Fredric P. Manfredsson, Ph.D. - Publications

Translational Science & Molecular Medicine Michigan State University, East Lansing, MI 

77 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Joers V, Murray BC, McLaughlin C, Oliver D, Staley H, Coronado J, Achat-Mendes C, Golshani S, Kelly SD, Goodson M, Lee D, Manfredsson FP, Moore BM, Tansey MG. Modulation of cannabinoid receptor 2 alters neuroinflammation and reduces formation of alpha-synuclein aggregates in a rat model of nigral synucleinopathy. Biorxiv : the Preprint Server For Biology. PMID 38562842 DOI: 10.1101/2023.08.25.554814  0.317
2023 Kasanga EA, Han Y, Navarrete W, McManus R, Shifflet MK, Parry C, Barahona A, Manfredsson FP, Nejtek VA, Richardson JR, Salvatore MF. Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: A case for diminished GDNF-signaling. Experimental Neurology. 114435. PMID 37178997 DOI: 10.1016/j.expneurol.2023.114435  0.394
2023 Caulfield ME, Vander Werp MJ, Stancati JA, Collier TJ, Sortwell CE, Sandoval IM, Manfredsson FP, Steece-Collier K. Downregulation of striatal Ca1.3 inhibits the escalation of levodopa-induced dyskinesia in male and female parkinsonian rats of advanced age. Neurobiology of Disease. 181: 106111. PMID 37001610 DOI: 10.1016/j.nbd.2023.106111  0.301
2023 Kasanga EA, Han Y, Navarrete W, McManus R, Shifflet MK, Parry C, Barahona A, Manfredsson FP, Nejtek VA, Richardson JR, Salvatore MF. Differential expression of RET and GDNF family receptor, GFR-α1, between striatum and substantia nigra following nigrostriatal lesion: a case for diminished GDNF-signaling. Biorxiv : the Preprint Server For Biology. PMID 36909534 DOI: 10.1101/2023.03.01.530671  0.373
2023 Lai JI, Porcu A, Romoli B, Keisler M, Manfredsson FP, Powell SB, Dulcis D. Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson's Model. International Journal of Molecular Sciences. 24. PMID 36835612 DOI: 10.3390/ijms24044204  0.351
2023 Caulfield ME, Manfredsson FP, Steece-Collier K. The Role of Striatal Cav1.3 Calcium Channels in Therapeutics for Parkinson's Disease. Handbook of Experimental Pharmacology. PMID 36592226 DOI: 10.1007/164_2022_629  0.313
2021 Sandoval IM, Marmion DJ, Meyers KT, Manfredsson FP. Gene Therapy to Modulate Alpha-Synuclein in Synucleinopathies. Journal of Parkinson's Disease. PMID 34092656 DOI: 10.3233/JPD-212679  0.323
2021 Chatterjee D, Marmion DJ, McBride JL, Manfredsson FP, Butler D, Messer A, Kordower JH. Enhanced CNS transduction from AAV.PHP.eB infusion into the cisterna magna of older adult rats compared to AAV9. Gene Therapy. PMID 33753910 DOI: 10.1038/s41434-021-00244-y  0.304
2020 Sellnow RC, Steece-Collier K, Altwal F, Sandoval IM, Kordower JH, Collier TJ, Sortwell CE, West AR, Manfredsson FP. Striatal Nurr1 Facilitates the Dyskinetic State and Exacerbates Levodopa-Induced Dyskinesia in a Rat Model of Parkinson's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32238479 DOI: 10.1523/Jneurosci.2936-19.2020  0.462
2020 Chu Y, Bartus RT, Manfredsson FP, Olanow CW, Kordower JH. Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson's disease. Brain : a Journal of Neurology. 143: 960-975. PMID 32203581 DOI: 10.1093/Brain/Awaa020  0.347
2020 Yelleswarapu NK, Manfredsson F, Galligan J. 351 ENTERIC NEURONAL AGGGREGATION OF α-SYNUCLEIN DISRUPTS NITRERGIC MEDIATED INHIBITORY NEUROMUSCULAR TRANMISSION Gastroenterology. 158. DOI: 10.1016/S0016-5085(20)30840-4  0.38
