Shin-ichi Ohnuma, Ph.D. - Publications

Institute of Ophthalmology University College London, London, United Kingdom 

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Luehders K, Sasai N, Davaapil H, Kurosawa-Yoshida M, Hiura H, Brah T, Ohnuma S. The small leucine-rich repeat secreted protein Asporin induces eyes in Xenopus embryos through the IGF signalling pathway. Development (Cambridge, England). 142: 3351-61. PMID 26443635 DOI: 10.1242/dev.124438  1
2015 Tashima T, Nagatoishi S, Sagara H, Ohnuma S, Tsumoto K. Osteomodulin regulates diameter and alters shape of collagen fibrils. Biochemical and Biophysical Research Communications. 463: 292-6. PMID 26003732 DOI: 10.1016/j.bbrc.2015.05.053  1
2015 Dellett M, Sasai N, Nishide K, Becker S, Papadaki V, Limb GA, Moore AT, Kondo T, Ohnuma S. Genetic background and light-dependent progression of photoreceptor cell degeneration in Prominin-1 knockout mice. Investigative Ophthalmology & Visual Science. 56: 164-76. PMID 25414197 DOI: 10.1167/iovs.14-15479  1
2014 Gichuhi S, Ohnuma S, Sagoo MS, Burton MJ. Pathophysiology of ocular surface squamous neoplasia. Experimental Eye Research. 129: 172-82. PMID 25447808 DOI: 10.1016/j.exer.2014.10.015  1
2014 Tsuchiya Y, Pham U, Hu W, Ohnuma S, Gout I. Changes in acetyl CoA levels during the early embryonic development of Xenopus laevis. Plos One. 9: e97693. PMID 24831956 DOI: 10.1371/journal.pone.0097693  1
2013 Hu W, Haamedi N, Lee J, Kinoshita T, Ohnuma S. The structure and development of Xenopus laevis cornea. Experimental Eye Research. 116: 109-28. PMID 23896054 DOI: 10.1016/j.exer.2013.07.021  1
2013 Wang F, Hu W, Xian J, Ohnuma S, Brenton JD. The Xenopus Tgfbi is required for embryogenesis through regulation of canonical Wnt signalling. Developmental Biology. 379: 16-27. PMID 23246513 DOI: 10.1016/j.ydbio.2012.11.010  1
2012 Cho HS, Shimazu T, Toyokawa G, Daigo Y, Maehara Y, Hayami S, Ito A, Masuda K, Ikawa N, Field HI, Tsuchiya E, Ohnuma S, Ponder BA, Yoshida M, Nakamura Y, et al. Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B. Nature Communications. 3: 1072. PMID 22990868 DOI: 10.1038/ncomms2074  1
2012 Bilitou A, De Marco N, Bello AM, Garzia L, Carotenuto P, Kim M, Campanella C, Ohnuma S, Zollo M. Spatial and temporal expressions of prune reveal a role in Müller gliogenesis during Xenopus retinal development. Gene. 509: 93-103. PMID 22967741 DOI: 10.1016/j.gene.2012.08.001  1
2012 Takawa M, Cho HS, Hayami S, Toyokawa G, Kogure M, Yamane Y, Iwai Y, Maejima K, Ueda K, Masuda A, Dohmae N, Field HI, Tsunoda T, Kobayashi T, Akasu T, ... ... Ohnuma S, et al. Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression. Cancer Research. 72: 3217-27. PMID 22556262 DOI: 10.1158/0008-5472.CAN-11-3701  1
2012 Dellett M, Hu W, Papadaki V, Ohnuma S. Small leucine rich proteoglycan family regulates multiple signalling pathways in neural development and maintenance. Development, Growth & Differentiation. 54: 327-40. PMID 22524604 DOI: 10.1111/j.1440-169X.2012.01339.x  1
2011 Ohta K, Ito A, Kuriyama S, Lupo G, Kosaka M, Ohnuma S, Nakagawa S, Tanaka H. Tsukushi functions as a Wnt signaling inhibitor by competing with Wnt2b for binding to transmembrane protein Frizzled4. Proceedings of the National Academy of Sciences of the United States of America. 108: 14962-7. PMID 21856951 DOI: 10.1073/pnas.1100513108  1
