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Libin Xu - Publications

Affiliations: 
Vanderbilt University, Nashville, TN 
Area:
Free radical oxidation
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Li A, Hines KM, Xu L. Lipidomics by HILIC-Ion Mobility-Mass Spectrometry. Methods in Molecular Biology (Clifton, N.J.). 2084: 119-132. PMID 31729657 DOI: 10.1007/978-1-0716-0030-6_7  0.302
2020 Porter NA, Xu L, Pratt DA. Reactive Sterol Electrophiles: Mechanisms of Formation and Reactions with Proteins and Amino Acid Nucleophiles Chemistry. 2: 390-417. DOI: 10.3390/Chemistry2020025  0.389
2019 Seguin RP, Herron JM, Lopez V, Dempsey JL, Xu L. Metabolism of Benzalkonium Chlorides by Human Hepatic Cytochromes P450. Chemical Research in Toxicology. PMID 31730751 DOI: 10.1021/Acs.Chemrestox.9B00293  0.338
2019 Herron JM, Hines KM, Tomita H, Seguin RP, Cui JY, Xu L. Multi-omics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31199489 DOI: 10.1093/Toxsci/Kfz139  0.313
2018 Herron J, Hines KM, Xu L. Assessment of Altered Cholesterol Homeostasis by Xenobiotics Using Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry. Current Protocols in Toxicology. 78: e65. PMID 30320450 DOI: 10.1002/Cptx.65  0.31
2017 Aliwarga T, Raccor BS, Lemaitre RN, Sotoodehnia N, Gharib SA, Xu L, Totah RA. Enzymatic and Free Radical Formation of Cis- and Trans- Epoxyeicosatrienoic Acids In Vitro and In Vivo. Free Radical Biology & Medicine. PMID 28734877 DOI: 10.1016/J.Freeradbiomed.2017.07.015  0.343
2017 Lamberson CR, Muchalski H, McDuffee KB, Tallman KA, Xu L, Porter NA. Propagation Rate Constants for the Peroxidation of Sterols on the Biosynthetic Pathway to Cholesterol. Chemistry and Physics of Lipids. PMID 28174017 DOI: 10.1016/J.Chemphyslip.2017.01.006  0.349
2017 Hines KM, Herron J, Xu L. Assessment of Altered Lipid Homeostasis by HILIC-Ion Mobility-Mass Spectrometry-Based Lipidomics. Journal of Lipid Research. PMID 28167702 DOI: 10.1194/Jlr.D074724  0.319
2016 Sever N, Mann RK, Xu L, Snell WJ, Hernandez-Lara CI, Porter NA, Beachy PA. Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols. Proceedings of the National Academy of Sciences of the United States of America. PMID 27162362 DOI: 10.1073/Pnas.1604984113  0.306
2016 Herron J, Reese R, Tallman KA, Narayanaswamy R, Porter NA, Xu L. Identification of Environmental Quaternary Ammonium Compounds as Direct Inhibitors of Cholesterol Biosynthesis. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26919959 DOI: 10.1093/Toxsci/Kfw041  0.315
2015 Muchalski H, Xu L, Porter NA. Tunneling in tocopherol-mediated peroxidation of 7-dehydrocholesterol. Organic & Biomolecular Chemistry. 13: 1249-53. PMID 25435103 DOI: 10.1039/C4Ob02377C  0.33
2014 Xu L, Porter NA. Free radical oxidation of cholesterol and its precursors: Implications in cholesterol biosynthesis disorders. Free Radical Research. 1-15. PMID 25381800 DOI: 10.3109/10715762.2014.985219  0.421
2014 Goyal S, Xiao Y, Porter NA, Xu L, Guengerich FP. Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1. Journal of Lipid Research. 55: 1933-43. PMID 25017465 DOI: 10.1194/Jlr.M051508  0.334
2014 Xu L, Porter NA. Reactivities and products of free radical oxidation of cholestadienols. Journal of the American Chemical Society. 136: 5443-50. PMID 24625033 DOI: 10.1021/Ja5011674  0.349
2014 Lamberson CR, Xu L, Muchalski H, Montenegro-Burke JR, Shmanai VV, Bekish AV, McLean JA, Clarke CF, Shchepinov MS, Porter NA. Unusual kinetic isotope effects of deuterium reinforced polyunsaturated fatty acids in tocopherol-mediated free radical chain oxidations. Journal of the American Chemical Society. 136: 838-41. PMID 24380377 DOI: 10.1021/Ja410569G  0.378
2014 Liu W, Xu L, Lamberson C, Haas D, Korade Z, Porter NA. A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome. Journal of Lipid Research. 55: 329-37. PMID 24259532 DOI: 10.1194/Jlr.D043877  0.312
2014 Korade Z, Xu L, Harrison FE, Ahsen R, Hart SE, Folkes OM, Mirnics K, Porter NA. Antioxidant supplementation ameliorates molecular deficits in Smith-Lemli-Opitz syndrome. Biological Psychiatry. 75: 215-22. PMID 23896203 DOI: 10.1016/J.Biopsych.2013.06.013  0.331
2013 Xu L, Korade Z, Rosado DA, Mirnics K, Porter NA. Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells. Journal of Lipid Research. 54: 1135-43. PMID 23381570 DOI: 10.1194/Jlr.M035733  0.329
