Kasper B. Hansen, PhD - Publications

2006-2013 Pharmacology Emory University, Atlanta, GA 
 2013- Biomedical and Pharmaceutical Sciences University of Montana, Missoula, MT 
NMDA receptors, ion channel structure & function

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kayser S, Hansen JC, Staudt M, Moroz A, Larsen Y, Temperini P, Yi F, Syrenne JT, Krogsgaard-Larsen N, Iliadis S, Nielsen B, Hansen KB, Pickering DS, Bunch L. Stereoselective Synthesis of New (2,3)-3-Carboxyphenyl)pyrrolidine-2-carboxylic Acid Analogues Utilizing a C(sp)-H Activation Strategy and Structure-Activity Relationship Studies at the Ionotropic Glutamate Receptors. Acs Chemical Neuroscience. PMID 32065744 DOI: 10.1021/Acschemneuro.0C00003  1
2020 Yi F, Rouzbeh N, Hansen KB, Xu Y, Fanger CM, Gordon E, Paschetto K, Menniti FS, Volkmann RA. PTC-174, a positive allosteric modulator of NMDA receptors containing GluN2C or GluN2D subunits. Neuropharmacology. 107971. PMID 31987864 DOI: 10.1016/J.Neuropharm.2020.107971  1
2019 Yi F, Bhattacharya S, Thompson CM, Traynelis SF, Hansen KB. Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors. The Journal of Physiology. PMID 31541561 DOI: 10.1113/Jp278168  1
2019 Poulie CBM, Alcaide A, Krell-Jørgensen M, Larsen Y, Astier E, Bjørn-Yoshimoto WE, Yi F, Syrenne JT, Storgaard M, Nielsen B, Frydenvang KA, Jensen AA, Hansen KB, Pickering DS, Bunch L. Design and Synthesis of 2,3- trans-Proline Analogues as Ligands for Ionotropic Glutamate Receptors and Excitatory Amino Acid Transporters. Acs Chemical Neuroscience. PMID 31124660 DOI: 10.1021/Acschemneuro.9B00205  1
2019 Sainas S, Temperini P, Farnsworth JC, Yi F, M Oslash Llerud S, Jensen A, Nielsen B, Passoni A, Kastrup JS, Hansen KB, Boschi D, Pickering DS, Clausen RP, Lolli ML. Use of the 4-Hydroxy-Triazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands. Journal of Medicinal Chemistry. PMID 30943028 DOI: 10.1021/Acs.Jmedchem.8B01986  1
2018 Yi F, Zachariassen LG, Dorsett KN, Hansen KB. Properties of triheteromeric NMDA receptors containing two distinct GluN1 isoforms. Molecular Pharmacology. PMID 29483146 DOI: 10.1124/Mol.117.111427  1
2017 Gynther M, Proietti Silvestri I, Hansen JC, Hansen KB, Malm T, Ishchenko Y, Larsen Y, Han L, Kayser S, Auriola S, Petsalo A, Nielsen B, Pickering DS, Bunch L. Augmentation of Anticancer Drug Efficacy in Murine Hepatocellular Carcinoma Cells by a Peripherally Acting Competitive N-Methyl-d-aspartate (NMDA) Receptor Antagonist. Journal of Medicinal Chemistry. 60: 9885-9904. PMID 29205034 DOI: 10.1021/Acs.Jmedchem.7B01624  1
2017 Yi F, Traynelis SF, Hansen KB. Selective Cell-Surface Expression of Triheteromeric NMDA Receptors. Methods in Molecular Biology (Clifton, N.J.). 1677: 145-162. PMID 28986871 DOI: 10.1007/978-1-4939-7321-7_7  1
2017 Hansen KB, Yi F, Perszyk RE, Menniti FS, Traynelis SF. NMDA Receptors in the Central Nervous System. Methods in Molecular Biology (Clifton, N.J.). 1677: 1-80. PMID 28986865 DOI: 10.1007/978-1-4939-7321-7_1  1
2017 Jessen M, Frederiksen K, Yi F, Clausen RP, Hansen KB, Brauner-Osborne H, Kilburn P, Damholt A. Identification of AICP as a GluN2C-selective NMDA receptor superagonist at the GluN1 glycine site. Molecular Pharmacology. PMID 28588066 DOI: 10.1124/Mol.117.108944  1
