Pierre Blier, MD, PhD - Publications

Affiliations: 
University of Ottawa, Ottawa, ON, Canada 

298 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Daniels S, El Mansari M, Blier P. AMPA receptors modulate enhanced dopamine neuronal activity induced by the combined administration of venlafaxine and brexpiprazole. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 39147870 DOI: 10.1038/s41386-024-01958-4  0.497
2023 Daniels S, El Mansari M, Hamoudeh R, Blier P. Ketamine promptly normalizes excess norepinephrine and enhances dopamine neuronal activity in Wistar Kyoto rats. Frontiers in Pharmacology. 14: 1276309. PMID 38026921 DOI: 10.3389/fphar.2023.1276309  0.405
2023 El Mansari M, Hamoudeh R, Daniels S, Blier P. Wistar Kyoto rats exhibit decreased serotonin neuronal firing and increased norepinephrine burst activity but dampened hippocampal α-adrenoceptor sensitivity. Journal of Psychopharmacology (Oxford, England). 37: 1105-1115. PMID 37942525 DOI: 10.1177/02698811231209235  0.453
2021 Aldosary F, Norris S, Tremblay P, James JS, Ritchie JC, Blier P. Differential potency of venlafaxine, paroxetine, and atomoxetine to inhibit serotonin and norepinephrine reuptake in patients with major depressive disorder. The International Journal of Neuropsychopharmacology. PMID 34958348 DOI: 10.1093/ijnp/pyab086  0.364
2021 Iro CM, Hamati R, El Mansari M, Blier P. Repeated but not single administration of ketamine prolongs increases of the firing activity of norepinephrine and dopamine neurons. The International Journal of Neuropsychopharmacology. PMID 33674836 DOI: 10.1093/ijnp/pyab010  0.388
2020 El Mansari M, Ebrahimzadeh M, Hamati R, Iro CM, Farkas B, Kiss B, Adham N, Blier P. Long-term administration of cariprazine increases locus coeruleus noradrenergic neurons activity and serotonin receptor neurotransmission in the hippocampus. Journal of Psychopharmacology (Oxford, England). 269881120936891. PMID 32684081 DOI: 10.1177/0269881120936891  0.684
2020 Uher R, Frey BN, Quilty LC, Rotzinger S, Blier P, Foster JA, Müller DJ, Ravindran AV, Soares CN, Turecki G, Parikh SV, Milev R, MacQueen G, Lam RW, Kennedy SH, et al. Symptom Dimension of Interest-Activity Indicates Need for Aripiprazole Augmentation of Escitalopram in Major Depressive Disorder: A CAN-BIND-1 Report. The Journal of Clinical Psychiatry. 81. PMID 32558407 DOI: 10.4088/Jcp.20M13229  0.338
2020 Phillips JL, Jaworska N, Kamler E, Bhat V, Blier J, Foster JA, Hassel S, Ho K, McMurray L, Milev R, Moazamigoudarzi Z, Placenza FM, Richard-Devantoy S, Rotzinger S, Turecki G, ... ... Blier P, et al. A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: a Canadian biomarker integration network in depression (CAN-BIND) study protocol. Bmc Psychiatry. 20: 268. PMID 32487236 DOI: 10.1186/S12888-020-02672-3  0.33
2020 de la Salle S, Jaworska N, Blier P, Smith D, Knott V. Using prefrontal and midline right frontal EEG-derived theta cordance and depressive symptoms to predict the differential response or remission to antidepressant treatment in major depressive disorder. Psychiatry Research. Neuroimaging. 302: 111109. PMID 32480044 DOI: 10.1016/J.Pscychresns.2020.111109  0.331
2020 Jiang JL, El Mansari M, Blier P. Triple reuptake inhibition of serotonin, norepinephrine, and dopamine increases the tonic activation of α-adrenoceptors in the rat hippocampus and dopamine levels in the nucleus accumbens. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 109987. PMID 32474007 DOI: 10.1016/J.Pnpbp.2020.109987  0.569
2020 Hamati R, El Mansari M, Blier P. Serotonin-2B receptor antagonism increases the activity of dopamine and glutamate neurons in the presence of selective serotonin reuptake inhibition. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32473594 DOI: 10.1038/S41386-020-0723-Y  0.587
2019 Daniels S, Horman T, Lapointe T, Melanson B, Storace A, Kennedy SH, Frey BN, Rizvi SJ, Hassel S, Mueller DJ, Parikh SV, Lam RW, Blier P, Farzan F, Giacobbe P, et al. Reverse translation of major depressive disorder symptoms: A framework for the behavioural phenotyping of putative biomarkers. Journal of Affective Disorders. 263: 353-366. PMID 31969265 DOI: 10.1016/J.Jad.2019.11.108  0.31
2019 Talbot J, Phillips JL, Blier P. Ketamine for chronic depression: two cautionary tales Journal of Psychiatry & Neuroscience : Jpn. 44: 190073. PMID 31573153 DOI: 10.1503/Jpn.190073  0.343
2019 Fedgchin M, Trivedi M, Daly EJ, Melkote R, Lane R, Lim P, Vitagliano D, Blier P, Fava M, Liebowitz M, Ravindran A, Gaillard R, Ameele HVD, Preskorn S, Manji H, et al. Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1). The International Journal of Neuropsychopharmacology. PMID 31290965 DOI: 10.1093/Ijnp/Pyz039  0.338
2019 Daly EJ, Trivedi MH, Janik A, Li H, Zhang Y, Li X, Lane R, Lim P, Duca AR, Hough D, Thase ME, Zajecka J, Winokur A, Divacka I, Fagiolini A, ... ... Blier P, et al. Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial. Jama Psychiatry. PMID 31166571 DOI: 10.1001/Jamapsychiatry.2019.1189  0.326
2019 Phillips JL, Norris S, Talbot J, Birmingham M, Hatchard T, Ortiz A, Owoeye O, Batten LA, Blier P. Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial. The American Journal of Psychiatry. appiajp201818070834. PMID 30922101 DOI: 10.1176/Appi.Ajp.2018.18070834  0.358
2019 Kennedy SH, Lam RW, Rotzinger S, Milev RV, Blier P, Downar J, Evans KR, Farzan F, Foster JA, Frey BN, Giacobbe P, Hall GB, Harkness KL, Hassel S, Ismail Z, et al. Symptomatic and Functional Outcomes and Early Prediction of Response to Escitalopram Monotherapy and Sequential Adjunctive Aripiprazole Therapy in Patients With Major Depressive Disorder: A CAN-BIND-1 Report. The Journal of Clinical Psychiatry. 80. PMID 30840787 DOI: 10.4088/Jcp.18M12202  0.304
2019 Fedgchin M, Trivedi M, Daly EJ, Melkote R, Lane R, Lim P, Vitagliano D, Blier P, Fava M, Liebowitz M, Ravindran A, Gaillard R, Ameele Hvd, Manjii H, Hough D, et al. Randomized, Double-Blind Study of Fixed-Dose Intranasal Esketamine Plus Oral Antidepressant vs. Active Control in Treatment-Resistant Depression Journal of Affective Disorders. 254: 131-132. DOI: 10.1016/J.Jad.2018.10.289  0.325
2019 Daly EJ, Trivedi M, Janik A, Li H, Zhang Y, Li X, Lane R, Duca AR, Hough D, Thase ME, Zajecka J, Winokur A, Divacka I, Fagiolini A, Cubala WJ, ... ... Blier P, et al. Esketamine nasal spray combined with an oral antidepressant for relapse prevention in treatment-resistant depression: results of a double-blind, randomized withdrawal, multicenter study (sustain-1) European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2018.11.1076  0.329
2019 Iro C, Mansari ME, Blier P. Repeated subanesthetic administration of ketamine maintains an increase in dopamine neurotransmission: an electrophysiological study in rat brain European Neuropsychopharmacology. 29: S78. DOI: 10.1016/J.Euroneuro.2018.11.1058  0.331
2019 Iro M, El Mansari M, Blier P. S131. Repeated but not Acute Administration of Ketamine Maintained the Enhanced Activity of Dopamine and Norepinephrine Neurons in Rats Biological Psychiatry. 85: S347. DOI: 10.1016/J.Biopsych.2019.03.882  0.389
2019 Hamati R, El Mansari M, Blier P. S130. Synergistic Action of Aripiprazole and Escitalopram Potentiates Medial Prefrontal Cortical Activity Through Blockade of 5-HT2B Receptors Biological Psychiatry. 85: S346-S347. DOI: 10.1016/J.Biopsych.2019.03.881  0.3
2018 Zuilhof Z, Norris S, Blondeau C, Tessier P, Blier P. Optimized regimens of combined medications for the treatment of major depressive disorder: a double-blind, randomized-controlled trial. Neuropsychiatric Disease and Treatment. 14: 3209-3218. PMID 30538479 DOI: 10.2147/Ndt.S175203  0.32
2018 Ebrahimzadeh M, El Mansari M, Blier P. Synergistic effect of aripiprazole and escitalopram in increasing serotonin but not norepinephrine neurotransmission in the rat hippocampus. Neuropharmacology. PMID 30414871 DOI: 10.1016/J.Neuropharm.2018.11.006  0.724
2018 Herman A, El Mansari M, Adham N, Kiss B, Farkas B, Blier P. Involvement of 5-HT and 5-HT Receptors but Not -Adrenoceptors in the Acute Electrophysiological Effects of Cariprazine in the Rat Brain In Vivo. Molecular Pharmacology. 94: 1363-1370. PMID 30322874 DOI: 10.1124/Mol.118.113290  0.571
2018 Jaworska N, Wang H, Smith DM, Blier P, Knott V, Protzner AB. Pre-treatment EEG signal variability is associated with treatment success in depression. Neuroimage. Clinical. 17: 368-377. PMID 29159049 DOI: 10.1016/J.Nicl.2017.10.035  0.308
2018 Phillips J, Norris S, Talbot J, Ortiz A, Birmingham M, Blier P. S160. Antidepressant Effects of Single and Repeated Ketamine Infusions in Treatment-Resistant Depression Biological Psychiatry. 83: S410. DOI: 10.1016/J.Biopsych.2018.02.1052  0.342
2017 Ebrahimzadeh M, El Mansari M, Blier P. Partial inhibition of catecholamine activity and enhanced responsiveness to NMDA after sustained administration of vortioxetine. Neuropharmacology. PMID 29102760 DOI: 10.1016/J.Neuropharm.2017.10.036  0.677
2017 Oluboka OJ, Katzman MA, Habert J, McIntosh D, MacQueen GM, Milev RV, McIntyre RS, Blier P. Functional Recovery in Major Depressive Disorder: Providing Early Optimal Treatment for the Individual Patient. The International Journal of Neuropsychopharmacology. PMID 29024974 DOI: 10.1093/Ijnp/Pyx081  0.307
2017 Blier P, Ebrahimzadeh M, El Mansari M. 660. Effect of Combining Aripiprazole with Escitalopram on Serotonergic and Noradrenergic Neurotransmission in the Rat Hippocampus Biological Psychiatry. 81: S267. DOI: 10.1016/J.Biopsych.2017.02.1069  0.602
2016 Blier P, Gommoll C, Chen C, Kramer K. Effects of levomilnacipran ER on noradrenergic symptoms, anxiety symptoms, and functional impairment in adults with major depressive disorder: Post hoc analysis of 5 clinical trials. Journal of Affective Disorders. 210: 273-279. PMID 28068615 DOI: 10.1016/J.Jad.2016.11.011  0.306
