Bruce Nathan Ames - Publications

Affiliations: 
Biochemistry and Molecular Biology University of California, Berkeley, Berkeley, CA, United States 
Area:
mitochondrial decay, mutagens
Website:
http://mcb.berkeley.edu/index.php?option=com_mcbfaculty&name=amesb

161 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2010 Ames BN. Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake. Journal of Nucleic Acids. 2010. PMID 20936173 DOI: 10.4061/2010/725071  0.335
2009 Agrawal AK, Suh JH, Ames BN, Vichinsky EP, Lal A. Heightened Sulfur Amino Acid Oxidation in Plasma and Erythrocytes in β-Thalassemia Major. Blood. 114: 4065-4065. DOI: 10.1182/Blood.V114.22.4065.4065  0.326
2008 Lal A, Atamna W, Killilea DW, Suh JH, Ames BN. Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts. Redox Report : Communications in Free Radical Research. 13: 2-10. PMID 18284845 DOI: 10.1179/135100008X259150  0.324
2008 Mashiyama ST, Hansen CM, Roitman E, Sarmiento S, Leklem JE, Shultz TD, Ames BN. An assay for uracil in human DNA at baseline: effect of marginal vitamin B6 deficiency. Analytical Biochemistry. 372: 21-31. PMID 17963712 DOI: 10.1016/J.Ab.2007.08.034  0.768
2008 Atamna H, Nguyen A, Schultz C, Boyle K, Newberry J, Kato H, Ames BN. Methylene blue delays cellular senescence and enhances key mitochondrial biochemical pathways. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 703-12. PMID 17928358 DOI: 10.1096/Fj.07-9610Com  0.318
2008 Morris CR, Suh JH, Hagar W, Larkin S, Bland DA, Steinberg MH, Vichinsky EP, Shigenaga M, Ames B, Kuypers FA, Klings ES. Erythrocyte glutamine depletion, altered redox environment, and pulmonary hypertension in sickle cell disease Blood. 111: 402-410. PMID 17848621 DOI: 10.1182/Blood-2007-04-081703  0.308
2008 Walter PB, Porter JB, Evans P, Kwiatkowski J, Neufeld EJ, Coates TD, Giardina P, Grady Rj, Vichinsky E, Olivieri NF, Trachtenberg F, Alberti D, Fung E, Ames B, Lui A, et al. Increased Nucleosomal DNA Fragmentation in Leukocytes of Thalassemia Patients. Blood. 112: 1868-1868. DOI: 10.1182/Blood.V112.11.1868.1868  0.338
2007 Voloboueva LA, Killilea DW, Atamna H, Ames BN. N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human retinal pigment epithelial cells from iron overload: relevance to macular degeneration. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 4077-86. PMID 17656467 DOI: 10.1096/Fj.07-8396Com  0.758
2007 Offer T, Ames BN, Bailey SW, Sabens EA, Nozawa M, Ayling JE. 5-Methyltetrahydrofolate inhibits photosensitization reactions and strand breaks in DNA. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 2101-7. PMID 17341682 DOI: 10.1096/Fj.06-7513Com  0.346
2007 Jia L, Liu Z, Sun L, Miller SS, Ames BN, Cotman CW, Liu J. Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid. Investigative Ophthalmology & Visual Science. 48: 339-48. PMID 17197552 DOI: 10.1167/Iovs.06-0248  0.334
2007 Atamna H, Newberry J, Erlitzki R, Schultz CS, Ames BN. Biotin deficiency inhibits heme synthesis and impairs mitochondria in human lung fibroblasts. The Journal of Nutrition. 137: 25-30. PMID 17182796 DOI: 10.1093/Jn/137.1.25  0.348
2007 Hansen CM, Mashiyama ST, Roitman E, Sarmiento S, Leklem JE, Shultz TD, Ames BN. Marginal vitamin B‐6 deficiency does not increase uracil concentration in lymphocyte DNA The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A346-A  0.757
2006 Ames BN. Low micronutrient intake may accelerate the degenerative diseases of aging through allocation of scarce micronutrients by triage. Proceedings of the National Academy of Sciences of the United States of America. 103: 17589-94. PMID 17101959 DOI: 10.1073/Pnas.0608757103  0.337
2006 Walter PB, Killilea DW, Fung EB, Lui A, Madden J, Porter J, Evans P, Ames BN, Vichinsky E, Harmatz P. Leukocyte Apoptosis and Inflammation in Iron-Overloaded Patients with Sickle Cell Disease or β-Thalassemia: A Mechanism for Increased Stroke and Disease Severity in Sickle Cell Disease. Blood. 108: 1233-1233. DOI: 10.1182/Blood.V108.11.1233.1233  0.304
2005 Offer T, Bhagat A, Lal A, Atamna W, Singer ST, Vichinsky EP, Kuypers FA, Ames BN. Measuring chromosome breaks in patients with thalassemia. Annals of the New York Academy of Sciences. 1054: 439-44. PMID 16339694 DOI: 10.1196/Annals.1345.050  0.358
2005 Voloboueva LA, Liu J, Suh JH, Ames BN, Miller SS. (R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage. Investigative Ophthalmology & Visual Science. 46: 4302-10. PMID 16249512 DOI: 10.1167/Iovs.04-1098  0.762
2005 Ames BN, Atamna H, Killilea DW. Mineral and vitamin deficiencies can accelerate the mitochondrial decay of aging. Molecular Aspects of Medicine. 26: 363-78. PMID 16102804 DOI: 10.1016/J.Mam.2005.07.007  0.344
