Fredric P. Manfredsson, Ph.D. - Publications

Affiliations: 
Translational Science & Molecular Medicine Michigan State University, East Lansing, MI 

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wang ZH, Xiang J, Liu X, Yu SP, Manfredsson FP, Sandoval IM, Wu S, Wang JZ, Ye K. Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease. Cell Reports. 28: 655-669.e5. PMID 31315045 DOI: 10.1016/j.celrep.2019.06.054  0.68
2019 Romoli B, Lozada AF, Sandoval IM, Manfredsson FP, Hnasko TS, Berg DK, Dulcis D. Neonatal Nicotine Exposure Primes Midbrain Neurons to a Dopaminergic Phenotype and Increases Adult Drug Consumption. Biological Psychiatry. PMID 31202491 DOI: 10.1016/j.biopsych.2019.04.019  0.68
2019 Xiang J, Wang ZH, Ahn EH, Liu X, Yu SP, Manfredsson FP, Sandoval IM, Ju G, Wu S, Ye K. Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies. Proceedings of the National Academy of Sciences of the United States of America. PMID 31004063 DOI: 10.1073/pnas.1901348116  0.68
2019 Steece-Collier K, Stancati JA, Collier NJ, Sandoval IM, Mercado NM, Sortwell CE, Collier TJ, Manfredsson FP. Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31002755 DOI: 10.1002/mds.27695  1
2019 Sandoval IM, Kuhn NM, Manfredsson FP. Multimodal Production of Adeno-Associated Virus. Methods in Molecular Biology (Clifton, N.J.). 1937: 101-124. PMID 30706392 DOI: 10.1007/978-1-4939-9065-8_6  0.68
2019 Sandoval IM, Collier TJ, Manfredsson FP. Design and Assembly of CRISPR/Cas9 Lentiviral and rAAV Vectors for Targeted Genome Editing. Methods in Molecular Biology (Clifton, N.J.). 1937: 29-45. PMID 30706388 DOI: 10.1007/978-1-4939-9065-8_2  0.68
2019 Benskey MJ, Sandoval IM, Miller K, Sellnow RL, Gezer A, Kuhn NC, Vashon R, Manfredsson FP. Basic Concepts in Viral Vector-Mediated Gene Therapy. Methods in Molecular Biology (Clifton, N.J.). 1937: 3-26. PMID 30706387 DOI: 10.1007/978-1-4939-9065-8_1  0.68
2019 Sellnow RC, Newman JH, Chambers N, West AR, Steece-Collier K, Sandoval IM, Benskey MJ, Bishop C, Manfredsson FP. Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia. Acta Neuropathologica Communications. 7: 8. PMID 30646956 DOI: 10.1186/s40478-018-0653-7  0.68
2018 Wang ZH, Wu W, Kang SS, Liu X, Wu Z, Peng J, Yu SP, Manfredsson FP, Sandoval IM, Liu X, Wang JZ, Ye K. BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT. Jci Insight. 3. PMID 30135302 DOI: 10.1172/jci.insight.99007  0.68
2018 Raghunathan R, Polinski NK, Klein JA, Hogan JD, Shao C, Khatri K, Leon DR, McComb ME, Manfredsson FP, Sortwell CE, Zaia J. Glycomic and Proteomic changes in aging brain nigrostriatal pathway. Molecular & Cellular Proteomics : McP. PMID 29915149 DOI: 10.1074/mcp.RA118.000680  1
2018 Kang SS, Ahn EH, Zhang Z, Liu X, Manfredsson FP, Sandoval IM, Dhakal S, Iuvone PM, Cao X, Ye K. α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease. The Embo Journal. PMID 29769405 DOI: 10.15252/embj.201798878  0.68
2018 Wang ZH, Gong K, Liu X, Zhang Z, Sun X, Wei ZZ, Yu SP, Manfredsson FP, Sandoval IM, Johnson PF, Jia J, Wang JZ, Ye K. C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease. Nature Communications. 9: 1784. PMID 29725016 DOI: 10.1038/s41467-018-04120-z  0.68
2018 Benskey MJ, Sellnow RC, Sandoval IM, Sortwell CE, Lipton JW, Manfredsson FP. Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity. Frontiers in Molecular Neuroscience. 11: 36. PMID 29497361 DOI: 10.3389/fnmol.2018.00036  1
2018 Manfredsson FP, Luk KC, Benskey MJ, Guezer A, Garcia J, Kuhn NC, Sandoval IM, Patterson JR, O'Mara A, Yonkers R, Kordower JH. Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology. Neurobiology of Disease. PMID 29341898 DOI: 10.1016/j.nbd.2018.01.008  0.68
