Husseini K. Manji - Publications

Affiliations: 
Laboratory of Molecular Pathophysiology and Experimental Therapeutics National Institute of Mental Health (NIMH) 

134 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Schloesser RJ, Orvoen S, Jimenez DV, Hardy NF, Maynard KR, Sukumar M, Manji HK, Gardier AM, David DJ, Martinowich K. Antidepressant-like Effects of Electroconvulsive Seizures Require Adult Neurogenesis in a Neuroendocrine Model of Depression. Brain Stimulation. 8: 862-7. PMID 26138027 DOI: 10.1016/j.brs.2015.05.011  0.48
2014 Svenningsson P, Berg L, Matthews D, Ionescu DF, Richards EM, Niciu MJ, Malinger A, Toups M, Manji H, Trivedi MH, Zarate CA, Greengard P. Preliminary evidence that early reduction in p11 levels in natural killer cells and monocytes predicts the likelihood of antidepressant response to chronic citalopram. Molecular Psychiatry. 19: 962-4. PMID 24614495 DOI: 10.1038/mp.2014.13  0.48
2014 Schloesser RJ, Jimenez DV, Hardy NF, Paredes D, Catlow BJ, Manji HK, McKay RD, Martinowich K. Atrophy of pyramidal neurons and increased stress-induced glutamate levels in CA3 following chronic suppression of adult neurogenesis. Brain Structure & Function. 219: 1139-48. PMID 23483239 DOI: 10.1007/s00429-013-0532-8  0.48
2014 De Sousa RT, MacHado-Vieira R, Zarate CA, Manji HK. Targeting mitochondrially mediated plasticity to develop improved therapeutics for bipolar disorder Expert Opinion On Therapeutic Targets. 18: 1131-1147. DOI: 10.1517/14728222.2014.940893  0.48
2012 Martinowich K, Cardinale KM, Schloesser RJ, Hsu M, Greig NH, Manji HK. Acetylcholinesterase inhibition ameliorates deficits in motivational drive. Behavioral and Brain Functions : Bbf. 8: 15. PMID 22433906 DOI: 10.1186/1744-9081-8-15  0.48
2012 Koss WA, Einat H, Schloesser RJ, Manji HK, Rubinow DR. Estrogen effects on the forced swim test differ in two outbred rat strains. Physiology & Behavior. 106: 81-6. PMID 22266677 DOI: 10.1016/j.physbeh.2012.01.004  0.48
2012 Schloesser RJ, Martinowich K, Manji HK. Mood-stabilizing drugs: mechanisms of action. Trends in Neurosciences. 35: 36-46. PMID 22217451 DOI: 10.1016/j.tins.2011.11.009  0.48
2012 Martinowich K, Schloesser RJ, Lu Y, Jimenez DV, Paredes D, Greene JS, Greig NH, Manji HK, Lu B. Roles of p75(NTR), long-term depression, and cholinergic transmission in anxiety and acute stress coping. Biological Psychiatry. 71: 75-83. PMID 21978521 DOI: 10.1016/j.biopsych.2011.08.014  0.48
2011 Machado-Vieira R, Pivovarova NB, Stanika RI, Yuan P, Wang Y, Zhou R, Zarate CA, Drevets WC, Brantner CA, Baum A, Laje G, McMahon FJ, Chen G, Du J, Manji HK, et al. The Bcl-2 gene polymorphism rs956572AA increases inositol 1,4,5-trisphosphate receptor-mediated endoplasmic reticulum calcium release in subjects with bipolar disorder. Biological Psychiatry. 69: 344-52. PMID 21167476 DOI: 10.1016/j.biopsych.2010.10.019  0.48
2011 Savitz JB, Nugent AC, Bogers W, Roiser JP, Bain EE, Neumeister A, Zarate CA, Manji HK, Cannon DM, Marrett S, Henn F, Charney DS, Drevets WC. Habenula volume in bipolar disorder and major depressive disorder: a high-resolution magnetic resonance imaging study. Biological Psychiatry. 69: 336-43. PMID 21094939 DOI: 10.1016/j.biopsych.2010.09.027  0.48
2011 Mah L, Zarate CA, Nugent AC, Singh JB, Manji HK, Drevets WC. Neural mechanisms of antidepressant efficacy of the dopamine receptor agonist pramipexole in treatment of bipolar depression International Journal of Neuropsychopharmacology. 14: 545-551. PMID 21029512 DOI: 10.1017/S1461145710001203  0.48
2010 Diazgranados N, Ibrahim L, Brutsche NE, Newberg A, Kronstein P, Khalife S, Kammerer WA, Quezado Z, Luckenbaugh DA, Salvadore G, Machado-Vieira R, Manji HK, Zarate CA. A randomized add-on trial of an N-methyl-D-aspartate antagonist in treatment-resistant bipolar depression Archives of General Psychiatry. 67: 793-802. PMID 20679587 DOI: 10.1001/archgenpsychiatry.2010.90  0.48
2010 Du J, Wei Y, Liu L, Wang Y, Khairova R, Blumenthal R, Tragon T, Hunsberger JG, Machado-Vieira R, Drevets W, Wang YT, Manji HK. A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. Proceedings of the National Academy of Sciences of the United States of America. 107: 11573-8. PMID 20534517 DOI: 10.1073/pnas.0913138107  0.48
