Robyn S. Klein, M.D. Ph.D. - Publications

Affiliations: 
Infectious Diseases Washington University School of Medicine, St. Louis, MO, United States 
Area:
Neuroimmunology

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Klein RS, Voskuhl R, Segal BM, Dittel BN, Lane TE, Bethea JR, Carson MJ, Colton C, Rosi S, Anderson A, Piccio L, Goverman JM, Benveniste EN, Brown MA, Tiwari-Woodruff SK, et al. Speaking out about gender imbalance in invited speakers improves diversity. Nature Immunology. 18: 475-478. PMID 28418385 DOI: 10.1038/ni.3707  1
2016 Vasek MJ, Garber C, Dorsey D, Durrant DM, Bollman B, Soung A, Yu J, Perez-Torres C, Frouin A, Wilton DK, Funk K, DeMasters BK, Jiang X, Bowen JR, Mennerick S, ... ... Klein RS, et al. A complement-microglial axis drives synapse loss during virus-induced memory impairment. Nature. 534: 538-543. PMID 27337340 DOI: 10.1038/nature18283  1
2016 Pal P, Daniels BP, Oskman A, Diamond MS, Klein RS, Goldberg DE. Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis. Mbio. 7. PMID 27273825 DOI: 10.1128/mBio.00617-16  1
2016 Salimi H, Cain MD, Klein RS. Encephalitic Arboviruses: Emergence, Clinical Presentation, and Neuropathogenesis. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 27220616 DOI: 10.1007/s13311-016-0443-5  1
2016 Miner JJ, Cao B, Govero J, Smith AM, Fernandez E, Cabrera OH, Garber C, Noll M, Klein RS, Noguchi KK, Mysorekar IU, Diamond MS. Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise. Cell. PMID 27180225 DOI: 10.1016/j.cell.2016.05.008  1
2016 Hou J, Baker LA, Zhou L, Klein RS. Viral interactions with the blood-brain barrier: old dog, new tricks. Tissue Barriers. 4: e1142492. PMID 27141421 DOI: 10.1080/21688370.2016.1142492  1
2016 Durrant DM, Ghosh S, Klein RS. The Olfactory Bulb: An Immunosensory Effector Organ during Neurotropic Viral Infections. Acs Chemical Neuroscience. PMID 27058872 DOI: 10.1021/acschemneuro.6b00043  1
2015 Durrant DM, Daniels BP, Pasieka T, Dorsey D, Klein RS. CCR5 limits cortical viral loads during West Nile virus infection of the central nervous system. Journal of Neuroinflammation. 12: 233. PMID 26667390 DOI: 10.1186/s12974-015-0447-9  1
2015 Miner JJ, Daniels BP, Shrestha B, Proenca-Modena JL, Lew ED, Lazear HM, Gorman MJ, Lemke G, Klein RS, Diamond MS. The TAM receptor Mertk protects against neuroinvasive viral infection by maintaining blood-brain barrier integrity. Nature Medicine. PMID 26523970 DOI: 10.1038/nm.3974  1
2015 Daniels BP, Klein RS. Knocking on Closed Doors: Host Interferons Dynamically Regulate Blood-Brain Barrier Function during Viral Infections of the Central Nervous System. Plos Pathogens. 11: e1005096. PMID 26379171 DOI: 10.1371/journal.ppat.1005096  1
2015 Yue X, Jin H, Liu H, Rosenberg AJ, Klein RS, Tu Z. A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression. Organic & Biomolecular Chemistry. 13: 7928-39. PMID 26108234 DOI: 10.1039/c5ob00951k  1
2015 Lazear HM, Daniels BP, Pinto AK, Huang AC, Vick SC, Doyle SE, Gale M, Klein RS, Diamond MS. Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier. Science Translational Medicine. 7: 284ra59. PMID 25904743 DOI: 10.1126/scitranslmed.aaa4304  1
2015 Daniels BP, Klein RS. Viral sensing at the blood-brain barrier: new roles for innate immunity at the CNS vasculature. Clinical Pharmacology and Therapeutics. 97: 372-9. PMID 25670037 DOI: 10.1002/cpt.75  1
2015 Cantoni C, Bollman B, Licastro D, Xie M, Mikesell R, Schmidt R, Yuede CM, Galimberti D, Olivecrona G, Klein RS, Cross AH, Otero K, Piccio L. TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta Neuropathologica. 129: 429-47. PMID 25631124 DOI: 10.1007/s00401-015-1388-1  1
2014 Durrant DM, Daniels BP, Klein RS. IL-1R1 signaling regulates CXCL12-mediated T cell localization and fate within the central nervous system during West Nile Virus encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 193: 4095-106. PMID 25200953 DOI: 10.4049/jimmunol.1401192  1