2010 Bilitou A, Ohnuma S. The role of cell cycle in retinal development: cyclin-dependent kinase inhibitors co-ordinate cell-cycle inhibition, cell-fate determination and differentiation in the developing retina. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 727-36. PMID 20108332 DOI: 10.1002/dvdy.22223  1
2009 Bilitou A, Watson J, Gartner A, Ohnuma S. The NM23 family in development. Molecular and Cellular Biochemistry. 329: 17-33. PMID 19421718 DOI: 10.1007/s11010-009-0121-6  1
2009 Mochizuki T, Bilitou A, Waters CT, Hussain K, Zollo M, Ohnuma S. Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1. Neural Development. 4: 1. PMID 19123928 DOI: 10.1186/1749-8104-4-1  1
2007 Morris SA, Almeida AD, Tanaka H, Ohta K, Ohnuma S. Tsukushi modulates Xnr2, FGF and BMP signaling: regulation of Xenopus germ layer formation. Plos One. 2: e1004. PMID 17925852 DOI: 10.1371/journal.pone.0001004  1
2006 Ohta K, Kuriyama S, Okafuji T, Gejima R, Ohnuma S, Tanaka H. Tsukushi cooperates with VG1 to induce primitive streak and Hensen's node formation in the chick embryo. Development (Cambridge, England). 133: 3777-86. PMID 16943268 DOI: 10.1242/dev.02579  1
2006 Vernon AE, Movassagh M, Horan I, Wise H, Ohnuma S, Philpott A. Notch targets the Cdk inhibitor Xic1 to regulate differentiation but not the cell cycle in neurons. Embo Reports. 7: 643-8. PMID 16648822 DOI: 10.1038/sj.embor.7400691  1
2006 Harrington AE, Morris-Triggs SA, Ruotolo BT, Robinson CV, Ohnuma S, Hyvönen M. Structural basis for the inhibition of activin signalling by follistatin. The Embo Journal. 25: 1035-45. PMID 16482217 DOI: 10.1038/sj.emboj.7601000  1
2006 Kuriyama S, Lupo G, Ohta K, Ohnuma S, Harris WA, Tanaka H. Tsukushi controls ectodermal patterning and neural crest specification in Xenopus by direct regulation of BMP4 and X-delta-1 activity. Development (Cambridge, England). 133: 75-88. PMID 16319115 DOI: 10.1242/dev.02178  1
2004 Daniels M, Dhokia V, Richard-Parpaillon L, Ohnuma S. Identification of Xenopus cyclin-dependent kinase inhibitors, p16Xic2 and p17Xic3. Gene. 342: 41-7. PMID 15527964 DOI: 10.1016/j.gene.2004.07.038  1
2004 Daniels M, Shimizu K, Zorn AM, Ohnuma S. Negative regulation of Smad2 by PIASy is required for proper Xenopus mesoderm formation. Development (Cambridge, England). 131: 5613-26. PMID 15496439 DOI: 10.1242/dev.01449  1
2004 Ohta K, Lupo G, Kuriyama S, Keynes R, Holt CE, Harris WA, Tanaka H, Ohnuma S. Tsukushi functions as an organizer inducer by inhibition of BMP activity in cooperation with chordin. Developmental Cell. 7: 347-58. PMID 15363410 DOI: 10.1016/j.devcel.2004.08.014  1
2003 Ohnuma S, Harris WA. Neurogenesis and the cell cycle. Neuron. 40: 199-208. PMID 14556704 DOI: 10.1016/S0896-6273(03)00632-9  1
2003 Cremisi F, Philpott A, Ohnuma S. Cell cycle and cell fate interactions in neural development. Current Opinion in Neurobiology. 13: 26-33. PMID 12593979 DOI: 10.1016/S0959-4388(03)00005-9  1
2002 Ohnuma S, Mann F, Boy S, Perron M, Harris WA. Lipofection strategy for the study of Xenopus retinal development. Methods (San Diego, Calif.). 28: 411-9. PMID 12507459 DOI: 10.1016/S1046-2023(02)00260-8  1
2002 Ohnuma S, Hopper S, Wang KC, Philpott A, Harris WA. Co-ordinating retinal histogenesis: early cell cycle exit enhances early cell fate determination in the Xenopus retina. Development (Cambridge, England). 129: 2435-46. PMID 11973275  1
2001 Ohnuma S, Philpott A, Harris WA. Cell cycle and cell fate in the nervous system. Current Opinion in Neurobiology. 11: 66-73. PMID 11179874 DOI: 10.1016/S0959-4388(00)00175-6  1