2005 Ames BN. Increasing longevity by tuning up metabolism. To maximize human health and lifespan, scientists must abandon outdated models of micronutrients. Embo Reports. 6: S20-4. PMID 15995656 DOI: 10.1038/Sj.Embor.7400426  0.308
2005 Kadiiska MB, Gladen BC, Baird DD, Graham LB, Parker CE, Ames BN, Basu S, Fitzgerald GA, Lawson JA, Marnett LJ, Morrow JD, Murray DM, Plastaras J, Roberts LJ, Rokach J, et al. Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free Radical Biology & Medicine. 38: 711-8. PMID 15721981 DOI: 10.1016/J.Freeradbiomed.2004.10.024  0.303
2005 Kadiiska MB, Gladen BC, Baird DD, Germolec D, Graham LB, Parker CE, Nyska A, Wachsman JT, Ames BN, Basu S, Brot N, Fitzgerald GA, Floyd RA, George M, Heinecke JW, et al. Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radical Biology & Medicine. 38: 698-710. PMID 15721980 DOI: 10.1016/J.Freeradbiomed.2004.09.017  0.346
2005 Lal A, Bhagat A, Atamna W, Offer T, Vichinsky EP, Kuypers FA, Ames BN. Increased Chromosomal Breaks in Sickle Cell Disease as Evidenced by the Presence of Micronuclei in Erythrocytes. Blood. 106: 3807-3807. DOI: 10.1182/Blood.V106.11.3807.3807  0.35
2005 Lal A, Suh JH, Ames BN. Efficacy of Alpha-Lipoic Acid in Iron-Induced Oxidative Stress. Blood. 106: 3599-3599. DOI: 10.1182/Blood.V106.11.3599.3599  0.312
2004 Ames BN, Liu J. Delaying the mitochondrial decay of aging with acetylcarnitine. Annals of the New York Academy of Sciences. 1033: 108-16. PMID 15591008 DOI: 10.1196/Annals.1320.010  0.314
2004 Ames BN. Supplements and tuning up metabolism. The Journal of Nutrition. 134: 3164S-3168S. PMID 15514290 DOI: 10.1093/Jn/134.11.3164S  0.327
2004 Courtemanche C, Elson-Schwab I, Mashiyama ST, Kerry N, Ames BN. Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro. Journal of Immunology (Baltimore, Md. : 1950). 173: 3186-92. PMID 15322179 DOI: 10.4049/Jimmunol.173.5.3186  0.75
2004 Mashiyama ST, Courtemanche C, Elson-Schwab I, Crott J, Lee BL, Ong CN, Fenech M, Ames BN. Uracil in DNA, determined by an improved assay, is increased when deoxynucleosides are added to folate-deficient cultured human lymphocytes. Analytical Biochemistry. 330: 58-69. PMID 15183762 DOI: 10.1016/J.Ab.2004.03.065  0.773
2004 Ames BN. A role for supplements in optimizing health: the metabolic tune-up. Archives of Biochemistry and Biophysics. 423: 227-34. PMID 14989256 DOI: 10.1016/J.Abb.2003.11.002  0.38
2004 Courtemanche C, Huang AC, Elson-Schwab I, Kerry N, Ng BY, Ames BN. Folate deficiency and ionizing radiation cause DNA breaks in primary human lymphocytes: a comparison. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 209-11. PMID 14597554 DOI: 10.1096/Fj.03-0382Fje  0.344
2003 Ho E, Courtemanche C, Ames BN. Zinc deficiency induces oxidative DNA damage and increases p53 expression in human lung fibroblasts. The Journal of Nutrition. 133: 2543-8. PMID 12888634 DOI: 10.1093/Jn/133.8.2543  0.395
2003 Jiang Q, Blount BC, Ames BN. 5-Chlorouracil, a marker of DNA damage from hypochlorous acid during inflammation. A gas chromatography-mass spectrometry assay. The Journal of Biological Chemistry. 278: 32834-40. PMID 12810714 DOI: 10.1074/Jbc.M304021200  0.359
2003 Ames BN. The metabolic tune-up: metabolic harmony and disease prevention. The Journal of Nutrition. 133: 1544S-8S. PMID 12730462 DOI: 10.1093/Jn/133.5.1544S  0.386
2003 Jacob RA, Aiello GM, Stephensen CB, Blumberg JB, Milbury PE, Wallock LM, Ames BN. Moderate antioxidant supplementation has no effect on biomarkers of oxidant damage in healthy men with low fruit and vegetable intakes. The Journal of Nutrition. 133: 740-3. PMID 12612146 DOI: 10.1093/Jn/133.3.740  0.34
2003 Ames BN, Liu J, Atamna H, Hagen TM. Delaying the mitochondrial decay of aging in the brain Clinical Neuroscience Research. 2: 331-338. DOI: 10.1016/S1566-2772(03)00010-0  0.331
2002 Ho E, Ames BN. Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line. Proceedings of the National Academy of Sciences of the United States of America. 99: 16770-5. PMID 12481036 DOI: 10.1073/Pnas.222679399  0.376
2002 Jiang Q, Lykkesfeldt J, Shigenaga MK, Shigeno ET, Christen S, Ames BN. Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation. Free Radical Biology & Medicine. 33: 1534-42. PMID 12446211 DOI: 10.1016/S0891-5849(02)01091-2  0.311
2002 Atamna H, Killilea DW, Killilea AN, Ames BN. Heme deficiency may be a factor in the mitochondrial and neuronal decay of aging. Proceedings of the National Academy of Sciences of the United States of America. 99: 14807-12. PMID 12417755 DOI: 10.1073/Pnas.192585799  0.312
2002 Liu J, Atamna H, Kuratsune H, Ames BN. Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites. Annals of the New York Academy of Sciences. 959: 133-66. PMID 11976193 DOI: 10.1111/J.1749-6632.2002.Tb02090.X  0.332