2016 Nutt D, Stahl S, Blier P, Drago F, Zohar J, Wilson S. Inverse agonists - What do they mean for psychiatry? European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 27955830 DOI: 10.1016/J.Euroneuro.2016.11.013  0.37
2016 Blier P. Neurobiology of depression and mechanism of action of depression treatments. The Journal of Clinical Psychiatry. 77: e319. PMID 27046319 DOI: 10.4088/Jcp.13097Tx3C  0.469
2016 Montoya A, Bruins R, Katzman MA, Blier P. The noradrenergic paradox: implications in the management of depression and anxiety. Neuropsychiatric Disease and Treatment. 12: 541-57. PMID 27042068 DOI: 10.2147/Ndt.S91311  0.351
2015 Oosterhof CA, El Mansari M, Bundgaard C, Blier P. Brexpiprazole alters monoaminergic systems following repeated administration: an in vivo electrophysiological study. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). PMID 26428352 DOI: 10.1093/Ijnp/Pyv111  0.319
2015 Etiévant A, Oosterhof C, Bétry C, Abrial E, Novo-Perez M, Rovera R, Scarna H, Devader C, Mazella J, Wegener G, Sánchez C, Dkhissi-Benyahya O, Gronfier C, Coizet V, Beaulieu JM, ... Blier P, et al. Astroglial Control of the Antidepressant-Like Effects of Prefrontal Cortex Deep Brain Stimulation. Ebiomedicine. 2: 896-906. PMID 26425697 DOI: 10.1016/J.Ebiom.2015.06.023  0.409
2015 El Mansari M, Crnic A, Oosterhof C, Blier P. Long-term administration of the antidepressant vilazodone modulates rat brain monoaminergic systems. Neuropharmacology. 99: 696-704. PMID 26362359 DOI: 10.1016/J.Neuropharm.2015.09.007  0.584
2015 El Iskandrani KS, Oosterhof CA, El Mansari M, Blier P. Impact of subanesthetic doses of ketamine on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons. Journal of Psychopharmacology (Oxford, England). 29: 792-801. PMID 25759403 DOI: 10.1177/0269881115573809  0.472
2015 El Mansari M, Lecours M, Blier P. Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain. Psychopharmacology. 232: 2343-52. PMID 25665528 DOI: 10.1007/S00213-015-3870-9  0.534
2015 Oosterhof CA, El Mansari M, Blier P. Asenapine alters the activity of monoaminergic systems following its subacute and long-term administration: an in vivo electrophysiological characterization. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 25: 531-43. PMID 25656272 DOI: 10.1016/J.Euroneuro.2015.01.006  0.523
2015 El Mansari M, Manta S, Oosterhof C, El Iskandrani KS, Chenu F, Shim S, Blier P. Restoration of serotonin neuronal firing following long-term administration of bupropion but not paroxetine in olfactory bulbectomized rats. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 18. PMID 25522394 DOI: 10.1093/Ijnp/Pyu050  0.504
2015 Ebrahimzadeh M, El Mansari M, Blier P. P.2.a.014 Effect of subacute and long-term administration of vortioxetine on firing activity of catecholaminergic neurons European Neuropsychopharmacology. 25: S382-S383. DOI: 10.1016/S0924-977X(15)30498-3  0.588
2014 Schatzberg AF, Blier P, Culpepper L, Jain R, Papakostas GI, Thase ME. An overview of vortioxetine. The Journal of Clinical Psychiatry. 75: 1411-8. PMID 25551236 DOI: 10.4088/Jcp.14027Ah1  0.349
2014 Gerra ML, Marchesi C, Amat JA, Blier P, Hellerstein DJ, Stewart JW. Does negative affectivity predict differential response to an SSRI versus a non-SSRI antidepressant? The Journal of Clinical Psychiatry. 75: e939-44. PMID 25295437 DOI: 10.4088/Jcp.14M09025  0.338
2014 Oosterhof CA, El Mansari M, Blier P. Acute effects of brexpiprazole on serotonin, dopamine, and norepinephrine systems: an in vivo electrophysiologic characterization. The Journal of Pharmacology and Experimental Therapeutics. 351: 585-95. PMID 25225185 DOI: 10.1124/Jpet.114.218578  0.548
2014 Blier P, El Mansari M. The importance of serotonin and noradrenaline in anxiety. International Journal of Psychiatry in Clinical Practice. 16-23. PMID 24926868 DOI: 10.1080/13651500701388310  0.466
2014 Blier P, El Mansari M. The importance of serotonin and noradrenaline in anxiety. International Journal of Psychiatry in Clinical Practice. 16-23. PMID 24926868 DOI: 10.1080/13651500701388310  0.466
2014 Blier P. Dual serotonin and noradrenaline reuptake inhibitors: Focus on their differences. International Journal of Psychiatry in Clinical Practice. 22-32. PMID 24921679 DOI: 10.1080/13651500600645612  0.45
2014 Blier P. Dual serotonin and noradrenaline reuptake inhibitors: Focus on their differences. International Journal of Psychiatry in Clinical Practice. 22-32. PMID 24921679 DOI: 10.1080/13651500600645612  0.45
2014 Stewart JW, McGrath PJ, Blondeau C, Deliyannides DA, Hellerstein D, Norris S, Amat J, Pilowsky DJ, Tessier P, Laberge L, O'Shea D, Chen Y, Withers A, Bergeron R, Blier P. Combination antidepressant therapy for major depressive disorder: speed and probability of remission. Journal of Psychiatric Research. 52: 7-14. PMID 24485847 DOI: 10.1016/J.Jpsychires.2013.12.001  0.342
2014 Chenu F, Shim S, El Mansari M, Blier P. Role of melatonin, serotonin 2B, and serotonin 2C receptors in modulating the firing activity of rat dopamine neurons. Journal of Psychopharmacology (Oxford, England). 28: 162-7. PMID 24189440 DOI: 10.1177/0269881113510071  0.572
2014 Blier P. Rational site-directed pharmacotherapy for major depressive disorder. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 17: 997-1008. PMID 23745670 DOI: 10.1017/S1461145713000400  0.548
2014 Oosterhof C, El Mansari M, Blier P. P.2.a.011 In vivo electrophysiological characterisation of the acute effects of brexpiprazole administration on monoamine systems European Neuropsychopharmacology. 24: S367. DOI: 10.1016/S0924-977X(14)70586-3  0.357
2013 Blier P. Neurotransmitter targeting in the treatment of depression. The Journal of Clinical Psychiatry. 74: 19-24. PMID 24191974 DOI: 10.4088/Jcp.12084Su1C.04  0.33
2013 Shim S, El Mansari M, Blier P. Modulation of the antidepressant-like effects of sustained administration of carisbamate and lamotrigine on monoaminergic systems: electrophysiological studies in the rat brain. The Journal of Pharmacology and Experimental Therapeutics. 347: 487-96. PMID 23986541 DOI: 10.1124/Jpet.113.203315  0.604
2013 Blier P. Exploiting N-methyl-d-aspartate channel blockade for a rapid antidepressant response in major depressive disorder. Biological Psychiatry. 74: 238-9. PMID 23885752 DOI: 10.1016/J.Biopsych.2013.05.029  0.302
2013 Tsen P, El Mansari M, Blier P. Effects of repeated electroconvulsive shocks on catecholamine systems: electrophysiological studies in the rat brain. Synapse (New York, N.Y.). 67: 716-27. PMID 23740835 DOI: 10.1002/Syn.21685  0.474
2013 Jaworska N, De Somma E, Blondeau C, Tessier P, Norris S, Fusee W, Smith D, Blier P, Knott V. Auditory P3 in antidepressant pharmacotherapy treatment responders, non-responders and controls. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 23: 1561-9. PMID 23664712 DOI: 10.1016/J.Euroneuro.2013.03.003  0.301
2013 Hamon M, Blier P. Monoamine neurocircuitry in depression and strategies for new treatments. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 45: 54-63. PMID 23602950 DOI: 10.1016/J.Pnpbp.2013.04.009  0.517
2013 Blier P, El Mansari M. Serotonin and beyond: therapeutics for major depression. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 368: 20120536. PMID 23440470 DOI: 10.1098/rstb.2012.0536  0.463
2013 Jaworska N, Blondeau C, Tessier P, Norris S, Fusee W, Blier P, Knott V. Response prediction to antidepressants using scalp and source-localized loudness dependence of auditory evoked potential (LDAEP) slopes. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 44: 100-7. PMID 23360662 DOI: 10.1016/J.Pnpbp.2013.01.012  0.433
2013 Chenu F, El Mansari M, Blier P. Electrophysiological effects of repeated administration of agomelatine on the dopamine, norepinephrine, and serotonin systems in the rat brain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 275-84. PMID 22871919 DOI: 10.1038/Npp.2012.140  0.579
2013 Manta S, El Mansari M, Debonnel G, Blier P. Electrophysiological and neurochemical effects of long-term vagus nerve stimulation on the rat monoaminergic systems. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 459-70. PMID 22717062 DOI: 10.1017/S1461145712000387  0.527
2013 El Mansari M, El Iskandarani K, Oosterhof C, Blier P. P.2.a.012 Electrophysiological effects of low doses of ketamine on the firing activity of norepinephrine and dopamine neurons European Neuropsychopharmacology. 23: S315. DOI: 10.1016/S0924-977X(13)70494-2  0.38
2013 El Mansari M, Chenu F, Blier P. P.2.a.008 Role of melatonin, 5-HT2B, and 5-HT2C receptors in modulating the firing activity of rat dopamine neurons European Neuropsychopharmacology. 23: S312-S313. DOI: 10.1016/S0924-977X(13)70490-5  0.431
2012 Fountoulakis KN, Kasper S, Andreassen O, Blier P, Okasha A, Severus E, Versiani M, Tandon R, Möller HJ, Vieta E. Efficacy of pharmacotherapy in bipolar disorder: a report by the WPA section on pharmacopsychiatry. European Archives of Psychiatry and Clinical Neuroscience. 262: 1-48. PMID 22622948 DOI: 10.1007/S00406-012-0323-X  0.331
2012 Koszycki D, Bisserbe JC, Blier P, Bradwejn J, Markowitz J. Interpersonal psychotherapy versus brief supportive therapy for depressed infertile women: first pilot randomized controlled trial. Archives of Women's Mental Health. 15: 193-201. PMID 22526405 DOI: 10.1007/S00737-012-0277-Z  0.313
2012 Jaworska N, Blier P, Fusee W, Knott V. Scalp- and sLORETA-derived loudness dependence of auditory evoked potentials (LDAEPs) in unmedicated depressed males and females and healthy controls. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology. 123: 1769-78. PMID 22425485 DOI: 10.1016/J.Clinph.2012.02.076  0.324