2010 Salvadore G, Quiroz JA, Machado-Vieira R, Henter ID, Manji HK, Zarate CA. The neurobiology of the switch process in bipolar disorder: A review Journal of Clinical Psychiatry. 71: 1488-1501. PMID 20492846 DOI: 10.4088/JCP.09r05259gre  0.48
2010 Quiroz JA, MacHado-Vieira R, Zarate CA, Manji HK. Novel insights into lithium's mechanism of action: Neurotrophic and neuroprotective effects Neuropsychobiology. 62: 50-60. PMID 20453535 DOI: 10.1159/000314310  0.48
2010 Cornwell BR, Salvadore G, Colon-Rosario V, Latov DR, Holroyd T, Carver FW, Coppola R, Manji HK, Zarate CA, Grillon C. Abnormal hippocampal functioning and impaired spatial navigation in depressed individuals: evidence from whole-head magnetoencephalography. The American Journal of Psychiatry. 167: 836-44. PMID 20439387 DOI: 10.1176/appi.ajp.2009.09050614  0.48
2010 Sarachana T, Zhou R, Chen G, Manji HK, Hu VW. Investigation of post-transcriptional gene regulatory networks associated with autism spectrum disorders by microRNA expression profiling of lymphoblastoid cell lines. Genome Medicine. 2: 23. PMID 20374639 DOI: 10.1186/gm144  0.48
2010 Schloesser RJ, Lehmann M, Martinowich K, Manji HK, Herkenham M. Environmental enrichment requires adult neurogenesis to facilitate the recovery from psychosocial stress. Molecular Psychiatry. 15: 1152-63. PMID 20308988 DOI: 10.1038/mp.2010.34  0.48
2010 Laje G, Cannon DM, Allen AS, Klaver JM, Peck SA, Liu X, Manji HK, Drevets WC, McMahon FJ. Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 13: 715-24. PMID 20047709 DOI: 10.1017/S1461145709991027  0.48
2010 Malkesman O, Scattoni ML, Paredes D, Tragon T, Pearson B, Shaltiel G, Chen G, Crawley JN, Manji HK. The female urine sniffing test: a novel approach for assessing reward-seeking behavior in rodents. Biological Psychiatry. 67: 864-71. PMID 20034613 DOI: 10.1016/j.biopsych.2009.10.018  0.48
2010 Benninghoff J, Gritti A, Rizzi M, Lamorte G, Schloesser RJ, Schmitt A, Robel S, Genius J, Moessner R, Riederer P, Manji HK, Grunze H, Rujescu D, Moeller HJ, Lesch KP, et al. Serotonin depletion hampers survival and proliferation in neurospheres derived from adult neural stem cells. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 893-903. PMID 20010549 DOI: 10.1038/npp.2009.181  0.48
2010 Savitz J, Nugent AC, Bogers W, Liu A, Sills R, Luckenbaugh DA, Bain EE, Price JL, Zarate C, Manji HK, Cannon DM, Marrett S, Charney DS, Drevets WC. Amygdala volume in depressed patients with bipolar disorder assessed using high resolution 3T MRI: the impact of medication. Neuroimage. 49: 2966-76. PMID 19931399 DOI: 10.1016/j.neuroimage.2009.11.025  0.48
2010 Schloesser RJ, Lan M, Manji HK. Neurodegeneration in Psychiatric Illness Encyclopedia of Neuroscience. 279-283. DOI: 10.1016/B978-008045046-9.00513-1  0.48
2009 Zhou R, Holmes A, Du J, Malkesman O, Yuan P, Wang Y, Damschroder-Williams P, Chen G, Guitart X, Manji HK. Genome-wide gene expression profiling in GluR1 knockout mice: Key role of the calcium signaling pathway in glutamatergically mediated hippocampal transmission European Journal of Neuroscience. 30: 2318-2326. PMID 20092574 DOI: 10.1111/j.1460-9568.2009.07022.x  0.48
2009 Machado-Vieira R, Yuan P, Brutsche N, DiazGranados N, Luckenbaugh D, Manji HK, Zarate CA. Brain-derived neurotrophic factor and initial antidepressant response to an N-methyl-D-aspartate antagonist Journal of Clinical Psychiatry. 70: 1662-1666. PMID 19744406 DOI: 10.4088/JCP.08m04659  0.48
2009 Hunsberger JG, Austin DR, Chen G, Manji HK. Cellular mechanisms underlying affective resiliency: the role of glucocorticoid receptor- and mitochondrially-mediated plasticity. Brain Research. 1293: 76-84. PMID 19595676 DOI: 10.1016/j.brainres.2009.06.103  0.48
2009 Salvadore G, Nugent AC, Chen G, Akula N, Yuan P, Cannon DM, Zarate CA, McMahon FJ, Manji HK, Drevets WC. Bcl-2 polymorphism influences gray matter volume in the ventral striatum in healthy humans. Biological Psychiatry. 66: 804-7. PMID 19589501 DOI: 10.1016/j.biopsych.2009.05.025  0.48
2009 Zarate CA, Manji HK. Protein kinase C inhibitors: Rationale for use and potential in the treatment of bipolar disorder Cns Drugs. 23: 569-582. PMID 19552485 DOI: 10.2165/00023210-200923070-00003  0.48
2009 Machado-Vieira R, Manji HK, Zarate CA. The role of lithium in the treatment of bipolar disorder: Convergent evidence for neurotrophic effects as a unifying hypothesis Bipolar Disorders. 11: 92-109. PMID 19538689 DOI: 10.1111/j.1399-5618.2009.00714.x  0.48
