haemostasis. 3: 615-625. PMID 31624781 DOI: 10.1002/rth2.12240  0.68
2019 Aguilar A, Weber J, Boscher J, Freund M, Ziessel C, Eckly A, Magnenat S, Bourdon C, Hechler B, Mangin PH, Gachet C, Lanza F, Léon C. Combined deficiency of RAB32 and RAB38 in the mouse mimics Hermansky-Pudlak syndrome and critically impairs thrombosis. Blood Advances. 3: 2368-2380. PMID 31399401 DOI: 10.1182/Bloodadvances.2019031286  0.675
2019 Angénieux C, Dupuis A, Gachet C, de la Salle H, Maître B. Cell surface expression of HLA I molecules as a marker of young platelets. Journal of Thrombosis and Haemostasis : Jth. PMID 31207003 DOI: 10.1111/Jth.14537  0.453
2019 El Mdawar MB, Maître B, Magnenat S, Gachet C, Hechler B, de la Salle H. The ATP-gated P2X ion channel contributes to the severity of antibody-mediated Transfusion-Related Acute Lung Injury in mice. Scientific Reports. 9: 5159. PMID 30914724 DOI: 10.1038/S41598-019-41742-9  0.625
2019 Mertes PM, Tacquard C, Andreu G, Kientz D, Gross S, Malard L, Drouet C, Carlier M, Gachet C, Sandid I, Boudjedir K. Hypersensitivity transfusion reactions to platelet concentrate: a retrospective analysis of the French hemovigilance network. Transfusion. PMID 30907010 DOI: 10.1111/Trf.15275  0.338
2019 Strassel C, Magiera MM, Dupuis A, Batzenschlager M, Hovasse A, Pleines I, Guéguen P, Eckly A, Moog S, Mallo L, Kimmerlin Q, Chappaz S, Strub JM, Kathiresan N, de la Salle H, ... ... Gachet C, et al. An essential role for α4A-tubulin in platelet biogenesis. Life Science Alliance. 2. PMID 30760556 DOI: 10.26508/lsa.201900309  0.336
2019 Nechipurenko DY, Receveur N, Yakimenko AO, Shepelyuk TO, Yakusheva AA, Kerimov RR, Obydennyy SI, Eckly A, Léon C, Gachet C, Grishchuk EL, Ataullakhanov FI, Mangin PH, Panteleev MA. Clot Contraction Drives the Translocation of Procoagulant Platelets to Thrombus Surface. Arteriosclerosis, Thrombosis, and Vascular Biology. 39: 37-47. PMID 30580561 DOI: 10.1161/Atvbaha.118.311390  0.507
2018 Selvadurai MV, Brazilek RJ, Moon MJ, Rinckel JY, Eckly A, Gachet C, Meikle PJ, Nandurkar HH, Nesbitt WS, Hamilton JR. The PI 3-kinase PI3KC2α regulates mouse platelet membrane structure and function independently of membrane lipid composition. Febs Letters. PMID 30421419 DOI: 10.1002/1873-3468.13295  0.384
2018 Strassel C, Moog S, Mallo L, Eckly A, Freund M, Gachet C, Lanza F. Microtubule plus-end tracking Adenopolyposis Coli negatively regulates proplatelet formation. Scientific Reports. 8: 15808. PMID 30361531 DOI: 10.1038/S41598-018-34118-Y  0.442
2018 Fukumoto Y, Tanaka KF, Parajuli B, Shibata K, Yoshioka H, Kanemaru K, Gachet C, Ikenaka K, Koizumi S, Kinouchi H. Neuroprotective effects of microglial P2Y receptors against ischemic neuronal injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X18805317. PMID 30334687 DOI: 10.1177/0271678X18805317  0.347
2018 Strassel C, Gachet C, Lanza F. On the Way to Platelet Production. Frontiers in Medicine. 5: 239. PMID 30211166 DOI: 10.3389/Fmed.2018.00239  0.449
2018 Strassel C, Gachet C, Lanza F. On the way to in vitro platelet production. Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine. PMID 30150135 DOI: 10.1016/J.Tracli.2018.07.005  0.437
2018 Dupuis A, Gachet C. Inherited platelet disorders : Management of the bleeding risk. Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine. PMID 30077511 DOI: 10.1016/J.Tracli.2018.07.003  0.429
2018 Humbrecht C, Somme S, Renaudier P, Gross S, Gachet C, Schlanger S. [Comparative study on platelet transfusion in Lorraine-Champagne and Alsace in 2015]. Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine. PMID 30076013 DOI: 10.1016/J.Tracli.2018.06.001  0.458
2018 Garraud O, Gachet C. Platelets: A more than a centenary old Odyssey and more to come. Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine. 25: 149-150. PMID 30049627 DOI: 10.1016/J.Tracli.2018.06.007  0.477
2018 Humbrecht C, Kientz D, Gachet C. Platelet transfusion: Current challenges. Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine. PMID 30037501 DOI: 10.1016/J.Tracli.2018.06.004  0.462
2018 Kientz D, Humbrecht C, Isola H, Gachet C. [Adaptation of platelet concentrates delivery to HAS/ANSM requirements evolution in EFS Grand-Est]. Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine. 25: 187-191. PMID 30025993 DOI: 10.1016/J.Tracli.2018.06.006  0.415
2018 Beutier H, Hechler B, Godon O, Wang Y, Gillis CM, de Chaisemartin L, Gouel-Chéron A, Magnenat S, Macdonald LE, Murphy AJ, Chollet-Martin S, Longrois D, Gachet C, Bruhns P, et al. Platelets expressing IgG receptor FcγRIIA/CD32A determine the severity of experimental anaphylaxis. Science Immunology. 3. PMID 29654057 DOI: 10.1126/Sciimmunol.Aan5997  0.749
2018 Ouadi A, Bekaert V, Receveur N, Thomas L, Lanza F, Marchand P, Gachet C, Mangin PH, Brasse D, Laquerriere P. Imaging thrombosis withTc-labeled RAM.1-antibody in vivo. Nuclear Medicine and Biology. 61: 21-27. PMID 29625391 DOI: 10.1016/J.Nucmedbio.2018.03.003  0.3
2018 de la Salle H, Angénieux C, Lanza F, Gachet C. Retinoic acid receptor-α regulates synthetic events in human platelets: comment. Journal of Thrombosis and Haemostasis : Jth. 16: 1013-1014. PMID 29504265 DOI: 10.1111/jth.13992  0.315
2018 Mangin PH, Onselaer MB, Receveur N, Le Lay N, Hardy AT, Wilson C, Sanchez X, Loyau S, Dupuis A, Babar AK, Miller JL, Philippou H, Hughes CE, Herr AB, Ariëns RA, ... ... Gachet C, et al. Immobilized fibrinogen activates human platelets through GPVI. Haematologica. PMID 29472360 DOI: 10.3324/Haematol.2017.182972  0.517
2018 Vermehren P, Trotman-Lucas M, Hechler B, Gachet C, Evans R, Gibson C, Fern R. Cooperation between NMDA-Type Glutamate and P2 Receptors for Neuroprotection during Stroke: Combining Astrocyte and Neuronal Protection Neuroglia. 1: 30-47. DOI: 10.3390/NEUROGLIA1010005  0.581
2018 Dupuis A, Böckelmann D, Laeuffer P, Neubauer K, Gachet C, Zieger B. Two Novel Compound Heterozygous Pathogenic Variants in P2YR12 gene Blood. 132: 1154-1154. DOI: 10.1182/Blood-2018-99-112833  0.476
2017 Gaertner F, Ahmad Z, Rosenberger G, Fan S, Nicolai L, Busch B, Yavuz G, Luckner M, Ishikawa-Ankerhold H, Hennel R, Benechet A, Lorenz M, Chandraratne S, Schubert I, Helmer S, ... ... Gachet C, et al. Migrating Platelets Are Mechano-scavengers that Collect and Bundle Bacteria. Cell. 171: 1368-1382.e23. PMID 29195076 DOI: 10.1016/J.Cell.2017.11.001  0.477
2017 Hechler B, Ravanat C, Gachet C. Amotosalen/UVA pathogen inactivation technology reduces platelet activability, induces apoptosis and accelerates clearance. Haematologica. 102: e502-e503. PMID 29192131 DOI: 10.3324/Haematol.2017.180539  0.702
2017 Lavergne M, Janus-Bell E, Schaff M, Gachet C, Mangin PH. Platelet Integrins in Tumor Metastasis: Do They Represent a Therapeutic Target? Cancers. 9. PMID 28956830 DOI: 10.3390/Cancers9100133  0.474
2017 Ayme-Dietrich E, Lawson R, Côté F, de Tapia C, Da Silva S, Ebel C, Hechler B, Gachet C, Guyonnet J, Rouillard H, Stoltz J, Quentin E, Banas S, Daubeuf F, Frossard N, et al. Serotonergic 5-HT2B receptors in mitral valvulopathy: bone marrow mobilization of endothelial progenitors. British Journal of Pharmacology. PMID 28806488 DOI: 10.1111/Bph.13981  0.594
2017 Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K, Tanaka KF, Koizumi S. Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y1 Receptor Downregulation. Cell Reports. 19: 1151-1164. PMID 28494865 DOI: 10.1016/J.Celrep.2017.04.047  0.361
2017 Alberio L, Ravanat C, Hechler B, Mangin PH, Lanza F, Gachet C. Delayed-onset of procoagulant signalling revealed by kinetic analysis of COAT platelet formation. Thrombosis and Haemostasis. PMID 28382366 DOI: 10.1160/Th16-09-0711  0.692
2017 Saultier P, Vidal L, Canault M, Bernot D, Falaise C, Pouymayou C, Bordet JC, Saut N, Rostan A, Baccini V, Peiretti F, Favier M, Lucca P, Deleuze JF, Olaso R, ... ... Gachet C, et al. Macrothrombocytopenia and dense granule deficiency associated with FLI1 variants: ultrastructural and pathogenic features. Haematologica. PMID 28255014 DOI: 10.3324/Haematol.2016.153577  0.4
2017 Benbarche S, Strassel C, Angénieux C, Mallo L, Freund M, Gachet C, Lanza F, de la Salle H. Dual role of IL-21 in megakaryopoiesis and platelet homeostasis. Haematologica. PMID 28057742 DOI: 10.3324/Haematol.2016.143958  0.324
2016 Ollivier V, Roques C, Receveur N, Gratz M, Feldman L, Letourneur D, Gachet C, Mangin PH, Jandrot-Perrus M. Bioreactivity of stent material: Activation of platelets, coagulation, leukocytes and endothelial cell dysfunction in vitro. Platelets. 1-11. PMID 28032527 DOI: 10.1080/09537104.2016.1252836  0.47
