Zachary A. Knight - Publications

Affiliations: 
University of California, San Francisco, San Francisco, CA 

61 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bai L, Mesgarzadeh S, Ramesh KS, Huey EL, Liu Y, Gray LA, Aitken TJ, Chen Y, Beutler LR, Ahn JS, Madisen L, Zeng H, Krasnow MA, Knight ZA. Genetic Identification of Vagal Sensory Neurons That Control Feeding. Cell. 179: 1129-1143.e23. PMID 31730854 DOI: 10.1016/j.cell.2019.10.031  1
2019 Chen Y, Essner RA, Kosar S, Miller OH, Lin YC, Mesgarzadeh S, Knight ZA. Sustained NPY signaling enables AgRP neurons to drive feeding. Elife. 8. PMID 31033437 DOI: 10.7554/eLife.46348  1
2019 Zimmerman CA, Huey EL, Ahn JS, Beutler LR, Tan CL, Kosar S, Bai L, Chen Y, Corpuz TV, Madisen L, Zeng H, Knight ZA. A gut-to-brain signal of fluid osmolarity controls thirst satiation. Nature. PMID 30918408 DOI: 10.1038/s41586-019-1066-x  1
2018 Tan CL, Knight ZA. Regulation of Body Temperature by the Nervous System. Neuron. 98: 31-48. PMID 29621489 DOI: 10.1016/j.neuron.2018.02.022  1
2018 Beutler LR, Knight ZA. A Spotlight on Appetite. Neuron. 97: 739-741. PMID 29470967 DOI: 10.1016/j.neuron.2018.01.050  1
2017 Leib DE, Zimmerman CA, Poormoghaddam A, Huey EL, Ahn JS, Lin YC, Tan CL, Chen Y, Knight ZA. The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement. Neuron. 96: 1272-1281.e4. PMID 29268095 DOI: 10.1016/j.neuron.2017.11.041  1
2017 Garrison JL, Knight ZA. Linking smell to metabolism and aging. Science (New York, N.Y.). 358: 718-719. PMID 29123049 DOI: 10.1126/science.aao5474  0.28
2017 Beutler LR, Chen Y, Ahn JS, Lin YC, Essner RA, Knight ZA. Dynamics of Gut-Brain Communication Underlying Hunger. Neuron. 96: 461-475.e5. PMID 29024666 DOI: 10.1016/j.neuron.2017.09.043  1
2017 Zimmerman CA, Leib DE, Knight ZA. Neural circuits underlying thirst and fluid homeostasis. Nature Reviews. Neuroscience. PMID 28638120 DOI: 10.1038/nrn.2017.71  1
2017 Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. The Journal of Clinical Investigation. 127: 2438. PMID 28569734 DOI: 10.1172/JCI95182  1
2017 Chung S, Weber F, Zhong P, Tan CL, Nguyen TN, Beier KT, Hörmann N, Chang WC, Zhang Z, Do JP, Yao S, Krashes MJ, Tasic B, Cetin A, Zeng H, ... Knight ZA, et al. Identification of preoptic sleep neurons using retrograde labelling and gene profiling. Nature. PMID 28514446 DOI: 10.1038/nature22350  1
2016 Leib DE, Zimmerman CA, Knight ZA. Thirst. Current Biology : Cb. 26: R1260-R1265. PMID 27997832 DOI: 10.1016/j.cub.2016.11.019  1
2016 Tan CL, Cooke EK, Leib DE, Lin YC, Daly GE, Zimmerman CA, Knight ZA. Warm-Sensitive Neurons that Control Body Temperature. Cell. PMID 27616062 DOI: 10.1016/j.cell.2016.08.028  1
2016 Leib DE, Knight ZA. Rapid Sensing of Dietary Amino Acid Deficiency Does Not Require GCN2. Cell Reports. 16: 2051-2. PMID 27558825 DOI: 10.1016/j.celrep.2016.08.022  1
2016 Chen Y, Lin YC, Zimmerman C, Essner RA, Knight ZA. Hunger neurons drive feeding through a sustained, positive reinforcement signal. Elife. 5. PMID 27554486 DOI: 10.7554/eLife.18640  1
2016 Zimmerman CA, Lin YC, Leib DE, Guo L, Huey EL, Daly GE, Chen Y, Knight ZA. Thirst neurons anticipate the homeostatic consequences of eating and drinking. Nature. PMID 27487211 DOI: 10.1038/nature18950  1