2012 Phillips JL, Batten LA, Aldosary F, Tremblay P, Blier P. Brain-volume increase with sustained remission in patients with treatment-resistant unipolar depression. The Journal of Clinical Psychiatry. 73: 625-31. PMID 22394416 DOI: 10.4088/Jcp.11M06865  0.31
2012 Chernoloz O, El Mansari M, Blier P. Effects of sustained administration of quetiapine alone and in combination with a serotonin reuptake inhibitor on norepinephrine and serotonin transmission. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1717-28. PMID 22373941 DOI: 10.1038/Npp.2012.18  0.85
2012 Blier P. Combined treatments for depression as for other medical disorders. The American Journal of Psychiatry. 169: 95; author reply 95-. PMID 22223012 DOI: 10.1176/Appi.Ajp.2011.11071055  0.317
2012 Ghanbari R, El Mansari M, Blier P. Electrophysiological impact of trazodone on the dopamine and norepinephrine systems in the rat brain. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 22: 518-26. PMID 22154666 DOI: 10.1016/J.Euroneuro.2011.11.005  0.767
2012 Baghai TC, Blier P, Baldwin DS, Bauer M, Goodwin GM, Fountoulakis KN, Kasper S, Leonard BE, Malt UF, Stein DJ, Versiani M, Möller HJ. Executive summary of the report by the WPA section on pharmacopsychiatry on general and comparative efficacy and effectiveness of antidepressants in the acute treatment of depressive disorders. European Archives of Psychiatry and Clinical Neuroscience. 262: 13-22. PMID 22083391 DOI: 10.1007/S00406-011-0274-7  0.362
2012 Manta S, El Mansari M, Blier P. Novel attempts to optimize vagus nerve stimulation parameters on serotonin neuronal firing activity in the rat brain. Brain Stimulation. 5: 422-9. PMID 22037140 DOI: 10.1016/J.Brs.2011.04.005  0.494
2012 Chernoloz O, El Mansari M, Blier P. Long-term administration of the dopamine D3/2 receptor agonist pramipexole increases dopamine and serotonin neurotransmission in the male rat forebrain. Journal of Psychiatry & Neuroscience : Jpn. 37: 113-21. PMID 22023785 DOI: 10.1503/Jpn.110038  0.841
2012 Chenu F, Ghanbari R, El Mansari M, Blier P. An enhancement of the firing activity of dopamine neurons as a common denominator of antidepressant treatments? The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 15: 551-3; author reply . PMID 21906420 DOI: 10.1017/S1461145711001362  0.582
2012 Guiard BP, Mansari ME, Murphy DL, Blier P. Altered response to the selective serotonin reuptake inhibitor escitalopram in mice heterozygous for the serotonin transporter: an electrophysiological and neurochemical study. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 15: 349-61. PMID 21439106 DOI: 10.1017/S1461145711000484  0.518
2012 Lecours M, El Mansari M, Blier P. P.2.b.015 Electrophysiological effects of the multimodal antidepressant Lu AA21004 on serotonin transmission in the rat hippocampus European Neuropsychopharmacology. 22: S249. DOI: 10.1016/S0924-977X(12)70372-3  0.394
2011 Baghai TC, Blier P, Baldwin DS, Bauer M, Goodwin GM, Fountoulakis KN, Kasper S, Leonard BE, Malt UF, Stein D, Versiani M, Möller HJ. General and comparative efficacy and effectiveness of antidepressants in the acute treatment of depressive disorders: a report by the WPA section of pharmacopsychiatry. European Archives of Psychiatry and Clinical Neuroscience. 261: 207-45. PMID 22033583 DOI: 10.1007/S00406-011-0259-6  0.358
2011 Blier P, Briley M. The noradrenergic symptom cluster: clinical expression and neuropharmacology. Neuropsychiatric Disease and Treatment. 7: 15-20. PMID 21750624 DOI: 10.2147/Ndt.S19613  0.54
2011 Kennedy SH, Young AH, Blier P. Strategies to achieve clinical effectiveness: refining existing therapies and pursuing emerging targets. Journal of Affective Disorders. 132: S21-8. PMID 21571374 DOI: 10.1016/J.Jad.2011.03.048  0.332
2011 Ghanbari R, El Mansari M, Blier P. Enhancement of serotonergic and noradrenergic neurotransmission in the rat hippocampus by sustained administration of bupropion. Psychopharmacology. 217: 61-73. PMID 21445565 DOI: 10.1007/S00213-011-2260-1  0.76
2011 Berney A, Leyton M, Gravel P, Sibon I, Sookman D, Rosa Neto P, Diksic M, Nakai A, Pinard G, Todorov C, Okazawa H, Blier P, Nordahl TE, Benkelfat C. Brain regional α-[11C]methyl-L-tryptophan trapping in medication-free patients with obsessive-compulsive disorder. Archives of General Psychiatry. 68: 732-41. PMID 21383250 DOI: 10.1001/Archgenpsychiatry.2011.16  0.348
2011 Mnie-Filali O, Faure C, Lambás-Señas L, El Mansari M, Belblidia H, Gondard E, Etiévant A, Scarna H, Didier A, Berod A, Blier P, Haddjeri N. Pharmacological blockade of 5-HT7 receptors as a putative fast acting antidepressant strategy. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1275-88. PMID 21326194 DOI: 10.1038/Npp.2011.13  0.568
2011 Blier P, Blondeau C. Neurobiological bases and clinical aspects of the use of aripiprazole in treatment-resistant major depressive disorder. Journal of Affective Disorders. 128: S3-10. PMID 21220079 DOI: 10.1016/S0165-0327(11)70003-9  0.484
2011 Guiard BP, Chenu F, El Mansari M, Blier P. Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 14: 211-23. PMID 20149268 DOI: 10.1017/S1461145710000076  0.564
2011 Chernoloz O, El Mansari M, Blier P. P.2.d.026 Chronic administration of quetiapine increases norepinephrine and serotonin neurotransmission in the rat brain European Neuropsychopharmacology. 21: S416-S417. DOI: 10.1016/S0924-977X(11)70672-1  0.787
2011 Chenu F, El Mansari M, Blier P. P.2.d.014 Electrophysiological effects of repeated agomelatine administration on the serotonin, norepinephrine, dopamine systems in the rat brain European Neuropsychopharmacology. 21: S409. DOI: 10.1016/S0924-977X(11)70660-5  0.384
2011 Phillips J, Batten L, Aldosary F, Tremblay P, Du L, Blier P. P.1.e.023 Influence of the 5-HTTLPR polymorphism on brain structure in treatment-resistant major depressive disorder European Neuropsychopharmacology. 21: S316-S317. DOI: 10.1016/S0924-977X(11)70501-6  0.313
2010 Ghanbari R, El Mansari M, Blier P. Sustained administration of trazodone enhances serotonergic neurotransmission: in vivo electrophysiological study in the rat brain. The Journal of Pharmacology and Experimental Therapeutics. 335: 197-206. PMID 20647493 DOI: 10.1124/Jpet.110.169417  0.745
2010 Blier P. The well of novel antidepressants: running dry. Journal of Psychiatry & Neuroscience : Jpn. 35: 219-20. PMID 20569647 DOI: 10.1503/Jpn.100098  0.476
2010 El Mansari M, Guiard BP, Chernoloz O, Ghanbari R, Katz N, Blier P. Relevance of norepinephrine-dopamine interactions in the treatment of major depressive disorder. Cns Neuroscience & Therapeutics. 16: e1-17. PMID 20406250 DOI: 10.1111/J.1755-5949.2010.00146.X  0.805
2010 Blier P. Altered function of the serotonin 1A autoreceptor and the antidepressant response. Neuron. 65: 1-2. PMID 20152106 DOI: 10.1016/J.Neuron.2009.12.028  0.489
2010 Blier P, Ward HE, Tremblay P, Laberge L, Hébert C, Bergeron R. Combination of antidepressant medications from treatment initiation for major depressive disorder: a double-blind randomized study. The American Journal of Psychiatry. 167: 281-8. PMID 20008946 DOI: 10.1176/Appi.Ajp.2009.09020186  0.391
2010 Katz NS, Guiard BP, El Mansari M, Blier P. Effects of acute and sustained administration of the catecholamine reuptake inhibitor nomifensine on the firing activity of monoaminergic neurons. Journal of Psychopharmacology (Oxford, England). 24: 1223-35. PMID 19939862 DOI: 10.1177/0269881109348178  0.536
2010 Ghanbari R, El Mansari M, Blier P. Electrophysiological effects of the co-administration of escitalopram and bupropion on rat serotonin and norepinephrine neurons Journal of Psychopharmacology. 24: 39-50. PMID 18719044 DOI: 10.1177/0269881108095714  0.753
2010 Ghanbari R, El Mansari M, Blier P. P.1.c.055 Electrophysiological effects of sustained administration of trazodone on serotonin system European Neuropsychopharmacology. 20: S266-S267. DOI: 10.1016/S0924-977X(10)70342-4  0.653
2010 Ghanbari R, El Mansari M, Blier P. P.1.c.054 Sustained administration of bupropion enhances serotonergic and noradrenergic neurotransmission in the rat hippocampus European Neuropsychopharmacology. 20: S265-S266. DOI: 10.1016/S0924-977X(10)70341-2  0.645
2009 Dremencov E, el Mansari M, Blier P. Brain norepinephrine system as a target for antidepressant and mood stabilizing medications. Current Drug Targets. 10: 1061-8. PMID 19702556 DOI: 10.2174/138945009789735165  0.378
2009 Guiard BP, El Mansari M, Blier P. Prospect of a dopamine contribution in the next generation of antidepressant drugs: the triple reuptake inhibitors. Current Drug Targets. 10: 1069-84. PMID 19702555 DOI: 10.2174/138945009789735156  0.554
2009 Chernoloz O, El Mansari M, Blier P. Electrophysiological studies in the rat brain on the basis for aripiprazole augmentation of antidepressants in major depressive disorder. Psychopharmacology. 206: 335-44. PMID 19641901 DOI: 10.1007/S00213-009-1611-7  0.849
2009 Manta S, Dong J, Debonnel G, Blier P. Enhancement of the function of rat serotonin and norepinephrine neurons by sustained vagus nerve stimulation. Journal of Psychiatry & Neuroscience : Jpn. 34: 272-80. PMID 19568478  0.456
2009 Dremencov E, El Mansari M, Blier P. Effects of sustained serotonin reuptake inhibition on the firing of dopamine neurons in the rat ventral tegmental area. Journal of Psychiatry & Neuroscience : Jpn. 34: 223-9. PMID 19448853  0.494
2009 Blier P, Gobbi G, Turcotte JE, de Montigny C, Boucher N, Hébert C, Debonnel G. Mirtazapine and paroxetine in major depression: a comparison of monotherapy versus their combination from treatment initiation. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 19: 457-65. PMID 19345072 DOI: 10.1016/J.Euroneuro.2009.01.015  0.591
