David M. Hilbert - Publications

Affiliations: 
1983-1987 Immunology Graduate Group University of Pennsylvania Perelman School of Medicine 
 1987-1995 Laboratory of Genetics NIH, NCI 
 1995-2005 Research and Development Human Genome Sciences 
 2010- Founder, VP for research Cellective Therapeutics 

39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Buonato JM, Edwards JP, Zaritskaya L, Witter AR, Gupta A, LaFleur DW, Tice DA, Richman LK, Hilbert DM. Preclinical Efficacy of BCMA-Directed CAR T Cells Incorporating a Novel D Domain Antigen Recognition Domain. Molecular Cancer Therapeutics. OF1-OF13. PMID 35737298 DOI: 10.1158/1535-7163.MCT-21-0552  0.324
2020 Mu J, Edwards J, Zaritskaya L, Swers J, Gupta A, LaFleur D, Hilbert D, Richman L. Selective targeting of HER2-overexpressing solid tumors with a next-generation CAR-T cell therapy. Journal of Clinical Oncology. 38: 3041-3041. DOI: 10.1200/Jco.2020.38.15_Suppl.3041  0.386
2019 Qin H, Edwards JP, Zaritskaya L, Gupta A, Mu CJ, Fry TJ, Hilbert DM, LaFleur DW. Chimeric Antigen Receptors Incorporating D Domains Targeting CD123 Direct Potent Mono- and Bi-specific Antitumor Activity of T Cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 31043341 DOI: 10.1016/J.Ymthe.2019.04.010  0.309
2012 Stohl W, Hilbert DM. The discovery and development of belimumab: the anti-BLyS-lupus connection. Nature Biotechnology. 30: 69-77. PMID 22231104 DOI: 10.1038/Nbt.2076  0.363
2008 Woodland RT, Fox CJ, Schmidt MR, Hammerman PS, Opferman JT, Korsmeyer SJ, Hilbert DM, Thompson CB. Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. Blood. 111: 750-60. PMID 17942753 DOI: 10.1182/Blood-2007-03-077222  0.679
2006 Cambridge G, Stohl W, Leandro MJ, Migone TS, Hilbert DM, Edwards JC. Circulating levels of B lymphocyte stimulator in patients with rheumatoid arthritis following rituximab treatment: relationships with B cell depletion, circulating antibodies, and clinical relapse. Arthritis and Rheumatism. 54: 723-32. PMID 16508933 DOI: 10.1002/Art.21650  0.562
2004 Stohl W, Metyas S, Tan SM, Cheema GS, Oamar B, Roschke V, Wu Y, Baker KP, Hilbert DM. Inverse association between circulating APRIL levels and serological and clinical disease activity in patients with systemic lupus erythematosus. Annals of the Rheumatic Diseases. 63: 1096-103. PMID 15308519 DOI: 10.1136/Ard.2003.018663  0.335
2003 Stohl W, Metyas S, Tan SM, Cheema GS, Oamar B, Xu D, Roschke V, Wu Y, Baker KP, Hilbert DM. B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: longitudinal observations. Arthritis and Rheumatism. 48: 3475-86. PMID 14673998 DOI: 10.1002/Art.11354  0.431
2003 Baker KP, Edwards BM, Main SH, Choi GH, Wager RE, Halpern WG, Lappin PB, Riccobene T, Abramian D, Sekut L, Sturm B, Poortman C, Minter RR, Dobson CL, Williams E, ... ... Hilbert DM, et al. Generation and characterization of LymphoStat-B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator. Arthritis and Rheumatism. 48: 3253-65. PMID 14613291 DOI: 10.1002/Art.11299  0.568
2003 Stewart DM, McAvoy MJ, Hilbert DM, Nelson DL. B lymphocytes from individuals with common variable immunodeficiency respond to B lymphocyte stimulator (BLyS protein) in vitro. Clinical Immunology (Orlando, Fla.). 109: 137-43. PMID 14597212 DOI: 10.1016/S1521-6616(03)00215-8  0.591
2003 Tan SM, Xu D, Roschke V, Perry JW, Arkfeld DG, Ehresmann GR, Migone TS, Hilbert DM, Stohl W. Local production of B lymphocyte stimulator protein and APRIL in arthritic joints of patients with inflammatory arthritis. Arthritis and Rheumatism. 48: 982-92. PMID 12687540 DOI: 10.1002/Art.10860  0.452