2016 Mammadova-Bach E, Zigrino P, Brucker C, Bourdon C, Freund M, De Arcangelis A, Abrams SI, Orend G, Gachet C, Mangin PH. Platelet integrin α6β1 controls lung metastasis through direct binding to cancer cell-derived ADAM9. Jci Insight. 1: e88245. PMID 27699237 DOI: 10.1172/Jci.Insight.88245  0.468
2016 Lavenu-Bombled C, Guitton C, Dupuis A, Baas MJ, Desconclois C, Dreyfus M, Li R, Caron C, Gachet C, Fressinaud E, Lanza F. A novel platelet-type von Willebrand disease mutation (GP1BA p.Met255Ile) associated with type 2B "Malmö/New York" von Willebrand disease. Thrombosis and Haemostasis. 116. PMID 27683759 DOI: 10.1160/Th16-06-0438  0.363
2016 Eckly A, Rinckel JY, Proamer F, Ulas N, Joshi S, Whiteheart SW, Gachet C. Respective contributions of single and compound granule fusion to secretion by activated platelets. Blood. 128: 2538-2549. PMID 27625359 DOI: 10.1182/Blood-2016-03-705681  0.404
2016 Lecchi A, Femia EA, Paoletta S, Dupuis A, Ohlmann P, Gachet C, Jacobson KA, Machura K, Podda GM, Zieger B, Cattaneo M. Inherited dysfunctional platelet P2Y12 receptor mutations associated with bleeding disorders. Hamostaseologie. 36. PMID 27487748 DOI: 10.5482/Hamo-16-03-0010  0.511
2016 Podoplelova NA, Sveshnikova AN, Kotova YN, Eckly A, Receveur N, Nechipurenko DY, Obydennyi SI, Kireev II, Gachet C, Ataullakhanov FI, Mangin PH, Panteleev MA. Coagulation factors bound to procoagulant platelets concentrate in cap structures to promote clotting. Blood. 128: 1745-55. PMID 27432876 DOI: 10.1182/Blood-2016-02-696898  0.456
2016 Ohlmann P, Hechler B, Chafey P, Ravanat C, Isola H, Wiesel ML, Cazenave JP, Gachet C. Hemostatic properties and protein expression profile of therapeutic apheresis plasma treated with amotosalen and ultraviolet A for pathogen inactivation. Transfusion. 56: 2239-47. PMID 27250038 DOI: 10.1111/Trf.13670  0.615
2016 Strassel C, Bull A, Moog S, Receveur N, Mallo L, Mangin P, Eckly A, Freund M, Dubart-Kupperschmitt A, Gachet C, Lanza F. Lentiviral gene rescue of a Bernard-Soulier mouse model to study platelet glycoprotein Ibβ function. Journal of Thrombosis and Haemostasis : Jth. PMID 27148783 DOI: 10.1111/Jth.13355  0.45
2016 Hechler B, Maître B, Magnenat S, Heim V, El Mdawar MB, Gachet C, de la Salle H. Platelets are dispensable for antibody-mediated transfusion-related acute lung injury in the mouse. Journal of Thrombosis and Haemostasis : Jth. 14: 1255-67. PMID 27063192 DOI: 10.1111/Jth.13335  0.692
2016 Strassel C, Brouard N, Mallo L, Receveur N, Mangin P, Eckly A, Bieche I, Tarte K, Gachet C, Lanza F. Aryl hydrocarbon receptor-dependent enrichment of a megakaryocytic precursor with a high potential to produce proplatelets. Blood. 127: 2231-40. PMID 26966088 DOI: 10.1182/Blood-2015-09-670208  0.411
2016 Angénieux C, Maître B, Eckly A, Lanza F, Gachet C, de la Salle H. Time-Dependent Decay of mRNA and Ribosomal RNA during Platelet Aging and Its Correlation with Translation Activity. Plos One. 11: e0148064. PMID 26808079 DOI: 10.1371/Journal.Pone.0148064  0.464
2016 Gachet C. Antiplatelet drugs: which targets for which treatments? Journal of Thrombosis and Haemostasis : Jth. S313-22. PMID 26149041 DOI: 10.1111/Jth.12947  0.359
2016 Hechler B, Zimmermann C, Rabouel Y, Magnenat S, Burban M, Boisramé-Helms J, Meziani F, Gachet C. A Potential Protective Role of Platelets during Septic Shock Does Not Depend on Their Purinergic Receptors Blood. 128: 2537-2537. DOI: 10.1182/Blood.V128.22.2537.2537  0.7
2016 Strassel C, Hovasse A, Moog S, Mageira M, Batzenschlager M, Schaeffer-Reiss C, Kile B, Gachet C, Janke C, Lanza F. Selected Expression and Functional Importance of α4a-Tubulin in Platelet Biogenesis Blood. 128: 1360-1360. DOI: 10.1182/Blood.V128.22.1360.1360  0.473
2015 Schaff M, Gachet C, Mangin PH. [Anti-platelets without a bleeding risk: novel targets and strategies]. Biologie Aujourd'Hui. 209: 211-28. PMID 26820829 DOI: 10.1051/Jbio/2015023  0.456
2015 Dupuis A, Heim V, Ohlmann P, Gachet C. In Vitro Binding of [³H]PSB-0413 to P2Y₁₂ Receptors Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. 71: 1.35.1-1.35.19. PMID 26646192 DOI: 10.1002/0471141755.Ph0135S71  0.433
2015 Hechler B, Gachet C. Purinergic Receptors in Thrombosis and Inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology. 35: 2307-15. PMID 26359511 DOI: 10.1161/Atvbaha.115.303395  0.712
2015 Mammadova-Bach E, Mangin P, Lanza F, Gachet C. Platelets in cancer. From basic research to therapeutic implications. HäMostaseologie. 35: 325-36. PMID 26289826 DOI: 10.5482/Hamo-14-11-0065  0.434
2015 Maurer E, Schaff M, Receveur N, Bourdon C, Mercier L, Nieswandt B, Dubois C, Jandrot-Perrus M, Goetz J, Lanza F, Gachet C, Mangin PH. Fibrillar cellular fibronectin supports efficient platelet function and procoagulant activity. Thrombosis and Haemostasis. 114. PMID 26245230 DOI: 10.1160/Th14-11-0958  0.544
2015 Mammadova-Bach E, Ollivier V, Loyau S, Schaff M, Dumont B, Favier R, Freyburger G, Latger-Cannard V, Nieswandt B, Gachet C, Mangin PH, Jandrot-Perrus M. Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation. Blood. PMID 25977585 DOI: 10.1182/Blood-2015-02-629717  0.535
2015 Ciciliano JC, Sakurai Y, Myers DR, Fay ME, Hechler B, Meeks S, Li R, Dixon JB, Lyon LA, Gachet C, Lam WA. Resolving the multifaceted mechanisms of the ferric chloride thrombosis model using an interdisciplinary microfluidic approach. Blood. PMID 25931587 DOI: 10.1182/Blood-2015-02-628594  0.667
2015 Mumford AD, Frelinger AL, Gachet C, Gresele P, Noris P, Harrison P, Mezzano D. A review of platelet secretion assays for the diagnosis of inherited platelet secretion disorders. Thrombosis and Haemostasis. 114: 14-25. PMID 25879272 DOI: 10.1160/Th14-11-0999  0.427
2015 Donnet T, Ravanat C, Eckly A, Maurer E, Alame G, Ziessel C, Mangin PH, Freund M, Cazenave JP, Gachet C, Rendu F. Dehydration of blood platelets by zeodration: in vitro characterization and hemostatic properties in vivo. Transfusion. 55: 2207-18. PMID 25856501 DOI: 10.1111/Trf.13121  0.419
2015 Mountford JK, Petitjean C, Putra HW, McCafferty JA, Setiabakti NM, Lee H, Tønnesen LL, McFadyen JD, Schoenwaelder SM, Eckly A, Gachet C, Ellis S, Voss AK, Dickins RA, Hamilton JR, et al. The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function. Nature Communications. 6: 6535. PMID 25779105 DOI: 10.1038/Ncomms7535  0.451
2015 Badirou I, Pan J, Souquere S, Legrand C, Pierron G, Wang A, Eckly A, Roy A, Gachet C, Vainchenker W, Chang Y, Léon C. Distinct localizations and roles of non-muscle myosin II during proplatelet formation and platelet release. Journal of Thrombosis and Haemostasis : Jth. 13: 851-9. PMID 25736522 DOI: 10.1111/Jth.12887  0.348
2015 Gampe K, Haverkamp S, Robson SC, Gachet C, Hüser L, Acker-Palmer A, Zimmermann H. NTPDase2 and the P2Y1 receptor are not required for mammalian eye formation. Purinergic Signalling. 11: 155-60. PMID 25504514 DOI: 10.1007/S11302-014-9440-5  0.307
2015 Maître B, Magnenat S, Heim V, Ravanat C, Evans RJ, de la Salle H, Gachet C, Hechler B. The P2X1 receptor is required for neutrophil extravasation during lipopolysaccharide-induced lethal endotoxemia in mice. Journal of Immunology (Baltimore, Md. : 1950). 194: 739-49. PMID 25480563 DOI: 10.4049/Jimmunol.1401786  0.667
2015 Lecchi A, Razzari C, Paoletta S, Dupuis A, Nakamura L, Ohlmann P, Gachet C, Jacobson KA, Zieger B, Cattaneo M. Identification of a new dysfunctional platelet P2Y12 receptor variant associated with bleeding diathesis. Blood. 125: 1006-13. PMID 25428217 DOI: 10.1182/Blood-2013-07-517896  0.492
2015 Pertuy F, Aguilar A, Strassel C, Eckly A, Freund JN, Duluc I, Gachet C, Lanza F, Léon C. Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage. Journal of Thrombosis and Haemostasis : Jth. 13: 115-25. PMID 25393502 DOI: 10.1111/Jth.12784  0.418
2015 Alame G, Mangin PH, Freund M, Riehl N, Magnenat S, Petitou M, Hechler B, Gachet C. EP217609, a neutralisable dual-action FIIa/FXa anticoagulant, with antithrombotic effects in arterial thrombosis. Thrombosis and Haemostasis. 113: 385-95. PMID 25374268 DOI: 10.1160/Th14-05-0399  0.627
2015 Strassel C, Kubovcakova L, Mangin PH, Ravanat C, Freund M, Skoda RC, Denis CV, Dupuis A, Herbrecht R, Gachet C, Lanza F. Haemorrhagic and thrombotic diatheses in mouse models with thrombocytosis. Thrombosis and Haemostasis. 113: 414-25. PMID 25298269 DOI: 10.1160/Th14-08-0667  0.43
2015 Hechler B, Ravanat C, Ohlmann P, Eckly A, Leduc M, Guillonneau F, Isola H, Gachet C. L’inactivation des pathogènes par la technologie Intercept® préserve l’ultrastructure et les propriétés biochimiques des plaquettes au cours de leur conservation en vue de transfusion Transfusion Clinique Et Biologique. 22: 222. DOI: 10.1016/J.Tracli.2015.06.026  0.576