2009 Manta S, Dong J, Debonnel G, Blier P. Optimization of vagus nerve stimulation parameters using the firing activity of serotonin neurons in the rat dorsal raphe. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 19: 250-5. PMID 19150228 DOI: 10.1016/J.Euroneuro.2008.12.001  0.532
2009 Ghanbari R, El Mansari M, Shahid M, Blier P. Electrophysiological characterization of the effects of asenapine at 5-HT1A, 5-HT2A, α2-adrenergic and D2 receptors in the rat brain European Neuropsychopharmacology. 19: 177-187. PMID 19116183 DOI: 10.1016/J.Euroneuro.2008.11.001  0.73
2009 Chenu F, Mansari ME, Blier P. Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area International Journal of Neuropsychopharmacology. 12: 475-485. PMID 18700056 DOI: 10.1017/S1461145708009218  0.556
2009 Chernoloz O, Mansari ME, Blier P. Sustained administration of pramipexole modifies the spontaneous firing of dopamine, norepinephrine, and serotonin neurons in the rat brain Neuropsychopharmacology. 34: 651-661. PMID 18688211 DOI: 10.1038/Npp.2008.114  0.849
2009 Zghoul T, Blier P. Enhancing action of LSD on neuronal responsiveness to serotonin in a brain structure involved in obsessive-compulsive disorder. The International Journal of Neuropsychopharmacology. 6: 13-21. PMID 12899732 DOI: 10.1017/S1461145702003218  0.578
2009 Guiard B, Chenu F, El Mansari M, Blier P. P.1.c.059 Electrophysiological properties of the triple reuptake inhibitor SEP 225289 on monoaminergic neurons European Neuropsychopharmacology. 19: S285. DOI: 10.1016/S0924-977X(09)70419-5  0.559
2009 Manta S, Dong J, Debonnel G, Blier P. P.1.20 Impact of vagus nerve stimulation on monoaminergic neurons European Neuropsychopharmacology. 19: S18-S19. DOI: 10.1016/S0924-977X(09)70023-9  0.302
2009 Chernoloz O, Mansari ME, Blier P. P.1.07 Effects of pramipexole administration on monoaminergic neurotransmission European Neuropsychopharmacology. 19: S8-S8. DOI: 10.1016/S0924-977X(09)70010-0  0.769
2008 Haddjeri N, Blier P. Neurokinin-1 receptor antagonists modulate brain noradrenaline and serotonin interactions European Journal of Pharmacology. 600: 64-70. PMID 18930727 DOI: 10.1016/j.ejphar.2008.10.001  0.468
2008 El Mansari M, Ghanbari R, Janssen S, Blier P. Sustained administration of bupropion alters the neuronal activity of serotonin, norepinephrine but not dopamine neurons in the rat brain Neuropharmacology. 55: 1191-1198. PMID 18708076 DOI: 10.1016/J.Neuropharm.2008.07.028  0.738
2008 Guiard BP, El Mansari M, Blier P. Cross-talk between dopaminergic and noradrenergic systems in the rat ventral tegmental area, locus ceruleus, and dorsal hippocampus. Molecular Pharmacology. 74: 1463-75. PMID 18703671 DOI: 10.1124/Mol.108.048033  0.457
2008 Trivedi MH, Hollander E, Nutt D, Blier P. Clinical evidence and potential neurobiological underpinnings of unresolved symptoms of depression Journal of Clinical Psychiatry. 69: 246-258. PMID 18363453 DOI: 10.4088/Jcp.V69N0211  0.319
2008 Guiard BP, El Mansari M, Merali Z, Blier P. Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 11: 625-39. PMID 18205979 DOI: 10.1017/S1461145707008383  0.527
2008 El Mansari M, Blier P. In vivo electrophysiological assessment of the putative antidepressant Wf-516 in the rat raphe dorsalis, locus coeruleus and hippocampus Naunyn-Schmiedeberg's Archives of Pharmacology. 376: 351-361. PMID 18060386 DOI: 10.1007/S00210-007-0210-6  0.55
2008 Okazawa H, Yamane F, Blier P, Diksic M. Effects of Acute and Chronic Administration of the Serotonin1A Agonist Buspirone on Serotonin Synthesis in the Rat Brain Journal of Neurochemistry. 72: 2022-2031. PMID 10217280 DOI: 10.1046/J.1471-4159.1999.0722022.X  0.496
2008 Dremencov E, El Mansari M, Blier P. P.2.d.025 SSRI-induced inhibition of dopamine neuronal activity is reversed by antagonism of serotonin-2C receptors European Neuropsychopharmacology. 18: S359. DOI: 10.1016/S0924-977X(08)70507-8  0.446
2008 Chenu F, El Mansari M, Blier P. P.1.09 Prolonged monoamine oxidase inhibition alters the firing activity of dopamine neurons in the ventral tegmental area European Neuropsychopharmacology. 18: s9. DOI: 10.1016/S0924-977X(08)70010-5  0.38
2008 Ghanbari R, El Mansari M, Blier P. 243 – Characterization of the in vivo actions of asenapine at 5-HT1A, 5-HT2A and alpha-2a-adrenergic receptors in the rat brain Schizophrenia Research. 98: 133-134. DOI: 10.1016/J.Schres.2007.12.310  0.635
2007 Montgomery SA, Baldwin DS, Blier P, Fineberg NA, Kasper S, Lader M, Lam RW, Lépine JP, Möller HJ, Nutt DJ, Rouillon F, Schatzberg AF, Thase ME. Which antidepressants have demonstrated superior efficacy? A review of the evidence. International Clinical Psychopharmacology. 22: 323-9. PMID 17917550 DOI: 10.1097/Yic.0B013E3282Eff7E0  0.334
2007 Weiss M, Blier P, Montigny Cd. Effect of long-term administration of the antidepressant drug milnacipran on serotonergic and noradrenergic neurotransmission in the rat hippocampus Life Sciences. 81: 166-176. PMID 17568622 DOI: 10.1016/J.Lfs.2007.04.039  0.54
2007 Dremencov E, El Mansari M, Blier P. Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neurons Psychopharmacology. 194: 63-72. PMID 17530476 DOI: 10.1007/S00213-007-0818-8  0.576
2007 Gobbi G, Cassano T, Radja F, Morgese MG, Cuomo V, Santarelli L, Hen R, Blier P. Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 17: 328-38. PMID 16950604 DOI: 10.1016/J.Euroneuro.2006.07.004  0.683
2007 Dremencov E, El Mansari M, Blier P. Noradrenergic Augmentation of Escitalopram Response by Risperidone: Electrophysiologic Studies in the Rat Brain Biological Psychiatry. 61: 671-678. PMID 16934772 DOI: 10.1016/J.Biopsych.2006.05.015  0.527
2007 Debonnel G, Saint-André E, Hébert C, De Montigny C, Lavoie N, Blier P. Differential physiological effects of a low dose and high doses of venlafaxine in major depression International Journal of Neuropsychopharmacology. 10: 51-61. PMID 16690006 DOI: 10.1017/S1461145705006413  0.499
2007 Blier P, Saint-André E, Hébert C, De Montigny C, Lavoie N, Debonnel G. Effects of different doses of venlafaxine on serotonin and norepinephrine reuptake in healthy volunteers International Journal of Neuropsychopharmacology. 10: 41-50. PMID 16690005 DOI: 10.1017/S1461145705006395  0.49
2007 Dunner DL, Blier P, Keller MB, Pollack MH, Thase ME, Zajecka JM. Preventing recurrent depression: Long-term treatment for major depressive disorder Primary Care Companion to the Journal of Clinical Psychiatry. 9: 214-223. DOI: 10.4088/Jcp.0307E06  0.311
2007 Ghanbari R, El Mansari M, Blier P. P.3.d.023 In vivo characterization of the effects of asenapine at 5-HT1A, 5-HT2A and a2A-adrenergic receptors in the rat brain European Neuropsychopharmacology. 17: S486-S487. DOI: 10.1016/S0924-977X(07)70744-7  0.651
2007 Guiard B, El Mansari M, Merali Z, Blier P. P.2.d.026 Functional interactions between serotonin, norepinephrine and dopamine neurons: an electrophysiological study European Neuropsychopharmacology. 17: S376. DOI: 10.1016/S0924-977X(07)70555-2  0.405
2007 Dremencov E, El Mansari M, Blier P. P.2.d.021 Distinct electrophysiological effects of citalopram and escitalopram on mesolimbic dopamine neuronal activity in rats European Neuropsychopharmacology. 17: S373-S374. DOI: 10.1016/S0924-977X(07)70550-3  0.409
2007 El Mansari M, Ghanbari R, Janssen S, Blier P. P.2.d.016 Effects of long-term treatment with bupropion on the firing activity of serotonin and norepinephrine neurons European Neuropsychopharmacology. 17: S370-S371. DOI: 10.1016/S0924-977X(07)70545-X  0.684
2007 Manta S, Dong J, Blier P, Debonnel G. P.2.d.012 Vagus nerve stimulation: effects on noradrenergic neuronal firing and serotonin transmission in the rat brain European Neuropsychopharmacology. 17: S368-S369. DOI: 10.1016/S0924-977X(07)70541-2  0.403
2006 Blier P, Habib R, Flament MF. Pharmacotherapies in the management of obsessive-compulsive disorder Canadian Journal of Psychiatry. 51: 417-430. PMID 16838823 DOI: 10.1177/070674370605100703  0.448
2006 Blier P, Tremblay P. Physiologic mechanisms underlying the antidepressant discontinuation syndrome. The Journal of Clinical Psychiatry. 67: 8-13. PMID 16683857  0.4
2006 Tremblay P, Blier P. Catecholaminergic strategies for the treatment of major depression. Current Drug Targets. 7: 149-58. PMID 16475956 DOI: 10.2174/138945006775515464  0.437
2006 El Mansari M, Blier P. Mechanisms of action of current and potential pharmacotherapies of obsessive-compulsive disorder Progress in Neuro-Psychopharmacology and Biological Psychiatry. 30: 362-373. PMID 16427729 DOI: 10.1016/J.Pnpbp.2005.11.005  0.534
2006 Guiard B, Gardier A, Blier P. Potentiating antidepressant strategy: focus on NK1 receptor antagonists European Neuropsychopharmacology. 16: S31-S32. DOI: 10.1016/S0924-977X(06)80039-8  0.334
2006 Dremencov E, El Mansari M, Blier P. Augmentation of antidepressant response by atypical antipsychotic drugs: electrophysiological studies in the rat brain European Neuropsychopharmacology. 16: S29-S30. DOI: 10.1016/S0924-977X(06)80037-4  0.334
2006 Blier P. C.16.03 The importance of serotonin (5-HT) and noradrenaline (NA) in anxiety European Neuropsychopharmacology. 16: S586. DOI: 10.1016/S0924-977X(06)70858-6  0.363
2005 Blier P, Szabo ST. Potential mechanisms of action of atypical antipsychotic medications in treatment-resistant depression and anxiety. The Journal of Clinical Psychiatry. 66: 30-40. PMID 16336034  0.741
2005 El Mansari M, Blier P. Responsiveness of 5-HT(1A) and 5-HT2 receptors in the rat orbitofrontal cortex after long-term serotonin reuptake inhibition. Journal of Psychiatry & Neuroscience : Jpn. 30: 268-74. PMID 16049570  0.444
2005 Gobbi G, Blier P. Effect of neurokinin-1 receptor antagonists on serotoninergic, noradrenergic and hippocampal neurons: comparison with antidepressant drugs. Peptides. 26: 1383-93. PMID 16042978 DOI: 10.1016/J.Peptides.2005.03.032  0.678
