Husseini K. Manji - Publications

Affiliations: 
Laboratory of Molecular Pathophysiology and Experimental Therapeutics National Institute of Mental Health (NIMH) 

226 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Machado-Vieira R, Courtes AC, Zarate CA, Henter ID, Manji HK. Non-canonical pathways in the pathophysiology and therapeutics of bipolar disorder. Frontiers in Neuroscience. 17: 1228455. PMID 37592949 DOI: 10.3389/fnins.2023.1228455  0.379
2020 Ness S, Pandina G, Jagannatha S, Wathen K, Bangerter A, Manyakov NV, Hendren R, Leventhal B, Murphy D, Dawson G, Drevets WC, Manji HK. ASPI: a public-private partnership to develop treatments for autism. Nature Reviews. Drug Discovery. 19: 219-220. PMID 32242150 DOI: 10.1038/D41573-020-00012-4  0.361
2019 Popova V, Daly EJ, Trivedi M, Cooper K, Lane R, Lim P, Mazzucco C, Hough D, Thase ME, Shelton RC, Molero P, Vieta E, Bajbouj M, Manji H, Drevets WC, et al. Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study. The American Journal of Psychiatry. appiajp201919020172. PMID 31109201 DOI: 10.1176/Appi.Ajp.2019.19020172  0.332
2018 Ochs-Ross R, Daly EJ, Zhang Y, Lane R, Lim P, Foster K, Hough D, Manji H, Drevets WC, Sanacora G, Adler C, McShane R, Gaillard R, Singh JB. S114. Efficacy and Safety of Intranasal Esketamine Plus an Oral Antidepressant in Elderly Patients With Treatment-Resistant Depression Biological Psychiatry. 83. DOI: 10.1016/J.Biopsych.2018.02.1005  0.31
2018 Popova V, Daly E, Trivedi M, Cooper K, Lane R, Lim P, Mazzucco C, Hough D, Thase M, Shelton R, Molero P, Vieta E, Bajbouj M, Manji H, Drevets W, et al. S111. Randomized, Double-Blind Study of Flexibly-Dosed Intranasal Esketamine Plus Oral Antidepressant Vs. Active Control in Treatment-Resistant Depression Biological Psychiatry. 83. DOI: 10.1016/J.Biopsych.2018.02.1002  0.306
2017 Tobe BTD, Crain AM, Winquist AM, Calabrese B, Makihara H, Zhao WN, Lalonde J, Nakamura H, Konopaske G, Sidor M, Pernia CD, Yamashita N, Wada M, Inoue Y, Nakamura F, ... ... Manji H, et al. Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28500272 DOI: 10.1073/Pnas.1700111114  0.423
2016 Breen G, Li Q, Roth BL, O'Donnell P, Didriksen M, Dolmetsch R, O'Reilly PF, Gaspar HA, Manji H, Huebel C, Kelsoe JR, Malhotra D, Bertolino A, Posthuma D, Sklar P, et al. Translating genome-wide association findings into new therapeutics for psychiatry. Nature Neuroscience. 19: 1392-1396. PMID 27786187 DOI: 10.1038/Nn.4411  0.319
2016 Singh JB, Fedgchin M, Daly EJ, De Boer P, Cooper K, Lim P, Pinter C, Murrough JW, Sanacora G, Shelton RC, Kurian B, Winokur A, Fava M, Manji H, Drevets WC, et al. A Double-Blind, Randomized, Placebo-Controlled, Dose-Frequency Study of Intravenous Ketamine in Patients With Treatment-Resistant Depression. The American Journal of Psychiatry. appiajp201616010037. PMID 27056608 DOI: 10.1176/Appi.Ajp.2016.16010037  0.324
2016 Zarate CA, Quiroz J, Payne J, Manji HK. Modulators of the glutamatergic system: implications for the development of improved therapeutics in mood disorders. Psychopharmacology Bulletin. 36: 35-83. PMID 12858143  0.343
2015 Bredt DS, Furey ML, Chen G, Lovenberg T, Drevets WC, Manji HK. Translating depression biomarkers for improved targeted therapies. Neuroscience and Biobehavioral Reviews. PMID 26432926 DOI: 10.1016/j.neubiorev.2015.09.013  0.324
2015 Schubert CR, O'Donnell P, Quan J, Wendland JR, Xi HS, Winslow AR, Domenici E, Essioux L, Kam-Thong T, Airey DC, Calley JN, Collier DA, Wang H, Eastwood B, Ebert P, ... ... Manji H, et al. BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders Neuron. 88: 1078-1083. DOI: 10.1016/J.Neuron.2015.10.047  0.42
2014 de Sousa RT, Machado-Vieira R, Zarate CA, Manji HK. Targeting mitochondrially mediated plasticity to develop improved therapeutics for bipolar disorder. Expert Opinion On Therapeutic Targets. 18: 1131-47. PMID 25056514 DOI: 10.1517/14728222.2014.940893  0.42
2012 Kaddurah-Daouk R, Yuan P, Boyle SH, Matson W, Wang Z, Zeng ZB, Zhu H, Dougherty GG, Yao JK, Chen G, Guitart X, Carlson PJ, Neumeister A, Zarate C, Krishnan RR, ... Manji HK, et al. Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile. Scientific Reports. 2: 667. PMID 22993692 DOI: 10.1038/Srep00667  0.374
2012 Manji HK, Hsiao JK, Risby ED, Osman OT, Rudorfer MV, Potter WZ. ECT treatment does not enhance neuroendocrine responses to serotonergic challenge. Journal of Psychopharmacology (Oxford, England). 6: 501-8. PMID 22291398 DOI: 10.1177/026988119200600405  0.304
2012 Koss WA, Einat H, Schloesser RJ, Manji HK, Rubinow DR. Estrogen effects on the forced swim test differ in two outbred rat strains. Physiology & Behavior. 106: 81-6. PMID 22266677 DOI: 10.1016/J.Physbeh.2012.01.004  0.3
2012 de Bartolomeis A, Tomasetti C, Cicale M, Yuan PX, Manji HK. Chronic treatment with lithium or valproate modulates the expression of Homer1b/c and its related genes Shank and Inositol 1,4,5-trisphosphate receptor. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 22: 527-35. PMID 22245542 DOI: 10.1016/J.Euroneuro.2011.11.006  0.362
2012 Schloesser RJ, Martinowich K, Manji HK. Mood-stabilizing drugs: mechanisms of action. Trends in Neurosciences. 35: 36-46. PMID 22217451 DOI: 10.1016/j.tins.2011.11.009  0.309
2012 Quiroz JA, Manji HK. Enhancing synaptic plasticity and cellular resilience to develop novel, improved treatments for mood disorders. Dialogues in Clinical Neuroscience. 4: 73-92. PMID 22034240  0.408
2012 Charney DS, Dejesus G, Manji HK. Cellular plasticity and resilience and the pathophysiology of severe mood disorders. Dialogues in Clinical Neuroscience. 6: 217-25. PMID 22033657  0.394
2012 Malkesman O, Austin DR, Tragon T, Wang G, Rompala G, Hamidi AB, Cui Z, Young WS, Nakazawa K, Zarate CA, Manji HK, Chen G. Acute D-serine treatment produces antidepressant-like effects in rodents. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 15: 1135-48. PMID 21906419 DOI: 10.1017/S1461145711001386  0.36
2011 Machado-Vieira R, Manji HK, Zarate CA. Potential novel therapeutics for bipolar disorders. Current Topics in Behavioral Neurosciences. 5: 303-29. PMID 25236562 DOI: 10.1007/7854_2010_51  0.369
2011 Nanavati D, Austin DR, Catapano LA, Luckenbaugh DA, Dosemeci A, Manji HK, Chen G, Markey SP. The effects of chronic treatment with mood stabilizers on the rat hippocampal post-synaptic density proteome. Journal of Neurochemistry. 119: 617-29. PMID 21838781 DOI: 10.1111/J.1471-4159.2011.07424.X  0.418
2011 Malkesman O, Austin DR, Tragon T, Henter ID, Reed JC, Pellecchia M, Chen G, Manji HK. Targeting the BH3-interacting domain death agonist to develop mechanistically unique antidepressants. Molecular Psychiatry. 17: 770-80. PMID 21727899 DOI: 10.1038/Mp.2011.77  0.377
2011 Creson TK, Austin DR, Shaltiel G, Mccammon J, Wess J, Manji HK, Chen G. Lithium treatment attenuates muscarinic M1 receptor dysfunction Bipolar Disorders. 13: 238-249. PMID 21676127 DOI: 10.1111/J.1399-5618.2011.00915.X  0.326