2009 Creson TK, Hao Y, Engel S, Shen Y, Hamidi A, Zhuo M, Manji HK, Chen G. The anterior cingulate ERK pathway contributes to regulation of behavioral excitement and hedonic activity. Bipolar Disorders. 11: 339-50. PMID 19500087 DOI: 10.1111/j.1399-5618.2009.00697.x  0.48
2009 MacHado-Vieira R, Manji HK, Zarate CA. The role of the tripartite glutamatergic synapse in the pathophysiology and therapeutics of mood disorders Neuroscientist. 15: 525-539. PMID 19471044 DOI: 10.1177/1073858409336093  0.48
2009 Moore GJ, Cortese BM, Glitz DA, Zajac-Benitez C, Quiroz JA, Uhde TW, Drevets WC, Manji HK. A longitudinal study of the effects of lithium treatment on prefrontal and subgenual prefrontal gray matter volume in treatment-responsive bipolar disorder patients. The Journal of Clinical Psychiatry. 70: 699-705. PMID 19389332 DOI: 10.4088/JCP.07m03745  0.48
2009 Martinowich K, Schloesser RJ, Manji HK. Bipolar disorder: from genes to behavior pathways. The Journal of Clinical Investigation. 119: 726-36. PMID 19339764 DOI: 10.1172/JCI37703  0.48
2009 Schloesser RJ, Manji HK, Martinowich K. Suppression of adult neurogenesis leads to an increased hypothalamo-pituitary-adrenal axis response. Neuroreport. 20: 553-7. PMID 19322118 DOI: 10.1097/WNR.0b013e3283293e59  0.48
2009 Du J, Wang Y, Hunter R, Wei Y, Blumenthal R, Falke C, Khairova R, Zhou R, Yuan P, Machado-Vieira R, McEwen BS, Manji HK. Dynamic regulation of mitochondrial function by glucocorticoids. Proceedings of the National Academy of Sciences of the United States of America. 106: 3543-8. PMID 19202080 DOI: 10.1073/pnas.0812671106  0.48
2009 Bachmann RF, Wang Y, Yuan P, Zhou R, Li X, Alesci S, Du J, Manji HK. Common effects of lithium and valproate on mitochondrial functions: protection against methamphetamine-induced mitochondrial damage. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 12: 805-22. PMID 19149911 DOI: 10.1017/S1461145708009802  0.48
2009 Salvadore G, Cornwell BR, Colon-Rosario V, Coppola R, Grillon C, Zarate CA, Manji HK. Increased anterior cingulate cortical activity in response to fearful faces: a neurophysiological biomarker that predicts rapid antidepressant response to ketamine. Biological Psychiatry. 65: 289-95. PMID 18822408 DOI: 10.1016/j.biopsych.2008.08.014  0.48
2009 Szabo ST, Machado-Vieira R, Yuan P, Wang Y, Wei Y, Falke C, Cirelli C, Tononi G, Manji HK, Du J. Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania. Neuropharmacology. 56: 47-55. PMID 18789340 DOI: 10.1016/j.neuropharm.2008.08.015  0.48
2009 Zhou R, Yuan P, Wang Y, Hunsberger JG, Elkahloun A, Wei Y, Damschroder-Williams P, Du J, Chen G, Manji HK. Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 1395-405. PMID 18704095 DOI: 10.1038/npp.2008.131  0.48
2009 Creson TK, Yuan P, Manji HK, Chen G. Evidence for involvement of ERK, PI3K, and RSK in induction of Bcl-2 by valproate. Journal of Molecular Neuroscience : Mn. 37: 123-34. PMID 18677583 DOI: 10.1007/s12031-008-9122-2  0.48
2009 Engel SR, Creson TK, Hao Y, Shen Y, Maeng S, Nekrasova T, Landreth GE, Manji HK, Chen G. The extracellular signal-regulated kinase pathway contributes to the control of behavioral excitement Molecular Psychiatry. 14: 448-461. PMID 18227838 DOI: 10.1038/sj.mp.4002135  0.48
2008 Mallinger AG, Thase ME, Haskett R, Buttenfield J, Luckenbaugh DA, Frank E, Kupfer DJ, Manji HK. Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms. Bipolar Disorders. 10: 856-66. PMID 19594501 DOI: 10.1111/j.1399-5618.2008.00636.x  0.48
2008 Gelenberg AJ, Thase ME, Meyer RE, Goodwin FK, Katz MM, Kraemer HC, Potter WZ, Shelton RC, Fava M, Khan A, Trivedi MH, Ninan PT, Mann JJ, Bergeson S, Endicott J, ... ... Manji HK, et al. The history and current state of antidepressant clinical trial design: a call to action for proof-of-concept studies. The Journal of Clinical Psychiatry. 69: 1513-28. PMID 19192434  0.48
2008 Holmes MK, Erickson K, Luckenbaugh DA, Drevets WC, Bain EE, Cannon DM, Snow J, Sahakian BJ, Manji HK, Zarate CA. A comparison of cognitive functioning in medicated and unmedicated subjects with bipolar depression. Bipolar Disorders. 10: 806-15. PMID 19032712 DOI: 10.1111/j.1399-5618.2008.00628.x  0.48