2005 Blier P, Ward H. Toward optimal treatments for major depression. Cns Spectrums. 7: 148-50, 153-4. PMID 15220857 DOI: 10.1017/S1092852900017466  0.351
2004 Rosa-Neto P, Diksic M, Okazawa H, Leyton M, Ghadirian N, Mzengeza S, Nakai A, Debonnel G, Blier P, Benkelfat C. Measurement of brain regional alpha-[11C]methyl-L-tryptophan trapping as a measure of serotonin synthesis in medication-free patients with major depression. Archives of General Psychiatry. 61: 556-63. PMID 15184235 DOI: 10.1001/Archpsyc.61.6.556  0.301
2004 Blier P, Gobbi G, Haddjeri N, Santarelli L, Mathew G, Hen R. Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic response. Journal of Psychiatry & Neuroscience : Jpn. 29: 208-18. PMID 15173897  0.678
2004 Haddjeri N, Faure C, Lucas G, Mnie-Filali O, Chouvet G, Astier B, Renaud B, Blier P, Debonnel G. In-vivo modulation of central 5-hydroxytryptamine (5-HT1A) receptor-mediated responses by the cholinergic system. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 7: 391-9. PMID 15140278 DOI: 10.1017/S1461145704004377  0.515
2004 Haddjeri N, Lavoie N, Blier P. Electrophysiological evidence for the tonic activation of 5-HT1A autoreceptors in the rat dorsal raphe nucleus Neuropsychopharmacology. 29: 1800-1806. PMID 15127086 DOI: 10.1038/Sj.Npp.1300489  0.554
2004 Szabo ST, Gold MS, Goldberger BA, Blier P. Effects of sustained gamma-hydroxybutyrate treatments on spontaneous and evoked firing activity of locus coeruleus norepinephrine neurons. Biological Psychiatry. 55: 934-9. PMID 15110737 DOI: 10.1016/J.Biopsych.2003.12.013  0.692
2004 Shapira NA, Ward HE, Mandoki M, Murphy TK, Yang MC, Blier P, Goodman WK. A double-blind, placebo-controlled trial of olanzapine addition in fluoxetine-refractory obsessive-compulsive disorder. Biological Psychiatry. 55: 553-5. PMID 15023585 DOI: 10.1016/J.Biopsych.2003.11.010  0.314
2003 Gobbi G, Slater S, Boucher N, Debonnel G, Blier P. Neurochemical and psychotropic effects of bupropion in healthy male subjects. Journal of Clinical Psychopharmacology. 23: 233-9. PMID 12826985 DOI: 10.1097/01.Jcp.0000084023.22282.03  0.701
2003 Blier P. The pharmacology of putative early-onset antidepressant strategies. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 13: 57-66. PMID 12650947 DOI: 10.1016/S0924-977X(02)00173-6  0.523
2003 Blier P, Ward NM. Is there a role for 5-HT1A agonists in the treatment of depression? Biological Psychiatry. 53: 193-203. PMID 12559651 DOI: 10.1016/S0006-3223(02)01643-8  0.484
2002 Santarelli L, Gobbi G, Blier P, Hen R. Behavioral and physiologic effects of genetic or pharmacologic inactivation of the substance P receptor (NK1). The Journal of Clinical Psychiatry. 63: 11-7. PMID 12562138  0.571
2002 Montgomery SA, Bech P, Blier P, Möller HJ, Nierenberg AA, Pinder RM, Quitkin FM, Reimitz PE, Rosenbaum JF, Rush AJ, Stassen HH, Thase ME. Selecting methodologies for the evaluation of differences in time to response between antidepressants. The Journal of Clinical Psychiatry. 63: 694-9. PMID 12197449 DOI: 10.4088/Jcp.V63N0806  0.323
2002 Szabo ST, Blier P. Effects of serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibition plus 5-HT(2A) receptor antagonism on the firing activity of norepinephrine neurons. The Journal of Pharmacology and Experimental Therapeutics. 302: 983-91. PMID 12183655 DOI: 10.1124/Jpet.102.033282  0.778
2002 Stockmeier CA, Shi X, Konick L, Overholser JC, Jurjus G, Meltzer HY, Friedman L, Blier P, Rajkowska G. Neurokinin-1 receptors are decreased in major depressive disorder. Neuroreport. 13: 1223-7. PMID 12151774 DOI: 10.1097/00001756-200207020-00031  0.358
2002 Blier P, Seletti B, Gilbert F, Young SN, Benkelfat C. Serotonin 1A receptor activation and hypothermia in humans: lack of evidence for a presynaptic mediation. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 27: 301-8. PMID 12093604 DOI: 10.1016/S0893-133X(02)00318-4  0.515
2002 Tohyama Y, Yamane F, Merid MF, Blier P, Diksic M. Effects of serotine receptors agonists, TFMPP and CGS12066B, on regional serotonin synthesis in the rat brain: an autoradiographic study. Journal of Neurochemistry. 80: 788-798. PMID 11948242 DOI: 10.1046/J.0022-3042.2002.00757.X  0.519
2002 Richer M, Hen R, Blier P. Modification of serotonin neuron properties in mice lacking 5-HT1A receptors. European Journal of Pharmacology. 435: 195-203. PMID 11821026 DOI: 10.1016/S0014-2999(01)01607-7  0.518
2002 Blier P. The Burden of Depression and the Challenge of its Recognition and Treatment Cns Spectrums. 7: 119-119. DOI: 10.1017/S1092852900017429  0.306
2002 Blier P, Dong J, Haddjeri N. Effect of the 5-HT1A agonist gepirone HCL and its metabolite 3′-OH-gepirone on the 5-HT system in the rat brain European Neuropsychopharmacology. 12: 229. DOI: 10.1016/S0924-977X(02)80271-1  0.387
2002 Haddjeri N, Chouvet G, Blier P, Zimmer L, Astier B, Renaud B, Debonnel G. 5-HT2/7 receptor antagonists potentiate the effects of antidepressants: An in vivo electrophysiological study European Neuropsychopharmacology. 12: 211. DOI: 10.1016/S0924-977X(02)80223-1  0.421
2001 Szabo ST, Blier P. Response of the norepinephrine system to antidepressant drugs. Cns Spectrums. 6: 679-84. PMID 15520619 DOI: 10.1017/S1092852900001371  0.663
2001 Blier P, Haddjeri N, Szabo ST, Dong J. Enhancement of serotoninergic function - a sometimes insufficient cause of antidepressant action. Human Psychopharmacology. 16: 23-27. PMID 12404594 DOI: 10.1002/Hup.179  0.638
2001 Szabo ST, Blier P. Effects of the selective norepinephrine reuptake inhibitor reboxetine on norepinephrine and serotonin transmission in the rat hippocampus. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 25: 845-57. PMID 11750178 DOI: 10.1016/S0893-133X(01)00284-6  0.775
2001 Szabo ST, Blier P. Serotonin (1A) receptor ligands act on norepinephrine neuron firing through excitatory amino acid and GABA(A) receptors: a microiontophoretic study in the rat locus coeruleus. Synapse (New York, N.Y.). 42: 203-12. PMID 11746719 DOI: 10.1002/Syn.10009  0.752
2001 Szabo ST, Blier P. Functional and pharmacological characterization of the modulatory role of serotonin on the firing activity of locus coeruleus norepinephrine neurons. Brain Research. 922: 9-20. PMID 11730697 DOI: 10.1016/S0006-8993(01)03121-3  0.766
2001 Yamane F, Okazawa H, Blier P, Diksic M. Reduction in serotonin synthesis following acute and chronic treatments with paroxetine, a selective serotonin reuptake inhibitor, in rat brain: an autoradiographic study with α-[14C]methyl-l-tryptophan Biochemical Pharmacology. 62: 1481-1489. PMID 11728384 DOI: 10.1016/S0006-2952(01)00798-5  0.475
2001 Szabo ST, Blier P. Effects of chronic antidepressant drug administration and electroconvulsive shock on locus coeruleus electrophysiologic activity. Biological Psychiatry. 50: 644-6. PMID 11690604 DOI: 10.1016/S0006-3223(01)01260-4  0.646
2001 Haddjeri N, Blier P. Sustained blockade of neurokinin-1 receptors enhances serotonin neurotransmission. Biological Psychiatry. 50: 191-9. PMID 11513818 DOI: 10.1016/S0006-3223(01)01162-3  0.524
2001 Szabo ST, Blier P. Effect of the selective noradrenergic reuptake inhibitor reboxetine on the firing activity of noradrenaline and serotonin neurons. The European Journal of Neuroscience. 13: 2077-87. PMID 11422448 DOI: 10.1046/J.0953-816X.2001.01583.X  0.76
2001 Dong J, Blier P. Modification of norepinephrine and serotonin, but not dopamine, neuron firing by sustained bupropion treatment. Psychopharmacology. 155: 52-7. PMID 11374336 DOI: 10.1007/S002130000665  0.393
2001 Leyton M, Okazawa H, Diksic M, Paris J, Rosa P, Mzengeza S, Young SN, Blier P, Benkelfat C. Brain Regional alpha-[11C]methyl-L-tryptophan trapping in impulsive subjects with borderline personality disorder. The American Journal of Psychiatry. 158: 775-82. PMID 11329401 DOI: 10.1176/Appi.Ajp.158.5.775  0.359
2001 Turcotte JE, Debonnel G, de Montigny C, Hébert C, Blier P. Assessment of the serotonin and norepinephrine reuptake blocking properties of duloxetine in healthy subjects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 24: 511-21. PMID 11282251 DOI: 10.1016/S0893-133X(00)00220-7  0.498
2001 Santarelli L, Gobbi G, Debs PC, Sibille ET, Blier P, Hen R, Heath MJ. Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proceedings of the National Academy of Sciences of the United States of America. 98: 1912-7. PMID 11172050 DOI: 10.1073/Pnas.98.4.1912  0.68
2001 Haddjeri N, Lucas G, Blier P. Role of cholinergic and GABAergic systems in the feedback inhibition of dorsal raphe 5-HT neurons. Neuroreport. 11: 3397-401. PMID 11059909 DOI: 10.1097/00001756-200010200-00026  0.501
2000 Szabo ST, de Montigny C, Blier P. Progressive attenuation of the firing activity of locus coeruleus noradrenergic neurons by sustained administration of selective serotonin reuptake inhibitors. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 3: 1-11. PMID 11343573 DOI: 10.1017/S1461145700001772  0.771
2000 Leyton M, Ghadirian AM, Young SN, Palmour RM, Blier P, Helmers KF, Benkelfat C. Depressive relapse following acute tryptophan depletion in patients with major depressive disorder. Journal of Psychopharmacology (Oxford, England). 14: 284-7. PMID 11106310 DOI: 10.1177/026988110001400317  0.357
2000 Béïque JC, Blier P, de Montigny C, Debonnel G. Potentiation by (-)Pindolol of the activation of postsynaptic 5-HT(1A) receptors induced by venlafaxine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 23: 294-306. PMID 10942853 DOI: 10.1016/S0893-133X(00)00112-3  0.548
2000 Béïque JC, Montigny CD, Blier P, Debonnel G. Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: II. In vitro studies in the rat Neuropharmacology. 39: 1813-1822. PMID 10884562 DOI: 10.1016/S0028-3908(00)00018-6  0.487