2002 Ames BN, Elson-Schwab I, Silver EA. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased K(m)): relevance to genetic disease and polymorphisms. The American Journal of Clinical Nutrition. 75: 616-58. PMID 11916749 DOI: 10.1093/Ajcn/75.4.616  0.339
2002 Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proceedings of the National Academy of Sciences of the United States of America. 99: 2356-61. PMID 11854529 DOI: 10.1073/Pnas.261709299  0.306
2002 Liu J, Killilea DW, Ames BN. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid. Proceedings of the National Academy of Sciences of the United States of America. 99: 1876-81. PMID 11854488 DOI: 10.1073/Pnas.261709098  0.302
2002 Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 99: 1870-5. PMID 11854487 DOI: 10.1073/Pnas.261708898  0.307
2001 Ames BN, Liu J, Atamna H. Delaying Aging with Mitochondrial Micronutrients and Antioxidants. Thescientificworldjournal. 1: 81-82. PMID 30147555 DOI: 10.1100/Tsw.2001.113  0.325
2001 Atamna H, Liu J, Ames BN. Heme deficiency selectively interrupts assembly of mitochondrial complex IV in human fibroblasts: revelance to aging. The Journal of Biological Chemistry. 276: 48410-6. PMID 11598132 DOI: 10.1074/Jbc.M108362200  0.303
2001 Crott JW, Mashiyama ST, Ames BN, Fenech M. The effect of folic acid deficiency and MTHFR C677T polymorphism on chromosome damage in human lymphocytes in vitro. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 10: 1089-96. PMID 11588136  0.743
2001 Crott JW, Mashiyama ST, Ames BN, Fenech MF. Methylenetetrahydrofolate reductase C677T polymorphism does not alter folic acid deficiency-induced uracil incorporation into primary human lymphocyte DNA in vitro. Carcinogenesis. 22: 1019-25. PMID 11408344 DOI: 10.1093/Carcin/22.7.1019  0.769
2001 Ames BN. DNA damage from micronutrient deficiencies is likely to be a major cause of cancer. Mutation Research. 475: 7-20. PMID 11295149 DOI: 10.1016/S0027-5107(01)00070-7  0.356
2000 Hagen TM, Vinarsky V, Wehr CM, Ames BN. (R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo. Antioxidants & Redox Signaling. 2: 473-83. PMID 11229361 DOI: 10.1089/15230860050192251  0.303
2000 Beckman KB, Saljoughi S, Mashiyama ST, Ames BN. A simpler, more robust method for the analysis of 8-oxoguanine in DNA. Free Radical Biology & Medicine. 29: 357-67. PMID 11035265 DOI: 10.1016/S0891-5849(00)00316-6  0.767
2000 Soultanakis RP, Melamede RJ, Bespalov IA, Wallace SS, Beckman KB, Ames BN, Taatjes DJ, Janssen-Heininger YM. Fluorescence detection of 8-oxoguanine in nuclear and mitochondrial DNA of cultured cells using a recombinant Fab and confocal scanning laser microscopy. Free Radical Biology & Medicine. 28: 987-98. PMID 10802231 DOI: 10.1016/S0891-5849(00)00185-4  0.351
2000 Atamna H, Cheung I, Ames BN. A method for detecting abasic sites in living cells: age-dependent changes in base excision repair. Proceedings of the National Academy of Sciences of the United States of America. 97: 686-91. PMID 10639140 DOI: 10.1073/Pnas.97.2.686  0.335
1999 Ames BN. Micronutrient deficiencies. A major cause of DNA damage. Annals of the New York Academy of Sciences. 889: 87-106. PMID 10668486 DOI: 10.1111/J.1749-6632.1999.Tb08727.X  0.358
1999 Beckman KB, Ames BN. Endogenous oxidative damage of mtDNA Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 424: 51-58. PMID 10064849 DOI: 10.1016/S0027-5107(99)00007-X  0.371
1998 Ames BN. Micronutrients prevent cancer and delay aging Toxicology Letters. 102: 5-18. PMID 10022226 DOI: 10.1016/S0378-4274(98)00269-0  0.392
1998 Hagen TM, Wehr CM, Ames BN. Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tert-butyl-α-phenyl-nitrone Annals of the New York Academy of Sciences. 854: 214-223. PMID 9928432 DOI: 10.1111/J.1749-6632.1998.Tb09904.X  0.315
1998 Beckman KB, Ames BN. Mitochondrial aging: Open questions Annals of the New York Academy of Sciences. 854: 118-127. PMID 9928425 DOI: 10.1111/J.1749-6632.1998.Tb09897.X  0.301
1998 Helbock HJ, Beckman KB, Ames BN. 8-Hydroxydeoxyguanosine and 8-hydroxyguanine as biomarkers of oxidative DNA damage Methods in Enzymology. 300: 156-166. PMID 9919519 DOI: 10.1016/S0076-6879(99)00123-8  0.36
1998 Lykkesfeldt J, Ames BN. Ascorbic acid recycling in rat hepatocytes as measurement of antioxidant capacity: Decline with age Methods in Enzymology. 299: 83-88. PMID 9916199 DOI: 10.1016/S0076-6879(99)99011-0  0.316
1998 Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BN. Age-associated decline in ascorbic acid concentration, recycling, and biosyntheis in rat hepatocytes - Reversal with (R)-α-lipoic acid supplementation Faseb Journal. 12: 1183-1189. PMID 9737721 DOI: 10.1096/Fasebj.12.12.1183  0.32
1998 Chen QM, Bartholomew JC, Campisi J, Acosta M, Reagan JD, Ames BN. Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication The Biochemical Journal. 332: Pt 1/-. PMID 9576849 DOI: 10.1042/Bj3320043  0.306