2000 Wang KC, Ohnuma S. Isoprenyl diphosphate synthases. Biochimica Et Biophysica Acta. 1529: 33-48. PMID 11111076 DOI: 10.1016/S1388-1981(00)00136-0  1
2000 Hirooka K, Ohnuma S, Koike-Takeshita A, Koyama T, Nishino T. Mechanism of product chain length determination for heptaprenyl diphosphate synthase from Bacillus stearothermophilus. European Journal of Biochemistry / Febs. 267: 4520-8. PMID 10880976 DOI: 10.1046/j.1432-1327.2000.01502.x  1
1999 Ohnuma S, Philpott A, Wang K, Holt CE, Harris WA. p27Xic1, a Cdk inhibitor, promotes the determination of glial cells in Xenopus retina. Cell. 99: 499-510. PMID 10589678  1
1999 Wang K, Ohnuma S. Chain-length determination mechanism of isoprenyl diphosphate synthases and implications for molecular evolution. Trends in Biochemical Sciences. 24: 445-51. PMID 10542413 DOI: 10.1016/S0968-0004(99)01464-4  1
1999 Ruchhoeft ML, Ohnuma S, McNeill L, Holt CE, Harris WA. The neuronal architecture of Xenopus retinal ganglion cells is sculpted by rho-family GTPases in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 8454-63. PMID 10493746  1
1999 Narita K, Ohnuma S, Nishino T. Protein design of geranyl diphosphate synthase. Structural features that define the product specificities of prenyltransferases. Journal of Biochemistry. 126: 566-71. PMID 10467173  1
1998 Ohnuma S, Hirooka K, Tsuruoka N, Yano M, Ohto C, Nakane H, Nishino T. A pathway where polyprenyl diphosphate elongates in prenyltransferase. Insight into a common mechanism of chain length determination of prenyltransferases. The Journal of Biological Chemistry. 273: 26705-13. PMID 9756913 DOI: 10.1074/jbc.273.41.26705  1
1998 Ohto C, Nakane H, Hemmi H, Ohnuma S, Obata S, Nishino T. Overexpression of an archaeal geranylgeranyl diphosphate synthase in Escherichia coli cells. Bioscience, Biotechnology, and Biochemistry. 62: 1243-6. PMID 9692210 DOI: 10.1271/bbb.62.1243  1
1998 Hemmi H, Ohnuma S, Nagaoka K, Nishino T. Identification of genes affecting lycopene formation in Escherichia coli transformed with carotenoid biosynthetic genes: candidates for early genes in isoprenoid biosynthesis. Journal of Biochemistry. 123: 1088-96. PMID 9603997  1
1998 Ohnuma S, Hemmi H, Koyama T, Ogura K, Nishino T. Recognition of allylic substrates in Sulfolobus acidocaldarius geranylgeranyl diphosphate synthase: analysis using mutated enzymes and artificial allylic substrates. Journal of Biochemistry. 123: 1036-40. PMID 9603990  1
1997 Ohnuma S, Hemmi H, Ohto C, Nakane H, Nishino T. Effects of random mutagenesis in a putative substrate-binding domain of geranylgeranyl diphosphate synthase upon intermediate formation and substrate specificity. Journal of Biochemistry. 121: 696-704. PMID 9163520  1
1997 Ohnuma Si, Hirooka K, Ohto C, Nishino T. Conversion from archaeal geranylgeranyl diphosphate synthase to farnesyl diphosphate synthase. Two amino acids before the first aspartate-rich motif solely determine eukaryotic farnesyl diphosphate synthase activity. The Journal of Biological Chemistry. 272: 5192-8. PMID 9030588 DOI: 10.1074/jbc.272.8.5192  1
1996 Fujisaki S, Ohnuma S, Horiuchi T, Takahashi I, Tsukui S, Nishimura Y, Nishino T, Kitabatake M, Inokuchi H. Cloning of a gene from Escherichia coli that confers resistance to fosmidomycin as a consequence of amplification. Gene. 175: 83-7. PMID 8917080 DOI: 10.1016/0378-1119(96)00128-X  1