2016 Chen Y, Knight ZA. Making sense of the sensory regulation of hunger neurons. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 38: 316-24. PMID 26898524 DOI: 10.1002/bies.201500167  1
2015 Leib DE, Knight ZA. Re-examination of Dietary Amino Acid Sensing Reveals a GCN2-Independent Mechanism. Cell Reports. 13: 1081-9. PMID 26526991 DOI: 10.1016/j.celrep.2015.09.055  1
2015 Chen Y, Lin YC, Kuo TW, Knight ZA. Sensory detection of food rapidly modulates arcuate feeding circuits. Cell. 160: 829-41. PMID 25703096 DOI: 10.1016/j.cell.2015.01.033  1
2015 Cage TA, Chanthery Y, Chesler L, Grimmer M, Knight Z, Shokat K, Weiss WA, Gustafson WC. Downregulation of MYCN through PI3K inhibition in mouse models of pediatric neural cancer Frontiers in Oncology. 5. DOI: 10.3389/fonc.2015.00111  1
2014 Tan K, Knight ZA, Friedman JM. Ablation of AgRP neurons impairs adaption to restricted feeding. Molecular Metabolism. 3: 694-704. PMID 25352998 DOI: 10.1016/j.molmet.2014.07.002  0.88
2014 Knight ZA, Schmidt SF, Birsoy K, Tan K, Friedman JM. A critical role for mTORC1 in erythropoiesis and anemia. Elife. 3: e01913. PMID 25201874 DOI: 10.7554/eLife.01913  0.88
2014 Ekstrand MI, Nectow AR, Knight ZA, Latcha KN, Pomeranz LE, Friedman JM. Molecular profiling of neurons based on connectivity. Cell. 157: 1230-42. PMID 24855954 DOI: 10.1016/j.cell.2014.03.059  0.88
2012 Knight ZA, Tan K, Birsoy K, Schmidt S, Garrison JL, Wysocki RW, Emiliano A, Ekstrand MI, Friedman JM. Molecular profiling of activated neurons by phosphorylated ribosome capture. Cell. 151: 1126-37. PMID 23178128 DOI: 10.1016/j.cell.2012.10.039  1
2010 Knight ZA, Hannan KS, Greenberg ML, Friedman JM. Hyperleptinemia is required for the development of leptin resistance. Plos One. 5: e11376. PMID 20613882 DOI: 10.1371/journal.pone.0011376  0.88
2010 Williams O, Houseman BT, Kunkel EJ, Aizenstein B, Hoffman R, Knight ZA, Shokat KM. Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs. Chemistry & Biology. 17: 123-34. PMID 20189103 DOI: 10.1016/j.chembiol.2010.01.010  1
2010 Knight ZA, Lin H, Shokat KM. Targeting the cancer kinome through polypharmacology. Nature Reviews. Cancer. 10: 130-7. PMID 20094047 DOI: 10.1038/nrc2787  1
2009 Niedermeier M, Hennessy BT, Knight ZA, Henneberg M, Hu J, Kurtova AV, Wierda WG, Keating MJ, Shokat KM, Burger JA. Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood. 113: 5549-57. PMID 19318683 DOI: 10.1182/blood-2008-06-165068  1
2009 Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, Shokat KM. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. Plos Biology. 7: e38. PMID 19209957 DOI: 10.1371/journal.pbio.1000038  1
2009 Fan QW, Cheng C, Knight ZA, Haas-Kogan D, Stokoe D, James CD, McCormick F, Shokat KM, Weiss WA. EGFR signals to mTOR through PKC and independently of Akt in glioma. Science Signaling. 2: ra4. PMID 19176518 DOI: 10.1126/scisignal.2000014  1
2009 Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, et al. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Research. 69: 565-72. PMID 19147570 DOI: 10.1158/0008-5472.CAN-08-3389  1
2008 Zhang TT, Okkenhaug K, Nashed BF, Puri KD, Knight ZA, Shokat KM, Vanhaesebroeck B, Marshall AJ. Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production. The Journal of Allergy and Clinical Immunology. 122: 811-819.e2. PMID 19014771 DOI: 10.1016/j.jaci.2008.08.008  1