1998 Beckman KB, Ames BN. The free radical theory of aging matures Physiological Reviews. 78: 547-581. PMID 9562038 DOI: 10.1152/Physrev.1998.78.2.547  0.305
1998 Helbock HJ, Beckman KB, Shigenaga MK, Walter PB, Woodall AA, Yeo HC, Ames BN. DNA oxidation matters: The HPLC-electrochemical detection assay of 8- oxo-deoxyguanosine and 8-oxo-guanine Proceedings of the National Academy of Sciences of the United States of America. 95: 288-293. PMID 9419368 DOI: 10.1073/Pnas.95.1.288  0.379
1997 Beckman KB, Ames BN. Oxidative decay of DNA Journal of Biological Chemistry. 272: 19633-19636. PMID 9289489 DOI: 10.1074/Jbc.272.32.19633  0.342
1997 Koury MJ, Horne DW, Brown ZA, Pietenpol JA, Blount BC, Ames BN, Hard R, Koury ST. Apoptosis of late-stage erythroblasts in megaloblastic anemia: Association with DNA damage and macrocyte production Blood. 89: 4617-4623. PMID 9192787 DOI: 10.1182/Blood.V89.12.4617  0.319
1997 Blount BC, Mack MM, Wehr CM, MacGregor JT, Hiatt RA, Wang G, Wickramasinghe SN, Everson RB, Ames BN. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implications for cancer and neuronal damage Proceedings of the National Academy of Sciences of the United States of America. 94: 3290-3295. PMID 9096386 DOI: 10.1073/Pnas.94.7.3290  0.342
1997 Christen S, Woodall AA, Shigenaga MK, Southwell-Keely PT, Duncan MW, Ames BN. γ-Tocopherol traps mutagenic electrophiles such as NO(x) and complements α-tocopherol: Physiological implications Proceedings of the National Academy of Sciences of the United States of America. 94: 3217-3222. PMID 9096373 DOI: 10.1073/Pnas.94.7.3217  0.323
1997 Chen Q, Marsh J, Ames B, Mossman B. Detection of 8-oxo-2'-deoxyguanosine, a marker of oxidative DNA damage, in culture medium from human mesothelial cells exposed to crocidolite asbestos. Carcinogenesis. 17: 2525-7. PMID 8968073 DOI: 10.1093/Carcin/17.11.2525  0.386
1997 Ames BN. Q XVII B.4 The prevention of DNA damage: The role of nutrition Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 379: S172. DOI: 10.1016/S0027-5107(97)83213-7  0.302
1996 Beckman KB, Ames BN. [38] Detection and quantification of oxidative adducts of mitochondrial DNA Methods in Enzymology. 264: 442-453. PMID 8965717 DOI: 10.1016/S0076-6879(96)64040-3  0.338
1996 Liu J, Wang X, Shigenaga MK, Yeo HC, Mori A, Ames BN. Immobilization stress causes oxidative damage to lipid, protein, and DNA in the brain of rats Faseb Journal. 10: 1532-1538. PMID 8940299 DOI: 10.1096/Fasebj.10.13.8940299  0.336
1996 Christen S, Gee P, Ames BN. Mutagenicity of nitric oxide in base pair-specific Salmonella tester strains: TA7000 series Methods in Enzymology. 269: 267-278. PMID 8791655 DOI: 10.1016/S0076-6879(96)69027-2  0.337
1996 Helbock HJ, Thompson J, Yeo H, Ames BN. N2-methyl-8-oxoguanine: A tRNA urinary metabolite - Role of xanthine oxidase Free Radical Biology and Medicine. 20: 475-481. PMID 8720921 DOI: 10.1016/0891-5849(96)02052-7  0.324
1996 Park JYK, Shigenaga MK, Ames BN. Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage Proceedings of the National Academy of Sciences of the United States of America. 93: 2322-2327. PMID 8637871 DOI: 10.1073/Pnas.93.6.2322  0.387
1996 Fraga CG, Motchnik PA, Wyrobek AJ, Rempel DM, Ames BN. Smoking and low antioxidant levels increase oxidative damage to sperm DNA. Mutation Research. 351: 199-203. PMID 8622715 DOI: 10.1016/0027-5107(95)00251-0  0.337
1995 Blount BC, Ames BN. 2 DNA damage in folate deficiency Bailliere's Clinical Haematology. 8: 461-478. PMID 8534957 DOI: 10.1016/S0950-3536(05)80216-1  0.356
1995 Ames BN, Gold LS, Willett WC. The causes and prevention of cancer. Proceedings of the National Academy of Sciences of the United States of America. 92: 5258-65. PMID 7777494 DOI: 10.1073/Pnas.92.12.5258  0.344
1995 Chen Q, Fischer A, Reagan JD, Yan LJ, Ames BN. Oxidative DNA damage and senescence of human diploid fibroblast cells Proceedings of the National Academy of Sciences of the United States of America. 92: 4337-4341. PMID 7753808 DOI: 10.1073/Pnas.92.10.4337  0.358
1994 Tribble DL, van den Berg JJ, Motchnik PA, Ames BN, Lewis DM, Chait A, Krauss RM. Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content. Proceedings of the National Academy of Sciences of the United States of America. 91: 1183-7. PMID 8302851 DOI: 10.1073/Pnas.91.3.1183  0.314
1994 Chen Q, Ames BN. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells Proceedings of the National Academy of Sciences of the United States of America. 91: 4130-4134. PMID 8183882 DOI: 10.1073/Pnas.91.10.4130  0.304
1994 Shigenaga MK, Hagen TM, Ames BN. Oxidative damage and mitochondrial decay in aging Proceedings of the National Academy of Sciences of the United States of America. 91: 10771-10778. PMID 7971961 DOI: 10.1073/Pnas.91.23.10771  0.302
