Donald C. Lo - Publications

Duke University, Durham, NC 

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Quinti L, Casale M, Moniot S, Pais TF, Van Kanegan MJ, Kaltenbach LS, Pallos J, Lim RG, Naidu SD, Runne H, Meisel L, Rauf NA, Leyfer D, Maxwell MM, Saiah E, ... ... Lo DC, et al. SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models. Cell Chemical Biology. PMID 27427231 DOI: 10.1016/j.chembiol.2016.05.015  1
2016 Van Kanegan MJ, Dunn DE, Kaltenbach LS, Shah B, He DN, McCoy DD, Yang P, Peng J, Shen L, Du L, Cichewicz RH, Newman RA, Lo DC. Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke. Scientific Reports. 6: 25626. PMID 27172999 DOI: 10.1038/Srep25626  1
2015 Kaplan A, Gaschler MM, Dunn DE, Colligan R, Brown LM, Palmer AG, Lo DC, Stockwell BR. Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective. Proceedings of the National Academy of Sciences of the United States of America. 112: E2245-52. PMID 25848045 DOI: 10.1073/Pnas.1500439112  1
2015 Christianson MG, Lo DC. Differential roles of Aβ processing in hypoxia-induced axonal damage. Neurobiology of Disease. 77: 94-105. PMID 25771168 DOI: 10.1016/J.Nbd.2015.02.027  1
2014 Yu A, Shibata Y, Shah B, Calamini B, Lo DC, Morimoto RI. Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition. Proceedings of the National Academy of Sciences of the United States of America. 111: E1481-90. PMID 24706768 DOI: 10.1073/Pnas.1321811111  1
2014 Skouta R, Dixon SJ, Wang J, Dunn DE, Orman M, Shimada K, Rosenberg PA, Lo DC, Weinberg JM, Linkermann A, Stockwell BR. Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. Journal of the American Chemical Society. 136: 4551-6. PMID 24592866 DOI: 10.1021/Ja411006A  1
2014 Van Kanegan MJ, He DN, Dunn DE, Yang P, Newman RA, West AE, Lo DC. BDNF mediates neuroprotection against oxygen-glucose deprivation by the cardiac glycoside oleandrin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 963-8. PMID 24431454 DOI: 10.1523/JNEUROSCI.2700-13.2014  1
2013 Keum S, Lee HK, Chu PL, Kan MJ, Huang MN, Gallione CJ, Gunn MD, Lo DC, Marchuk DA. Natural genetic variation of integrin alpha L (Itgal) modulates ischemic brain injury in stroke. Plos Genetics. 9: e1003807. PMID 24130503 DOI: 10.1371/Journal.Pgen.1003807  1
2013 Marco S, Giralt A, Petrovic MM, Pouladi MA, Martínez-Turrillas R, Martínez-Hernández J, Kaltenbach LS, Torres-Peraza J, Graham RK, Watanabe M, Luján R, Nakanishi N, Lipton SA, Lo DC, Hayden MR, et al. Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models. Nature Medicine. 19: 1030-8. PMID 23852340 DOI: 10.1038/Nm.3246  1
2013 Calamini B, Lo DC, Kaltenbach LS. Experimental models for identifying modifiers of polyglutamine-induced aggregation and neurodegeneration. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 10: 400-15. PMID 23700210 DOI: 10.1007/s13311-013-0195-4  1
2012 Tahtouh T, Elkins JM, Filippakopoulos P, Soundararajan M, Burgy G, Durieu E, Cochet C, Schmid RS, Lo DC, Delhommel F, Oberholzer AE, Pearl LH, Carreaux F, Bazureau JP, Knapp S, et al. Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B. Journal of Medicinal Chemistry. 55: 9312-30. PMID 22998443 DOI: 10.1021/jm301034u  1