2011 Mah L, Zarate CA, Nugent AC, Singh JB, Manji HK, Drevets WC. Neural mechanisms of antidepressant efficacy of the dopamine receptor agonist pramipexole in treatment of bipolar depression International Journal of Neuropsychopharmacology. 14: 545-551. PMID 21029512 DOI: 10.1017/S1461145710001203  0.387
2011 Machado-Vieira R, Manji HK, Zarate CA. Potential novel therapeutics for bipolar disorders Current Topics in Behavioral Neurosciences. 5: 303-329. DOI: 10.1007/7854_2010_51  0.316
2010 Diazgranados N, Ibrahim L, Brutsche NE, Newberg A, Kronstein P, Khalife S, Kammerer WA, Quezado Z, Luckenbaugh DA, Salvadore G, Machado-Vieira R, Manji HK, Zarate CA. A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression Archives of General Psychiatry. 67: 793-802. PMID 20679587 DOI: 10.1001/Archgenpsychiatry.2010.90  0.355
2010 Du J, Wei Y, Liu L, Wang Y, Khairova R, Blumenthal R, Tragon T, Hunsberger JG, Machado-Vieira R, Drevets W, Wang YT, Manji HK. A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. Proceedings of the National Academy of Sciences of the United States of America. 107: 11573-8. PMID 20534517 DOI: 10.1073/Pnas.0913138107  0.451
2010 Salvadore G, Quiroz JA, Machado-Vieira R, Henter ID, Manji HK, Zarate CA. The neurobiology of the switch process in bipolar disorder: A review Journal of Clinical Psychiatry. 71: 1488-1501. PMID 20492846 DOI: 10.4088/Jcp.09R05259Gre  0.407
2010 Quiroz JA, MacHado-Vieira R, Zarate CA, Manji HK. Novel insights into lithium's mechanism of action: Neurotrophic and neuroprotective effects Neuropsychobiology. 62: 50-60. PMID 20453535 DOI: 10.1159/000314310  0.435
2010 Cornwell BR, Salvadore G, Colon-Rosario V, Latov DR, Holroyd T, Carver FW, Coppola R, Manji HK, Zarate CA, Grillon C. Abnormal hippocampal functioning and impaired spatial navigation in depressed individuals: evidence from whole-head magnetoencephalography. The American Journal of Psychiatry. 167: 836-44. PMID 20439387 DOI: 10.1176/Appi.Ajp.2009.09050614  0.356
2010 Schloesser RJ, Lehmann M, Martinowich K, Manji HK, Herkenham M. Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress. Molecular Psychiatry. 15: 1152-63. PMID 20308988 DOI: 10.1038/Mp.2010.34  0.302
2010 Chen G, Henter ID, Manji HK. Translational research in bipolar disorder: emerging insights from genetically based models. Molecular Psychiatry. 15: 883-95. PMID 20142820 DOI: 10.1038/Mp.2010.3  0.418
2010 Laje G, Cannon DM, Allen AS, Klaver JM, Peck SA, Liu X, Manji HK, Drevets WC, McMahon FJ. Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 13: 715-24. PMID 20047709 DOI: 10.1017/S1461145709991027  0.323
2010 Yuan P, Zhou R, Wang Y, Li X, Li J, Chen G, Guitart X, Manji HK. Altered levels of extracellular signal-regulated kinase signaling proteins in postmortem frontal cortex of individuals with mood disorders and schizophrenia. Journal of Affective Disorders. 124: 164-9. PMID 19913919 DOI: 10.1016/J.Jad.2009.10.017  0.489
2010 Schloesser RJ, Lan M, Manji HK. Neurodegeneration in Psychiatric Illness Encyclopedia of Neuroscience. 279-283. DOI: 10.1016/B978-008045046-9.00513-1  0.334
2010 Machado-Vieira R, Manji HK, Zarate CA. Novel Therapeutic Strategies for Bipolar Disorder Bipolar Disorder: Clinical and Neurobiological Foundations. 395-411. DOI: 10.1002/9780470661277.ch30  0.314
2009 Zhou R, Holmes A, Du J, Malkesman O, Yuan P, Wang Y, Damschroder-Williams P, Chen G, Guitart X, Manji HK. Genome-wide gene expression profiling in GluR1 knockout mice: Key role of the calcium signaling pathway in glutamatergically mediated hippocampal transmission European Journal of Neuroscience. 30: 2318-2326. PMID 20092574 DOI: 10.1111/J.1460-9568.2009.07022.X  0.3
2009 Chen G, Henter ID, Manji HK. A role for PKC in mediating stress-induced prefrontal cortical structural plasticity and cognitive function. Proceedings of the National Academy of Sciences of the United States of America. 106: 17613-4. PMID 19828441 DOI: 10.1073/Pnas.0909771106  0.356
2009 Machado-Vieira R, Yuan P, Brutsche N, DiazGranados N, Luckenbaugh D, Manji HK, Zarate CA. Brain-derived neurotrophic factor and initial antidepressant response to an N-methyl-D-aspartate antagonist Journal of Clinical Psychiatry. 70: 1662-1666. PMID 19744406 DOI: 10.4088/Jcp.08M04659  0.365
2009 Laje G, Allen AS, Akula N, Manji H, John Rush A, McMahon FJ. Genome-wide association study of suicidal ideation emerging during citalopram treatment of depressed outpatients. Pharmacogenetics and Genomics. 19: 666-74. PMID 19724244 DOI: 10.1097/Fpc.0B013E32832E4Bcd  0.311
2009 Hunsberger JG, Austin DR, Chen G, Manji HK. Cellular mechanisms underlying affective resiliency: the role of glucocorticoid receptor- and mitochondrially-mediated plasticity. Brain Research. 1293: 76-84. PMID 19595676 DOI: 10.1016/J.Brainres.2009.06.103  0.448
2009 Zarate CA, Manji HK. Protein kinase C inhibitors: Rationale for use and potential in the treatment of bipolar disorder Cns Drugs. 23: 569-582. PMID 19552485 DOI: 10.2165/00023210-200923070-00003  0.503
2009 Hunsberger JG, Austin DR, Chen G, Manji HK. MicroRNAs in mental health: from biological underpinnings to potential therapies. Neuromolecular Medicine. 11: 173-82. PMID 19544012 DOI: 10.1007/S12017-009-8070-5  0.376
2009 Machado-Vieira R, Manji HK, Zarate CA. The role of lithium in the treatment of bipolar disorder: Convergent evidence for neurotrophic effects as a unifying hypothesis Bipolar Disorders. 11: 92-109. PMID 19538689 DOI: 10.1111/J.1399-5618.2009.00714.X  0.382
2009 Creson TK, Hao Y, Engel S, Shen Y, Hamidi A, Zhuo M, Manji HK, Chen G. The anterior cingulate ERK pathway contributes to regulation of behavioral excitement and hedonic activity. Bipolar Disorders. 11: 339-50. PMID 19500087 DOI: 10.1111/J.1399-5618.2009.00697.X  0.373
2009 MacHado-Vieira R, Manji HK, Zarate CA. The role of the tripartite glutamatergic synapse in the pathophysiology and therapeutics of mood disorders Neuroscientist. 15: 525-539. PMID 19471044 DOI: 10.1177/1073858409336093  0.303
2009 Yuan P, Salvadore G, Li X, Zhang L, Du J, Chen G, Manji HK. Valproate activates the Notch3/c-FLIP signaling cascade: a strategy to attenuate white matter hyperintensities in bipolar disorder in late life? Bipolar Disorders. 11: 256-69. PMID 19419383 DOI: 10.1111/J.1399-5618.2009.00675.X  0.431
2009 Malkesman O, Austin DR, Chen G, Manji HK. Reverse translational strategies for developing animal models of bipolar disorder. Disease Models & Mechanisms. 2: 238-45. PMID 19407332 DOI: 10.1242/Dmm.001628  0.416
2009 Moore GJ, Cortese BM, Glitz DA, Zajac-Benitez C, Quiroz JA, Uhde TW, Drevets WC, Manji HK. A longitudinal study of the effects of lithium treatment on prefrontal and subgenual prefrontal gray matter volume in treatment-responsive bipolar disorder patients. The Journal of Clinical Psychiatry. 70: 699-705. PMID 19389332 DOI: 10.4088/Jcp.07M03745  0.449
2009 Martinowich K, Schloesser RJ, Manji HK. Bipolar disorder: from genes to behavior pathways. The Journal of Clinical Investigation. 119: 726-36. PMID 19339764 DOI: 10.1172/Jci37703  0.434