2002 Nardelli B, Moore PA, Li Y, Hilbert DM. B lymphocyte stimulator (BLyS): a therapeutic trichotomy for the treatment of B lymphocyte diseases. Leukemia & Lymphoma. 43: 1367-73. PMID 12389615 DOI: 10.1080/10428190290033297  0.632
2002 Roschke V, Sosnovtseva S, Ward CD, Hong JS, Smith R, Albert V, Stohl W, Baker KP, Ullrich S, Nardelli B, Hilbert DM, Migone TS. BLyS and APRIL form biologically active heterotrimers that are expressed in patients with systemic immune-based rheumatic diseases. Journal of Immunology (Baltimore, Md. : 1950). 169: 4314-21. PMID 12370363 DOI: 10.4049/Jimmunol.169.8.4314  0.378
2002 Stohl W, Cheema GS, Briggs WS, Xu D, Sosnovtseva S, Roschke V, Ferrara DE, Labat K, Sattler FR, Pierangeli SS, Hilbert DM. B lymphocyte stimulator protein-associated increase in circulating autoantibody levels may require CD4+ T cells: lessons from HIV-infected patients. Clinical Immunology (Orlando, Fla.). 104: 115-22. PMID 12165272 DOI: 10.1006/Clim.2002.5238  0.38
2002 Litinskiy MB, Nardelli B, Hilbert DM, He B, Schaffer A, Casali P, Cerutti A. DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL. Nature Immunology. 3: 822-9. PMID 12154359 DOI: 10.1038/Ni829  0.442
2002 Hsu BL, Harless SM, Lindsley RC, Hilbert DM, Cancro MP. Cutting edge: BLyS enables survival of transitional and mature B cells through distinct mediators. Journal of Immunology (Baltimore, Md. : 1950). 168: 5993-6. PMID 12055205 DOI: 10.4049/Jimmunol.168.12.5993  0.66
2002 Briones J, Timmerman JM, Hilbert DM, Levy R. BLyS and BLyS receptor expression in non-Hodgkin's lymphoma. Experimental Hematology. 30: 135-41. PMID 11823048 DOI: 10.1016/S0301-472X(01)00774-3  0.503
2001 Harless SM, Lentz VM, Sah AP, Hsu BL, Clise-Dwyer K, Hilbert DM, Hayes CE, Cancro MP. Competition for BLyS-mediated signaling through Bcmd/BR3 regulates peripheral B lymphocyte numbers. Current Biology : Cb. 11: 1986-9. PMID 11747827 DOI: 10.1016/S0960-9822(01)00598-X  0.57
2001 Cheema GS, Roschke V, Hilbert DM, Stohl W. Elevated serum B lymphocyte stimulator levels in patients with systemic immune-based rheumatic diseases. Arthritis and Rheumatism. 44: 1313-9. PMID 11407690 DOI: 10.1002/1529-0131(200106)44:6<1313::Aid-Art223>3.0.Co;2-S  0.37
2001 Kanakaraj P, Migone TS, Nardelli B, Ullrich S, Li Y, Olsen HS, Salcedo TW, Kaufman T, Cochrane E, Gan Y, Hilbert DM, Giri J. BLyS BINDS TO B CELLS WITH HIGH AFFINITY AND INDUCES ACTIVATION OF THE TRANSCRIPTION FACTORS NF-kappaB AND ELF-1. Cytokine. 13: 25-31. PMID 11145839 DOI: 10.1006/Cyto.2000.0793  0.515
2001 Nardelli B, Belvedere O, Roschke V, Moore PA, Olsen HS, Migone TS, Sosnovtseva S, Carrell JA, Feng P, Giri JG, Hilbert DM. Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood. 97: 198-204. PMID 11133761 DOI: 10.1182/Blood.V97.1.198  0.556
2000 Do RK, Hatada E, Lee H, Tourigny MR, Hilbert D, Chen-Kiang S. Attenuation of apoptosis underlies B lymphocyte stimulator enhancement of humoral immune response. The Journal of Experimental Medicine. 192: 953-64. PMID 11015437 DOI: 10.1084/Jem.192.7.953  0.689
2000 Belvedere O, Feruglio C, Malangone W, Bonora ML, Minisini AM, Spizzo R, Donini A, Sala P, De Anna D, Hilbert DM, Degrassi A. Increased blood volume and CD34(+)CD38(-) progenitor cell recovery using a novel umbilical cord blood collection system. Stem Cells (Dayton, Ohio). 18: 245-51. PMID 10924090 DOI: 10.1634/Stemcells.18-4-245  0.317
1999 Gronowski AM, Hilbert DM, Sheehan KC, Garotta G, Schreiber RD. Baculovirus stimulates antiviral effects in mammalian cells. Journal of Virology. 73: 9944-51. PMID 10559307 DOI: 10.1128/Jvi.73.12.9944-9951.1999  0.372
1999 Moore PA, Belvedere O, Orr A, Pieri K, LaFleur DW, Feng P, Soppet D, Charters M, Gentz R, Parmelee D, Li Y, Galperina O, Giri J, Roschke V, Nardelli B, ... ... Hilbert DM, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science (New York, N.Y.). 285: 260-3. PMID 10398604 DOI: 10.1126/Science.285.5425.260  0.658