2012 Appl T, Kaltenbach L, Lo DC, Terstappen GC. Targeting mutant huntingtin for the development of disease-modifying therapy. Drug Discovery Today. 17: 1217-23. PMID 22772050 DOI: 10.1016/j.drudis.2012.06.017  1
2012 Baldo B, Paganetti P, Grueninger S, Marcellin D, Kaltenbach LS, Lo DC, Semmelroth M, Zivanovic A, Abramowski D, Smith D, Lotz GP, Bates GP, Weiss A. TR-FRET-based duplex immunoassay reveals an inverse correlation of soluble and aggregated mutant huntingtin in huntington's disease. Chemistry & Biology. 19: 264-75. PMID 22365609 DOI: 10.1016/j.chembiol.2011.12.020  1
2012 Kraft AD, Kaltenbach LS, Lo DC, Harry GJ. Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons. Neurobiology of Aging. 33: 621.e17-33. PMID 21482444 DOI: 10.1016/J.Neurobiolaging.2011.02.015  1
2011 Christianson MG, Lo DC. Development of a low-pressure microtargeting biolistic device for transfection of retinal explants. Molecular Vision. 17: 2947-55. PMID 22128241  1
2011 Dunn DE, He DN, Yang P, Johansen M, Newman RA, Lo DC. In vitro and in vivo neuroprotective activity of the cardiac glycoside oleandrin from Nerium oleander in brain slice-based stroke models. Journal of Neurochemistry. 119: 805-14. PMID 21950737 DOI: 10.1111/j.1471-4159.2011.07439.x  1
2011 Gabriel T, García-Pérez E, Mahfooz K, Goñi J, Martínez-Turrillas R, Pérez-Otaño I, Lo DC, Wesseling JF. A new kinetic framework for synaptic vesicle trafficking tested in synapsin knock-outs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 11563-77. PMID 21832187 DOI: 10.1523/Jneurosci.1447-11.2011  1
2011 Reinhart PH, Kaltenbach LS, Essrich C, Dunn DE, Eudailey JA, DeMarco CT, Turmel GJ, Whaley JC, Wood A, Cho S, Lo DC. Identification of anti-inflammatory targets for Huntington's disease using a brain slice-based screening assay. Neurobiology of Disease. 43: 248-56. PMID 21458569 DOI: 10.1016/j.nbd.2011.03.017  1
2011 Southwell AL, Bugg CW, Kaltenbach LS, Dunn D, Butland S, Weiss A, Paganetti P, Lo DC, Patterson PH. Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1. Plos One. 6: e16676. PMID 21304966 DOI: 10.1371/Journal.Pone.0016676  1
2010 Leyva MJ, Degiacomo F, Kaltenbach LS, Holcomb J, Zhang N, Gafni J, Park H, Lo DC, Salvesen GS, Ellerby LM, Ellman JA. Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models. Chemistry & Biology. 17: 1189-200. PMID 21095569 DOI: 10.1016/J.Chembiol.2010.08.014  1
2010 Hoffstrom BG, Kaplan A, Letso R, Schmid RS, Turmel GJ, Lo DC, Stockwell BR. Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins. Nature Chemical Biology. 6: 900-6. PMID 21079601 DOI: 10.1038/Nchembio.467  1
2010 Kaltenbach LS, Bolton MM, Shah B, Kanju PM, Lewis GM, Turmel GJ, Whaley JC, Trask OJ, Lo DC. Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions. Journal of Biomolecular Screening. 15: 806-19. PMID 20581077 DOI: 10.1177/1087057110373392  1
2010 Braithwaite SP, Schmid RS, He DN, Sung ML, Cho S, Resnick L, Monaghan MM, Hirst WD, Essrich C, Reinhart PH, Lo DC. Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease. Neurobiology of Disease. 39: 311-7. PMID 20451607 DOI: 10.1016/j.nbd.2010.04.015  1
2010 Crittenden JR, Dunn DE, Merali FI, Woodman B, Yim M, Borkowska AE, Frosch MP, Bates GP, Housman DE, Lo DC, Graybiel AM. CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease. Human Molecular Genetics. 19: 1756-65. PMID 20147317 DOI: 10.1093/Hmg/Ddq055  1