2014 Gresele P, Harrison P, Bury L, Falcinelli E, Gachet C, Hayward CP, Kenny D, Mezzano D, Mumford AD, Nugent D, Nurden AT, Orsini S, Cattaneo M. Diagnosis of suspected inherited platelet function disorders: Results of a worldwide survey Journal of Thrombosis and Haemostasis. 12: 1562-1569. PMID 24976115 DOI: 10.1111/Jth.12650  0.375
2014 Shinozaki Y, Nomura M, Iwatsuki K, Moriyama Y, Gachet C, Koizumi S. Microglia trigger astrocyte-mediated neuroprotection via purinergic gliotransmission. Scientific Reports. 4: 4329. PMID 24710318 DOI: 10.1038/Srep04329  0.328
2014 Prudent M, D'Alessandro A, Cazenave JP, Devine DV, Gachet C, Greinacher A, Lion N, Schubert P, Steil L, Thiele T, Tissot JD, Völker U, Zolla L. Proteome changes in platelets after pathogen inactivation--an interlaboratory consensus. Transfusion Medicine Reviews. 28: 72-83. PMID 24685438 DOI: 10.1016/J.Tmrv.2014.02.002  0.463
2014 Tersteeg C, Heijnen HF, Eckly A, Pasterkamp G, Urbanus RT, Maas C, Hoefer IE, Nieuwland R, Farndale RW, Gachet C, de Groot PG, Roest M. FLow-induced PRotrusions (FLIPRs): a platelet-derived platform for the retrieval of microparticles by monocytes and neutrophils. Circulation Research. 114: 780-91. PMID 24406984 DOI: 10.1161/Circresaha.114.302361  0.471
2014 Pertuy F, Eckly A, Weber J, Proamer F, Rinckel JY, Lanza F, Gachet C, Léon C. Myosin IIA is critical for organelle distribution and F-actin organization in megakaryocytes and platelets. Blood. 123: 1261-9. PMID 24243973 DOI: 10.1182/Blood-2013-06-508168  0.402
2014 Jandrot-Perrus M, Mammadova-Bach E, Ollivier V, Loyau S, Gachet C, Mangin PH. GPVI Interaction with Polymerized Fibrin Boosts Thrombin Generation and Thrombus Growth Blood. 124: 4152-4152. DOI: 10.1182/Blood.V124.21.4152.4152  0.519
2013 Gachet C. [Molecular mechanisms of platelet activation]. Bulletin De L'Academie Nationale De Medecine. 197: 361-73. PMID 24919366  0.376
2013 Pleines I, Dütting S, Cherpokova D, Eckly A, Meyer I, Morowski M, Krohne G, Schulze H, Gachet C, Debili N, Brakebusch C, Nieswandt B. Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42. Blood. 122: 3178-87. PMID 23861250 DOI: 10.1182/Blood-2013-03-487942  0.458
2013 Schaff M, Tang C, Maurer E, Bourdon C, Receveur N, Eckly A, Hechler B, Arnold C, De Arcangelis A, Nieswandt B, Denis CV, Lefebvre O, Georges-Labouesse E, Gachet C, Lanza F, et al. Integrin α6β1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis Circulation. 128: 541-552. PMID 23797810 DOI: 10.1161/Circulationaha.112.000799  0.699
2013 Maurer E, Tang C, Schaff M, Bourdon C, Receveur N, Ravanat C, Eckly A, Hechler B, Gachet C, Lanza F, Mangin PH. Targeting platelet GPIbβ reduces platelet adhesion, GPIb signaling and thrombin generation and prevents arterial thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1221-9. PMID 23559635 DOI: 10.1161/Atvbaha.112.301013  0.724
2013 Noguchi Y, Shinozaki Y, Fujishita K, Shibata K, Imura Y, Morizawa Y, Gachet C, Koizumi S. Astrocytes protect neurons against methylmercury via ATP/P2Y(1) receptor-mediated pathways in astrocytes. Plos One. 8: e57898. PMID 23469098 DOI: 10.1371/Journal.Pone.0057898  0.331
2013 Hechler B, Ohlmann P, Chafey P, Ravanat C, Eckly A, Maurer E, Mangin P, Isola H, Cazenave JP, Gachet C. Preserved functional and biochemical characteristics of platelet components prepared with amotosalen and ultraviolet A for pathogen inactivation. Transfusion. 53: 1187-200. PMID 23067365 DOI: 10.1111/J.1537-2995.2012.03923.X  0.673
2013 Zahid M, Mangin P, Loyau S, Hechler B, Billiald P, Gachet C, Jandrot-Perrus M. The future of glycoprotein VI as an antithrombotic target. Journal of Thrombosis and Haemostasis : Jth. 10: 2418-27. PMID 23020554 DOI: 10.1111/Jth.12009  0.636
2013 Ohlmann P, Lecchi A, El-Tayeb A, Müller CE, Cattaneo M, Gachet C. The platelet P2Y12 receptor under normal and pathological conditions. Assessment with the radiolabeled selective antagonist [3H]PSB-0413 Purinergic Signalling. 9: 59-66. PMID 22892887 DOI: 10.1007/S11302-012-9329-0  0.463
2013 Maitre B, Leguay C, De La Salle H, Hechler B, Gachet C. NF449, un antagoniste du récepteur P2X1, inhibe le développement du TRALI dans un modèle murin Transfusion Clinique Et Biologique. 20: 289. DOI: 10.1016/J.Tracli.2013.04.016  0.583
2013 Hechler B, Ohlmann P, Chafey P, Ravanat C, Eckly A, Maurer E, Mangin P, Isola H, Cazenave J, Gachet C. L’inactivation des pathogènes par la technologie Intercept® préserve les propriétés fonctionnelles et biochimiques des plaquettes au cours de leur conservation en vue de transfusion Transfusion Clinique Et Biologique. 20: 334. DOI: 10.1016/J.Tracli.2013.03.152  0.573
2013 Gachet C, Hechler B. The P2Y receptors and thrombosis Wiley Interdisciplinary Reviews: Membrane Transport and Signaling. 2: 241-253. DOI: 10.1002/WMTS.97  0.65
2012 Morel O, El Ghannudi S, Hess S, Reydel A, Crimizade U, Jesel L, Radulescu B, Wiesel ML, Gachet C, Ohlmann P. The extent of P2Y12 inhibition by clopidogrel in diabetes mellitus patients with acute coronary syndrome is not related to glycaemic control: roles of white blood cell count and body weight. Thrombosis and Haemostasis. 108: 338-48. PMID 22740070 DOI: 10.1160/Th11-12-0876  0.39
2012 Gachet C. P2Y(12) receptors in platelets and other hematopoietic and non-hematopoietic cells. Purinergic Signalling. 8: 609-19. PMID 22528678 DOI: 10.1007/S11302-012-9303-X  0.543
2012 Horckmans M, Robaye B, Léon-Gόmez E, Lantz N, Unger P, Dol-Gleizes F, Clouet S, Cammarata D, Schaeffer P, Savi P, Gachet C, Balligand JL, Dessy C, Boeynaems JM, Communi D. P2Y(4) nucleotide receptor: a novel actor in post-natal cardiac development. Angiogenesis. 15: 349-60. PMID 22437266 DOI: 10.1007/S10456-012-9265-1  0.77
2012 Muller C, Caillard S, Jesel L, El Ghannudi S, Ohlmann P, Sauleau E, Hannedouche T, Gachet C, Moulin B, Morel O. Association of estimated GFR with platelet inhibition in patients treated with clopidogrel. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation. 59: 777-85. PMID 22425260 DOI: 10.1053/J.Ajkd.2011.12.027  0.378
2012 Schaff M, Receveur N, Bourdon C, Ohlmann P, Lanza F, Gachet C, Mangin PH. β-arrestin-1 participates in thrombosis and regulates integrin aIIbβ3 signalling without affecting P2Y receptors desensitisation and function. Thrombosis and Haemostasis. 107: 735-48. PMID 22318609 DOI: 10.1160/Th11-06-0430  0.341
2012 Mangin PH, Tang C, Bourdon C, Loyau S, Freund M, Hechler B, Gachet C, Jandrot-Perrus M. A humanized glycoprotein VI (GPVI) mouse model to assess the antithrombotic efficacies of anti-GPVI agents. The Journal of Pharmacology and Experimental Therapeutics. 341: 156-63. PMID 22238212 DOI: 10.1124/Jpet.111.189050  0.68
2012 Léon C, Evert K, Dombrowski F, Pertuy F, Eckly A, Laeuffer P, Gachet C, Greinacher A. Romiplostim administration shows reduced megakaryocyte response-capacity and increased myelofibrosis in a mouse model of MYH9-RD. Blood. 119: 3333-41. PMID 22234693 DOI: 10.1182/Blood-2011-08-373811  0.366
2012 Strassel C, Eckly A, Léon C, Moog S, Cazenave JP, Gachet C, Lanza F. Hirudin and heparin enable efficient megakaryocyte differentiation of mouse bone marrow progenitors. Experimental Cell Research. 318: 25-32. PMID 22008103 DOI: 10.1016/J.Yexcr.2011.10.003  0.385
2012 Andriamampandry MD, Leray C, Gutbier G, Freund M, Cassel D, Cazenave JP, Gachet C. Diets rich in saturated n-9 and n-3 fatty acids differentially affect the fatty acid composition of phospholipids and function of rat platelets. Platelets. 7: 269-76. PMID 21043661 DOI: 10.3109/09537109609023588  0.333
2012 Gachet C, Hechler B, Léon C, Vial C, Ohlmann P, Cazenave JP. Purinergic receptors on blood platelets. Platelets. 7: 261-7. PMID 21043660 DOI: 10.3109/09537109609023587  0.839
2012 Gachet C, Léon C, Hechler B. Corrigendum to “The platelet P2 receptors in arterial thrombosis” [Blood Cells Mol. Dis. 36 (2006) 223–227] Blood Cells, Molecules, and Diseases. 49: 120. DOI: 10.1016/J.Bcmd.2012.05.013  0.709
2011 Hechler B, Gachet C. P2 receptors and platelet function. Purinergic Signalling. 7: 293-303. PMID 21792575 DOI: 10.1007/S11302-011-9247-6  0.763
2011 Zerr M, Hechler B, Freund M, Magnenat S, Lanois I, Cazenave JP, Léon C, Gachet C. Major contribution of the P2Y₁receptor in purinergic regulation of TNFα-induced vascular inflammation. Circulation. 123: 2404-13. PMID 21576651 DOI: 10.1161/Circulationaha.110.002139  0.643