2014 Daniels BP, Holman DW, Cruz-Orengo L, Jujjavarapu H, Durrant DM, Klein RS. Viral pathogen-associated molecular patterns regulate blood-brain barrier integrity via competing innate cytokine signals. Mbio. 5: e01476-14. PMID 25161189 DOI: 10.1128/mBio.01476-14  1
2014 Williams JL, Holman DW, Klein RS. Chemokines in the balance: maintenance of homeostasis and protection at CNS barriers. Frontiers in Cellular Neuroscience. 8: 154. PMID 24920943 DOI: 10.3389/fncel.2014.00154  1
2014 Cruz-Orengo L, Daniels BP, Dorsey D, Basak SA, Grajales-Reyes JG, McCandless EE, Piccio L, Schmidt RE, Cross AH, Crosby SD, Klein RS. Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility. The Journal of Clinical Investigation. 124: 2571-84. PMID 24812668 DOI: 10.1172/JCI73408  1
2014 Sun T, Vasek MJ, Klein RS. Congenitally acquired persistent lymphocytic choriomeningitis viral infection reduces neuronal progenitor pools in the adult hippocampus and subventricular zone. Plos One. 9: e96442. PMID 24802239 DOI: 10.1371/journal.pone.0096442  1
2014 Williams JL, Patel JR, Daniels BP, Klein RS. Targeting CXCR7/ACKR3 as a therapeutic strategy to promote remyelination in the adult central nervous system. The Journal of Experimental Medicine. 211: 791-9. PMID 24733828 DOI: 10.1084/jem.20131224  1
2014 Reddy AS, Patel JR, Vogler C, Klein RS, Sands MS. Central nervous system pathology progresses independently of KC and CXCR2 in globoid-cell leukodystrophy. Plos One. 8: e64647. PMID 23755134 DOI: 10.1371/journal.pone.0064647  1
2013 Cross AH, Klein RS. Comment: assessing humoral immunocompetence after alemtuzumab treatment in MS. Neurology. 81: 875. PMID 23925764 DOI: 10.1212/WNL.0b013e3182a352c6  1
2013 Durrant DM, Robinette ML, Klein RS. IL-1R1 is required for dendritic cell-mediated T cell reactivation within the CNS during West Nile virus encephalitis. The Journal of Experimental Medicine. 210: 503-16. PMID 23460727 DOI: 10.1084/jem.20121897  1
2013 Daniels BP, Cruz-Orengo L, Pasieka TJ, Couraud PO, Romero IA, Weksler B, Cooper JA, Doering TL, Klein RS. Immortalized human cerebral microvascular endothelial cells maintain the properties of primary cells in an in vitro model of immune migration across the blood brain barrier. Journal of Neuroscience Methods. 212: 173-9. PMID 23068604 DOI: 10.1016/j.jneumeth.2012.10.001  1
2012 Cross AH, Klein RS, Piccio L. Rituximab combination therapy in relapsing multiple sclerosis. Therapeutic Advances in Neurological Disorders. 5: 311-9. PMID 23139702 DOI: 10.1177/1756285612461165  1
2012 Patel JR, Williams JL, Muccigrosso MM, Liu L, Sun T, Rubin JB, Klein RS. Astrocyte TNFR2 is required for CXCL12-mediated regulation of oligodendrocyte progenitor proliferation and differentiation within the adult CNS. Acta Neuropathologica. 124: 847-60. PMID 22933014 DOI: 10.1007/s00401-012-1034-0  1
2011 Wang Y, Wang Q, Haldar JP, Yeh FC, Xie M, Sun P, Tu TW, Trinkaus K, Klein RS, Cross AH, Song SK. Quantification of increased cellularity during inflammatory demyelination. Brain : a Journal of Neurology. 134: 3590-601. PMID 22171354 DOI: 10.1093/brain/awr307  1
2011 Cruz-Orengo L, Chen YJ, Kim JH, Dorsey D, Song SK, Klein RS. CXCR7 antagonism prevents axonal injury during experimental autoimmune encephalomyelitis as revealed by in vivo axial diffusivity. Journal of Neuroinflammation. 8: 170. PMID 22145790 DOI: 10.1186/1742-2094-8-170  1
2011 Reddy AS, Kim JH, Hawkins-Salsbury JA, Macauley SL, Tracy ET, Vogler CA, Han X, Song SK, Wozniak DF, Fowler SC, Klein RS, Sands MS. Bone marrow transplantation augments the effect of brain- and spinal cord-directed adeno-associated virus 2/5 gene therapy by altering inflammation in the murine model of globoid-cell leukodystrophy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9945-57. PMID 21734286 DOI: 10.1523/JNEUROSCI.1802-11.2011  1
2011 Patel JR, Klein RS. Mediators of oligodendrocyte differentiation during remyelination. Febs Letters. 585: 3730-7. PMID 21539842 DOI: 10.1016/j.febslet.2011.04.037  1