2009 Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, ... ... Lo DC, et al. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. The Journal of Cell Biology. 187: 1083-99. PMID 20026656 DOI: 10.1083/Jcb.200909067  1
2009 Qiao L, Choi S, Case A, Gainer TG, Seyb K, Glicksman MA, Lo DC, Stein RL, Cuny GD. Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 6122-6. PMID 19783434 DOI: 10.1016/J.Bmcl.2009.09.010  1
2009 Roberts AC, Díez-García J, Rodriguiz RM, López IP, Luján R, Martínez-Turrillas R, Picó E, Henson MA, Bernardo DR, Jarrett TM, Clendeninn DJ, López-Mascaraque L, Feng G, Lo DC, Wesseling JF, et al. Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation. Neuron. 63: 342-56. PMID 19679074 DOI: 10.1016/J.Neuron.2009.06.016  1
2008 Southwell AL, Khoshnan A, Dunn DE, Bugg CW, Lo DC, Patterson PH. Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 9013-20. PMID 18768695 DOI: 10.1523/Jneurosci.2747-08.2008  1
2008 Garcia-Perez E, Lo DC, Wesseling JF. Kinetic isolation of a slowly recovering component of short-term depression during exhaustive use at excitatory hippocampal synapses. Journal of Neurophysiology. 100: 781-95. PMID 18579659 DOI: 10.1152/Jn.90429.2008  1
2008 Varma H, Lo DC, Stockwell BR. High throughput screening for neurodegeneration and complex disease phenotypes. Combinatorial Chemistry & High Throughput Screening. 11: 238-48. PMID 18336216 DOI: 10.2174/138620708783877753  1
2007 Varma H, Voisine C, DeMarco CT, Cattaneo E, Lo DC, Hart AC, Stockwell BR. Selective inhibitors of death in mutant huntingtin cells. Nature Chemical Biology. 3: 99-100. PMID 17195849 DOI: 10.1038/Nchembio852  1
2007 Trask OJ, Demarco CT, Dunn D, Gainer TG, Eudailey J, Kaltenbach L, Lo DC. Live Brain Slice Imaging for Ultra High Content Screening: Automated Fluorescent Microscopy to Study Neurodegenerative Diseases High Content Screening: Science, Techniques and Applications. 189-204. DOI: 10.1002/9780470229866.ch8  1
2006 Wang JK, Portbury S, Thomas MB, Barney S, Ricca DJ, Morris DL, Warner DS, Lo DC. Cardiac glycosides provide neuroprotection against ischemic stroke: discovery by a brain slice-based compound screening platform. Proceedings of the National Academy of Sciences of the United States of America. 103: 10461-6. PMID 16793926 DOI: 10.1073/pnas.0600930103  1
2006 Pérez-Otaño I, Luján R, Tavalin SJ, Plomann M, Modregger J, Liu XB, Jones EG, Heinemann SF, Lo DC, Ehlers MD. Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1. Nature Neuroscience. 9: 611-21. PMID 16617342 DOI: 10.1038/nn1680  1
2002 Danzer SC, Crooks KR, Lo DC, McNamara JO. Increased expression of brain-derived neurotrophic factor induces formation of basal dendrites and axonal branching in dentate granule cells in hippocampal explant cultures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9754-63. PMID 12427830 DOI: 10.1523/Jneurosci.22-22-09754.2002  1
2002 Wesseling JF, Lo DC. Limit on the role of activity in controlling the release-ready supply of synaptic vesicles. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9708-20. PMID 12427826 DOI: 10.1523/Jneurosci.22-22-09708.2002  1
2002 Lo DC. CNS discovery: Time to use our brains Current Drug Discovery. 27-30.  1