2008 Maeng S, Hunsberger JG, Pearson B, Yuan P, Wang Y, Wei Y, McCammon J, Schloesser RJ, Zhou R, Du J, Chen G, McEwen B, Reed JC, Manji HK. BAG1 plays a critical role in regulating recovery from both manic-like and depression-like behavioral impairments. Proceedings of the National Academy of Sciences of the United States of America. 105: 8766-71. PMID 18562287 DOI: 10.1073/pnas.0803736105  0.48
2008 Sanacora G, Zarate CA, Krystal JH, Manji HK. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nature Reviews. Drug Discovery. 7: 426-37. PMID 18425072 DOI: 10.1038/nrd2462  0.48
2008 Catapano LA, Manji HK. Kinases as drug targets in the treatment of bipolar disorder. Drug Discovery Today. 13: 295-302. PMID 18405841 DOI: 10.1016/j.drudis.2008.02.007  0.48
2008 Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, et al. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biological Psychiatry. 63: 725-7. PMID 18371494 DOI: 10.1016/j.biopsych.2008.03.005  0.48
2008 Shaltiel G, Maeng S, Malkesman O, Pearson B, Schloesser RJ, Tragon T, Rogawski M, Gasior M, Luckenbaugh D, Chen G, Manji HK. Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania. Molecular Psychiatry. 13: 858-72. PMID 18332879 DOI: 10.1038/mp.2008.20  0.48
2008 Gould TD, O'Donnell KC, Picchini AM, Dow ER, Chen G, Manji HK. Generation and behavioral characterization of beta-catenin forebrain-specific conditional knock-out mice. Behavioural Brain Research. 189: 117-25. PMID 18299155 DOI: 10.1016/j.bbr.2007.12.028  0.48
2008 Quiroz JA, Gray NA, Kato T, Manji HK. Mitochondrially mediated plasticity in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2551-65. PMID 18235426 DOI: 10.1038/sj.npp.1301671  0.48
2008 Mathew SJ, Manji HK, Charney DS. Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2080-92. PMID 18172433 DOI: 10.1038/sj.npp.1301652  0.48
2008 Du J, Creson TK, Wu LJ, Ren M, Gray NA, Falke C, Wei Y, Wang Y, Blumenthal R, Machado-Vieira R, Yuan P, Chen G, Zhuo M, Manji HK. The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 68-79. PMID 18171924 DOI: 10.1523/JNEUROSCI.3080-07.2008  0.48
2008 Gould TD, O'Donnell KC, Dow ER, Du J, Chen G, Manji HK. Involvement of AMPA receptors in the antidepressant-like effects of lithium in the mouse tail suspension test and forced swim test. Neuropharmacology. 54: 577-87. PMID 18096191 DOI: 10.1016/j.neuropharm.2007.11.002  0.48
2008 Newberg AR, Catapano LA, Zarate CA, Manji HK. Neurobiology of bipolar disorder. Expert Review of Neurotherapeutics. 8: 93-110. PMID 18088203 DOI: 10.1586/14737175.8.1.93  0.48
2008 Schloesser RJ, Huang J, Klein PS, Manji HK. Cellular plasticity cascades in the pathophysiology and treatment of bipolar disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 110-33. PMID 17912251 DOI: 10.1038/sj.npp.1301575  0.48
2008 Maeng S, Zarate CA, Du J, Schloesser RJ, McCammon J, Chen G, Manji HK. Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biological Psychiatry. 63: 349-52. PMID 17643398 DOI: 10.1016/j.biopsych.2007.05.028  0.48
2008 Manji H, McEwen BS. Reply to Schmidt et al.: The long and the short of BAG1 Proceedings of the National Academy of Sciences of the United States of America. 105: E102. DOI: 10.1073/pnas.0810014105  0.48
2008 Mathew SJ, Manji HK, Charney DS. Novel drugs and therapeutic targets for severe mood disorders (Neuropsychopharmacology (2008) DOI: 10.1038/sj.npp.1301652) Neuropsychopharmacology. 33: 2300. DOI: 10.1038/npp.2008.84  0.48
2007 Laje G, Paddock S, Manji H, Rush AJ, Wilson AF, Charney D, McMahon FJ. Genetic markers of suicidal ideation emerging during citalopram treatment of major depression. The American Journal of Psychiatry. 164: 1530-8. PMID 17898344 DOI: 10.1176/appi.ajp.2007.06122018  0.48
2007 Zarate CA, Singh JB, Carlson PJ, Quiroz J, Jolkovsky L, Luckenbaugh DA, Manji HK. Efficacy of a protein kinase C inhibitor (tamoxifen) in the treatment of acute mania: a pilot study. Bipolar Disorders. 9: 561-70. PMID 17845270 DOI: 10.1111/j.1399-5618.2007.00530.x  0.48
2007 Martinowich K, Manji H, Lu B. New insights into BDNF function in depression and anxiety. Nature Neuroscience. 10: 1089-93. PMID 17726474 DOI: 10.1038/nn1971  0.48
2007 Cannon DM, Ichise M, Rollis D, Klaver JM, Gandhi SK, Charney DS, Manji HK, Drevets WC. Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder. Biological Psychiatry. 62: 870-7. PMID 17678634 DOI: 10.1016/j.biopsych.2007.03.016  0.48