2008 Chaisuparat R, Hu J, Jham BC, Knight ZA, Shokat KM, Montaner S. Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma. Cancer Research. 68: 8361-8. PMID 18922908 DOI: 10.1158/0008-5472.CAN-08-0878  1
2008 Apsel B, Blair JA, Gonzalez B, Nazif TM, Feldman ME, Aizenstein B, Hoffman R, Williams RL, Shokat KM, Knight ZA. Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nature Chemical Biology. 4: 691-9. PMID 18849971 DOI: 10.1038/nchembio.117  1
2008 Oda K, Okada J, Timmerman L, Rodriguez-Viciana P, Stokoe D, Shoji K, Taketani Y, Kuramoto H, Knight ZA, Shokat KM, McCormick F. PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation. Cancer Research. 68: 8127-36. PMID 18829572 DOI: 10.1158/0008-5472.CAN-08-0755  1
2008 Kharas MG, Janes MR, Scarfone VM, Lilly MB, Knight ZA, Shokat KM, Fruman DA. Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. The Journal of Clinical Investigation. 118: 3038-50. PMID 18704194 DOI: 10.1172/JCI33337  1
2008 Zunder ER, Knight ZA, Houseman BT, Apsel B, Shokat KM. Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha. Cancer Cell. 14: 180-92. PMID 18691552 DOI: 10.1016/j.ccr.2008.06.014  1
2008 Wang J, Knight ZA, Fiedler D, Williams O, Shokat KM, Pearce D. Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport. American Journal of Physiology. Renal Physiology. 295: F843-50. PMID 18653476 DOI: 10.1152/ajprenal.90348.2008  1
2008 Park S, Chapuis N, Bardet V, Tamburini J, Gallay N, Willems L, Knight ZA, Shokat KM, Azar N, Viguié F, Ifrah N, Dreyfus F, Mayeux P, Lacombe C, Bouscary D. PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML. Leukemia. 22: 1698-706. PMID 18548104 DOI: 10.1038/leu.2008.144  1
2008 Sauer S, Bruno L, Hertweck A, Finlay D, Leleu M, Spivakov M, Knight ZA, Cobb BS, Cantrell D, O'Connor E, Shokat KM, Fisher AG, Merkenschlager M. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proceedings of the National Academy of Sciences of the United States of America. 105: 7797-802. PMID 18509048 DOI: 10.1073/pnas.0800928105  1
2008 Torbett NE, Luna-Moran A, Knight ZA, Houk A, Moasser M, Weiss W, Shokat KM, Stokoe D. A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. The Biochemical Journal. 415: 97-110. PMID 18498248 DOI: 10.1042/BJ20080639  1
2008 Chen JS, Zhou LJ, Entin-Meer M, Yang X, Donker M, Knight ZA, Weiss W, Shokat KM, Haas-Kogan D, Stokoe D. Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Molecular Cancer Therapeutics. 7: 841-50. PMID 18413797 DOI: 10.1158/1535-7163.MCT-07-0393  1
2008 Balla A, Tuymetova G, Toth B, Szentpetery Z, Zhao X, Knight ZA, Shokat K, Steinbach PJ, Balla T. Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling. Biochemistry. 47: 1599-607. PMID 18205404 DOI: 10.1021/bi7017927  0.4
2008 Balla A, Kim YJ, Varnai P, Szentpetery Z, Knight Z, Shokat KM, Balla T. Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha. Molecular Biology of the Cell. 19: 711-21. PMID 18077555 DOI: 10.1091/mbc.E07-07-0713  1
2007 Hung CH, Thomas L, Ruby CE, Atkins KM, Morris NP, Knight ZA, Scholz I, Barklis E, Weinberg AD, Shokat KM, Thomas G. HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I. Cell Host & Microbe. 1: 121-33. PMID 18005690 DOI: 10.1016/j.chom.2007.03.004  1