2019 Kang SS, Liu X, Ahn EH, Xiang J, Manfredsson FP, Yang X, Luo HR, Liles LC, Weinshenker D, Ye K. Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus. The Journal of Clinical Investigation. PMID 31793911 DOI: 10.1172/Jci130513  0.338
2019 Kasanga EA, Owens CL, Cantu MA, Richard A, Davis RW, McDivitt LM, Blancher B, Pruett BS, Tan C, Gajewski A, Manfredsson FP, Nejtek VA, Salvatore MF. GFR-α1 expression in substantia nigra increases bilaterally following unilateral striatal GDNF in aged rats and attenuates nigral tyrosine hydroxylase loss following 6-OHDA nigrostriatal lesion. Acs Chemical Neuroscience. PMID 31538765 DOI: 10.1021/Acschemneuro.9B00291  0.386
2019 Wang ZH, Xiang J, Liu X, Yu SP, Manfredsson FP, Sandoval IM, Wu S, Wang JZ, Ye K. Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer's Disease. Cell Reports. 28: 655-669.e5. PMID 31315045 DOI: 10.1016/J.Celrep.2019.06.054  0.325
2019 Romoli B, Lozada AF, Sandoval IM, Manfredsson FP, Hnasko TS, Berg DK, Dulcis D. Neonatal Nicotine Exposure Primes Midbrain Neurons to a Dopaminergic Phenotype and Increases Adult Drug Consumption. Biological Psychiatry. PMID 31202491 DOI: 10.1016/J.Biopsych.2019.04.019  0.317
2019 Xiang J, Wang ZH, Ahn EH, Liu X, Yu SP, Manfredsson FP, Sandoval IM, Ju G, Wu S, Ye K. Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies. Proceedings of the National Academy of Sciences of the United States of America. PMID 31004063 DOI: 10.1073/Pnas.1901348116  0.317
2019 Steece-Collier K, Stancati JA, Collier NJ, Sandoval IM, Mercado NM, Sortwell CE, Collier TJ, Manfredsson FP. Genetic silencing of striatal CaV1.3 prevents and ameliorates levodopa dyskinesia. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31002755 DOI: 10.1002/Mds.27695  0.395
2019 Hosaka K, Manfredsson FP, Hoh BL. Localized Intra-Arterial Gene Delivery Using AAV. Methods in Molecular Biology (Clifton, N.J.). 1937: 259-265. PMID 30706402 DOI: 10.1007/978-1-4939-9065-8_16  0.334
2019 Benskey MJ, Sandoval IM, Miller K, Sellnow RL, Gezer A, Kuhn NC, Vashon R, Manfredsson FP. Basic Concepts in Viral Vector-Mediated Gene Therapy. Methods in Molecular Biology (Clifton, N.J.). 1937: 3-26. PMID 30706387 DOI: 10.1007/978-1-4939-9065-8_1  0.319
2019 Sellnow RC, Newman JH, Chambers N, West AR, Steece-Collier K, Sandoval IM, Benskey MJ, Bishop C, Manfredsson FP. Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia. Acta Neuropathologica Communications. 7: 8. PMID 30646956 DOI: 10.1186/S40478-018-0653-7  0.432
2018 Wang ZH, Wu W, Kang SS, Liu X, Wu Z, Peng J, Yu SP, Manfredsson FP, Sandoval IM, Liu X, Wang JZ, Ye K. BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT. Jci Insight. 3. PMID 30135302 DOI: 10.1172/Jci.Insight.99007  0.392
2018 Raghunathan R, Polinski NK, Klein JA, Hogan JD, Shao C, Khatri K, Leon DR, McComb ME, Manfredsson FP, Sortwell CE, Zaia J. Glycomic and Proteomic changes in aging brain nigrostriatal pathway. Molecular & Cellular Proteomics : McP. PMID 29915149 DOI: 10.1074/Mcp.Ra118.000680  0.454
2018 Manfredsson FP, Tansey MG, Golde TE. Challenges in Passive Immunization Strategies to Treat Parkinson Disease. Jama Neurology. PMID 29913004 DOI: 10.1001/Jamaneurol.2018.0346  0.312
2018 Kang SS, Ahn EH, Zhang Z, Liu X, Manfredsson FP, Sandoval IM, Dhakal S, Iuvone PM, Cao X, Ye K. α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease. The Embo Journal. PMID 29769405 DOI: 10.15252/Embj.201798878  0.395