2011 Hechler B, Freund M, Alame G, Leguay C, Gaertner S, Cazenave JP, Petitou M, Gachet C. The antithrombotic activity of EP224283, a neutralizable dual factor Xa inhibitor/glycoprotein IIbIIIa antagonist, exceeds that of the coadministered parent compounds. The Journal of Pharmacology and Experimental Therapeutics. 338: 412-20. PMID 21527535 DOI: 10.1124/Jpet.111.181321  0.653
2011 El Ghannudi S, Ohlmann P, Jesel L, Radulescu B, El Adraa E, Crimizade U, Wiesel ML, Gachet C, Morel O. Impaired inhibition of P2Y(12) by clopidogrel is a major determinant of cardiac death in diabetes mellitus patients treated by percutaneous coronary intervention. Atherosclerosis. 217: 465-72. PMID 21524751 DOI: 10.1016/J.Atherosclerosis.2011.03.039  0.332
2011 Hechler B, Gachet C. Comparison of two murine models of thrombosis induced by atherosclerotic plaque injury. Thrombosis and Haemostasis. 105: S3-12. PMID 21479341 DOI: 10.1160/Ths10-11-0730  0.659
2011 Eckly A, Hechler B, Freund M, Zerr M, Cazenave JP, Lanza F, Mangin PH, Gachet C. Mechanisms underlying FeCl3-induced arterial thrombosis. Journal of Thrombosis and Haemostasis : Jth. 9: 779-89. PMID 21261806 DOI: 10.1111/J.1538-7836.2011.04218.X  0.601
2011 Morel O, El Ghannudi S, Jesel L, Radulescu B, Meyer N, Wiesel ML, Caillard S, Campia U, Moulin B, Gachet C, Ohlmann P. Cardiovascular mortality in chronic kidney disease patients undergoing percutaneous coronary intervention is mainly related to impaired P2Y12 inhibition by clopidogrel. Journal of the American College of Cardiology. 57: 399-408. PMID 21251579 DOI: 10.1016/J.Jacc.2010.09.032  0.324
2011 Schaff M, Receveur N, Bourdon C, Wurtz V, Denis CV, Orend G, Gachet C, Lanza F, Mangin PH. Novel function of tenascin-C, a matrix protein relevant to atherosclerosis, in platelet recruitment and activation under flow. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 117-24. PMID 20651280 DOI: 10.1161/Atvbaha.110.206375  0.408
2011 Bluteau D, Lordier L, Antony-Debré I, Jalil A, Legrand C, Rameau P, Bluteau O, Jouni D, Mercher T, Leon C, Gachet C, Debili N, Vainchenker W, Chang Y, Raslova H. RUNX1-Induced Silencing of Non-Muscle Myosin Iib (MYH10) Is Required for Megakaryocyte Polyploidization Blood. 118: 1308-1308. DOI: 10.1182/Blood.V118.21.1308.1308  0.348
2010 Bonello L, Tantry US, Marcucci R, Blindt R, Angiolillo DJ, Becker R, Bhatt DL, Cattaneo M, Collet JP, Cuisset T, Gachet C, Montalescot G, Jennings LK, Kereiakes D, Sibbing D, et al. Consensus and future directions on the definition of high on-treatment platelet reactivity to adenosine diphosphate. Journal of the American College of Cardiology. 56: 919-33. PMID 20828644 DOI: 10.1016/J.Jacc.2010.04.047  0.434
2010 Eckly A, Rinckel JY, Laeuffer P, Cazenave JP, Lanza F, Gachet C, Léon C. Proplatelet formation deficit and megakaryocyte death contribute to thrombocytopenia in Myh9 knockout mice. Journal of Thrombosis and Haemostasis : Jth. 8: 2243-51. PMID 20695978 DOI: 10.1111/J.1538-7836.2010.04009.X  0.305
2010 Maître B, Mangin PH, Eckly A, Heim V, Cazenave JP, Lanza F, Hanau D, Gachet C. Immature myeloid dendritic cells capture and remove activated platelets from preformed aggregates. Journal of Thrombosis and Haemostasis : Jth. 8: 2262-72. PMID 20633211 DOI: 10.1111/J.1538-7836.2010.03983.X  0.4
2010 El Ghannudi S, Ohlmann P, Meyer N, Wiesel ML, Radulescu B, Chauvin M, Bareiss P, Gachet C, Morel O. Impact of P2Y12 inhibition by clopidogrel on cardiovascular mortality in unselected patients treated by percutaneous coronary angioplasty: a prospective registry. Jacc. Cardiovascular Interventions. 3: 648-56. PMID 20630458 DOI: 10.1016/J.Jcin.2010.03.003  0.358
2010 Ohlmann P, de Castro S, Brown GG, Gachet C, Jacobson KA, Harden TK. Quantification of recombinant and platelet P2Y(1) receptors utilizing a [(125)I]-labeled high-affinity antagonist 2-iodo-N(6)-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate ([(125)I]MRS2500). Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 62: 344-51. PMID 20594939 DOI: 10.1016/J.Phrs.2010.05.007  0.522
2010 de Castro S, Maruoka H, Hong K, Kilbey SM, Costanzi S, Hechler B, Brown GG, Gachet C, Harden TK, Jacobson KA. Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier. Bioconjugate Chemistry. 21: 1190-205. PMID 20565071 DOI: 10.1021/Bc900569U  0.677
2010 Bender M, Eckly A, Hartwig JH, Elvers M, Pleines I, Gupta S, Krohne G, Jeanclos E, Gohla A, Gurniak C, Gachet C, Witke W, Nieswandt B. ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing. Blood. 116: 1767-75. PMID 20530287 DOI: 10.1182/Blood-2010-03-274340  0.447
2010 Ravanat C, Strassel C, Hechler B, Schuhler S, Chicanne G, Payrastre B, Gachet C, Lanza F. A central role of GPIb-IX in the procoagulant function of platelets that is independent of the 45-kDa GPIbalpha N-terminal extracellular domain. Blood. 116: 1157-64. PMID 20457869 DOI: 10.1182/Blood-2010-01-266080  0.717
2010 Laplante MA, Monassier L, Freund M, Bousquet P, Gachet C. The purinergic P2Y1 receptor supports leptin secretion in adipose tissue Endocrinology. 151: 2060-2070. PMID 20185765 DOI: 10.1210/En.2009-1134  0.376
2010 Pleines I, Eckly A, Elvers M, Hagedorn I, Eliautou S, Bender M, Wu X, Lanza F, Gachet C, Brakebusch C, Nieswandt B. Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. Blood. 115: 3364-73. PMID 20139097 DOI: 10.1182/Blood-2009-09-242271  0.534
2010 Hechler B, Nonne C, Eckly A, Magnenat S, Rinckel JY, Denis CV, Freund M, Cazenave JP, Lanza F, Gachet C. Arterial thrombosis: relevance of a model with two levels of severity assessed by histologic, ultrastructural and functional characterization. Journal of Thrombosis and Haemostasis : Jth. 8: 173-84. PMID 19874458 DOI: 10.1111/J.1538-7836.2009.03666.X  0.648
2010 David T, Strassel C, Eckly A, Cazenave JP, Gachet C, Lanza F. The platelet glycoprotein GPIbbeta intracellular domain participates in von Willebrand factor induced-filopodia formation independently of the Ser 166 phosphorylation site. Journal of Thrombosis and Haemostasis : Jth. 8: 1077-87. PMID 19694944 DOI: 10.1111/J.1538-7836.2009.03590.X  0.441
2009 Eliautou S, Mangin PH, Walter U, Gachet C, Lanza F. Normal filopodia extension in VASP-deficient platelets upon activation by adhesive matrices or soluble agonists. Thrombosis and Haemostasis. 102: 792-4. PMID 19806269 DOI: 10.1160/Th09-06-0379  0.49
2009 Kim Y, Hechler B, Gao ZG, Gachet C, Jacobson KA. PEGylated dendritic unimolecular micelles as versatile carriers for ligands of G protein-coupled receptors. Bioconjugate Chemistry. 20: 1888-98. PMID 19785401 DOI: 10.1021/Bc9001689  0.656
2009 Reiner S, Ziegler N, Leon C, Lorenz K, von Hayn K, Gachet C, Lohse MJ, Hoffmann C. beta-Arrestin-2 interaction and internalization of the human P2Y1 receptor are dependent on C-terminal phosphorylation sites. Molecular Pharmacology. 76: 1162-71. PMID 19741005 DOI: 10.1124/Mol.109.060467  0.371
2009 Strassel C, Hechler B, Bull A, Gachet C, Lanza F. Studies of mice lacking the GPIb-V-IX complex question the role of this receptor in atherosclerosis. Journal of Thrombosis and Haemostasis : Jth. 7: 1935-8. PMID 19740100 DOI: 10.1111/J.1538-7836.2009.03608.X  0.691
2009 Mangin PH, Receveur N, Wurtz V, David T, Gachet C, Lanza F. Identification of five novel 14-3-3 isoforms interacting with the GPIb-IX complex in platelets. Journal of Thrombosis and Haemostasis : Jth. 7: 1550-5. PMID 19558434 DOI: 10.1111/J.1538-7836.2009.03530.X  0.401
2009 Grimm I, Messemer N, Stanke M, Gachet C, Zimmermann H. Coordinate pathways for nucleotide and EGF signaling in cultured adult neural progenitor cells. Journal of Cell Science. 122: 2524-33. PMID 19549686 DOI: 10.1242/Jcs.044891  0.342
2009 Strassel C, Eckly A, Léon C, Petitjean C, Freund M, Cazenave JP, Gachet C, Lanza F. Intrinsic impaired proplatelet formation and microtubule coil assembly of megakaryocytes in a mouse model of Bernard-Soulier syndrome. Haematologica. 94: 800-10. PMID 19377075 DOI: 10.3324/Haematol.2008.001032  0.48
2009 Mangin PH, Kleitz L, Boucheix C, Gachet C, Lanza F. CD9 negatively regulates integrin alphaIIbbeta3 activation and could thus prevent excessive platelet recruitment at sites of vascular injury. Journal of Thrombosis and Haemostasis : Jth. 7: 900-2. PMID 19228283 DOI: 10.1111/J.1538-7836.2009.03322.X  0.351
2009 Smyth SS, Woulfe DS, Weitz JI, Gachet C, Conley PB, Goodman SG, Roe MT, Kuliopulos A, Moliterno DJ, French PA, Steinhubl SR, Becker RC. G-protein-coupled receptors as signaling targets for antiplatelet therapy. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 449-57. PMID 19023091 DOI: 10.1161/Atvbaha.108.176388  0.467