2009 Malkesman O, Pine DS, Tragon T, Austin DR, Henter ID, Chen G, Manji HK. Animal models of suicide-trait-related behaviors. Trends in Pharmacological Sciences. 30: 165-73. PMID 19269045 DOI: 10.1016/J.Tips.2009.01.004  0.314
2009 Khairova RA, Machado-Vieira R, Du J, Manji HK. A potential role for pro-inflammatory cytokines in regulating synaptic plasticity in major depressive disorder. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 12: 561-78. PMID 19224657 DOI: 10.1017/S1461145709009924  0.388
2009 Du J, Wang Y, Hunter R, Wei Y, Blumenthal R, Falke C, Khairova R, Zhou R, Yuan P, Machado-Vieira R, McEwen BS, Manji HK. Dynamic regulation of mitochondrial function by glucocorticoids. Proceedings of the National Academy of Sciences of the United States of America. 106: 3543-8. PMID 19202080 DOI: 10.1073/Pnas.0812671106  0.312
2009 Salvadore G, Cornwell BR, Colon-Rosario V, Coppola R, Grillon C, Zarate CA, Manji HK. Increased anterior cingulate cortical activity in response to fearful faces: a neurophysiological biomarker that predicts rapid antidepressant response to ketamine. Biological Psychiatry. 65: 289-95. PMID 18822408 DOI: 10.1016/J.Biopsych.2008.08.014  0.354
2009 Szabo ST, Machado-Vieira R, Yuan P, Wang Y, Wei Y, Falke C, Cirelli C, Tononi G, Manji HK, Du J. Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania. Neuropharmacology. 56: 47-55. PMID 18789340 DOI: 10.1016/J.Neuropharm.2008.08.015  0.416
2009 Creson TK, Yuan P, Manji HK, Chen G. Evidence for involvement of ERK, PI3K, and RSK in induction of Bcl-2 by valproate. Journal of Molecular Neuroscience : Mn. 37: 123-34. PMID 18677583 DOI: 10.1007/S12031-008-9122-2  0.358
2009 Lan MJ, McLoughlin GA, Griffin JL, Tsang TM, Huang JT, Yuan P, Manji H, Holmes E, Bahn S. Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder. Molecular Psychiatry. 14: 269-79. PMID 18256615 DOI: 10.1038/Sj.Mp.4002130  0.402
2009 Engel SR, Creson TK, Hao Y, Shen Y, Maeng S, Nekrasova T, Landreth GE, Manji HK, Chen G. The extracellular signal-regulated kinase pathway contributes to the control of behavioral excitement Molecular Psychiatry. 14: 448-461. PMID 18227838 DOI: 10.1038/Sj.Mp.4002135  0.413
2008 Salvadore G, Drevets WC, Henter ID, Zarate CA, Manji HK. Early intervention in bipolar disorder, part II: therapeutics. Early Intervention in Psychiatry. 2: 136-46. PMID 19649153 DOI: 10.1111/J.1751-7893.2008.00072.X  0.393
2008 Salvadore G, Drevets WC, Henter ID, Zarate CA, Manji HK. Early intervention in bipolar disorder, part I: clinical and imaging findings. Early Intervention in Psychiatry. 2: 122-35. PMID 19649152 DOI: 10.1111/J.1751-7893.2008.00071.X  0.384
2008 Mallinger AG, Thase ME, Haskett R, Buttenfield J, Luckenbaugh DA, Frank E, Kupfer DJ, Manji HK. Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms. Bipolar Disorders. 10: 856-66. PMID 19594501 DOI: 10.1111/J.1399-5618.2008.00636.X  0.374
2008 Gelenberg AJ, Thase ME, Meyer RE, Goodwin FK, Katz MM, Kraemer HC, Potter WZ, Shelton RC, Fava M, Khan A, Trivedi MH, Ninan PT, Mann JJ, Bergeson S, Endicott J, ... ... Manji HK, et al. The history and current state of antidepressant clinical trial design: a call to action for proof-of-concept studies. The Journal of Clinical Psychiatry. 69: 1513-28. PMID 19192434 DOI: 10.4088/Jcp.V69N1001  0.334
2008 Holmes MK, Erickson K, Luckenbaugh DA, Drevets WC, Bain EE, Cannon DM, Snow J, Sahakian BJ, Manji HK, Zarate CA. A comparison of cognitive functioning in medicated and unmedicated subjects with bipolar depression. Bipolar Disorders. 10: 806-15. PMID 19032712 DOI: 10.1111/J.1399-5618.2008.00628.X  0.343
2008 Zarate CA, Manji HK. Riluzole in psychiatry: a systematic review of the literature. Expert Opinion On Drug Metabolism & Toxicology. 4: 1223-34. PMID 18721116 DOI: 10.1517/17425255.4.9.1223  0.423
2008 Zarate CA, Manji HK. Bipolar disorder: candidate drug targets. The Mount Sinai Journal of Medicine, New York. 75: 226-47. PMID 18704977 DOI: 10.1002/Msj.20042  0.461
2008 Maeng S, Hunsberger JG, Pearson B, Yuan P, Wang Y, Wei Y, McCammon J, Schloesser RJ, Zhou R, Du J, Chen G, McEwen B, Reed JC, Manji HK. BAG1 plays a critical role in regulating recovery from both manic-like and depression-like behavioral impairments. Proceedings of the National Academy of Sciences of the United States of America. 105: 8766-71. PMID 18562287 DOI: 10.1073/Pnas.0803736105  0.35
2008 Lan MJ, Yuan P, Chen G, Manji HK. Neuronal peroxisome proliferator-activated receptor gamma signaling: regulation by mood-stabilizer valproate. Journal of Molecular Neuroscience : Mn. 35: 225-34. PMID 18437585 DOI: 10.1007/S12031-008-9056-8  0.406
2008 Machado-Vieira R, Salvadore G, Luckenbaugh DA, Manji HK, Zarate CA. Rapid onset of antidepressant action: a new paradigm in the research and treatment of major depressive disorder. The Journal of Clinical Psychiatry. 69: 946-58. PMID 18435563 DOI: 10.4088/Jcp.V69N0610  0.37
2008 Sanacora G, Zarate CA, Krystal JH, Manji HK. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nature Reviews. Drug Discovery. 7: 426-37. PMID 18425072 DOI: 10.1038/Nrd2462  0.456
2008 Catapano LA, Manji HK. Kinases as drug targets in the treatment of bipolar disorder. Drug Discovery Today. 13: 295-302. PMID 18405841 DOI: 10.1016/J.Drudis.2008.02.007  0.476
2008 Shaltiel G, Maeng S, Malkesman O, Pearson B, Schloesser RJ, Tragon T, Rogawski M, Gasior M, Luckenbaugh D, Chen G, Manji HK. Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania. Molecular Psychiatry. 13: 858-72. PMID 18332879 DOI: 10.1038/Mp.2008.20  0.332
2008 Gould TD, O'Donnell KC, Picchini AM, Dow ER, Chen G, Manji HK. Generation and behavioral characterization of beta-catenin forebrain-specific conditional knock-out mice. Behavioural Brain Research. 189: 117-25. PMID 18299155 DOI: 10.1016/J.Bbr.2007.12.028  0.604
2008 Marx CE, Yuan P, Kilts JD, Madison RD, Shampine LJ, Manji HK. Neuroactive steroids, mood stabilizers, and neuroplasticity: alterations following lithium and changes in Bcl-2 knockout mice. The International Journal of Neuropsychopharmacology. 11: 547-52. PMID 18257969 DOI: 10.1017/S1461145708008444  0.348
2008 Lekman M, Laje G, Charney D, Rush AJ, Wilson AF, Sorant AJ, Lipsky R, Wisniewski SR, Manji H, McMahon FJ, Paddock S. The FKBP5-gene in depression and treatment response--an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort. Biological Psychiatry. 63: 1103-10. PMID 18191112 DOI: 10.1016/J.Biopsych.2007.10.026  0.336
2008 Mathew SJ, Manji HK, Charney DS. Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2080-92. PMID 18172433 DOI: 10.1038/Sj.Npp.1301652  0.454
2008 Du J, Creson TK, Wu LJ, Ren M, Gray NA, Falke C, Wei Y, Wang Y, Blumenthal R, Machado-Vieira R, Yuan P, Chen G, Zhuo M, Manji HK. The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 68-79. PMID 18171924 DOI: 10.1523/Jneurosci.3080-07.2008  0.385
2008 Gould TD, O'Donnell KC, Dow ER, Du J, Chen G, Manji HK. Involvement of AMPA receptors in the antidepressant-like effects of lithium in the mouse tail suspension test and forced swim test. Neuropharmacology. 54: 577-87. PMID 18096191 DOI: 10.1016/J.Neuropharm.2007.11.002  0.628