2011 Cruz-Orengo L, Holman DW, Dorsey D, Zhou L, Zhang P, Wright M, McCandless EE, Patel JR, Luker GD, Littman DR, Russell JH, Klein RS. CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity. The Journal of Experimental Medicine. 208: 327-39. PMID 21300915 DOI: 10.1084/jem.20102010  1
2011 Holman DW, Klein RS, Ransohoff RM. The blood-brain barrier, chemokines and multiple sclerosis. Biochimica Et Biophysica Acta. 1812: 220-30. PMID 20692338 DOI: 10.1016/j.bbadis.2010.07.019  1
2010 Zhang B, Patel J, Croyle M, Diamond MS, Klein RS. TNF-alpha-dependent regulation of CXCR3 expression modulates neuronal survival during West Nile virus encephalitis. Journal of Neuroimmunology. 224: 28-38. PMID 20579746 DOI: 10.1016/j.jneuroim.2010.05.003  1
2010 Piccio L, Naismith RT, Trinkaus K, Klein RS, Parks BJ, Lyons JA, Cross AH. Changes in B- and T-lymphocyte and chemokine levels with rituximab treatment in multiple sclerosis. Archives of Neurology. 67: 707-14. PMID 20558389 DOI: 10.1001/archneurol.2010.99  1
2010 Patel JR, McCandless EE, Dorsey D, Klein RS. CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination. Proceedings of the National Academy of Sciences of the United States of America. 107: 11062-7. PMID 20534485 DOI: 10.1073/pnas.1006301107  1
2010 Klein RS, McCandless EE. HIV coreceptors and their roles in leukocyte trafficking during neuroinflammatory diseases Chemokine Receptors and Neuroaids: Beyond Co-Receptor Function and Links to Other Neuropathologies. 119-146. DOI: 10.1007/978-1-4419-0793-6_6  1
2009 McCandless EE, Budde M, Lees JR, Dorsey D, Lyng E, Klein RS. IL-1R signaling within the central nervous system regulates CXCL12 expression at the blood-brain barrier and disease severity during experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 183: 613-20. PMID 19535637 DOI: 10.4049/jimmunol.0802258  1
2008 McCandless EE, Zhang B, Diamond MS, Klein RS. CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis. Proceedings of the National Academy of Sciences of the United States of America. 105: 11270-5. PMID 18678898 DOI: 10.1073/pnas.0800898105  1
2008 Shrestha B, Zhang B, Purtha WE, Klein RS, Diamond MS. Tumor necrosis factor alpha protects against lethal West Nile virus infection by promoting trafficking of mononuclear leukocytes into the central nervous system. Journal of Virology. 82: 8956-64. PMID 18632856 DOI: 10.1128/JVI.01118-08  1
2008 Klein RS, Diamond MS. Immunological headgear: antiviral immune responses protect against neuroinvasive West Nile virus. Trends in Molecular Medicine. 14: 286-94. PMID 18539532 DOI: 10.1016/j.molmed.2008.05.004  1
2008 McCandless EE, Piccio L, Woerner BM, Schmidt RE, Rubin JB, Cross AH, Klein RS. Pathological expression of CXCL12 at the blood-brain barrier correlates with severity of multiple sclerosis. The American Journal of Pathology. 172: 799-808. PMID 18276777 DOI: 10.2353/ajpath.2008.070918  1
2008 Zhang B, Chan YK, Lu B, Diamond MS, Klein RS. CXCR3 mediates region-specific antiviral T cell trafficking within the central nervous system during West Nile virus encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 180: 2641-9. PMID 18250476  1
2008 Klein RS. A moving target: the multiple roles of CCR5 in infectious diseases. The Journal of Infectious Diseases. 197: 183-6. PMID 18179384 DOI: 10.1086/524692  1
2007 McCandless EE, Klein RS. Molecular targets for disrupting leukocyte trafficking during multiple sclerosis. Expert Reviews in Molecular Medicine. 9: 1-19. PMID 17637110 DOI: 10.1017/S1462399407000397  1
2007 Sitati E, McCandless EE, Klein RS, Diamond MS. CD40-CD40 ligand interactions promote trafficking of CD8+ T cells into the brain and protection against West Nile virus encephalitis. Journal of Virology. 81: 9801-11. PMID 17626103 DOI: 10.1128/JVI.00941-07  1
2006 McCandless EE, Wang Q, Woerner BM, Harper JM, Klein RS. CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 177: 8053-64. PMID 17114479  1