2018 Benskey MJ, Sellnow RC, Sandoval IM, Sortwell CE, Lipton JW, Manfredsson FP. Silencing Alpha Synuclein in Mature Nigral Neurons Results in Rapid Neuroinflammation and Subsequent Toxicity. Frontiers in Molecular Neuroscience. 11: 36. PMID 29497361 DOI: 10.3389/Fnmol.2018.00036  0.458
2018 Manfredsson FP, Luk KC, Benskey MJ, Guezer A, Garcia J, Kuhn NC, Sandoval IM, Patterson JR, O'Mara A, Yonkers R, Kordower JH. Induction of alpha-synuclein pathology in the enteric nervous system of the rat and non-human primate results in gastrointestinal dysmotility and transient CNS pathology. Neurobiology of Disease. PMID 29341898 DOI: 10.1016/J.Nbd.2018.01.008  0.613
2017 Fischer DL, Manfredsson FP, Kemp CJ, Cole-Strauss A, Lipton JW, Duffy MF, Polinski NK, Steece-Collier K, Collier TJ, Gombash SE, Buhlinger DJ, Sortwell CE. Subthalamic Nucleus Deep Brain Stimulation Does Not Modify the Functional Deficits or Axonopathy Induced by Nigrostriatal α-Synuclein Overexpression. Scientific Reports. 7: 16356. PMID 29180681 DOI: 10.1038/S41598-017-16690-X  0.703
2017 Fischer DL, Manfredsson FP, Sortwell CE. Can STN DBS protect both nigral somata and innervation of the striatum? Annals of Neurology. PMID 28985650 DOI: 10.1002/Ana.25064  0.644
2017 Kang SS, Zhang Z, Liu X, Manfredsson FP, Benskey MJ, Cao X, Xu J, Sun YE, Ye K. TrkB neurotrophic activities are blocked by α-synuclein, triggering dopaminergic cell death in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28923922 DOI: 10.1073/Pnas.1713969114  0.449
2017 Kanaan NM, Sellnow RC, Boye SL, Coberly B, Bennett A, Agbandje-McKenna M, Sortwell CE, Hauswirth WW, Boye SE, Manfredsson FP. Rationally Engineered AAV Capsids Improve Transduction and Volumetric Spread in the CNS. Molecular Therapy. Nucleic Acids. 8: 184-197. PMID 28918020 DOI: 10.1016/J.Omtn.2017.06.011  0.42
2017 Zhang Z, Kang SS, Liu X, Ahn EH, Zhang Z, He L, Iuvone PM, Duong DM, Seyfried NT, Benskey MJ, Manfredsson FP, Jin L, Sun YE, Wang JZ, Ye K. Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease. Nature Structural & Molecular Biology. PMID 28671665 DOI: 10.1038/Nsmb.3433  0.439
2017 Kang SS, Zhang Z, Liu X, Manfredsson FP, He L, Iuvone PM, Cao X, Sun YE, Jin L, Ye K. α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28096359 DOI: 10.1073/Pnas.1618627114  0.362
2016 Polinski NK, Manfredsson FP, Benskey MJ, Fischer DL, Kemp CJ, Steece-Collier K, Sandoval IM, Paumier KL, Sortwell CE. Impact of age and vector construct on striatal and nigral transgene expression. Molecular Therapy. Methods & Clinical Development. 3: 16082. PMID 27933309 DOI: 10.1038/Mtm.2016.82  0.687
2016 Benskey MJ, Sandoval IM, Manfredsson FP. Continuous Collection of Adeno-Associated Virus from Producer Cell Medium Significantly Increases Total Viral Yield. Human Gene Therapy Methods. 27: 32-45. PMID 26863210 DOI: 10.1089/Hgtb.2015.117  0.308
2016 Collier TJ, Redmond DE, Steece-Collier K, Lipton JW, Manfredsson FP. Is Alpha-Synuclein Loss-of-Function a Contributor to Parkinsonian Pathology? Evidence from Non-human Primates. Frontiers in Neuroscience. 10: 12. PMID 26858591 DOI: 10.3389/Fnins.2016.00012  0.455
2016 Benskey MJ, Perez RG, Manfredsson FP. The contribution of alpha synuclein to neuronal survival and function - Implications for Parkinson's disease. Journal of Neurochemistry. 137: 331-59. PMID 26852372 DOI: 10.1111/Jnc.13570  0.408
2016 Fischer DL, Gombash SE, Kemp CJ, Manfredsson FP, Polinski NK, Duffy MF, Sortwell CE. Viral Vector-Based Modeling of Neurodegenerative Disorders: Parkinson's Disease. Methods in Molecular Biology (Clifton, N.J.). 1382: 367-82. PMID 26611600 DOI: 10.1007/978-1-4939-3271-9_26  0.674
