Year |
Citation |
Score |
2023 |
Molinaro C, Kelly S, Tang A, Iding H, Stocker P, Linghu X, Gosselin F. Asymmetric Synthesis of -Alkyl Amino Acids through a Biocatalytic Dynamic Kinetic Resolution of PEGylated -Alkyl Amino Esters. Organic Letters. PMID 38051775 DOI: 10.1021/acs.orglett.3c03784 |
0.312 |
|
2019 |
Wong N, Petronijević F, Hong AY, Linghu X, Kelly SM, Hou H, Cravillion T, Lim NK, Robinson SJ, Han C, Molinaro C, Sowell CG, Gosselin F. Stereocontrolled Synthesis of Arylomycin-Based Gram-Negative Antibiotic GDC-5338. Organic Letters. PMID 31668077 DOI: 10.1021/Acs.Orglett.9B03481 |
0.567 |
|
2018 |
Lim NK, Linghu X, Wong N, Zhang H, Sowell CG, Gosselin F. Macrolactamization Approaches to Arylomycin Antibiotics Core. Organic Letters. PMID 30565949 DOI: 10.1021/Acs.Orglett.8B03603 |
0.397 |
|
2018 |
Chen Z, Hong AY, Linghu X. Construction of Polycyclic β-Ketoesters using a Homoconjugate Addition / Decarboxylative Dieckmann Annulation Strategy. The Journal of Organic Chemistry. PMID 29766724 DOI: 10.1021/Acs.Joc.8B00754 |
0.469 |
|
2018 |
Linghu X, Segraves NL, Abramovich I, Wong N, Müller B, Neubauer N, Fantasia S, Rieth S, Bachmann S, Jansen M, Sowell CG, Askin D, Koenig SG, Gosselin F. Cover Feature: Highly Efficient Synthesis of a Staphylococcus aureus Targeting Payload to Enable the First Antibody–Antibiotic Conjugate (Chem. Eur. J. 12/2018) Chemistry: a European Journal. 24: 2792-2792. DOI: 10.1002/Chem.201706013 |
0.325 |
|
2017 |
Linghu X, Segraves N, Abramovich I, Wong N, Müller B, Neubauer N, Fantasia S, Rieth S, Bachmann S, Jansen M, Sowell CG, Askin D, Koenig S, Gosselin F. Highly Efficient Synthesis of a Staphylococcus aureus-targeting Payload, Enabling the First Antibody-Antibiotic Conjugate. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29164727 DOI: 10.1002/Chem.201705392 |
0.4 |
|
2017 |
Linghu X, Wong N, Jost V, Fantasia S, Sowell CG, Gosselin F. Kumada–Corriu Heteroaryl Cross-Coupling for Synthesis of a Pharmaceutical Intermediate: Comparison of Batch Versus Continuous Reaction Modes Organic Process Research & Development. 21: 1320-1325. DOI: 10.1021/Acs.Oprd.7B00185 |
0.601 |
|
2017 |
Linghu X, Wong N, Iding H, Jost V, Zhang H, Koenig SG, Sowell CG, Gosselin F. Development of a Practical Synthesis of ERK Inhibitor GDC-0994 Organic Process Research & Development. 21: 387-398. DOI: 10.1021/Acs.Oprd.7B00006 |
0.488 |
|
2017 |
Yang S, Linghu X, Smith E, Pan J, Sprague V, Su J. Synthesis of bicyclic β-lactamase inhibitor relabactam derivatives from a relabactam intermediate Tetrahedron Letters. 58: 2838-2841. DOI: 10.1016/J.Tetlet.2017.06.018 |
0.45 |
|
2016 |
Staben LR, Koenig SG, Lehar SM, Vandlen R, Zhang D, Chuh J, Yu SF, Ng C, Guo J, Liu Y, Fourie-O'Donohue A, Go M, Linghu X, Segraves NL, Wang T, et al. Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates. Nature Chemistry. 8: 1112-1119. PMID 27874860 DOI: 10.1038/Nchem.2635 |
0.306 |
|
2014 |
Wong B, Linghu X, Crawford JJ, Drobnick J, Lee W, Zhang H. A chemoselective Reformatsky-Negishi approach to α-haloaryl esters Tetrahedron. 70: 1508-1515. DOI: 10.1016/J.Tet.2013.12.053 |
0.46 |
|
2013 |
McLaughlin M, Belyk K, Chen CY, Linghu X, Pan J, Qian G, Reamer RA, Xu Y. Practical asymmetric synthesis of a chiral piperazinone derivative Organic Process Research and Development. 17: 1052-1060. DOI: 10.1021/Op400150W |