2017 Fischer DL, Manfredsson FP, Kemp CJ, Cole-Strauss A, Lipton JW, Duffy MF, Polinski NK, Steece-Collier K, Collier TJ, Gombash SE, Buhlinger DJ, Sortwell CE. Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression. Scientific Reports. 7: 16356. PMID 29180681 DOI: 10.1038/s41598-017-16690-x  1
2017 Fischer DL, Manfredsson FP, Sortwell CE. Can STN DBS protect both nigral somata and innervation of the striatum? Annals of Neurology. PMID 28985650 DOI: 10.1002/ana.25064  1
2017 Kang SS, Zhang Z, Liu X, Manfredsson FP, Benskey MJ, Cao X, Xu J, Sun YE, Ye K. TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28923922 DOI: 10.1073/pnas.1713969114  0.68
2017 Kanaan NM, Sellnow RC, Boye SL, Coberly B, Bennett A, Agbandje-McKenna M, Sortwell CE, Hauswirth WW, Boye SE, Manfredsson FP. Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS. Molecular Therapy. Nucleic Acids. 8: 184-197. PMID 28918020 DOI: 10.1016/j.omtn.2017.06.011  1
2017 Wang ZH, Liu P, Liu X, Manfredsson FP, Sandoval IM, Yu SP, Wang JZ, Ye K. Delta-Secretase Phosphorylation by SRPK2 Enhances Its Enzymatic Activity, Provoking Pathogenesis in Alzheimer's Disease. Molecular Cell. PMID 28826672 DOI: 10.1016/j.molcel.2017.07.018  0.68
2017 Zhang Z, Kang SS, Liu X, Ahn EH, Zhang Z, He L, Iuvone PM, Duong DM, Seyfried NT, Benskey MJ, Manfredsson FP, Jin L, Sun YE, Wang JZ, Ye K. Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease. Nature Structural & Molecular Biology. PMID 28671665 DOI: 10.1038/nsmb.3433  0.68
2017 Pathak D, Berthet A, Bendor JT, Yu K, Sellnow RC, Orr AL, Nguyen MK, Edwards RH, Manfredsson FP, Nakamura K. Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. Eneuro. 4. PMID 28462393 DOI: 10.1523/ENEURO.0216-16.2017  0.68
2016 Polinski NK, Manfredsson FP, Benskey MJ, Fischer DL, Kemp CJ, Steece-Collier K, Sandoval IM, Paumier KL, Sortwell CE. Impact of age and vector construct on striatal and nigral transgene expression. Molecular Therapy. Methods & Clinical Development. 3: 16082. PMID 27933309 DOI: 10.1038/mtm.2016.82  1
2016 Kneynsberg A, Collier TJ, Manfredsson FP, Kanaan NM. Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures. Journal of Neuroscience Methods. 266: 32-41. PMID 27031947 DOI: 10.1016/j.jneumeth.2016.03.004  0.64
2016 Benskey MJ, Sandoval IM, Manfredsson FP. Continuous Collection of Adeno-Associated Virus from Producer Cell Medium Significantly Increases Total Viral Yield. Human Gene Therapy Methods. 27: 32-45. PMID 26863210 DOI: 10.1089/hgtb.2015.117  0.76
2016 Collier TJ, Redmond DE, Steece-Collier K, Lipton JW, Manfredsson FP. Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates. Frontiers in Neuroscience. 10: 12. PMID 26858591 DOI: 10.3389/fnins.2016.00012  0.76
2016 Benskey MJ, Perez RG, Manfredsson FP. The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease. Journal of Neurochemistry. 137: 331-59. PMID 26852372 DOI: 10.1111/jnc.13570  0.68
2016 Fischer DL, Gombash SE, Kemp CJ, Manfredsson FP, Polinski NK, Duffy MF, Sortwell CE. Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson's Disease. Methods in Molecular Biology (Clifton, N.J.). 1382: 367-82. PMID 26611600 DOI: 10.1007/978-1-4939-3271-9_26  0.76
2016 Benskey MJ, Manfredsson FP. Gene Therapy of the Peripheral Nervous System: The Enteric Nervous System. Methods in Molecular Biology (Clifton, N.J.). 1382: 263-74. PMID 26611593 DOI: 10.1007/978-1-4939-3271-9_19  0.76
2016 Benskey MJ, Manfredsson FP. Intraparenchymal Stereotaxic Delivery of rAAV and Special Considerations in Vector Handling. Methods in Molecular Biology (Clifton, N.J.). 1382: 199-215. PMID 26611588 DOI: 10.1007/978-1-4939-3271-9_14  0.76
2016 Benskey MJ, Manfredsson FP. Lentivirus Production and Purification. Methods in Molecular Biology (Clifton, N.J.). 1382: 107-14. PMID 26611582 DOI: 10.1007/978-1-4939-3271-9_8  0.76