2016 Benskey MJ, Manfredsson FP. Gene Therapy of the Peripheral Nervous System: The Enteric Nervous System. Methods in Molecular Biology (Clifton, N.J.). 1382: 263-74. PMID 26611593 DOI: 10.1007/978-1-4939-3271-9_19  0.363
2016 Benskey MJ, Manfredsson FP. Intraparenchymal Stereotaxic Delivery of rAAV and Special Considerations in Vector Handling. Methods in Molecular Biology (Clifton, N.J.). 1382: 199-215. PMID 26611588 DOI: 10.1007/978-1-4939-3271-9_14  0.327
2016 Benskey MJ, Manfredsson FP. Lentivirus Production and Purification. Methods in Molecular Biology (Clifton, N.J.). 1382: 107-14. PMID 26611582 DOI: 10.1007/978-1-4939-3271-9_8  0.312
2016 Manfredsson FP. Introduction to Viral Vectors and Other Delivery Methods for Gene Therapy of the Nervous System. Methods in Molecular Biology (Clifton, N.J.). 1382: 3-18. PMID 26611575 DOI: 10.1007/978-1-4939-3271-9_1  0.318
2015 Fischer DL, Collier TJ, Cole-Strauss A, Wohlgenant SL, Lipton JW, Steece-Collier K, Manfredsson FP, Kemp CJ, Sortwell CE. High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine. Plos One. 10: e0133957. PMID 26222442 DOI: 10.1371/Journal.Pone.0133957  0.695
2015 Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, Sandoval IM, Fleming S, Dirr E, Polinski NK, Trojanowski JQ, et al. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiology of Disease. 82: 185-199. PMID 26093169 DOI: 10.1016/J.Nbd.2015.06.003  0.446
2015 Kanaan NM, Collier TJ, Cole-Strauss A, Grabinski T, Mattingly ZR, Winn ME, Steece-Collier K, Sortwell CE, Manfredsson FP, Lipton JW. The longitudinal transcriptomic response of the substantia nigra to intrastriatal 6-hydroxydopamine reveals significant upregulation of regeneration-associated genes. Plos One. 10: e0127768. PMID 25992874 DOI: 10.1371/Journal.Pone.0127768  0.381
2015 Grabinski TM, Kneynsberg A, Manfredsson FP, Kanaan NM. A method for combining RNAscope in situ hybridization with immunohistochemistry in thick free-floating brain sections and primary neuronal cultures. Plos One. 10: e0120120. PMID 25794171 DOI: 10.1371/Journal.Pone.0120120  0.325
2015 Benskey MJ, Kuhn NC, Galligan JJ, Garcia J, Boye SE, Hauswirth WW, Mueller C, Boye SL, Manfredsson FP. Targeted gene delivery to the enteric nervous system using AAV: a comparison across serotypes and capsid mutants. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 488-500. PMID 25592336 DOI: 10.1038/Mt.2015.7  0.595
2015 Polinski NK, Gombash SE, Manfredsson FP, Lipton JW, Kemp CJ, Cole-Strauss A, Kanaan NM, Steece-Collier K, Kuhn NC, Wohlgenant SL, Sortwell CE. Recombinant adenoassociated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain. Neurobiology of Aging. 36: 1110-20. PMID 25457558 DOI: 10.1016/J.Neurobiolaging.2014.07.047  0.421
2015 Benskey MJ, Manfredsson FP, Lookingland KJ, Goudreau JL. The role of parkin in the differential susceptibility of tuberoinfundibular and nigrostriatal dopamine neurons to acute toxicant exposure. Neurotoxicology. 46: 1-11. PMID 25447324 DOI: 10.1016/J.Neuro.2014.11.004  0.415
2015 Polinski NK, Congdon L, Luke Fischer D, Manfredsson FP, Benskey M, Kemp C, Kuhn NC, Cole-Strauss A, Steece-Collier K, Paumier KL, Lipton JW, Sortwell CE. 715. Impact of Aging on Recombinant Adeno-Associated and Lentiviral Vector Transduction Efficiency in the Rat Nigrostriatal and Striatonigral Systems Molecular Therapy. 23: S285. DOI: 10.1016/S1525-0016(16)34324-6  0.461