2017 Maolanon A, Risgaard R, Wang SY, Snoep Y, Papangelis A, Yi F, Holley D, Barslund AF, Svenstrup N, Hansen KB, Clausen RP. Subtype-specific agonists for NMDA receptor glycine binding sites. Acs Chemical Neuroscience. PMID 28514141 DOI: 10.1021/Acschemneuro.7B00117  1
2017 Sun W, Hansen KB, Jahr CE. Allosteric Interactions between NMDA Receptor Subunits Shape the Developmental Shift in Channel Properties. Neuron. 94: 58-64.e3. PMID 28384476 DOI: 10.1016/J.Neuron.2017.03.018  1
2016 Tamborini L, Chen Y, Foss CA, Pinto A, Horti AG, Traynelis SF, De Micheli C, Mease RC, Hansen KB, Conti P, Pomper MG. Development of Radiolabeled Ligands Targeting the Glutamate Binding Site of the N-Methyl-d-aspartate Receptor as Potential Imaging Agents for Brain. Journal of Medicinal Chemistry. 59: 11110-11119. PMID 28002957 DOI: 10.1021/Acs.Jmedchem.6B01344  1
2016 Yi F, Mou TC, Dorsett KN, Volkmann RA, Menniti FS, Sprang SR, Hansen KB. Structural Basis for Negative Allosteric Modulation of GluN2A-Containing NMDA Receptors. Neuron. PMID 27618671 DOI: 10.1016/J.Neuron.2016.08.014  1
2015 Kristensen AS, Hansen KB, Naur P, Olsen L, Kurtkaya NL, Dravid SM, Kvist T, Yi F, Pohlsgaard J, Clausen RP, Gajhede M, Kastrup JS, Traynelis SF. Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors. Molecular Pharmacology. PMID 26661043 DOI: 10.1124/Mol.115.100909  1
2015 Zimmerman SS, Khatri A, Garnier-Amblard EC, Mullasseril P, Kurtkaya NL, Gyoneva S, Hansen KB, Traynelis SF, Liotta DC. Correction to "Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators". Journal of Medicinal Chemistry. 58: 2862. PMID 25738634 DOI: 10.1021/Acs.Jmedchem.5B00199  1
2015 Poulsen MH, Andersen J, Christensen R, Hansen KB, Traynelis SF, Strømgaard K, Kristensen AS. Binding of ArgTX-636 in the NMDA receptor ion channel. Journal of Molecular Biology. 427: 176-89. PMID 24862283 DOI: 10.1016/J.Jmb.2014.05.017  1
2014 Hansen KB, Traynelis SF. Glutamate receptors: mechanistic twists and turns. Nature Chemical Biology. 10: 698-9. PMID 25271345 DOI: 10.1038/Nchembio.1614  1
2014 Khatri A, Burger PB, Swanger SA, Hansen KB, Zimmerman S, Karakas E, Liotta DC, Furukawa H, Snyder JP, Traynelis SF. Structural determinants and mechanism of action of a GluN2C-selective NMDA receptor positive allosteric modulator. Molecular Pharmacology. 86: 548-60. PMID 25205677 DOI: 10.1124/Mol.114.094516  1
2014 Hansen KB, Ogden KK, Yuan H, Traynelis SF. Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors. Neuron. 81: 1084-96. PMID 24607230 DOI: 10.1016/J.Neuron.2014.01.035  1
2014 Zimmerman SS, Khatri A, Garnier-Amblard EC, Mullasseril P, Kurtkaya NL, Gyoneva S, Hansen KB, Traynelis SF, Liotta DC. Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators. Journal of Medicinal Chemistry. 57: 2334-56. PMID 24512267 DOI: 10.1021/Jm401695D  1
2014 Yuan H, Hansen KB, Zhang J, Pierson TM, Markello TC, Fajardo KV, Holloman CM, Golas G, Adams DR, Boerkoel CF, Gahl WA, Traynelis SF. Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy. Nature Communications. 5: 3251. PMID 24504326 DOI: 10.1038/Ncomms4251  1
2013 Kvist T, Steffensen TB, Greenwood JR, Mehrzad Tabrizi F, Hansen KB, Gajhede M, Pickering DS, Traynelis SF, Kastrup JS, Bräuner-Osborne H. Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. The Journal of Biological Chemistry. 288: 33124-35. PMID 24072709 DOI: 10.1074/Jbc.M113.480210  1
2013 Kvist T, Greenwood JR, Hansen KB, Traynelis SF, Bräuner-Osborne H. Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors. Neuropharmacology. 75: 324-36. PMID 23973313 DOI: 10.1016/J.Neuropharm.2013.08.003  1