1994 Hagen TM, Huang S, Curnutte J, Fowler P, Martinez V, Wehr CM, Ames BN, Chisari FV. Extensive oxidative DNA damage in hepatocytes of transgenic mice with chronic active hepatitis destined to develop hepatocellular carcinoma Proceedings of the National Academy of Sciences of the United States of America. 91: 12808-12812. PMID 7809125 DOI: 10.1073/Pnas.91.26.12808  0.319
1994 Shigenaga MK, Aboujaoude EN, Chen Q, Ames BN. Assays of oxidative DNA damage biomarkers 8-oxo-2'-deoxyguanosine and 8- oxoguanine in nuclear DNA and biological fluids by high-performance liquid chromatography with electrochemical detection Methods in Enzymology. 234: 16-33. PMID 7808289 DOI: 10.1016/0076-6879(94)34073-0  0.366
1994 Youngman LD, Shigenaga M, Motchnik P, Ames BN. Effects of a peroxisomal proliferator (PP) on plasma and tissue levels of Coenzyme Q9 (CoQ), other antioxidants, and oxidative damage to DNA (oxo8dG): Evidence that PPs deplete antioxidants and increase oxidative damage to DNA Molecular Aspects of Medicine. 15: s131-s141. PMID 7752824 DOI: 10.1016/0098-2997(94)90022-1  0.363
1993 Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging Proceedings of the National Academy of Sciences of the United States of America. 90: 7915-7922. PMID 8367443 DOI: 10.1073/Pnas.90.17.7915  0.333
1993 Shigenaga MK, Ames BN. Oxidants and mitogenesis as causes of mutation and cancer: the influence of diet Basic Life Sciences. 61: 419-436. PMID 8304950 DOI: 10.1007/978-1-4615-2984-2_37  0.386
1993 Blount BC, Ames BN. Development of a sensitive assay for detection of uracil in DNA Advances in Experimental Medicine and Biology. 338: 741-744. PMID 8304219 DOI: 10.1007/978-1-4615-2960-6_154  0.354
1993 Ames BN, Shigenaga MK, Gold LS. DNA lesions, inducible DNA repair, and cell division: Three key factors in mutagenesis and carcinogenesis Environmental Health Perspectives. 101: 35-44. PMID 8013423 DOI: 10.1289/Ehp.93101S535  0.34
1992 Tartaglia LA, Gimeno CJ, Storz G, Ames BN. Multidegenerate DNA recognition by the OxyR transcriptional regulator. The Journal of Biological Chemistry. 267: 2038-45. PMID 1730735  0.552
1992 Wagner JR, Hu CC, Ames BN. Endogenous oxidative damage of deoxycytidine in DNA. Proceedings of the National Academy of Sciences of the United States of America. 89: 3380-4. PMID 1565630 DOI: 10.1073/Pnas.89.8.3380  0.37
1992 Cross CE, Motchnik PA, Bruener BA, Jones DA, Kaur H, Ames BN, Halliwell B. Oxidative damage to plasma constituents by ozone. Febs Letters. 298: 269-72. PMID 1544461 DOI: 10.1016/0014-5793(92)80074-Q  0.305
1992 Ames BN, Shigenaga MK. Oxidants are a major contributor to aging Annals of the New York Academy of Sciences. 663: 85-96. PMID 1482105 DOI: 10.1111/J.1749-6632.1992.Tb38652.X  0.379
1992 Youngman LD, Park JY, Ames BN. Protein oxidation associated with aging is reduced by dietary restriction of protein or calories. Proceedings of the National Academy of Sciences of the United States of America. 89: 9112-6. PMID 1409611 DOI: 10.1073/Pnas.89.19.9112  0.326
1991 Degan P, Shigenaga MK, Park EM, Alperin PE, Ames BN. Immunoaffinity isolation of urinary 8-hydroxy-2'-deoxyguanosine and 8-hydroxyguanine and quantitation of 8-hydroxy-2'-deoxyguanosine in DNA by polyclonal antibodies. Carcinogenesis. 12: 865-71. PMID 2029751 DOI: 10.1093/Carcin/12.5.865  0.3
1991 Jacob RA, Kelley DS, Pianalto FS, Swendseid ME, Henning SM, Zhang JZ, Ames BN, Fraga CG, Peters JH. Immunocompetence and oxidant defense during ascorbate depletion of healthy men. The American Journal of Clinical Nutrition. 54: 1302S-1309S. PMID 1962587 DOI: 10.1093/Ajcn/54.6.1302S  0.377
1991 Ames BN, Gold LS. Endogenous mutagens and the causes of aging and cancer. Mutation Research. 250: 3-16. PMID 1944345 DOI: 10.1016/0027-5107(91)90157-J  0.329
1991 Fraga CG, Motchnik PA, Shigenaga MK, Helbock HJ, Jacob RA, Ames BN. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proceedings of the National Academy of Sciences of the United States of America. 88: 11003-6. PMID 1763015 DOI: 10.1073/Pnas.88.24.11003  0.387
1991 Shigenaga MK, Ames BN. Assays for 8-hydroxy-2'-deoxyguanosine: a biomarker of in vivo oxidative DNA damage. Free Radical Biology & Medicine. 10: 211-6. PMID 1650737 DOI: 10.1016/0891-5849(91)90078-H  0.38
1991 Ames BN, Shigenaga MK, Park E. Dna Damage By Endogenous Oxidants As A Cause Of Aging And Cancer Oxidative Damage & Repairchemical, Biological and Medical Aspects. 181-187. DOI: 10.1016/B978-0-08-041749-3.50037-1  0.356
1990 Shigenaga MK, Gimeno CJ, Ames BN. Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage. Proceedings of the National Academy of Sciences of the United States of America. 86: 9697-701. PMID 2602371 DOI: 10.1073/Pnas.86.24.9697  0.377