2001 Lo DC. Neuronal transfection using particle-mediated gene transfer. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 3.15. PMID 18428464 DOI: 10.1002/0471142301.ns0315s05  1
2001 Lo DC. Challenges for neuroscience in a post-genome world. Nature Neuroscience. 4: 1153-4. PMID 11687820 DOI: 10.1038/nn1101-1153  1
2000 Bolton MM, Lo DC, Sherwood NT. Long-term regulation of excitatory and inhibitory synaptic transmission in hippocampal cultures by brain-derived neurotrophic factor. Progress in Brain Research. 128: 203-18. PMID 11105680 DOI: 10.1016/S0079-6123(00)28018-7  1
2000 Lesser SS, Lo DC. CNTF II, I presume? Nature Neuroscience. 3: 851-2. PMID 10966608 DOI: 10.1038/78738  1
2000 Bolton MM, Pittman AJ, Lo DC. Brain-derived neurotrophic factor differentially regulates excitatory and inhibitory synaptic transmission in hippocampal cultures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 3221-32. PMID 10777787 DOI: 10.1523/Jneurosci.20-09-03221.2000  1
2000 Yacoubian TA, Lo DC. Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth. Nature Neuroscience. 3: 342-9. PMID 10725923 DOI: 10.1038/73911  1
1999 Lesser SS, Holmes TM, Pittman AJ, Lo DC. Induction of electrical excitability by NGF requires autocrine action of a CNTF-like factor. Molecular and Cellular Neurosciences. 14: 169-79. PMID 10576888 DOI: 10.1006/mcne.1999.0778  1
1999 Sherwood NT, Lo DC. Long-term enhancement of central synaptic transmission by chronic brain-derived neurotrophic factor treatment. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 7025-36. PMID 10436057 DOI: 10.1523/Jneurosci.19-16-07025.1999  1
1999 Kryl D, Yacoubian T, Haapasalo A, Castren E, Lo D, Barker PA. Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 5823-33. PMID 10407023 DOI: 10.1523/Jneurosci.19-14-05823.1999  1
1999 McAllister AK, Katz LC, Lo DC. Neurotrophins and synaptic plasticity. Annual Review of Neuroscience. 22: 295-318. PMID 10202541 DOI: 10.1146/annurev.neuro.22.1.295  1
1999 McAllister AK, Lo DC, Katz LC. The role of neurotrophins and activity in regulating cortical dendritic growth Developmental Neuropsychology. 16: 335-337. DOI: 10.1207/S15326942Dn1603_9  1
1998 Lo DC. Instructive roles of neurotrophins in synaptic plasticity. Progress in Brain Research. 117: 65-70. PMID 9932401 DOI: 10.1016/S0079-6123(08)64008-X  1
1997 Lesser SS, Sherwood NT, Lo DC. Neurotrophins differentially regulate voltage-gated ion channels. Molecular and Cellular Neurosciences. 10: 173-83. PMID 9532579 DOI: 10.1006/mcne.1997.0656  1
1997 Riddle DR, Katz LC, Lo DC. Focal delivery of neurotrophins into the central nervous system using fluorescent latex microspheres. Biotechniques. 23: 928-34, 936-7. PMID 9383561 DOI: 10.2144/97235Rr02  1
1997 McAllister AK, Katz LC, Lo DC. Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth. Neuron. 18: 767-78. PMID 9182801 DOI: 10.1016/S0896-6273(00)80316-5  1
1997 Sherwood NT, Lesser SS, Lo DC. Neurotrophin regulation of ionic currents and cell size depends on cell context. Proceedings of the National Academy of Sciences of the United States of America. 94: 5917-22. PMID 9159175 DOI: 10.1073/pnas.94.11.5917  1