2013 Hansen KB, Tajima N, Risgaard R, Perszyk RE, Jørgensen L, Vance KM, Ogden KK, Clausen RP, Furukawa H, Traynelis SF. Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors. Molecular Pharmacology. 84: 114-27. PMID 23625947 DOI: 10.1124/Mol.113.085803  1
2013 Risgaard R, Nielsen SD, Hansen KB, Jensen CM, Nielsen B, Traynelis SF, Clausen RP. Development of 2'-substituted (2S,1'R,2'S)-2-(carboxycyclopropyl)glycine analogues as potent N-methyl-d-aspartic acid receptor agonists. Journal of Medicinal Chemistry. 56: 4071-81. PMID 23614571 DOI: 10.1021/Jm400346A  1
2013 Vance KM, Hansen KB, Traynelis SF. Modal gating of GluN1/GluN2D NMDA receptors. Neuropharmacology. 71: 184-90. PMID 23578394 DOI: 10.1016/J.Neuropharm.2013.03.018  1
2012 Vance KM, Hansen KB, Traynelis SF. GluN1 splice variant control of GluN1/GluN2D NMDA receptors. The Journal of Physiology. 590: 3857-75. PMID 22641781 DOI: 10.1113/Jphysiol.2012.234062  1
2012 Hansen KB, Ogden KK, Traynelis SF. Subunit-selective allosteric inhibition of glycine binding to NMDA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 6197-208. PMID 22553026 DOI: 10.1523/Jneurosci.5757-11.2012  1
2012 Hedegaard M, Hansen KB, Andersen KT, Bräuner-Osborne H, Traynelis SF. Molecular pharmacology of human NMDA receptors. Neurochemistry International. 61: 601-9. PMID 22197913 DOI: 10.1016/J.Neuint.2011.11.016  1
2012 Hansen KB, Wollmuth LP, Traynelis SF. Structure-function correlates of glutamate-gated ion channels Comprehensive Biophysics. 6: 4-30. DOI: 10.1016/B978-0-12-374920-8.00611-1  1
2011 Kvist T, Hansen KB, Bräuner-Osborne H. The use of Xenopus oocytes in drug screening. Expert Opinion On Drug Discovery. 6: 141-53. PMID 22647133 DOI: 10.1517/17460441.2011.546396  1
2011 Acker TM, Yuan H, Hansen KB, Vance KM, Ogden KK, Jensen HS, Burger PB, Mullasseril P, Snyder JP, Liotta DC, Traynelis SF. Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Molecular Pharmacology. 80: 782-95. PMID 21807990 DOI: 10.1124/Mol.111.073239  1
2011 Hansen KB, Traynelis SF. How glutamate receptor subunits mix and match: details uncovered. Neuron. 71: 198-200. PMID 21791278 DOI: 10.1016/J.Neuron.2011.07.008  1
2011 Hansen KB, Traynelis SF. Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 3650-61. PMID 21389220 DOI: 10.1523/Jneurosci.5565-10.2011  1
2010 Mullasseril P, Hansen KB, Vance KM, Ogden KK, Yuan H, Kurtkaya NL, Santangelo R, Orr AG, Le P, Vellano KM, Liotta DC, Traynelis SF. A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nature Communications. 1: 90. PMID 20981015 DOI: 10.1038/Ncomms1085  1
2010 Risgaard R, Hansen KB, Clausen RP. Partial agonists and subunit selectivity at NMDA receptors. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 13910-8. PMID 20945316 DOI: 10.1002/Chem.201001366  1
2010 Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R. Glutamate receptor ion channels: structure, regulation, and function. Pharmacological Reviews. 62: 405-96. PMID 20716669 DOI: 10.1124/Pr.109.002451  1
2010 Mosley CA, Acker TM, Hansen KB, Mullasseril P, Andersen KT, Le P, Vellano KM, Bräuner-Osborne H, Liotta DC, Traynelis SF. Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. Journal of Medicinal Chemistry. 53: 5476-90. PMID 20684595 DOI: 10.1021/Jm100027P  1