2015 Sellnow RC, Steece-Collier K, Kanaan NM, Sortwell CE, Collier TJ, Cole-Strauss A, Lipton JW, Manfredsson FP. 709. rAAV-Mediated Regulation of Striatal Nurr1 Expression Alters Development and Severity of Levodopa-Induced Dyskinesias in the 6-OHDA Rat Model of Parkinson's Disease Molecular Therapy. 23: S282-S283. DOI: 10.1016/S1525-0016(16)34318-0  0.442
2015 Manfredsson FP, Redmond DE, Lipton JW, Malpass RM, Collier TJ. 386. rAAV-Mediated Reduction of Alpha-Synuclein in the Substantia Nigra of the African Green Monkey Results in Neurodegeneration Molecular Therapy. 23: S153-S154. DOI: 10.1016/S1525-0016(16)33995-8  0.495
2015 Polinski N, Gombash S, Kemp C, Kuhn N, Cole-Strauss A, Wohlgenant S, Kanaan N, Steece-Collier K, Lipton J, Manfredsson F, Sortwell C. Decreased viral vector transducibility in the aged rat midbrain Experimental Gerontology. 68: 102. DOI: 10.1016/J.Exger.2015.01.032  0.353
2014 Gombash SE, Manfredsson FP, Mandel RJ, Collier TJ, Fischer DL, Kemp CJ, Kuhn NM, Wohlgenant SL, Fleming SM, Sortwell CE. Neuroprotective potential of pleiotrophin overexpression in the striatonigral pathway compared with overexpression in both the striatonigral and nigrostriatal pathways. Gene Therapy. 21: 682-93. PMID 24807806 DOI: 10.1038/Gt.2014.42  0.696
2013 Gombash SE, Manfredsson FP, Kemp CJ, Kuhn NC, Fleming SM, Egan AE, Grant LM, Ciucci MR, MacKeigan JP, Sortwell CE. Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system. Plos One. 8: e81426. PMID 24312298 DOI: 10.1371/Journal.Pone.0081426  0.461
2012 Kanaan NM, Manfredsson FP. Loss of functional alpha-synuclein: a toxic event in Parkinson's disease? Journal of Parkinson's Disease. 2: 249-67. PMID 23938255 DOI: 10.3233/Jpd-012138  0.445
2012 Manfredsson FP, Bloom DC, Mandel RJ. Regulated protein expression for in vivo gene therapy for neurological disorders: progress, strategies, and issues. Neurobiology of Disease. 48: 212-21. PMID 22426391 DOI: 10.1016/J.Nbd.2012.03.001  0.371
2012 Gombash SE, Lipton JW, Collier TJ, Madhavan L, Steece-Collier K, Cole-Strauss A, Terpstra BT, Spieles-Engemann AL, Daley BF, Wohlgenant SL, Thompson VB, Manfredsson FP, Mandel RJ, Sortwell CE. Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 544-54. PMID 22008908 DOI: 10.1038/Mt.2011.216  0.496
2011 Manfredsson FP, Mandel RJ. The development of flexible lentiviral vectors for gene transfer in the CNS. Experimental Neurology. 229: 201-6. PMID 21459087 DOI: 10.1016/J.Expneurol.2011.03.013  0.386
2010 Gorbatyuk OS, Li S, Nash K, Gorbatyuk M, Lewin AS, Sullivan LF, Mandel RJ, Chen W, Meyers C, Manfredsson FP, Muzyczka N. In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1450-1457. PMID 28178505 DOI: 10.1038/mt.2010.115  0.333
2010 Gorbatyuk OS, Li S, Nguyen FN, Manfredsson FP, Kondrikova G, Sullivan LF, Meyers C, Chen W, Mandel RJ, Muzyczka N. α-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1758-68. PMID 20664530 DOI: 10.1038/Mt.2010.137  0.417
2010 Gorbatyuk OS, Li S, Nash K, Gorbatyuk M, Lewin AS, Sullivan LF, Mandel RJ, Chen W, Meyers C, Manfredsson FP, Muzyczka N. In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1450-7. PMID 20551914 DOI: 10.1038/Mt.2010.115  0.354
2009 Manfredsson FP, Okun MS, Mandel RJ. Gene therapy for neurological disorders: challenges and future prospects for the use of growth factors for the treatment of Parkinson's disease. Current Gene Therapy. 9: 375-88. PMID 19860652 DOI: 10.2174/156652309789753400  0.447