2008 Newberg AR, Catapano LA, Zarate CA, Manji HK. Neurobiology of bipolar disorder. Expert Review of Neurotherapeutics. 8: 93-110. PMID 18088203 DOI: 10.1586/14737175.8.1.93  0.469
2008 Schloesser RJ, Huang J, Klein PS, Manji HK. Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 110-33. PMID 17912251 DOI: 10.1038/Sj.Npp.1301575  0.46
2008 Maeng S, Zarate CA, Du J, Schloesser RJ, McCammon J, Chen G, Manji HK. Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biological Psychiatry. 63: 349-52. PMID 17643398 DOI: 10.1016/J.Biopsych.2007.05.028  0.35
2008 Arnsten A, Manji H. Mania: a rational neurobiology Future Neurology. 3: 125-131. DOI: 10.2217/14796708.3.2.125  0.414
2008 Mathew SJ, Manji HK, Charney DS. Novel drugs and therapeutic targets for severe mood disorders (Neuropsychopharmacology (2008) DOI: 10.1038/sj.npp.1301652) Neuropsychopharmacology. 33: 2300. DOI: 10.1038/Npp.2008.84  0.327
2008 Gould T, Kovacsics C, O'Donnell K, Dow E, Chen G, Manji H. S.20.04 Lithium responsive behavioural models: a tool for understanding atypical antipsychotic action in bipolar depression and mania European Neuropsychopharmacology. 18. DOI: 10.1016/S0924-977X(08)70191-3  0.612
2007 Angst J, Gamma A, Gerber-Werder R, Zarate CA, Manji HK. Does long-term medication with lithium, clozapine or antidepressants prevent or attenuate dementia in bipolar and depressed patients? International Journal of Psychiatry in Clinical Practice. 11: 2-8. PMID 24941269 DOI: 10.1080/13651500600810133  0.37
2007 Laje G, Paddock S, Manji H, Rush AJ, Wilson AF, Charney D, McMahon FJ. Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. The American Journal of Psychiatry. 164: 1530-8. PMID 17898344 DOI: 10.1176/Appi.Ajp.2007.06122018  0.302
2007 Zarate CA, Singh JB, Carlson PJ, Quiroz J, Jolkovsky L, Luckenbaugh DA, Manji HK. Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study. Bipolar Disorders. 9: 561-70. PMID 17845270 DOI: 10.1111/J.1399-5618.2007.00530.X  0.34
2007 Martinowich K, Manji H, Lu B. New insights into BDNF function in depression and anxiety. Nature Neuroscience. 10: 1089-93. PMID 17726474 DOI: 10.1038/Nn1971  0.424
2007 Cannon DM, Ichise M, Rollis D, Klaver JM, Gandhi SK, Charney DS, Manji HK, Drevets WC. Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder. Biological Psychiatry. 62: 870-7. PMID 17678634 DOI: 10.1016/J.Biopsych.2007.03.016  0.389
2007 Einat H, Yuan P, Szabo ST, Dogra S, Manji HK. Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder. Neuropsychobiology. 55: 123-31. PMID 17641532 DOI: 10.1159/000106054  0.447
2007 Hu XZ, Rush AJ, Charney D, Wilson AF, Sorant AJ, Papanicolaou GJ, Fava M, Trivedi MH, Wisniewski SR, Laje G, Paddock S, McMahon FJ, Manji H, Lipsky RH. Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression. Archives of General Psychiatry. 64: 783-92. PMID 17606812 DOI: 10.1001/Archpsyc.64.7.783  0.312
2007 Chuang DM, Manji HK. In search of the Holy Grail for the treatment of neurodegenerative disorders: has a simple cation been overlooked? Biological Psychiatry. 62: 4-6. PMID 17572175 DOI: 10.1016/J.Biopsych.2007.04.008  0.42
2007 Gould TD, Dow ER, O'Donnell KC, Chen G, Manji HK. Targeting signal transduction pathways in the treatment of mood disorders: recent insights into the relevance of the Wnt pathway. Cns & Neurological Disorders Drug Targets. 6: 193-204. PMID 17511616 DOI: 10.2174/187152707780619308  0.689
2007 Agid Y, Buzsáki G, Diamond DM, Frackowiak R, Giedd J, Girault JA, Grace A, Lambert JJ, Manji H, Mayberg H, Popoli M, Prochiantz A, Richter-Levin G, Somogyi P, Spedding M, et al. How can drug discovery for psychiatric disorders be improved? Nature Reviews. Drug Discovery. 6: 189-201. PMID 17330070 DOI: 10.1038/Nrd2217  0.448
2007 Gould NF, Holmes MK, Fantie BD, Luckenbaugh DA, Pine DS, Gould TD, Burgess N, Manji HK, Zarate CA. Performance on a virtual reality spatial memory navigation task in depressed patients. The American Journal of Psychiatry. 164: 516-9. PMID 17329478 DOI: 10.1176/Ajp.2007.164.3.516  0.574
2007 Gould TD, Einat H, O'Donnell KC, Picchini AM, Schloesser RJ, Manji HK. Beta-catenin overexpression in the mouse brain phenocopies lithium-sensitive behaviors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 2173-83. PMID 17299510 DOI: 10.1038/Sj.Npp.1301338  0.595
2007 Schloesser RJ, Chen G, Manji HK. Neurogenesis and neuroenhancement in the pathophysiology and treatment of bipolar disorder. International Review of Neurobiology. 77: 143-78. PMID 17178474 DOI: 10.1016/S0074-7742(06)77005-2  0.435
2007 Kling MA, Alesci S, Csako G, Costello R, Luckenbaugh DA, Bonne O, Duncko R, Drevets WC, Manji HK, Charney DS, Gold PW, Neumeister A. Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A. Biological Psychiatry. 62: 309-13. PMID 17178112 DOI: 10.1016/J.Biopsych.2006.09.033  0.334
2007 Gould TD, O'Donnell KC, Picchini AM, Manji HK. Strain differences in lithium attenuation of d-amphetamine-induced hyperlocomotion: a mouse model for the genetics of clinical response to lithium. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 1321-33. PMID 17151598 DOI: 10.1038/Sj.Npp.1301254  0.565
2007 Catapano LA, Manji HK. G protein-coupled receptors in major psychiatric disorders. Biochimica Et Biophysica Acta. 1768: 976-93. PMID 17078926 DOI: 10.1016/J.Bbamem.2006.09.025  0.454
2007 Alesci S, Rodak M, Ilias I, Zhou R, Manji HK. The genomics of mood disorders. Progress in Brain Research. 158: 129-39. PMID 17027694 DOI: 10.1016/S0079-6123(06)58006-9  0.49
2007 Du J, Suzuki K, Wei Y, Wang Y, Blumenthal R, Chen Z, Falke C, Zarate CA, Manji HK. The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 793-802. PMID 16936714 DOI: 10.1038/Sj.Npp.1301178  0.414
2006 Machado-Vieira R, Zarate CA, Manji HK. Emerging Novel Treatments for Severe Mood Disorders Involving Cellular Plasticity Cascades. Current Psychosis & Therapeutics Reports. 4: 181-190. PMID 25620894 DOI: 10.1007/Bf02629394  0.515
2006 Du J, Machado-Vieira R, Maeng S, Martinowich K, Manji HK, Zarate CA. Enhancing AMPA to NMDA throughput as a convergent mechanism for antidepressant action. Drug Discovery Today. Therapeutic Strategies. 3: 519-526. PMID 25411578 DOI: 10.1016/J.Ddstr.2006.11.012  0.312
2006 Gould TD, Picchini AM, Einat H, Manji HK. Targeting glycogen synthase kinase-3 in the CNS: implications for the development of new treatments for mood disorders. Current Drug Targets. 7: 1399-409. PMID 17100580 DOI: 10.2174/1389450110607011399  0.7
2006 Shaltiel G, Chen G, Manji HK. Neurotrophic signaling cascades in the pathophysiology and treatment of bipolar disorder. Current Opinion in Pharmacology. 7: 22-6. PMID 17055337 DOI: 10.1016/J.Coph.2006.07.005  0.473
2006 Mah L, Zarate CA, Singh J, Duan YF, Luckenbaugh DA, Manji HK, Drevets WC. Regional cerebral glucose metabolic abnormalities in bipolar II depression. Biological Psychiatry. 61: 765-75. PMID 17027930 DOI: 10.1016/J.Biopsych.2006.06.009  0.408
2006 Zarate CA, Singh JB, Carlson PJ, Brutsche NE, Ameli R, Luckenbaugh DA, Charney DS, Manji HK. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Archives of General Psychiatry. 63: 856-64. PMID 16894061 DOI: 10.1001/Archpsyc.63.8.856  0.403