2010 Conti P, Pinto A, Tamborini L, Madsen U, Nielsen B, Bräuner-Osborne H, Hansen KB, Landucci E, Pellegrini-Giampietro DE, De Sarro G, Donato Di Paola E, De Micheli C. Novel 3-carboxy- and 3-phosphonopyrazoline amino acids as potent and selective NMDA receptor antagonists: design, synthesis, and pharmacological characterization. Chemmedchem. 5: 1465-75. PMID 20665761 DOI: 10.1002/Cmdc.201000184  1
2010 Hansen KB, Furukawa H, Traynelis SF. Control of assembly and function of glutamate receptors by the amino-terminal domain. Molecular Pharmacology. 78: 535-49. PMID 20660085 DOI: 10.1124/Mol.110.067157  1
2010 Lolli ML, Giordano C, Pickering DS, Rolando B, Hansen KB, Foti A, Contreras-Sanz A, Amir A, Fruttero R, Gasco A, Nielsen B, Johansen TN. 4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues. Journal of Medicinal Chemistry. 53: 4110-8. PMID 20408529 DOI: 10.1021/Jm1001452  1
2010 Hansen KB, Mullasseril P, Dawit S, Kurtkaya NL, Yuan H, Vance KM, Orr AG, Kvist T, Ogden KK, Le P, Vellano KM, Lewis I, Kurtkaya S, Du Y, Qui M, et al. Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists. The Journal of Pharmacology and Experimental Therapeutics. 333: 650-62. PMID 20197375 DOI: 10.1124/Jpet.110.166256  1
2010 Andersen J, Olsen L, Hansen KB, Taboureau O, Jørgensen FS, Jørgensen AM, Bang-Andersen B, Egebjerg J, Strømgaard K, Kristensen AS. Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter. The Journal of Biological Chemistry. 285: 2051-63. PMID 19892699 DOI: 10.1074/Jbc.M109.072587  1
2009 Yuan H, Hansen KB, Vance KM, Ogden KK, Traynelis SF. Control of NMDA receptor function by the NR2 subunit amino-terminal domain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12045-58. PMID 19793963 DOI: 10.1523/Jneurosci.1365-09.2009  1
2009 Zhong H, Hansen KB, Boyle NJ, Han K, Muske G, Huang X, Egebjerg J, Sánchez C. An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant. Neuroscience Letters. 462: 207-12. PMID 19616061 DOI: 10.1016/J.Neulet.2009.07.030  1
2009 Hansen KB, Bräuner-Osborne H. Xenopus oocyte electrophysiology in GPCR drug discovery. Methods in Molecular Biology (Clifton, N.J.). 552: 343-57. PMID 19513662 DOI: 10.1007/978-1-60327-317-6_25  1
2009 Hansen KB, Bräuner-Osborne H. FLIPR assays of intracellular calcium in GPCR drug discovery. Methods in Molecular Biology (Clifton, N.J.). 552: 269-78. PMID 19513656 DOI: 10.1007/978-1-60327-317-6_19  1
2009 Andersen J, Taboureau O, Hansen KB, Olsen L, Egebjerg J, Strømgaard K, Kristensen AS. Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants. The Journal of Biological Chemistry. 284: 10276-84. PMID 19213730 DOI: 10.1074/Jbc.M806907200  1
2009 Hansen KB, Naur P, Kurtkaya NL, Kristensen AS, Gajhede M, Kastrup JS, Traynelis SF. Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 907-17. PMID 19176800 DOI: 10.1523/Jneurosci.4081-08.2009  1
2009 Sivaprakasam M, Hansen KB, David O, Nielsen B, Traynelis SF, Clausen RP, Couty F, Bunch L. Stereocontrolled synthesis and pharmacological evaluation of azetidine-2,3-dicarboxylic acids at NMDA receptors. Chemmedchem. 4: 110-7. PMID 19009584 DOI: 10.1002/Cmdc.200800226  1
2008 Clausen RP, Christensen C, Hansen KB, Greenwood JR, Jørgensen L, Micale N, Madsen JC, Nielsen B, Egebjerg J, Bräuner-Osborne H, Traynelis SF, Kristensen JL. N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands. Journal of Medicinal Chemistry. 51: 4179-87. PMID 18578474 DOI: 10.1021/Jm800025E  1