1990 Fraga CG, Shigenaga MK, Park JW, Degan P, Ames BN. Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine. Proceedings of the National Academy of Sciences of the United States of America. 87: 4533-7. PMID 2352934 DOI: 10.1073/Pnas.87.12.4533  0.376
1990 Storz G, Tartaglia LA, Ames BN. The OxyR regulon. Antonie Van Leeuwenhoek. 58: 157-61. PMID 2256675 DOI: 10.1007/Bf00548927  0.583
1990 Frei B, Stocker R, England L, Ames BN. Ascorbate: the most effective antioxidant in human blood plasma. Advances in Experimental Medicine and Biology. 264: 155-63. PMID 2244489 DOI: 10.1007/978-1-4684-5730-8_24  0.322
1990 Shigenaga MK, Park JW, Cundy KC, Gimeno CJ, Ames BN. In vivo oxidative DNA damage: measurement of 8-hydroxy-2'-deoxyguanosine in DNA and urine by high-performance liquid chromatography with electrochemical detection. Methods in Enzymology. 186: 521-30. PMID 2233317 DOI: 10.1016/0076-6879(90)86146-M  0.372
1990 Tartaglia LA, Storz G, Brodsky MH, Lai A, Ames BN. Alkyl hydroperoxide reductase from Salmonella typhimurium. Sequence and homology to thioredoxin reductase and other flavoprotein disulfide oxidoreductases. The Journal of Biological Chemistry. 265: 10535-40. PMID 2191951  0.529
1990 Storz G, Tartaglia LA, Ames BN. Transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation. Science (New York, N.Y.). 248: 189-94. PMID 2183352 DOI: 10.1126/Science.2183352  0.584
1990 Storz G, Tartaglia LA, Farr SB, Ames BN. Bacterial defenses against oxidative stress. Trends in Genetics : Tig. 6: 363-8. PMID 1965068 DOI: 10.1016/0168-9525(90)90278-E  0.588
1990 Hagen TM, Shigenaga MK, Kitzler JW, Ames BN. Increased oxidative DNA damage following partial hepatectomy Free Radical Biology and Medicine. 9: 49. DOI: 10.1016/0891-5849(90)90344-I  0.361
1990 Ames BN. Oxidative DNA damage and aging Free Radical Biology and Medicine. 9: 45. DOI: 10.1016/0891-5849(90)90326-E  0.349
1989 Cundy KC, Kohen R, Ames BN. Determination of 8-hydroxydeoxyguanosine in human urine: a possible assay for in vivo oxidative DNA damage. Basic Life Sciences. 49: 479-82. PMID 3250506 DOI: 10.1007/978-1-4684-5568-7_74  0.349
1989 Frei B, Stocker R, Ames BN. Antioxidant defenses and lipid peroxidation in human blood plasma. Proceedings of the National Academy of Sciences of the United States of America. 85: 9748-52. PMID 3200852 DOI: 10.1073/Pnas.85.24.9748  0.319
1989 Frei B, England L, Ames BN. Ascorbate is an outstanding antioxidant in human blood plasma. Proceedings of the National Academy of Sciences of the United States of America. 86: 6377-81. PMID 2762330 DOI: 10.1073/Pnas.86.16.6377  0.314
1989 Tartaglia LA, Storz G, Ames BN. Identification and molecular analysis of oxyR-regulated promoters important for the bacterial adaptation to oxidative stress. Journal of Molecular Biology. 210: 709-19. PMID 2693740 DOI: 10.1016/0022-2836(89)90104-6  0.57
1989 Ames BN. Endogenous DNA damage as related to cancer and aging Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 214: 41-46. PMID 2671700 DOI: 10.1016/0027-5107(89)90196-6  0.37
1989 Ames BN. Mutagenesis and carcinogenesis: Endogenous and exogenous factors Environmental and Molecular Mutagenesis. 14: 66-77. PMID 2659334 DOI: 10.1002/Em.2850140614  0.313
1989 Park JW, Cundy KC, Ames BN. Detection of DNA adducts by high-performance liquid chromatography with electrochemical detection. Carcinogenesis. 10: 827-32. PMID 2650907 DOI: 10.1093/Carcin/10.5.827  0.363
1989 Storz G, Jacobson FS, Tartaglia LA, Morgan RW, Silveira LA, Ames BN. An alkyl hydroperoxide reductase induced by oxidative stress in Salmonella typhimurium and Escherichia coli: genetic characterization and cloning of ahp. Journal of Bacteriology. 171: 2049-55. PMID 2649484 DOI: 10.1128/Jb.171.4.2049-2055.1989  0.581
1989 Christman MF, Storz G, Ames BN. OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins Proceedings of the National Academy of Sciences of the United States of America. 86: 3484-3488. PMID 2471187 DOI: 10.1073/Pnas.86.10.3484  0.592
1988 Richter C, Park JW, Ames BN. Normal oxidative damage to mitochondrial and nuclear DNA is extensive Proceedings of the National Academy of Sciences of the United States of America. 85: 6465-6467. PMID 3413108 DOI: 10.1073/Pnas.85.17.6465  0.372
1988 Kramer GF, Baker JC, Ames BN. Near-UV stress in Salmonella typhimurium: 4-thiouridine in tRNA, ppGpp, and ApppGpp as components of an adaptive response. Journal of Bacteriology. 170: 2344-51. PMID 3283108 DOI: 10.1128/Jb.170.5.2344-2351.1988  0.309
1988 Adelman R, Saul RL, Ames BN. Oxidative damage to DNA: relation to species metabolic rate and life span Proceedings of the National Academy of Sciences of the United States of America. 85: 2706-2708. PMID 3128794 DOI: 10.1073/Pnas.85.8.2706  0.37
1988 Kramer GF, Ames BN. Mechanisms of mutagenicity and toxicity of sodium selenite (Na2SeO3) in Salmonella typhimurium. Mutation Research. 201: 169-80. PMID 2843765 DOI: 10.1016/0027-5107(88)90123-6  0.336