2000 Béïque JC, De Montigny C, Blier P, Debonnel G. Effects of sustained administration of the serotonin and norepinephrine reuptake inhibitor venlafaxine: I. In vivo electrophysiological studies in the rat Neuropharmacology. 39: 1800-1812. PMID 10884561 DOI: 10.1016/S0028-3908(00)00017-4  0.564
2000 Rueter LE, Tecott LH, Blier P. In vivo electrophysiological examination of 5-HT2 responses in 5-HT2C receptor mutant mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 361: 484-91. PMID 10832601 DOI: 10.1007/S002109900181  0.506
2000 Haddjeri N, Blier P. Effect of neurokinin-I receptor antagonists on the function of 5-HT and noradrenaline neurons. Neuroreport. 11: 1323-7. PMID 10817615 DOI: 10.1097/00001756-200004270-00035  0.566
2000 Besson A, Haddjeri N, Blier P, de Montigny C. Effects of the co-administration of mirtazapine and paroxetine on serotonergic neurotransmission in the rat brain. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 10: 177-88. PMID 10793320 DOI: 10.1016/S0924-977X(00)00069-9  0.565
2000 Haddjeri N, Szabo ST, de Montigny C, Blier P. Increased tonic activation of rat forebrain 5-HT(1A) receptors by lithium addition to antidepressant treatments. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 22: 346-56. PMID 10700654 DOI: 10.1016/S0893-133X(99)00138-4  0.774
2000 Tsuiki K, Blier P, Diksic M. Effect of the β-adrenoceptor agonist flerobuterol on serotonin synthesis in the rat brain Biochemical Pharmacology. 59: 673-679. PMID 10677584 DOI: 10.1016/S0006-2952(99)00364-0  0.473
2000 Leyton M, Young SN, Pihl RO, Etezadi S, Lauze C, Blier P, Baker GB, Benkelfat C. Effects on mood of acute phenylalanine/tyrosine depletion in healthy women. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 22: 52-63. PMID 10633491 DOI: 10.1016/S0893-133X(99)00086-X  0.325
2000 Haddjeri N, de Montigny C, Blier P. Modulation of the firing activity of rat serotonin and noradrenaline neurons by (+/-)pindolol. Biological Psychiatry. 45: 1163-9. PMID 10331108 DOI: 10.1016/S0006-3223(98)00354-0  0.488
2000 Debonnel G, Gobbi G, Turcotte J, Boucher N, Hébert C, De Montigny C, Blier P. Effects of mirtazapine, paroxetine and their combination: a double-blind study in major depression European Neuropsychopharmacology. 10: 252. DOI: 10.1016/S0924-977X(00)80213-8  0.561
2000 Szabo S, Blier P. The SSRI/5-HT2A antagonist YM992 produces inverse effects compared to SSRIs on the firing activity of noradrenergic neurons European Neuropsychopharmacology. 10: 249. DOI: 10.1016/S0924-977X(00)80206-0  0.456
2000 Blier P. Clinical consequences of the control of NA and 5-HT release in antidepressant therapy European Neuropsychopharmacology. 10: 161. DOI: 10.1016/S0924-977X(00)80065-6  0.424
1999 Dong J, De Montigny C, Blier P. Assessment of the serotonin reuptake blocking property of YM992: electrophysiological studies in the rat hippocampus and dorsal raphe. Synapse (New York, N.Y.). 34: 277-89. PMID 10529722 DOI: 10.1002/(Sici)1098-2396(19991215)34:4<277::Aid-Syn4>3.0.Co;2-W  0.556
1999 Haddjeri N, Ortemann C, de Montigny C, Blier P. Effect of sustained administration of the 5-HT1A receptor agonist flesinoxan on rat 5-HT neurotransmission. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 9: 427-40. PMID 10523050 DOI: 10.1016/S0924-977X(99)00020-6  0.58
1999 De Montigny C, Silverstone PH, Debonnel G, Blier P, Bakish D. Venlafaxine in treatment-resistant major depression: A Canadian multicenter, open-label trial Journal of Clinical Psychopharmacology. 19: 401-406. PMID 10505581 DOI: 10.1097/00004714-199910000-00003  0.344
1999 Blier P, de Montigny C. Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 21: 91S-98S. PMID 10432494 DOI: 10.1016/S0893-133X(99)00036-6  0.409
1999 Béïque JC, de Montigny C, Blier P, Debonnel G. Venlafaxine: discrepancy between in vivo 5-HT and NE reuptake blockade and affinity for reuptake sites. Synapse (New York, N.Y.). 32: 198-211. PMID 10340630 DOI: 10.1002/(Sici)1098-2396(19990601)32:3<198::Aid-Syn6>3.0.Co;2-2  0.556
1999 Haddjeri N, Blier P, de Montigny C. Acute and long-term actions of the antidepressant drug mirtazapine on central 5-HT neurotransmission. Journal of Affective Disorders. 51: 255-66. PMID 10333981 DOI: 10.1016/S0165-0327(98)00223-7  0.575
1999 Bergqvist PB, Dong J, Blier P. Effect of atypical antipsychotic drugs on 5-HT2 receptors in the rat orbito-frontal cortex: an in vivo electrophysiological study. Psychopharmacology. 143: 89-96. PMID 10227084 DOI: 10.1007/S002130050923  0.538
1999 Rueter LE, Blier P. Electrophysiological examination of the effects of sustained flibanserin administration on serotonin receptors in rat brain. British Journal of Pharmacology. 126: 627-38. PMID 10188973 DOI: 10.1038/Sj.Bjp.0702344  0.552
1999 Szabo ST, de Montigny C, Blier P. Modulation of noradrenergic neuronal firing by selective serotonin reuptake blockers. British Journal of Pharmacology. 126: 568-71. PMID 10188964 DOI: 10.1038/Sj.Bjp.0702343  0.753
1999 Bergqvist PB, Bouchard C, Blier P. Effect of long-term administration of antidepressant treatments on serotonin release in brain regions involved in obsessive-compulsive disorder. Biological Psychiatry. 45: 164-74. PMID 9951563 DOI: 10.1016/S0006-3223(98)00154-1  0.504
1999 Blier P, Piñeyro G, el Mansari M, Bergeron R, de Montigny C. Role of somatodendritic 5-HT autoreceptors in modulating 5-HT neurotransmission. Annals of the New York Academy of Sciences. 861: 204-16. PMID 9928258 DOI: 10.1111/J.1749-6632.1998.Tb10192.X  0.558
1999 Mongeau R, Weiss M, de Montigny C, Blier P. Effect of acute, short- and long-term milnacipran administration on rat locus coeruleus noradrenergic and dorsal raphe serotonergic neurons. Neuropharmacology. 37: 905-18. PMID 9776386 DOI: 10.1016/S0028-3908(98)00083-5  0.553
1998 Béïque JC, Debonnel G, de Montigny C, Blier P. Discrepancies between the in vitro and in vivo 5-HT and norepinephrine re-uptake blocking properties of venlafaxine. Annals of the New York Academy of Sciences. 861: 290-1. PMID 9928296 DOI: 10.1111/J.1749-6632.1998.Tb10230.X  0.474
1998 Ramboz S, Oosting R, Amara DA, Kung HF, Blier P, Mendelsohn M, Mann JJ, Brunner D, Hen R. Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proceedings of the National Academy of Sciences of the United States of America. 95: 14476-81. PMID 9826725 DOI: 10.1073/Pnas.95.24.14476  0.447
1998 Béïque JC, de Montigny C, Blier P, Debonnel G. Blockade of 5-hydroxytryptamine and noradrenaline uptake by venlafaxine: a comparative study with paroxetine and desipramine. British Journal of Pharmacology. 125: 526-32. PMID 9806336 DOI: 10.1038/Sj.Bjp.0702074  0.523
1998 Haddjeri N, Seletti B, Gilbert F, de Montigny C, Blier P. Effect of ergotamine on serotonin-mediated responses in the rodent and human brain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 19: 365-80. PMID 9778659 DOI: 10.1016/S0893-133X(98)00038-4  0.544
1998 Blier P, de Montigny C. Possible serotonergic mechanisms underlying the antidepressant and anti-obsessive-compulsive disorder responses. Biological Psychiatry. 44: 313-23. PMID 9755353 DOI: 10.1016/S0006-3223(98)00114-0  0.496
1998 Rueter LE, Kasamo K, de Montigny C, Blier P. Effect of long-term administration of duloxetine on the function of serotonin and noradrenaline terminals in the rat brain. Naunyn-Schmiedeberg's Archives of Pharmacology. 357: 600-10. PMID 9686935 DOI: 10.1007/PL00005214  0.413
1998 Rueter LE, de Montigny C, Blier P. In vivo electrophysiological assessment of the agonistic properties of flibanserin at pre- and postsynaptic 5-HT1A receptors in the rat brain. Synapse (New York, N.Y.). 29: 392-405. PMID 9661257 DOI: 10.1002/(Sici)1098-2396(199808)29:4<392::Aid-Syn11>3.0.Co;2-T  0.448
1998 Haddjeri N, De Montigny C, Curet O, Blier P. Effect of the reversible monoamine oxidase-A inhibitor befloxatone on the rat 5-hydroxytryptamine neurotransmission. European Journal of Pharmacology. 343: 179-92. PMID 9570466 DOI: 10.1016/S0014-2999(97)01552-5  0.573
1998 Haddjeri N, Blier P, de Montigny C. Long-Term Antidepressant Treatments Result in a Tonic Activation of Forebrain 5-HT1AReceptors The Journal of Neuroscience. 18: 10150-10156. DOI: 10.1523/Jneurosci.18-23-10150.1998  0.52
1998 de Montigny C, Blier P. Augmentation strategies in treatment resistant depression: Preclinical and clinical aspects European Psychiatry. 13: 207S-207S. DOI: 10.1016/S0924-9338(99)80272-7  0.302
1998 Blier P, Bergqvist P, El Mansari M. 257. Neurobiological basis for the pharmacotherapy of OCD Biological Psychiatry. 43: S77. DOI: 10.1016/S0006-3223(98)90705-3  0.301
1997 Blier P, Bergeron R. Early onset of therapeutic action in depression and greater efficacy of antidepressant treatments: are they related? International Clinical Psychopharmacology. S21-8. PMID 9347389 DOI: 10.1097/00004850-199707003-00004  0.365
1997 Dong J, de Montigny C, Blier P. Effect of acute and repeated versus sustained administration of the 5-HT1A receptor agonist ipsapirone: electrophysiological studies in the rat hippocampus and dorsal raphe. Naunyn-Schmiedeberg's Archives of Pharmacology. 356: 303-11. PMID 9303566 DOI: 10.1007/Pl00005055  0.575
1997 el Mansari M, Blier P. In vivo electrophysiological characterization of 5-HT receptors in the guinea pig head of caudate nucleus and orbitofrontal cortex. Neuropharmacology. 36: 577-88. PMID 9225283 DOI: 10.1016/S0028-3908(97)00035-X  0.508
1997 Mongeau R, Blier P, Montigny Cd. The serotonergic and noradrenergic systems of the hippocampus: their interactions and the effects of antidepressant treatments Brain Research Reviews. 23: 145-195. PMID 9164669 DOI: 10.1016/S0165-0173(96)00017-3  0.372