2006 Cannon DM, Ichise M, Fromm SJ, Nugent AC, Rollis D, Gandhi SK, Klaver JM, Charney DS, Manji HK, Drevets WC. Serotonin transporter binding in bipolar disorder assessed using [11C]DASB and positron emission tomography. Biological Psychiatry. 60: 207-17. PMID 16875929 DOI: 10.1016/J.Biopsych.2006.05.005  0.351
2006 McMahon FJ, Buervenich S, Charney D, Lipsky R, Rush AJ, Wilson AF, Sorant AJ, Papanicolaou GJ, Laje G, Fava M, Trivedi MH, Wisniewski SR, Manji H. Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. American Journal of Human Genetics. 78: 804-14. PMID 16642436 DOI: 10.1086/503820  0.362
2006 Chen G, Manji HK. The extracellular signal-regulated kinase pathway: an emerging promising target for mood stabilizers. Current Opinion in Psychiatry. 19: 313-23. PMID 16612219 DOI: 10.1097/01.yco.0000218604.63463.cd  0.367
2006 Carlson PJ, Singh JB, Zarate CA, Drevets WC, Manji HK. Neural circuitry and neuroplasticity in mood disorders: insights for novel therapeutic targets. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 3: 22-41. PMID 16490411 DOI: 10.1016/J.Nurx.2005.12.009  0.477
2006 Zarate CA, Singh J, Manji HK. Cellular plasticity cascades: targets for the development of novel therapeutics for bipolar disorder. Biological Psychiatry. 59: 1006-20. PMID 16487491 DOI: 10.1016/J.Biopsych.2005.10.021  0.487
2006 Einat H, Manji HK. Cellular plasticity cascades: genes-to-behavior pathways in animal models of bipolar disorder. Biological Psychiatry. 59: 1160-71. PMID 16457783 DOI: 10.1016/J.Biopsych.2005.11.004  0.455
2006 Hasler G, Drevets WC, Gould TD, Gottesman II, Manji HK. Toward constructing an endophenotype strategy for bipolar disorders. Biological Psychiatry. 60: 93-105. PMID 16406007 DOI: 10.1016/J.Biopsych.2005.11.006  0.721
2006 Zarate CA, Singh JB, Quiroz JA, De Jesus G, Denicoff KK, Luckenbaugh DA, Manji HK, Charney DS. A double-blind, placebo-controlled study of memantine in the treatment of major depression. The American Journal of Psychiatry. 163: 153-5. PMID 16390905 DOI: 10.1176/Appi.Ajp.163.1.153  0.311
2006 Cannon DM, Ichise M, Fromm S, Nugent AC, Rollis D, Gandhi SK, Klaver JM, Charney DS, Manji HK, Drevets WC. Serotonin transporter binding in major depressive disorder and bipolar disorder assessed using [11C]DASB and positron emission tomography Neuroimage. 31. DOI: 10.1016/J.Neuroimage.2006.04.032  0.396
2005 Bachmann RF, Schloesser RJ, Gould TD, Manji HK. Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics. Molecular Neurobiology. 32: 173-202. PMID 16215281 DOI: 10.1385/Mn:32:2:173  0.694
2005 Zhou R, Zarate CA, Manji HK. Identification of molecular mechanisms underlying mood stabilization through genome-wide gene expression profiling. The International Journal of Neuropsychopharmacology. 9: 263-6. PMID 16207389 DOI: 10.1017/S1461145705006176  0.353
2005 Einat H, Yuan P, Manji HK. Increased anxiety-like behaviors and mitochondrial dysfunction in mice with targeted mutation of the Bcl-2 gene: further support for the involvement of mitochondrial function in anxiety disorders. Behavioural Brain Research. 165: 172-80. PMID 16095731 DOI: 10.1016/J.Bbr.2005.06.012  0.374
2005 Zhou R, Gray NA, Yuan P, Li X, Chen J, Chen G, Damschroder-Williams P, Du J, Zhang L, Manji HK. The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4493-502. PMID 15872096 DOI: 10.1523/Jneurosci.4530-04.2005  0.479
2005 Neumeister A, Charney DS, Belfer I, Geraci M, Holmes C, Sharabi Y, Alim T, Bonne O, Luckenbaugh DA, Manji H, Goldman D, Goldstein DS. Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans. Pharmacogenetics and Genomics. 15: 143-9. PMID 15861038 DOI: 10.1097/01213011-200503000-00002  0.316
2005 Gould TD, Manji HK. Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 1223-37. PMID 15827567 DOI: 10.1038/Sj.Npp.1300731  0.66
2005 Neumeister A, Yuan P, Young TA, Bonne O, Luckenbaugh DA, Charney DS, Manji H. Effects of tryptophan depletion on serum levels of brain-derived neurotrophic factor in unmedicated patients with remitted depression and healthy subjects. The American Journal of Psychiatry. 162: 805-7. PMID 15800160 DOI: 10.1176/Appi.Ajp.162.4.805  0.398
2005 Zarate CA, Quiroz JA, Singh JB, Denicoff KD, De Jesus G, Luckenbaugh DA, Charney DS, Manji HK. An open-label trial of the glutamate-modulating agent riluzole in combination with lithium for the treatment of bipolar depression. Biological Psychiatry. 57: 430-2. PMID 15705360 DOI: 10.1016/J.Biopsych.2004.11.023  0.411
2005 Gould TD, Manji HK. DARPP-32: A molecular switch at the nexus of reward pathway plasticity. Proceedings of the National Academy of Sciences of the United States of America. 102: 253-4. PMID 15632217 DOI: 10.1073/Pnas.0408700102  0.584
2005 Quiroz JA, Singh J, Gould TD, Denicoff KD, Zarate CA, Manji HK. Emerging experimental therapeutics for bipolar disorder: clues from the molecular pathophysiology. Molecular Psychiatry. 9: 756-76. PMID 15136795 DOI: 10.1038/Sj.Mp.4001521  0.659
2005 Gould TD, Quiroz JA, Singh J, Zarate CA, Manji HK. Emerging experimental therapeutics for bipolar disorder: insights from the molecular and cellular actions of current mood stabilizers. Molecular Psychiatry. 9: 734-55. PMID 15136794 DOI: 10.1038/Sj.Mp.4001518  0.652
2005 Manji H. S14 IMPAIRMENTS OF CELLULAR PLASTICITY AND RESILIENCE IN SEVERE MOOD DISORDERS: THERAPEUTIC IMPLICATIONS Behavioural Pharmacology. 16: S5. DOI: 10.1097/00008877-200509001-00014  0.306
2005 Yuan PX, Zhou R, Farzad N, Gould TD, Gray NA, Du J, Manji HK. Chapter 5.7 Enhancing resilience to stress: the role of signaling cascades Techniques in the Behavioral and Neural Sciences. 15: 751-771. DOI: 10.1016/S0921-0709(05)80040-9  0.622
2005 Zarate CA, Singh JB, Carlson PJ, Manji HK. Molecular mechanisms of bipolar disorder Drug Discovery Today: Disease Mechanisms. 2: 435-445. DOI: 10.1016/J.Ddmec.2005.11.005  0.464
2004 Du J, Quiroz JA, Gray NA, Szabo ST, Zarate CA, Manji HK. Regulation of cellular plasticity and resilience by mood stabilizers: the role of AMPA receptor trafficking. Dialogues in Clinical Neuroscience. 6: 143-55. PMID 22034247  0.326
2004 Du J, Quiroz J, Yuan P, Zarate C, Manji HK. Bipolar disorder: involvement of signaling cascades and AMPA receptor trafficking at synapses. Neuron Glia Biology. 1: 231-43. PMID 18634600 DOI: 10.1017/S1740925X05000098  0.475
2004 Einat H, Chen G, Manji H. [Possible involvement of protein kinase C in the pathophysiology and treatment of bipolar disorder]. Harefuah. 143: 420-5, 462. PMID 15524099  0.407
2004 Birnbaum SG, Yuan PX, Wang M, Vijayraghavan S, Bloom AK, Davis DJ, Gobeske KT, Sweatt JD, Manji HK, Arnsten AF. Protein kinase C overactivity impairs prefrontal cortical regulation of working memory. Science (New York, N.Y.). 306: 882-4. PMID 15514161 DOI: 10.1126/Science.1100021  0.314
2004 Quiroz JA, Gould TD, Manji HK. Molecular effects of lithium. Molecular Interventions. 4: 259-72. PMID 15471909 DOI: 10.1124/Mi.4.5.6  0.691