2007 Paddock S, Laje G, Charney D, Rush AJ, Wilson AF, Sorant AJ, Lipsky R, Wisniewski SR, Manji H, McMahon FJ. Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort. The American Journal of Psychiatry. 164: 1181-8. PMID 17671280 DOI: 10.1176/appi.ajp.2007.06111790  0.48
2007 Einat H, Yuan P, Szabo ST, Dogra S, Manji HK. Protein kinase C inhibition by tamoxifen antagonizes manic-like behavior in rats: implications for the development of novel therapeutics for bipolar disorder. Neuropsychobiology. 55: 123-31. PMID 17641532 DOI: 10.1159/000106054  0.48
2007 Hu XZ, Rush AJ, Charney D, Wilson AF, Sorant AJ, Papanicolaou GJ, Fava M, Trivedi MH, Wisniewski SR, Laje G, Paddock S, McMahon FJ, Manji H, Lipsky RH. Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression. Archives of General Psychiatry. 64: 783-92. PMID 17606812 DOI: 10.1001/archpsyc.64.7.783  0.48
2007 Chuang DM, Manji HK. In search of the Holy Grail for the treatment of neurodegenerative disorders: has a simple cation been overlooked? Biological Psychiatry. 62: 4-6. PMID 17572175 DOI: 10.1016/j.biopsych.2007.04.008  0.48
2007 Gould TD, Dow ER, O'Donnell KC, Chen G, Manji HK. Targeting signal transduction pathways in the treatment of mood disorders: recent insights into the relevance of the Wnt pathway. Cns & Neurological Disorders Drug Targets. 6: 193-204. PMID 17511616 DOI: 10.2174/187152707780619308  0.48
2007 Agid Y, Buzsáki G, Diamond DM, Frackowiak R, Giedd J, Girault JA, Grace A, Lambert JJ, Manji H, Mayberg H, Popoli M, Prochiantz A, Richter-Levin G, Somogyi P, Spedding M, et al. How can drug discovery for psychiatric disorders be improved? Nature Reviews. Drug Discovery. 6: 189-201. PMID 17330070 DOI: 10.1038/nrd2217  0.48
2007 Gould NF, Holmes MK, Fantie BD, Luckenbaugh DA, Pine DS, Gould TD, Burgess N, Manji HK, Zarate CA. Performance on a virtual reality spatial memory navigation task in depressed patients. The American Journal of Psychiatry. 164: 516-9. PMID 17329478 DOI: 10.1176/ajp.2007.164.3.516  0.48
2007 Gould TD, Einat H, O'Donnell KC, Picchini AM, Schloesser RJ, Manji HK. Beta-catenin overexpression in the mouse brain phenocopies lithium-sensitive behaviors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 2173-83. PMID 17299510 DOI: 10.1038/sj.npp.1301338  0.48
2007 Schloesser RJ, Chen G, Manji HK. Neurogenesis and neuroenhancement in the pathophysiology and treatment of bipolar disorder. International Review of Neurobiology. 77: 143-78. PMID 17178474 DOI: 10.1016/S0074-7742(06)77005-2  0.48
2007 Gould TD, O'Donnell KC, Picchini AM, Manji HK. Strain differences in lithium attenuation of d-amphetamine-induced hyperlocomotion: a mouse model for the genetics of clinical response to lithium. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 1321-33. PMID 17151598 DOI: 10.1038/sj.npp.1301254  0.48
2007 Catapano LA, Manji HK. G protein-coupled receptors in major psychiatric disorders. Biochimica Et Biophysica Acta. 1768: 976-93. PMID 17078926 DOI: 10.1016/j.bbamem.2006.09.025  0.48
2006 Du J, Machado-Vieira R, Maeng S, Martinowich K, Manji HK, Zarate CA. Enhancing AMPA to NMDA throughput as a convergent mechanism for antidepressant action. Drug Discovery Today. Therapeutic Strategies. 3: 519-526. PMID 25411578 DOI: 10.1016/j.ddstr.2006.11.012  0.48
2006 Gould TD, Picchini AM, Einat H, Manji HK. Targeting glycogen synthase kinase-3 in the CNS: implications for the development of new treatments for mood disorders. Current Drug Targets. 7: 1399-409. PMID 17100580  0.48
2006 Miller AH, Manji HK. On redefining the role of the immune system in psychiatric disease. Biological Psychiatry. 60: 796-8. PMID 17045861 DOI: 10.1016/j.biopsych.2006.09.013  0.48
2006 Zarate CA, Singh JB, Carlson PJ, Brutsche NE, Ameli R, Luckenbaugh DA, Charney DS, Manji HK. A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Archives of General Psychiatry. 63: 856-64. PMID 16894061 DOI: 10.1001/archpsyc.63.8.856  0.48
2006 McMahon FJ, Buervenich S, Charney D, Lipsky R, Rush AJ, Wilson AF, Sorant AJ, Papanicolaou GJ, Laje G, Fava M, Trivedi MH, Wisniewski SR, Manji H. Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. American Journal of Human Genetics. 78: 804-14. PMID 16642436 DOI: 10.1086/503820  0.48