1988 Baker JC, Ames BN. Alterations in levels of 5'-adenyl dinucleotides following DNA damage in normal human fibroblasts and fibroblasts derived from patients with xeroderma pigmentosum. Mutation Research. 208: 87-93. PMID 2454402 DOI: 10.1016/S0165-7992(98)90005-7  0.347
1988 Kramer GF, Ames BN. Isolation and characterization of a selenium metabolism mutant of Salmonella typhimurium. Journal of Bacteriology. 170: 736-43. PMID 2448290 DOI: 10.1128/Jb.170.2.736-743.1988  0.309
1987 Stocker R, Glazer AN, Ames BN. Antioxidant activity of albumin-bound bilirubin. Proceedings of the National Academy of Sciences of the United States of America. 84: 5918-22. PMID 3475708 DOI: 10.1073/Pnas.84.16.5918  0.32
1987 Storz G, Christman MF, Sies H, Ames BN. Spontaneous mutagenesis and oxidative damage to DNA in Salmonella typhimurium Proceedings of the National Academy of Sciences of the United States of America. 84: 8917-8921. PMID 3321061 DOI: 10.1073/Pnas.84.24.8917  0.607
1986 Saul RL, Ames BN. Background levels of DNA damage in the population Basic Life Sciences. 38: 529-535. PMID 3741344 DOI: 10.1007/978-1-4615-9462-8_55  0.364
1986 Morgan RW, Christman MF, Jacobson FS, Storz G, Ames BN. Hydrogen peroxide-inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins Proceedings of the National Academy of Sciences of the United States of America. 83: 8059-8063. PMID 3534881 DOI: 10.1073/Pnas.83.21.8059  0.544
1986 Hartman PE, Ames BN, Roth JR, Barnes WM, Levin DE. Target sequences for mutagenesis in Salmonella histidine-requiring mutants. Environmental Mutagenesis. 8: 631-41. PMID 3525139 DOI: 10.1002/Em.2860080414  0.727
1986 Levin DE, Ames BN. Classifying mutagens as to their specificity in causing the six possible transitions and transversions: A simple analysis using the Salmonella mutagenicity assay Environmental Mutagenesis. 8: 9-28. PMID 2417830 DOI: 10.1002/Em.2860080103  0.598
1985 Marnett LJ, Hurd HK, Hollstein MC, Levin DE, Esterbauer H, Ames BN. Naturally occurring carbonyl compounds are mutagens in Salmonella tester strain TA104. Mutation Research. 148: 25-34. PMID 3881660 DOI: 10.1016/0027-5107(85)90204-0  0.595
1985 Christman MF, Morgan RW, Jacobson FS, Ames BN. Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium Cell. 41: 753-762. PMID 2988786 DOI: 10.1016/S0092-8674(85)80056-8  0.303
1984 Cathcart R, Schwiers E, Saul RL, Ames BN. Thymine glycol and thymidine glycol in human and rat urine: A possible assay for oxidative DNA damage Proceedings of the National Academy of Sciences of the United States of America. 81: 5633-5637. PMID 6592579 DOI: 10.1073/Pnas.81.18.5633  0.386
1984 Hollstein MC, Brooks P, Linn S, Ames BN. Hydroxymethyluracil DNA glycosylase in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 81: 4003-7. PMID 6588376 DOI: 10.1073/Pnas.81.13.4003  0.347
1984 Chesis PL, Levin DE, Smith MT, Ernster L, Ames BN. Mutagenicity of quinones: pathways of metabolic activation and detoxification. Proceedings of the National Academy of Sciences of the United States of America. 81: 1696-700. PMID 6584903 DOI: 10.1073/Pnas.81.6.1696  0.574
1984 Levin DE, Marnett LJ, Ames BN. Spontaneous and mutagen-induced deletions: mechanistic studies in Salmonella tester strain TA102. Proceedings of the National Academy of Sciences of the United States of America. 81: 4457-61. PMID 6379645 DOI: 10.1073/Pnas.81.14.4457  0.61
1984 Levin DE, Hollstein M, Christman MF, Ames BN. Detection of oxidative mutagens with a new Salmonella tester strain (TA102) Methods in Enzymology. 249-254. PMID 6374371 DOI: 10.1016/S0076-6879(84)05032-1  0.627
1984 Bochner BR, Lee PC, Wilson SW, Cutler CW, Ames BN. AppppA and related adenylylated nucleotides are synthesized as a consequence of oxidation stress. Cell. 37: 225-32. PMID 6373012 DOI: 10.1016/0092-8674(84)90318-0  0.338
1983 Ames BN. Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases Science. 221: 1256-1263. PMID 6351251 DOI: 10.1126/Science.6351251  0.322
1982 Levin DE, Hollstein M, Christman MF, Schwiers EA, Ames BN. A new Salmonella tester strain (TA102) with A.T base pairs at the site of mutation detects oxidative mutagens Proceedings of the National Academy of Sciences of the United States of America. 79: 7445-7449. PMID 6760198 DOI: 10.1073/Pnas.79.23.7445  0.605
1982 Levin DE, Yamasaki E, Ames BN. A new Salmonella tester strain, TA97, for the detection of frameshift mutagens. A run of cytosines as a mutational hot-spot. Mutation Research. 94: 315-30. PMID 6125883 DOI: 10.1016/0027-5107(82)90294-9  0.587
1981 Ames BN, Cathcart R, Schwiers E, Hochstein P. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proceedings of the National Academy of Sciences of the United States of America. 78: 6858-62. PMID 6947260 DOI: 10.1073/Pnas.78.11.6858  0.341