1996 Ohnuma SI, Watanabe M, Nishino T. Identification and characterization of geranylgeraniol kinase and geranylgeranyl phosphate kinase from the archaebacterium Sulfolobus acidocaldarius Journal of Biochemistry. 119: 541-547. PMID 8830051  1
1996 Ohnuma S, Hirooka K, Hemmi H, Ishida C, Ohto C, Nishino T. Conversion of product specificity of archaebacterial geranylgeranyl-diphosphate synthase. Identification of essential amino acid residues for chain length determination of prenyltransferase reaction. The Journal of Biological Chemistry. 271: 18831-7. PMID 8702542 DOI: 10.1074/jbc.271.31.18831  1
1996 Ohnuma SI, Nakazawa T, Hemmi H, Hallberg AM, Koyama T, Ogura K, Nishino T. Conversion from farnesyl diphosphate synthase to geranylgeranyl diphosphate synthase by random chemical mutagenesis Journal of Biological Chemistry. 271: 10087-10095. PMID 8626566 DOI: 10.1074/jbc.271.17.10087  1
1994 Ohnuma SI, Suzuki M, Nishino T. Archaebacterial ether-linked lipid biosynthetic gene: Expression cloning, sequencing, and characterization of geranylgeranyl-diphosphate synthase Journal of Biological Chemistry. 269: 14792-14797. PMID 8182085  1
1993 Ohnuma SI, Koyama T, Ogura K. Alteration of the product specificities of prenyltransferases by metal ions Biochemical and Biophysical Research Communications. 192: 407-412. PMID 8484753 DOI: 10.1006/bbrc.1993.1430  1
1993 Ohnuma Si, Koyama T, Ogura K. Solanesyl diphosphate synthase reaction with artificial substrates. Formation of R and S-enantiomers of 4- and 8- methyl derivatives of geranylgeranyl diphosphate Bioorganic and Medicinal Chemistry Letters. 3: 2733-2738. DOI: 10.1016/S0960-894X(01)80754-X  1
1991 Ohnuma SI, Koyama T, Ogura K. Purification of solanesyl-diphosphate synthase from Micrococcus luteus: A new class of prenyltransferase Journal of Biological Chemistry. 266: 23706-23713. PMID 1748647  1
1991 Ohnuma Si, Koyama T, Ogura K. Enzymatic synthesis of glycinoprenols Tetrahedron Letters. 32: 241-242. DOI: 10.1016/0040-4039(91)80865-4  1
1990 Koyama T, Inoue H, Ohnuma Si, Ogura K. Prenyltransferase reaction involving enantiomeric discrimination. Enzymatic synthesis of (S)-10, 11-epoxyfarnesol from racemic 6, 7-epoxygeranyl diphosphate and isopentenyl dipnosphate Tetrahedron Letters. 31: 4189-4190. DOI: 10.1016/S0040-4039(00)97578-6  1
1989 Ohnuma S, Koyama T, Ogura K. Kinetic studies on the prenyl chain elongation by undecaprenyl diphosphate synthase with artificial substrate homologues Febs Letters. 257: 71-74. PMID 2509247 DOI: 10.1016/0014-5793(89)81789-2  1
1989 Ohnuma Si, Ito M, Koyama T, Ogura K. Undecaprenyl diphosphate synthase reaction with artificial substrate homologues - novel behavior in the termination of prenyl chain elongation Tetrahedron. 45: 6145-6160. DOI: 10.1016/S0040-4020(01)85127-9  1
1988 Koyama T, Ito M, Ohnuma Si, Ogura K. Novel behavior of undecaprenyl diphosphate synthase toward an artificial substrate. Formation of the S-4-methyl derivative ofz,e,e,-geranylgeranyl diphosphate Tetrahedron Letters. 29: 3807-3810. DOI: 10.1016/S0040-4039(00)82120-6  1
1986 Kato T, Yamaguchi Y, Ohnuma SI, Uyehara T, Namai T, Kodama M, Shiobara Y. Structural elucidation of 11-hydroxy-12,13-epoxyoctadeca-(9Z,15Z)-dienoic acids from rice plants suffering from rice blast disease Journal of the Chemical Society, Chemical Communications. 743-744. DOI: 10.1039/C3986000743b  1
Show low-probability matches.