2006 Hasler G, Drevets WC, Gould TD, Gottesman II, Manji HK. Toward constructing an endophenotype strategy for bipolar disorders. Biological Psychiatry. 60: 93-105. PMID 16406007 DOI: 10.1016/j.biopsych.2005.11.006  0.48
2005 Bachmann RF, Schloesser RJ, Gould TD, Manji HK. Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics. Molecular Neurobiology. 32: 173-202. PMID 16215281 DOI: 10.1385/MN:32:2:173  0.48
2005 Zhou R, Gray NA, Yuan P, Li X, Chen J, Chen G, Damschroder-Williams P, Du J, Zhang L, Manji HK. The anti-apoptotic, glucocorticoid receptor cochaperone protein BAG-1 is a long-term target for the actions of mood stabilizers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4493-502. PMID 15872096 DOI: 10.1523/JNEUROSCI.4530-04.2005  0.48
2005 Neumeister A, Charney DS, Belfer I, Geraci M, Holmes C, Sharabi Y, Alim T, Bonne O, Luckenbaugh DA, Manji H, Goldman D, Goldstein DS. Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans. Pharmacogenetics and Genomics. 15: 143-9. PMID 15861038  0.48
2005 Gould TD, Manji HK. Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 1223-37. PMID 15827567 DOI: 10.1038/sj.npp.1300731  0.48
2005 Neumeister A, Yuan P, Young TA, Bonne O, Luckenbaugh DA, Charney DS, Manji H. Effects of tryptophan depletion on serum levels of brain-derived neurotrophic factor in unmedicated patients with remitted depression and healthy subjects. The American Journal of Psychiatry. 162: 805-7. PMID 15800160 DOI: 10.1176/appi.ajp.162.4.805  0.48
2005 Gould TD, Manji HK. DARPP-32: A molecular switch at the nexus of reward pathway plasticity. Proceedings of the National Academy of Sciences of the United States of America. 102: 253-4. PMID 15632217 DOI: 10.1073/pnas.0408700102  0.48
2005 Yuan PX, Zhou R, Farzad N, Gould TD, Gray NA, Du J, Manji HK. Chapter 5.7 Enhancing resilience to stress: the role of signaling cascades Techniques in the Behavioral and Neural Sciences. 15: 751-771. DOI: 10.1016/S0921-0709(05)80040-9  0.48
2005 Zarate CA, Singh JB, Carlson PJ, Manji HK. Molecular mechanisms of bipolar disorder Drug Discovery Today: Disease Mechanisms. 2: 435-445. DOI: 10.1016/j.ddmec.2005.11.005  0.48
2004 Birnbaum SG, Yuan PX, Wang M, Vijayraghavan S, Bloom AK, Davis DJ, Gobeske KT, Sweatt JD, Manji HK, Arnsten AF. Protein kinase C overactivity impairs prefrontal cortical regulation of working memory. Science (New York, N.Y.). 306: 882-4. PMID 15514161 DOI: 10.1126/science.1100021  0.48
2004 Quiroz JA, Gould TD, Manji HK. Molecular effects of lithium. Molecular Interventions. 4: 259-72. PMID 15471909 DOI: 10.1124/mi.4.5.6  0.48
2004 Gould TD, Einat H, Bhat R, Manji HK. AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. The International Journal of Neuropsychopharmacology. 7: 387-90. PMID 15315719 DOI: 10.1017/S1461145704004535  0.48
2004 Hao Y, Creson T, Zhang L, Li P, Du F, Yuan P, Gould TD, Manji HK, Chen G. Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6590-9. PMID 15269271 DOI: 10.1523/JNEUROSCI.5747-03.2004  0.48
2004 Du J, Gray NA, Falke CA, Chen W, Yuan P, Szabo ST, Einat H, Manji HK. Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6578-89. PMID 15269270 DOI: 10.1523/JNEUROSCI.1258-04.2004  0.48
2004 Gould TD, Manji HK. The molecular medicine revolution and psychiatry: bridging the gap between basic neuroscience research and clinical psychiatry. The Journal of Clinical Psychiatry. 65: 598-604. PMID 15163244  0.48
2004 Du J, Szabo ST, Gray NA, Manji HK. Focus on CaMKII: a molecular switch in the pathophysiology and treatment of mood and anxiety disorders. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 7: 243-8. PMID 15154976 DOI: 10.1017/S1461145704004432  0.48
2004 Charney DS, Manji HK. Life stress, genes, and depression: multiple pathways lead to increased risk and new opportunities for intervention Science's Stke : Signal Transduction Knowledge Environment. 2004. PMID 15039492  0.48
2004 Gould TD, Zarate CA, Manji HK. Glycogen synthase kinase-3: a target for novel bipolar disorder treatments. The Journal of Clinical Psychiatry. 65: 10-21. PMID 14744163  0.48
2004 Gould TD, Chen G, Manji HK. In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 32-8. PMID 12942141 DOI: 10.1038/sj.npp.1300283  0.48