2007 Knight ZA, Feldman ME, Balla A, Balla T, Shokat KM. A membrane capture assay for lipid kinase activity. Nature Protocols. 2: 2459-66. PMID 17947987 DOI: 10.1038/nprot.2007.361  1
2007 Fan QW, Cheng CK, Nicolaides TP, Hackett CS, Knight ZA, Shokat KM, Weiss WA. A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma. Cancer Research. 67: 7960-5. PMID 17804702 DOI: 10.1158/0008-5472.CAN-07-2154  1
2007 Knight ZA, Garrison JL, Chan K, King DS, Shokat KM. A remodelled protease that cleaves phosphotyrosine substrates. Journal of the American Chemical Society. 129: 11672-3. PMID 17803306 DOI: 10.1021/ja073875n  1
2007 Knight ZA, Shokat KM. Chemically targeting the PI3K family. Biochemical Society Transactions. 35: 245-9. PMID 17371250 DOI: 10.1042/BST0350245  1
2007 Knight ZA, Shokat KM. Chemical genetics: where genetics and pharmacology meet. Cell. 128: 425-30. PMID 17289560 DOI: 10.1016/j.cell.2007.01.021  1
2006 Tóth B, Balla A, Ma H, Knight ZA, Shokat KM, Balla T. Phosphatidylinositol 4-kinase IIIbeta regulates the transport of ceramide between the endoplasmic reticulum and Golgi. The Journal of Biological Chemistry. 281: 36369-77. PMID 17003043 DOI: 10.1074/jbc.M604935200  1
2006 Van Keymeulen A, Wong K, Knight ZA, Govaerts C, Hahn KM, Shokat KM, Bourne HR. To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. The Journal of Cell Biology. 174: 437-45. PMID 16864657 DOI: 10.1083/jcb.200604113  1
2006 Fan QW, Knight ZA, Goldenberg DD, Yu W, Mostov KE, Stokoe D, Shokat KM, Weiss WA. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell. 9: 341-9. PMID 16697955 DOI: 10.1016/j.ccr.2006.03.029  1
2006 Sturgeon CM, Knight ZA, Shokat KM, Roberge M. Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage. Molecular Cancer Therapeutics. 5: 885-92. PMID 16648558 DOI: 10.1158/1535-7163.MCT-05-0358  1
2006 Knight ZA, Gonzalez B, Feldman ME, Zunder ER, Goldenberg DD, Williams O, Loewith R, Stokoe D, Balla A, Toth B, Balla T, Weiss WA, Williams RL, Shokat KM. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 125: 733-47. PMID 16647110 DOI: 10.1016/j.cell.2006.03.035  1
2006 Knight ZA, Shokat KM. Knock-outs and inhibitors: One and the same? Blood. 107: 420-421. DOI: 10.1182/blood-2005-10-4264  1
2005 Knight ZA, Shokat KM. Features of selective kinase inhibitors. Chemistry & Biology. 12: 621-37. PMID 15975507 DOI: 10.1016/j.chembiol.2005.04.011  1
2005 Alaimo PJ, Knight ZA, Shokat KM. Targeting the gatekeeper residue in phosphoinositide 3-kinases. Bioorganic & Medicinal Chemistry. 13: 2825-36. PMID 15781393 DOI: 10.1016/j.bmc.2005.02.021  1
2004 Knight ZA, Chiang GG, Alaimo PJ, Kenski DM, Ho CB, Coan K, Abraham RT, Shokat KM. Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold. Bioorganic & Medicinal Chemistry. 12: 4749-59. PMID 15358300 DOI: 10.1016/j.bmc.2004.06.022  1
2003 Knight ZA, Schilling B, Row RH, Kenski DM, Gibson BW, Shokat KM. Phosphospecific proteolysis for mapping sites of protein phosphorylation. Nature Biotechnology. 21: 1047-54. PMID 12923550 DOI: 10.1038/nbt863  1
2000 Knight ZA. Another possible mechanism of resistance to STI571. Blood. 96: 4003-5. PMID 11186275  1
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