2009 Eckly A, Strassel C, Freund M, Cazenave JP, Lanza F, Gachet C, Léon C. Abnormal megakaryocyte morphology and proplatelet formation in mice with megakaryocyte-restricted MYH9 inactivation. Blood. 113: 3182-9. PMID 18984861 DOI: 10.1182/Blood-2008-06-164061  0.348
2009 Kim Y, Klutz AM, Hechler B, Gao ZG, Gachet C, Jacobson KA. Application of the functionalized congener approach to dendrimer-based signaling agents acting through A(2A) adenosine receptors. Purinergic Signalling. 5: 39-50. PMID 18600474 DOI: 10.1007/S11302-008-9113-3  0.659
2008 Aleil B, Kessler L, Meyer N, Wiesel ML, Simeoni J, Cazenave JP, Pinget M, Gachet C, Lanza F. Plasma levels of soluble platelet glycoprotein V are linked to fasting blood glucose in patients with type 2 diabetes. Thrombosis and Haemostasis. 100: 713-5. PMID 18841299 DOI: 10.1160/Th08-04-0244  0.343
2008 Hechler B, Freund M, Ravanat C, Magnenat S, Cazenave JP, Gachet C. Reduced atherosclerotic lesions in P2Y1/apolipoprotein E double-knockout mice: the contribution of non-hematopoietic-derived P2Y1 receptors. Circulation. 118: 754-63. PMID 18663083 DOI: 10.1161/Circulationaha.108.788927  0.654
2008 Ohlmann P, Hechler B, Ravanat C, Loyau S, Herrenschmidt N, Wanert F, Jandrot-Perrus M, Gachet C. Ex vivo inhibition of thrombus formation by an anti-glycoprotein VI Fab fragment in non-human primates without modification of glycoprotein VI expression. Journal of Thrombosis and Haemostasis : Jth. 6: 1003-11. PMID 18419749 DOI: 10.1111/J.1538-7836.2008.02976.X  0.629
2008 Atterbury-Thomas AE, Leon C, Gachet C, Forsythe ID, Evans RJ. Contribution of P2Y(1) receptors to ADP signalling in mouse spinal cord cultures. Neuroscience Letters. 435: 190-3. PMID 18343032 DOI: 10.1016/J.Neulet.2008.02.034  0.372
2008 Gachet C. P2 receptors, platelet function and pharmacological implications. Thrombosis and Haemostasis. 99: 466-72. PMID 18327393 DOI: 10.1160/Th07-11-0673  0.533
2008 Gao ZG, Hechler B, Besada P, Gachet C, Jacobson KA. Caged agonist of P2Y1 and P2Y12 receptors for light-directed facilitation of platelet aggregation. Biochemical Pharmacology. 75: 1341-7. PMID 18199424 DOI: 10.1016/J.Bcp.2007.10.037  0.731
2008 Kim Y, Hechler B, Klutz AM, Gachet C, Jacobson KA. Toward multivalent signaling across G protein-coupled receptors from poly(amidoamine) dendrimers. Bioconjugate Chemistry. 19: 406-11. PMID 18176997 DOI: 10.1021/Bc700327U  0.706
2008 Gachet C, Aleil B. Testing antiplatelet therapy European Heart Journal Supplements. 10: A28-A34. DOI: 10.1093/Eurheartj/Sum081  0.385
2007 Lantz N, Hechler B, Ravanat C, Cazenave JP, Gachet C. A high concentration of ADP induces weak platelet granule secretion independently of aggregation and thromboxane A2 production. Thrombosis and Haemostasis. 98: 1145-7. PMID 18000625 DOI: 10.1160/Th07-06-0392  0.795
2007 Nonne C, Hechler B, Cazenave JP, Gachet C, Lanza F. Reassessment of in vivo thrombus formation in glycoprotein V deficient mice backcrossed on a C57Bl/6 strain. Journal of Thrombosis and Haemostasis : Jth. 6: 210-2. PMID 17988230 DOI: 10.1111/J.1538-7836.2007.02825.X  0.598
2007 Schoenwaelder SM, Ono A, Sturgeon S, Chan SM, Mangin P, Maxwell MJ, Turnbull S, Mulchandani M, Anderson K, Kauffenstein G, Rewcastle GW, Kendall J, Gachet C, Salem HH, Jackson SP. Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets. The Journal of Biological Chemistry. 282: 28648-58. PMID 17673465 DOI: 10.1074/Jbc.M704358200  0.691
2007 Léon C, Eckly A, Hechler B, Aleil B, Freund M, Ravanat C, Jourdain M, Nonne C, Weber J, Tiedt R, Gratacap MP, Severin S, Cazenave JP, Lanza F, Skoda R, ... Gachet C, et al. Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion. Blood. 110: 3183-91. PMID 17664350 DOI: 10.1182/Blood-2007-03-080184  0.734
2007 Wurtz V, Hechler B, Ohlmann P, Isola H, Schaeffer-Reiss C, Cazenave JP, Van Dorsselaer A, Gachet C. Identification of platelet factor 4 and beta-thromboglobulin by profiling and liquid chromatography tandem mass spectrometry of supernatant peptides in stored apheresis and buffy-coat platelet concentrates. Transfusion. 47: 1099-101. PMID 17524104 DOI: 10.1111/J.1537-2995.2007.01260.X  0.654
2007 Séverin S, Gratacap MP, Lenain N, Alvarez L, Hollande E, Penninger JM, Gachet C, Plantavid M, Payrastre B. Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth. The Journal of Clinical Investigation. 117: 944-52. PMID 17347685 DOI: 10.1172/Jci29967  0.5
2007 Hohenstein B, Renk S, Lang K, Daniel C, Freund M, Léon C, Amann KU, Gachet C, Hugo CP. P2Y1 gene deficiency protects from renal disease progression and capillary rarefaction during passive crescentic glomerulonephritis. Journal of the American Society of Nephrology : Jasn. 18: 494-505. PMID 17215444 DOI: 10.1681/Asn.2006050439  0.335
2007 David T, Ohlmann P, Eckly A, Moog S, Cazenave JP, Gachet C, Lanza F. Inhibition of adhesive and signaling functions of the platelet GPIb-V-IX complex by a cell penetrating GPIbalpha peptide. Journal of Thrombosis and Haemostasis : Jth. 4: 2645-55. PMID 17100656 DOI: 10.1111/J.1538-7836.2006.02198.X  0.471
2007 Leray C, Freund M, Wiesel ML, Gutbier G, Cazenave JP, Gachet C. Effects of clopidogrel and its inactive form, SR 25989, on plasma, liver and platelet lipids in the rat. Platelets. 9: 49-54. PMID 16793745 DOI: 10.1080/09537109877004  0.414
2007 Hechler B, Freund M, Ravanat C, Magnenat S, Cazenave J, Gachet C. REDUCED ATHEROSCLEROTIC LESIONS IN P2Y1/APOE DOUBLE KNOCKOUT MICE Journal of Thrombosis and Haemostasis. 5: O-S-082-O-S-082. DOI: 10.1111/J.1538-7836.2007.Tb00085.X  0.594
2006 Gachet C, Hechler B, Nonne C, Cazenave JP, Lanza F, Aleil B. [Atherothrombosis: transposition of the models to the clinic and reciprocally]. Therapie. 61: 389-94. PMID 17243267 DOI: 10.2515/Therapie:2006067  0.622
2006 Strassel C, Nonne C, Eckly A, David T, Leon C, Freund M, Cazenave JP, Gachet C, Lanza F. Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 241-7. PMID 17095718 DOI: 10.1161/01.Atv.0000251992.47053.75  0.399
2006 Aleil B, Meyer N, Wolff V, Kientz D, Wiesel ML, Gachet C, Cazenave JP, Lanza F. Plasma glycoprotein V levels in the general population: normal distribution, associated parameters and implications for clinical studies. Thrombosis and Haemostasis. 96: 505-11. PMID 17003930 DOI: 10.1160/Th06-06-0296  0.343
2006 Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Knight GE, Fumagalli M, Gachet C, Jacobson KA, Weisman GA. International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacological Reviews. 58: 281-341. PMID 16968944 DOI: 10.1124/Pr.58.3.3  0.4
2006 Arthur JF, Shen Y, Mu FT, Leon C, Gachet C, Berndt MC, Andrews RK. Calmodulin interacts with the platelet ADP receptor P2Y1. The Biochemical Journal. 398: 339-43. PMID 16848759 DOI: 10.1042/Bj20060822  0.503
2006 Schulte V, Reusch HP, Pozgajová M, Varga-Szabó D, Gachet C, Nieswandt B. Two-phase antithrombotic protection after anti-glycoprotein VI treatment in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 1640-7. PMID 16675723 DOI: 10.1161/01.Atv.0000225697.98093.Ed  0.51
2006 Lesurtel M, Graf R, Aleil B, Walther DJ, Tian Y, Jochum W, Gachet C, Bader M, Clavien PA. Platelet-derived serotonin mediates liver regeneration. Science (New York, N.Y.). 312: 104-7. PMID 16601191 DOI: 10.1126/Science.1123842  0.396
2006 Gachet C, Léon C, Hechler B. The platelet P2 receptors in arterial thrombosis. Blood Cells, Molecules & Diseases. 36: 223-7. PMID 16466948 DOI: 10.1016/J.Bcmd.2005.12.024  0.721
2006 Mishra SK, Braun N, Shukla V, Füllgrabe M, Schomerus C, Korf HW, Gachet C, Ikehara Y, Sévigny J, Robson SC, Zimmermann H. Extracellular nucleotide signaling in adult neural stem cells: synergism with growth factor-mediated cellular proliferation. Development (Cambridge, England). 133: 675-84. PMID 16436623 DOI: 10.1242/Dev.02233  0.375
2006 Gachet C. Regulation of platelet functions by P2 receptors. Annual Review of Pharmacology and Toxicology. 46: 277-300. PMID 16402906 DOI: 10.1146/Annurev.Pharmtox.46.120604.141207  0.562
2006 Hechler B, Nonne C, Roh EJ, Cattaneo M, Cazenave JP, Lanza F, Jacobson KA, Gachet C. MRS2500 [2-iodo-N6-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate], a potent, selective, and stable antagonist of the platelet P2Y1 receptor with strong antithrombotic activity in mice. The Journal of Pharmacology and Experimental Therapeutics. 316: 556-63. PMID 16236815 DOI: 10.1124/Jpet.105.094037  0.746
2006 Jacquet S, Malaval C, Martinez LO, Sak K, Rolland C, Perez C, Nauze M, Champagne E, Tercé F, Gachet C, Perret B, Collet X, Boeynaems JM, Barbaras R. The nucleotide receptor P2Y13 is a key regulator of hepatic high-density lipoprotein (HDL) endocytosis. Cellular and Molecular Life Sciences : Cmls. 62: 2508-15. PMID 16231090 DOI: 10.1007/S00018-005-5194-0  0.369