1997 Haddjeri N, de Montigny C, Blier P. Modulation of the firing activity of noradrenergic neurones in the rat locus coeruleus by the 5-hydroxtryptamine system. British Journal of Pharmacology. 120: 865-75. PMID 9138693 DOI: 10.1038/Sj.Bjp.0700968  0.548
1997 Blier P, Bergeron R, de Montigny C. Selective activation of postsynaptic 5-HT1A receptors induces rapid antidepressant response. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 16: 333-8. PMID 9109104 DOI: 10.1016/S0893-133X(96)00242-4  0.524
1997 Leyton M, Young SN, Blier P, Ellenbogen MA, Palmour RM, Ghadirian AM, Benkelfat C. The effect of tryptophan depletion on mood in medication-free, former patients with major affective disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 16: 294-7. PMID 9094147 DOI: 10.1016/S0893-133X(96)00262-X  0.33
1997 Haddjeri N, Blier P, de Montigny C. Effects of long-term treatment with the alpha 2-adrenoceptor antagonist mirtazapine on 5-HT neurotransmission. Naunyn-Schmiedeberg's Archives of Pharmacology. 355: 20-9. PMID 9007838 DOI: 10.1007/Pl00004913  0.55
1997 Haddjeri N, Blier P, de Montigny C. Noradrenergic modulation of central serotonergic neurotransmission: acute and long-term actions of mirtazapine. International Clinical Psychopharmacology. 11-7. PMID 8930005 DOI: 10.1097/00004850-199512004-00003  0.431
1997 el Mansari M, Blier P. Functional characterization of 5-HT1D autoreceptors on the modulation of 5-HT release in guinea-pig mesencephalic raphe, hippocampus and frontal cortex. British Journal of Pharmacology. 118: 681-9. PMID 8762094 DOI: 10.1111/J.1476-5381.1996.Tb15454.X  0.522
1997 Blier P, El Mansari M. Relevance to obsessive compulsive disorder of the modification of 5-HT transmission in the orbitofrontal cortex by SSRI Biological Psychiatry. 42: 139S. DOI: 10.1016/S0006-3223(97)87467-7  0.424
1997 Blier P, Haddjeri N, de Montigny C. Enhancement of 5-HT transmission by sustained administration of the reversible and selective MAO-A inhibitor befloxatone Biological Psychiatry. 42: 67S. DOI: 10.1016/S0006-3223(97)87152-1  0.372
1996 Romero L, Bel N, Artigas F, de Montigny C, Blier P. Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 15: 349-60. PMID 8887989 DOI: 10.1016/0893-133X(95)00240-E  0.579
1996 Artigas F, Romero L, de Montigny C, Blier P. Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists. Trends in Neurosciences. 19: 378-83. PMID 8873352 DOI: 10.1016/S0166-2236(96)10037-0  0.557
1996 Blier P, de Montigny C. Clarifications on the effects of 5-HT1A agonists and selective 5-HT reuptake inhibitors on the 5-HT system. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 15: 213-6. PMID 8840358 DOI: 10.1016/0893-133X(96)00092-9  0.494
1996 Piñeyro G, de Montigny C, Weiss M, Blier P. Autoregulatory properties of dorsal raphe 5-HT neurons: possible role of electrotonic coupling and 5-HT1D receptors in the rat brain. Synapse (New York, N.Y.). 22: 54-62. PMID 8822478 DOI: 10.1002/(Sici)1098-2396(199601)22:1<54::Aid-Syn6>3.0.Co;2-H  0.557
1996 Blier P, Bergeron R. Sequential administration of augmentation strategies in treatment-resistant obsessive-compulsive disorder: preliminary findings. International Clinical Psychopharmacology. 11: 37-44. PMID 8732312 DOI: 10.1097/00004850-199603000-00005  0.396
1996 Abbott FV, Hong Y, Blier P. Activation of 5-HT2A receptors potentiates pain produced by inflammatory mediators. Neuropharmacology. 35: 99-110. PMID 8684602 DOI: 10.1016/0028-3908(95)00136-0  0.488
1996 Piñeyro G, de Montigny C, Blier P. 5-HT1D receptors regulate 5-HT release in the rat raphe nuclei. In vivo voltammetry and in vitro superfusion studies. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 13: 249-60. PMID 8602897 DOI: 10.1016/0893-133X(95)00109-Q  0.53
1996 Seletti B, Benkelfat C, Blier P, Annable L, Gilbert F, de Montigny C. Serotonin1A receptor activation by flesinoxan in humans. Body temperature and neuroendocrine responses. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 13: 93-104. PMID 8597527 DOI: 10.1016/0893-133X(95)00025-9  0.377
1996 el Mansari M, Bouchard C, Blier P. Alteration of serotonin release in the guinea pig orbito-frontal cortex by selective serotonin reuptake inhibitors. Relevance to treatment of obsessive-compulsive disorder. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 13: 117-27. PMID 8597523 DOI: 10.1016/0893-133X(95)00045-F  0.497
1996 Blier P, EI Mansari M, Ducharme V, Bouchard C. Role of the terminal 5-HT autoreceptor in the orbitofrontal cortex in the mechanism of action of 5-HT reuptake inhibitors in obsessive compulsive disorder European Neuropsychopharmacology. 6: 91. DOI: 10.1016/0924-977X(96)87719-4  0.376
1996 Piñeyro G, Hen R, Blier P. Multiple 5-HT receptor subtypes regulate [3H]5-HT release in terminal projection areas: Superfusion studies in rat and mice brain European Neuropsychopharmacology. 6: 51. DOI: 10.1016/0924-977X(96)87536-5  0.474
1996 Blier P, Bergeron R, de Montigny C. Present and future tools to improve the antidepressant response based on the differential properties of 5-HT receptor subtypes European Neuropsychopharmacology. 6: 17. DOI: 10.1016/0924-977X(96)87375-5  0.361
1995 Piñeyro G, Castanon N, Hen R, Blier P. Regulation of [3H]5-HT release in raphe, frontal cortex and hippocampus of 5-HT1B knock-out mice. Neuroreport. 7: 353-9. PMID 8742487 DOI: 10.1097/00001756-199512000-00084  0.473
1995 Hadrava V, Blier P, Dennis T, Ortemann C, de Montigny C. Characterization of 5-hydroxytryptamine1A properties of flesinoxan: in vivo electrophysiology and hypothermia study. Neuropharmacology. 34: 1311-26. PMID 8570029 DOI: 10.1016/0028-3908(95)00098-Q  0.539
1995 Blier P, Bergeron R. The safety of concomitant use of sumatriptan and antidepressant treatments. Journal of Clinical Psychopharmacology. 15: 106-9. PMID 7782482 DOI: 10.1097/00004714-199504000-00005  0.377
1995 Piñeyro G, Deveault L, de Montigny C, Blier P. Effect of prolonged administration of tianeptine on 5-HT neurotransmission: an electrophysiological study in the rat hippocampus and dorsal raphe. Naunyn-Schmiedeberg's Archives of Pharmacology. 351: 119-25. PMID 7770094 DOI: 10.1007/Bf00169325  0.566
1995 Piñeyro G, Deveault L, Blier P, Dennis T, de Montigny C. Effect of acute and prolonged tianeptine administration on the 5-HT transporter: electrophysiological, biochemical and radioligand binding studies in the rat brain. Naunyn-Schmiedeberg's Archives of Pharmacology. 351: 111-8. PMID 7770093 DOI: 10.1007/Bf00169324  0.544
1995 Mongeau R, De Montigny C, Blier P. Effect of long-term administration of antidepressant drugs on the 5-HT3 receptors that enhance the electrically evoked release of [3H]noradrenaline in the rat hippocampus. European Journal of Pharmacology. 271: 121-9. PMID 7698195 DOI: 10.1016/0014-2999(94)90272-0  0.505
1995 Blier P, Bergeron R. Effectiveness of pindolol with selected antidepressant drugs in the treatment of major depression. Journal of Clinical Psychopharmacology. 15: 217-22. PMID 7636000 DOI: 10.1097/00004714-199506000-00011  0.385
1995 Haddjeri N, Blier P. Pre- and post-synaptic effects of the 5-HT3 agonist 2-methyl-5-HT on the 5-HT system in the rat brain. Synapse (New York, N.Y.). 20: 54-67. PMID 7624830 DOI: 10.1002/Syn.890200109  0.532
1995 de Montigny C, Haddjeri N, Mongeau R, Blier P. The Effects of Mirtazapine on the Interactions between Central Noradrenergic and Serotonergic Systems Cns Drugs. 4: 13-17. DOI: 10.2165/00023210-199500041-00004  0.414
1995 Bergeron R, de Montigny C, Blier P. P-2-11 A rapid antidepressant response may be induced by selectively activating postsynaptic serotonin1a receptors European Neuropsychopharmacology. 5: 277-278. DOI: 10.1016/0924-977X(95)90376-O  0.349
1994 Mongeau R, de Montigny C, Blier P. Electrophysiologic evidence for desensitization of alpha 2-adrenoceptors on serotonin terminals following long-term treatment with drugs increasing norepinephrine synaptic concentration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 10: 41-51. PMID 8179793 DOI: 10.1038/Npp.1994.6  0.518
1994 Mongeau R, De Montigny C, Blier P. Activation of 5-HT3 receptors enhances the electrically evoked release of [3H]noradrenaline in rat brain limbic structures. European Journal of Pharmacology. 256: 269-79. PMID 8045271 DOI: 10.1016/0014-2999(94)90552-5  0.502
1994 Bergeron R, Blier P. Cisapride for the treatment of nausea produced by selective serotonin reuptake inhibitors. The American Journal of Psychiatry. 151: 1084-6. PMID 8010370 DOI: 10.1176/ajp.151.7.1084  0.31
1994 Hadrava V, Blier P, de Montigny C. Agonist occupation of serotonin1A receptors in the rat hippocampus prevents their inactivation by pertussis toxin. Neuroscience. 61: 21-30. PMID 7969892 DOI: 10.1016/0306-4522(94)90056-6  0.459
1994 Blier P, de Montigny C. Current advances and trends in the treatment of depression. Trends in Pharmacological Sciences. 15: 220-6. PMID 7940983 DOI: 10.1016/0165-6147(94)90315-8  0.337
1994 Blier P, Bouchard C. Modulation of 5-HT release in the guinea-pig brain following long-term adminstration of antidepressant drugs British Journal of Pharmacology. 113: 485-495. PMID 7834200 DOI: 10.1111/J.1476-5381.1994.Tb17015.X  0.513
1994 Pineyro G, Blier P, Dennis T, de Montigny C. Desensitization of the neuronal 5-HT carrier following its long-term blockade The Journal of Neuroscience. 14: 3036-3047. DOI: 10.1523/Jneurosci.14-05-03036.1994  0.542
1993 Blier P, Bouchard C. Functional characterization of a 5-HT3 receptor which modulates the release of 5-HT in the guinea-pig brain British Journal of Pharmacology. 108: 13-22. PMID 8428202 DOI: 10.1111/J.1476-5381.1993.Tb13433.X  0.497
1993 Mongeau R, Blier P, de Montigny C. In vivo electrophysiological evidence for tonic activation by endogenous noradrenaline of alpha 2-adrenoceptors on 5-hydroxytryptamine terminals in the rat hippocampus. Naunyn-Schmiedeberg's Archives of Pharmacology. 347: 266-72. PMID 8097564 DOI: 10.1007/Bf00167444  0.467