1998 Hilbert DM, Theisen PW, Rudikoff EK, Bauer SR. Interaction of abl and raf with IL-7 signaling pathway and transformation of pre-B cells from resistant mice. Oncogene. 17: 2125-35. PMID 9798684 DOI: 10.1038/Sj.Onc.1202134  0.552
1996 Fernandez-Salguero PM, Hilbert DM, Rudikoff S, Ward JM, Gonzalez FJ. Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicology and Applied Pharmacology. 140: 173-9. PMID 8806883 DOI: 10.1006/Taap.1996.0210  0.338
1996 Hilbert DM, Migone TS, Kopf M, Leonard WJ, Rudikoff S. Distinct tumorigenic potential of abl and raf in B cell neoplasia: abl activates the IL-6 signaling pathway. Immunity. 5: 81-9. PMID 8758897 DOI: 10.1016/S1074-7613(00)80312-X  0.408
1996 Lisignoli G, Monaco MC, Facchini A, Toneguzzi S, Cattini L, Hilbert DM, Lavaroni S, Belvedere O, Degrassi A. In vitro cultured stromal cells from human tonsils display a distinct phenotype and induce B cell adhesion and proliferation. European Journal of Immunology. 26: 17-27. PMID 8566062 DOI: 10.1002/Eji.1830260104  0.452
1995 Hilbert DM, Shen MY, Rapp UR, Rudikoff S. T cells induce terminal differentiation of transformed B cells to mature plasma cell tumors. Proceedings of the National Academy of Sciences of the United States of America. 92: 649-53. PMID 7846031 DOI: 10.1073/Pnas.92.3.649  0.595
1995 Hilbert DM, Kopf M, Mock BA, Köhler G, Rudikoff S. Interleukin 6 is essential for in vivo development of B lineage neoplasms. The Journal of Experimental Medicine. 182: 243-8. PMID 7790819 DOI: 10.1084/Jem.182.1.243  0.388
1995 Fernandez-Salguero P, Pineau T, Hilbert DM, McPhail T, Lee SS, Kimura S, Nebert DW, Rudikoff S, Ward JM, Gonzalez FJ. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science (New York, N.Y.). 268: 722-6. PMID 7732381 DOI: 10.1126/Science.7732381  0.313
1994 Hilbert DM, Anderson AO, Holmes KL, Rudikoff S. Long-term lymphoid reconstitution of SCID mice suggests self-renewing B and T cell populations in peripheral and mucosal tissues. Transplantation. 58: 466-75. PMID 8073516 DOI: 10.1097/00007890-199408270-00013  0.494
1994 Nazarov V, Hilbert D, Wolff L. Susceptibility and resistance to Moloney murine leukemia virus-induced promonocytic leukemia. Virology. 205: 479-85. PMID 7975249 DOI: 10.1006/Viro.1994.1668  0.321
1993 Degrassi A, Hilbert DM, Rudikoff S, Anderson AO, Potter M, Coon HG. In vitro culture of primary plasmacytomas requires stromal cell feeder layers. Proceedings of the National Academy of Sciences of the United States of America. 90: 2060-4. PMID 8446628 DOI: 10.1073/Pnas.90.5.2060  0.552
1993 Hilbert DM, Holmes KL, Anderson AO, Rudikoff S. Long-term thymic reconstitution by peripheral CD4 and CD8 single-positive lymphocytes. European Journal of Immunology. 23: 2412-8. PMID 8405041 DOI: 10.1002/Eji.1830231006  0.372
1990 Degrassi A, Hilbert DM, Anderson AO, Potter M, Coon HG. In vitro culture of a primary plasmacytoma that has retained its dependence on pristane conditioned microenvironment for growth. Current Topics in Microbiology and Immunology. 166: 71-4. PMID 2073818 DOI: 10.1007/978-3-642-75889-8_10  0.41
1986 Hilbert DM, Cancro MP. A comparative analysis of the anti-phosphorylcholine response of CLA and BALB/c mice. Current Topics in Microbiology and Immunology. 127: 206-17. PMID 3089697 DOI: 10.1007/978-3-642-71304-0_24  0.459
1983 Cancro MP, Thompson MA, Hilbert DM. Developmental aspects of B-cell repertoire phenotype. Survey of Immunologic Research. 2: 62-77. PMID 6359323 DOI: 10.1007/BF02918397  0.806
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