2004 Yuan P, Gould TD, Gray NA, Bachmann RF, Schloesser RJ, Lan MJK, Du J, Moore GJ, Manji HK. Neurotrophic signaling cascades are major long-term targets for lithium: Clinical implications Clinical Neuroscience Research. 4: 137-153. DOI: 10.1016/j.cnr.2004.09.006  0.48
2003 Gray NA, Du J, Falke CS, Yuan P, Manji HK. Lithium regulates total and synaptic expression of the AMPA glutamate receptor GluR2 in vitro and in vivo. Annals of the New York Academy of Sciences. 1003: 402-4. PMID 14684472 DOI: 10.1196/annals.1300.036  0.48
2003 Du J, Gray NA, Falke C, Yuan P, Szabo S, Manji HK. Structurally dissimilar antimanic agents modulate synaptic plasticity by regulating AMPA glutamate receptor subunit GluR1 synaptic expression. Annals of the New York Academy of Sciences. 1003: 378-80. PMID 14684466 DOI: 10.1196/annals.1300.031  0.48
2003 Zarate CA, Du J, Quiroz J, Gray NA, Denicoff KD, Singh J, Charney DS, Manji HK. Regulation of cellular plasticity cascades in the pathophysiology and treatment of mood disorders: role of the glutamatergic system. Annals of the New York Academy of Sciences. 1003: 273-91. PMID 14684452 DOI: 10.1196/annals.1300.017  0.48
2003 Manji HK, Gottesman II, Gould TD. Signal transduction and genes-to-behaviors pathways in psychiatric diseases. Science's Stke : Signal Transduction Knowledge Environment. 2003: pe49. PMID 14600293 DOI: 10.1126/stke.2003.207.pe49  0.48
2003 Ketter TA, Manji HK, Post RM. Potential mechanisms of action of lamotrigine in the treatment of bipolar disorders. Journal of Clinical Psychopharmacology. 23: 484-95. PMID 14520126 DOI: 10.1097/01.jcp.0000088915.02635.e8  0.48
2003 Einat H, Yuan P, Gould TD, Li J, Du J, Zhang L, Manji HK, Chen G. The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7311-6. PMID 12917364  0.48
2003 Dick DM, Foroud T, Flury L, Bowman ES, Miller MJ, Rau NL, Moe PR, Samavedy N, El-Mallakh R, Manji H, Glitz DA, Meyer ET, Smiley C, Hahn R, Widmark C, et al. Genomewide linkage analyses of bipolar disorder: a new sample of 250 pedigrees from the National Institute of Mental Health Genetics Initiative. American Journal of Human Genetics. 73: 107-14. PMID 12772088 DOI: 10.1086/376562  0.48
2003 Gould TD, Gray NA, Manji HK. Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice. Pharmacological Research. 48: 49-53. PMID 12770514 DOI: 10.1016/S1043-6618(03)00096-3  0.48
2003 Manji HK, Quiroz JA, Sporn J, Payne JL, Denicoff K, A Gray N, Zarate CA, Charney DS. Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression. Biological Psychiatry. 53: 707-42. PMID 12706957 DOI: 10.1016/S0006-3223(03)00117-3  0.48
2003 Li J, Gould TD, Yuan P, Manji HK, Chen G. Post-mortem interval effects on the phosphorylation of signaling proteins. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: 1017-25. PMID 12637955 DOI: 10.1038/sj.npp.1300112  0.48
2003 Huang X, Wu DY, Chen G, Manji H, Chen DF. Support of retinal ganglion cell survival and axon regeneration by lithium through a Bcl-2-dependent mechanism Investigative Ophthalmology and Visual Science. 44: 347-354. PMID 12506095 DOI: 10.1167/iovs.02-0198  0.48
2002 Gould TD, Chen G, Manji HK. Mood stabilizer psychopharmacology. Clinical Neuroscience Research. 2: 193-212. PMID 22707923 DOI: 10.1016/S1566-2772(02)00044-0  0.48
2002 Payne JL, Quiroz JA, Zarate CA, Manji HK. Timing is everything: does the robust upregulation of noradrenergically regulated plasticity genes underlie the rapid antidepressant effects of sleep deprivation? Biological Psychiatry. 52: 921-6. PMID 12437933 DOI: 10.1016/S0006-3223(02)01676-1  0.48
2002 Glitz DA, Manji HK, Moore GJ. Mood disorders: treatment-induced changes in brain neurochemistry and structure. Seminars in Clinical Neuropsychiatry. 7: 269-80. PMID 12382209 DOI: 10.1053/SCNP.2002.35226  0.48
2002 Gould TD, Manji HK. The Wnt signaling pathway in bipolar disorder. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 8: 497-511. PMID 12374432 DOI: 10.1177/107385802237176  0.48
2002 Nestler EJ, Gould E, Manji H, Buncan M, Duman RS, Greshenfeld HK, Hen R, Koester S, Lederhendler I, Meaney M, Robbins T, Winsky L, Zalcman S. Preclinical models: status of basic research in depression. Biological Psychiatry. 52: 503-28. PMID 12361666 DOI: 10.1016/S0006-3223(02)01405-1  0.48
2002 Gould TD, Manji HK. Signaling networks in the pathophysiology and treatment of mood disorders. Journal of Psychosomatic Research. 53: 687-97. PMID 12169343  0.48