2006 Ohlmann P, Lanza F, Gachet C. Further evidence that fibrillar collagen is unable to promote platelet shape change and aggregation in the absence of secondary agonists. Reply to a rebuttal [19] Journal of Thrombosis and Haemostasis. 4: 292-293. DOI: 10.1111/J.1538-7836.2005.01713.X  0.473
2006 Gachet C. Mo-W10:2 Purinergic regulation of platelet function Atherosclerosis Supplements. 7: 28-29. DOI: 10.1016/S1567-5688(06)80083-8  0.334
2005 Léon C, Freund M, Latchoumanin O, Farret A, Petit P, Cazenave JP, Gachet C. The P2Y(1) receptor is involved in the maintenance of glucose homeostasis and in insulin secretion in mice. Purinergic Signalling. 1: 145-51. PMID 18404499 DOI: 10.1007/S11302-005-6209-X  0.319
2005 Soulet C, Hechler B, Gratacap MP, Plantavid M, Offermanns S, Gachet C, Payrastre B. A differential role of the platelet ADP receptors P2Y1 and P2Y12 in Rac activation. Journal of Thrombosis and Haemostasis : Jth. 3: 2296-306. PMID 16194206 DOI: 10.1111/J.1538-7836.2005.01588.X  0.715
2005 Ohlmann P, Eckly A, Mangin P, Lanza F, Gachet C. Further evidence that fibrillar collagen is unable to promote platelet shape change and aggregation in the absence of secondary agonists. Journal of Thrombosis and Haemostasis : Jth. 3: 2119-21. PMID 16102128 DOI: 10.1111/j.1538-7836.2005.01490.x  0.369
2005 Gachet C. The platelet P2 receptors as molecular targets for old and new antiplatelet drugs. Pharmacology & Therapeutics. 108: 180-92. PMID 15955565 DOI: 10.1016/J.Pharmthera.2005.03.009  0.536
2005 Cazenave JP, Isola H, Gachet C, Aleil B. [Progress in transfusion for storage of platelets]. Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine. 12: 226-9. PMID 15950893 DOI: 10.1016/J.Tracli.2005.04.027  0.449
2005 Tolhurst G, Vial C, Léon C, Gachet C, Evans RJ, Mahaut-Smith MP. Interplay between P2Y(1), P2Y(12), and P2X(1) receptors in the activation of megakaryocyte cation influx currents by ADP: evidence that the primary megakaryocyte represents a fully functional model of platelet P2 receptor signaling. Blood. 106: 1644-51. PMID 15914557 DOI: 10.1182/Blood-2005-02-0725  0.765
2005 Gachet C, Hechler B. The platelet P2 receptors in thrombosis. Seminars in Thrombosis and Hemostasis. 31: 162-7. PMID 15852219 DOI: 10.1055/S-2005-869521  0.719
2005 Hechler B, Cattaneo M, Gachet C. The P2 receptors in platelet function. Seminars in Thrombosis and Hemostasis. 31: 150-61. PMID 15852218 DOI: 10.1055/S-2005-869520  0.763
2005 Hechler B, Magnenat S, Zighetti ML, Kassack MU, Ullmann H, Cazenave JP, Evans R, Cattaneo M, Gachet C. Inhibition of platelet functions and thrombosis through selective or nonselective inhibition of the platelet P2 receptors with increasing doses of NF449 [4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis-(carbonylimino)))tetrakis-benzene-1,3-disulfonic acid octasodium salt]. The Journal of Pharmacology and Experimental Therapeutics. 314: 232-43. PMID 15792995 DOI: 10.1124/Jpet.105.084673  0.737
2005 Nonne C, Lenain N, Hechler B, Mangin P, Cazenave JP, Gachet C, Lanza F. Importance of platelet phospholipase Cgamma2 signaling in arterial thrombosis as a function of lesion severity. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 1293-8. PMID 15774906 DOI: 10.1161/01.Atv.0000163184.02484.69  0.723
2005 Bodin S, Soulet C, Tronchère H, Sié P, Gachet C, Plantavid M, Payrastre B. Integrin-dependent interaction of lipid rafts with the actin cytoskeleton in activated human platelets. Journal of Cell Science. 118: 759-69. PMID 15671066 DOI: 10.1242/Jcs.01648  0.457
2005 Aleil B, Ravanat C, Cazenave JP, Rochoux G, Heitz A, Gachet C. Flow cytometric analysis of intraplatelet VASP phosphorylation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases. Journal of Thrombosis and Haemostasis : Jth. 3: 85-92. PMID 15634270 DOI: 10.1111/J.1538-7836.2004.01063.X  0.466
2005 Abbracchio MP, Burnstock G, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Miras-Portugal MT, King BF, Gachet C, Jacobson KA, Weisman GA. The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor. Trends in Pharmacological Sciences. 26: 8-9. PMID 15629198 DOI: 10.1016/J.Tips.2004.10.010  0.385
2005 Baurand A, Eckly A, Hechler B, Kauffenstein G, Galzi JL, Cazenave JP, Léon C, Gachet C. Differential regulation and relocalization of the platelet P2Y receptors after activation: a way to avoid loss of hemostatic properties? Molecular Pharmacology. 67: 721-33. PMID 15602005 DOI: 10.1124/Mol.104.004846  0.832
2005 Kauffenstein G, Hechler B, Cazenave JP, Gachet C. Adenine triphosphate nucleotides are antagonists at the P2Y receptor. Journal of Thrombosis and Haemostasis : Jth. 2: 1980-8. PMID 15550030 DOI: 10.1111/J.1538-7836.2004.00926.X  0.821
2005 Martinez-Pinna J, Gurung IS, Vial C, Leon C, Gachet C, Evans RJ, Mahaut-Smith MP. Direct voltage control of signaling via P2Y1 and other Galphaq-coupled receptors. The Journal of Biological Chemistry. 280: 1490-8. PMID 15528188 DOI: 10.1074/jbc.M407783200  0.684
2005 Mangin P, Ohlmann P, Eckly A, Cazenave JP, Lanza F, Gachet C. The P2Y1 receptor plays an essential role in the platelet shape change induced by collagen when TxA2 formation is prevented. Journal of Thrombosis and Haemostasis : Jth. 2: 969-77. PMID 15140133 DOI: 10.1111/J.1538-7836.2004.00722.X  0.558
2004 Kawamura M, Gachet C, Inoue K, Kato F. Direct excitation of inhibitory interneurons by extracellular ATP mediated by P2Y1 receptors in the hippocampal slice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10835-45. PMID 15574734 DOI: 10.1523/Jneurosci.3028-04.2004  0.389
2004 Calvert JA, Atterbury-Thomas AE, Leon C, Forsythe ID, Gachet C, Evans RJ. Evidence for P2Y1, P2Y2, P2Y6 and atypical UTP-sensitive receptors coupled to rises in intracellular calcium in mouse cultured superior cervical ganglion neurons and glia. British Journal of Pharmacology. 143: 525-32. PMID 15466449 DOI: 10.1038/Sj.Bjp.0705959  0.368
2004 Ohlmann P, Hechler B, Cazenave JP, Gachet C. Measurement and manipulation of [Ca2+]i in suspensions of platelets and cell cultures. Methods in Molecular Biology (Clifton, N.J.). 273: 229-50. PMID 15308805 DOI: 10.1385/1-59259-783-1:229  0.649
2004 Cazenave JP, Ohlmann P, Cassel D, Eckly A, Hechler B, Gachet C. Preparation of washed platelet suspensions from human and rodent blood. Methods in Molecular Biology (Clifton, N.J.). 272: 13-28. PMID 15226531 DOI: 10.1385/1-59259-782-3:013  0.706
2004 Mangin P, David T, Lavaud V, Cranmer SL, Pikovski I, Jackson SP, Berndt MC, Cazenave JP, Gachet C, Lanza F. Identification of a novel 14-3-3zeta binding site within the cytoplasmic tail of platelet glycoprotein Ibalpha. Blood. 104: 420-7. PMID 15054037 DOI: 10.1182/Blood-2003-08-2881  0.383
2004 Mathieu R, Baurand A, Schmitt M, Gachet C, Bourguignon JJ. Synthesis and biological activity of 2-alkylated deoxyadenosine bisphosphate derivatives as P2Y(1) receptor antagonists. Bioorganic & Medicinal Chemistry. 12: 1769-79. PMID 15028267 DOI: 10.1016/J.Bmc.2003.12.041  0.43
2004 Lecut C, Feeney LA, Kingsbury G, Hopkins J, Lanza F, Gachet C, Villeval JL, Jandrot-Perrus M. Human platelet glycoprotein VI function is antagonized by monoclonal antibody-derived Fab fragments. Journal of Thrombosis and Haemostasis : Jth. 1: 2653-62. PMID 14675102 DOI: 10.1111/J.1538-7836.2003.00495.X  0.506
2004 Haserück N, Erl W, Pandey D, Tigyi G, Ohlmann P, Ravanat C, Gachet C, Siess W. The plaque lipid lysophosphatidic acid stimulates platelet activation and platelet-monocyte aggregate formation in whole blood: involvement of P2Y1 and P2Y12 receptors. Blood. 103: 2585-92. PMID 14645014 DOI: 10.1182/Blood-2003-04-1127  0.54
2004 Leon C, Alex M, Klocke A, Morgenstern E, Moosbauer C, Eckly A, Spannagl M, Gachet C, Engelmann B. Platelet ADP receptors contribute to the initiation of intravascular coagulation. Blood. 103: 594-600. PMID 12969982 DOI: 10.1182/Blood-2003-05-1385  0.56
2004 Lenain N, Freund M, Léon C, Cazenave JP, Gachet C. Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist. Journal of Thrombosis and Haemostasis : Jth. 1: 1144-9. PMID 12871312 DOI: 10.1046/J.1538-7836.2003.00144.X  0.441
2003 Leon C, Ravanat C, Freund M, Cazenave JP, Gachet C. Differential involvement of the P2Y1 and P2Y12 receptors in platelet procoagulant activity. Arteriosclerosis, Thrombosis, and Vascular Biology. 23: 1941-7. PMID 12933533 DOI: 10.1161/01.Atv.0000092127.16125.E6  0.542