1979 Ames BN. Identifying environmental chemicals causing mutations and cancer Science. 204: 587-593. PMID 373122 DOI: 10.1126/Science.373122  0.335
1976 McCann J, Choi E, Yamasaki E, Ames BN. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals. Proceedings of the National Academy of Sciences of the United States of America. 72: 5135-9. PMID 1061098 DOI: 10.1073/Pnas.72.12.5135  0.306
1976 McCann J, Ames BN. Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion. Proceedings of the National Academy of Sciences of the United States of America. 73: 950-4. PMID 768988 DOI: 10.1073/Pnas.73.3.950  0.32
1975 Cieslà Z, Salvatore F, Broach JR, Artz SW, Ames BN. Histidine regulation in Salmonella typhimurium. XVI. A sensitive radiochemical assay for histidinol dehydrogenase. Analytical Biochemistry. 63: 44-55. PMID 1089301 DOI: 10.1016/0003-2697(75)90187-6  0.544
1974 Ames BN, Durston WE, Yamasaki E, Lee FD. Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. Proceedings of the National Academy of Sciences of the United States of America. 70: 2281-5. PMID 4151811 DOI: 10.1073/Pnas.70.8.2281  0.317
1973 Ames BN, Lee FD, Durston WE. An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proceedings of the National Academy of Sciences of the United States of America. 70: 782-6. PMID 4577135 DOI: 10.1073/Pnas.70.3.782  0.301
1973 Ames BN, Gurney EG, Miller JA, Bartsch H. Carcinogens as frameshift mutagens: metabolites and derivatives of 2-acetylaminofluorene and other aromatic amine carcinogens. Proceedings of the National Academy of Sciences of the United States of America. 69: 3128-32. PMID 4564203 DOI: 10.1073/Pnas.69.11.3128  0.339
1972 Singer CE, Smith GR, Cortese R, Ames BN. [Mutant tRNA His ineffective in repression and lacking two pseudouridine modifications]. Nature: New Biology. 238: 72-4. PMID 4558263 DOI: 10.1038/Newbio238072A0  0.53
1971 Guirard BM, Ames BN, Snell EE. Salmonella typhimurium mutants with alternate requirements for vitamin B 6 or isoleucine. Journal of Bacteriology. 108: 359-63. PMID 4941563 DOI: 10.1128/Jb.108.1.359-363.1971  0.316
1971 Hong JS, Smith GR, Ames BN. Adenosine 3':5'-cyclic monophosphate concentration in the bacterial host regulates the viral decision between lysogeny and lysis. Proceedings of the National Academy of Sciences of the United States of America. 68: 2258-62. PMID 4332251 DOI: 10.1073/Pnas.68.9.2258  0.527
1971 Chang GW, Roth JR, Ames BN. Histidine Regulation in Salmonella typhimurium VIII. Mutations of the hisT Gene Journal of Bacteriology. 108: 410-414. DOI: 10.1128/Jb.108.1.410-414.1971  0.526
1970 Singer CE, Ames BN. Sunlight ultraviolet and bacterial DNA base ratios Science. 170: 822-826. PMID 5473414 DOI: 10.1126/Science.170.3960.822  0.308
1968 Berkowitz D, Hushon JM, Whitfield HJ, Roth J, Ames BN. Procedure for Identifying Nonsense Mutations Journal of Bacteriology. 96: 215-220. PMID 4874308 DOI: 10.1128/Jb.96.1.215-220.1968  0.537
1967 Fink GR, Klopotowski T, Ames BN. Histidine regulatory mutants in Salmonella typhimurium. IV. A positive selection for polar histidine-requiring mutants from histidine operator constitutive mutants. Journal of Molecular Biology. 30: 81-95. PMID 4294871  0.389
1966 Silbert DF, Fink GR, Ames BN. Histidine regulatory mutants in Salmonella typhimurium 3. A class of regulatory mutants deficient in tRNA for histidine. Journal of Molecular Biology. 22: 335-47. PMID 5339689  0.626
1966 Roth JR, Ames BN. Histidine regulatory mutants in Salmonella typhimurium. II. Histidine regulatory mutants having altered histidyl-tRNA synthetase Journal of Molecular Biology. 22: 325-334. PMID 5339688 DOI: 10.1016/0022-2836(66)90135-5  0.494
1966 Roth JR, Silbert DF, Fink GR, Voll MJ, Antón D, Hartman PE, Ames BN. Transfer RNA and the control of the histidine operon. Cold Spring Harbor Symposia On Quantitative Biology. 31: 383-92. PMID 4866388 DOI: 10.1101/Sqb.1966.031.01.050  0.732
1963 AMES BN, HARTMAN PE, JACOB F. Chromosomal alterations affecting the regulation of histidine biosynthetic enzymes in Salmonella. Journal of Molecular Biology. 7: 23-42. PMID 14012567 DOI: 10.1016/S0022-2836(63)80016-9  0.463
1963 Ames BN, Hartman PE. The Histidine Operon Cold Spring Harbor Symposia On Quantitative Biology. 28: 349-356. DOI: 10.1101/Sqb.1963.028.01.049  0.491
1955 AMES BN, MITCHELL HK. The biosynthesis of histidine; imidazoleglycerol phosphate, imidazoleacetol phosphate, and histidinol phosphate. The Journal of Biological Chemistry. 212: 687-96. PMID 14353870  0.455
1952 Haas F, Mitchell MB, Ames BN, Mitchell HK. A Series of Histidineless Mutants of Neurospora Crassa. Genetics. 37: 217-26. PMID 17247387  0.481
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