2016 Manfredsson FP. Introduction to Viral Vectors and Other Delivery Methods for Gene Therapy of the Nervous System. Methods in Molecular Biology (Clifton, N.J.). 1382: 3-18. PMID 26611575 DOI: 10.1007/978-1-4939-3271-9_1  0.76
2015 Fischer DL, Collier TJ, Cole-Strauss A, Wohlgenant SL, Lipton JW, Steece-Collier K, Manfredsson FP, Kemp CJ, Sortwell CE. High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine. Plos One. 10: e0133957. PMID 26222442 DOI: 10.1371/journal.pone.0133957  0.76
2015 Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, Sandoval IM, Fleming S, Dirr E, Polinski NK, Trojanowski JQ, et al. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiology of Disease. 82: 185-199. PMID 26093169 DOI: 10.1016/j.nbd.2015.06.003  0.76
2015 Kanaan NM, Collier TJ, Cole-Strauss A, Grabinski T, Mattingly ZR, Winn ME, Steece-Collier K, Sortwell CE, Manfredsson FP, Lipton JW. The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes. Plos One. 10: e0127768. PMID 25992874 DOI: 10.1371/journal.pone.0127768  0.76
2015 Grabinski TM, Kneynsberg A, Manfredsson FP, Kanaan NM. A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures. Plos One. 10: e0120120. PMID 25794171 DOI: 10.1371/journal.pone.0120120  0.76
2015 Benskey MJ, Kuhn NC, Galligan JJ, Garcia J, Boye SE, Hauswirth WW, Mueller C, Boye SL, Manfredsson FP. Targeted gene delivery to the enteric nervous system using AAV: a comparison across serotypes and capsid mutants. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 488-500. PMID 25592336 DOI: 10.1038/mt.2015.7  0.76
2015 Polinski NK, Gombash SE, Manfredsson FP, Lipton JW, Kemp CJ, Cole-Strauss A, Kanaan NM, Steece-Collier K, Kuhn NC, Wohlgenant SL, Sortwell CE. Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain. Neurobiology of Aging. 36: 1110-20. PMID 25457558 DOI: 10.1016/j.neurobiolaging.2014.07.047  0.76
2015 Benskey MJ, Manfredsson FP, Lookingland KJ, Goudreau JL. The role of parkin in the differential susceptibility of tuberoinfundibular and nigrostriatal dopamine neurons to acute toxicant exposure. Neurotoxicology. 46: 1-11. PMID 25447324 DOI: 10.1016/j.neuro.2014.11.004  0.76
2014 Gombash SE, Manfredsson FP, Mandel RJ, Collier TJ, Fischer DL, Kemp CJ, Kuhn NM, Wohlgenant SL, Fleming SM, Sortwell CE. Neuroprotective potential of pleiotrophin overexpression in the striatonigral pathway compared with overexpression in both the striatonigral and nigrostriatal pathways. Gene Therapy. 21: 682-93. PMID 24807806 DOI: 10.1038/gt.2014.42  0.76
2013 Gombash SE, Manfredsson FP, Kemp CJ, Kuhn NC, Fleming SM, Egan AE, Grant LM, Ciucci MR, MacKeigan JP, Sortwell CE. Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system. Plos One. 8: e81426. PMID 24312298 DOI: 10.1371/journal.pone.0081426  0.76
2013 Plowman EK, Maling N, Rivera BJ, Larson K, Thomas NJ, Fowler SC, Manfredsson FP, Shrivastav R, Kleim JA. Differential sensitivity of cranial and limb motor function to nigrostriatal dopamine depletion. Behavioural Brain Research. 237: 157-63. PMID 23018122 DOI: 10.1016/j.bbr.2012.09.031  0.76
2013 Manfredsson FP. Viral-Mediated Delivery of shRNA and miRNA Advanced Delivery and Therapeutic Applications of Rnai. 225-254. DOI: 10.1002/9781118610749.ch11  0.76
2012 Kanaan NM, Manfredsson FP. Loss of functional alpha-synuclein: a toxic event in Parkinson's disease? Journal of Parkinson's Disease. 2: 249-67. PMID 23938255 DOI: 10.3233/JPD-012138  0.76
2012 Manfredsson FP, Bloom DC, Mandel RJ. Regulated protein expression for in vivo gene therapy for neurological disorders: progress, strategies, and issues. Neurobiology of Disease. 48: 212-21. PMID 22426391 DOI: 10.1016/j.nbd.2012.03.001  0.76