1997 Xu Y, Nguyen Q, Lo DC, Czaja MJ. c-myc-Dependent hepatoma cell apoptosis results from oxidative stress and not a deficiency of growth factors. Journal of Cellular Physiology. 170: 192-9. PMID 9009148 DOI: 10.1002/(SICI)1097-4652(199702)170:2<192::AID-JCP11>3.0.CO;2-K  0.36
1996 Riddle DR, McAllister AK, Lo DC, Katz LC. Neurotrophins in cortical development. Cold Spring Harbor Symposia On Quantitative Biology. 61: 85-93. PMID 9246438 DOI: 10.1101/Sqb.1996.061.01.012  1
1996 McAllister AK, Katz LC, Lo DC. Neurotrophin regulation of cortical dendritic growth requires activity. Neuron. 17: 1057-64. PMID 8982155 DOI: 10.1016/S0896-6273(00)80239-1  1
1995 Lo DC. Neurotrophic factors and synaptic plasticity. Neuron. 15: 979-81. PMID 7576664 DOI: 10.1016/0896-6273(95)90085-3  1
1995 McAllister AK, Lo DC, Katz LC. Neurotrophins regulate dendritic growth in developing visual cortex. Neuron. 15: 791-803. PMID 7576629 DOI: 10.1016/0896-6273(95)90171-X  1
1995 Lesser SS, Lo DC. Regulation of voltage-gated ion channels by NGF and ciliary neurotrophic factor in SK-N-SH neuroblastoma cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 253-61. PMID 7529828 DOI: 10.1523/Jneurosci.15-01-00253.1995  1
1995 Riddle DR, Lo DC, Katz LC. NT-4-mediated rescue of lateral geniculate neurons from effects of monocular deprivation. Nature. 378: 189-91. PMID 7477322 DOI: 10.1038/378189a0  1
1994 Pecorino LT, Lo DC, Brockes JP. Isoform-specific induction of a retinoid-responsive antigen after biolistic transfection of chimaeric retinoic acid/thyroid hormone receptors into a regenerating limb. Development (Cambridge, England). 120: 325-33. PMID 8149912  1
1994 Lo DC, McAllister AK, Katz LC. Neuronal transfection in brain slices using particle-mediated gene transfer. Neuron. 13: 1263-8. PMID 7993619 DOI: 10.1016/0896-6273(94)90412-X  1
1994 Brockes JP, Lo DC. Reversibility of the mononucleate-to-multinucleate myogenic transition during amphibian limb regeneration. Eye (London, England). 8: 151-4. PMID 7958014 DOI: 10.1038/Eye.1994.38  1
1993 Lo DC. A central role for ciliary neurotrophic factor? Proceedings of the National Academy of Sciences of the United States of America. 90: 2557-8. PMID 8385335 DOI: 10.1073/Pnas.90.7.2557  1
1993 Lo DC, Allen F, Brockes JP. Reversal of muscle differentiation during urodele limb regeneration. Proceedings of the National Academy of Sciences of the United States of America. 90: 7230-4. PMID 8346239 DOI: 10.1073/Pnas.90.15.7230  1
1992 Pecorino LT, Lo DC. Having a blast with gene transfer. Current Biology : Cb. 2: 30-2. PMID 15336065 DOI: 10.1016/0960-9822(92)90421-6  1
1992 Lo DC. NGF takes shape. Current Biology : Cb. 2: 67-9. PMID 15335999 DOI: 10.1016/0960-9822(92)90197-I  1
1992 Lo DC. Signal transduction and regulation of neurotrophins. Current Opinion in Neurobiology. 2: 336-40. PMID 1353699 DOI: 10.1016/0959-4388(92)90125-5  1
1991 Lo DC, Pinkham JL, Stevens CF. Role of a key cysteine residue in the gating of the acetylcholine receptor. Neuron. 6: 31-40. PMID 1986773 DOI: 10.1016/0896-6273(91)90119-K  1
1990 Lo DC, Pinkham JL, Stevens CF. Influence of the gamma subunit and expression system on acetylcholine receptor gating. Neuron. 5: 857-66. PMID 1702647 DOI: 10.1016/0896-6273(90)90345-G  1
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