2004 Gould TD, Einat H, Bhat R, Manji HK. AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. The International Journal of Neuropsychopharmacology. 7: 387-90. PMID 15315719 DOI: 10.1017/S1461145704004535  0.64
2004 Hao Y, Creson T, Zhang L, Li P, Du F, Yuan P, Gould TD, Manji HK, Chen G. Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6590-9. PMID 15269271 DOI: 10.1523/Jneurosci.5747-03.2004  0.643
2004 Du J, Gray NA, Falke CA, Chen W, Yuan P, Szabo ST, Einat H, Manji HK. Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6578-89. PMID 15269270 DOI: 10.1523/Jneurosci.1258-04.2004  0.369
2004 Zarate CA, Payne JL, Singh J, Quiroz JA, Luckenbaugh DA, Denicoff KD, Charney DS, Manji HK. Pramipexole for bipolar II depression: a placebo-controlled proof of concept study. Biological Psychiatry. 56: 54-60. PMID 15219473 DOI: 10.1016/J.Biopsych.2004.03.013  0.398
2004 Hasler G, Drevets WC, Manji HK, Charney DS. Discovering endophenotypes for major depression. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 1765-81. PMID 15213704 DOI: 10.1038/Sj.Npp.1300506  0.362
2004 Ozerdem A, Schmidt ME, Manji HK, Risinger RC, Potter WZ. Chronic lithium administration enhances noradrenergic responses to intravenous administration of the alpha2 antagonist idazoxan in healthy volunteers. Journal of Clinical Psychopharmacology. 24: 150-4. PMID 15206661 DOI: 10.1097/01.Jcp.0000115667.45074.9F  0.325
2004 Gould TD, Manji HK. The molecular medicine revolution and psychiatry: bridging the gap between basic neuroscience research and clinical psychiatry. The Journal of Clinical Psychiatry. 65: 598-604. PMID 15163244 DOI: 10.4088/Jcp.V65N0502  0.584
2004 Du J, Szabo ST, Gray NA, Manji HK. Focus on CaMKII: a molecular switch in the pathophysiology and treatment of mood and anxiety disorders. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 7: 243-8. PMID 15154976 DOI: 10.1017/S1461145704004432  0.401
2004 Charney DS, Manji HK. Life stress, genes, and depression: multiple pathways lead to increased risk and new opportunities for intervention Science's Stke : Signal Transduction Knowledge Environment. 2004. PMID 15039492 DOI: 10.1126/Stke.2252004Re5  0.403
2004 Gould TD, Zarate CA, Manji HK. Glycogen synthase kinase-3: a target for novel bipolar disorder treatments. The Journal of Clinical Psychiatry. 65: 10-21. PMID 14744163  0.653
2004 Zarate CA, Payne JL, Quiroz J, Sporn J, Denicoff KK, Luckenbaugh D, Charney DS, Manji HK. An open-label trial of riluzole in patients with treatment-resistant major depression. The American Journal of Psychiatry. 161: 171-4. PMID 14702270 DOI: 10.1176/Appi.Ajp.161.1.171  0.324
2004 Einat H, Manji HK, Gould TD, Du J, Chen G. Possible involvement of the ERK signaling cascade in bipolar disorder: behavioral leads from the study of mutant mice. Drug News & Perspectives. 16: 453-63. PMID 14668941 DOI: 10.1358/DNP.2003.16.7.829357  0.623
2004 Gould TD, Chen G, Manji HK. In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 32-8. PMID 12942141 DOI: 10.1038/Sj.Npp.1300283  0.633
2004 Picchini AM, Manji HK, Gould TD. GSK-3 and neurotrophic signaling: novel targets underlying the pathophysiology and treatment of mood disorders? Drug Discovery Today: Disease Mechanisms. 1: 419-428. DOI: 10.1016/J.Ddmec.2004.11.020  0.687
2004 Yuan P, Gould TD, Gray NA, Bachmann RF, Schloesser RJ, Lan MJK, Du J, Moore GJ, Manji HK. Neurotrophic signaling cascades are major long-term targets for lithium: Clinical implications Clinical Neuroscience Research. 4: 137-153. DOI: 10.1016/J.Cnr.2004.09.006  0.679
2004 Gould TD, Zarate CA, Manji HK. Glycogen synthase kinase-3: a target for novel bipolar disorder treatments. The Journal of Clinical Psychiatry. 65: 10-21. DOI: 10.1002/0470052171.Ch7  0.684
2003 Manji HK, Quiroz JA, Payne JL, Singh J, Lopes BP, Viegas JS, Zarate CA. The underlying neurobiology of bipolar disorder. World Psychiatry : Official Journal of the World Psychiatric Association (Wpa). 2: 136-46. PMID 16946919  0.391
2003 Du J, Gray NA, Falke C, Yuan P, Szabo S, Manji HK. Structurally dissimilar antimanic agents modulate synaptic plasticity by regulating AMPA glutamate receptor subunit GluR1 synaptic expression. Annals of the New York Academy of Sciences. 1003: 378-80. PMID 14684466 DOI: 10.1196/Annals.1300.031  0.346
2003 Zarate CA, Du J, Quiroz J, Gray NA, Denicoff KD, Singh J, Charney DS, Manji HK. Regulation of cellular plasticity cascades in the pathophysiology and treatment of mood disorders: role of the glutamatergic system. Annals of the New York Academy of Sciences. 1003: 273-91. PMID 14684452 DOI: 10.1196/Annals.1300.017  0.493
2003 Manji HK, Gottesman II, Gould TD. Signal transduction and genes-to-behaviors pathways in psychiatric diseases. Science's Stke : Signal Transduction Knowledge Environment. 2003: pe49. PMID 14600293 DOI: 10.1126/Stke.2003.207.Pe49  0.703
2003 Ketter TA, Manji HK, Post RM. Potential mechanisms of action of lamotrigine in the treatment of bipolar disorders. Journal of Clinical Psychopharmacology. 23: 484-95. PMID 14520126 DOI: 10.1097/01.jcp.0000088915.02635.e8  0.338
2003 Einat H, Yuan P, Gould TD, Li J, Du J, Zhang L, Manji HK, Chen G. The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7311-6. PMID 12917364 DOI: 10.1523/Jneurosci.23-19-07311.2003  0.653
2003 Dick DM, Foroud T, Flury L, Bowman ES, Miller MJ, Rau NL, Moe PR, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Hahn R, Widmark C, et al. Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative. American Journal of Human Genetics. 73: 107-14. PMID 12772088 DOI: 10.1086/376562  0.353
2003 Gould TD, Gray NA, Manji HK. Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice. Pharmacological Research. 48: 49-53. PMID 12770514 DOI: 10.1016/S1043-6618(03)00096-3  0.637
2003 Gray NA, Zhou R, Du J, Moore GJ, Manji HK. The use of mood stabilizers as plasticity enhancers in the treatment of neuropsychiatric disorders. The Journal of Clinical Psychiatry. 64: 3-17. PMID 12720479  0.398
2003 Manji HK, Quiroz JA, Sporn J, Payne JL, Denicoff K, A Gray N, Zarate CA, Charney DS. Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression. Biological Psychiatry. 53: 707-42. PMID 12706957 DOI: 10.1016/S0006-3223(03)00117-3  0.494
2003 Li J, Gould TD, Yuan P, Manji HK, Chen G. Post-mortem interval effects on the phosphorylation of signaling proteins. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1017-25. PMID 12637955 DOI: 10.1038/Sj.Npp.1300112  0.615
2002 Gould TD, Chen G, Manji HK. Mood stabilizer psychopharmacology. Clinical Neuroscience Research. 2: 193-212. PMID 22707923 DOI: 10.1016/S1566-2772(02)00044-0  0.664
2002 Glitz DA, Manji HK, Moore GJ. Mood disorders: treatment-induced changes in brain neurochemistry and structure. Seminars in Clinical Neuropsychiatry. 7: 269-80. PMID 12382209 DOI: 10.1053/Scnp.2002.35226  0.437
2002 Gould TD, Manji HK. The Wnt signaling pathway in bipolar disorder. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 8: 497-511. PMID 12374432 DOI: 10.1177/107385802237176  0.675