0.442 |
|
2012 |
Boyce GR, Greszler SN, Johnson JS, Linghu X, Malinowski JT, Nicewicz DA, Satterfield AD, Schmitt DC, Steward KM. Silyl glyoxylates. Conception and realization of flexible conjunctive reagents for multicomponent coupling. The Journal of Organic Chemistry. 77: 4503-15. PMID 22414181 DOI: 10.1021/Jo300184H |
0.493 |
|
2012 |
Goodyear A, Linghu X, Bishop B, Chen C, Cleator E, McLaughlin M, Sheen FJ, Stewart GW, Xu Y, Yin. J. Process development and large-scale synthesis of MK-6186, a non-nucleoside reverse transcriptase inhibitor for the treatment of HIV Organic Process Research and Development. 16: 605-611. DOI: 10.1021/Op200334X |
0.354 |
|
2012 |
Linghu X, McLaughlin M, Chen CY, Reamer RA, Dimichele L, Davies IW. Synthesis of functionalized 3-chloro-1-naphthols via Friedel-Crafts acylation of vinyl chlorides Tetrahedron Letters. 53: 1550-1552. DOI: 10.1016/J.Tetlet.2012.01.011 |
0.59 |
|
2008 |
Linghu X, Kennedy-Smith JJ, Toste FD. Synthesis of (+)-Fawcettimine Synfacts. 2008: 124-124. DOI: 10.1055/S-2007-992500 |
0.414 |
|
2007 |
Linghu X, Kennedy-Smith JJ, Toste FD. Total synthesis of (+)-fawcettimine. Angewandte Chemie (International Ed. in English). 46: 7671-3. PMID 17729226 DOI: 10.1002/Anie.200702695 |
0.758 |
|
2006 |
Staben ST, Linghu X, Toste FD. Enantioselective synthesis of gamma-hydroxyenones by chiral base-catalyzed Kornblum DeLaMare rearrangement. Journal of the American Chemical Society. 128: 12658-9. PMID 17002354 DOI: 10.1021/Ja065464X |
0.753 |
|
2006 |
Linghu X, Satterfield AD, Johnson JS. Symbiotic reagent activation: Oppenauer oxidation of magnesium alkoxides by silylglyoxylates triggers second-stage aldolization. Journal of the American Chemical Society. 128: 9302-3. PMID 16848444 DOI: 10.1021/Ja062637+ |
0.75 |
|
2006 |
Toste F, Staben S, Linghu X. Organocatalytic Asymmetric Kornblum-DeLaMare Rearrangement Synfacts. 2006: 1175-1175. DOI: 10.1055/S-2006-949454 |
0.737 |
|
2005 |
Nahm MR, Linghu X, Potnick JR, Yates CM, White PS, Johnson JS. Metallophosphite-induced nucleophilic acylation of alpha,beta-unsaturated amides: facilitated catalysis by a diastereoselective retro [1,4] Brook rearrangement. Angewandte Chemie (International Ed. in English). 44: 2377-9. PMID 15761891 DOI: 10.1002/Anie.200462795 |
0.706 |
|
2005 |
Linghu X, Bausch CC, Johnson JS. Mechanism and scope of the cyanide-catalyzed cross silyl benzoin reaction. Journal of the American Chemical Society. 127: 1833-40. PMID 15701019 DOI: 10.1021/Ja044086Y |
0.807 |
|
2004 |
Linghu X, Potnick JR, Johnson JS. Metallophosphites as umpolung catalysts: the enantioselective cross silyl benzoin reaction. Journal of the American Chemical Society. 126: 3070-1. PMID 15012135 DOI: 10.1021/Ja0496468 |
0.69 |
|
2003 |
Linghu X, Johnson JS. Kinetic control in direct alpha-silyloxy ketone synthesis: a new regiospecific catalyzed cross silyl benzoin reaction. Angewandte Chemie (International Ed. in English). 42: 2534-6. PMID 12800180 DOI: 10.1002/Anie.200250554 |
0.656 |
|
2002 |
Linghu X, Nicewicz DA, Johnson JS. Tandem carbon-carbon bond constructions via catalyzed cyanation/Brook rearrangement/C-acylation reactions of acylsilanes. Organic Letters. 4: 2957-60. PMID 12182598 DOI: 10.1021/Ol0263649 |
0.787 |
|
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