2002 Coyle JT, Manji HK. Getting balance: drugs for bipolar disorder share target. Nature Medicine. 8: 557-8. PMID 12042799 DOI: 10.1038/nm0602-557  0.48
2002 Lenox RH, Gould TD, Manji HK. Endophenotypes in bipolar disorder. American Journal of Medical Genetics. 114: 391-406. PMID 11992561 DOI: 10.1002/ajmg.10360  0.48
2001 Manji HK, Drevets WC, Charney DS. The cellular neurobiology of depression Nature Medicine. 7: 541-547. PMID 11329053 DOI: 10.1038/87865  0.48
2000 Manji HK, Moore GJ, Rajkowska G, Chen G. Neuroplasticity and cellular resilience in mood disorders. Molecular Psychiatry. 5: 578-93. PMID 11126389 DOI: 10.1038/sj.mp.4000811  0.48
2000 Manji HK, Moore GJ, Chen G. Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manic-depressive illness. Biological Psychiatry. 48: 740-54. PMID 11063971 DOI: 10.1016/S0006-3223(00)00979-3  0.48
2000 Chen G, Rajkowska G, Du F, Seraji-Bozorgzad N, Manji HK. Enhancement of hippocampal neurogenesis by lithium. Journal of Neurochemistry. 75: 1729-34. PMID 10987856 DOI: 10.1046/j.1471-4159.2000.0751729.x  0.48
2000 Moore GJ, Bebchuk JM, Hasanat K, Chen G, Seraji-Bozorgzad N, Wilds IB, Faulk MW, Koch S, Glitz DA, Jolkovsky L, Manji HK. Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2's neurotrophic effects? Biological Psychiatry. 48: 1-8. PMID 10913502 DOI: 10.1016/S0006-3223(00)00252-3  0.48
1999 Moore GJ, Bebchuk JM, Parrish JK, Faulk MW, Arfken CL, Strahl-Bevacqua J, Manji HK. Temporal dissociation between lithium-induced changes in frontal lobe myo-inositol and clinical response in manic-depressive illness. The American Journal of Psychiatry. 156: 1902-8. PMID 10588403 DOI: 10.1176/AJP.156.12.1902  0.48
1999 Chen G, Hasanat KA, Bebchuk JM, Moore GJ, Glitz D, Manji HK. Regulation of signal transduction pathways and gene expression by mood stabilizers and antidepressants. Psychosomatic Medicine. 61: 599-617. PMID 10511011 DOI: 10.1097/00006842-199909000-00004  0.48
1999 Manji HK, Moore GJ, Chen G. Lithium at 50: have the neuroprotective effects of this unique cation been overlooked? Biological Psychiatry. 46: 929-40. PMID 10509176 DOI: 10.1016/S0006-3223(99)00165-1  0.48
1997 Ram A, Guedj F, Cravchik A, Weinstein L, Cao Q, Badner JA, Goldin LR, Grisaru N, Manji HK, Belmaker RH, Gershon ES, Gejman PV. No abnormality in the gene for the G protein stimulatory alpha subunit in patients with bipolar disorder. Archives of General Psychiatry. 54: 44-8. PMID 9006399 DOI: 10.1001/archpsyc.1997.01830130048010  0.48
1996 Chen G, Manji HK, Wright CB, Hawver DB, Potter WZ. Effects of valproic acid on β-adrenergic receptors, G-proteins, and adenylyl cyclase in rat C6 glioma cells Neuropsychopharmacology. 15: 271-280. PMID 8873110 DOI: 10.1016/0893-133X(95)00207-T  0.48
1996 Chen G, Pan B, Hawver DB, Wright CB, Potter WZ, Manji HK. Attenuation of cyclic AMP production by carbamazepine Journal of Neurochemistry. 67: 2079-2086. PMID 8863517  0.48
1994 Suyama K, Dykstra KH, Masana MI, Manji HK, Potter WZ. In vivo evidence that nonneuronal β-adrenoceptors as well as dopamine receptors contribute to cyclic AMP efflux in rat striatum Journal of Neurochemistry. 62: 1734-1740. PMID 8158123 DOI: 10.1046/J.1471-4159.1994.62051734.X  0.48
1994 Chen G, Manji HK, Hawver DB, Wright CB, Potter WZ. Chronic sodium valproate selectively decreases protein kinase C α and ∈ in vitro Journal of Neurochemistry. 63: 2361-2364. PMID 7964759  0.48
1993 Manji HK, Etcheberrigaray R, Chen G, Olds JL. Lithium decreases membrane-associated protein kinase C in hippocampus: selectivity for the alpha isozyme. Journal of Neurochemistry. 61: 2303-10. PMID 8245981 DOI: 10.1111/j.1471-4159.1993.tb07474.x  0.48
1992 Potter WZ, Manji HK, Dawkins K, Grossman F. Combined measures of noradrenergic output and receptor responsivity in depression Clinical Neuropharmacology. 15. PMID 1498854 DOI: 10.1097/00002826-199201001-00165  0.48
1991 Risby ED, Hsiao JK, Manji HK, Bitran J, Moses F, Zhou DF, Potter WZ. The Mechanisms of Action of Lithium: II. Effects on Adenylate Cyclase Activity and β-Adrenergic Receptor Binding in Normal Subjects Archives of General Psychiatry. 48: 513-524. PMID 1645514 DOI: 10.1001/archpsyc.1991.01810300025004  0.48
Show low-probability matches.