2002 Nestler EJ, Gould E, Manji H, Buncan M, Duman RS, Greshenfeld HK, Hen R, Koester S, Lederhendler I, Meaney M, Robbins T, Winsky L, Zalcman S. Preclinical models: status of basic research in depression. Biological Psychiatry. 52: 503-28. PMID 12361666 DOI: 10.1016/S0006-3223(02)01405-1  0.481
2002 Gould TD, Manji HK. Signaling networks in the pathophysiology and treatment of mood disorders. Journal of Psychosomatic Research. 53: 687-97. PMID 12169343 DOI: 10.1016/S0022-3999(02)00426-9  0.675
2002 Coyle JT, Manji HK. Getting balance: drugs for bipolar disorder share target. Nature Medicine. 8: 557-8. PMID 12042799 DOI: 10.1038/Nm0602-557  0.435
2002 Lenox RH, Gould TD, Manji HK. Endophenotypes in bipolar disorder. American Journal of Medical Genetics. 114: 391-406. PMID 11992561 DOI: 10.1002/Ajmg.10360  0.658
2002 Manji HK, Chen G. PKC, MAP kinases and the bcl-2 family of proteins as long-term targets for mood stabilizers. Molecular Psychiatry. S46-56. PMID 11986995 DOI: 10.1038/sj.mp.4001018  0.396
2002 Manji HK, Zarate CA. Molecular and cellular mechanisms underlying mood stabilization in bipolar disorder: implications for the development of improved therapeutics. Molecular Psychiatry. S1-7. PMID 11986989 DOI: 10.1038/Sj.Mp.4001068  0.43
2002 Manji HK, Chen G. Post-receptor signaling pathways in the pathophysiology and treatment of mood disorders. Current Psychiatry Reports. 2: 479-89. PMID 11122999 DOI: 10.1007/S11920-000-0006-6  0.402
2002 Manji H, Zhou R, Chen G. Neuroplasticity and cellular resilience in bipolar disorder Bipolar Disorders. 4: 56-57. DOI: 10.1034/J.1399-5618.4.S1.21.X  0.406
2002 Manji HK, Young LT. Structural plasticity and neuronal resilience: are these targets for mood stabilizers and antidepressants in the treatment of bipolar disorder? Bipolar Disorders. 4: 77-79. DOI: 10.1034/J.1399-5618.2002.00001.X  0.424
2001 Manji HK, Moore GJ, Chen G. Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilizers. The British Journal of Psychiatry. Supplement. 41: s107-19. PMID 11450170 DOI: 10.1192/Bjp.178.41.S107  0.448
2001 Yuan PX, Huang LD, Jiang YM, Gutkind JS, Manji HK, Chen G. The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth. The Journal of Biological Chemistry. 276: 31674-83. PMID 11418608 DOI: 10.1074/Jbc.M104309200  0.348
2001 Chen G, Huang LD, Zeng WZ, Manji HK. Mood stabilizers regulate cytoprotective and mRNA-binding proteins in the brain: long-term effects on cell survival and transcript stability. The International Journal of Neuropsychopharmacology. 4: 47-64. PMID 11343630 DOI: 10.1017/S146114570100222X  0.405
2001 Manji HK, Drevets WC, Charney DS. The cellular neurobiology of depression Nature Medicine. 7: 541-547. PMID 11329053 DOI: 10.1038/87865  0.411
2001 Chen G, Masana MI, Manji HK. Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo. Bipolar Disorders. 2: 217-36. PMID 11249800 DOI: 10.1034/J.1399-5618.2000.20303.X  0.453
2001 Ikonomov OC, Petrov T, Soden K, Shisheva A, Manji HK. Lithium treatment in ovo: effects on embryonic heart rate, natural death of ciliary ganglion neurons, and brain expression of a highly conserved chicken homolog of human MTG8/ETO. Brain Research. Developmental Brain Research. 123: 13-24. PMID 11020546 DOI: 10.1016/S0165-3806(00)00074-2  0.332
2001 Manji HK, Lenox RH. Signaling: cellular insights into the pathophysiology of bipolar disorder. Biological Psychiatry. 48: 518-30. PMID 11018224 DOI: 10.1016/S0006-3223(00)00929-X  0.467
2001 Manji HK, Moore GJ, Chen G. Bipolar disorder: leads from the molecular and cellular mechanisms of action of mood stabilisers British Journal of Psychiatry. 178: s107-s119. DOI: 10.1192/BJP.178.41.S107  0.345
2000 Manji HK, Moore GJ, Rajkowska G, Chen G. Neuroplasticity and cellular resilience in mood disorders. Molecular Psychiatry. 5: 578-93. PMID 11126389 DOI: 10.1038/Sj.Mp.4000811  0.466
2000 Manji HK, Moore GJ, Chen G. Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manic-depressive illness. Biological Psychiatry. 48: 740-54. PMID 11063971 DOI: 10.1016/S0006-3223(00)00979-3  0.484
2000 Chen G, Rajkowska G, Du F, Seraji-Bozorgzad N, Manji HK. Enhancement of hippocampal neurogenesis by lithium. Journal of Neurochemistry. 75: 1729-34. PMID 10987856 DOI: 10.1046/J.1471-4159.2000.0751729.X  0.393
2000 Soares JC, Chen G, Dippold CS, Wells KF, Frank E, Kupfer DJ, Manji HK, Mallinger AG. Concurrent measures of protein kinase C and phosphoinositides in lithium-treated bipolar patients and healthy individuals: a preliminary study. Psychiatry Research-Neuroimaging. 95: 109-118. PMID 10963797 DOI: 10.1016/S0165-1781(00)00175-X  0.331
2000 Moore GJ, Bebchuk JM, Hasanat K, Chen G, Seraji-Bozorgzad N, Wilds IB, Faulk MW, Koch S, Glitz DA, Jolkovsky L, Manji HK. Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2's neurotrophic effects? Biological Psychiatry. 48: 1-8. PMID 10913502 DOI: 10.1016/S0006-3223(00)00252-3  0.353
2000 Bebchuk JM, Arfken CL, Dolan-Manji S, Murphy J, Hasanat K, Manji HK. A preliminary investigation of a protein kinase C inhibitor in the treatment of acute mania [2] Archives of General Psychiatry. 57: 95-97. PMID 10632242 DOI: 10.1001/Archpsyc.57.1.95  0.313
2000 Manji HK, McNamara R, Chen G, Lenox RH. Signalling pathways in the brain: cellular transduction of mood stabilisation in the treatment of manic-depressive illness. The Australian and New Zealand Journal of Psychiatry. S65-83. PMID 10622182 DOI: 10.1111/J.1440-1614.1999.00670.X  0.436
1999 Moore GJ, Bebchuk JM, Parrish JK, Faulk MW, Arfken CL, Strahl-Bevacqua J, Manji HK. Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness. The American Journal of Psychiatry. 156: 1902-8. PMID 10588403 DOI: 10.1176/Ajp.156.12.1902  0.42
1999 Yuan P, Chen G, Manji HK. Lithium activates the c-Jun NH2-terminal kinases in vitro and in the CNS in vivo. Journal of Neurochemistry. 73: 2299-309. PMID 10582587 DOI: 10.1046/J.1471-4159.1999.0732299.X  0.411
1999 Manji HK, Lenox RH. Ziskind-Somerfeld Research Award. Protein kinase C signaling in the brain: molecular transduction of mood stabilization in the treatment of manic-depressive illness. Biological Psychiatry. 46: 1328-51. PMID 10578449 DOI: 10.1016/S0006-3223(99)00235-8  0.433
1999 Ikonomov OC, Manji HK. Molecular mechanisms underlying mood stabilization in manic-depressive illness: the phenotype challenge. The American Journal of Psychiatry. 156: 1506-14. PMID 10518159 DOI: 10.1176/Ajp.156.10.1506  0.447
1999 Chen G, Hasanat KA, Bebchuk JM, Moore GJ, Glitz D, Manji HK. Regulation of signal transduction pathways and gene expression by mood stabilizers and antidepressants. Psychosomatic Medicine. 61: 599-617. PMID 10511011 DOI: 10.1097/00006842-199909000-00004  0.308
1999 Manji HK, Moore GJ, Chen G. Lithium at 50: have the neuroprotective effects of this unique cation been overlooked? Biological Psychiatry. 46: 929-40. PMID 10509176 DOI: 10.1016/S0006-3223(99)00165-1  0.436
1999 Chen G, Huang LD, Jiang YM, Manji HK. The mood-stabilizing agent valproate inhibits the activity of glycogen synthase kinase-3. Journal of Neurochemistry. 72: 1327-30. PMID 10037507 DOI: 10.1046/J.1471-4159.2000.0721327.X  0.348