2003 Hechler B, Lenain N, Marchese P, Vial C, Heim V, Freund M, Cazenave JP, Cattaneo M, Ruggeri ZM, Evans R, Gachet C. A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo. The Journal of Experimental Medicine. 198: 661-7. PMID 12913094 DOI: 10.1084/Jem.20030144  0.83
2003 Hechler B, Zhang Y, Eckly A, Cazenave JP, Gachet C, Ravid K. Lineage-specific overexpression of the P2Y 1 receptor induces platelet hyper-reactivity in transgenic mice Journal of Thrombosis and Haemostasis. 1: 155-163. PMID 12871553 DOI: 10.1046/j.1538-7836.2003.00003.x  0.747
2003 Moriyama T, Iida T, Kobayashi K, Higashi T, Fukuoka T, Tsumura H, Leon C, Suzuki N, Inoue K, Gachet C, Noguchi K, Tominaga M. Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 6058-62. PMID 12853424 DOI: 10.1523/Jneurosci.23-14-06058.2003  0.393
2003 Mangin P, Yuan Y, Goncalves I, Eckly A, Freund M, Cazenave JP, Gachet C, Jackson SP, Lanza F. Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA. The Journal of Biological Chemistry. 278: 32880-91. PMID 12813055 DOI: 10.1074/jbc.M302333200  0.393
2003 Mangin P, Nonne C, Eckly A, Ohlmann P, Freund M, Nieswandt B, Cazenave JP, Gachet C, Lanza F. A PLCγ2‐independent platelet collagen aggregation requiring functional association of GPVI and integrin α2β1 Febs Letters. 542: 53-59. PMID 12729897 DOI: 10.1016/S0014-5793(03)00337-5  0.521
2003 Baurand A, Gachet C. The P2Y(1) receptor as a target for new antithrombotic drugs: a review of the P2Y(1) antagonist MRS-2179. Cardiovascular Drug Reviews. 21: 67-76. PMID 12595918 DOI: 10.1111/J.1527-3466.2003.Tb00106.X  0.477
2003 Abbracchio MP, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Miras-Portugal MT, King BF, Gachet C, Jacobson KA, Weisman GA, Burnstock G. Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. Trends in Pharmacological Sciences. 24: 52-5. PMID 12559763 DOI: 10.1016/S0165-6147(02)00038-X  0.38
2003 Hechler B, Lenain N, Marchese P, Vial C, Heim V, Freund M, Cazenave J, Cattaneo M, Ruggeri Z, Evans R, Gachet C. A key role of the fast ATP-gated P2X1cation channel in the thrombosis of small arteriesin vivo Journal of Thrombosis and Haemostasis. 1: OC209-OC209. DOI: 10.1111/J.1538-7836.2003.Tb04596.X  0.743
2002 Raboisson P, Baurand A, Cazenave JP, Gachet C, Schultz D, Spiess B, Bourguignon JJ. A general approach toward the synthesis of C-nucleoside pyrazolo[1,5-a]-1,3,5-triazines and their 3',5'-bisphosphate C-nucleotide analogues as the first reported in vivo stable P2Y(1)-receptor antagonists. The Journal of Organic Chemistry. 67: 8063-71. PMID 12423133 DOI: 10.1021/Jo026268L  0.375
2002 Cattaneo M, Gachet C, Cazenave JP, Packham MA, Jin J, Quinton TM, Zhang J, Rittenhouse SE, Kunapuli SP. Adenosine diphosphate (ADP) does not induce thromboxane A2 generation in human platelets [2] (multiple letters) Blood. 99: 3868-3870. PMID 12014368 DOI: 10.1182/blood-2002-01-0313  0.301
2002 Leray C, Cazenave JP, Gachet C. Platelet phospholipids are differentially protected against oxidative degradation by plasmalogens. Lipids. 37: 285-90. PMID 11942479 DOI: 10.1007/S11745-002-0892-4  0.333
2002 Raboisson P, Baurand A, Cazenave JP, Gachet C, Retat M, Spiess B, Bourguignon JJ. Novel antagonists acting at the P2Y(1) purinergic receptor: synthesis and conformational analysis using potentiometric and nuclear magnetic resonance titration techniques. Journal of Medicinal Chemistry. 45: 962-72. PMID 11831909 DOI: 10.1021/Jm0104062  0.388
2002 Gachet C. Identification, characterization, and inhibition of the platelet ADP receptors. International Journal of Hematology. 74: 375-81. PMID 11794691 DOI: 10.1007/Bf02982079  0.538
2002 Boeynaems J, Communi D, Suarez Gonzalez N, Hechler B, Léon C, Gachet C. Les récepteurs P2Y des nucléotides extracellulaires : du clonage à la physiologie MéDecine/Sciences. 18: 965-973. DOI: 10.1051/Medsci/20021810965  0.581
2001 Hechler B, Toselli P, Ravanat C, Gachet C, Ravid K. Mpl ligand increases P2Y1 receptor gene expression in megakaryocytes with no concomitant change in platelet response to ADP Molecular Pharmacology. 60: 1112-1120. PMID 11641440 DOI: 10.1124/Mol.60.5.1112  0.711
2001 Kauffenstein G, Bergmeier W, Eckly A, Ohlmann P, Léon C, Cazenave JP, Nieswandt B, Gachet C. The P2Y12 receptor induces platelet aggregation through weak activation of the αIIbβ3 integrin – a phosphoinositide 3‐kinase‐dependent mechanism Febs Letters. 505: 281-290. PMID 11566191 DOI: 10.1016/S0014-5793(01)02824-1  0.772
2001 Moog S, Mangin P, Lenain N, Strassel C, Ravanat C, Schuhler S, Freund M, Santer M, Kahn M, Nieswandt B, Gachet C, Cazenave JP, Lanza F. Platelet glycoprotein V binds to collagen and participates in platelet adhesion and aggregation. Blood. 98: 1038-46. PMID 11493449 DOI: 10.1182/Blood.V98.4.1038  0.523
2001 Nieswandt B, Bergmeier W, Eckly A, Schulte V, Ohlmann P, Cazenave JP, Zirngibl H, Offermanns S, Gachet C. Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation. Blood. 97: 3829-35. PMID 11389023 DOI: 10.1182/BLOOD.V97.12.3829  0.474
2001 Nieswandt B, Schulte V, Bergmeier W, Mokhtari-Nejad R, Rackebrandt K, Cazenave JP, Ohlmann P, Gachet C, Zirngibl H. Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice. The Journal of Experimental Medicine. 193: 459-69. PMID 11181698 DOI: 10.1084/Jem.193.4.459  0.526
2001 Baurand A, Raboisson P, Freund M, Léon C, Cazenave JP, Bourguignon JJ, Gachet C. Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist. European Journal of Pharmacology. 412: 213-21. PMID 11166284 DOI: 10.1016/S0014-2999(01)00733-6  0.56
2001 Léon C, Freund M, Ravanat C, Baurand A, Cazenave JP, Gachet C. Key role of the P2Y(1) receptor in tissue factor-induced thrombin-dependent acute thromboembolism: studies in P2Y(1)-knockout mice and mice treated with a P2Y(1) antagonist. Circulation. 103: 718-23. PMID 11156884 DOI: 10.1161/01.Cir.103.5.718  0.482
2001 Gachet C. ADP Receptors of Platelets and their Inhibition Thrombosis and Haemostasis. 86: 222-232. DOI: 10.1055/S-0037-1616220  0.538
2001 Eckly A, Gendrault J, Hechler B, Cazenave J, Gachet C. Differential Involvement of the P2Y1 and P2YT Receptors in the Morphological Changes of Platelet Aggregation Thrombosis and Haemostasis. 85: 694-701. DOI: 10.1055/S-0037-1615655  0.753
2000 Fayolle C, Leray C, Ohlmann P, Gutbier G, Cazenave JP, Gachet C, Groscolas R. Lipid composition of blood platelets and erythrocytes of southern elephant seal (Mirounga leonina) and antarctic fur seal (Arctocephalus gazella). Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 126: 39-47. PMID 10825663 DOI: 10.1016/S0305-0491(00)00175-9  0.359
2000 Léon C, Hechler B, Freund M, Eckly A, Vial C, Ohlmann P, Dierich A, LeMeur M, Cazenave JP, Gachet C. Defective platelet aggregation and increased resistance to thrombosis in purinergic P2Y(1) receptor-null mice. The Journal of Clinical Investigation. 104: 1731-7. PMID 10606627 DOI: 10.1172/Jci8399  0.846
2000 Ohlmann P, Eckly A, Freund M, Cazenave J, Offermanns S, Gachet C. ADP induces partial platelet aggregation without shape change and potentiates collagen-induced aggregation in the absence of Gαq Blood. 96: 2134-2139. DOI: 10.1182/BLOOD.V96.6.2134.H8002134_2134_2139  0.458
2000 Baurand A, Eckly A, Bari N, Léon C, Hechler B, Cazenave J, Gachet C. Desensitization of the Platelet Aggregation Response to ADP: Differential Down-regulation of the P2Y1 and P2cyc Receptors Thrombosis and Haemostasis. 84: 484-491. DOI: 10.1055/S-0037-1614049  0.754
1999 Cattaneo M, Gachet C. ADP receptors and clinical bleeding disorders Arteriosclerosis, Thrombosis, and Vascular Biology. 19: 2281-2285. PMID 10521355 DOI: 10.1161/01.ATV.19.10.2281  0.448
1999 Vigne P, Hechler B, Gachet C, Breittmayer JP, Frelin C. Benzoyl ATP is an antagonist of rat and human P2Y1 receptors and of platelet aggregation. Biochemical and Biophysical Research Communications. 256: 94-7. PMID 10066429 DOI: 10.1006/Bbrc.1999.9558  0.723
1999 Andriamampandry MD, Leray C, Freund M, Cazenave JP, Gachet C. Antithrombotic effects of (n-3) polyunsaturated fatty acids in rat models of arterial and venous thrombosis. Thrombosis Research. 93: 9-16. PMID 10065894 DOI: 10.1016/S0049-3848(98)00149-2  0.346
1999 Hechler B, Eckly A, Ohlmann P, Cazenave JP, Gachet C. The P2Y1 receptor, necessary but not sufficient to support full ADP-induced platelet aggregation, is not the target of the drug clopidogrel. British Journal of Haematology. 103: 858-66. PMID 9858246 DOI: 10.1046/J.1365-2141.1998.01056.X  0.748
1999 Trumel C, Payrastre B, Plantavid M, Hechler B, Viala C, Presek P, Martinson EA, Cazenave J, Chap H, Gachet C. A Key Role of Adenosine Diphosphate in the Irreversible Platelet Aggregation Induced by the PAR1-Activating Peptide Through the Late Activation of Phosphoinositide 3-Kinase Blood. 94: 4156-4165. DOI: 10.1182/Blood.V94.12.4156.424K29_4156_4165  0.729