2009 Manfredsson FP, Burger C, Rising AC, Zuobi-Hasona K, Sullivan LF, Lewin AS, Huang J, Piercefield E, Muzyczka N, Mandel RJ. Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1857-67. PMID 19707186 DOI: 10.1038/Mt.2009.196  0.451
2009 Manfredsson FP, Tumer N, Erdos B, Landa T, Broxson CS, Sullivan LF, Rising AC, Foust KD, Zhang Y, Muzyczka N, Gorbatyuk OS, Scarpace PJ, Mandel RJ. Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 980-91. PMID 19277011 DOI: 10.1038/Mt.2009.45  0.394
2009 Manfredsson FP, Rising AC, Mandel RJ. AAV9: a potential blood-brain barrier buster. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 403-5. PMID 19247366 DOI: 10.1038/Mt.2009.15  0.309
2009 Peden CS, Manfredsson FP, Reimsnider SK, Poirier AE, Burger C, Muzyczka N, Mandel RJ. Striatal readministration of rAAV vectors reveals an immune response against AAV2 capsids that can be circumvented. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 524-37. PMID 19142181 DOI: 10.1038/Mt.2008.284  0.366
2008 Gorbatyuk OS, Li S, Sullivan LF, Chen W, Kondrikova G, Manfredsson FP, Mandel RJ, Muzyczka N. The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 763-8. PMID 18178617 DOI: 10.1073/Pnas.0711053105  0.421
2007 Manfredsson FP, Burger C, Sullivan LF, Muzyczka N, Lewin AS, Mandel RJ. rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease. Experimental Neurology. 207: 289-301. PMID 17678648 DOI: 10.1016/J.Expneurol.2007.06.019  0.452
2007 Reimsnider S, Manfredsson FP, Muzyczka N, Mandel RJ. Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1504-11. PMID 17565350 DOI: 10.1038/Sj.Mt.6300227  0.423
2006 Mandel RJ, Manfredsson FP, Foust KD, Rising A, Reimsnider S, Nash K, Burger C. Recombinant adeno-associated viral vectors as therapeutic agents to treat neurological disorders. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 463-83. PMID 16412695 DOI: 10.1016/J.Ymthe.2005.11.009  0.341
2006 Manfredsson FP, Lewin AS, Mandel RJ. RNA knockdown as a potential therapeutic strategy in Parkinson's disease. Gene Therapy. 13: 517-24. PMID 16267570 DOI: 10.1038/Sj.Gt.3302669  0.378
2006 Reimsnider SK, Manfredsson FP, Burger C, Muzczyka N, Mandel RJ. 903. Re-Administration of Recombinant AAV2 and AAV5 in the Brain Molecular Therapy. 13: S348. DOI: 10.1016/J.Ymthe.2006.08.992  0.352
2006 Manfredsson FP, Rising AC, Mandel RJ. 895. Separate rAAV1 Vectors Co-Infect Striatal Neurons Efficiently Molecular Therapy. 13: S345. DOI: 10.1016/J.Ymthe.2006.08.984  0.407
2006 Manfredsson FP, Mandel RJ, Zolotukhin S, Lewin AS. 1032. rAAV Mediated Knock-Down of Tyrosine Hydroxylase in the Substantia Nigra Using a pol II Transcribed siRNA Molecular Therapy. 13: S396. DOI: 10.1016/J.Ymthe.2006.08.1127  0.369
2005 Reimsnider SK, Manfredsson F, Muzyczka N, Mandel RJ. 1082. Transduction Comparison of AAV Serotype Vectors in the Central Nervous System Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.629  0.372
2005 Manfredsson FP, Lewin AS, Muzyczka N, Burger C, Mandel RJ. 59. rAAV-Mediated Nigral Parkin Over-Expression Is Neuroprotective in the 6-OHDA Rat Model of Parkinson's Disease Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.087  0.505
2004 Manfredsson FP, Lewin AS, Mandel RJ. 529. rAAV mediated parkin expression confers some protection in the rat 6-OHDA lesion model Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.476  0.454
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