2006 Archambault AS, Sim J, McCandless EE, Klein RS, Russell JH. Region-specific regulation of inflammation and pathogenesis in experimental autoimmune encephalomyelitis. Journal of Neuroimmunology. 181: 122-32. PMID 17030428 DOI: 10.1016/j.jneuroim.2006.08.012  1
2006 Diamond MS, Klein RS. A genetic basis for human susceptibility to West Nile virus. Trends in Microbiology. 14: 287-9. PMID 16750369 DOI: 10.1016/j.tim.2006.05.004  1
2006 Gimenez MA, Sim J, Archambault AS, Klein RS, Russell JH. A tumor necrosis factor receptor 1-dependent conversation between central nervous system-specific T cells and the central nervous system is required for inflammatory infiltration of the spinal cord. The American Journal of Pathology. 168: 1200-9. PMID 16565495 DOI: 10.2353/ajpath.2006.050332  1
2006 Kim JH, Budde MD, Liang HF, Klein RS, Russell JH, Cross AH, Song SK. Detecting axon damage in spinal cord from a mouse model of multiple sclerosis. Neurobiology of Disease. 21: 626-32. PMID 16298135 DOI: 10.1016/j.nbd.2005.09.009  1
2005 Klein RS, Lin E, Zhang B, Luster AD, Tollett J, Samuel MA, Engle M, Diamond MS. Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis. Journal of Virology. 79: 11457-66. PMID 16103196 DOI: 10.1128/JVI.79.17.11457-11466.2005  1
2005 Klein RS, Rubin JB, Luster AD. Chemokines and Central Nervous System Physiology Current Topics in Membranes. 55: 159-187. DOI: 10.1016/S1063-5823(04)55007-X  1
2004 Diamond MS, Klein RS. West Nile virus: crossing the blood-brain barrier. Nature Medicine. 10: 1294-5. PMID 15580248 DOI: 10.1038/nm1204-1294  1
2004 Klein RS, Rubin JB. Immune and nervous system CXCL12 and CXCR4: parallel roles in patterning and plasticity. Trends in Immunology. 25: 306-14. PMID 15145320 DOI: 10.1016/j.it.2004.04.002  1
2004 Klein RS. Regulation of neuroinflammation: the role of CXCL10 in lymphocyte infiltration during autoimmune encephalomyelitis. Journal of Cellular Biochemistry. 92: 213-22. PMID 15108349 DOI: 10.1002/jcb.20052  1
2004 Klein RS, Izikson L, Means T, Gibson HD, Lin E, Sobel RA, Weiner HL, Luster AD. IFN-inducible protein 10/CXC chemokine ligand 10-independent induction of experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 172: 550-9. PMID 14688366  1
2003 Rubin JB, Kung AL, Klein RS, Chan JA, Sun Y, Schmidt K, Kieran MW, Luster AD, Segal RA. A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proceedings of the National Academy of Sciences of the United States of America. 100: 13513-8. PMID 14595012 DOI: 10.1073/pnas.2235846100  1
2002 Izikson L, Klein RS, Luster AD, Weiner HL. Targeting monocyte recruitment in CNS autoimmune disease. Clinical Immunology (Orlando, Fla.). 103: 125-31. PMID 12027417 DOI: 10.1006/clim.2001.5167  1
2002 Borghesani PR, Peyrin JM, Klein R, Rubin J, Carter AR, Schwartz PM, Luster A, Corfas G, Segal RA. BDNF stimulates migration of cerebellar granule cells. Development (Cambridge, England). 129: 1435-42. PMID 11880352  1
2001 Klein RS, Rubin JB, Gibson HD, DeHaan EN, Alvarez-Hernandez X, Segal RA, Luster AD. SDF-1 alpha induces chemotaxis and enhances Sonic hedgehog-induced proliferation of cerebellar granule cells. Development (Cambridge, England). 128: 1971-81. PMID 11493520  1
2001 Lu Q, Sun EE, Klein RS, Flanagan JG. Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction. Cell. 105: 69-79. PMID 11301003 DOI: 10.1016/S0092-8674(01)00297-5  1
2000 Izikson L, Klein RS, Charo IF, Weiner HL, Luster AD. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. The Journal of Experimental Medicine. 192: 1075-80. PMID 11015448 DOI: 10.1084/jem.192.7.1075  1
1999 Klein RS, Williams KC, Alvarez-Hernandez X, Westmoreland S, Force T, Lackner AA, Luster AD. Chemokine receptor expression and signaling in macaque and human fetal neurons and astrocytes: implications for the neuropathogenesis of AIDS. Journal of Immunology (Baltimore, Md. : 1950). 163: 1636-46. PMID 10415069  1
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