1993 Blier P, Monroe PJ, Bouchard C, Smith DL, Smith DJ. 5-HT3 receptors which modulate [3H]5-HT release in the guinea pig hypothalamus are not autoreceptors Synapse. 15: 143-148. PMID 7505063 DOI: 10.1002/Syn.890150206  0.492
1993 Curet O, De Montigny C, Blier P. Effect of desipramine and amphetamine on noradrenergic neurotransmission: electrophysiological studies in the rat brain. European Journal of Pharmacology. 221: 59-70. PMID 1333978 DOI: 10.1016/0014-2999(92)90772-V  0.425
1993 Benkelfat C, Blier P, Seletti B, Gilbert F, de Montigny C. Neuroendocrine and hypothermic effects of intravenous injection of the selective 5-HT1A receptor agonist flesinoxan in humans European Neuropsychopharmacology. 3: 375-376. DOI: 10.1016/0924-977X(93)90164-H  0.344
1993 Blier P. Modulation of 5-HT neurotransmission by 5-HT1D receptors: possible therapeutic relevance European Neuropsychopharmacology. 3: 303-305. DOI: 10.1016/0924-977X(93)90086-2  0.486
1992 Blier P, de Montigny C. Lack of efficacy of lithium augmentation in obsessive-compulsive disorder: the perspective of different regional effects of lithium on serotonin release in the central nervous system. Journal of Clinical Psychopharmacology. 12: 65-6. PMID 1552042 DOI: 10.1097/00001573-199202000-00023  0.347
1992 Blier P, Bouchard C. Effect of repeated electroconvulsive shocks on serotonergic neurons European Journal of Pharmacology. 211: 365-373. PMID 1535597 DOI: 10.1016/0014-2999(92)90394-J  0.548
1992 Blier P, de Montigny C. Electrophysiological studies on the heterogeneity of 5-HT1A receptors: psychopharmacological implications. Clinical Neuropharmacology. 137A-138A. PMID 1498783 DOI: 10.1097/00002826-199201001-00074  0.34
1992 Galzin AM, Poirier MF, Lista A, Chodkiewicz JP, Blier P, Ramdine R, Loô H, Roux FX, Redondo A, Langer SZ. Characterization of the 5-hydroxytryptamine receptor modulating the release of 5-[3H]hydroxytryptamine in slices of the human neocortex. Journal of Neurochemistry. 59: 1293-301. PMID 1357094 DOI: 10.1111/J.1471-4159.1992.Tb08440.X  0.494
1992 de Montigny C, Blier P. Potentiation of 5-HT neurotransmission by short-term lithium: in vivo electrophysiological studies. Clinical Neuropharmacology. 610A-611A. PMID 1323408 DOI: 10.1097/00002826-199201001-00316  0.467
1992 DE Montigny C, Pineyro G, Chaput Y, Blier P. Electrophysiological studies on the effect of long-term 5-HT reuptake inhibition on the function of 5-HT neurons. Clinical Neuropharmacology. 440A-441A. PMID 1323401 DOI: 10.1097/00002826-199201001-00230  0.423
1991 de Montigny C, Blier P. Desensitization of terminal 5-HT autoreceptors by 5-HT reuptake blockers. Archives of General Psychiatry. 48: 483-4. PMID 2021304 DOI: 10.1001/Archpsyc.1991.01810290095019  0.512
1991 Lista A, Blier P, de Montigny C. Benzodiazepine receptors modulating serotonergic neurotransmission in rat hippocampus do not desensitize after long-term diazepam treatment. Brain Research. 526: 161-4. PMID 1964107 DOI: 10.1016/0006-8993(90)90265-D  0.52
1991 Blier P. Terminal serotonin autoreceptor function in the rat hippocampus is not modified by pertussis and cholera toxins. Naunyn-Schmiedeberg's Archives of Pharmacology. 344: 160-6. PMID 1944610 DOI: 10.1007/Bf00167213  0.495
1991 Blier P, Curet O, Chaput Y, de Montigny C. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--II. Effects of acute administration of 1-PP and long-term administration of tandospirone on noradrenergic neurotransmission. Neuropharmacology. 30: 691-701. PMID 1681447 DOI: 10.1016/0028-3908(91)90176-C  0.458
1991 Godbout R, Chaput Y, Blier P, de Montigny C. Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine--I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission. Neuropharmacology. 30: 679-90. PMID 1681446 DOI: 10.1016/0028-3908(91)90175-B  0.584
1991 Bouthillier A, Blier P, de Montigny C. Flerobuterol, a beta-adrenoceptor agonist, enhances serotonergic neurotransmission: an electrophysiological study in the rat brain. Psychopharmacology. 103: 357-65. PMID 1676181 DOI: 10.1007/Bf02244290  0.574
1990 Lista A, Blier P, De Montigny C. In vivo presynaptic modulation of serotonergic neurotransmission in the rat hippocampus by diazepam. European Journal of Pharmacology. 171: 229-31. PMID 2559857 DOI: 10.1016/0014-2999(89)90111-8  0.55
1990 Lista A, Blier P, De Montigny C. The benzodiazepine receptor inverse agonist DMCM decreases serotonergic transmission in rat hippocampus: an in vivo electrophysiological study. Synapse (New York, N.Y.). 6: 175-8. PMID 2173164 DOI: 10.1002/Syn.890060209  0.493
1990 Blier P, Serrano A, Scatton B. Differential responsiveness of the rat dorsal and median raphe 5-HT systems to 5-HT1 receptor agonists and p-chloroamphetamine. Synapse. 5: 120-133. PMID 2137943 DOI: 10.1002/Syn.890050206  0.537
1990 Blier P, de Montigny C. Differential effect of gepirone on presynaptic and postsynaptic serotonin receptors: single-cell recording studies. Journal of Clinical Psychopharmacology. 10: 13S-20S. PMID 1973935 DOI: 10.1097/00004714-199006001-00004  0.572
1990 LISTA A, BLIER P, MONTIGNY C. GABAA-Benzodiazepine Receptors Modulate Serotonin Release: In Vivo Electrophysiological Studies in the Rat Hippocampus Annals of the New York Academy of Sciences. 604: 622-625. DOI: 10.1111/J.1749-6632.1990.Tb32044.X  0.408
1990 Blier P, de Montigny C. Electrophysiological Investigation of the Adaptive Response of the 5-HT System to the Administration of 5-HT1A Receptor Agonists Journal of Cardiovascular Pharmacology. 15: S42-S48. DOI: 10.1097/00005344-199000157-00006  0.577
1989 Blier P, Galzin AM, Langer SZ. Diurnal variation in the function of serotonin terminals in the rat hypothalamus. Journal of Neurochemistry. 52: 453-9. PMID 2911025 DOI: 10.1111/J.1471-4159.1989.Tb09142.X  0.494
1989 Blier P, de Montigny C. Modification of 5-HT neuron properties by sustained administration of the 5-HT1A agonist gepirone: electrophysiological studies in the rat brain. Synapse (New York, N.Y.). 1: 470-80. PMID 2905533 DOI: 10.1002/syn.890010511  0.495
1989 Blier P, Ramdine R, Galzin AM, Langer SZ. Frequency-dependence of serotonin autoreceptor but not alpha 2-adrenoceptor inhibition of [3H]-serotonin release in rat hypothalamic slices. Naunyn-Schmiedeberg's Archives of Pharmacology. 339: 60-4. PMID 2566927 DOI: 10.1007/Bf00165127  0.477
1989 Blier P, Steinberg S, Chaput Y, de Montigny C. Electrophysiological assessment of putative antagonists of 5-hydroxytryptamine receptors: a single-cell study in the rat dorsal raphe nucleus. Canadian Journal of Physiology and Pharmacology. 67: 98-105. PMID 2523754 DOI: 10.1139/Y89-017  0.558
1989 de Montigny C, Godbout R, Curet O, Blier P. Anxiolytic-antidepressant 5-HT1A agonists modify 5-HT neuron properties Biological Psychiatry. 25: A142-A143. DOI: 10.1016/0006-3223(89)91773-3  0.451
1988 Blier P, Chaput Y, de Montigny C. Long-term 5-HT reuptake blockade, but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: an electrophysiological study in the rat brain. Naunyn-Schmiedeberg's Archives of Pharmacology. 337: 246-54. PMID 3260661 DOI: 10.1007/Bf00168834  0.533
1987 Blier P, de Montigny C. Antidepressant monoamine oxidase inhibitors enhance serotonin but not norepinephrine neurotransmission. Psychopharmacology Series. 3: 127-34. PMID 3029752 DOI: 10.1007/978-3-642-71288-3_15  0.334
1987 Blier P, de Montigny C, Tardif D. Short-term lithium treatment enhances responsiveness of postsynaptic 5-HT1A receptors without altering 5-HT autoreceptor sensitivity: an electrophysiological study in the rat brain. Synapse (New York, N.Y.). 1: 225-32. PMID 2850622 DOI: 10.1002/syn.890010302  0.482
1987 BLIER P, de MONTIGNY C, CHAPUT Y. Modifications of the Serotonin System by Antidepressant Treatments Journal of Clinical Psychopharmacology. 7: 36S. DOI: 10.1097/00004714-198712001-00003  0.551
1986 Blier P, de Montigny C, Azzaro AJ. Effect of repeated amiflamine administration on serotonergic and noradrenergic neurotransmission: electrophysiological studies in the rat CNS. Naunyn-Schmiedeberg's Archives of Pharmacology. 334: 253-60. PMID 3808082 DOI: 10.1007/BF00508779  0.459
1986 Chaput Y, de Montigny C, Blier P. Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: electrophysiological studies in the rat brain. Naunyn-Schmiedeberg's Archives of Pharmacology. 333: 342-8. PMID 3022157 DOI: 10.1007/BF00500007  0.481
1985 de Montigny C, Blier P, Chaput Y. Electrophysiologically-identified serotonin receptors in the rat CNS. Effect of antidepressant treatment. Neuropharmacology. 23: 1511-20. PMID 6396527 DOI: 10.1016/0028-3908(84)90095-9  0.347
1985 Blier P, De Montigny C. Short-term lithium administration enhances serotonergic neurotransmission: electrophysiological evidence in the rat CNS. European Journal of Pharmacology. 113: 69-77. PMID 2995061 DOI: 10.1016/0014-2999(85)90344-9  0.471
1984 Blier P, de Montigny C, Tardif D. Effects of the two antidepressant drugs mianserin and indalpine on the serotonergic system: single-cell studies in the rat. Psychopharmacology. 84: 242-9. PMID 6438684 DOI: 10.1007/BF00427453  0.463
1981 Blier P, de Montigny C. Effect of chronic tricylic antidepressant treatment on the serotoninergic autoreceptor: a microiontophoretic study in the rat. Naunyn-Schmiedeberg's Archives of Pharmacology. 314: 123-8. PMID 7453831 DOI: 10.1007/bf00504527  0.481
1981 de Montigny C, Blier P, Caillé G, Kouassi E. Pre- and postsynaptic effects of zimelidine and norzimelidine on the serotoninergic system: single cell studies in the rat. Acta Psychiatrica Scandinavica. Supplementum. 290: 79-90. PMID 6452807 DOI: 10.1111/J.1600-0447.1981.Tb00711.X  0.488
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