2013 Liu W, Xu L, Lamberson CR, Merkens LS, Steiner RD, Elias ER, Haas D, Porter NA. Assays of plasma dehydrocholesteryl esters and oxysterols from Smith-Lemli-Opitz syndrome patients. Journal of Lipid Research. 54: 244-53. PMID 23072947 DOI: 10.1194/Jlr.M031732  0.354
2013 Korade Z, Xu L, Mirnics K, Porter NA. Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome. Journal of Inherited Metabolic Disease. 36: 113-22. PMID 22718275 DOI: 10.1007/S10545-012-9504-Z  0.35
2013 Lamberson CR, Xu L, Muchalski H, Shchepinov MS, Porter Na. 340 – Unusual Kinetic Isotope Effects of Deuterium Reinforced Polyunsaturated Fatty Acids in Tocopherol-Mediated Free Radical Chain Oxidations Free Radical Biology and Medicine. 65. DOI: 10.1016/J.Freeradbiomed.2013.10.613  0.345
2012 Hill S, Lamberson CR, Xu L, To R, Tsui HS, Shmanai VV, Bekish AV, Awad AM, Marbois BN, Cantor CR, Porter NA, Clarke CF, Shchepinov MS. Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation. Free Radical Biology & Medicine. 53: 893-906. PMID 22705367 DOI: 10.1016/J.Freeradbiomed.2012.06.004  0.33
2012 Xu L, Sheflin LG, Porter NA, Fliesler SJ. 7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome. Biochimica Et Biophysica Acta. 1821: 877-83. PMID 22425966 DOI: 10.1016/J.Bbalip.2012.03.001  0.319
2012 Xu L, Mirnics K, Bowman AB, Liu W, Da J, Porter NA, Korade Z. DHCEO accumulation is a critical mediator of pathophysiology in a Smith-Lemli-Opitz syndrome model. Neurobiology of Disease. 45: 923-9. PMID 22182693 DOI: 10.1016/J.Nbd.2011.12.011  0.324
2012 Xu L, Korade Z, Mirnics K, Porter NA. Establishment of Oxysterol Biomarkers in a Mouse Model of Smith-Lemli-Opitz Syndrome and the Effect of Antioxidant Supplementation Free Radical Biology and Medicine. 53: S122. DOI: 10.1016/J.Freeradbiomed.2012.10.302  0.354
2011 Yin H, Xu L, Porter NA. Free radical lipid peroxidation: mechanisms and analysis. Chemical Reviews. 111: 5944-72. PMID 21861450 DOI: 10.1021/Cr200084Z  0.358
2011 Xu L, Liu W, Sheflin LG, Fliesler SJ, Porter NA. Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome. Journal of Lipid Research. 52: 1810-20. PMID 21817059 DOI: 10.1194/Jlr.M018366  0.306
2011 Shinkyo R, Xu L, Tallman KA, Cheng Q, Porter NA, Guengerich FP. Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate. The Journal of Biological Chemistry. 286: 33021-8. PMID 21813643 DOI: 10.1074/Jbc.M111.282434  0.319
2011 Xu L, Korade Z, Rosado DA, Liu W, Lamberson CR, Porter NA. An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome. Journal of Lipid Research. 52: 1222-33. PMID 21402677 DOI: 10.1194/Jlr.M014498  0.368
2010 Korade Z, Xu L, Shelton R, Porter NA. Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome. Journal of Lipid Research. 51: 3259-69. PMID 20702862 DOI: 10.1194/Jlr.M009365  0.333
2010 Vanover E, Huang Y, Xu L, Newcomb M, Zhang R. Photocatalytic aerobic oxidation by a bis-porphyrin-ruthenium(IV) mu-oxo dimer: observation of a putative porphyrin-ruthenium(V)-oxo intermediate. Organic Letters. 12: 2246-9. PMID 20394434 DOI: 10.1021/Ol1005938  0.521
2010 Xu L, Korade Z, Porter NA. Oxysterols from free radical chain oxidation of 7-dehydrocholesterol: product and mechanistic studies. Journal of the American Chemical Society. 132: 2222-32. PMID 20121089 DOI: 10.1021/Ja9080265  0.384
2010 Xu L, Korade Z, Liu W, Lamberson CR, Shelton R, Porter NA. Oxysterols Formed from the Most Oxidizable Lipid, 7-dehydrocholesterol, in vitro and in vivo: Implications for Smith-Lemli-Opitz Syndrome Free Radical Biology and Medicine. 49: S158. DOI: 10.1016/J.Freeradbiomed.2010.10.447  0.31
2009 Xu L, Davis TA, Porter NA. Rate constants for peroxidation of polyunsaturated fatty acids and sterols in solution and in liposomes. Journal of the American Chemical Society. 131: 13037-44. PMID 19705847 DOI: 10.1021/Ja9029076  0.355
2007 Xu L, Jin J, Lal M, Daublain P, Newcomb M. Compatible injection and detection systems for studying the kinetics of excess electron transfer. Organic Letters. 9: 1837-40. PMID 17373807 DOI: 10.1021/Ol070593J  0.661
2005 Xu L, Newcomb M. Acid-, base-, and lewis-acid-catalyzed heterolysis of methoxide from an alpha-hydroxy-beta-methoxy radical: models for reactions catalyzed by coenzyme B12-dependent diol dehydratase. The Journal of Organic Chemistry. 70: 9296-303. PMID 16268602 DOI: 10.1021/Jo051349D  0.547
2004 Miranda N, Xu L, Newcomb M. Lewis acid catalysis in heterolysis reactions of glycol ether radicals mimicking diol dehydratase-catalyzed reactions. Organic Letters. 6: 4511-4. PMID 15548063 DOI: 10.1021/Ol0481131  0.518
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