1999 Léon C, Vial C, Ohlmann P, Hechler B, Cazenave J, Lecchi A, Cattaneo M, Gachet C. The P2Y1 Receptor Is Normal in a Patient Presenting a Severe Deficiency of ADP-induced Platelet Aggregation Thrombosis and Haemostasis. 81: 775-781. DOI: 10.1055/S-0037-1614570  0.843
1998 Ohlmann P, Leray C, Ravanat C, Hallia A, Cassel D, Cazenave JP, Gachet C. cADP-ribose formation by blood platelets is not responsible for intracellular calcium mobilization. The Biochemical Journal. 431-6. PMID 9531481 DOI: 10.1042/Bj3310431  0.396
1998 Hechler B, Léon C, Vial C, Vigne P, Frelin C, Cazenave J, Gachet C. The P2Y1 Receptor Is Necessary for Adenosine 5′-Diphosphate–Induced Platelet Aggregation Blood. 92: 152-159. DOI: 10.1182/Blood.V92.1.152.413K27_152_159  0.844
1998 Hechler B, Vigne P, Léon C, Breittmayer J, Gachet C, Frelin C. ATP Derivatives Are Antagonists of the P2Y1 Receptor: Similarities to the Platelet ADP Receptor Molecular Pharmacology. 53: 727-733. DOI: 10.1124/Mol.53.4.727  0.697
1997 Cazenave JP, Gachet C. Anti-platelet drugs: do they affect megakaryocytes? Bailliere's Clinical Haematology. 10: 163-80. PMID 9154321 DOI: 10.1016/S0950-3536(97)80056-X  0.533
1997 Léon C, Hechler B, Vial C, Leray C, Cazenave JP, Gachet C. The P2Y1 receptor is an ADP receptor antagonized by ATP and expressed in platelets and megakaryoblastic cells. Febs Letters. 403: 26-30. PMID 9038354 DOI: 10.1016/S0014-5793(97)00022-7  0.832
1997 Gachet C, Payrastre B, Guinebault C, Trumel C, Ohlmann P, Mauco G, Cazenave JP, Plantavid M, Chap H. Reversible translocation of phosphoinositide 3-kinase to the cytoskeleton of ADP-aggregated human platelets occurs independently of Rho A and without synthesis of phosphatidylinositol (3,4)-bisphosphate. The Journal of Biological Chemistry. 272: 4850-4. PMID 9030542 DOI: 10.1074/Jbc.272.8.4850  0.479
1997 Vial C, Hechier B, Léon C, Cazenave J, Gachet C. Presence of P2X1 Purinoceptors in Human Platelets and Megakaryoblastic Cell Lines Thrombosis and Haemostasis. 78: 1500-1504. DOI: 10.1055/S-0038-1665441  0.75
1997 Gachet C, Hechlel B, Léon C, Vial C, Leray C, Ohlmann P, Cazenave J. Activation of ADP Receptors and Platelet Function Thrombosis and Haemostasis. 78: 271-275. DOI: 10.1055/S-0038-1657538  0.783
1997 Cattaneo M, Lombardi R, Zighetti ML, Gachet C, Ohlmann P, Cazenave J, Mannucci PM. Deficiency of (33P)2MeS-ADP Binding Sites on Platelets with Secretion Defect, Normal Granule Stores and Normal Thromboxane A2 Production Thrombosis and Haemostasis. 77: 0986-0990. DOI: 10.1055/S-0038-1656090  0.511
1996 Gachet C, Ennamany R, Kretz O, Ohlmann P, Krause C, Creppy EE, Dirheimer G, Cazenave JP. Bolesatine induces agglutination of rat platelets and human erythrocytes and platelets in vitro. Human & Experimental Toxicology. 15: 26-9. PMID 8845205 DOI: 10.1177/096032719601500105  0.473
1996 Léon C, Vial C, Cazenave JP, Gachet C. Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor. Gene. 171: 295-7. PMID 8666290 DOI: 10.1016/0378-1119(96)00027-3  0.671
1996 Ohlmann P, Laugwitz KL, Nürnberg B, Spicher K, Schultz G, Cazenave JP, Gachet C. The human platelet ADP receptor activates Gi2 proteins. The Biochemical Journal. 775-9. PMID 8554519 DOI: 10.1042/Bj3120775  0.348
1996 Gachet C, Cattaneo M, Ohlmann P, Hechler B, Lecchi A, Chevalier J, Cassel D, Mannucci PM, Cazenave JP. Purinoceptors on blood platelets: further pharmacological and clinical evidence to suggest the presence of two ADP receptors. British Journal of Haematology. 91: 434-44. PMID 8547091 DOI: 10.1111/J.1365-2141.1995.Tb05319.X  0.743
1995 De La Salle C, Baas MJ, Lanza F, Schwartz A, Hanau D, Chevalier J, Gachet C, Briquel ME, Cazenave JP. A three-base deletion removing a leucine residue in a leucine-rich repeat of platelet glycoprotein Ibα associated with a variant of Bernard-Soulier syndrome (Nancy I) British Journal of Haematology. 89: 386-396. PMID 7873390 DOI: 10.1111/J.1365-2141.1995.Tb03316.X  0.438
1995 Gachet C, Astier A, de la Salle H, de la Salle C, Fridman W, Cazenave J, Hanau D, Teillaud J. Release of Fc gamma RIIa2 by activated platelets and inhibition of anti- CD9-mediated platelet aggregation by recombinant Fc gamma RIIa2 Blood. 85: 698-704. DOI: 10.1182/Blood.V85.3.698.Bloodjournal853698  0.44
1995 CAZENAVE J, GACHET C. ADP-receptor activation and platelet aggregation Pharmacological Research. 31: 291-291. DOI: 10.1016/1043-6618(95)87424-0  0.456
1994 Bischoff R, Cordier Y, Rasmussen UB, Schlesinger Y, Gachet C, Jaquinod M, Tripet B, Chong PC, Pavirani A. Synthesis and characterization of photoactivatable peptide agonists of the human thrombin receptor. Febs Letters. 349: 301-6. PMID 8050586 DOI: 10.1016/0014-5793(93)00692-B  0.357
1994 RAVANAT C, GACHET C, HERBERT J‐, SCHUHLER S, GUILLEMOT J‐, UZABIAGA F, PICARD C, FERRARA P, FREUND M, CAZENAVE J‐. Rat platelets contain glycosylated and non‐glycosylated forms of platelet factor 4: Identification and characterization by mass spectrometry European Journal of Biochemistry. 223: 203-210. PMID 8033893 DOI: 10.1111/J.1432-1033.1994.Tb18984.X  0.434
1993 Gachet C, Hanau D, Spehner D, Brisson C, Garaud JC, Schmitt DA, Ohlmann P, Cazenave JP. Alpha IIb beta 3 integrin dissociation induced by EDTA results in morphological changes of the platelet surface-connected canalicular system with differential location of the two separate subunits. The Journal of Cell Biology. 120: 1021-30. PMID 8432724 DOI: 10.1083/Jcb.120.4.1021  0.377
1993 Freund M, Mantz F, Nicolini P, Gachet C, Mulvihill J, Meyer L, Beretz A, Cazenave J. Experimental Thrombosis on a Collagen Coated Arterioarterial Shunt in Rats: A Pharmacological Model to Study Antithrombotic Agents inhibiting Thrombin Formation and Platelet Deposition Thrombosis and Haemostasis. 69: 515-521. DOI: 10.1055/S-0038-1651643  0.415
1992 Gachet C, Hanau D, Spehner D, Brisson C, Ohlmann P, Schmitt DA, Cazenave JP. Alpha IIB beta 3 integrin dissociation induced by EDTA results in formation of Birbeck granule-like structures in human blood platelets. The Journal of Investigative Dermatology. 99: 27S-29S. PMID 1431204 DOI: 10.1111/1523-1747.Ep12668284  0.484
1992 Gachet C, Cazenave JP, Ohlmann P, Hilf G, Wieland T, Jakobs KH. ADP receptor-induced activation of guanine-nucleotide-binding proteins in human platelet membranes. European Journal of Biochemistry. 207: 259-63. PMID 1321045 DOI: 10.1111/J.1432-1033.1992.Tb17046.X  0.449
1992 Gachet C, Savi P, Ohlmann P, Maffrand J, Jakobs KH, Cazenave J. ADP Receptor Induced Activation of Guanine Nucleotide Binding Proteins in Rat Platelet Membranes– An Effect Selectively Blocked by the Thienopyridine Clopidogrel Thrombosis and Haemostasis. 68: 079-083. DOI: 10.1055/s-0038-1656322  0.4
1991 Gachet C, Cazenave JP, Ohlmann P, Bouloux C, Defreyn G, Driot F, Maffrand JP. The thienopyridine ticlopidine selectively prevents the inhibitory effects of ADP but not of adrenaline on cAMP levels raised by stimulation of the adenylate cyclase of human platelets by PGE1. Biochemical Pharmacology. 40: 2683-7. PMID 2175608 DOI: 10.1016/0006-2952(90)90587-B  0.46
1991 Hanau D, Gachet C, Schmitt DA, Ohlmann P, Brisson C, Fabre M, Cazenave JP. Ultrastructural similarities between epidermal Langerhans cell Birbeck granules and the surface-connected canalicular system of EDTA-treated human blood platelets. The Journal of Investigative Dermatology. 97: 756-62. PMID 1919041 DOI: 10.1111/1523-1747.Ep12485023  0.435
1991 Defreyn G, Gachet C, Savi P, Driot F, Cazenave JP, Maffrand JP. Ticlopidine and Clopidogrel (SR 25990C) Selectively Neutralize ADP Inhibition of PGE1-Activated Platelet Adenylate Cyclase in Rats and Rabbits Thrombosis and Haemostasis. 65: 186-190. DOI: 10.1055/S-0038-1647481  0.481
1991 Gachet C, Stierlé A, Ohlmann P, Lanza F, Hanau D, Cazenave J. Normal ADP-Induced Aggregation and Absence of Dissociation of the Membrane GP IIb-IIIa Complex of Intact Rat Platelets Pretreated with EDTA Thrombosis and Haemostasis. 66: 246-253. DOI: 10.1055/S-0038-1646398  0.409
1990 Gachet C, Stierlé A, Cazenave JP, Ohlmann P, Lanza F, Bouloux C, Maffrand JP. The thienopyridine PCR 4099 selectively inhibits ADP-induced platelet aggregation and fibrinogen binding without modifying the membrane glycoprotein IIb-IIIa complex in rat and in man. Biochemical Pharmacology. 40: 229-38. PMID 2375765 DOI: 10.1016/0006-2952(90)90683-C  0.489
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