2008 Hansen KB, Bräuner-Osborne H, Egebjerg J. Pharmacological characterization of ligands at recombinant NMDA receptor subtypes by electrophysiological recordings and intracellular calcium measurements. Combinatorial Chemistry & High Throughput Screening. 11: 304-15. PMID 18473740 DOI: 10.2174/138620708784246040  1
2008 Yuan H, Geballe MT, Hansen KB, Traynelis SF. Structure and function of the NMDA receptor Structural and Functional Organization of the Synapse. 289-316. DOI: 10.1007/978-0-387-77232-5_11  1
2007 Naur P, Hansen KB, Kristensen AS, Dravid SM, Pickering DS, Olsen L, Vestergaard B, Egebjerg J, Gajhede M, Traynelis SF, Kastrup JS. Ionotropic glutamate-like receptor delta2 binds D-serine and glycine. Proceedings of the National Academy of Sciences of the United States of America. 104: 14116-21. PMID 17715062 DOI: 10.1073/Pnas.0703718104  1
2007 Erreger K, Geballe MT, Kristensen A, Chen PE, Hansen KB, Lee CJ, Yuan H, Le P, Lyuboslavsky PN, Micale N, Jørgensen L, Clausen RP, Wyllie DJ, Snyder JP, Traynelis SF. Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors. Molecular Pharmacology. 72: 907-20. PMID 17622578 DOI: 10.1124/Mol.107.037333  1
2007 Hansen KB, Yuan H, Traynelis SF. Structural aspects of AMPA receptor activation, desensitization and deactivation. Current Opinion in Neurobiology. 17: 281-8. PMID 17419047 DOI: 10.1016/J.Conb.2007.03.014  1
2007 Jørgensen CG, Clausen RP, Hansen KB, Bräuner-Osborne H, Nielsen B, Metzler B, Metzler BB, Kehler J, Krogsgaard-Larsen P, Madsen U. Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid. Organic & Biomolecular Chemistry. 5: 463-71. PMID 17340770 DOI: 10.1039/B615162K  1
2007 Christiansen B, Hansen KB, Wellendorph P, Bräuner-Osborne H. Pharmacological characterization of mouse GPRC6A, an L-alpha-amino-acid receptor modulated by divalent cations. British Journal of Pharmacology. 150: 798-807. PMID 17245368 DOI: 10.1038/Sj.Bjp.0707121  1
2005 Conti P, De Amici M, Grazioso G, Roda G, Pinto A, Hansen KB, Nielsen B, Madsen U, Bräuner-Osborne H, Egebjerg J, Vestri V, Pellegrini-Giampietro DE, Sibille P, Acher FC, De Micheli C. Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids. Journal of Medicinal Chemistry. 48: 6315-25. PMID 16190758 DOI: 10.1021/Jm0504499  0.32
2005 Hansen KB, Clausen RP, Bjerrum EJ, Bechmann C, Greenwood JR, Christensen C, Kristensen JL, Egebjerg J, Bräuner-Osborne H. Tweaking agonist efficacy at N-methyl-D-aspartate receptors by site-directed mutagenesis. Molecular Pharmacology. 68: 1510-23. PMID 16131614 DOI: 10.1124/Mol.105.014795  1
2005 Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H. Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Molecular Pharmacology. 67: 589-97. PMID 15576628 DOI: 10.1124/Mol.104.007559  1
2004 Clausen RP, Hansen KB, Calí P, Nielsen B, Greenwood JR, Begtrup M, Egebjerg J, Bräuner-Osborne H. The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid. European Journal of Pharmacology. 499: 35-44. PMID 15363949 DOI: 10.1016/J.Ejphar.2004.07.049  1
2003 Brehm L, Greenwood JR, Hansen KB, Nielsen B, Egebjerg J, Stensbøl TB, Bräuner-Osborne H, Sløk FA, Kronborg TT, Krogsgaard-Larsen P. (S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology. Journal of Medicinal Chemistry. 46: 1350-8. PMID 12672235 DOI: 10.1021/Jm0204441  1
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