2012 Gombash SE, Lipton JW, Collier TJ, Madhavan L, Steece-Collier K, Cole-Strauss A, Terpstra BT, Spieles-Engemann AL, Daley BF, Wohlgenant SL, Thompson VB, Manfredsson FP, Mandel RJ, Sortwell CE. Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 544-54. PMID 22008908 DOI: 10.1038/mt.2011.216  0.76
2011 Manfredsson FP, Mandel RJ. The development of flexible lentiviral vectors for gene transfer in the CNS. Experimental Neurology. 229: 201-6. PMID 21459087 DOI: 10.1016/j.expneurol.2011.03.013  0.76
2010 Gorbatyuk OS, Li S, Nash K, Gorbatyuk M, Lewin AS, Sullivan LF, Mandel RJ, Chen W, Meyers C, Manfredsson FP, Muzyczka N. In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1450-1457. PMID 28178505 DOI: 10.1038/mt.2010.115  0.36
2010 Gorbatyuk OS, Li S, Nguyen FN, Manfredsson FP, Kondrikova G, Sullivan LF, Meyers C, Chen W, Mandel RJ, Muzyczka N. α-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1758-68. PMID 20664530 DOI: 10.1038/mt.2010.137  0.76
2010 Gorbatyuk OS, Li S, Nash K, Gorbatyuk M, Lewin AS, Sullivan LF, Mandel RJ, Chen W, Meyers C, Manfredsson FP, Muzyczka N. In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1450-7. PMID 20551914 DOI: 10.1038/mt.2010.115  0.76
2010 Manfredsson FP, Mandel RJ. Development of gene therapy for neurological disorders. Discovery Medicine. 9: 204-11. PMID 20350486  0.76
2009 Manfredsson FP, Okun MS, Mandel RJ. Gene therapy for neurological disorders: challenges and future prospects for the use of growth factors for the treatment of Parkinson's disease. Current Gene Therapy. 9: 375-88. PMID 19860652 DOI: 10.2174/156652309789753400  0.76
2009 Manfredsson FP, Burger C, Rising AC, Zuobi-Hasona K, Sullivan LF, Lewin AS, Huang J, Piercefield E, Muzyczka N, Mandel RJ. Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1857-67. PMID 19707186 DOI: 10.1038/mt.2009.196  0.76
2009 Manfredsson FP, Tumer N, Erdos B, Landa T, Broxson CS, Sullivan LF, Rising AC, Foust KD, Zhang Y, Muzyczka N, Gorbatyuk OS, Scarpace PJ, Mandel RJ. Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 980-91. PMID 19277011 DOI: 10.1038/mt.2009.45  0.76
2009 Manfredsson FP, Rising AC, Mandel RJ. AAV9: a potential blood-brain barrier buster. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 403-5. PMID 19247366 DOI: 10.1038/mt.2009.15  0.76
2009 Peden CS, Manfredsson FP, Reimsnider SK, Poirier AE, Burger C, Muzyczka N, Mandel RJ. Striatal readministration of rAAV vectors reveals an immune response against AAV2 capsids that can be circumvented. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 524-37. PMID 19142181 DOI: 10.1038/mt.2008.284  0.76
2008 Gorbatyuk OS, Li S, Sullivan LF, Chen W, Kondrikova G, Manfredsson FP, Mandel RJ, Muzyczka N. The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 763-8. PMID 18178617 DOI: 10.1073/pnas.0711053105  0.76
2007 Manfredsson FP, Burger C, Sullivan LF, Muzyczka N, Lewin AS, Mandel RJ. rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease. Experimental Neurology. 207: 289-301. PMID 17678648 DOI: 10.1016/j.expneurol.2007.06.019  0.76
2007 Reimsnider S, Manfredsson FP, Muzyczka N, Mandel RJ. Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1504-11. PMID 17565350 DOI: 10.1038/sj.mt.6300227  0.76
2006 Mandel RJ, Manfredsson FP, Foust KD, Rising A, Reimsnider S, Nash K, Burger C. Recombinant adeno-associated viral vectors as therapeutic agents to treat neurological disorders. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 463-83. PMID 16412695 DOI: 10.1016/j.ymthe.2005.11.009  0.76
2006 Manfredsson FP, Lewin AS, Mandel RJ. RNA knockdown as a potential therapeutic strategy in Parkinson's disease. Gene Therapy. 13: 517-24. PMID 16267570 DOI: 10.1038/sj.gt.3302669  0.76
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