1999 Chen G, Zeng WZ, Yuan PX, Huang LD, Jiang YM, Zhao ZH, Manji HK. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. Journal of Neurochemistry. 72: 879-82. PMID 9930766 DOI: 10.1046/J.1471-4159.1999.720879.X  0.412
1999 Chen G, Yuan PX, Jiang YM, Huang LD, Manji HK. Valproate robustly enhances AP-1 mediated gene expression. Brain Research. Molecular Brain Research. 64: 52-8. PMID 9889318 DOI: 10.1016/S0169-328X(98)00303-9  0.331
1998 Manji HK, Lenox RH. Lithium: a molecular transducer of mood-stabilization in the treatment of bipolar disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 19: 161-6. PMID 9741960 DOI: 10.1016/S0893-133X(98)00021-9  0.452
1998 Yuan PX, Chen G, Huang LD, Manji HK. Lithium stimulates gene expression through the AP-1 transcription factor pathway. Brain Research. Molecular Brain Research. 58: 225-30. PMID 9685653 DOI: 10.1016/S0169-328X(98)00114-4  0.36
1998 Chen G, Yuan PX, Jiang YM, Huang LD, Manji HK. Lithium increases tyrosine hydroxylase levels both in vivo and in vitro. Journal of Neurochemistry. 70: 1768-71. PMID 9523597 DOI: 10.1046/J.1471-4159.1998.70041768.X  0.366
1998 Moore G, Bebchuk J, Parrish J, Faulk M, Arfken C, Strhl-Bevacqua J, Manji H. 288. Monitoring of lithium induced neurochemical changes in manic depressive illness: In vivo investigation of the inositol depletion hypothesis Biological Psychiatry. 43: S86-S87. DOI: 10.1016/S0006-3223(98)90736-3  0.347
1997 Chen G, Yuan P, Hawver DB, Potter WZ, Manji HK. Increase in AP-1 transcription factor DNA binding activity by valproic acid. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 16: 238-45. PMID 9138440 DOI: 10.1016/S0893-133X(96)00239-4  0.325
1997 Mitchell PB, Manji HK, Chen G, Jolkovsky L, Smith-Jackson E, Denicoff K, Schmidt M, Potter WZ. High levels of Gs alpha in platelets of euthymic patients with bipolar affective disorder. The American Journal of Psychiatry. 154: 218-23. PMID 9016271 DOI: 10.1176/Ajp.154.2.218  0.391
1997 Ram A, Guedj F, Cravchik A, Weinstein L, Cao Q, Badner JA, Goldin LR, Grisaru N, Manji HK, Belmaker RH, Gershon ES, Gejman PV. No abnormality in the gene for the G protein stimulatory alpha subunit in patients with bipolar disorder. Archives of General Psychiatry. 54: 44-8. PMID 9006399 DOI: 10.1001/Archpsyc.1997.01830130048010  0.366
1997 Manji HK, Bersudsky Y, Chen G, Belmaker RH, Potter WZ. Modulation of protein kinase C isozymes and substrates by lithium: the role of myo-inositol. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 15: 370-81. PMID 8887991 DOI: 10.1016/0893-133X(95)00243-7  0.42
1997 Manji HK, Moore GJ, Bebchuk JM, Manji HK. Modulation of brain phosphoinositide signaling by lithium: Relationship to therapeutic response Biological Psychiatry. 42: 290S. DOI: 10.1016/S0006-3223(97)88104-8  0.311
1996 Chen G, Manji HK, Wright CB, Hawver DB, Potter WZ. Effects of valproic acid on β-adrenergic receptors, G-proteins, and adenylyl cyclase in rat C6 glioma cells Neuropsychopharmacology. 15: 271-280. PMID 8873110 DOI: 10.1016/0893-133X(95)00207-T  0.311
1996 Chen G, Pan B, Hawver DB, Wright CB, Potter WZ, Manji HK. Attenuation of cyclic AMP production by carbamazepine Journal of Neurochemistry. 67: 2079-2086. PMID 8863517 DOI: 10.1046/J.1471-4159.1996.67052079.X  0.358
1996 Stein MB, Chen G, Potter WZ, Manji HK. G-protein level quantification in platelets and leukocytes from patients with panic disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 15: 180-6. PMID 8840354 DOI: 10.1016/0893-133X(95)00182-D  0.303
1996 Mitchell P, Manji H, Chen G, Jolkovsky L, Smith-Jackson E, Denicoff K, Schmidt M, Potter W. Increased levels of Gαs in platelets of euthymic bipolar affective disorder patients European Neuropsychopharmacology. 6: 184. DOI: 10.1016/0924-977X(96)88164-8  0.378
1996 Manji HK. Regulation of transmembrane signalling systems by mood stabilizing agents: Therapeutic implications European Neuropsychopharmacology. 6: 95. DOI: 10.1016/0924-977X(96)87739-X  0.332
1995 Manji HK, Chen G, Shimon H, Hsiao JK, Potter WZ, Belmaker RH. Guanine nucleotide-binding proteins in bipolar affective disorder. Effects of long-term lithium treatment. Archives of General Psychiatry. 52: 135-44. PMID 7848049 DOI: 10.1001/Archpsyc.1995.03950140053007  0.446
1995 Manji HK, Potter WZ, Lenox RH. Signal transduction pathways. Molecular targets for lithium's actions. Archives of General Psychiatry. 52: 531-43. PMID 7598629 DOI: 10.1001/Archpsyc.1995.03950190013003  0.481
1995 Pan B, Manji HK, Schmidt ME, Potter WZ. Carbamazepine increased pregnenolone synthesis blocked by peripheral type benzodiazepine receptor antagonist Depression. 3: 267-272. DOI: 10.1002/Depr.3050030602  0.34
1994 Rudorfer MV, Manji HK, Potter WZ. Comparative tolerability profiles of the newer versus older antidepressants. Drug Safety. 10: 18-46. PMID 8136085 DOI: 10.2165/00002018-199410010-00003  0.341
1994 Manji HK, Lenox RH. Long-term action of lithium: a role for transcriptional and posttranscriptional factors regulated by protein kinase C. Synapse (New York, N.Y.). 16: 11-28. PMID 8134897 DOI: 10.1002/syn.890160103  0.348
1994 Chen G, Manji HK, Hawver DB, Wright CB, Potter WZ. Chronic sodium valproate selectively decreases protein kinase C α and ∈ in vitro Journal of Neurochemistry. 63: 2361-2364. PMID 7964759 DOI: 10.1046/J.1471-4159.1994.63062361.X  0.347
1994 Potter WZ, Manji HK. Catecholamines in depression: an update Clinical Chemistry. 40: 279-287. DOI: 10.1093/clinchem/40.2.279  0.318
1993 Manji HK, Etcheberrigaray R, Chen G, Olds JL. Lithium decreases membrane-associated protein kinase C in hippocampus: selectivity for the alpha isozyme. Journal of Neurochemistry. 61: 2303-10. PMID 8245981 DOI: 10.1111/J.1471-4159.1993.Tb07474.X  0.38
1993 Manji HK, Chen G, Bitran JA, Gusovsky F, Potter WZ. Idazoxan down-regulates beta-adrenoceptors on C6 glioma cells in vitro. European Journal of Pharmacology. 227: 275-82. PMID 1361912 DOI: 10.1016/0922-4106(92)90005-G  0.313
1991 Potter WZ, Rudorfer MV, Manji H. The pharmacologic treatment of depression. The New England Journal of Medicine. 325: 633-42. PMID 1861697 DOI: 10.1056/Nejm199108293250907  0.368
1991 Risby ED, Hsiao JK, Manji HK, Bitran J, Moses F, Zhou DF, Potter WZ. The Mechanisms of Action of Lithium: II. Effects on Adenylate Cyclase Activity and β-Adrenergic Receptor Binding in Normal Subjects Archives of General Psychiatry. 48: 513-524. PMID 1645514 DOI: 10.1001/Archpsyc.1991.01810300025004  0.35
1991 Manji HK, Hsiao JK, Risby ED, Oliver J, Rudorfer MV, Potter WZ. The mechanisms of action of lithium. I. Effects on serotoninergic and noradrenergic systems in normal subjects. Archives of General Psychiatry. 48: 505-12. PMID 1645513 DOI: 10.1001/Archpsyc.1991.01810300017003  0.315
1990 Bitran JA, Potter WZ, Manji HK, Gusovsky F. Chronic Li+ attenuates agonist- and phorbol ester-mediated Na+/H+ antiporter activity in HL-60 cells. European Journal of Pharmacology. 188: 193-202. PMID 2163872 DOI: 10.1016/0922-4106(90)90002-F  0.318
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